TW226022B - - Google Patents

Info

Publication number
TW226022B
TW226022B TW080103367A TW80103367A TW226022B TW 226022 B TW226022 B TW 226022B TW 080103367 A TW080103367 A TW 080103367A TW 80103367 A TW80103367 A TW 80103367A TW 226022 B TW226022 B TW 226022B
Authority
TW
Taiwan
Prior art keywords
csf
ser
residue
derivatives
naturally occurring
Prior art date
Application number
TW080103367A
Other languages
English (en)
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909009623A external-priority patent/GB9009623D0/en
Priority claimed from GB909013773A external-priority patent/GB9013773D0/en
Priority claimed from GB909016215A external-priority patent/GB9016215D0/en
Priority claimed from GB919102799A external-priority patent/GB9102799D0/en
Application filed by Ici Plc filed Critical Ici Plc
Application granted granted Critical
Publication of TW226022B publication Critical patent/TW226022B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/68—Stabilisation of the vector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/145—Colony stimulating factor
TW080103367A 1990-04-30 1991-04-30 TW226022B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB909009623A GB9009623D0 (en) 1990-04-30 1990-04-30 Polypeptides
GB909013773A GB9013773D0 (en) 1990-06-20 1990-06-20 Polypeptides
GB909016215A GB9016215D0 (en) 1990-07-24 1990-07-24 Polypeptides
GB919102799A GB9102799D0 (en) 1991-02-11 1991-02-11 Polypeptides
GB919107846A GB9107846D0 (en) 1990-04-30 1991-04-12 Polypeptides

Publications (1)

Publication Number Publication Date
TW226022B true TW226022B (zh) 1994-07-01

Family

ID=27450502

Family Applications (1)

Application Number Title Priority Date Filing Date
TW080103367A TW226022B (zh) 1990-04-30 1991-04-30

Country Status (22)

Country Link
US (1) US5416195A (zh)
EP (1) EP0459630B1 (zh)
JP (1) JPH06100593A (zh)
KR (1) KR910018406A (zh)
AT (1) ATE169336T1 (zh)
AU (1) AU644647B2 (zh)
CA (1) CA2041454A1 (zh)
CS (1) CS125091A3 (zh)
DE (1) DE69129927T2 (zh)
DK (1) DK0459630T3 (zh)
ES (1) ES2118737T3 (zh)
FI (1) FI912086A (zh)
GB (1) GB9107846D0 (zh)
GR (1) GR3027590T3 (zh)
HU (1) HUT60769A (zh)
IE (1) IE911440A1 (zh)
IL (1) IL97993A0 (zh)
NO (1) NO911696L (zh)
NZ (1) NZ237974A (zh)
PT (1) PT97529A (zh)
TW (1) TW226022B (zh)
ZW (1) ZW4891A1 (zh)

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US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
AU7795094A (en) * 1993-09-15 1995-04-03 New York University Dna sequence which binds transcriptional regulatory proteins activated in response to various cytokines and uses thereof
US5536495A (en) * 1994-04-15 1996-07-16 Foster; Preston F. Use of G-CSF to reduce acute rejection
US20030053982A1 (en) 1994-09-26 2003-03-20 Kinstler Olaf B. N-terminally chemically modified protein compositions and methods
US5573911A (en) * 1994-10-03 1996-11-12 Lifecodes Corp. Methods and materials for detecting autoimmune antibodies
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
IT1285405B1 (it) * 1995-06-06 1998-06-03 Alza Corp Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.
KR100440460B1 (ko) * 1998-07-08 2004-10-08 주식회사유한양행 인체 과립구 콜로니 자극인자의 유전자, 재조합 벡터 및 형질 전환체 및 그들을 이용한 인체 과립구 콜로니 자극인자의 제조방법
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US7208473B2 (en) * 1999-01-06 2007-04-24 Xencor, Inc. Nucleic acids and protein variants of hG-CSF with granulopoietic activity
US6627186B1 (en) 1999-01-06 2003-09-30 Xencor Nucleic acids and protein variants of hG-CSF with granulopoietic activity
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JP4444652B2 (ja) * 2001-07-11 2010-03-31 マキシゲン・ホールディングズ・リミテッド Ｇ−ｃｓｆ結合体
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
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DK2279755T3 (da) 2001-10-10 2014-05-26 Ratiopharm Gmbh Remodellering og glycokonjugering af fibroblastvækstfaktor (FGF)
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ATE466085T1 (de) * 2002-09-09 2010-05-15 Hanall Pharmaceutical Co Ltd Protease-resistente modifizierte interferon alpha polypeptide
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Also Published As

Publication number Publication date
HUT60769A (en) 1992-10-28
NO911696D0 (no) 1991-04-29
DE69129927D1 (de) 1998-09-10
ATE169336T1 (de) 1998-08-15
IE911440A1 (en) 1991-11-06
CA2041454A1 (en) 1991-10-31
GB9107846D0 (en) 1991-05-29
FI912086A (fi) 1991-10-31
ES2118737T3 (es) 1998-10-01
HU911440D0 (en) 1991-11-28
JPH06100593A (ja) 1994-04-12
FI912086A0 (fi) 1991-04-30
US5416195A (en) 1995-05-16
EP0459630A3 (en) 1992-10-21
NO911696L (no) 1991-10-31
AU7628491A (en) 1991-11-14
DK0459630T3 (da) 1999-05-03
EP0459630B1 (en) 1998-08-05
GR3027590T3 (en) 1998-11-30
PT97529A (pt) 1992-01-31
AU644647B2 (en) 1993-12-16
CS125091A3 (en) 1992-02-19
EP0459630A2 (en) 1991-12-04
ZW4891A1 (en) 1992-01-01
DE69129927T2 (de) 1999-04-01
NZ237974A (en) 1993-09-27
KR910018406A (ko) 1991-11-30
IL97993A0 (en) 1992-06-21

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