KR20250174064A - 고리형 펩타이드 화합물의 제조 방법 - Google Patents

고리형 펩타이드 화합물의 제조 방법

Info

Publication number
KR20250174064A
KR20250174064A KR1020257037736A KR20257037736A KR20250174064A KR 20250174064 A KR20250174064 A KR 20250174064A KR 1020257037736 A KR1020257037736 A KR 1020257037736A KR 20257037736 A KR20257037736 A KR 20257037736A KR 20250174064 A KR20250174064 A KR 20250174064A
Authority
KR
South Korea
Prior art keywords
peptide compound
group
crystal
alkyl
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020257037736A
Other languages
English (en)
Korean (ko)
Inventor
다카히로 호리베
준이치 시나
인리 왕
유키 이노마타
Original Assignee
추가이 세이야쿠 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 추가이 세이야쿠 가부시키가이샤 filed Critical 추가이 세이야쿠 가부시키가이샤
Publication of KR20250174064A publication Critical patent/KR20250174064A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
KR1020257037736A 2023-04-20 2024-04-19 고리형 펩타이드 화합물의 제조 방법 Pending KR20250174064A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2023-069189 2023-04-20
JP2023069189 2023-04-20
PCT/JP2024/015529 WO2024219480A1 (ja) 2023-04-20 2024-04-19 環状ペプチド化合物の製造方法

Publications (1)

Publication Number Publication Date
KR20250174064A true KR20250174064A (ko) 2025-12-11

Family

ID=93152939

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020257037736A Pending KR20250174064A (ko) 2023-04-20 2024-04-19 고리형 펩타이드 화합물의 제조 방법

Country Status (9)

Country Link
EP (1) EP4678652A1 (https=)
JP (1) JPWO2024219480A1 (https=)
KR (1) KR20250174064A (https=)
CN (1) CN120936619A (https=)
AU (1) AU2024257451A1 (https=)
IL (1) IL323506A (https=)
MX (1) MX2025012255A (https=)
TW (1) TW202506706A (https=)
WO (1) WO2024219480A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer
CN119751564B (zh) * 2024-12-05 2025-11-11 浙江大学 一种环肽化合物合成方法及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022234853A1 (ja) 2021-05-07 2022-11-10 中外製薬株式会社 Ｈｒａｓおよびｎｒａｓに対して選択的なｋｒａｓ阻害作用を有する環状化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506372D0 (en) * 1995-03-29 1995-05-17 Fujisawa Pharmaceutical Co New peptide compounds
KR20210139366A (ko) 2019-03-15 2021-11-22 추가이 세이야쿠 가부시키가이샤 방향족 아미노산 유도체의 제조 방법
JPWO2022138891A1 (https=) * 2020-12-25 2022-06-30
TW202309065A (zh) * 2021-05-07 2023-03-01 日商中外製藥股份有限公司 包含n-取代胺基酸殘基之環狀化合物的製造方法
AU2022270498A1 (en) * 2021-05-07 2023-10-05 Chugai Seiyaku Kabushiki Kaisha Preparation containing cyclic peptide compound and method for producing same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022234853A1 (ja) 2021-05-07 2022-11-10 中外製薬株式会社 Ｈｒａｓおよびｎｒａｓに対して選択的なｋｒａｓ阻害作用を有する環状化合物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Nat. Rev. Drug Discov. 2014 Dec; 13(12): 928-942.
Nat. Rev. Drug Discov. 2014 Nov; 13(11): 828-851.
Nat. Rev. Drug Discov. 2016 Nov; 15(11): 771-785.

Also Published As

Publication number Publication date
IL323506A (en) 2025-11-01
AU2024257451A1 (en) 2025-10-09
CN120936619A (zh) 2025-11-11
WO2024219480A1 (ja) 2024-10-24
TW202506706A (zh) 2025-02-16
JPWO2024219480A1 (https=) 2024-10-24
EP4678652A1 (en) 2026-01-14
MX2025012255A (es) 2025-11-03

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Q12 Application published

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