MX9701619A - Benzoilguanidinas sustituidas en posicion orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene. - Google Patents

Benzoilguanidinas sustituidas en posicion orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.

Info

Publication number
MX9701619A
MX9701619A MX9701619A MX9701619A MX9701619A MX 9701619 A MX9701619 A MX 9701619A MX 9701619 A MX9701619 A MX 9701619A MX 9701619 A MX9701619 A MX 9701619A MX 9701619 A MX9701619 A MX 9701619A
Authority
MX
Mexico
Prior art keywords
medicament
benzoylguanidines
substituted
well
ortho position
Prior art date
Application number
MX9701619A
Other languages
English (en)
Other versions
MXPA97001619A (es
Inventor
Udo Albus
Joachim Brendel
Heinz-Werner Kleemann
Hans Jochen Lang
Wolfgang Scholz
Jan-Robert Schwark
Andreas Weichert
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of MXPA97001619A publication Critical patent/MXPA97001619A/es
Publication of MX9701619A publication Critical patent/MX9701619A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Las benzoilguanidinas sustituidas en posicion orto de la formula I: en la que R(1) hasta R(4) tienen los significados indicados en las reivindicaciones, son apropiados como medicamentos antiarrítmicos con una componente cardioprotectora para la profilaxis del infarto y el tratamiento del infarto así como para el tratamiento de la angina de pecho. Inhiben también a título preventivo los procesos patofisiologicos al resultar lesiones inducidas isquémicamente, especialmente en el caso de la provocacion de arritmias cardíacas inducidas isquémicamente.
MX9701619A 1996-03-04 1997-03-03 Benzoilguanidinas sustituidas en posicion orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene. MX9701619A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19608161.1 1996-03-04
DE19608161A DE19608161A1 (de) 1996-03-04 1996-03-04 Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (2)

Publication Number Publication Date
MXPA97001619A MXPA97001619A (es) 1998-04-01
MX9701619A true MX9701619A (es) 1998-04-30

Family

ID=7787087

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9701619A MX9701619A (es) 1996-03-04 1997-03-03 Benzoilguanidinas sustituidas en posicion orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.

Country Status (30)

Country Link
US (1) US6262123B1 (es)
EP (1) EP0794172B1 (es)
JP (1) JP4039586B2 (es)
KR (1) KR970065511A (es)
CN (1) CN1071318C (es)
AR (1) AR006051A1 (es)
AT (1) ATE207462T1 (es)
AU (1) AU707619B2 (es)
BR (1) BR9701159A (es)
CA (1) CA2198980A1 (es)
CZ (1) CZ293144B6 (es)
DE (2) DE19608161A1 (es)
DK (1) DK0794172T3 (es)
ES (1) ES2166481T3 (es)
HR (1) HRP970125B1 (es)
HU (1) HUP9700542A3 (es)
ID (1) ID16106A (es)
IL (1) IL120358A (es)
MX (1) MX9701619A (es)
MY (1) MY116861A (es)
NO (1) NO308793B1 (es)
NZ (1) NZ314325A (es)
PL (1) PL185751B1 (es)
PT (1) PT794172E (es)
RU (1) RU2212400C2 (es)
SI (1) SI0794172T1 (es)
SK (1) SK283934B6 (es)
TR (1) TR199700131A2 (es)
TW (1) TW440558B (es)
ZA (1) ZA971815B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10001879A1 (de) 2000-01-19 2001-07-19 Aventis Pharma Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
CN100371328C (zh) * 2006-01-19 2008-02-27 中国药科大学 取代苯甲酰基胍衍生物、其制备方法及其医药用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW250477B (es) 1992-12-15 1995-07-01 Hoechst Ag
EP0612723B1 (de) 1993-02-20 1997-08-27 Hoechst Aktiengesellschaft Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, als Inhibitoren des zellulären Na+/H+-Austauschs oder als Diagnostikum sowie sie enthaltendes Medikament
DE4318756A1 (de) 1993-06-05 1994-12-08 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4328869A1 (de) * 1993-08-27 1995-03-02 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4404183A1 (de) * 1994-02-10 1995-08-17 Merck Patent Gmbh 4-Amino-1-piperidylbenzoylguanidine
DE4417004A1 (de) 1994-05-13 1995-11-16 Hoechst Ag Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4421495A1 (de) * 1994-06-20 1995-12-21 Merck Patent Gmbh Heterocyclyloxy-benzoylguanidine
DE4430213A1 (de) * 1994-08-28 1996-02-29 Merck Patent Gmbh Arylbenzoylguanidine
DE4430861A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Heterocyclyl-benzoylguanidine
DE19517848A1 (de) * 1995-05-16 1996-11-21 Merck Patent Gmbh Fluorhaltige Benzoylguanidine
DE19531138A1 (de) * 1995-08-24 1997-02-27 Merck Patent Gmbh Alkenyl-benzoylguanidin-Derivate
DE19624178A1 (de) * 1996-06-18 1998-01-08 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
HUP9700542A1 (en) 1997-12-29
ATE207462T1 (de) 2001-11-15
HUP9700542A3 (en) 1998-01-28
RU2212400C2 (ru) 2003-09-20
DE59705019D1 (de) 2001-11-29
CN1160042A (zh) 1997-09-24
SK27697A3 (en) 1997-11-05
KR970065511A (ko) 1997-10-13
HRP970125B1 (en) 2002-06-30
TR199700131A2 (tr) 1997-09-21
EP0794172A1 (de) 1997-09-10
IL120358A0 (en) 1997-07-13
ES2166481T3 (es) 2002-04-16
NZ314325A (en) 1998-02-26
CN1071318C (zh) 2001-09-19
PL185751B1 (pl) 2003-07-31
PL318415A1 (en) 1997-09-15
CZ293144B6 (cs) 2004-02-18
NO970963L (no) 1997-09-05
TW440558B (en) 2001-06-16
ZA971815B (en) 1997-09-04
AU707619B2 (en) 1999-07-15
HU9700542D0 (en) 1997-04-28
IL120358A (en) 2002-04-21
ID16106A (id) 1997-09-04
JP4039586B2 (ja) 2008-01-30
EP0794172B1 (de) 2001-10-24
DE19608161A1 (de) 1997-09-11
HRP970125A2 (en) 1998-04-30
BR9701159A (pt) 1998-12-15
MY116861A (en) 2004-04-30
NO308793B1 (no) 2000-10-30
CZ65497A3 (cs) 1998-05-13
SK283934B6 (sk) 2004-05-04
CA2198980A1 (en) 1997-09-04
DK0794172T3 (da) 2002-02-11
AR006051A1 (es) 1999-07-21
NO970963D0 (no) 1997-03-03
AU1499797A (en) 1997-09-11
US6262123B1 (en) 2001-07-17
PT794172E (pt) 2002-02-28
SI0794172T1 (en) 2002-10-31
JPH107644A (ja) 1998-01-13

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees