MX9701618A - Benzoilguanidinas sustituidas en posicion orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene. - Google Patents

Benzoilguanidinas sustituidas en posicion orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.

Info

Publication number
MX9701618A
MX9701618A MX9701618A MX9701618A MX9701618A MX 9701618 A MX9701618 A MX 9701618A MX 9701618 A MX9701618 A MX 9701618A MX 9701618 A MX9701618 A MX 9701618A MX 9701618 A MX9701618 A MX 9701618A
Authority
MX
Mexico
Prior art keywords
medicament
substituted
well
benzoylguanidines
ortho position
Prior art date
Application number
MX9701618A
Other languages
English (en)
Other versions
MXPA97001618A (es
Inventor
Udo Albus
Joachim Brendel
Heinz-Werner Kleemann
Hans Jochen Lang
Wolfgang Scholz
Jan-Robert Schwark
Andreas Weichert
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of MX9701618A publication Critical patent/MX9701618A/es
Publication of MXPA97001618A publication Critical patent/MXPA97001618A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Benzoilguanidinas sustituidas en posicion orto de la formula I: en la que R(1) hasta R(4) tienen los significados indicados en las reivindicaciones, son apropiadas como medicamentos antiarrítmicos con una componente cardioprotectora para la profilaxis del infarto y el tratamiento del infarto, así como para el tratamiento de la angina de pecho. Estas inhiben también preventivamente los procesos patofisiologicos al formarse lesiones inducidas isquémicamente, especialmente en el caso de la provocacion de arritmias cardíacas inducidas isquémicamente.
MXPA/A/1997/001618A 1996-03-04 1997-03-03 Benzoilguanidinas sustituidas en posicion orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene MXPA97001618A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19608162A DE19608162A1 (de) 1996-03-04 1996-03-04 Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19608162.9 1996-03-04

Publications (2)

Publication Number Publication Date
MX9701618A true MX9701618A (es) 1997-09-30
MXPA97001618A MXPA97001618A (es) 1998-07-03

Family

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Also Published As

Publication number Publication date
SK27597A3 (en) 1997-11-05
NO970964D0 (no) 1997-03-03
CZ65397A3 (cs) 1998-05-13
BR9701160A (pt) 1998-12-15
HU9700543D0 (en) 1997-04-28
HUP9700543A3 (en) 2000-03-28
TR199700128A2 (tr) 1997-09-21
PL318416A1 (en) 1997-09-15
US6153651A (en) 2000-11-28
IL120359A0 (en) 1997-07-13
MY129959A (en) 2007-05-31
JPH09328462A (ja) 1997-12-22
EP0794171A2 (de) 1997-09-10
DE19608162A1 (de) 1997-09-11
TW386989B (en) 2000-04-11
AR006052A1 (es) 1999-07-21
AU707403B2 (en) 1999-07-08
CA2198979A1 (en) 1997-09-04
AU1499897A (en) 1997-09-11
HUP9700543A2 (en) 1997-12-29
NZ314326A (en) 1997-11-24
CN1160041A (zh) 1997-09-24
EP0794171A3 (de) 1998-08-19
KR970065512A (ko) 1997-10-13
ZA971814B (en) 1997-09-04
HRP970126A2 (en) 1998-04-30
NO970964L (no) 1997-09-05

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal