TW202506706A - 環狀胜肽化合物的製造方法 - Google Patents

環狀胜肽化合物的製造方法 Download PDF

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Publication number
TW202506706A
TW202506706A TW113114671A TW113114671A TW202506706A TW 202506706 A TW202506706 A TW 202506706A TW 113114671 A TW113114671 A TW 113114671A TW 113114671 A TW113114671 A TW 113114671A TW 202506706 A TW202506706 A TW 202506706A
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TW
Taiwan
Prior art keywords
group
peptide compound
solvent
formula
alkyl
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TW113114671A
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English (en)
Chinese (zh)
Inventor
堀部貴大
椎名淳一
王胤力
猪俣祐貴
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日商中外製藥股份有限公司
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Application filed by 日商中外製藥股份有限公司 filed Critical 日商中外製藥股份有限公司
Publication of TW202506706A publication Critical patent/TW202506706A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
TW113114671A 2023-04-20 2024-04-19 環狀胜肽化合物的製造方法 TW202506706A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2023-069189 2023-04-20
JP2023069189 2023-04-20

Publications (1)

Publication Number Publication Date
TW202506706A true TW202506706A (zh) 2025-02-16

Family

ID=93152939

Family Applications (1)

Application Number Title Priority Date Filing Date
TW113114671A TW202506706A (zh) 2023-04-20 2024-04-19 環狀胜肽化合物的製造方法

Country Status (9)

Country Link
EP (1) EP4678652A1 (https=)
JP (1) JPWO2024219480A1 (https=)
KR (1) KR20250174064A (https=)
CN (1) CN120936619A (https=)
AU (1) AU2024257451A1 (https=)
IL (1) IL323506A (https=)
MX (1) MX2025012255A (https=)
TW (1) TW202506706A (https=)
WO (1) WO2024219480A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer
CN119751564B (zh) * 2024-12-05 2025-11-11 浙江大学 一种环肽化合物合成方法及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506372D0 (en) * 1995-03-29 1995-05-17 Fujisawa Pharmaceutical Co New peptide compounds
KR20210139366A (ko) 2019-03-15 2021-11-22 추가이 세이야쿠 가부시키가이샤 방향족 아미노산 유도체의 제조 방법
JPWO2022138891A1 (https=) * 2020-12-25 2022-06-30
TW202309065A (zh) * 2021-05-07 2023-03-01 日商中外製藥股份有限公司 包含n-取代胺基酸殘基之環狀化合物的製造方法
AR125796A1 (es) 2021-05-07 2023-08-16 Chugai Pharmaceutical Co Ltd Compuesto cíclico que tiene una acción inhibitoria selectiva en kras sobre hras y nras
AU2022270498A1 (en) * 2021-05-07 2023-10-05 Chugai Seiyaku Kabushiki Kaisha Preparation containing cyclic peptide compound and method for producing same

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Publication number Publication date
IL323506A (en) 2025-11-01
AU2024257451A1 (en) 2025-10-09
CN120936619A (zh) 2025-11-11
KR20250174064A (ko) 2025-12-11
WO2024219480A1 (ja) 2024-10-24
JPWO2024219480A1 (https=) 2024-10-24
EP4678652A1 (en) 2026-01-14
MX2025012255A (es) 2025-11-03

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