DE68926893D1 - Verfahren zur Herstellung von clavulanic Säure - Google Patents

Verfahren zur Herstellung von clavulanic Säure

Info

Publication number
DE68926893D1
DE68926893D1 DE68926893T DE68926893T DE68926893D1 DE 68926893 D1 DE68926893 D1 DE 68926893D1 DE 68926893 T DE68926893 T DE 68926893T DE 68926893 T DE68926893 T DE 68926893T DE 68926893 D1 DE68926893 D1 DE 68926893D1
Authority
DE
Germany
Prior art keywords
clavulanic acid
production
clavuligerus
dna
sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68926893T
Other languages
English (en)
Other versions
DE68926893T2 (de
Inventor
John Edward Hodgson
Alison Jane Earl
Ian D Normansell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10637947&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE68926893(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of DE68926893D1 publication Critical patent/DE68926893D1/de
Publication of DE68926893T2 publication Critical patent/DE68926893T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
DE68926893T 1988-06-02 1989-05-30 Verfahren zur Herstellung von clavulanic Säure Expired - Lifetime DE68926893T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888813055A GB8813055D0 (en) 1988-06-02 1988-06-02 Novel substance

Publications (2)

Publication Number Publication Date
DE68926893D1 true DE68926893D1 (de) 1996-09-05
DE68926893T2 DE68926893T2 (de) 1997-01-23

Family

ID=10637947

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68926893T Expired - Lifetime DE68926893T2 (de) 1988-06-02 1989-05-30 Verfahren zur Herstellung von clavulanic Säure

Country Status (9)

Country Link
US (1) US5759831A (de)
EP (1) EP0349121B1 (de)
JP (1) JP3289726B2 (de)
AT (1) ATE140971T1 (de)
DE (1) DE68926893T2 (de)
ES (1) ES2090036T3 (de)
GB (1) GB8813055D0 (de)
GR (1) GR3021071T3 (de)
PT (1) PT90697B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8813055D0 (en) * 1988-06-02 1988-07-06 Beecham Group Plc Novel substance
US6037156A (en) * 1989-05-30 2000-03-14 Beecham Group P.L.C. DNA molecules and vectors encoding clavulanic acid biosynthesis enzymes
EP0673432B1 (de) * 1992-12-02 1999-03-24 Smithkline Beecham Plc Verfahren zur herstellung von clavulansäure
GB9302041D0 (en) 1993-02-02 1993-03-17 Smithkline Peecham P L C Novel compounds
GB9315393D0 (en) * 1993-07-24 1993-09-08 Smithkline Beecham Plc Novel product
US20030219867A1 (en) * 1993-07-24 2003-11-27 Smithkline Beecham Plc Clavulanic acid dehydrogenase, preparation and use for the production of clavulanic acid
US6589775B1 (en) 1993-10-08 2003-07-08 The Governors Of The University Of Alberta DNA sequence encoding enzymes of clavulanic acid biosynthesis
US6232106B1 (en) 1993-10-08 2001-05-15 The Governors Of The University Of Alberta DNA sequence encoding enzymes of clavulanic acid biosynthesis
GB9511679D0 (en) 1995-06-09 1995-08-02 Smithkline Beecham Plc Novel process
ES2131001B1 (es) * 1997-06-16 2000-04-01 Antibioticos Sau Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus.
AU9254498A (en) * 1997-07-03 1999-01-25 Gist-Brocades B.V. Preparation of enzyme with reduced beta-lactamase activity
WO2001019959A1 (en) * 1999-09-16 2001-03-22 The Johns Hopkins University Improvement of clavulanic acid production
AU2002341185A1 (en) * 2001-11-07 2003-05-19 Smithkline Beecham P.L.C. Polynucleotides and polypeptides involved in clavulinic acid biosynthesis and use thereof
CN109913392A (zh) * 2019-03-30 2019-06-21 山东睿智医药科技有限公司 高产克拉维酸的棒状链霉菌菌株、其胁迫选育方法及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0061253A3 (de) * 1981-03-18 1982-12-08 Beecham Group Plc Verfahren zum Transferieren von genetischem Material in Actinomyceten-Zellen, hergestellte Zellen und Verfahren zur Züchtung dieser Zellen und zur Isolierung eines Stoffwechselproduktes
GB8521516D0 (en) * 1985-08-29 1985-10-02 Beecham Group Plc Compounds
EP0463707A1 (de) * 1985-12-17 1992-01-02 Lubrizol Genetics Inc. Herstellung von Polyketid-Antibiotika
EP0233715B1 (de) * 1986-01-31 1994-05-25 BEECHAM GROUP plc Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen
GB8813055D0 (en) * 1988-06-02 1988-07-06 Beecham Group Plc Novel substance

Also Published As

Publication number Publication date
DE68926893T2 (de) 1997-01-23
EP0349121A2 (de) 1990-01-03
EP0349121B1 (de) 1996-07-31
GR3021071T3 (en) 1996-12-31
GB8813055D0 (en) 1988-07-06
PT90697B (pt) 1995-06-30
ATE140971T1 (de) 1996-08-15
EP0349121A3 (en) 1990-09-12
ES2090036T3 (es) 1996-10-16
PT90697A (pt) 1989-12-29
JPH0242989A (ja) 1990-02-13
US5759831A (en) 1998-06-02
JP3289726B2 (ja) 2002-06-10

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Legal Events

Date Code Title Description
8363 Opposition against the patent