TW429243B - Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them - Google Patents

Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them

Info

Publication number
TW429243B
TW429243B TW086107502A TW86107502A TW429243B TW 429243 B TW429243 B TW 429243B TW 086107502 A TW086107502 A TW 086107502A TW 86107502 A TW86107502 A TW 86107502A TW 429243 B TW429243 B TW 429243B
Authority
TW
Taiwan
Prior art keywords
medicament
hydrogen
ortho
methoxy
halogen
Prior art date
Application number
TW086107502A
Other languages
English (en)
Chinese (zh)
Inventor
Andreas Weichert
Joachim Brendel
Heinz-Werner Kleemann
Hans Jochen Lang
Jan-Robert Schwark
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of TW429243B publication Critical patent/TW429243B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
TW086107502A 1996-06-04 1997-06-02 Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them TW429243B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19622370A DE19622370A1 (de) 1996-06-04 1996-06-04 Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (1)

Publication Number Publication Date
TW429243B true TW429243B (en) 2001-04-11

Family

ID=7796095

Family Applications (1)

Application Number Title Priority Date Filing Date
TW086107502A TW429243B (en) 1996-06-04 1997-06-02 Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them

Country Status (29)

Country Link
US (1) US6011063A (enExample)
EP (1) EP0811610B1 (enExample)
JP (1) JP4101904B2 (enExample)
KR (1) KR980002019A (enExample)
CN (1) CN1064956C (enExample)
AR (1) AR008761A1 (enExample)
AT (1) ATE209630T1 (enExample)
AU (1) AU723665B2 (enExample)
BR (1) BR9703440A (enExample)
CA (1) CA2206758C (enExample)
CZ (1) CZ289411B6 (enExample)
DE (2) DE19622370A1 (enExample)
DK (1) DK0811610T3 (enExample)
ES (1) ES2166487T3 (enExample)
HR (1) HRP970304B1 (enExample)
HU (1) HUP9700989A3 (enExample)
ID (1) ID17038A (enExample)
IL (1) IL120988A0 (enExample)
MX (1) MX9704094A (enExample)
NO (1) NO310188B1 (enExample)
NZ (1) NZ314973A (enExample)
PL (1) PL185757B1 (enExample)
PT (1) PT811610E (enExample)
RU (1) RU2214397C2 (enExample)
SI (1) SI0811610T1 (enExample)
SK (1) SK282628B6 (enExample)
TR (1) TR199700453A2 (enExample)
TW (1) TW429243B (enExample)
ZA (1) ZA974869B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410563B1 (en) 1999-12-22 2002-06-25 Merck Frosst Canada & Co. Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
MY123585A (en) 2000-03-23 2006-05-31 Merck Canada Inc Tri-aryl-substituted-ethane pde4 inhibitors.
US6639077B2 (en) 2000-03-23 2003-10-28 Merck Frosst Canada & Co. Tri-aryl-substituted-ethane PDE4 inhibitors
AU6196201A (en) 2000-05-25 2001-12-03 Merck Frosst Canada Inc Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor
US6740666B2 (en) 2000-12-20 2004-05-25 Merck & Co., Inc. Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
ATE303384T1 (de) 2001-05-24 2005-09-15 Merck Frosst Canada Inc 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
JO2311B1 (en) 2001-08-29 2005-09-12 ميرك فروست كندا ليمتد Alkyl inhibitors Ariel phosphodiesterase-4
EP1485093B1 (en) 2002-03-12 2010-11-03 Merck Sharp & Dohme Corp. Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5
GB0916163D0 (en) * 2009-09-15 2009-10-28 Shire Llc Prodrugs of guanfacine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ284456B6 (cs) * 1992-02-15 1998-12-16 Hoechst Aktiengesellschaft Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
DE59403818D1 (de) * 1993-02-20 1997-10-02 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, als Inhibitoren des zellulären Na+/H+-Austauschs oder als Diagnostikum sowie sie enthaltendes Medikament
DE4318756A1 (de) * 1993-06-05 1994-12-08 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4327244A1 (de) * 1993-08-13 1995-02-16 Hoechst Ag Harnstoffsubstituierte Benzoylguandine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4328869A1 (de) * 1993-08-27 1995-03-02 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4422685A1 (de) * 1994-06-29 1996-01-04 Hoechst Ag Ortho-amino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
ATE209630T1 (de) 2001-12-15
CN1064956C (zh) 2001-04-25
NO972527L (no) 1997-12-05
DE19622370A1 (de) 1997-12-11
NO310188B1 (no) 2001-06-05
US6011063A (en) 2000-01-04
KR980002019A (ko) 1998-03-30
HUP9700989A2 (en) 1997-12-29
DK0811610T3 (da) 2002-03-25
NO972527D0 (no) 1997-06-03
JP4101904B2 (ja) 2008-06-18
MX9704094A (es) 1997-12-31
CZ289411B6 (cs) 2002-01-16
HRP970304B1 (en) 2002-10-31
HU9700989D0 (en) 1997-07-28
TR199700453A2 (xx) 1997-12-21
DE59705495D1 (de) 2002-01-10
NZ314973A (en) 1998-09-24
IL120988A0 (en) 1997-11-20
ID17038A (id) 1997-12-04
RU2214397C2 (ru) 2003-10-20
AU723665B2 (en) 2000-08-31
AU2465097A (en) 1997-12-11
SI0811610T1 (en) 2002-04-30
PL185757B1 (pl) 2003-07-31
HRP970304A2 (en) 1998-04-30
BR9703440A (pt) 1998-09-29
JPH1067731A (ja) 1998-03-10
SK282628B6 (sk) 2002-10-08
AR008761A1 (es) 2000-02-23
CZ169697A3 (en) 1997-12-17
ZA974869B (en) 1997-12-04
EP0811610B1 (de) 2001-11-28
EP0811610A1 (de) 1997-12-10
SK69697A3 (en) 1998-01-14
CA2206758A1 (en) 1997-12-04
PT811610E (pt) 2002-05-31
ES2166487T3 (es) 2002-04-16
CA2206758C (en) 2007-08-14
CN1175572A (zh) 1998-03-11
PL320327A1 (en) 1997-12-08
HUP9700989A3 (en) 1998-04-28

Similar Documents

Publication Publication Date Title
MX9300784A (es) Benzoilguanidinas aminosustituidas, procedimiento para su preparacion, su empleo como medicamento, asi como medicamento que las contiene.
CA2089440A1 (en) Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicaments containing them
TW429245B (en) Substituted benzenesulfonylureas and -thioureas- processes for their preparation and their use as pharmaceuticals
AU672246B2 (en) Substituted benzoylguanidines, process for their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them
CA2258217A1 (en) Substituted cyclopentane compounds useful as neuraminidase inhibitors
CA2206366A1 (en) Substituted 2-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
ES2109545T3 (es) Benzoilguanidina sustituida, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico asi como el medicamento que la contiene.
CA2179015A1 (en) Use of bis(amidinobenzimidazoles) in the manufacture of medicament for inhibiting retroviral integrase
MX9704094A (es) Benzoil-guanidinas sustituidas en orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.
CA2206362A1 (en) Substituted 1-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
CA2093202A1 (en) Sterilant gas mixture
IL117927A0 (en) Antiarrhythmic and cardioprotective substituted indenoylguanidines
MY117500A (en) Ortho- substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them
MY117642A (en) Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
MY116861A (en) Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them
CA2157856A1 (en) Fluoroalkyl/alkenyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
MY129959A (en) Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them
MY117304A (en) Ortho-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic, agent and a medicament comprising them.
TW430642B (en) Substituted diaryldicarboxylic acid diguanidides, processes for their preparation, their use as a medicament or diagnostic, and medicament containing them
TW353657B (en) Substituted benzenedicarboxylic acid diguanides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
AR005812A1 (es) Guanididas de acidos tiofenilalquenilcarboxilicos sustituidas, su empleo para la preparacion de medicamento o agente diagnostico, asi como medicamento que las contiene
SE9902268D0 (sv) Pharmaceutically active compounds
CA2292017A1 (en) Substituted cycloheptenes, their preparation and use
MY140691A (en) Pentafluorosulfanylphenyl-substituted benzoylguanidines, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
SE9902270D0 (sv) Pharmaceutically active compounds

Legal Events

Date Code Title Description
GD4A Issue of patent certificate for granted invention patent