NO943210L - Laktolderivater, deres fremstilling og anvendelse - Google Patents

Laktolderivater, deres fremstilling og anvendelse

Info

Publication number
NO943210L
NO943210L NO943210A NO943210A NO943210L NO 943210 L NO943210 L NO 943210L NO 943210 A NO943210 A NO 943210A NO 943210 A NO943210 A NO 943210A NO 943210 L NO943210 L NO 943210L
Authority
NO
Norway
Prior art keywords
group
substituted
acyl group
esterified
chem
Prior art date
Application number
NO943210A
Other languages
English (en)
Other versions
NO943210D0 (no
Inventor
Takashi Sohda
Yukio Fujisawa
Satoru Oi
Junji Mizoguchi
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of NO943210D0 publication Critical patent/NO943210D0/no
Publication of NO943210L publication Critical patent/NO943210L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Det blir beskrevet en ny forbindelse med formel (la) eller (I): A¿O R3¿o¿NH-CH-CH-0-B (la) hvor O er en eller to aminosyrerester som kan være substituert; R3 er en karboksylgruppe som kan være esterifisert eller en acylgruppe; A er en alkylen- gruppe; B er hydrogen eller en alkylgruppe som kan være substituert eller acylgruppe: eller et salt av dette; R2 Ri A¿O l l II R3---(NH-CH-CO)m---(NH-CH-CO)n---NH-CH-CH-0-B hvor R1 og R2 hver er like eller forskjellige og hver er hydrogen eller en hydrokarbonrest som kan være substituert; R3, A og B har samme definisjonen som vist ovenfor; m og n er hver lik O eller 1; forutsatt at når både m og n er lik O, står R3 for en karboksylgruppe som kan være esterifisert eller en acylgruppe som ikke har færre enn 7 karbonatomer; eller et salt av dette. Forbindelsene (la) eller (I) viser cathepsin L hemmende og beresorpsjonshemmende aktivitet og er nyttig som profylaktisk/terapeutisk middel for osteoporose.
NO943210A 1993-09-03 1994-08-30 Laktolderivater, deres fremstilling og anvendelse NO943210L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP21965593 1993-09-03
JP16850194 1994-07-20
JP19038594 1994-08-12

Publications (2)

Publication Number Publication Date
NO943210D0 NO943210D0 (no) 1994-08-30
NO943210L true NO943210L (no) 1995-03-06

Family

ID=27323012

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943210A NO943210L (no) 1993-09-03 1994-08-30 Laktolderivater, deres fremstilling og anvendelse

Country Status (12)

Country Link
US (1) US5496834A (no)
EP (1) EP0641800B1 (no)
KR (1) KR950008497A (no)
CN (1) CN1106001A (no)
AT (1) ATE212036T1 (no)
AU (1) AU678493B2 (no)
CA (1) CA2131397A1 (no)
DE (1) DE69429642T2 (no)
FI (1) FI944040A (no)
HU (1) HUT68717A (no)
NO (1) NO943210L (no)
NZ (1) NZ264376A (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW394764B (en) * 1995-02-14 2000-06-21 Mitsubishi Chemcal Corp Oxygen-containing heterocyclic derivatives
US20030096760A1 (en) * 1997-03-10 2003-05-22 Smithklinebeecham Corporation Method of antagonizing the human SRC SH2 domain
ATE318809T1 (de) 1999-11-05 2006-03-15 Sod Conseils Rech Applic Heterocyclische verbindungen und ihre verwendung als medikamente
FR2800737B1 (fr) * 1999-11-05 2006-06-30 Sod Conseils Rech Applic Nouveaux composes heterocycliques et leur application a titre de medicaments
US6720327B2 (en) * 2000-09-27 2004-04-13 Pharmacia Corporation Lactone integrin antagonists
DE10124041A1 (de) * 2001-05-16 2002-11-21 Graffinity Pharm Design Gmbh Protease Inhibitoren
EP1489076B1 (en) * 2002-03-15 2008-08-13 Senju Pharmaceutical Co., Ltd. Cyclic hemiacetal derivative and use thereof
WO2005033068A1 (en) * 2003-10-06 2005-04-14 Oy Juvantia Pharma Ltd Somatostatin receptor 1 and/or 4 selective agonists and antagonists
WO2008045017A2 (en) * 2005-06-22 2008-04-17 Diamond Scott L Sars and ebola inhibitors and use thereof, and methods for their discovery
AU2022306289A1 (en) 2021-07-09 2024-01-18 Aligos Therapeutics, Inc. Anti-viral compounds
US12065428B2 (en) 2021-09-17 2024-08-20 Aligos Therapeutics, Inc. Anti-viral compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0504938A3 (en) * 1991-03-22 1993-04-14 Suntory Limited Prophylactic and therapeutic agent for bone diseases comprising di- or tripeptide derivative as active ingredient
DE69226820T2 (de) * 1991-06-21 1999-05-12 Merck & Co., Inc., Rahway, N.J. Peptidylderivate als Inhibitoren von Interleukin-1B-konvertierenden Enzymen

Also Published As

Publication number Publication date
CN1106001A (zh) 1995-08-02
HUT68717A (en) 1995-07-28
AU678493B2 (en) 1997-05-29
CA2131397A1 (en) 1995-03-04
HU9402536D0 (en) 1994-10-28
DE69429642D1 (de) 2002-02-21
NO943210D0 (no) 1994-08-30
NZ264376A (en) 1996-03-26
FI944040A (fi) 1995-03-04
EP0641800B1 (en) 2002-01-16
EP0641800A1 (en) 1995-03-08
KR950008497A (ko) 1995-04-17
AU7168294A (en) 1995-03-16
DE69429642T2 (de) 2002-09-12
ATE212036T1 (de) 2002-02-15
FI944040A0 (fi) 1994-09-02
US5496834A (en) 1996-03-05

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