TW211568B - - Google Patents

Download PDF

Info

Publication number
TW211568B
TW211568B TW081110173A TW81110173A TW211568B TW 211568 B TW211568 B TW 211568B TW 081110173 A TW081110173 A TW 081110173A TW 81110173 A TW81110173 A TW 81110173A TW 211568 B TW211568 B TW 211568B
Authority
TW
Taiwan
Prior art keywords
compound
cyclopropyl
group
quinazoline
gas
Prior art date
Application number
TW081110173A
Other languages
English (en)
Chinese (zh)
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of TW211568B publication Critical patent/TW211568B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW081110173A 1991-12-20 1992-12-18 TW211568B (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK912042A DK204291D0 (da) 1991-12-20 1991-12-20 Heterocykliske forbindelser deres fremstilling og anvendelse

Publications (1)

Publication Number Publication Date
TW211568B true TW211568B (fi) 1993-08-21

Family

ID=8109668

Family Applications (1)

Application Number Title Priority Date Filing Date
TW081110173A TW211568B (fi) 1991-12-20 1992-12-18

Country Status (12)

Country Link
EP (1) EP0619820A1 (fi)
JP (1) JPH07502278A (fi)
AU (1) AU673814B2 (fi)
CA (1) CA2125854A1 (fi)
DK (1) DK204291D0 (fi)
FI (1) FI942963A0 (fi)
IL (1) IL104099A (fi)
NO (1) NO942301L (fi)
NZ (1) NZ246558A (fi)
TW (1) TW211568B (fi)
WO (1) WO1993013103A1 (fi)
ZA (1) ZA929770B (fi)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK151890D0 (da) * 1990-06-22 1990-06-22 Ferrosan As Heterocykliske forbindelser deres fremstilling og brug
CN1052724C (zh) * 1996-07-01 2000-05-24 瑞安大药厂股份有限公司 新的光学活性的2,3－二氢咪唑并[1,2－c]喹唑啉衍生物及其制备方法和用途
US8053762B2 (en) 2005-12-13 2011-11-08 Lg Chem, Ltd. Imidazoquinazoline derivative, process for preparing the same, and organic electronic device using the same
EP2125750B1 (en) 2007-02-26 2014-05-21 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1
AR069207A1 (es) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
JP5490014B2 (ja) 2007-12-11 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤
JP5379160B2 (ja) 2008-07-25 2013-12-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
JP5777030B2 (ja) 2008-07-25 2015-09-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤
EP2393807B1 (en) 2009-02-04 2013-08-14 Boehringer Ingelheim International GmbH Cyclic inhibitors of 11 -hydroxysteroid dehydrogenase 1
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
WO2011011123A1 (en) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
JP5749263B2 (ja) 2009-07-01 2015-07-15 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
JP5813106B2 (ja) 2010-06-25 2015-11-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン
AU2011325286B2 (en) 2010-11-02 2015-04-16 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of metabolic disorders
CN114369096A (zh) * 2020-10-16 2022-04-19 上海迪诺医药科技有限公司 三杂环衍生物、其药物组合物及应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0274009B1 (en) * 1985-10-17 1992-09-09 Novo Nordisk A/S Oxadiazolylacetonitriles, their preparation and use
DK155524C (da) * 1987-03-18 1989-09-11 Ferrosan As Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse
DK443589D0 (da) * 1989-09-08 1989-09-08 Ferrosan As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK151890D0 (da) * 1990-06-22 1990-06-22 Ferrosan As Heterocykliske forbindelser deres fremstilling og brug

Also Published As

Publication number Publication date
FI942963A (fi) 1994-06-20
IL104099A (en) 1996-07-23
ZA929770B (en) 1994-06-17
AU673814B2 (en) 1996-11-28
NZ246558A (en) 1995-07-26
AU3344893A (en) 1993-07-28
IL104099A0 (en) 1993-05-13
DK204291D0 (da) 1991-12-20
EP0619820A1 (en) 1994-10-19
NO942301D0 (no) 1994-06-17
NO942301L (no) 1994-08-19
JPH07502278A (ja) 1995-03-09
FI942963A0 (fi) 1994-06-20
CA2125854A1 (en) 1993-07-08
WO1993013103A1 (en) 1993-07-08

Similar Documents

Publication Publication Date Title
TW211568B (fi)
JP4074509B2 (ja) 抗癌性化合物を製造するための方法と中間体
ES2367666T3 (es) Derivados de [4,5']bipirimidinil-6,4'-diamina como inhibidores de proteína quinasa.
JP6976947B2 (ja) 自己免疫疾患の処置に有用なビピラゾリル誘導体
TW209862B (fi)
CN103403003B (zh) 桥连哌啶衍生物
CA2673003A1 (en) Quinazolines for pdk1 inhibition
CA2045359C (en) 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
EA005407B1 (ru) Производные бензоимидазола, используемые в качестве антипролиферативного средства
CN109890820A (zh) 用作神经营养因子酪氨酸激酶受体抑制剂的氨基吡唑并嘧啶化合物
CN103889987A (zh) 作为btk-抑制剂的4-咪唑并哒嗪-1-基-苯甲酰胺类和4-咪唑并三嗪-1-基-苯甲酰胺类
CA2727251A1 (en) 2 -arylaminoquinazolines for treating proliferative diseases
EA017442B1 (ru) ПРОИЗВОДНЫЕ 2-АРИЛ-6-ФЕНИЛИМИДАЗО[1,2-a]ПИРИДИНОВ, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В ТЕРАПИИ
BR112015019627B1 (pt) Compostos de amidas heterocíclicas, composições farmacêuticas compreendendo ditos compostos e usos dos mesmos para tratar colite ulcerativa, doença de crohn, artrite reumatoide, psoríase, espondiloartrite, artrite idiopática juvenil de aparecimento sistêmico (sojia), osteoartrite e esclerose múltipla
CN104341425B (zh) 氘代乙炔衍生物、其药物组合物及应用
BR112015007731B1 (pt) Composto, composição farmacêutica que o compreende e uso do mesmo
DE3883033T2 (de) Heterocyclische Verbindungen und ihre Herstellung und Anwendung.
US8957077B2 (en) Pyrazolopyrimidine PDE 10 inhibitors
WO2012044090A2 (ko) 단백질 키나제 억제 활성을 갖는 신규한 아미노퀴나졸린 화합물
CN111410659B (zh) Pde9抑制剂及其用途
CN111406054A (zh) 作为组蛋白脱乙酰基酶6抑制剂的1，2，4-噁二唑衍生物
JP2002510695A (ja) 副腎皮質刺激ホルモン放出因子（ＣＲＦ）拮抗剤としてのチアゾロ［４，５−ｄ］ピリミジンおよびピリジン
WO2021228248A1 (zh) 氮杂稠环酰胺类化合物及其用途
TW542833B (en) Benzoxazinone dopamine D4 receptor antagonists
JP2017122103A (ja) うつ病、糖尿病及びパーキンソン病のような幾つかの障害の処置において使用するためのｔａａｒ調節薬としてのピラゾールカルボキサミド誘導体