TW204348B - - Google Patents

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Publication number
TW204348B
TW204348B TW080103191A TW80103191A TW204348B TW 204348 B TW204348 B TW 204348B TW 080103191 A TW080103191 A TW 080103191A TW 80103191 A TW80103191 A TW 80103191A TW 204348 B TW204348 B TW 204348B
Authority
TW
Taiwan
Prior art keywords
chain
straight
group
atom
hydrogen atom
Prior art date
Application number
TW080103191A
Other languages
English (en)
Chinese (zh)
Original Assignee
Nissan Chemical Ind Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Ind Ltd filed Critical Nissan Chemical Ind Ltd
Application granted granted Critical
Publication of TW204348B publication Critical patent/TW204348B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
TW080103191A 1990-04-25 1991-04-23 TW204348B (Direct)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10991490 1990-04-25

Publications (1)

Publication Number Publication Date
TW204348B true TW204348B (Direct) 1993-04-21

Family

ID=14522343

Family Applications (1)

Application Number Title Priority Date Filing Date
TW080103191A TW204348B (Direct) 1990-04-25 1991-04-23

Country Status (17)

Country Link
US (3) US5202323A (Direct)
EP (1) EP0482208B1 (Direct)
JP (1) JPH07107055B2 (Direct)
KR (1) KR970002876B1 (Direct)
AT (1) ATE194835T1 (Direct)
AU (1) AU634655B2 (Direct)
CA (1) CA2053863C (Direct)
DE (1) DE69132329T2 (Direct)
DK (1) DK0482208T3 (Direct)
ES (1) ES2149761T3 (Direct)
GR (1) GR3034331T3 (Direct)
HU (1) HU208124B (Direct)
RU (1) RU2054004C1 (Direct)
TW (1) TW204348B (Direct)
UA (1) UA27031A1 (Direct)
WO (1) WO1991016314A1 (Direct)
ZA (1) ZA913134B (Direct)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
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WO1991016314A1 (en) * 1990-04-25 1991-10-31 Nissan Chemical Industries Ltd. Pyridazinone derivative
US5403590A (en) * 1992-12-21 1995-04-04 New England Deaconess Hospital Corporation Method of pulsatile drug infusion
JP3080131B2 (ja) 1993-06-29 2000-08-21 日産化学工業株式会社 ピリダジノン誘導体
IL110040A (en) * 1993-06-29 2000-07-16 Nissan Chemical Ind Ltd Pyridazinone derivatives their preparation and pharmaceutical compositions comprising them
KR960704853A (ko) * 1993-09-06 1996-10-09 아끼자와 다까시 피리다지논 유도체 또는 그의 염, 그의 제조 방법 및 그를 함유하는 항쇼크제 (Pyridazinone Derivatives or their Salts, Processes for their Production, and Anti-Shock Agents Containing Them)
TW326041B (en) * 1993-12-16 1998-02-01 Nippon Nouyaku Kk Pyridazinone derivatives, their production process and their use for inhibition of platelet aggregation
DK0742211T3 (da) * 1994-01-25 2000-08-14 Nissan Chemical Ind Ltd Pyridazinonderivater
IL112695A (en) * 1994-02-22 1999-04-11 Green Cross Corp Pharmaceutical compositions containing pyridazinone derivatives
GB9514160D0 (en) * 1994-07-25 1995-09-13 Zeneca Ltd Aromatic compounds
US5670504A (en) * 1995-02-23 1997-09-23 Merck & Co. Inc. 2,6-diaryl pyridazinones with immunosuppressant activity
TW434240B (en) * 1995-06-20 2001-05-16 Zeneca Ltd Aromatic compounds, preparation thereof and pharmaceutical composition comprising same
KR100365312B1 (ko) 1996-06-27 2003-03-06 얀센 파마슈티카 엔.브이. N-[4-(헤테로아릴메틸)페닐]헤테로아릴아민
TW482675B (en) * 1997-01-31 2002-04-11 Green Cross Corp Compositions for oral administration containing pyridazinone compounds technical field of the invention
EP1025847B1 (en) 1997-08-28 2005-10-26 Nissan Chemical Industries, Ltd. Neovascularization promoters and neovascularization potentiators
RU2211217C2 (ru) * 1998-06-05 2003-08-27 Эгиш Дьёдьсердьяр Рт. Способ получения 5-хлор-4-аминозамещенного производного 3(2н)-пиридазинона
PT1123704E (pt) * 1998-09-01 2004-10-29 Nissan Chemical Ind Ltd Agente terapeutico para a estenose da cauda equina
IL143530A0 (en) * 1998-12-07 2002-04-21 Nissan Chemical Ind Ltd Pyridazinone derivatives
DE20009841U1 (de) * 2000-05-31 2001-10-25 Phyt-Immun GmbH, 66424 Homburg Nasensalbe auf Basis von Vaselin
WO2002085897A1 (en) * 2001-04-05 2002-10-31 Alangudi Sankaranarayanan Heterocyclic compounds for aging-related and diabetic vascular complications
US7399864B2 (en) * 2001-05-02 2008-07-15 Otsuka Pharmaceutical Co., Ltd. Process for producing carbostyril derivatives
US20050101631A1 (en) * 2002-08-01 2005-05-12 Otsuka Pharmaceuticals Company Process for producing carbostyril derivatives
JP4510384B2 (ja) 2001-05-23 2010-07-21 田辺三菱製薬株式会社 骨折治癒促進用組成物
ES2427930T3 (es) 2001-05-23 2013-11-04 Mitsubishi Tanabe Pharma Corporation Composición terapéutica para el tratamiento regenerativo de enfermedades de los cartílagos
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CA2526586C (en) * 2003-09-09 2010-03-16 Fumapharm Ag The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma
CA2549672C (en) * 2003-12-26 2010-06-22 Nissan Chemical Industries, Ltd. Antineutrophilia agent using 3(2h)-pyridazinone compounds
KR20070029133A (ko) * 2004-02-09 2007-03-13 닛산 가가쿠 고교 가부시키 가이샤 혈관 내막 비후 억제약
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
JPWO2010074090A1 (ja) * 2008-12-25 2012-06-21 日産化学工業株式会社 ピリダジン−３（２ｈ）−オン化合物塩酸塩の結晶及びその製造方法
DK2448938T5 (en) 2009-06-29 2015-10-05 Incyte Corp Pyrimidinones AS PI3K inhibitors
WO2011075630A1 (en) * 2009-12-18 2011-06-23 Incyte Corporation Substituted fused aryl and heteroaryl derivatives as pi3k inhibitors
US8759359B2 (en) 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
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AR081823A1 (es) 2010-04-14 2012-10-24 Incyte Corp DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
AR084366A1 (es) 2010-12-20 2013-05-08 Incyte Corp N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k
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US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
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JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
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WO1991016314A1 (en) * 1990-04-25 1991-10-31 Nissan Chemical Industries Ltd. Pyridazinone derivative

Also Published As

Publication number Publication date
RU2054004C1 (ru) 1996-02-10
HU913497D0 (en) 1992-01-28
ZA913134B (en) 1992-04-29
KR920701169A (ko) 1992-08-11
US5318968A (en) 1994-06-07
EP0482208A4 (en) 1992-10-07
KR970002876B1 (ko) 1997-03-12
ES2149761T3 (es) 2000-11-16
AU7651191A (en) 1991-11-11
GR3034331T3 (en) 2000-12-29
DE69132329D1 (de) 2000-08-24
HUT60253A (en) 1992-08-28
WO1991016314A1 (en) 1991-10-31
JPH07107055B1 (Direct) 1995-11-15
UA27031A1 (uk) 2000-02-28
US5314883A (en) 1994-05-24
US5202323A (en) 1993-04-13
JPH07107055B2 (ja) 1995-11-15
EP0482208B1 (en) 2000-07-19
DE69132329T2 (de) 2000-11-30
CA2053863C (en) 1996-10-29
HU208124B (en) 1993-08-30
ATE194835T1 (de) 2000-08-15
AU634655B2 (en) 1993-02-25
CA2053863A1 (en) 1991-10-26
EP0482208A1 (en) 1992-04-29
DK0482208T3 (da) 2000-09-18

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