PT90697A - Processo para a transformacao de uma celula hospedeira com um vector recombinante - Google Patents

Processo para a transformacao de uma celula hospedeira com um vector recombinante

Info

Publication number
PT90697A
PT90697A PT90697A PT9069789A PT90697A PT 90697 A PT90697 A PT 90697A PT 90697 A PT90697 A PT 90697A PT 9069789 A PT9069789 A PT 9069789A PT 90697 A PT90697 A PT 90697A
Authority
PT
Portugal
Prior art keywords
transformation
host cell
clavulanic acid
recombinant
clavuligerus
Prior art date
Application number
PT90697A
Other languages
English (en)
Other versions
PT90697B (pt
Inventor
John Edward Hodgson
Alison Jane Earl
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10637947&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT90697(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of PT90697A publication Critical patent/PT90697A/pt
Publication of PT90697B publication Critical patent/PT90697B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
PT90697A 1988-06-02 1989-06-01 Processo para a transformacao de uma celula hospedeira com um vector recombinante e metodo para a producao de acido clavulanico por meio de cultura dos transformantes assim obtidos PT90697B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888813055A GB8813055D0 (en) 1988-06-02 1988-06-02 Novel substance

Publications (2)

Publication Number Publication Date
PT90697A true PT90697A (pt) 1989-12-29
PT90697B PT90697B (pt) 1995-06-30

Family

ID=10637947

Family Applications (1)

Application Number Title Priority Date Filing Date
PT90697A PT90697B (pt) 1988-06-02 1989-06-01 Processo para a transformacao de uma celula hospedeira com um vector recombinante e metodo para a producao de acido clavulanico por meio de cultura dos transformantes assim obtidos

Country Status (9)

Country Link
US (1) US5759831A (pt)
EP (1) EP0349121B1 (pt)
JP (1) JP3289726B2 (pt)
AT (1) ATE140971T1 (pt)
DE (1) DE68926893T2 (pt)
ES (1) ES2090036T3 (pt)
GB (1) GB8813055D0 (pt)
GR (1) GR3021071T3 (pt)
PT (1) PT90697B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8813055D0 (en) * 1988-06-02 1988-07-06 Beecham Group Plc Novel substance
US6037156A (en) * 1989-05-30 2000-03-14 Beecham Group P.L.C. DNA molecules and vectors encoding clavulanic acid biosynthesis enzymes
WO1994012654A1 (en) * 1992-12-02 1994-06-09 Smithkline Beecham Plc Process for preparing clavulanic acid
GB9302041D0 (en) 1993-02-02 1993-03-17 Smithkline Peecham P L C Novel compounds
GB9315393D0 (en) * 1993-07-24 1993-09-08 Smithkline Beecham Plc Novel product
US20030219867A1 (en) * 1993-07-24 2003-11-27 Smithkline Beecham Plc Clavulanic acid dehydrogenase, preparation and use for the production of clavulanic acid
US6589775B1 (en) 1993-10-08 2003-07-08 The Governors Of The University Of Alberta DNA sequence encoding enzymes of clavulanic acid biosynthesis
US6232106B1 (en) 1993-10-08 2001-05-15 The Governors Of The University Of Alberta DNA sequence encoding enzymes of clavulanic acid biosynthesis
GB9511679D0 (en) * 1995-06-09 1995-08-02 Smithkline Beecham Plc Novel process
ES2131001B1 (es) * 1997-06-16 2000-04-01 Antibioticos Sau Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus.
WO1999001566A1 (en) * 1997-07-03 1999-01-14 Dsm N.V. PREPARATION OF ENZYME WITH REDUCED β-LACTAMASE ACTIVITY
WO2001019959A1 (en) * 1999-09-16 2001-03-22 The Johns Hopkins University Improvement of clavulanic acid production
CA2465839A1 (en) * 2001-11-07 2003-05-15 Smithkline Beecham P.L.C. Polynucleotides and polypeptides involved in clavulinic acid biosynthesis and use thereof
CN109913392A (zh) * 2019-03-30 2019-06-21 山东睿智医药科技有限公司 高产克拉维酸的棒状链霉菌菌株、其胁迫选育方法及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0061253A3 (en) * 1981-03-18 1982-12-08 Beecham Group Plc Process for the transfer of genetic material into actinomycete cells, prepared cells and method of culturing these cells and isolating a metabolite
GB8521516D0 (en) * 1985-08-29 1985-10-02 Beecham Group Plc Compounds
EP0262154A1 (en) * 1985-12-17 1988-04-06 Lubrizol Genetics Inc. Isolation of genes for biosynthesis of polyketide antibiotics
EP0233715B1 (en) * 1986-01-31 1994-05-25 BEECHAM GROUP plc Isolation and expression of genes involved in the biosynthesis of beta-lactams
GB8813055D0 (en) * 1988-06-02 1988-07-06 Beecham Group Plc Novel substance

Also Published As

Publication number Publication date
PT90697B (pt) 1995-06-30
GB8813055D0 (en) 1988-07-06
EP0349121B1 (en) 1996-07-31
JPH0242989A (ja) 1990-02-13
ATE140971T1 (de) 1996-08-15
DE68926893T2 (de) 1997-01-23
JP3289726B2 (ja) 2002-06-10
EP0349121A3 (en) 1990-09-12
EP0349121A2 (en) 1990-01-03
GR3021071T3 (en) 1996-12-31
US5759831A (en) 1998-06-02
DE68926893D1 (de) 1996-09-05
ES2090036T3 (es) 1996-10-16

Similar Documents

Publication Publication Date Title
PT90697A (pt) Processo para a transformacao de uma celula hospedeira com um vector recombinante
AU692678C (en) Structural gene of pneumococcal protein
DE88166T1 (de) Verfahren zum exprimieren eines gens.
ID24149A (id) PROSES FERMENTASI UNTUK PEMBUATAN ASAM D-PANTOTENIK DENGAN MENGUATKAN GEN panD PADA MIKROORGANISME
WO1994020617A3 (en) Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
AU7628491A (en) Polypeptides
ATE68204T1 (de) Transformation von hefe des genus pichia.
ES8609477A1 (es) Un metodo para aislar material genetico a partir de cepas delevaduras del genero pichia
CA2045175A1 (en) Production of proteins using homologous recombination
DK1025211T3 (da) Hyaluronansyntasegen og anvendelser deraf
AU7450887A (en) Novel human TNF polypeptide mutants and DNAs encoding said mutants
AU587827B2 (en) Oligopeptide derivatives, their production and their use as surfactantes kind to the skin
AU4444389A (en) Process for the expression of a recombinant gene
ATE129524T1 (de) Herstellung von copolymeren.
AU2001274537A1 (en) Novel glucose-6-phosphate dehydrogenase
SI0677584T1 (en) Stable mutants of D-N-alpha-carbamylase
KR940002352A (ko) 디(d)-아미노산 옥시다제 생산성 형질전환체
EP1149912A3 (en) Polyhydroxyalkanoate synthase and gene encoding the same
AU1462688A (en) Process for the production of proteins
AU586874B2 (en) Invasive microorganisms
CA2108358A1 (en) Gene expression in bacilli
EP0284205A3 (en) Carbomycin biosynthetic gene, designated carg, for use in streptomyces and other organisms
PT81052B (pt) Processo de preparacao de saccharomyces recombinantes
ATE193728T1 (de) Für eine esterase kodierendes gen und dieses gen enthaltender mikroorganismus
DE69008400D1 (de) Herstellung von 2-Desoxyuridin.

Legal Events

Date Code Title Description
MM3A Annulment or lapse

Effective date: 20050620