ATE169336T1 - G-csf polypeptide derivatives - Google Patents
G-csf polypeptide derivativesInfo
- Publication number
- ATE169336T1 ATE169336T1 AT91303868T AT91303868T ATE169336T1 AT E169336 T1 ATE169336 T1 AT E169336T1 AT 91303868 T AT91303868 T AT 91303868T AT 91303868 T AT91303868 T AT 91303868T AT E169336 T1 ATE169336 T1 AT E169336T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- csf
- ser
- residue
- naturally occurring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/68—Stabilisation of the vector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/145—Colony stimulating factor
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909009623A GB9009623D0 (en) | 1990-04-30 | 1990-04-30 | Polypeptides |
GB909013773A GB9013773D0 (en) | 1990-06-20 | 1990-06-20 | Polypeptides |
GB909016215A GB9016215D0 (en) | 1990-07-24 | 1990-07-24 | Polypeptides |
GB919102799A GB9102799D0 (en) | 1991-02-11 | 1991-02-11 | Polypeptides |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE169336T1 true ATE169336T1 (de) | 1998-08-15 |
Family
ID=27450502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT91303868T ATE169336T1 (de) | 1990-04-30 | 1991-04-29 | G-csf polypeptide derivatives |
Country Status (23)
Country | Link |
---|---|
US (1) | US5416195A (de) |
EP (1) | EP0459630B1 (de) |
JP (1) | JPH06100593A (de) |
KR (1) | KR910018406A (de) |
AT (1) | ATE169336T1 (de) |
AU (1) | AU644647B2 (de) |
BG (1) | BG94328A (de) |
CA (1) | CA2041454A1 (de) |
CS (1) | CS125091A3 (de) |
DE (1) | DE69129927T2 (de) |
DK (1) | DK0459630T3 (de) |
ES (1) | ES2118737T3 (de) |
FI (1) | FI912086A (de) |
GB (1) | GB9107846D0 (de) |
GR (1) | GR3027590T3 (de) |
HU (1) | HUT60769A (de) |
IE (1) | IE911440A1 (de) |
IL (1) | IL97993A0 (de) |
NO (1) | NO911696L (de) |
NZ (1) | NZ237974A (de) |
PT (1) | PT97529A (de) |
TW (1) | TW226022B (de) |
ZW (1) | ZW4891A1 (de) |
Families Citing this family (83)
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US5718893A (en) * | 1984-04-15 | 1998-02-17 | Foster; Preston F. | Use of G-CSF to reduce acute rejection |
IE912365A1 (en) * | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
US5581476A (en) * | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
WO1995008001A1 (en) * | 1993-09-15 | 1995-03-23 | New York University | Dna sequence which binds transcriptional regulatory proteins activated in response to various cytokines and uses thereof |
US5536495A (en) * | 1994-04-15 | 1996-07-16 | Foster; Preston F. | Use of G-CSF to reduce acute rejection |
US20030053982A1 (en) | 1994-09-26 | 2003-03-20 | Kinstler Olaf B. | N-terminally chemically modified protein compositions and methods |
US5573911A (en) * | 1994-10-03 | 1996-11-12 | Lifecodes Corp. | Methods and materials for detecting autoimmune antibodies |
US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
IT1285405B1 (it) * | 1995-06-06 | 1998-06-03 | Alza Corp | Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto. |
KR100440460B1 (ko) * | 1998-07-08 | 2004-10-08 | 주식회사유한양행 | 인체 과립구 콜로니 자극인자의 유전자, 재조합 벡터 및 형질 전환체 및 그들을 이용한 인체 과립구 콜로니 자극인자의 제조방법 |
US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
US7208473B2 (en) * | 1999-01-06 | 2007-04-24 | Xencor, Inc. | Nucleic acids and protein variants of hG-CSF with granulopoietic activity |
US6627186B1 (en) | 1999-01-06 | 2003-09-30 | Xencor | Nucleic acids and protein variants of hG-CSF with granulopoietic activity |
KR100356140B1 (ko) * | 1999-07-08 | 2002-10-19 | 한미약품공업 주식회사 | 인간 과립구 콜로니 자극인자 변이체 및 이의 생산 방법 |
US6555660B2 (en) * | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
US6646110B2 (en) * | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
US6831158B2 (en) * | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
KR100408429B1 (ko) * | 2000-01-24 | 2003-12-06 | 한미약품 주식회사 | 유즙 중에 인간 과립구 콜로니 자극인자를 생산하는형질전환 흑염소 |
ES2220673T3 (es) | 2000-02-29 | 2004-12-16 | Pfizer Products Inc. | Factor estimulante de colonias de granulocitos estabilizado. |
US8435939B2 (en) | 2000-09-05 | 2013-05-07 | Biokine Therapeutics Ltd. | Polypeptide anti-HIV agent containing the same |
MXPA03002045A (es) * | 2000-09-08 | 2003-07-24 | Amgen Inc | Composiciones analogas de factor estimulador de colonias de granulocitos y metodos para su elaboracion. |
YU17603A (sh) | 2000-09-08 | 2006-05-25 | Gryphon Sciences | Sintetički proteini koji stimulišu eritropoezu |
US7118737B2 (en) | 2000-09-08 | 2006-10-10 | Amylin Pharmaceuticals, Inc. | Polymer-modified synthetic proteins |
ATE400030T1 (de) | 2001-02-19 | 2008-07-15 | Merck Patent Gmbh | Methode zur identifizierung von t-zellepitopen und deren anwendung zur herstellung von molekülen mit reduzierter immunogenität |
EP1425304B9 (de) | 2001-07-11 | 2010-09-08 | Maxygen, Inc. | G-csf konjugate |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
ES2561985T3 (es) | 2001-10-10 | 2016-03-01 | Ratiopharm Gmbh | Remodelación y glicoconjugación de anticuerpos |
ZA200700168B (en) | 2001-10-10 | 2010-02-24 | Novo Nordisk As | Remodeling and glycoconjugation of peptides |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
WO2003078461A1 (en) | 2002-03-20 | 2003-09-25 | Biopolymed Inc. | Preparation of g-csf stoichiometrically conjugated with biocompatible polymers at cystein residue |
US7423007B2 (en) | 2002-08-27 | 2008-09-09 | Biokine Therapeutics Ltd. | Cxcr4 antagonist and use thereof |
AU2003263552A1 (en) * | 2002-09-09 | 2004-03-29 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
US7785601B2 (en) | 2002-12-31 | 2010-08-31 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
US7695723B2 (en) | 2002-12-31 | 2010-04-13 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
CN102212019B (zh) | 2003-03-14 | 2015-05-27 | 蔚所番有限公司 | 支化水溶性聚合物及其缀合物 |
US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
CA2522345A1 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
EP2441465B1 (de) | 2003-10-24 | 2014-01-15 | Nora Therapeutics, Inc. | Zusammensetzungen und Verfahren für eine gesunde Schwangerschaft |
US8338373B2 (en) * | 2003-10-24 | 2012-12-25 | Nora Therapeutics, Inc. | Method for reducing the risk of spontaneous abortion in a human female subject |
US20090226397A1 (en) * | 2003-10-24 | 2009-09-10 | Nora Therapeutics, Inc. | Compositions and methods for reducing the likelihood of implantation failure or miscarriage in recipients of artificial insemination |
US7220407B2 (en) | 2003-10-27 | 2007-05-22 | Amgen Inc. | G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
NZ548123A (en) | 2004-01-08 | 2010-05-28 | Novo Nordisk As | O-linked glycosylation of peptides |
US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
EP3061461A1 (de) | 2004-10-29 | 2016-08-31 | ratiopharm GmbH | Remodellierung und glykopegylierung von fibroblasten-wachstumsfaktor (fgf) |
CA2586365A1 (en) | 2004-11-05 | 2006-05-26 | Northwestern University | Use of scf and g-csf in the treatment of cerebral ischemia and neurological disorders |
EP2514757A3 (de) | 2005-01-10 | 2014-03-05 | ratiopharm GmbH | Glycopegylierter Granulozyten-Kolonie stimulierende Faktor |
US9187546B2 (en) | 2005-04-08 | 2015-11-17 | Novo Nordisk A/S | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
EP1891231A4 (de) | 2005-05-25 | 2011-06-22 | Novo Nordisk As | Glykopegylierter faktor ix |
MX2007015156A (es) | 2005-06-01 | 2008-02-15 | Maxygen Holdings Ltd | Polipeptidos g-csf pegilados y metodos para la produccion de los mismos. |
KR100694994B1 (ko) * | 2005-06-13 | 2007-03-14 | 씨제이 주식회사 | 사람 과립구 콜로니 형성인자 동종체 |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
MX2008011407A (es) | 2006-03-06 | 2008-09-24 | Cadila Healthcare Ltd | Proceso para preparar g-csf humano. |
US9187532B2 (en) | 2006-07-21 | 2015-11-17 | Novo Nordisk A/S | Glycosylation of peptides via O-linked glycosylation sequences |
WO2008057683A2 (en) | 2006-10-03 | 2008-05-15 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates |
WO2008075371A2 (en) | 2006-12-21 | 2008-06-26 | Biokine Therapeutics Ltd. | T-140 peptide analogs having cxcr4 super-agonist activity for immunomodulation |
CA2682897C (en) | 2007-04-03 | 2016-11-22 | Biogenerix Ag | Methods of treatment using glycopegylated g-csf |
MX2009013259A (es) | 2007-06-12 | 2010-01-25 | Novo Nordisk As | Proceso mejorado para la produccion de azucares de nucleotidos. |
WO2009023566A2 (en) | 2007-08-09 | 2009-02-19 | Genzyme Corporation | Method of treating autoimmune disease with mesenchymal stem cells |
EP2578235A3 (de) | 2007-08-27 | 2013-08-28 | BioGeneriX AG | Flüssige Formulierung von G-CSF-Konjugat |
WO2009046015A2 (en) | 2007-09-30 | 2009-04-09 | University Of Florida Research Foundation, Inc. | Combination therapies for treating type 1 diabetes |
NZ586947A (en) | 2008-02-08 | 2012-11-30 | Ambrx Inc | Modified leptin polypeptides and their uses |
WO2009108806A1 (en) | 2008-02-27 | 2009-09-03 | Novo Nordisk A/S | Conjugated factor viii molecules |
EP2274325A4 (de) * | 2008-05-13 | 2011-05-25 | Nora Therapeutics Inc | Analoga von humanem g-csf und verfahren zur herstellung und anwendung davon |
AU2009274022B2 (en) | 2008-07-22 | 2016-06-02 | Menogenix, Inc. | Compositions and methods for treating symptoms associated with menopause, hormonal variations and arthritis |
EP2318029B1 (de) | 2008-07-23 | 2017-11-01 | Ambrx, Inc. | Modifizierte bovine g-csf-polypeptide und ihre verwendung |
US9151289B2 (en) | 2008-08-21 | 2015-10-06 | Cummins Inc. | Fuel pump |
EP2396023A2 (de) | 2009-02-11 | 2011-12-21 | Yeda Research and Development Co. Ltd. | Kurze peptide aus beta-defensin |
JP5715622B2 (ja) | 2009-06-14 | 2015-05-07 | バイオカイン セラピューティックス リミテッド | 血小板レベルを増大させるためのペプチド療法 |
CN102740840A (zh) | 2010-01-19 | 2012-10-17 | 韩美科学株式会社 | 长效g-csf缀合物的液体制剂 |
ES2639398T3 (es) | 2010-03-04 | 2017-10-26 | Pfenex Inc. | Método para producir proteína de interferón recombinante soluble sin desnaturalización |
AU2011235210B2 (en) | 2010-04-01 | 2015-07-16 | Pfenex Inc. | Methods for G-CSF production in a Pseudomonas host cell |
AR083006A1 (es) | 2010-09-23 | 2013-01-23 | Lilly Co Eli | Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas |
CN102796197B (zh) * | 2011-05-24 | 2013-12-25 | 杭州九源基因工程有限公司 | 一种hsa-gcsf突变体及其制备方法 |
EP2841084B1 (de) | 2012-04-24 | 2018-05-30 | Biokine Therapeutics Ltd. | Cxcr4 antagonist peptid zur verwendung in der behandlung von lungenkrebs |
WO2015057724A1 (en) | 2013-10-14 | 2015-04-23 | Nora Therapeutics, Inc. | Use of g-csf for treating or preventing villitis of unknown etiology in a human female |
MX2017016844A (es) | 2015-07-16 | 2018-08-15 | Biokine Therapeutics Ltd | Composiciones y procedimientos para tratar cancer. |
BR112018016924A2 (pt) | 2016-02-23 | 2019-01-02 | Biokine Therapeutics Ltd | método de seleção de regime de tratamento para indivíduo que tem leucemia mieloide aguda (lma), método de maximização de resposta ao tratamento de leucemia mieloide aguda (lma), método de tratamento de lma, antagonista de cxcr4 e agente quimioterápico no tratamento de lma |
WO2023196818A1 (en) | 2022-04-04 | 2023-10-12 | The Regents Of The University Of California | Genetic complementation compositions and methods |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
DK203187A (da) * | 1986-04-22 | 1987-10-23 | Immunex Corp | Human g-csf proteinekspression |
US5214132A (en) * | 1986-12-23 | 1993-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
DK174044B1 (da) * | 1986-12-23 | 2002-05-06 | Kyowa Hakko Kogyo Kk | Polypeptid afledt fra human granulocytkolonistimulerende faktor, og fremgangsmåde til fremstilling deraf, DNA kodende for nævnte polypeptid, rekombinant plasmid indeholdende nævnte DNA, og mikroorganismer indeholdende nævnte rekombinante plasmid....... |
AU621051B2 (en) * | 1987-04-28 | 1992-03-05 | Amgen, Inc. | Method for purifying granulocyte-macrophage colony stimulating factor |
US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
KR0133561B1 (ko) * | 1988-05-13 | 1998-04-21 | 스티븐 엠. 오드레 | 과립구 군체 자극인자의 정제방법 |
AU3754389A (en) * | 1988-05-31 | 1990-01-05 | Cetus Corporation | Process for recovering refractile bodies containing heterologous proteins from microbial hosts |
US5218092A (en) * | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
US5104651A (en) * | 1988-12-16 | 1992-04-14 | Amgen Inc. | Stabilized hydrophobic protein formulations of g-csf |
WO1990006952A1 (en) * | 1988-12-22 | 1990-06-28 | Kirin-Amgen, Inc. | Chemically modified granulocyte colony stimulating factor |
US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
DE4014750A1 (de) * | 1990-05-08 | 1991-11-14 | Boehringer Mannheim Gmbh | Muteine des granulozyten-stimulierenden faktors (g-csf) |
-
1991
- 1991-04-12 GB GB919107846A patent/GB9107846D0/en active Pending
- 1991-04-26 AU AU76284/91A patent/AU644647B2/en not_active Ceased
- 1991-04-29 BG BG094328A patent/BG94328A/bg unknown
- 1991-04-29 US US07/692,995 patent/US5416195A/en not_active Expired - Lifetime
- 1991-04-29 IE IE144091A patent/IE911440A1/en unknown
- 1991-04-29 EP EP91303868A patent/EP0459630B1/de not_active Expired - Lifetime
- 1991-04-29 AT AT91303868T patent/ATE169336T1/de not_active IP Right Cessation
- 1991-04-29 HU HU911440A patent/HUT60769A/hu unknown
- 1991-04-29 NO NO91911696A patent/NO911696L/no unknown
- 1991-04-29 NZ NZ237974A patent/NZ237974A/xx unknown
- 1991-04-29 DK DK91303868T patent/DK0459630T3/da active
- 1991-04-29 DE DE69129927T patent/DE69129927T2/de not_active Expired - Lifetime
- 1991-04-29 ES ES91303868T patent/ES2118737T3/es not_active Expired - Lifetime
- 1991-04-29 ZW ZW48/91A patent/ZW4891A1/xx unknown
- 1991-04-29 IL IL97993A patent/IL97993A0/xx unknown
- 1991-04-29 CA CA002041454A patent/CA2041454A1/en not_active Abandoned
- 1991-04-30 PT PT97529A patent/PT97529A/pt not_active Application Discontinuation
- 1991-04-30 CS CS911250A patent/CS125091A3/cs unknown
- 1991-04-30 TW TW080103367A patent/TW226022B/zh active
- 1991-04-30 KR KR1019910006926A patent/KR910018406A/ko not_active Application Discontinuation
- 1991-04-30 JP JP3228192A patent/JPH06100593A/ja active Pending
- 1991-04-30 FI FI912086A patent/FI912086A/fi unknown
-
1998
- 1998-08-06 GR GR980400784T patent/GR3027590T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NO911696L (no) | 1991-10-31 |
ES2118737T3 (es) | 1998-10-01 |
DE69129927D1 (de) | 1998-09-10 |
DK0459630T3 (da) | 1999-05-03 |
PT97529A (pt) | 1992-01-31 |
KR910018406A (ko) | 1991-11-30 |
US5416195A (en) | 1995-05-16 |
HUT60769A (en) | 1992-10-28 |
FI912086A (fi) | 1991-10-31 |
NZ237974A (en) | 1993-09-27 |
IE911440A1 (en) | 1991-11-06 |
FI912086A0 (fi) | 1991-04-30 |
CS125091A3 (en) | 1992-02-19 |
IL97993A0 (en) | 1992-06-21 |
GB9107846D0 (en) | 1991-05-29 |
CA2041454A1 (en) | 1991-10-31 |
AU7628491A (en) | 1991-11-14 |
DE69129927T2 (de) | 1999-04-01 |
ZW4891A1 (en) | 1992-01-01 |
EP0459630A3 (en) | 1992-10-21 |
GR3027590T3 (en) | 1998-11-30 |
AU644647B2 (en) | 1993-12-16 |
BG94328A (bg) | 1993-12-24 |
TW226022B (de) | 1994-07-01 |
EP0459630A2 (de) | 1991-12-04 |
EP0459630B1 (de) | 1998-08-05 |
NO911696D0 (no) | 1991-04-29 |
JPH06100593A (ja) | 1994-04-12 |
HU911440D0 (en) | 1991-11-28 |
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Legal Events
Date | Code | Title | Description |
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UEP | Publication of translation of european patent specification | ||
EELA | Cancelled due to lapse of time |