TW202317753A - 經武裝之嵌合受體及其使用方法 - Google Patents
經武裝之嵌合受體及其使用方法 Download PDFInfo
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- TW202317753A TW202317753A TW111122516A TW111122516A TW202317753A TW 202317753 A TW202317753 A TW 202317753A TW 111122516 A TW111122516 A TW 111122516A TW 111122516 A TW111122516 A TW 111122516A TW 202317753 A TW202317753 A TW 202317753A
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- A—HUMAN NECESSITIES
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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- A—HUMAN NECESSITIES
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- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A—HUMAN NECESSITIES
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- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/35—Cytokines
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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- A61K40/4261—Proteoglycans, e.g. glypican, brevican or CSPG4
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
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- C07K14/5443—IL-15
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/53—Liver
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Dermatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163211468P | 2021-06-16 | 2021-06-16 | |
| US63/211,468 | 2021-06-16 | ||
| US202263305155P | 2022-01-31 | 2022-01-31 | |
| US63/305,155 | 2022-01-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202317753A true TW202317753A (zh) | 2023-05-01 |
Family
ID=84526773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW111122516A TW202317753A (zh) | 2021-06-16 | 2022-06-16 | 經武裝之嵌合受體及其使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20240277766A1 (enExample) |
| EP (1) | EP4355341A4 (enExample) |
| JP (1) | JP2024524922A (enExample) |
| KR (1) | KR20240022575A (enExample) |
| AU (1) | AU2022294896A1 (enExample) |
| CA (1) | CA3221897A1 (enExample) |
| IL (1) | IL309161A (enExample) |
| TW (1) | TW202317753A (enExample) |
| WO (1) | WO2022266396A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020092839A1 (en) | 2018-10-31 | 2020-05-07 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| EP3873540A4 (en) | 2018-10-31 | 2022-07-27 | Mayo Foundation for Medical Education and Research | METHODS AND MATERIALS FOR THE TREATMENT OF CANCER |
| WO2024102943A1 (en) * | 2022-11-09 | 2024-05-16 | Senti Biosciences, Inc. | Armed chimeric receptors and methods of use thereof |
| CN120112547A (zh) * | 2022-11-16 | 2025-06-06 | 瑞泽恩制药公司 | 包含膜结合il-12和蛋白酶可裂解接头的嵌合蛋白 |
| WO2025106924A1 (en) * | 2023-11-16 | 2025-05-22 | Senti Biosciences, Inc. | Methods of enhancing engineered immune cell cytotoxicity |
| WO2025179221A1 (en) * | 2024-02-22 | 2025-08-28 | Senti Biosciences, Inc. | Compositions and methods for armored cell based therapies |
| WO2026077446A1 (en) * | 2024-10-12 | 2026-04-16 | Nanjing Legend Biotech Co., Ltd. | Engineered il-15 constructs and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130010121A (ko) * | 2010-03-23 | 2013-01-25 | 인트렉손 코포레이션 | 치료적 단백질을 조건부로 발현하는 벡터,상기 벡터를 포함하는 숙주 세포 및 이의 용도 |
| EP3568474A1 (en) * | 2017-01-10 | 2019-11-20 | Intrexon Corporation | Modulating expression of polypeptides via new gene switch expression systems |
| WO2019014390A1 (en) * | 2017-07-12 | 2019-01-17 | Refuge Biotechnologies, Inc. | METHODS AND SYSTEMS FOR CONDITIONAL REGULATION OF GENE EXPRESSION |
| EP3784256A4 (en) * | 2018-04-27 | 2022-06-29 | Baylor College of Medicine | Car t cells with one or more interleukins |
| CA3102641A1 (en) * | 2018-06-22 | 2019-12-26 | Kite Pharma, Inc. | Chimeric transmembrane proteins and uses thereof |
| AU2019359890B2 (en) * | 2018-10-17 | 2024-10-24 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| EP3907280A4 (en) * | 2018-12-13 | 2022-06-22 | CRAGE medical Co., Limited | ANTI-GPC3 IMMUNE EFFECTOR CELL AND USE THEREOF |
| JP7663513B2 (ja) * | 2019-05-16 | 2025-04-16 | トラスティーズ オブ ボストン ユニバーシティ | 調節された合成遺伝子発現システム |
| WO2021087205A1 (en) * | 2019-11-01 | 2021-05-06 | Senti Biosciences, Inc. | Chimeric receptor sensors |
| JP7792335B2 (ja) * | 2019-12-12 | 2025-12-25 | センティ バイオサイエンシズ インコーポレイテッド | 細胞の調節されたアーマリングのための方法及び組成物 |
| KR20230117107A (ko) * | 2020-11-04 | 2023-08-07 | 센티 바이오사이언시스, 인코포레이티드 | 단백질 페이로드 방출 |
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2022
- 2022-06-16 KR KR1020247001340A patent/KR20240022575A/ko active Pending
- 2022-06-16 JP JP2023577531A patent/JP2024524922A/ja active Pending
- 2022-06-16 TW TW111122516A patent/TW202317753A/zh unknown
- 2022-06-16 WO PCT/US2022/033893 patent/WO2022266396A1/en not_active Ceased
- 2022-06-16 CA CA3221897A patent/CA3221897A1/en active Pending
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- 2022-06-16 EP EP22825875.2A patent/EP4355341A4/en not_active Withdrawn
- 2022-06-16 IL IL309161A patent/IL309161A/en unknown
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2023
- 2023-12-15 US US18/541,684 patent/US20240277766A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240277766A1 (en) | 2024-08-22 |
| KR20240022575A (ko) | 2024-02-20 |
| JP2024524922A (ja) | 2024-07-09 |
| EP4355341A4 (en) | 2025-06-04 |
| IL309161A (en) | 2024-02-01 |
| AU2022294896A1 (en) | 2024-01-25 |
| EP4355341A1 (en) | 2024-04-24 |
| CA3221897A1 (en) | 2022-12-22 |
| WO2022266396A1 (en) | 2022-12-22 |
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