KR20200064129A - 트랜스제닉 선택 방법 및 조성물 - Google Patents

트랜스제닉 선택 방법 및 조성물 Download PDF

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KR20200064129A
KR20200064129A KR1020207013411A KR20207013411A KR20200064129A KR 20200064129 A KR20200064129 A KR 20200064129A KR 1020207013411 A KR1020207013411 A KR 1020207013411A KR 20207013411 A KR20207013411 A KR 20207013411A KR 20200064129 A KR20200064129 A KR 20200064129A
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앨버트 쳉
나다니엘 질레트
메건 두
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Abstract

본 개시내용은 트랜스제닉 세포의 생성 및 선택을 위한 분할 인테인 선택가능한 마커 시스템을 제공한다.

Description

트랜스제닉 선택 방법 및 조성물
<관련 출원>
본 출원은 35 U.S.C. § 119(e) 하에 2018년 1월 11일에 출원된 미국 가출원 번호 62/616,281, 2017년 12월 20일에 출원된 미국 가출원 번호 62/608,478, 2018년 1월 31일에 출원된 미국 가출원 번호 62/624,629, 2017년 10월 12일에 출원된 미국 가출원 번호 62/571,672의 이익을 주장하며, 이들은 그 전문이 본원에 참조로 포함된다.
<서열 목록>
본 출원은 컴퓨터 판독가능한 형태의 서열 목록 (파일명: J022770007WO00-SEQ-HJD; 1.50 MB - ASCII 텍스트 파일; 2018년 10월 3일 생성됨)을 함유하며, 이는 그 전문이 본원에 참조로 포함되고 본 개시내용의 일부를 형성한다.
선택가능한 마커는 원하는 유전자형을 갖는 조작된 세포를 선택하기 위한 트랜스제네시스(transgenesis) 및 게놈 편집에서 광범위하게 채택된다. 항생제 내성 유전자 (항생제 내성 단백질을 코딩함)는 특정 항생제에 대한 내성을 제공하여, 이들 내성 유전자를 발현하는 세포만이 생존하고 증식하도록 한다. 진핵생물 세포에 사용하기 위한 이용가능한 항생제 내성 유전자/항생제는 hygB/히그로마이신, neo/게네티신(Geneticin)®/G418, pac/퓨로마이신, Sh bla/플레오마이신 D1 (제오신(Zeocin)™), 및 bsd/블라스티시딘을 포함한다. 형광 단백질, 예컨대 녹색 형광 단백질(green fluorescent protein)(GFP)은 세포 선택의 또 다른 수단, 예를 들어 형광-활성화 세포 분류법(fluorescent-activated cell sorting)(FACS) 기술 또는 형광 현미경검사를 통한 수단을 제공한다.
<요약>
진핵생물 (예를 들어, 포유동물) 세포에 사용하기 위한 이용가능한 항생제 내성 유전자/항생제의 수가 제한되어 있으므로, 다중 트랜스진(transgene)을 함유하는 세포를 확인하기 위한 선택 방식이 제한된다. 진핵생물 세포에서 항생제 내성을 부여하는 별개의 유전자의 수가 제한되어 있을 뿐만 아니라, 최소 3개의 상이한 항생제 내성 유전자의 동시 사용은 트랜스제닉(transgenic) 세포의 건강에 유해한 영향을 미칠 수 있다. 항생제 선택은 연속적으로 수행될 수 있지만, 이 과정은 시간이 많이 걸린다. 트랜스제닉 세포를 확인하기 위한 선택 방식에 대한 이들 제한은 다중 트랜스진이 도입된 세포를 확인할 필요가 있는 경우 (예를 들어, 트랜스제닉 유기체, 예를 들어 동물 모델, 예컨대 마우스 모델을 생성하기 위해) 문제가 된다.
예를 들어, 2개 이상의 트랜스진 (예를 들어, 이중-트랜스제닉, 삼중-트랜스제닉 등)을 보유하는 세포 및/또는 유기체의 생성 및/또는 확인에 유용한 방법, 조성물 및 키트가 본원에 제공된다. 예를 들어, 조성물 및 키트는 2, 3 또는 4개의 트랜스진을 보유하는 세포 및/또는 유기체의 생성 및/또는 확인을 위해 사용될 수 있다. 이 기술은 적어도 부분적으로, 인테인(intein) 자동-프로세싱 도메인에 의해 개시된 단백질 스플라이싱 메커니즘에 기초하며, 이는 다중 (예를 들어, 2, 3 또는 4개) 별도의 선택가능한 마커 단백질 단편의 다중-트랜스제닉 세포 (이중-트랜스제닉 세포, 삼중-트랜스제닉 세포 또는 사중-트랜스제닉 세포)에서 특이적 연결 (접합)을 용이하게 한다. 다중-트랜스제닉 세포에서 2, 3, 4개 또는 그 이상의 별도의 선택가능한 마커 단백질 단편의 연결은 예를 들어, 항생제 내성 (항생제 내성 단백질)을 부여하거나 적절한 파장의 빛 하에 형광 (형광 단백질)을 낼 수 있는 전장 선택가능한 마커 단백질을 생성한다. 전장 항생제 내성 유전자를 발현하는 세포는 상응하는 항생제의 존재 하에 생존하므로, 다중-트랜스제닉 (예를 들어, 이중-트랜스제닉, 삼중-트랜스제닉 또는 사중-트랜스제닉) 세포로서 선택된다. 마찬가지로, 전장 기능성 형광 단백질을 발현하는 세포는 적절한 파장의 빛 하에 형광을 내므로, 다중-트랜스제닉 (예를 들어, 이중-트랜스제닉, 삼중-트랜스제닉 또는 사중-트랜스제닉) 세포로서 선택된다.
그러므로, 일부 실시양태에서, 본 개시내용은 2종 이상의 벡터를 진핵생물 세포를 포함하는 조성물로 전달하는 것을 포함하는 방법을 제공하며, 여기서 각각의 벡터는 (i) N-말단 인테인 단백질 단편 및/또는 C-말단 인테인 단백질 단편에 연결된 선택가능한 마커 단백질 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 분자를 코딩하는 뉴클레오티드 서열을 포함하며, 여기서 인테인 단백질 단편은 전장 기능 단백질을 형성하도록 프레임에 연결된 경우, 선택가능한 마커 단백질 단편의 연결을 촉매하여 전장 선택가능한 마커 단백질을 생성한다. 예를 들어, 2종의 벡터가 세포의 집단으로 전달된 경우 (예를 들어, 형질감염 조건 하에), 일부 세포는 제1 벡터를 수용할 것이고 (벡터가 세포에 도입됨), 일부 세포는 제2 벡터를 수용할 것이고, 일부 세포는 2종의 벡터 모두를 수용할 것이다. 2종의 벡터 모두를 수용하는 세포만이 전장 기능성 선택가능한 마커 단백질을 발현할 수 있으므로, 이들 세포만이 이중-트랜스제닉 세포로서 선택된다.
일부 실시양태에서, (a) (i) N-말단 인테인 단백질 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 선택가능한 마커 단백질 단편 (예를 들어, 항생제 내성 단백질 단편 또는 형광 단백질 단편)을 코딩하는 뉴클레오티드 서열 및 (ii) 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터, 및 (b) (i) 제2 선택가능한 마커 단백질 단편 (예를 들어, 항생제 내성 단백질 단편 또는 형광 단백질 단편)으로부터 상류에 있는, C-말단 인테인 단백질 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터를 진핵생물 세포를 포함하는 조성물로 전달하는 것을 포함하며, 여기서 N-말단 인테인 단백질 단편 및 C-말단 인테인 단백질 단편은 제2 선택가능한 마커 단백질 단편으로의 제1 선택가능한 마커 단백질 단편의 연결을 촉매하여 전장 선택가능한 마커 단백질을 생성하는 것인 방법이 본원에 제공된다. 2종의 벡터가 세포의 집단으로 전달된 경우 (예를 들어, 형질감염 조건 하에), 일부 세포는 제1 벡터를 수용할 것이고 (벡터가 세포에 도입됨), 일부 세포는 제2 벡터를 수용할 것이고, 일부 세포는 2종의 벡터 모두를 수용할 것이다. 2종의 벡터 모두를 수용하는 세포만이 전장 기능성 선택가능한 마커 단백질을 발현할 수 있으므로, 이들 세포만이 이중-트랜스제닉 세포로서 선택된다.
다른 실시양태에서, 방법은 (a) (i) 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질 (예를 들어, 항생제 내성 단백질 또는 형광 단백질)의 N-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터, (b) (i) 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질의 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, 및 (c) (i) 선택가능한 마커 단백질의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제3 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제3 벡터를 진핵생물 세포로 전달하는 것을 포함하며, 여기서 제1 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 중심 단편으로의 선택가능한 마커 단백질의 N-말단 단편의 연결을 촉매하고, 제2 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 C-말단 단편으로의 선택가능한 마커 단백질의 중심 단편의 연결을 촉매하여 전장 선택가능한 마커 단백질을 생성한다. 3종의 벡터가 세포의 집단으로 전달된 경우 (예를 들어, 형질감염 조건 하에), 일부 세포는 제1 벡터를 수용할 것이고 (벡터가 세포에 도입됨), 일부 세포는 제2 벡터를 수용할 것이고, 일부 세포는 제3 벡터를 수용할 것이고, 일부 세포는 2종의 상이한 벡터를 수용할 것이고, 일부 세포는 3종의 벡터 모두를 수용할 것이다. 3종의 벡터 모두를 수용하는 세포만이 전장 기능성 선택가능한 마커 단백질을 발현할 수 있으므로, 이들 세포만이 삼중-트랜스제닉 세포로서 선택된다.
또 다른 실시양태에서, 방법은 (a) (i) 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질 (예를 들어, 항생제 내성 단백질 또는 형광 단백질)의 N-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터, (b) (i) 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질의 제1 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, (c) (i) 제3 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질의 제2 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제3 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제3 벡터, 및 (d) (i) 선택가능한 마커 단백질의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제3 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제3 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제4 벡터를 진핵생물 세포로 전달하는 것을 포함하며, 여기서 제1 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 제1 중심 단편으로의 선택가능한 마커 단백질의 N-말단 단편의 연결을 촉매하고, 제2 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 제2 중심 단편으로의 선택가능한 마커 단백질의 제1 중심 단편의 연결을 촉매하고, 제3 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 C-말단 단편으로의 선택가능한 마커 단백질의 제2 중심 단편의 연결을 촉매하여 전장 선택가능한 마커 단백질을 생성한다. 4종의 벡터가 세포의 집단으로 전달된 경우 (예를 들어, 형질감염 조건 하에), 일부 세포는 제1 벡터를 수용할 것이고 (벡터가 세포에 도입됨), 일부 세포는 제2 벡터를 수용할 것이고, 일부 세포는 제3 벡터를 수용할 것이고, 일부 세포는 제4 벡터를 수용할 것이고, 일부 세포는 2종의 상이한 벡터를 수용할 것이고, 일부 세포는 3종의 상이한 벡터를 수용할 것이고, 일부 세포는 4종의 벡터 모두를 수용할 것이다. 4종의 벡터 모두를 수용하는 세포만이 전장 기능성 선택가능한 마커 단백질을 발현할 수 있으므로, 이들 세포만이 사중-트랜스제닉 세포로서 선택된다.
명세서의 예들 또는 하나의 섹션에만 개시된 것들을 포함하여 본원에 기재된 임의의 한 실시양태는 명백하게 부인되지 않는 한 임의의 하나 이상의 다른 실시양태와 조합될 수 있는 것으로 의도되는 것으로 이해되어야 한다.
도 1a-1b. 2종의 별도의 트랜스제닉 벡터의 항생제 공동선택을 위한 분할 선택가능한 마커. (도 1a) 선택가능한 마커의 코딩 서열은 N-말단 단편 (MarN) 및 C-말단 단편 (kerC)으로 분할되고, 분할 인테인의 N-말단 단편 (IntN)의 상류 및 분할 인테인의 C-말단 단편 (IntC)의 하류 각각에 별도로 클로닝되며, 2종의 상이한 벡터 각각은 상이한 트랜스진을 보유한다. 이들 벡터는 세포로 전달되어 벡터 중 하나 또는 벡터 중 둘 모두를 함유하는 세포의 하위집단을 수득한다. 2종의 인테인-분할 선택가능한 마커 단편 ("마커트론(markertron)")을 발현하는 두 벡터 모두를 갖는 세포에서만 단백질 트랜스-스플라이싱을 수행하여 전장 선택가능한 마커를 재구성하여 이중 트랜스제닉 세포의 특이적 선택 및 풍부를 허용한다. (도 1b) 항생제 내성 유전자에 대한 인테인과 호환가능한 분할점을 스크리닝하기 위해, 본 발명자들은 시험된 인테인의 유형에 대한 이음부 요건에 따라 잠재적인 분할점을 확인한 후, TagBFP2 또는 mCherry 형광 단백질이 장착된 렌티바이러스 벡터 상의 분할 인테인 스캐폴드(scaffold)에 상응하는 N-말단 및 C-말단 단편을 클로닝하였으며, 이는 선택 효율을 평가하기 위한 시험 트랜스진으로서 작용한다. 이들은 렌티바이러스 형질도입을 통해 세포로 전달된다. 그 후, 세포는 복제 플레이트로 분할되었으며, 하나는 항생제 선택을 거친 반면, 다른 하나는 비-선택 배지에서 유지되었다. 항생제 선택 후, 복제 배양물을 유동 세포계측법에 의해 분석하였다.
도 2a-2f. 인테인-분할 내성 (Intres) 유전자 (선택가능한 마커 유전자라고도 함) 및 플라스미드의 분할점에 대한 세부사항. (도 2a) 히그로마이신 내성 단백질 (서열식별번호(SEQ ID NO): 1)에 대한 분할점. 히그로마이신 내성 단백질의 아미노산 서열에는 본 연구에서 특징화된 분할점을 표지하는 클라우드(cloud)가 제공된다. 표지 내에서, 상단 행은 표 1에 상응하는 플라스미드 번호를 나타낸다. 하단 행은 N-말단 단편에서 마지막 아미노산의 잔기 수, 사용된 인테인의 종, 및 C-말단 단편에서 첫 번째 아미노산의 잔기 수를 나타낸다. "^C"는 시스테인의 삽입을 나타낸다. (도 2b) 퓨로마이신 내성 단백질 (서열식별번호: 2)에 대한 분할점. 퓨로마이신 내성 단백질의 아미노산 서열에는 본 연구에서 특징화된 분할점을 표지하는 클라우드가 제공된다. 표지 내에서, 상단 행은 표 1에 상응하는 플라스미드 번호를 나타낸다. 하단 행은 N-말단 단편에서 마지막 아미노산의 잔기 수, 사용된 인테인의 종, 및 C-말단 단편에서 첫 번째 아미노산의 잔기 수를 나타낸다. "^C"는 시스테인의 삽입을 나타낸다. (도 2c) 네오마이신 내성 단백질 (서열식별번호: 3)에 대한 분할점. 네오마이신 내성 유전자의 아미노산 서열에는 본 연구에서 특징화된 분할점을 표지하는 클라우드가 제공된다. 표지 내에서, 상단 행은 표 1에 상응하는 플라스미드 번호를 나타낸다. 하단 행은 N-말단 단편에서 마지막 아미노산의 잔기 수, 사용된 인테인의 종, 및 C-말단 단편에서 첫 번째 아미노산의 잔기 수를 나타낸다. (도 2d) 블라스티시딘 내성 단백질 (서열식별번호: 4)에 대한 분할점. 블라스티시딘 내성 유전자의 아미노산 서열에는 본 연구에서 특징화된 분할점을 표지하는 클라우드가 제공된다. 표지 내에서, 상단 행은 표 1에 상응하는 플라스미드 번호를 나타낸다. 하단 행은 N-말단 단편에서 마지막 아미노산의 잔기 수, 사용된 인테인의 종, 및 C-말단 단편에서 첫 번째 아미노산의 잔기 수를 나타낸다. (도 2e) 녹색 형광 단백질 (서열식별번호: 5)에 대한 분할점. (도 2f) mScarlet 형광 단백질 (서열식별번호: 6)에 대한 분할점. mScarlet 유전자의 아미노산 서열에는 본 연구에서 특징화된 분할점을 표지하는 클라우드가 제공된다. 표지 내에서, 상단 행은 표 1에 상응하는 플라스미드 번호를 나타낸다. 하단 행은 N-말단 단편에서 마지막 아미노산의 잔기 수, 사용된 인테인의 종, 및 C-말단 단편에서 첫 번째 아미노산의 잔기 수를 나타낸다. "^C"는 시스테인의 삽입을 나타낸다.
도 3. 2-마커트론 히그로마이신 (Hygro) 인테인-분할 내성 (Intres) 유전자. 상단 개략도는 히그로마이신 내성 유전자에 대해 시험된 분할점을 나타낸다. N-말단 단편의 마지막 잔기는 롤리팝(lollipop)의 상단 위에 표시되어 있다. 원형 롤리팝은 NpuDnaE 인테인을 사용하는 분할점을 나타내고, 사각형 롤리팝은 SspDnaB 인테인을 사용하는 분할점을 나타낸다. 줄 그어진 및 음영처리된 롤리팝은 세포에 히그로마이신 내성을 부여하지 못한 분할 쌍을 나타낸다. 아래의 컬럼 플롯은 유동 세포계측법에 의해 분석된 비-선택된 (백색 컬럼) 및 선택된 배양물 (파란색 컬럼) 중 이중-트랜스제닉 세포 (BFP+ mCherry+)의 백분율을 나타낸다.
도 4. 2-마커트론 퓨로마이신 (Puro) Intres 유전자. 상단 개략도는 퓨로마이신 내성 유전자에 대해 시험된 분할점을 나타내는 반면, 하단 컬럼 플롯은 비-선택된 (백색 컬럼) 및 선택된 배양물 (갈색 컬럼) 중 이중 트랜스제닉 세포의 백분율을 나타낸다.
도 5. 2-마커트론 네오마이신 (Neo) 내성 유전자. 상단 개략도는 네오마이신 내성 유전자에 대해 시험된 분할점을 나타내는 반면, 하단 컬럼 플롯은 비-선택된 (백색 컬럼) 및 선택된 배양물 (오렌지색 컬럼) 중 이중 트랜스제닉 세포의 백분율을 나타낸다.
도 6. 2-마커트론 블라스티시딘 (Blast) Intres 유전자. 상단 개략도는 블라스티시딘 내성 유전자에 대해 시험된 분할점을 나타내는 반면, 하단 컬럼 플롯은 비-선택된 (백색 컬럼) 및 선택된 (시안색 컬럼) 배양물 중 이중 트랜스제닉 세포의 백분율을 나타낸다.
도 7a-7c. 2-마커트론 Intres 마커를 갖는 게이트웨이-호환가능한(Gateway-compatible) 렌티바이러스 목적지 벡터. (도 7a) 각각의 분할 Intres 마커에 대한 게이트웨이-호환가능한 렌티바이러스 목적지 벡터 키트는 N-벡터 및 C-벡터로 이루어진다. N-벡터는 바이러스 LTR, CAGGS 프로모터, 게이트웨이 목적지 카세트 AttL, ccdB 유전자, 트랜스진을 보유하는 게이트웨이 공여자 벡터의 LR 클로나제-매개 재조합을 허용하는 클로람페니콜 내성 유전자, 이어서 N-마커트론의 다중시스트론(polycistronic) 발현을 허용하는 내부 리보솜 진입 부위 (IRES)를 함유한다. 유사하게, C-벡터는 C-마커트론을 함유하고, 또 다른 트랜스진의 재조합을 허용한다. (도 7b) TagBFP2 (트랜스진 1로서) 및 mCherry (트랜스진 2로서)는 게이트웨이 재조합에 의해 2-마커트론 Intres 플라스미드로 클로닝되고, 렌티바이러스 형질도입에 의해 세포로 전달되고, 이어서 항생제 선택 및 유동 세포계측법 분석이 수행되었다. 컬럼 플롯은 2-마커트론 히그로마이신 (Hygro, 파란색 컬럼), 퓨로마이신 (Puro, 갈색 컬럼), 및 네오마이신 (Neo, 오렌지색 컬럼) 실험으로부터의 선택된 배양물 대 그의 상응하는 비-선택 배양물 (백색 컬럼) 중 BFP+mCherry+ 이중-양성 세포의 백분율을 나타낸다. (도 7c) 핵을 GFP 형광으로 표지하는 NLS-GFP (트랜스진 1로서) 및 F-액틴을 mScarlet 형광으로 표지하는 lifeAct-mScarlet (트랜스진 2로서)은 전체 비-분할 히그로마이신 내성 유전자를 발현하는 렌티바이러스 벡터 또는 2-마커트론 히그로마이신 Intres 유전자를 갖는 렌티바이러스 벡터로 재조합되고, 이중-표지 세포를 제작하기 위해 U2OS 세포를 형질도입하는데 사용되었다. 대표적인 형광 현미경 이미지는 2주 동안 히그로마이신 선택 후 GFP, mScarlet 및 세포의 병합된 채널을 나타낸다.
도 8a-8c. 2종의 별도의 트랜스제닉 벡터의 형광-매개 공동선택을 위한 분할 mScarlet. (도 8a) 2-마커트론 mScarlet 단백질. 상단 개략도는 mScarlet에 대해 시험된 분할점을 나타낸다. N-말단 단편의 마지막 잔기는 롤리팝의 상단 위에 표시되어 있다. (도 8b) mScarlet에 대한 NpuDnaE 인테인-호환가능한 분할점을 스크리닝하기 위해, 본 발명자들은 NpuDnaE 인테인에 대한 이음부 요건에 따라 잠재적인 분할점을 확인한 후, TagBFP2 또는 EGFP 형광 단백질이 장착된 렌티바이러스 벡터 상의 분할 인테인 스캐폴드에 상응하는 N-말단 및 C-말단 단편을 클로닝하였으며, 이는 선택 효율을 평가하기 위한 시험 트랜스진으로서 작용한다. 이들은 렌티바이러스 형질도입을 통해 세포로 전달된다. 두 렌티바이러스 모두를 갖는 세포는 전장 mScarlet 형광 단백질을 재구성할 뿐만 아니라 TagBFP2 및 EGFP 트랜스진 둘 모두를 발현하기 위해 필수적인 단백질 스플라이싱 기구 및 mScarlet 단편을 함유한다. 세포에 FACS 분석을 수행하였다. 박스형 개략도는 플라스미드 쌍 33+34의 FACS 분석의 예를 나타낸다. P1 집단은 살아있는 단일항 세포에 대한 전방 산란 및 측방 산란을 위해 게이팅되었다. 이들로부터, 세포의 17.8%는 TagBFP 및 EGFP 트랜스진에 대해 이중 양성이다. P1 세포가 mScarlet-양성에 대해 추가로 게이팅된 경우 (mCherry 채널), 세포의 99.4%는 TagBFP 및 EGFP에 대해 이중 양성이다. (도 8c) 아래의 컬럼 플롯은 표시된 분할점 각각의 mScarlet-양성 세포의 백분율을 나타낸다. 위의 컬럼 플롯은 P1 세포 중 TagBFP+ EGFP+ 세포 (백색 컬럼) 및 P1 세포의 mScarlet-양성 서브세트 (적색 컬럼)의 백분율을 나타낸다.
도 9a-9d. 3종 이상의 트랜스제닉 벡터의 공동선택을 위한 다중-분할 선택가능한 마커. (도 9a) 선택가능한 마커는 3개의 단편 (M1, M2 및 M3)으로 분배된다. 제1 마커 단편 (M1)은 제1 분할 인테인의 N-말단 단편 (IN1)의 상류에 융합된다. 제2 마커 단편 (M2)은 제1 분할 인테인의 C-말단 단편 (IC1)의 하류 및 제2 분할 인테인의 N-말단 단편 (IN2)의 상류에 융합된다. 제3 마커 단편 (M3)은 제2 분할 인테인의 C-말단 단편 (IC2)의 하류에 융합된다. 제1 분할 인테인은 M2로의 M1의 연결을 촉매하는 반면, 제2 분할 인테인은 M3으로의 M2의 연결을 촉매하여, 전체 선택가능한 마커를 효과적으로 재구성한다. (도 9b) "인테인 쇄" 메커니즘을 통한 k-분할 선택가능한 마커의 설계. 3-분할 시나리오와 유사하게, 선택가능한 마커는 k 단편으로 분배되고, 개입 분할 인테인에 의해 매개된 단백질 트랜스-스플라이싱을 통해 재구성된다. (도 9c) 2-분할 선택가능한 마커로부터 확인된 분할점은 3-분할 선택가능한 마커를 생성하기 위해 조합하여 사용되었다. 상응하는 단편은 렌티바이러스 벡터로 클로닝되어 벡터 당 3-분할 선택가능한 마커 구조 및 리포터 형광 트랜스진을 생성하였다. 그 후, 세포는 이들 벡터로부터 제조된 바이러스로 형질도입되었으며, 선택 또는 비-선택 배지로 분할되었다. 적절한 선택 기간 후, 배양물은 유동 세포계측법에 의해 분석되었다. (도 9d) 3-마커트론 히그로마이신 (Hygro) Intres. 상단 개략도는 히그로마이신 내성 유전자에 대해 시험된 분할점을 나타내며, N-말단 단편의 마지막 아미노산의 잔기 수는 NpuDnaE 및 SspDnaB 인테인을 각각 나타내는 원형 또는 사각형 롤리팝 위에 표시된다. 6종의 3-마커트론 히그로마이신 Intres를 시험하였으며, 각각은 각각의 경우에 사용된 2개의 분할점을 나타내는 원형 또는 사각형으로 넘버링된 라인으로 표시된다. 아래의 컬럼 플롯은 하기 숫자로 표시된 3-마커트론 히그로마이신 Intres에 대한 비-선택 (백색 컬럼) 및 선택 (파란색 컬럼) 배양물로부터의 삼중 트랜스제닉 (BFP+ GFP+ mCherry+) 세포의 백분율을 나타낸다.
도 10a-10c. 3-마커트론 히그로마이신 Intres 유전자를 갖는 게이트웨이-호환가능한 렌티바이러스 목적지 벡터. (도 10a) 바이러스 LTR, CAGGS 프로모터, 게이트웨이 목적지 카세트 AttL, ccdB 유전자, 트랜스진을 보유하는 게이트웨이 공여자 벡터의 LR 클로나제-매개 재조합을 허용하는 클로람페니콜 내성 유전자, 이어서 3종의 3-분할 히그로마이신 마커트론 각각의 다중시스트론 발현을 허용하는 내부 리보솜 진입 부위 (IRES)를 갖는 게이트웨이-호환가능한 렌티바이러스 목적지 벡터. (도 10b) TagBFP2 (트랜스진 1로서) 및 EGFP (트랜스진 2로서) 및 mCherry (트랜스진 3으로서)는 게이트웨이 재조합에 의해 3-분할 Intres 플라스미드로 클로닝되고, 렌티바이러스 형질도입에 의해 세포로 전달되고, 이어서 항생제 선택 및 유동 세포계측법 분석이 수행되었다. (도 10c) 컬럼 플롯은 선택된 히그로마이신 (파란색 컬럼) 대 그의 상응하는 비-선택 배양물 (백색 컬럼) 중 BFP+GFP+mCherry+ 삼중-양성 세포의 백분율을 나타낸다.
도 11. 4-분할 Hygro intres. (a) 4종의 상이한 플라스미드에 의해 발현된 4-분할 hygro intres의 마커트론. 플라스미드 115는 히그로마이신 내성 유전자의 아미노산 1~89 [Hygro(1-89)]를 NpuDnaE(N) 및 류신 지퍼 A 모티프 (LZA)로 융합함으로써 생성된 마커트론을 발현한다. 플라스미드 116은 N-말단으로부터 C-말단으로 류신 지퍼 B 모티프 (LZB)-NpuDnaGEP(C), Hygro(90-200) 및 SspDnaB(N)를 융합함으로써 생성된 마커트론을 발현한다. 플라스미드 117은 N-말단으로부터 C-말단으로 SspDnaB(C), Hygro(201-240), NpuDnaE(N)-LZA를 융합함으로써 생성된 마커트론을 발현한다. 플라스미드 118은 LZB-NpuDnaGEP(C)를 Hygro(241-341)로 융합함으로써 생성된 마커트론을 발현한다.
도 12a-12e. Intres 마커는 CRISPR/Cas-매개 녹-인(knock-in) 실험으로부터 이대립유전자 표적화된 세포의 풍부를 허용한다. AAVS1 안전한 하버(harbor) 유전자좌에 대한 상동성 아암을 함유하는 표적화 구축물 쌍은 전장 (FL) 비-분할 또는 분할 Intres 마커를 함유하도록 설계되었고, 항생제 선택을 통해 이대립유전자 표적화된 세포를 풍부하게 하는 능력에 대해 시험되었다. (도 12a) 플라스미드 107 및 108은 AAVS1 유전자좌에서 내인성 PPP1R12C 프로모터에 의해 구동되는 FL 네오마이신 (Neo) 내성 유전자, EF1a 프로모터에 의해 구동되는 FL 히그로마이신 (Hygro) 유전자 및 rtTA Dox-반응성 트랜스활성인자, 뿐만 아니라 dox-유도성 TetO 프로모터로부터 발현된 FL 블라스티시딘 (Blast) 뿐만 아니라 EGFP (플라스미드 107) 및 mScarlet (플라스미드 108)을 함유한다. 플라스미드 106은 Cas9 및 AAVS 유전자좌를 표적화하는 sgRNA를 함유한다. 2A: 자기-절단 2A 펩티드. 플라스미드 106, 107 및 108은 HEK293T 세포로 공동-형질감염되고, 분할되고, dox-함유 히그로마이신, 블라스티시딘 또는 비-선택 배지에서 2주 동안 계대배양되고, 이대립유전자 표적화의 효율을 분석하기 위해 유동 세포계측법에 의해 분석하였다. (도 12b) 플라스미드 109 및 110은 플라스미드 107 및 108과 유사한 구조를 함유하나, FL Blast 대신에 분할 Blast Intres를 갖는다. (도 12c) 플라스미드 111 및 112는 EF1a-구동된 FL Blast 및 TetO-구동된 FL Hygro, 니트로리덕타제 (NTR), 2A 펩티드에 의해 분리된 형광 단백질 (EGFP 또는 mCherry)을 함유한다. (도 12d) 플라스미드 113 및 114는 플라스미드 111 및 112와 유사하나, FL Hygro 대신에 Hygro Intres를 갖는다. (도 12e) dox-함유 비-선택 배지 (선택: 없음), 블라스티시딘 선택 배지 (Blast) 및 히그로마이신 선택 배지 (Hygro)에서 배양 후 2주에, 플라스미드 106 (Cas9+AAVS-sgRNA)으로 형질감염된 세포 및 표시된 표적화 구축물 쌍의 유동 세포계측법 분석.
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일부 측면에서, 하나 초과의 트랜스진 (또는 다른 유전적 요소)이 도입된 트랜스제닉 (예를 들어, 다중-트랜스제닉, 예컨대 이중 트랜스제닉 또는 삼중 트랜스제닉) 유기체를 생성하는 방법이 본원에 제공된다. 도 1a에 나타낸 바와 같이, 본 개시내용의 예시적인 방법은 (a) N-말단 인테인 단백질 단편으로부터 상류에 있는 제1 선택가능한 마커 단백질 단편을 코딩하는 벡터 및 관심있는 제1 트랜스진, 및 (b) 제2 선택가능한 마커 단백질 단편으로부터 상류에 있는 C-말단 인테인 단백질 단편을 코딩하는 또 다른 벡터 및 관심있는 제2 (예를 들어, 상이한) 트랜스진을 세포의 집단으로 전달하는 것을 포함한다. 집단의 일부 세포는 단일 벡터 (인테인의 단편, 선택가능한 마커 단백질의 단편, 및 단일 트랜스진만을 보유함)를 수용할 것이나, 집단의 다른 세포는 2종의 벡터 모두 (및 그러므로 인테인 단편 둘 모두, 선택가능한 마커 단백질 단편 둘 모두, 및 관심있는 트랜스진 둘 모두)를 수용할 것이다. 2종의 벡터 모두를 수용하는 세포에서, 번역 후, 인테인 단백질 단편은 인테인 구조로 자발적으로 및 비-공유결합으로 어셈블리하여 (협동적으로 폴딩하여), 제2 선택가능한 마커 단백질 단편으로의 제1 선택가능한 마커 단백질 단편의 연결을 촉매하여, 전장 선택가능한 마커 단백질을 생성하며, 이는 상기 이중 트랜스제닉 세포의 특이적 선택을 가능하게 한다. 예를 들어, 선택가능한 마커 단백질이 항생제 내성 단백질인 경우, 전장 (기능성) 항생제 내성 단백질을 발현하는 이중-트랜스제닉 세포만이 특정 항생제의 존재 하에 선택에서 생존할 것이다. 또 다른 예로서, 선택가능한 마커 단백질이 형광 단백질인 경우, 전장 (기능성) 형광 단백질을 발현하는 이중-트랜스제닉 세포만이 신호-방출 세포만이 선택되도록 검출가능한 신호를 방출할 것이다.
본 개시내용의 또 다른 예시적인 방법은 (a) (i) 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 항생제 내성 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터, (b) (i) 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 항생제 내성 단백질의 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, 및 (c) (i) 항생제 내성 단백질의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제3 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제3 벡터를 세포의 집단으로 전달하는 것을 포함한다. 집단의 일부 세포는 단일 벡터 (인테인의 단편, 선택가능한 마커 단백질의 단편, 및 단일 트랜스진만을 보유함)를 수용할 것이나, 집단의 다른 세포는 2종의 벡터 또는 3종의 벡터 모두 (및 그러므로 인테인 단편 모두, 선택가능한 마커 단백질 단편 모두, 및 관심있는 트랜스진 모두)를 수용할 것이다. 3종의 벡터 모두를 수용하는 세포에서, 번역 후, 인테인 단백질 단편은 인테인 구조로 자발적으로 및 비-공유결합으로 어셈블리하여 (협동적으로 폴딩하여), 선택가능한 마커 단백질의 N-말단 단편의 중심 단편으로의 연결, 및 중심 단편의 선택가능한 마커 단백질의 C-말단 단편으로의 연결을 촉매하여, 전장 선택가능한 마커 단백질을 생성하며, 이는 상기 삼중-트랜스제닉 세포의 특이적 선택을 가능하게 한다. 예를 들어, 선택가능한 마커 단백질이 항생제 내성 단백질인 경우, 전장 (기능성) 항생제 내성 단백질을 발현하는 삼중-트랜스제닉 세포만이 특정 항생제의 존재 하에 선택에서 생존할 것이다. 또 다른 예로서, 선택가능한 마커 단백질이 형광 단백질인 경우, 전장 (기능성) 형광 단백질을 발현하는 삼중-트랜스제닉 세포만이 신호-방출 세포만이 선택되도록 검출가능한 신호를 방출할 것이다.
인테인
인테인 (개입 단백질)은 단백질 스플라이싱이라고 공지된 고유한 자동-프로세싱 사건을 수행하며, 여기서 이는 2개의 펩티드 결합의 절단을 통해 더 큰 전구체 폴리펩티드로부터 그 자신을 절제하고, 이 과정에서, 새로운 펩티드 결합의 형성을 통해 플랭킹(flanking) 익스테인(extein) (외부 단백질) 서열을 라이게이션한다. 이 재배열은 인테인 유전자가 다른 단백질-코딩 유전자 내에 프레임에 내장된 것으로 발견되기 때문에 번역후 (또는 가능하게는 번역과 공동으로) 발생한다. 더욱이, 인테인-매개 단백질 스플라이싱은 자발적이며; 외부 인자 또는 에너지 공급원이 필요하지 않으며, 오직 인테인 도메인의 폴딩만이 필요하다. 사실상, 전구체 단백질은 3개의 세그먼트, 즉 N-익스테인 (단백질의 N-말단 부분), 이어서 인테인, 이어서 C-익스테인 (단백질의 C-말단 부분)을 함유한다. 스플라이싱 후, 생성된 단백질은 C-익스테인에 연결된 N-익스테인을 함유한다.
두 유형의 인테인이 있다: 시스-스플라이싱 인테인은 숙주 단백질에 내장된 단일 폴리펩티드인 반면, 트랜스-스플라이싱 인테인 (분할 인테인이라고 함)은 인테인 조각 및 그의 단백질 카고(cargo)가 회합한 후 단백질 스플라이싱을 매개하는 별도의 폴리펩티드이다 (예를 들어, 문헌 [Paulus, H Annu Rev Biochem 69:447-496 (2000)]; 및 [Saleh L, Perler FB Chem Rec 6:183-193 (2006)] 참조). 분할 인테인은 인테인이 적절히 어셈블리되고 폴딩되는 것을 필요로 하는 일련의 화학적 재배열을 촉매한다. 스플라이싱에서 제1 단계는 N-익스테인 폴리펩티드가 인테인의 제1 잔기의 측쇄로 전이되는 N-S 아실 이동을 수반한다. 그 후, 이는 이 아실 단위가 C-익스테인의 제1 잔기 (이는 세린, 트레오닌 또는 시스테인임)로 전이되어 분지된 중간체를 형성하는 트랜스-(티오)에스테르화 반응으로 이어진다. 프로세스의 끝에서 두 번째 단계에서, 이 분지된 중간체는 인테인의 C-말단 아스파라긴 잔기를 수반하는 아미드 교환 반응에 의해 인테인으로부터 절단된다. 그 후, 이는 두 익스테인 사이에 정상적인 펩티드 결합을 생성하도록 S-N 아실 전이를 수반하는 프로세스의 최종 단계를 설정한다 (Lockless, SW, Muir, TW PNAS 106(27): 10999-11004 (2009)).
현재까지, 인테인이 내장된 숙주 유전자의 유형 뿐만 아니라 그 숙주 유전자 내에 통합점에 의해 구별되는 적어도 70종의 상이한 인테인 대립유전자가 있다 (Perler, FB Nucleic Acids Res. 30: 383-384 (2002); Pietrokovski, S Trends Genet. 17: 465-472 (2001)). 확인된 인테인 유전자의 작은 분율 (5% 미만)이 분할 인테인을 코딩한다. 더 흔한 인접 인테인과 달리, 분할 인테인은 각각 하나의 익스테인에 융합된 2개의 별도의 폴리펩티드, N-인테인 및 C-인테인으로서 전사되고 번역된다. 번역시, 인테인 단편은 정준적 인테인 구조로 자발적으로 및 비-공유결합으로 어셈블리하여 (협동적으로 폴딩하여), 단백질 스플라이싱을 트랜스로 수행한다. 시아노박테리아 시네코시스티스(Synechocystis) 종 PCC6803 (Ssp) 및 노스톡 푼크티포르메(Nostoc punctiforme) PCC73102 (Npu)로부터 특징화된 첫 번째 2개의 분할 인테인은 DNA 폴리머라제 III (DnaE)의 α 서브유닛에 삽입된 것으로 자연적으로 발견되는 오르토로그(ortholog)이다. Npu는 단백질 트랜스-스플라이싱의 현저하게 빠른 속도로 인해 특히 주목할 만하다 (t1/2 = 30℃에서 50 s). 이 반감기는 Ssp의 반감기보다 유의하게 짧다 (t1/2 = 30℃에서 80 min) (Shah, NH et al. J. Am. Chem. Soc. 135: 5839 (2013)).
여기서, 분할 인테인은 선택가능한 마커 단백질, 예컨대 항생제 내성 단백질 또는 형광 단백질의 2개의 단편 (예를 들어, N-말단 단편 및 C-말단 단편)의 연결을 촉매하여 기능성 전장 단백질을 생성하는데 사용된다 (예를 들어, 도 1a 및 1b).
분할 인테인은 자연 분할 인테인 또는 조작된 분할 인테인일 수 있다. 자연 분할 인테인은 다양한 상이한 유기체에서 자연적으로 발생한다. 분할 인테인의 가장 큰 공지된 패밀리는 적어도 20종의 시아노박테리아 종의 DnaE 유전자 내에서 발견된다 (Caspi J, et al. Mol. Microbiol. 50: 1569-1577 (2003)). 그러므로, 본 개시내용의 일부 실시양태에서, 자연 분할 인테인은 DnaE 인테인으로부터 선택된다. DnaE 인테인의 비제한적인 예는 시네코시스티스 sp. DnaE (SspDnaE) 인테인 및 노스톡 푼크티포르메 (NpuDnaE) 인테인을 포함한다.
일부 실시양태에서, 분할 인테인은 조작된 분할 인테인이다. 조작된 분할 인테인은 인접 인테인으로부터 생성될 수 있거나 (여기서, 인접 인테인은 인공적으로 분할됨), 예를 들어, 효율적인 단백질 정제, 라이게이션, 변형 및 고리화를 촉진하는 변형된 자연 분할 인테인일 수 있다 (예를 들어, NpuGEP 및 CfaGEP, 문헌 [AJ PNAS 114(32): 8538-8543 (2017)]에 기재된 바와 같음). 분할 인테인을 조작하는 방법은 예를 들어, 본원에 참조로 포함된 문헌 [Aranko, AS et al. Protein Eng Des Sel. 27(8): 263-271 (2014)]에 기재되어 있다. 일부 실시양태에서, 조작된 분할 인테인은 DnaB 인테인으로부터 조작된다 (Wu, H, et al. Biochim Biophys Acta 1387(1-2): 422-432 (1998)). 예를 들어, 조작된 분할 인테인은 SspDnaB S1 인테인일 수 있다. 일부 실시양태에서, 조작된 분할 인테인은 GyrB 인테인으로부터 조작된다. 예를 들어, 조작된 분할 인테인은 SspGyrB S11 인테인일 수 있다.
삼중-트랜스제닉이 생성되는 일부 실시양태에서, 예를 들어, 제1 인테인은 제2 인테인과 동일할 수 있다 (예를 들어, 둘 모두 DnaE 인테인). 다른 실시양태에서, 2종의 상이한 인테인이 사용될 수 있다 (예를 들어, DnaE 인테인 및 DnaB 인테인). 일부 실시양태에서, 제1 인테인은 NpuDnaE 인테인이고, 제2 인테인은 NpuDnaE 인테인이다.
선택가능한 마커 단백질
본 개시내용의 트랜스제닉 (예를 들어, 이중 및/또는 삼중 트랜스제닉) 세포는 전장 선택가능한 마커 단백질의 그의 발현에 기초하여 선택된다. 선택가능한 마커 단백질은 인공 선택에 적합한 형질을 일반적으로 부여한다. 선택가능한 마커 단백질의 예는 항생제 내성 단백질 및 형광 단백질을 포함한다.
항생제 내성 유전자는 특정 항생제 또는 항생제의 부류에 대한 내성을 부여하는 단백질을 코딩하는 유전자이다. 진핵생물 세포에서 사용하기 위한 항생제 내성 유전자의 비제한적인 예는 히그로마이신, G418, 퓨로마이신, 플레오마이신 D1 또는 블라스티시딘에 대한 내성을 부여하는 단백질을 코딩하는 유전자를 포함한다. 원핵생물 세포에서 사용하기 위한 항생제 내성 유전자의 비제한적인 예는 히그로마이신, G418, 퓨로마이신, 플레오마이신 D1, 블라스티시딘, 카나마이신, 스펙티노마이신, 스트렙토마이신, 암피실린, 카르베니실린, 블레오마이신, 에리트로마이신, 폴리믹신 D, 테트라사이클린 및 클로람페니콜에 대한 내성을 부여하는 단백질을 코딩하는 유전자를 포함한다.
히그로마이신 B는 스트렙토미세스 히그로스코피쿠스(Streptomyces hygroscopicus) 박테리아에 의해 생성되는 항생제이다. 이는 단백질 합성을 억제함으로써 박테리아, 진균 및 고등 진핵생물 세포를 사멸시키는 아미노글리코시드이다. 본래 에스케리치아 콜라이(Escherichia coli)로부터 유래된 hpt 유전자 (hph 또는 aphIV 유전자라고도 함)에 의해 코딩되는 히그로마이신 포스포트랜스퍼라제 (HPT)는 아미노시클리톨 항생제 히그로마이신 B를 해독한다. 그러므로, 일부 실시양태에서, 본 개시내용의 선택가능한 마커 유전자는 hpt 유전자이다.
G418 (게네티신®)은 겐타마이신 B1과 구조가 유사한 아미노글리코시드 항생제이다. 이는 미크로모노스포라 로도란게아(Micromonospora rhodorangea)에 의해 생성된다. G418은 원핵생물 및 진핵생물 세포 둘 모두에서 신장 단계를 억제함으로써 폴리펩티드 합성을 차단한다. G418에 대한 내성은 아미노글리코시드 3'-포스포트랜스퍼라제, APT 3' II를 코딩하는 Tn5로부터의 neo 유전자에 의해 부여된다. G418은 네오마이신 술페이트의 유사체이며, 네오마이신과 유사한 메커니즘을 갖는다. 그러므로, 일부 실시양태에서, 본 개시내용의 선택가능한 마커 유전자는 neo 유전자이다.
퓨로마이신은 스트렙토미세스 알보니게르(Streptomyces alboniger)로부터 유래된 아미노뉴클레오시드 항생제이며, 리보솜에서 일어나는 번역 동안 조기 쇄 종결을 야기한다. 퓨로마이신은 원핵생물 또는 진핵생물에 대해 선택적이다. 퓨로마이신에 대한 내성은 퓨로마이신 N-아세틸-트랜스퍼라제 (pac) 유전자의 발현을 통해 부여된다. 그러므로, 일부 실시양태에서, 본 개시내용의 선택가능한 마커 유전자는 pac 유전자이다.
플레오마이신 D1 (예를 들어, 제오신®)은 글리코펩티드 항생제이며, 항생제의 블레오마이신 패밀리에 속하는 스트렙토미세스 베르티실루스(Streptomyces verticillus)로부터의 플레오마이신 중 하나이다. 이는 대부분의 박테리아, 사상 진균, 효모, 식물 및 동물 세포에 대해 효과적인 광범위-스펙트럼 항생제이다. 이는 DNA에 삽입함으로써 세포 사멸을 야기하고 DNA의 이중 가닥 파단을 유도한다. 플레오마이신 D1에 대한 내성은 스트렙토알로테이쿠스 힌두스타누스(Streptoalloteichus hindustanus)로부터 처음 단리된 Sh ble 유전자의 생성물에 의해 부여된다. 그러므로, 일부 실시양태에서, 본 개시내용의 선택가능한 마커 유전자는 Sh ble 유전자이다.
블라스티시딘 S는 스트렙토미세스 그리세오크로모게네스(Streptomyces griseochromogenes)에 의해 생성되는 항생제이다. 블라스티시딘은 번역의 종결 단계 및 리보솜에 의한 펩티드 결합 형성 (더 적은 정도로)을 억제함으로써 진핵생물 및 원핵생물 세포 둘 모두의 성장을 방지한다. 블라스티시딘에 대한 내성은 적어도 3종의 상이한 유전자에 의해 부여된다: 스트렙토베르티실룸(Streptoverticillum) spp.로부터의 bls (아세틸트랜스퍼라제); 바실러스 세레우스(Bacillus cereus)로부터의 bsr (블라스티시딘-S 데아미나제) (다른 bsr 유전자도 공지되어 있음); 및 아스페르길루스 테레우스(Aspergillus terreus)로부터의 bsd (또 다른 데아미나제). 그러므로, 일부 실시양태에서, 본 개시내용의 선택가능한 마커 유전자는 bls 유전자, bsr 유전자 또는 bsd 유전자이다.
본원에 제공된 바와 같이 사용될 수 있는 형광 단백질의 비제한적인 예는 TagCFP, mTagCFP2, Czurite, ECFP2, mKalama1, Sirius, Sapphire, T-Sapphire, ECFP, Cerulean, SCFP3C, mTurquoise, mTurquoise2, 모노머 Midoriishi-Cyan, TagCFP, mTFP1, EGFP, Emerald, Superfolder GFP, 모노머 Czami Green, TagGFP2, mUKG, mWasabi, Clover, mNeonGreen, EYFP, Citrine, Venus, SYFP2, TagYFP, 모노머 Kusabira-Orange, mKOκ, mKO2, mOrange, mOrange2, mRaspberry, mCherry, mStrawberry, mScarlet, mTangerine, tdTomato, TagRFP, TagRFP-T, mCpple, mRuby, mRuby2, mPlum, HcRed-Tandem, mKate2, mNeptune, NirFP, TagRFP657, IFP1.4 및 iRFP를 포함한다.
일부 실시양태에서, 전장 선택가능한 마커 유전자는 동일한 세포에서 2개의 선택가능한 마커 유전자 단편을 연결함으로써 생성된다. 일부 실시양태에서, 임의의 전장 단백질에 관하여, 단편 중 하나는 N-말단 단편 (N-익스테인)인 반면, 다른 단편은 C-말단 단편 (C-익스테인)이다. 그러므로, 일부 실시양태에서, 제1 항생제 내성 단백질 단편은 N-말단 항생제 내성 단백질 단편이고, 제2 항생제 내성 단백질 단편은 C-말단 항생제 내성 단백질 단편이다. 다른 실시양태에서, 제1 형광 단백질 단편은 N-말단 형광 단백질 단편이고, 제2 형광 단백질 단편은 C-말단 형광 단백질 단편이다.
다른 실시양태에서, 전장 선택가능한 마커 유전자는 동일한 세포에서 3개 이상의 선택가능한 마커 유전자 단편을 연결함으로써 생성된다. 일부 실시양태에서, 임의의 전장 단백질에 관하여, 단편 중 하나는 N-말단 단편이고, 단편 중 하나 이상 (예를 들어, 1, 2 또는 3개)은 중심 단편이고, 단편 중 하나는 C-말단 단편이다.
N-말단 단편은 전장 단백질의 유리 아민 기 (-NH2)를 포함하는 임의의 단백질 단편일 수 있다. C-말단 단편은 유리 카르복실 기 (-COOH)를 포함하는 임의의 단백질 단편일 수 있다. 중심 단편은 전장 단백질의 N-말단 단편 및 C-말단 단편 사이에 위치된 임의의 단백질 단편일 수 있다.
예를 들어, 유전자 코딩 히그로마이신 (341-아미노산 단백질)의 아미노산 1-89는 N-말단 단백질 단편으로서 지칭될 수 있는 반면, 아미노산 90-341은 C-말단 단편으로서 지칭될 수 있다. 유사하게, 도 5에 관하여, 히그로마이신을 코딩하는 유전자의 아미노산 1-200은 N-말단 단백질 단편으로서 지칭될 수 있는 반면, 아미노산 201-341은 C-말단 단편으로서 지칭될 수 있다. 도 6은 아미노산 1-53, 1-240, 또는 1-292가 각각의 C-말단 단편으로서 아미노산 54-341, 241-341, 또는 293-341을 함유하는 전장 히그로마이신의 N-말단 단백질 단편으로 간주되는 추가 예를 나타낸다.
또 다른 예로서, 유전자 코딩 히그로마이신 (341-아미노산 단백질)의 아미노산 1-52는 N-말단 단백질 단편으로서 지칭될 수 있고, 아미노산 53-89는 중심 단백질 단편으로서 지칭될 수 있고, 아미노산 90-341은 C-말단 단편으로서 지칭될 수 있다. 유사하게, 히그로마이신을 코딩하는 유전자의 아미노산 1-89는 N-말단 단백질 단편으로서 지칭될 수 있고, 아미노산 90-240은 중심 단편으로서 지칭될 수 있고, 아미노산 241-341은 C-말단 단편으로서 지칭될 수 있다.
관심있는 트랜스진 및 다른 분자
일부 실시양태에서, 본 개시내용의 방법 및 조성물은 다중-트랜스제닉 (예를 들어, 이중 및/또는 삼중 트랜스제닉) 세포 및/또는 유기체를 생성하는데 사용된다. 그러므로, 일부 실시양태에서, 방법은 제1 분자 (관심있는 제1 분자)를 코딩하는 하나의 벡터 및 제2 분자 (관심있는 제2 분자)를 코딩하는 또 다른 벡터를 사용한다. 일부 실시양태에서, 방법은 관심있는 제3 분자를 코딩하는 또 다른 벡터를 사용한다. 추가 벡터 (예를 들어, 선택가능한 마커 단백질의 추가 중심 단편을 코딩함)는 관심있는 추가 분자를 코딩할 수 있다. 관심있는 분자는 예를 들어, 폴리펩티드 (예를 들어, 단백질 및 펩티드) 또는 폴리뉴클레오티드 (예를 들어, 핵산, 예컨대 DNA 또는 RNA)일 수 있다.
일부 실시양태에서, 제1 분자 (예를 들어, 제1 벡터 상에 위치됨)는 단백질이다. 일부 실시양태에서, 제2 분자 (예를 들어, 제2 벡터 상에 위치됨)는 단백질이다. 일부 실시양태에서, 제3 분자 (예를 들어, 제3 벡터 상에 위치됨)는 단백질이다. 관심있는 단백질의 예는 효소, 시토카인, 전사 인자, 호르몬, 성장 인자, 혈액 인자, 항원 및 항체를 포함하나, 이에 제한되지는 않는다.
일부 실시양태에서, 제1 분자는 펩티드이다. 일부 실시양태에서, 제2 분자는 펩티드이다. 일부 실시양태에서, 제3 분자는 펩티드이다.
일부 실시양태에서, 제1 분자는 메신저 RNA (mRNA)이다. 일부 실시양태에서, 제2 분자는 mRNA이다. 일부 실시양태에서, 제3 분자는 mRNA이다. 일부 실시양태에서, mRNA는 백신 또는 다른 항원성 분자를 코딩한다.
일부 실시양태에서, 제1 분자는 비-코딩 RNA (단백질을 코딩하지 않는 RNA)이다. 일부 실시양태에서, 제2 분자는 비-코딩 RNA이다. 일부 실시양태에서, 제3 분자는 비-코딩 RNA이다. 비-코딩 RNA의 예는 RNA 간섭 분자, 예컨대 마이크로RNA (miRNA), 안티센스 RNA, 짧은-간섭 RNA (siRNA) 또는 짧은-헤어핀 RNA (shRNA)를 포함하나, 이에 제한되지는 않는다.
벡터
본 개시내용의 방법은 적어도 2종 또는 적어도 3종의 상이한 벡터의 사용을 포함한다. 벡터는 외인성 (외래) 유전 물질을 세포로 운반하는 비히클로서 사용될 수 있는 임의의 핵산이다. 일부 실시양태에서, 벡터는 삽입물 (예를 들어, 트랜스진) 및 벡터의 백본으로서 작용하는 더 큰 서열을 포함하는 DNA 서열이다. 벡터의 비제한적인 예는 플라스미드, 바이러스/바이러스 벡터, 코스미드, 및 인공 염색체를 포함하며, 이들 중 임의의 것이 본원에 제공된 바와 같이 사용될 수 있다. 일부 실시양태에서, 벡터는 바이러스 벡터, 예컨대 바이러스 입자이다. 일부 실시양태에서, 벡터는 RNA-기반 벡터, 예컨대 자기-복제 RNA 벡터이다. 일부 실시양태에서, 제1 벡터는 플라스미드이고/거나, 제2 벡터는 플라스미드이고/거나, 제3 벡터는 플라스미드이다. 본원에 제공된 바와 같은 벡터는 인테인의 단편 및 선택가능한 마커 단백질의 단편을 코딩하는 핵산에 작동가능하게 연결된 프로모터를 포함한다. 일부 실시양태에서, 벡터는 또한 관심있는 분자를 코딩하는 핵산, 예컨대 트랜스진에 작동가능하게 연결된 프로모터를 포함한다.
일부 실시양태에서, 하나의 벡터 (예를 들어, 제1 벡터)는 N-말단 인테인 단백질 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는 제1 선택가능한 마커 단백질 단편을 코딩하는 뉴클레오티드 서열을 포함하는 반면, 다른 하나의 벡터 (예를 들어, 제2 벡터)는 제2 항생제 내성 단백질 단편으로부터 상류에 있는 C-말단 인테인 단백질 단편을 코딩하는 뉴클레오티드 서열을 포함한다 (예를 들어, 도 1a 참조). 이 구성은 제1 선택가능한 마커 단백질 단편을 코딩하는 뉴클레오티드 서열로부터 하류에 있는 N-말단 인테인 단백질 단편을 코딩하는 뉴클레오티드 서열을 포함하는 하나의 벡터 (예를 들어, 제1 벡터), 및 C-말단 인테인 단백질 단편을 코딩하는 뉴클레오티드 서열로부터 하류에 있는 제2 항생제 내성 단백질 단편을 포함하는 다른 하나의 벡터 (예를 들어, 제2 벡터)와 동등하다. 용어 "상류" 및 "하류"는 핵산에서의 상대 위치를 지칭한다. 각각의 핵산은 데옥시리보스 (또는 리보스) 고리 상의 탄소 위치로 명명되는 5' 말단 및 3' 말단을 갖는다. 예를 들어, 이중-가닥 DNA를 고려할 때, 상류는 코딩 가닥의 5' 말단을 향하고, 하류는 3' 말단을 향한다.
일부 실시양태에서, (a) 제1 벡터는 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 항생제 내성 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하고, (b) 제2 벡터는 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 항생제 내성 단백질의 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하고, (c) 제3 벡터는 항생제 내성 단백질의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열을 포함한다. 이 구성은 a) 항생제 내성 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 하류에 있는, 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터, (b) 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 하류에 있는, 항생제 내성 단백질의 중심 단편을 코딩하는 뉴클레오티드 서열로부터 하류에 있는, 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, 및 (c) 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 하류에 있는, 항생제 내성 단백질의 C-말단 단편을 포함하는 제3 벡터와 동등하다.
세포
본 개시내용의 방법은 본원에 기재된 벡터 (예를 들어, 제1 및 제2 벡터)를 숙주 세포로 도입함으로써 트랜스제닉 세포 및 유기체를 생성하는데 사용될 수 있다. 벡터가 도입된 세포는 진핵생물 또는 원핵생물일 수 있다. 일부 실시양태에서, 세포는 진핵생물이다. 본원에 제공된 바와 같이 사용하기 위한 진핵생물 세포의 예는 포유동물 세포, 식물 세포 (예를 들어, 작물 세포), 곤충 세포 (예를 들어, 드로소필라(Drosophila)) 및 진균 세포 (예를 들어, 사카로미세스(Saccharomyces))를 포함한다. 포유동물 세포는 예를 들어, 인간 세포 (줄기 세포 또는 확립된 세포주로부터의 세포), 영장류 세포, 말 세포, 소 세포, 돼지 세포, 개 세포, 고양이 세포, 또는 설치류 세포 (예를 들어, 마우스 또는 래트)일 수 있다. 본원에 제공된 바와 같이 사용하기 위한 포유동물 세포의 예는 차이니즈 햄스터 난소 (CHO) 세포, 인간 배아 신장 (HEK) 293 세포, HeLa 세포 및 NS0 세포를 포함하나, 이에 제한되지는 않는다. 일부 실시양태에서, 세포는 원핵생물이다. 본원에 제공된 바와 같이 사용하기 위한 원핵생물 세포의 예는 박테리아 세포를 포함한다. 박테리아 세포는 예를 들어, 에스케리치아(Escherichia) spp. (예를 들어, 에스케리치아 콜라이), 스트렙토코쿠스(Streptococcus) spp. (예를 들어, 스트렙토코쿠스 피오게네스(Streptococcus pyogenes), 스트렙토코쿠스 비리단스(Streptococcus viridans), 스트렙토코쿠스 뉴모니아에(Streptococcus pneumoniae)), 네이쎄리아(Neisseria) spp. (예를 들어, 네이쎄리아 기비로에아(Neisseria gibirrhoea), 네이쎄리아 메닌기티디스(Neisseria meningitidis)), 코리네박테리움(Corynebacterium) spp. (예를 들어, 코리네박테리움 디프테리아에(Corynebacterium diphtheriae)), 바실리스(Bacillis) spp. (예를 들어, 바실리스 안트라시스(Bacillis anthracis), 바실리스 서브틸리스(Bacillis subtilis)), 락토바실러스(Lactobacillus) spp., 클로스트리디움(Clostridium) spp. (예를 들어, 클로스트리디움 테타니(Clostridium tetani), 클로스트리디움 페르프린겐스(Clostridium perfringens), 클로스트리디움 노비이(Clostridium novyii)), 미코박테리움(Mycobacterium) spp. (예를 들어, 미코박테리움 투베르쿨로시스(Mycobacterium tuberculosis)), 시겔라(Shigella) spp. (예를 들어, 시겔라 플렉스네리(Shigella flexneri), 시겔라 디센테리아에(Shigella dysenteriae)), 살모넬라(Salmonella) spp. (예를 들어, 살모넬라 티피(Salmonella typhi), 살모넬라 엔테리티디스(Salmonella enteritidis)), 클렙시엘라(Klebsiella) spp. (예를 들어, 클렙시엘라 뉴모니아에(Klebsiella pneumoniae)), 예르시니아(Yersinia) spp. (예를 들어, 예르시니아 페스티스(Yersinia pestis)), 세라티아(Serratia) spp. (예를 들어, 세라티아 마르세센스(Serratia marcescens)), 슈도모나스(Pseudomonas) spp. (예를 들어, 슈도모나스 아에루기노사(Pseudomonas aeruginosa), 슈도모나스 말레이(Pseudomonas mallei)), 에이케넬라(Eikenella) spp. (예를 들어, 에이케넬라 코로덴스(Eikenella corrodens)), 하에모필루스(Haemophilus) spp. (예를 들어, 하에모필루스 인플루엔자(Haemophilus influenza), 하에모필루스 두크레이이(Haemophilus ducreyi), 하에모필루스 아에깁티우스(Haemophilus aegyptius)), 비브리오(Vibrio) spp. (예를 들어, 비브리오 콜레라(Vibrio cholera), 비브리오 나트리에겐스(Vibrio natriegens)), 레기오넬라(Legionella) spp. (예를 들어, 레기오넬라 미크다데이(Legionella micdadei), 레기오넬라 보제마니(Legionella bozemani)), 브루셀라(Brucella) spp. (예를 들어, 브루셀라 아보르투스(Brucella abortus)), 미코플라스마(Mycoplasma) spp. (예를 들어, 미코플라스마 뉴모니아에(Mycoplasma pneumoniae)) 또는 스트렙토미세스(Streptomyces) spp. (예를 들어 스트렙토미세스 코엘리콜로르(Streptomyces coelicolor), 스트렙토미세스 리비단스(Streptomyces lividans), 스트렙토미세스 알부스(Streptomyces albus))일 수 있다.
전달 및 선택 방법
일부 실시양태에서, 본 개시내용의 방법은 세포를 포함하는 조성물로 벡터를 전달하고, 진핵생물 세포를 생성하기 위해 세포로의 핵산 (예를 들어, 제1, 제2 및 제3 벡터)의 도입을 허용하고 세포에서 핵산 발현을 허용하는 조건 하에 조성물을 유지하는 것을 포함한다. 세포로의 핵산 (예를 들어, 벡터)의 도입에 필요한 조건은 널리 공지되어 있다. 이들 조건은 예를 들어, (원핵생물 세포의) 형질전환 조건, (진핵생물 세포의) 형질감염 조건, (바이러스/바이러스 벡터를 통한) 형질도입 조건, 및 전기천공 조건을 포함하며, 이들 중 임의의 것이 본원에 제공된 바와 같이 사용될 수 있다. 그러므로, 일부 실시양태에서, 본 개시내용의 방법은 진핵생물 (예를 들어 포유동물) 세포를 형질감염시키는 것을 포함하는 반면, 다른 실시양태에서, 방법은 원핵생물 (예를 들어, 박테리아) 세포를 형질전환시키는 것을 포함한다.
트랜스제닉, 예를 들어, 다중-트랜스제닉 세포, 예컨대 이중, 삼중, 및/또는 사중 트랜스제닉 세포의 선택은 사용되는 선택가능한 마커의 유형에 좌우된다. 예를 들어, 선택가능한 마커 단백질이 항생제 내성 단백질인 경우, 선택 단계는 세포를 특정 항생제에 노출시키고, 생존하는 세포만을 선택하는 것을 포함할 수 있다. 선택가능한 마커 단백질이 형광 단백질인 경우, 선택 단계는 단순히 세포를 현미경 하에서 관찰하고, 형광을 내는 세포를 선택하는 것을 포함할 수 있거나, 선택 단계는 다른 형광 선택 방법, 예컨대 형광-활성화 세포 분류법 (FACS) 분류법을 포함할 수 있다.
일부 실시양태에서, 세포는 본원에 기재된 바와 같은 핵산을 보유하는 바이러스 벡터 (예를 들어, 바이러스)로 형질도입된다. 일부 실시양태에서, 형질도입 (또는 다른 형질감염 방법) 전에, 세포를 예를 들어, 웰 당 1x104 내지 1x106개의 밀도로 웰 플레이트 (예를 들어, 12-웰 플레이트) 상에 씨딩한다. 일부 실시양태에서, 100 μL 내지 500 μL, 예를 들어, 100, 150, 200, 250, 300, 350, 400, 450, 또는 500 μL의 각각의 바이러스 벡터를 각각의 웰에 첨가한다.
키트
본 개시내용은 또한 예를 들어, 트랜스제닉 세포 및/또는 유기체를 생성하고 스크리닝하는데 사용될 수 있는 키트를 제공한다. 키트는 본원에 기재된 바와 같은 임의의 둘 이상의 구성성분을 포함할 수 있다. 예를 들어, 키트는 (a) N-말단 인테인 단백질 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 선택가능한 마커 단백질 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터; 및 (b) 제2 선택가능한 마커 단백질 단편으로부터 상류에 있는, C-말단 인테인 단백질 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터를 포함할 수 있으며, 여기서 N-말단 인테인 단백질 단편 및 C-말단 인테인 단백질 단편은 제2 선택가능한 마커 단백질 단편으로의 제1 선택가능한 마커 단백질 단편의 연결을 촉매하여 전장 항생제 내성 단백질을 생성한다.
일부 실시양태에서, 키트는 본원에 기재된 바와 같은 임의의 둘 이상의 구성성분을 포함한다. 예를 들어, 키트는 (a) 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 항생제 내성 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터, (b) 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 항생제 내성 단백질의 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, 및 (c) 항생제 내성 단백질의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제3 벡터를 포함할 수 있으며, 여기서 제1 인테인의 N-말단 단편 및 C-말단 단편은 항생제 내성 단백질의 중심 단편으로의 항생제 내성 단백질의 N-말단 단편의 연결을 촉매하고, 제2 인테인의 N-말단 단편 및 C-말단 단편은 항생제 내성 단백질의 C-말단 단편으로의 항생제 내성 단백질의 중심 단편의 연결을 촉매하여 전장 항생제 내성 단백질을 생성한다.
일부 실시양태에서, 키트는 다음 구성성분: 완충제, 염, 클로닝 효소 (예를 들어, LR 클로나제), 감응성 세포 (예를 들어, 감응성 박테리아 세포), 형질감염 시약, 항생제, 및/또는 본원에 기재된 방법의 수행에 대한 지침서 중 임의의 하나 이상을 추가로 포함한다.
<추가 실시양태>
본 개시내용의 추가 실시양태는 하기 번호의 단락에 포함된다:
1. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 항생제 내성 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터; 및
(b) (i) 항생제 내성 단백질의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터
를 진핵생물 세포로 전달하는 것을 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 항생제 내성 단백질의 N-말단 단편 및 C-말단 단편의 연결을 촉매하여 전장 항생제 내성 단백질을 생성하는 것인 방법.
2. 단락 1에 있어서, 트랜스제닉 진핵생물 세포를 생성하기 위해 진핵생물 세포로의 제1 및 제2 벡터의 도입을 허용하는 조건 하에 진핵생물 세포를 유지하는 것을 추가로 포함하는 방법.
3. 단락 2에 있어서, 전장 항생제 내성 단백질을 포함하는 트랜스제닉 진핵생물 세포를 선택하는 것을 추가로 포함하는 방법.
4. 단락 1 내지 3 중 어느 한 단락에 있어서, 진핵생물 세포가 포유동물 세포인 방법.
5. 단락 1 내지 4 중 어느 한 단락에 있어서, 항생제 내성 단백질이 히그로마이신, G418, 퓨로마이신, 플레오마이신 D1 또는 블라스티시딘에 대한 내성을 부여하는 것인 방법.
6. 단락 1 내지 5 중 어느 한 단락에 있어서, 인테인이 분할 인테인인 방법.
7. 단락 6에 있어서, 분할 인테인이 자연 분할 인테인인 방법.
8. 단락 7에 있어서, 자연 분할 인테인이 DnaE 인테인으로부터 선택된 것인 방법.
9. 단락 8에 있어서, DnaE 인테인이 시네코시스티스 sp. DnaE (SspDnaE) 인테인 및 노스톡 푼크티포르메 (NpuDnaE) 인테인으로부터 선택된 것인 방법.
10. 단락 6에 있어서, 분할 인테인이 조작된 분할 인테인인 방법.
11. 단락 10에 있어서, 조작된 분할 인테인이 DnaB 인테인으로부터 조작된 것인 방법.
12. 단락 11에 있어서, 조작된 분할 인테인이 SspDnaB S1 인테인인 방법.
13. 단락 12에 있어서, 조작된 분할 인테인이 GyrB 인테인으로부터 조작된 것인 방법.
14. 단락 13에 있어서, 조작된 분할 인테인이 SspGyrB S11 인테인인 방법.
15. 단락 1 내지 14 중 어느 한 단락에 있어서, 제1 및/또는 제2 분자가 단백질인 방법.
16. 단락 1 내지 15 중 어느 한 단락에 있어서, 제1 및/또는 제2 분자가 비-코딩 리보핵산 (RNA)인 방법.
17. 단락 16에 있어서, 비-코딩 RNA가 마이크로RNA (miRNA), 안티센스 RNA, 짧은-간섭 RNA (siRNA) 또는 짧은-헤어핀 RNA (shRNA)인 방법.
18. 단락 1 내지 17 중 어느 한 단락에 있어서, 제1 및/또는 제2 벡터가 플라스미드 벡터 또는 바이러스 벡터인 방법.
19. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, hygB 유전자의 N-말단 단편 및 (ii) 관심있는 제1 분자를 포함하는 제1 벡터; 및
(b) (ii) hygB 유전자의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 포함하는 제2 벡터
를 진핵생물 세포로 전달하는 것을 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 hygB 유전자의 C-말단 단편에 의해 코딩된 단백질 단편으로의 hygB 유전자의 N-말단 단편에 의해 코딩된 단백질 단편의 연결을 촉매하여 전장 히그로마이신 B 포스포트랜스퍼라제를 생성하는 것인 방법.
20. 단락 19에 있어서, 제2 hygB 유전자 단편에 의해 코딩된 단백질 단편의 첫 번째 아미노산이 시스테인인 방법.
21. 단락 23에 있어서,
hygB 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 1-89에 의해 확인된 아미노산 서열을 포함하고, hygB 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 90-341에 의해 확인된 아미노산 서열을 포함하거나;
hygB 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 1-200에 의해 확인된 아미노산 서열을 포함하고, hygB 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 201-341에 의해 확인된 아미노산 서열을 포함하거나;
hygB 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 1-53에 의해 확인된 아미노산 서열을 포함하고, hygB 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 54-341에 의해 확인된 아미노산 서열을 포함하거나;
hygB 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 1-240에 의해 확인된 아미노산 서열을 포함하고, hygB 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 241-341에 의해 확인된 아미노산 서열을 포함하거나;
hygB 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 1-292에 의해 확인된 아미노산 서열을 포함하고, hygB 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 293-341에 의해 확인된 아미노산 서열을 포함하는 것인 방법.
22. 단락 23 내지 21 중 어느 한 단락에 있어서,
인테인의 N-말단 단편이 서열식별번호: 16에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 17에 의해 확인되거나;
인테인의 N-말단 단편이 서열식별번호: 7에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 8에 의해 확인되거나; 또는
인테인의 N-말단 단편이 서열식별번호: 18 또는 서열식별번호: 9에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 19 또는 서열식별번호: 10에 의해 확인된 것인 방법.
23. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, bsr 유전자의 N-말단 단편 및 (ii) 관심있는 제1 분자를 포함하는 제1 벡터; 및
(b) (ii) bsr 유전자의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 포함하는 제2 벡터
를 진핵생물 세포로 전달하는 것을 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 bsr 유전자의 C-말단 단편에 의해 코딩된 단백질 단편으로의 bsr 유전자의 N-말단 단편에 의해 코딩된 단백질 단편의 연결을 촉매하여 전장 블라스티시딘-S 데아미나제를 생성하는 것인 방법.
24. 단락 23에 있어서, bsr 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 4의 아미노산 1-102에 의해 확인된 아미노산 서열을 포함하고, bsr 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 4의 아미노산 103-140에 의해 확인된 아미노산 서열을 포함하는 것인 방법.
25. 단락 22 또는 23에 있어서,
인테인의 N-말단 단편이 서열식별번호: 16에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 17에 의해 확인되거나;
인테인의 N-말단 단편이 서열식별번호: 7에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 8에 의해 확인되거나; 또는
인테인의 N-말단 단편이 서열식별번호: 18 또는 서열식별번호: 9에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 19 또는 서열식별번호: 10에 의해 확인된 것인 방법.
26. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, pac 유전자의 N-말단 단편 및 (ii) 관심있는 제1 분자를 포함하는 제1 벡터; 및
(b) (ii) pac 유전자의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 포함하는 제2 벡터
를 진핵생물 세포로 전달하는 것을 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 pac 유전자의 C-말단 단편에 의해 코딩된 단백질 단편으로의 pac 유전자의 N-말단 단편에 의해 코딩된 단백질 단편의 연결을 촉매하여 전장 퓨로마이신 N-아세틸-트랜스퍼라제를 생성하는 것인 방법.
27. 단락 26에 있어서,
pac 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 2의 아미노산 1-63에 의해 확인된 아미노산 서열을 포함하고, pac 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 2의 아미노산 64-199에 의해 확인된 아미노산 서열을 포함하거나;
pac 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 2의 아미노산 1-119에 의해 확인된 아미노산 서열을 포함하고, pac 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 2의 아미노산 120-199에 의해 확인된 아미노산 서열을 포함하거나;
pac 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 2의 아미노산 1-100에 의해 확인된 아미노산 서열을 포함하고, pac 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 2의 아미노산 101-199에 의해 확인된 아미노산 서열을 포함하는 것인 방법.
28. 단락 26 또는 27에 있어서,
인테인의 N-말단 단편이 서열식별번호: 16에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 17에 의해 확인되거나;
인테인의 N-말단 단편이 서열식별번호: 7에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 8에 의해 확인되거나; 또는
인테인의 N-말단 단편이 서열식별번호: 18 또는 서열식별번호: 9에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 19 또는 서열식별번호: 10에 의해 확인된 것인 방법.
29. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, neo 유전자의 N-말단 단편 및 (ii) 관심있는 제1 분자를 포함하는 제1 벡터; 및
(b) (ii) neo 유전자의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 포함하는 제2 벡터
를 진핵생물 세포로 전달하는 것을 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 neo 유전자의 C-말단 단편에 의해 코딩된 단백질 단편으로의 neo 유전자의 N-말단 단편에 의해 코딩된 단백질 단편의 연결을 촉매하여 전장 아미노글리코시드 3'-포스포트랜스퍼라제를 생성하는 것인 방법.
30. 단락 29에 있어서,
neo 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 3의 아미노산 1-133에 의해 확인된 아미노산 서열을 포함하고, neo 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 3의 아미노산 134-267에 의해 확인된 아미노산 서열을 포함하거나; 또는
neo 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 3의 아미노산 1-194에 의해 확인된 아미노산 서열을 포함하고, neo 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 3의 아미노산 195-267에 의해 확인된 아미노산 서열을 포함하는 것인 방법.
31. 단락 29 또는 30에 있어서,
인테인의 N-말단 단편이 서열식별번호: 16에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 17에 의해 확인되거나;
인테인의 N-말단 단편이 서열식별번호: 7에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 8에 의해 확인되거나; 또는
인테인의 N-말단 단편이 서열식별번호: 18 또는 서열식별번호: 9에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 19 또는 서열식별번호: 10에 의해 확인된 것인 방법.
32. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 형광 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터; 및
(b) (ii) 형광 단백질의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터
를 진핵생물 세포를 포함하는 조성물로 전달하는 것을 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 형광 단백질의 C-말단 단편으로의 형광 단백질의 N-말단 단편의 연결을 촉매하여 전장 형광 단백질을 생성하는 것인 방법.
33. 단락 51에 있어서, 트랜스제닉 진핵생물 세포를 생성하기 위해 진핵생물 세포로의 제1 및 제2 벡터의 도입을 허용하는 조건 하에 진핵생물 세포를 유지하는 것을 추가로 포함하는 방법.
34. 단락 33에 있어서, 전장 형광 단백질을 포함하는 트랜스제닉 진핵생물 세포를 선택하는 것을 추가로 포함하는 방법.
35. 단락 32 내지 34 중 어느 한 단락에 있어서, 진핵생물 세포가 포유동물 세포인 방법.
36. 단락 32 내지 35 중 어느 한 단락에 있어서, 형광 단백질이 TagCFP, mTagCFP2, Czurite, ECFP2, mKalama1, Sirius, Sapphire, T-Sapphire, ECFP, Cerulean, SCFP3C, mTurquoise, mTurquoise2, 모노머 Midoriishi-Cyan, TagCFP, mTFP1, EGFP, Emerald, Superfolder GFP, 모노머 Czami Green, TagGFP2, mUKG, mWasabi, Clover, mNeonGreen, EYFP, Citrine, Venus, SYFP2, TagYFP, 모노머 Kusabira-Orange, mKOκ, mKO2, mOrange, mOrange2, mRaspberry, mCherry, mStrawberry, mTangerine, tdTomato, TagRFP, TagRFP-T, mCpple, mRuby, mRuby2, mPlum, HcRed-Tandem, mKate2, mNeptune, NirFP, TagRFP657, IFP1.4 및 iRFP로부터 선택된 것인 방법.
37. 단락 32 내지 36 중 어느 한 단락에 있어서, 인테인이 분할 인테인인 방법.
38. 단락 37에 있어서, 분할 인테인이 자연 분할 인테인인 방법.
39. 단락 38에 있어서, 자연 분할 인테인이 DnaE 인테인으로부터 선택된 것인 방법.
40. 단락 39에 있어서, DnaE 인테인이 시네코시스티스 sp. DnaE (SspDnaE) 인테인 및 노스톡 푼크티포르메 (NpuDnaE) 인테인으로부터 선택된 것인 방법.
41. 단락 40에 있어서, 분할 인테인이 조작된 분할 인테인인 방법.
42. 단락 41에 있어서, 조작된 분할 인테인이 DnaB 인테인으로부터 조작된 것인 방법.
43. 단락 42에 있어서, 조작된 분할 인테인이 SspDnaB S1 인테인인 방법.
44. 단락 42에 있어서, 조작된 분할 인테인이 GyrB 인테인으로부터 조작된 것인 방법.
45. 단락 44에 있어서, 조작된 분할 인테인이 SspGyrB S11 인테인인 방법.
46. 단락 32 내지 45 중 어느 한 단락에 있어서, 제1 및/또는 제2 분자가 단백질인 방법.
47. 단락 32 내지 46 중 어느 한 단락에 있어서, 제1 및/또는 제2 분자가 비-코딩 리보핵산 (RNA)인 방법.
48. 단락 47에 있어서, 비-코딩 RNA가 마이크로RNA (miRNA), 안티센스 RNA, 짧은-간섭 RNA (siRNA) 또는 짧은-헤어핀 RNA (shRNA)인 방법.
49. 단락 32 내지 48 중 어느 한 단락에 있어서, 제1 및/또는 제2 벡터가 플라스미드 벡터 또는 바이러스 벡터인 방법.
50. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, egfp 유전자의 N-말단 단편 및 (ii) 관심있는 제1 분자를 포함하는 제1 벡터; 및
(b) (ii) egfp 유전자의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 포함하는 제2 벡터
를 진핵생물 세포로 전달하는 것을 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 egfp 유전자의 C-말단 단편에 의해 코딩된 단백질 단편으로의 egfp 유전자의 N-말단 단편에 의해 코딩된 단백질 단편의 연결을 촉매하여 전장 EGFP 단백질을 생성하는 것인 방법.
51. 단락 50에 있어서, egfp 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 5의 아미노산 1-175에 의해 확인된 아미노산 서열을 포함하고, egfp 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 5의 아미노산 175-239에 의해 확인된 아미노산 서열을 포함하는 것인 방법.
52. 단락 50 또는 51에 있어서,
인테인의 N-말단 단편이 서열식별번호: 16에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 17에 의해 확인되거나;
인테인의 N-말단 단편이 서열식별번호: 7에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 8에 의해 확인되거나; 또는
인테인의 N-말단 단편이 서열식별번호: 18 또는 서열식별번호: 9에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 19 또는 서열식별번호: 10에 의해 확인된 것인 방법.
53. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, mScarlet 유전자의 N-말단 단편 및 (ii) 관심있는 제1 분자를 포함하는 제1 벡터; 및
(b) (ii) mScarlet 유전자의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 포함하는 제2 벡터
를 진핵생물 세포로 전달하는 것을 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 mScarlet 유전자의 C-말단 단편에 의해 코딩된 단백질 단편으로의 mScarlet 유전자의 N-말단 단편에 의해 코딩된 단백질 단편의 연결을 촉매하여 전장 mScarlet 단백질을 생성하는 것인 방법.
54. 단락 53에 있어서,
mScarlet 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 1-46에 의해 확인된 아미노산 서열을 포함하고, mScarlet 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 47-232에 의해 확인된 아미노산 서열을 포함하거나;
mScarlet 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 1-48에 의해 확인된 아미노산 서열을 포함하고, mScarlet 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 49-232에 의해 확인된 아미노산 서열을 포함하거나;
mScarlet 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 1-51에 의해 확인된 아미노산 서열을 포함하고, mScarlet 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 52-232에 의해 확인된 아미노산 서열을 포함하거나;
mScarlet 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 1-75에 의해 확인된 아미노산 서열을 포함하고, mScarlet 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 76-232에 의해 확인된 아미노산 서열을 포함하거나;
mScarlet 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 1-122에 의해 확인된 아미노산 서열을 포함하고, mScarlet 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 123-232에 의해 확인된 아미노산 서열을 포함하거나;
mScarlet 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 1-140에 의해 확인된 아미노산 서열을 포함하고, mScarlet 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 141-232에 의해 확인된 아미노산 서열을 포함하거나;
mScarlet 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 1-163에 의해 확인된 아미노산 서열을 포함하고, mScarlet 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 164-232에 의해 확인된 아미노산 서열을 포함하는 것인 방법.
55. 단락 53 또는 54에 있어서,
인테인의 N-말단 단편이 서열식별번호: 16에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 17에 의해 확인되거나;
인테인의 N-말단 단편이 서열식별번호: 7에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 8에 의해 확인되거나; 또는
인테인의 N-말단 단편이 서열식별번호: 18 또는 서열식별번호: 9에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 19 또는 서열식별번호: 10에 의해 확인된 것인 방법.
56. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 항생제 내성 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터; 및
(b) (i) 항생제 내성 단백질의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터
를 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 항생제 내성 단백질의 N-말단 단편 및 C-말단 단편의 연결을 촉매하여 전장 항생제 내성 단백질을 생성하는 것인 진핵생물 세포.
57. 단락 56에 있어서, 진핵생물 세포가 포유동물 세포인 세포.
58. 단락 56 또는 57에 있어서, 항생제 내성 단백질이 히그로마이신, G418, 퓨로마이신, 플레오마이신 D1 또는 블라스티시딘에 대한 내성을 부여하는 것인 세포.
59. 단락 56 내지 58 중 어느 한 단락에 있어서, 인테인이 분할 인테인인 세포.
60. 단락 59에 있어서, 분할 인테인이 자연 분할 인테인인 세포.
61. 단락 60에 있어서, 자연 분할 인테인이 DnaE 인테인으로부터 선택된 것인 세포.
62. 단락 61에 있어서, DnaE 인테인이 시네코시스티스 sp. DnaE (SspDnaE) 인테인 및 노스톡 푼크티포르메 (NpuDnaE) 인테인으로부터 선택된 것인 세포.
63. 단락 59에 있어서, 분할 인테인이 조작된 분할 인테인인 세포.
64. 단락 63에 있어서, 조작된 분할 인테인이 DnaB 인테인으로부터 조작된 것인 세포.
65. 단락 64에 있어서, 조작된 분할 인테인이 SspDnaB S1 인테인인 세포.
66. 단락 65에 있어서, 조작된 분할 인테인이 GyrB 인테인으로부터 조작된 것인 세포.
67. 단락 66에 있어서, 조작된 분할 인테인이 SspGyrB S11 인테인인 세포.
68. 단락 56 내지 67 중 어느 한 단락에 있어서, 제1 및/또는 제2 분자가 단백질인 세포.
69. 단락 56 내지 68 중 어느 한 단락에 있어서, 제1 및/또는 제2 분자가 비-코딩 리보핵산 (RNA)인 세포.
70. 단락 69에 있어서, 비-코딩 RNA가 마이크로RNA (miRNA), 안티센스 RNA, 짧은-간섭 RNA (siRNA) 또는 짧은-헤어핀 RNA (shRNA)인 세포.
71. 단락 56 내지 70 중 어느 한 단락에 있어서, 제1 및/또는 제2 벡터가 플라스미드 벡터 또는 바이러스 벡터인 세포.
72. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, hygB 유전자의 N-말단 단편 및 (ii) 관심있는 제1 분자를 포함하는 제1 벡터; 및
(b) (ii) hygB 유전자의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 포함하는 제2 벡터
를 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 hygB 유전자의 C-말단 단편에 의해 코딩된 단백질 단편으로의 hygB 유전자의 N-말단 단편에 의해 코딩된 단백질 단편의 연결을 촉매하여 전장 히그로마이신 B 포스포트랜스퍼라제를 생성하는 것인 세포.
73. 단락 72에 있어서, 제2 hygB 유전자 단편에 의해 코딩된 단백질 단편의 첫 번째 아미노산이 시스테인인 세포.
74. 단락 73에 있어서,
hygB 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 1-89에 의해 확인된 아미노산 서열을 포함하고, hygB 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 90-341에 의해 확인된 아미노산 서열을 포함하거나;
hygB 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 1-200에 의해 확인된 아미노산 서열을 포함하고, hygB 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 201-341에 의해 확인된 아미노산 서열을 포함하거나;
hygB 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 1-53에 의해 확인된 아미노산 서열을 포함하고, hygB 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 54-341에 의해 확인된 아미노산 서열을 포함하거나;
hygB 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 1-240에 의해 확인된 아미노산 서열을 포함하고, hygB 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 241-341에 의해 확인된 아미노산 서열을 포함하거나;
hygB 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 1-292에 의해 확인된 아미노산 서열을 포함하고, hygB 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 1의 아미노산 293-341에 의해 확인된 아미노산 서열을 포함하는 것인 세포.
75. 단락 72 내지 74 중 어느 한 단락에 있어서,
인테인의 N-말단 단편이 서열식별번호: 16에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 17에 의해 확인되거나;
인테인의 N-말단 단편이 서열식별번호: 7에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 8에 의해 확인되거나; 또는
인테인의 N-말단 단편이 서열식별번호: 18 또는 서열식별번호: 9에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 19 또는 서열식별번호: 10에 의해 확인된 것인 세포.
76. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, bsr 유전자의 N-말단 단편 및 (ii) 관심있는 제1 분자를 포함하는 제1 벡터; 및
(b) (ii) bsr 유전자의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 포함하는 제2 벡터
를 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 bsr 유전자의 C-말단 단편에 의해 코딩된 단백질 단편으로의 bsr 유전자의 N-말단 단편에 의해 코딩된 단백질 단편의 연결을 촉매하여 전장 블라스티시딘-S 데아미나제를 생성하는 것인 진핵생물 세포.
77. 단락 76에 있어서, bsr 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 4의 아미노산 1-102에 의해 확인된 아미노산 서열을 포함하고, bsr 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 4의 아미노산 103-140에 의해 확인된 아미노산 서열을 포함하는 것인 세포.
78. 단락 76 또는 77에 있어서,
인테인의 N-말단 단편이 서열식별번호: 16에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 17에 의해 확인되거나;
인테인의 N-말단 단편이 서열식별번호: 7에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 8에 의해 확인되거나; 또는
인테인의 N-말단 단편이 서열식별번호: 18 또는 서열식별번호: 9에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 19 또는 서열식별번호: 10에 의해 확인된 것인 세포.
79. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, pac 유전자의 N-말단 단편 및 (ii) 관심있는 제1 분자를 포함하는 제1 벡터; 및
(b) (ii) pac 유전자의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 포함하는 제2 벡터
를 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 pac 유전자의 C-말단 단편에 의해 코딩된 단백질 단편으로의 pac 유전자의 N-말단 단편에 의해 코딩된 단백질 단편의 연결을 촉매하여 전장 퓨로마이신 N-아세틸-트랜스퍼라제를 생성하는 것인 진핵생물 세포.
80. 단락 79에 있어서,
pac 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 2의 아미노산 1-63에 의해 확인된 아미노산 서열을 포함하고, pac 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 2의 아미노산 64-199에 의해 확인된 아미노산 서열을 포함하거나;
pac 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 2의 아미노산 1-119에 의해 확인된 아미노산 서열을 포함하고, pac 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 2의 아미노산 120-199에 의해 확인된 아미노산 서열을 포함하거나;
pac 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 2의 아미노산 1-100에 의해 확인된 아미노산 서열을 포함하고, pac 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 2의 아미노산 101-199에 의해 확인된 아미노산 서열을 포함하는 것인 세포.
81. 단락 79 또는 80에 있어서,
인테인의 N-말단 단편이 서열식별번호: 16에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 17에 의해 확인되거나;
인테인의 N-말단 단편이 서열식별번호: 7에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 8에 의해 확인되거나; 또는
인테인의 N-말단 단편이 서열식별번호: 18 또는 서열식별번호: 9에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 19 또는 서열식별번호: 10에 의해 확인된 것인 세포.
82. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, neo 유전자의 N-말단 단편 및 (ii) 관심있는 제1 분자를 포함하는 제1 벡터; 및
(b) (ii) neo 유전자의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 포함하는 제2 벡터
를 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 neo 유전자의 C-말단 단편에 의해 코딩된 단백질 단편으로의 neo 유전자의 N-말단 단편에 의해 코딩된 단백질 단편의 연결을 촉매하여 전장 아미노글리코시드 3'-포스포트랜스퍼라제를 생성하는 것인 진핵생물 세포.
83. 단락 82에 있어서,
neo 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 3의 아미노산 1-133에 의해 확인된 아미노산 서열을 포함하고, neo 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 3의 아미노산 134-267에 의해 확인된 아미노산 서열을 포함하거나; 또는
neo 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 3의 아미노산 1-194에 의해 확인된 아미노산 서열을 포함하고, neo 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 3의 아미노산 195-267에 의해 확인된 아미노산 서열을 포함하는 것인 세포.
84. 단락 82 또는 83에 있어서,
인테인의 N-말단 단편이 서열식별번호: 16에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 17에 의해 확인되거나;
인테인의 N-말단 단편이 서열식별번호: 7에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 8에 의해 확인되거나; 또는
인테인의 N-말단 단편이 서열식별번호: 18 또는 서열식별번호: 9에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 19 또는 서열식별번호: 10에 의해 확인된 것인 세포.
85. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 형광 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터; 및
(b) (ii) 형광 단백질의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터
를 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 형광 단백질의 C-말단 단편으로의 형광 단백질의 N-말단 단편의 연결을 촉매하여 전장 형광 단백질을 생성하는 것인 진핵생물 세포.
86. 단락 85에 있어서, 트랜스제닉 진핵생물 세포를 생성하기 위해 진핵생물 세포로의 제1 및 제2 벡터의 도입을 허용하는 조건 하에 진핵생물 세포를 유지하는 것을 추가로 포함하는 세포.
87. 단락 86에 있어서, 전장 형광 단백질을 포함하는 트랜스제닉 진핵생물 세포를 선택하는 것을 추가로 포함하는 세포.
88. 단락 85 내지 87 중 어느 한 단락에 있어서, 진핵생물 세포가 포유동물 세포인 세포.
89. 단락 85 내지 88 중 어느 한 단락에 있어서, 형광 단백질이 TagCFP, mTagCFP2, Czurite, ECFP2, mKalama1, Sirius, Sapphire, T-Sapphire, ECFP, Cerulean, SCFP3C, mTurquoise, mTurquoise2, 모노머 Midoriishi-Cyan, TagCFP, mTFP1, EGFP, Emerald, Superfolder GFP, 모노머 Czami Green, TagGFP2, mUKG, mWasabi, Clover, mNeonGreen, EYFP, Citrine, Venus, SYFP2, TagYFP, 모노머 Kusabira-Orange, mKOκ, mKO2, mOrange, mOrange2, mRaspberry, mCherry, mStrawberry, mTangerine, tdTomato, TagRFP, TagRFP-T, mCpple, mRuby, mRuby2, mPlum, HcRed-Tandem, mKate2, mNeptune, NirFP, TagRFP657, IFP1.4 및 iRFP로부터 선택된 것인 세포.
90. 단락 85 내지 89 중 어느 한 단락에 있어서, 인테인이 분할 인테인인 세포.
91. 단락 90에 있어서, 분할 인테인이 자연 분할 인테인인 세포.
92. 단락 91에 있어서, 자연 분할 인테인이 DnaE 인테인으로부터 선택된 것인 세포.
93. 단락 92에 있어서, DnaE 인테인이 시네코시스티스 sp. DnaE (SspDnaE) 인테인 및 노스톡 푼크티포르메 (NpuDnaE) 인테인으로부터 선택된 것인 세포.
94. 단락 93에 있어서, 분할 인테인이 조작된 분할 인테인인 세포.
95. 단락 94에 있어서, 조작된 분할 인테인이 DnaB 인테인으로부터 조작된 것인 세포.
96. 단락 95에 있어서, 조작된 분할 인테인이 SspDnaB S1 인테인인 세포.
97. 단락 95에 있어서, 조작된 분할 인테인이 GyrB 인테인으로부터 조작된 것인 세포.
98. 단락 97에 있어서, 조작된 분할 인테인이 SspGyrB S11 인테인인 세포.
99. 단락 85 내지 98 중 어느 한 단락에 있어서, 제1 및/또는 제2 분자가 단백질인 세포.
100. 단락 85 내지 99 중 어느 한 단락에 있어서, 제1 및/또는 제2 분자가 비-코딩 리보핵산 (RNA)인 세포.
101. 단락 100에 있어서, 비-코딩 RNA가 마이크로RNA (miRNA), 안티센스 RNA, 짧은-간섭 RNA (siRNA) 또는 짧은-헤어핀 RNA (shRNA)인 세포.
102. 단락 85 내지 101 중 어느 한 단락에 있어서, 제1 및/또는 제2 벡터가 플라스미드 벡터 또는 바이러스 벡터인 세포.
103. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, egfp 유전자의 N-말단 단편 및 (ii) 관심있는 제1 분자를 포함하는 제1 벡터; 및
(b) (ii) egfp 유전자의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 포함하는 제2 벡터
를 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 egfp 유전자의 C-말단 단편에 의해 코딩된 단백질 단편으로의 egfp 유전자의 N-말단 단편에 의해 코딩된 단백질 단편의 연결을 촉매하여 전장 EGFP 단백질을 생성하는 것인 진핵생물 세포.
104. 단락 103에 있어서, egfp 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 5의 아미노산 1-175에 의해 확인된 아미노산 서열을 포함하고, egfp 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 5의 아미노산 175-239에 의해 확인된 아미노산 서열을 포함하는 것인 세포.
105. 단락 103 또는 104에 있어서,
인테인의 N-말단 단편이 서열식별번호: 16에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 17에 의해 확인되거나;
인테인의 N-말단 단편이 서열식별번호: 7에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 8에 의해 확인되거나; 또는
인테인의 N-말단 단편이 서열식별번호: 18 또는 서열식별번호: 9에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 19 또는 서열식별번호: 10에 의해 확인된 것인 세포.
106. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, mScarlet 유전자의 N-말단 단편 및 (ii) 관심있는 제1 분자를 포함하는 제1 벡터; 및
(b) (ii) mScarlet 유전자의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 포함하는 제2 벡터
를 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 mScarlet 유전자의 C-말단 단편에 의해 코딩된 단백질 단편으로의 mScarlet 유전자의 N-말단 단편에 의해 코딩된 단백질 단편의 연결을 촉매하여 전장 mScarlet 단백질을 생성하는 것인 진핵생물 세포.
107. 단락 106에 있어서,
mScarlet 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 1-46에 의해 확인된 아미노산 서열을 포함하고, mScarlet 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 47-232에 의해 확인된 아미노산 서열을 포함하거나;
mScarlet 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 1-48에 의해 확인된 아미노산 서열을 포함하고, mScarlet 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 49-232에 의해 확인된 아미노산 서열을 포함하거나;
mScarlet 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 1-51에 의해 확인된 아미노산 서열을 포함하고, mScarlet 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 52-232에 의해 확인된 아미노산 서열을 포함하거나;
mScarlet 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 1-75에 의해 확인된 아미노산 서열을 포함하고, mScarlet 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 76-232에 의해 확인된 아미노산 서열을 포함하거나;
mScarlet 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 1-122에 의해 확인된 아미노산 서열을 포함하고, mScarlet 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 123-232에 의해 확인된 아미노산 서열을 포함하거나;
mScarlet 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 1-140에 의해 확인된 아미노산 서열을 포함하고, mScarlet 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 141-232에 의해 확인된 아미노산 서열을 포함하거나;
mScarlet 유전자의 N-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 1-163에 의해 확인된 아미노산 서열을 포함하고, mScarlet 유전자의 C-말단 단편에 의해 코딩된 단백질 단편이 서열식별번호: 6의 아미노산 164-232에 의해 확인된 아미노산 서열을 포함하는 것인 세포.
108. 단락 106 또는 107에 있어서,
인테인의 N-말단 단편이 서열식별번호: 16에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 17에 의해 확인되거나;
인테인의 N-말단 단편이 서열식별번호: 7에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 8에 의해 확인되거나; 또는
인테인의 N-말단 단편이 서열식별번호: 18 또는 서열식별번호: 9에 의해 확인되고, 인테인의 C-말단 단편이 서열식별번호: 19 또는 서열식별번호: 10에 의해 확인된 것인 세포.
109. 단락 85 내지 108 중 어느 한 단락의 세포를 포함하는 조성물.
110. (a) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 항생제 내성 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터; 및
(b) 항생제 내성 단백질의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터
를 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 항생제 내성 단백질의 N-말단 단편 및 C-말단 단편의 연결을 촉매하여 전장 항생제 내성 단백질을 생성하는 것인 키트.
111. 단락 110에 있어서, 항생제 내성 단백질이 히그로마이신, G418, 퓨로마이신, 플레오마이신 D1 또는 블라스티시딘에 대한 내성을 부여하는 것인 키트.
112. (a) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 형광 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터; 및
(b) 형광 단백질의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터
를 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 형광 단백질의 C-말단 단편으로의 형광 단백질의 N-말단 단편의 연결을 촉매하여 전장 형광 단백질을 생성하는 것인 키트.
113. 단락 112에 있어서, 형광 단백질이 TagCFP, mTagCFP2, Czurite, ECFP2, mKalama1, Sirius, Sapphire, T-Sapphire, ECFP, Cerulean, SCFP3C, mTurquoise, mTurquoise2, 모노머 Midoriishi-Cyan, TagCFP, mTFP1, EGFP, Emerald, Superfolder GFP, 모노머 Czami Green, TagGFP2, mUKG, mWasabi, Clover, mNeonGreen, EYFP, Citrine, Venus, SYFP2, TagYFP, 모노머 Kusabira-Orange, mKOκ, mKO2, mOrange, mOrange2, mRaspberry, mCherry, mStrawberry, mTangerine, tdTomato, TagRFP, TagRFP-T, mCpple, mRuby, mRuby2, mPlum, HcRed-Tandem, mKate2, mNeptune, NirFP, TagRFP657, IFP1.4 및 iRFP로부터 선택된 것인 키트.
114. 단락 110 내지 113 중 어느 한 단락에 있어서, 인테인이 분할 인테인인 키트.
115. 단락 114에 있어서, 분할 인테인이 자연 분할 인테인 또는 조작된 분할 인테인인 키트.
116. 단락 115에 있어서, 자연 분할 인테인이 DnaE 인테인으로부터 선택된 것인 키트.
117. 단락 116에 있어서, DnaE 인테인이 시네코시스티스 sp. DnaE (SspDnaE) 인테인 및 노스톡 푼크티포르메 (NpuDnaE) 인테인으로부터 선택된 것인 키트.
118. 단락 115에 있어서, 조작된 분할 인테인이 DnaB 인테인 또는 GyrB 인테인으로부터 조작된 것인 키트.
119. 단락 118에 있어서, 조작된 분할 인테인이 SspDnaB S1 인테인인 키트.
120. 단락 118에 있어서, 조작된 분할 인테인이 SspGyrB S11 인테인인 키트.
121. 단락 112 내지 120 중 어느 한 단락에 있어서, 다음 구성성분: 완충제, 염, 클로닝 효소, 감응성 세포, 형질감염 시약, 항생제, 및/또는 본원에 기재된 방법의 수행에 대한 지침서 중 임의의 하나 이상을 추가로 포함하는 키트.
122. (a) (i) 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 항생제 내성 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터,
(b) (i) 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 항생제 내성 단백질의 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, 및
(c) (i) 항생제 내성 단백질의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제3 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제3 벡터
를 진핵생물 세포로 전달하는 것을 포함하며, 여기서 제1 인테인의 N-말단 단편 및 C-말단 단편은 항생제 내성 단백질의 중심 단편으로의 항생제 내성 단백질의 N-말단 단편의 연결을 촉매하고, 제2 인테인의 N-말단 단편 및 C-말단 단편은 항생제 내성 단백질의 C-말단 단편으로의 항생제 내성 단백질의 중심 단편의 연결을 촉매하여 전장 항생제 내성 단백질을 생성하는 것인 방법.
123. 단락 112에 있어서, 트랜스제닉 진핵생물 세포를 생성하기 위해 진핵생물 세포로의 제1, 제2 및 제3 벡터의 도입을 허용하는 조건 하에 진핵생물 세포를 유지하는 것을 추가로 포함하는 방법.
124. 단락 123에 있어서, 전장 항생제 내성 단백질을 포함하는 트랜스제닉 진핵생물 세포를 선택하는 것을 추가로 포함하는 방법.
125. 단락 112 내지 124 중 어느 한 단락에 있어서, 진핵생물 세포가 포유동물 세포인 방법.
126. 단락 112 내지 125 중 어느 한 단락에 있어서, 항생제 내성 단백질이 히그로마이신, G418, 퓨로마이신, 플레오마이신 D1 또는 블라스티시딘에 대한 내성을 부여하는 것인 방법.
127. 단락 126에 있어서, 항생제 내성 단백질이 히그로마이신에 대한 내성을 부여하는 것인 방법.
128. 단락 112 내지 127 중 어느 한 단락에 있어서, 제1 인테인이 분할 인테인인 방법.
129. 단락 112 내지 128 중 어느 한 단락에 있어서, 제2 인테인이 분할 인테인인 방법.
130. 단락 128 또는 129에 있어서, 분할 인테인이 자연 분할 인테인인 방법.
131. 단락 130에 있어서, 자연 분할 인테인이 DnaE 인테인으로부터 선택된 것인 방법.
132. 단락 131에 있어서, DnaE 인테인이 시네코시스티스 sp. DnaE (SspDnaE) 인테인 및 노스톡 푼크티포르메 (NpuDnaE) 인테인으로부터 선택된 것인 방법.
133. 단락 132에 있어서, 제1 인테인이 NpuDnaE 인테인이고 제2 인테인이 NpuDnaE 인테인인 방법.
134. 단락 112 내지 133 중 어느 한 단락에 있어서, 관심있는 제1 분자, 관심있는 제2 분자, 관심있는 제3 분자 또는 이들의 임의의 조합이 단백질인 방법.
135. 단락 112 내지 133 중 어느 한 단락에 있어서, 관심있는 제1 분자, 관심있는 제2 분자, 관심있는 제3 분자 또는 이들의 임의의 조합이 비-코딩 리보핵산 (RNA)인 방법.
136. 단락 135에 있어서, 비-코딩 RNA가 마이크로RNA (miRNA), 안티센스 RNA, 짧은-간섭 RNA (siRNA) 또는 짧은-헤어핀 RNA (shRNA)인 방법.
137. 단락 112 내지 136 중 어느 한 단락에 있어서, 제1 벡터, 제2 벡터, 제3 벡터 또는 이들의 임의의 조합이 플라스미드 벡터 또는 바이러스 벡터인 방법.
138. (a) (i) 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, hygB 유전자의 N-말단 단편 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터,
(b) (i) 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, hygB 유전자의 중심 단편으로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, 및
(c) (i) hygB 유전자의 C-말단 단편으로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제3 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제3 벡터
를 진핵생물 세포로 전달하는 것을 포함하며, 여기서 제1 인테인의 N-말단 단편 및 C-말단 단편은 hygB 유전자의 중심 단편에 의해 코딩된 단백질 단편으로의 hygB 유전자의 N-말단 단편에 의해 코딩된 단백질 단편의 연결을 촉매하고, 제2 인테인의 N-말단 단편 및 C-말단 단편은 hygB 유전자의 C-말단 단편에 의해 코딩된 단백질 단편으로의 hygB 유전자의 중심 단편에 의해 코딩된 단백질 단편의 연결을 촉매하여 전장 히그로마이신 B 포스포트랜스퍼라제를 생성하는 것인 방법.
139. 단락 138에 있어서, 제1 벡터가 서열식별번호: 29에 의해 확인된 서열을 코딩하고, 제2 벡터가 서열식별번호: 61에 의해 확인된 서열을 코딩하고, 제3 벡터가 서열식별번호: 23에 의해 확인된 서열을 코딩하는 것인 방법.
140. 단락 138에 있어서, 제1 벡터가 서열식별번호: 21에 의해 확인된 서열을 코딩하고, 제2 벡터가 서열식별번호: 61에 의해 확인된 서열을 코딩하고, 제3 벡터가 서열식별번호: 35에 의해 확인된 서열을 코딩하는 것인 방법.
141. (a) (i) 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 항생제 내성 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터,
(b) (i) 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 항생제 내성 단백질의 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, 및
(c) (i) 항생제 내성 단백질의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제3 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제3 벡터
를 포함하며, 여기서 제1 인테인의 N-말단 단편 및 C-말단 단편은 항생제 내성 단백질의 중심 단편으로의 항생제 내성 단백질의 N-말단 단편의 연결을 촉매하고, 제2 인테인의 N-말단 단편 및 C-말단 단편은 항생제 내성 단백질의 C-말단 단편으로의 항생제 내성 단백질의 중심 단편의 연결을 촉매하여 전장 항생제 내성 단백질을 생성하는 것인 진핵생물 세포.
142. 단락 112에 있어서, 진핵생물 세포가 포유동물 세포인 진핵생물 세포.
143. 단락 141 또는 142에 있어서, 항생제 내성 단백질이 히그로마이신, G418, 퓨로마이신, 플레오마이신 D1 또는 블라스티시딘에 대한 내성을 부여하는 것인 진핵생물 세포.
144. 단락 143에 있어서, 항생제 내성 단백질이 히그로마이신에 대한 내성을 부여하는 것인 진핵생물 세포.
145. 단락 141 내지 144 중 어느 한 단락에 있어서, 제1 인테인이 분할 인테인인 진핵생물 세포.
146. 단락 142 내지 145 중 어느 한 단락에 있어서, 제2 인테인이 분할 인테인인 진핵생물 세포.
147. 단락 145 또는 146에 있어서, 분할 인테인이 자연 분할 인테인인 진핵생물 세포.
148. 단락 147에 있어서, 자연 분할 인테인이 DnaE 인테인으로부터 선택된 것인 진핵생물 세포.
149. 단락 148에 있어서, DnaE 인테인이 시네코시스티스 sp. DnaE (SspDnaE) 인테인 및 노스톡 푼크티포르메 (NpuDnaE) 인테인으로부터 선택된 것인 진핵생물 세포.
150. 단락 149에 있어서, 제1 인테인이 NpuDnaE 인테인이고 제2 인테인이 NpuDnaE 인테인인 진핵생물 세포.
151. 단락 142 내지 150 중 어느 한 단락에 있어서, 관심있는 제1 분자, 관심있는 제2 분자, 관심있는 제3 분자 또는 이들의 임의의 조합이 단백질인 진핵생물 세포.
152. 단락 142 내지 150 중 어느 한 단락에 있어서, 관심있는 제1 분자, 관심있는 제2 분자, 관심있는 제3 분자 또는 이들의 임의의 조합이 비-코딩 리보핵산 (RNA)인 진핵생물 세포.
153. 단락 152에 있어서, 비-코딩 RNA가 마이크로RNA (miRNA), 안티센스 RNA, 짧은-간섭 RNA (siRNA) 또는 짧은-헤어핀 RNA (shRNA)인 진핵생물 세포.
154. 단락 142 내지 153 중 어느 한 단락에 있어서, 제1 벡터, 제2 벡터, 제3 벡터 또는 이들의 임의의 조합이 플라스미드 벡터 또는 바이러스 벡터인 진핵생물 세포.
155. 단락 142 내지 154 중 어느 한 단락의 진핵생물 세포를 포함하는 조성물.
156. (a) 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 항생제 내성 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터,
(b) 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 항생제 내성 단백질의 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, 및
(c) 항생제 내성 단백질의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제3 벡터
를 포함하며, 여기서 제1 인테인의 N-말단 단편 및 C-말단 단편은 항생제 내성 단백질의 중심 단편으로의 항생제 내성 단백질의 N-말단 단편의 연결을 촉매하고, 제2 인테인의 N-말단 단편 및 C-말단 단편은 항생제 내성 단백질의 C-말단 단편으로의 항생제 내성 단백질의 중심 단편의 연결을 촉매하여 전장 항생제 내성 단백질을 생성하는 것인 키트.
157. 단락 156에 있어서, 항생제 내성 단백질이 히그로마이신, G418, 퓨로마이신, 플레오마이신 D1 또는 블라스티시딘에 대한 내성을 부여하는 것인 키트.
158. 단락 157에 있어서, 항생제 내성 단백질이 히그로마이신에 대한 내성을 부여하는 것인 키트.
159. 단락 156 내지 158 중 어느 한 단락에 있어서, 제1 인테인이 분할 인테인인 키트.
160. 단락 156 내지 159 중 어느 한 단락에 있어서, 제2 인테인이 분할 인테인인 키트.
161. 단락 159 또는 160에 있어서, 분할 인테인이 자연 분할 인테인인 키트.
162. 단락 161에 있어서, 자연 분할 인테인이 DnaE 인테인으로부터 선택된 것인 키트.
163. 단락 162에 있어서, DnaE 인테인이 시네코시스티스 sp. DnaE (SspDnaE) 인테인 및 노스톡 푼크티포르메 (NpuDnaE) 인테인으로부터 선택된 것인 키트.
164. 단락 163에 있어서, 제1 인테인이 NpuDnaE 인테인이고 제2 인테인이 NpuDnaE 인테인인 키트.
165. 단락 156 내지 164 중 어느 한 단락에 있어서, 관심있는 제1 분자, 관심있는 제2 분자, 관심있는 제3 분자 또는 이들의 임의의 조합이 단백질인 키트.
166. 단락 156 내지 164 중 어느 한 단락에 있어서, 관심있는 제1 분자, 관심있는 제2 분자, 관심있는 제3 분자 또는 이들의 임의의 조합이 비-코딩 리보핵산 (RNA)인 키트.
167. 단락 166에 있어서, 비-코딩 RNA가 마이크로RNA (miRNA), 안티센스 RNA, 짧은-간섭 RNA (siRNA) 또는 짧은-헤어핀 RNA (shRNA)인 키트.
168. 단락 156 내지 167 중 어느 한 단락에 있어서, 제1 벡터, 제2 벡터, 제3 벡터 또는 이들의 임의의 조합이 플라스미드 벡터 또는 바이러스 벡터인 키트.
169. (a) (i) 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 형광 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터,
(b) (i) 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 형광 단백질의 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, 및
(c) (i) 형광 단백질의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제3 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제3 벡터
를 진핵생물 세포로 전달하는 것을 포함하며, 여기서 제1 인테인의 N-말단 단편 및 C-말단 단편은 형광 단백질의 중심 단편으로의 형광 단백질의 N-말단 단편의 연결을 촉매하고, 제2 인테인의 N-말단 단편 및 C-말단 단편은 형광 단백질의 C-말단 단편으로의 형광 단백질의 중심 단편의 연결을 촉매하여 전장 형광 단백질을 생성하는 것인 방법.
170. 단락 169에 있어서, 트랜스제닉 진핵생물 세포를 생성하기 위해 진핵생물 세포로의 제1, 제2 및 제3 벡터의 도입을 허용하는 조건 하에 진핵생물 세포를 유지하는 것을 추가로 포함하는 방법.
171. 단락 170에 있어서, 전장 형광 단백질을 포함하는 트랜스제닉 진핵생물 세포를 선택하는 것을 추가로 포함하는 방법.
172. 단락 169 내지 171 중 어느 한 단락에 있어서, 진핵생물 세포가 포유동물 세포인 방법.
173. 단락 169 내지 172 중 어느 한 단락에 있어서, 형광 단백질이 TagCFP, mTagCFP2, Czurite, ECFP2, mKalama1, Sirius, Sapphire, T-Sapphire, ECFP, Cerulean, SCFP3C, mTurquoise, mTurquoise2, 모노머 Midoriishi-Cyan, TagCFP, mTFP1, EGFP, Emerald, Superfolder GFP, 모노머 Czami Green, TagGFP2, mUKG, mWasabi, Clover, mNeonGreen, EYFP, Citrine, Venus, SYFP2, TagYFP, 모노머 Kusabira-Orange, mKOκ, mScarlet, mKO2, mOrange, mOrange2, mRaspberry, mCherry, mStrawberry, mTangerine, tdTomato, TagRFP, TagRFP-T, mCpple, mRuby, mRuby2, mPlum, HcRed-Tandem, mKate2, mNeptune, NirFP, TagRFP657, IFP1.4 및 iRFP로부터 선택된 것인 방법.
174. 단락 173에 있어서, 형광 단백질이 mScarlet인 방법.
175. 단락 169 내지 174 중 어느 한 단락에 있어서, 제1 인테인이 분할 인테인인 방법.
176. 단락 169 내지 175 중 어느 한 단락에 있어서, 제2 인테인이 분할 인테인인 방법.
177. 단락 175 또는 176에 있어서, 분할 인테인이 자연 분할 인테인인 방법.
178. 단락 177에 있어서, 자연 분할 인테인이 DnaE 인테인으로부터 선택된 것인 방법.
179. 단락 178에 있어서, DnaE 인테인이 시네코시스티스 sp. DnaE (SspDnaE) 인테인 및 노스톡 푼크티포르메 (NpuDnaE) 인테인으로부터 선택된 것인 방법.
180. 단락 179에 있어서, 제1 인테인이 NpuDnaE 인테인이고 제2 인테인이 NpuDnaE 인테인인 방법.
181. 단락 169 내지 170 중 어느 한 단락에 있어서, 관심있는 제1 분자, 관심있는 제2 분자, 관심있는 제3 분자 또는 이들의 임의의 조합이 단백질인 방법.
182. 단락 169 내지 180 중 어느 한 단락에 있어서, 관심있는 제1 분자, 관심있는 제2 분자, 관심있는 제3 분자 또는 이들의 임의의 조합이 비-코딩 리보핵산 (RNA)인 방법.
183. 단락 182에 있어서, 비-코딩 RNA가 마이크로RNA (miRNA), 안티센스 RNA, 짧은-간섭 RNA (siRNA) 또는 짧은-헤어핀 RNA (shRNA)인 방법.
184. 단락 169 내지 183 중 어느 한 단락에 있어서, 제1 벡터, 제2 벡터, 제3 벡터 또는 이들의 임의의 조합이 플라스미드 벡터 또는 바이러스 벡터인 방법.
185. (a) (i) 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, mScarlet 유전자의 N-말단 단편 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터,
(b) (i) 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, mScarlet 유전자의 중심 단편으로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, 및
(c) (i) mScarlet 유전자의 C-말단 단편으로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제3 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제3 벡터
를 진핵생물 세포로 전달하는 것을 포함하며, 여기서 제1 인테인의 N-말단 단편 및 C-말단 단편은 mScarlet 유전자의 중심 단편에 의해 코딩된 단백질 단편으로의 mScarlet 유전자의 N-말단 단편에 의해 코딩된 단백질 단편의 연결을 촉매하고, 제2 인테인의 N-말단 단편 및 C-말단 단편은 mScarlet 유전자의 C-말단 단편에 의해 코딩된 단백질 단편으로의 mScarlet 유전자의 중심 단편에 의해 코딩된 단백질 단편의 연결을 촉매하여 전장 mScarlet 단백질을 생성하는 것인 방법.
186. 단락 185에 있어서, 제1 벡터가 서열식별번호: 121에 의해 확인된 서열을 코딩하고, 제2 벡터가 서열식별번호: 123에 의해 확인된 서열을 코딩하고, 제3 벡터가 서열식별번호: 125에 의해 확인된 서열을 코딩하는 것인 방법.
187. (a) (i) 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 형광 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터,
(b) (i) 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 형광 단백질의 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, 및
(c) (i) 형광 단백질의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제3 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제3 벡터
를 포함하며, 여기서 제1 인테인의 N-말단 단편 및 C-말단 단편은 형광 단백질의 중심 단편으로의 형광 단백질의 N-말단 단편의 연결을 촉매하고, 제2 인테인의 N-말단 단편 및 C-말단 단편은 형광 단백질의 C-말단 단편으로의 형광 단백질의 중심 단편의 연결을 촉매하여 전장 형광 단백질을 생성하는 것인 진핵생물 세포.
188. 단락 187에 있어서, 진핵생물 세포가 포유동물 세포인 진핵생물 세포.
189. 단락 187 또는 188에 있어서, 형광 단백질이 TagCFP, mTagCFP2, Czurite, ECFP2, mKalama1, Sirius, Sapphire, T-Sapphire, ECFP, Cerulean, SCFP3C, mTurquoise, mTurquoise2, 모노머 Midoriishi-Cyan, TagCFP, mTFP1, EGFP, Emerald, Superfolder GFP, 모노머 Czami Green, TagGFP2, mUKG, mWasabi, Clover, mNeonGreen, EYFP, Citrine, Venus, SYFP2, TagYFP, 모노머 Kusabira-Orange, mKOκ, mScarlet, mKO2, mOrange, mOrange2, mRaspberry, mCherry, mStrawberry, mTangerine, tdTomato, TagRFP, TagRFP-T, mCpple, mRuby, mRuby2, mPlum, HcRed-Tandem, mKate2, mNeptune, NirFP, TagRFP657, IFP1.4 및 iRFP로부터 선택된 것인 진핵생물 세포.
190. 단락 189에 있어서, 형광 단백질이 mScarlet인 진핵생물 세포.
191. 단락 187 내지 190 중 어느 한 단락에 있어서, 제1 인테인이 분할 인테인인 진핵생물 세포.
192. 단락 185 내지 191 중 어느 한 단락에 있어서, 제2 인테인이 분할 인테인인 진핵생물 세포.
193. 단락 191 또는 192에 있어서, 분할 인테인이 자연 분할 인테인인 진핵생물 세포.
194. 단락 193에 있어서, 자연 분할 인테인이 DnaE 인테인으로부터 선택된 것인 진핵생물 세포.
195. 단락 194에 있어서, DnaE 인테인이 시네코시스티스 sp. DnaE (SspDnaE) 인테인 및 노스톡 푼크티포르메 (NpuDnaE) 인테인으로부터 선택된 것인 진핵생물 세포.
196. 단락 195에 있어서, 제1 인테인이 NpuDnaE 인테인이고 제2 인테인이 NpuDnaE 인테인인 진핵생물 세포.
197. 단락 185 내지 196 중 어느 한 단락에 있어서, 관심있는 제1 분자, 관심있는 제2 분자, 관심있는 제3 분자 또는 이들의 임의의 조합이 단백질인 진핵생물 세포.
198. 단락 185 내지 196 중 어느 한 단락에 있어서, 관심있는 제1 분자, 관심있는 제2 분자, 관심있는 제3 분자 또는 이들의 임의의 조합이 비-코딩 리보핵산 (RNA)인 진핵생물 세포.
199. 단락 198에 있어서, 비-코딩 RNA가 마이크로RNA (miRNA), 안티센스 RNA, 짧은-간섭 RNA (siRNA) 또는 짧은-헤어핀 RNA (shRNA)인 진핵생물 세포.
200. 단락 185 내지 199 중 어느 한 단락에 있어서, 제1 벡터, 제2 벡터, 제3 벡터 또는 이들의 임의의 조합이 플라스미드 벡터 또는 바이러스 벡터인 진핵생물 세포.
201. 단락 185 내지 200 중 어느 한 단락의 진핵생물 세포를 포함하는 조성물.
202. (a) 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 형광 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터,
(b) 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 형광 단백질의 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, 및
(c) 형광 단백질의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제3 벡터
를 포함하며, 여기서 제1 인테인의 N-말단 단편 및 C-말단 단편은 형광 단백질의 중심 단편으로의 형광 단백질의 N-말단 단편의 연결을 촉매하고, 제2 인테인의 N-말단 단편 및 C-말단 단편은 형광 단백질의 C-말단 단편으로의 형광 단백질의 중심 단편의 연결을 촉매하여 전장 형광 단백질을 생성하는 것인 키트.
203. 단락 202에 있어서, 형광 단백질이 TagCFP, mTagCFP2, Czurite, ECFP2, mKalama1, Sirius, Sapphire, T-Sapphire, ECFP, Cerulean, SCFP3C, mTurquoise, mTurquoise2, 모노머 Midoriishi-Cyan, TagCFP, mTFP1, EGFP, Emerald, Superfolder GFP, 모노머 Czami Green, TagGFP2, mUKG, mWasabi, Clover, mNeonGreen, EYFP, Citrine, Venus, SYFP2, TagYFP, 모노머 Kusabira-Orange, mKOκ, mScarlet, mKO2, mOrange, mOrange2, mRaspberry, mCherry, mStrawberry, mTangerine, tdTomato, TagRFP, TagRFP-T, mCpple, mRuby, mRuby2, mPlum, HcRed-Tandem, mKate2, mNeptune, NirFP, TagRFP657, IFP1.4 및 iRFP로부터 선택된 것인 키트.
204. 단락 203에 있어서, 형광 단백질이 mScarlet인 키트.
205. 단락 202 내지 204 중 어느 한 단락에 있어서, 제1 인테인이 분할 인테인인 키트.
206. 단락 202 내지 205 중 어느 한 단락에 있어서, 제2 인테인이 분할 인테인인 키트.
207. 단락 206에 있어서, 분할 인테인이 자연 분할 인테인인 키트.
208. 단락 207에 있어서, 자연 분할 인테인이 DnaE 인테인으로부터 선택된 것인 키트.
209. 단락 208에 있어서, DnaE 인테인이 시네코시스티스 sp. DnaE (SspDnaE) 인테인 및 노스톡 푼크티포르메 (NpuDnaE) 인테인으로부터 선택된 것인 키트.
210. 단락 209에 있어서, 제1 인테인이 NpuDnaE 인테인이고 제2 인테인이 NpuDnaE 인테인인 키트.
211. 단락 202 내지 210 중 어느 한 단락에 있어서, 관심있는 제1 분자, 관심있는 제2 분자, 관심있는 제3 분자 또는 이들의 임의의 조합이 단백질인 키트.
212. 단락 202 내지 210 중 어느 한 단락에 있어서, 관심있는 제1 분자, 관심있는 제2 분자, 관심있는 제3 분자 또는 이들의 임의의 조합이 비-코딩 리보핵산 (RNA)인 키트.
213. 단락 212에 있어서, 비-코딩 RNA가 마이크로RNA (miRNA), 안티센스 RNA, 짧은-간섭 RNA (siRNA) 또는 짧은-헤어핀 RNA (shRNA)인 키트.
214. 단락 202 내지 213 중 어느 한 단락에 있어서, 제1 벡터, 제2 벡터, 제3 벡터 또는 이들의 임의의 조합이 플라스미드 벡터 또는 바이러스 벡터인 키트.
215. 단락 202 내지 214 중 어느 한 단락에 있어서, 다음 구성성분: 완충제, 염, 클로닝 효소, 감응성 세포, 형질감염 시약, 항생제, 및/또는 본원에 기재된 방법의 수행에 대한 지침서 중 임의의 하나 이상을 추가로 포함하는 키트.
216. (a) (i) N-말단 인테인 단백질 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 선택가능한 마커 단백질 단편 (예를 들어, 항생제 내성 단백질 단편 또는 형광 단백질 단편)을 코딩하는 뉴클레오티드 서열 및 (ii) 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터, 및 (b) (i) 제2 선택가능한 마커 단백질 단편 (예를 들어, 항생제 내성 단백질 단편 또는 형광 단백질 단편)으로부터 상류에 있는, C-말단 인테인 단백질 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터를 진핵생물 세포를 포함하는 조성물로 전달하는 것을 포함하며, 여기서 N-말단 인테인 단백질 단편 및 C-말단 인테인 단백질 단편은 제2 선택가능한 마커 단백질 단편으로의 제1 선택가능한 마커 단백질 단편의 연결을 촉매하여 전장 선택가능한 마커 단백질을 생성하는 것인 트랜스제닉 선택 방법.
217. (a) (i) 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질 (예를 들어, 항생제 내성 단백질 또는 형광 단백질)의 N-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터, (b) (i) 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질의 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, 및 (c) (i) 선택가능한 마커 단백질의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제3 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제3 벡터를 진핵생물 세포로 전달하는 것을 포함하며, 여기서 제1 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 중심 단편으로의 선택가능한 마커 단백질의 N-말단 단편의 연결을 촉매하고, 제2 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 C-말단 단편으로의 선택가능한 마커 단백질의 중심 단편의 연결을 촉매하여 전장 선택가능한 마커 단백질을 생성하는 것인 트랜스제닉 선택 방법.
218. (a) (i) 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질 (예를 들어, 항생제 내성 단백질 또는 형광 단백질)의 N-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터, (b) (i) 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질의 제1 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, (c) (i) 제3 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질의 제2 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제3 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제3 벡터, 및 (d) (i) 선택가능한 마커 단백질의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제3 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제3 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제4 벡터를 진핵생물 세포로 전달하는 것을 포함하며, 여기서 제1 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 제1 중심 단편으로의 선택가능한 마커 단백질의 N-말단 단편의 연결을 촉매하고, 제2 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 제2 중심 단편으로의 선택가능한 마커 단백질의 제1 중심 단편의 연결을 촉매하고, 제3 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 C-말단 단편으로의 선택가능한 마커 단백질의 제2 중심 단편의 연결을 촉매하여 전장 선택가능한 마커 단백질을 생성하는 것인 트랜스제닉 선택 방법.
219. 단락 216 내지 218 중 어느 한 단락에 있어서, 트랜스제닉 진핵생물 세포를 생성하기 위해 진핵생물 세포로의 벡터의 도입을 허용하는 조건 하에 진핵생물 세포를 유지하는 것을 추가로 포함하는 방법.
220. 단락 219에 있어서, 전장 선택가능한 마커 단백질을 포함하는 트랜스제닉 진핵생물 세포를 선택하는 것을 추가로 포함하는 방법.
221. 단락 216 내지 220 중 어느 한 단락에 있어서, 진핵생물 세포가 포유동물 세포인 방법.
222. 단락 216 내지 221 중 어느 한 단락에 있어서, 항생제 내성 단백질이 히그로마이신, G418, 퓨로마이신, 플레오마이신 D1 또는 블라스티시딘에 대한 내성을 부여하는 것인 방법.
223. 단락 216 내지 222 중 어느 한 단락에 있어서, 인테인이 분할 인테인인 방법.
224. 단락 223에 있어서, 분할 인테인이 자연 분할 인테인인 방법.
225. 단락 224에 있어서, 자연 분할 인테인이 DnaE 인테인으로부터 선택된 것인 방법.
226. 단락 225에 있어서, DnaE 인테인이 시네코시스티스 sp. DnaE (SspDnaE) 인테인 및 노스톡 푼크티포르메 (NpuDnaE) 인테인으로부터 선택된 것인 방법.
227. 단락 223에 있어서, 분할 인테인이 조작된 분할 인테인인 방법.
228. 단락 2278에 있어서, 조작된 분할 인테인이 DnaB 인테인으로부터 조작된 것인 방법.
229. 단락 228에 있어서, 조작된 분할 인테인이 SspDnaB S1 인테인인 방법.
230. 단락 229에 있어서, 조작된 분할 인테인이 GyrB 인테인으로부터 조작된 것인 방법.
231. 단락 230에 있어서, 조작된 분할 인테인이 SspGyrB S11 인테인인 방법.
232. 단락 216 내지 231 중 어느 한 단락에 있어서, 분자가 단백질로부터 선택된 것인 방법.
233. 단락 216 내지 231 중 어느 한 단락에 있어서, 분자가 비-코딩 리보핵산 (RNA)으로부터 선택된 것인 방법.
234. 단락 233에 있어서, 비-코딩 RNA가 마이크로RNA (miRNA), 안티센스 RNA, 짧은-간섭 RNA (siRNA) 및 짧은-헤어핀 RNA (shRNA)로부터 선택된 것인 방법.
235. 단락 216 내지 234 중 어느 한 단락에 있어서, 벡터가 플라스미드 벡터 및 바이러스 벡터로부터 선택된 것인 방법.
<실시예>
본 개시내용은 하기 실시예에 의해 추가로 예시된다. 이들 실시예는 본 개시내용의 이해를 돕기 위해 제공되며, 그의 제한으로 해석되어서는 안된다.
실시예 1. 항생제 내성 마커
선택가능한 마커는 종종 원하는 유전자형을 갖는 세포를 단리하기 위해 유전자 조작에 사용된다 [1]. 그러나, 진핵생물 세포에서 사용하기 위한 잘-특징화된 항생제 내성 유전자의 수는 제한되어 있고, 스펙트럼이 일반 실험실에서 장비에 의해 명백하게 식별될 수 있는 형광 단백질의 수는 제한되어 있다. 연구원은 종종 다중 트랜스진을 세포로 혼입시키는 경우 선택가능한 마커를 충분히 선택하지 못하는 문제를 겪는다. 다른 한편, 다중 항생제를 동시에 선택하는 것은 종종 세포에 가혹하다. "선택가능한 마커 재순환"은 제2의 해결책(work-around)을 제공할 수 있으나, 선택 마커의 트랜스제네시스, 선택 및 제거의 다수의 라운드를 필요로 한다 [2]. 다중 트랜스진이 하나의 선택 방식에 의해 동시에 선택되도록 하기 위해, 본 발명자들은 분할 항생제 내성 및 형광 단백질 유전자를 생성하였으며, 여기서 항생제 내성 또는 형광 단백질을 코딩하는 유전자는 단백질 트랜스-스플라이싱에 의해 재연결될 수 있는 인테인 ("마커트론")으로 융합된 2개 이상의 세그먼트로 분할된다 [3] (도 1a). 각각의 마커트론은 특정 트랜스진을 보유하는 트랜스제닉 벡터로 삽입된다. 마커트론의 세트를 함유하는 트랜스제닉 벡터의 전달은 마커트론의 서브세트 또는 완전한 세트를 보유하는 세포를 생성한다. 마커트론의 완전한 세트를 함유하는 세포만이 단백질 스플라이싱을 통해 완전히 재구성된 마커 단백질을 생성하므로 선택을 통해 통과하는 반면, 마커트론의 부분 세트를 갖는 세포는 제거되어, 모든 의도된 트랜스진을 함유하는 세포의 공동선택을 달성한다.
본 발명자들은 이중 트랜스제네시스를 위한 2-마커트론 인테인-분할 내성 (Intres) 유전자의 조작으로 시작하였다. 플랭킹 잔기 및 국소 단백질 폴딩은 인테인-매개 트랜스-스플라이싱의 효율에 영향을 미칠 수 있기 때문에, 본 발명자들은 NpuDnaE [4, 5] 및 SspDnaB [6]로부터 유래된 2개의 잘-특징화된 분할 인테인과 호환가능한 4개의 통상적으로 사용되는 항생제 내성 유전자 각각에서 분할점을 확인하는 것을 시작하였다. 이중 트랜스제닉 선택의 유효성의 평가를 용이하게 하기 위해, 본 발명자들은 시험 트랜스진으로서 TagBFP2 또는 mCherry 형광 단백질을 발현하는 렌티바이러스 벡터 상에 마커트론을 클로닝하였다 (도 1b). 바이러스 제제를 U2OS 세포로 형질도입한 후, 비-선택 또는 선택 배지를 갖는 복제 플레이트로 분할하였다. 항생제 선택을 위한 적절한 계대배양 후, 2개의 세포 배양물을 유동 세포계측법에 의해 분석하였다. 히그로마이신 (Hygro) 내성 유전자의 경우, 플랭킹 잔기 "GS"를 갖는 하나의 "천연" SspDnaB 분할점 (G200:S201) 및 "YC" 잔기를 갖는 하나의 "천연" NpuDnaE 분할점 (Y89:C90)을 시험하였다. 둘 모두는 N- 및 C-마커트론 둘 모두가 형질도입될 때 성공적인 선택을 가능하게 하였으며, 비-선택된 배양물에서 <10% 이중-양성 세포와 비교하여 선택된 배양물에서 >99% BFP+ mCherry+ 이중 트랜스제닉 세포를 얻었다 (도 3; 플라스미드 쌍 3,4 및 5,6). 2개의 마커트론 중 하나로 형질도입된 세포는 히그로마이신 선택에서 생존하지 않았다. 대조적으로, 통상적인 전장 비-분할 히그로마이신 벡터를 사용한 이중 트랜스제네시스는 BFP+ mCherry+ 세포의 약 20% 풍부만을 허용하였다 (플라스미드 쌍 97,98). 본 발명자들은 C-익스테인 이음부 상의 필수 시스테인 잔기 및 이전 보고서 7에서 실질적인 트랜스-스플라이싱 활성을 지지하는 N-익스테인 이음부 상의 잔기를 갖는 NpuDnaE에 대한 3개의 추가 잠재적인 분할점 (52S:53C), (240A:241C) 및 (292R:293C)를 스크리닝하였다. 또한, 본 발명자들은 추가 분할점을 생성하는 전위성 부위에서 스플라이싱을 지지하기 위해 C-익스테인 이음부 상에 "인공" 시스테인을 삽입함으로써 6개의 추가 NpuDnaE 분할점을 혼입하였다. 전체로서, 시험된 11개의 분할점 중 8개는 히그로마이신 선택을 지지하였다 (도 3). 유사하게, 퓨로마이신 (Puro) (도 4), 네오마이신 (Neo) (도 5) 및 블라스티시딘 (Blast) (도 6) 내성 유전자의 경우, 본 발명자들은 4, 2 및 1개의 기능성 Intres 쌍(들)을 각각 확인하였다. 이들 모든 경우에, 마커트론으로 형질도입된 세포는 선택에서 생존하지 않았으나, 둘 모두로 형질도입된 세포는 블라스티시딘(102) Intres를 제외하고 비-선택 배양물에서 <50%와 비교하여 선택 배양물에서 >95% 이중 트랜스제닉 세포를 수득하였으며, 91% 이중 트랜스제닉 세포의 더 낮지만 여전히 유의하게 풍부함을 달성하였다 (도 3-6). Intres 유전자 및 플라스미드의 분할점의 세부사항은 도 2a-2d 및 표 1에 제공된다.
Figure pct00001
Figure pct00002
Figure pct00003
실시예 2. 게이트웨이-호환가능한 렌티바이러스 벡터
Intres 마커의 채택을 용이하게 하기 위해, 본 발명자들은 트랜스진 8의 편리한 제한-라이게이션-독립적 LR 클로나제 재조합을 위한 게이트웨이-호환가능한 렌티바이러스 벡터를 생성하였다 (도 7a). 본 발명자들은 TagBPF2 및 mCherry를 각각 N- 및 C-Intres 벡터에 재조합함으로써 이들 벡터의 기능성을 시험하였으며, 이중 트랜스제닉 세포의 강건한 선택을 발견하였다 (도 7b). Intres 벡터의 한 잠재적인 유용성은 세포에 상이한 형광 마커를 설치하여 상이한 세포 구획을 표지하는 것이다. 이러한 유용성을 탐색하기 위해, 본 발명자들은 통상적인 전장 (FL) 비-분할 히그로마이신 선택가능한 벡터 또는 2-마커트론 히그로마이신 Intres 벡터 및 플라스미드의 세트로 형질도입된 세포로의 게이트웨이 재조합, 이어서 항생제 선택에 의해, 핵 및 F-액틴을 각각 표지하는 NLS-GFP 및 LifeAct-mScarlet 9에서 클로닝하였다 (도 7c). 비-분할 선택가능한 플라스미드로 형질도입된 샘플은 단일 및 이중 표지된 세포 둘 모두를 함유한 반면, Intres 플라스미드로 형질도입된 세포는 모두 이중 표지되었다 (도 7c).
실시예 3. 형광 마커
분할 형광 마커가 트랜스진 선택을 위해 사용될 수 있는지를 시험하기 위해, 본 발명자들은 mScarlet 형광 단백질에 대한 NpuDnaE 분할점을 스크리닝하고 (도 8a), 4개의 분할점은 이중 트랜스제닉 세포의 >96% 풍부를 허용하고, 3개의 다른 분할점은 비-게이팅된 집단에서 <20% 이중 트랜스제닉 세포와 비교하여 mScarlet-게이팅된 집단에서 이중 트랜스제닉 세포의 >60% 풍부를 가능하게 한다는 것을 확인하였다 (도 8b).
실시예 4. 고도의 분할 마커
본 발명자들은 2-마커트론 Intres 유전자에 대해 확인된 분할점으로 고도의 분할 마커의 조작을 시작하였다. 본 발명자들은 하나의 항생제로 2개 초과의 "비연결된" 트랜스진의 공동선택을 허용하기 위해 마커 유전자를 3개 이상의 마커트론으로 분배하기 위해 분할점의 조합을 시험하였다 (도 9a-9b). 이러한 "Intres 쇄"를 허용하는 분할점의 쌍을 확인하기 위해, 본 발명자들은 3개의 형광 트랜스진 TagBFP2, EGFP 또는 mCherry 중 하나를 각각 보유하는 3개의 렌티바이러스 벡터로 3-분할 마커트론을 클로닝하였으며, 이는 본 발명자들이 유동 세포계측법에 의해 선택의 유효성을 평가하는 것을 가능하게 하였다 (도 9c). 히그로마이신 내성 유전자는 가장 길고, 시험을 위한 가장 큰 분할점을 제공하기 때문에, 본 발명자들은 3-마커트론 히그로마이신 Intres의 조작에 중점을 두었다. 본 발명자들은 2개의 개입 NpuDnaE 인테인을 사용하여 2개의 3-마커트론 히그로마이신 Intres를 시험하였으며, 제1 인테인을 위한 NpuDnaE 및 제2 인테인을 위한 SspDnaB를 사용할 뿐만 아니라 제1 인테인을 위한 SspDnaB 및 제2 인테인을 위한 NpuDnaE를 사용하였다 (도 9d). 비-선택된 배양물에서 <15% 삼중 트랜스제닉 세포와 비교하여, 이들 6개의 3-마커트론 히그로마이신 Intres 중 5개는 >97%를 가능하게 하였고, 나머지 1개는 히그로마이신-선택된 배양물에서 80% 삼중 트랜스제닉 선택을 가능하게 하였다. 리브-원-아웃(leave-one-out) 형질도입을 갖는 샘플은 히그로마이신 선택 후 어떠한 생존가능 세포도 생성하지 않은 반면, 비-분할 히그로마이신 벡터로 형질도입된 세포는 선택 후 오직 7% 삼중 트랜스제닉 세포를 생성하였다.
3-마커트론 Intres의 사용을 용이하게 하기 위해, 본 발명자들은 이들 마커를 갖는 게이트웨이 호환가능한 렌티바이러스 벡터를 생성하였다 (도 10a). TagBFP (트랜스진 1로서), EGFP (트랜스진 2로서) 및 mCherry (트랜스진 3으로서)를 N-, M- 및 C-Intres 게이트웨이 목적지 벡터로 재조합함으로써 이들 벡터의 3개 세트를 각각 시험하였으며, 이를 사용하여 U2OS 세포를 형질도입한 후, 히그로마이신 선택 또는 비-선택 배지에서 분할하고 배양하였다 (도 10b). 선택 후 2주에, 세포를 유동 세포계측법에 의해 분석하였다. 3-마커트론 히그로마이신 Intres 플라스미드의 3개 세트 모두는 비-선택된 배양물에서 <25%와 비교하여 >99%의 삼중 트랜스제닉 세포 선택을 지지하였다 (도 10c).
본 발명자들은 4-마커트론 히그로마이신 Intres 유전자의 타당성을 추가로 시험하였다 (도 11). 여기서, 본 발명자들은 SspDnaB 인테인과 조합하여 류신 지퍼 모티프 11과 융합된 NpuDnaGEP 10으로 공지된 NpuDnaE 인테인의 향상된 변이체를 사용하였다. 구성요소 마커트론을 함유하는 모든 4개의 플라스미드의 형질도입은 히그로마이신 선택에서 생존한 세포를 생성한 반면, 리브-원-아웃 형질도입은 어떠한 생존도 생성하지 않았다 (표 2).
Figure pct00004
실시예 5. AAVS1 유전자좌에서의 이대립유전자 녹-인
CRISPR/Cas는 최근에 게놈 조작 및 편집을 위한 강력한 기술로 부상하였다. NHEJ-매개 삽입/결실 (indel)에 기초한 유전자 녹아웃(knockout)은 높은 빈도로 발생하지만, 외인성 복구 주형 (표적화 구축물이라고도 공지됨)을 사용하는 상동성 지정 복구(homology directed repair)(HDR)에 기초한 정확한 편집 및 녹-인은 비효율적이다. 본 발명자들은 분할 선택가능한 마커가 AAVS1 유전자좌에서 이대립유전자 녹-인을 갖는 세포를 풍부하게 하는데 사용될 수 있는지를 시험하였다. 본 발명자들은 표적 부위를 플랭킹하는 상동성 아암을 갖는 표적화 구축물을 구축하고, 숙주 유전자 PPP1R12C 중 하나인 인트론 내에 마커트론을 포획하기 위해 수용자-2A 펩티드를 스플라이싱하였다. 그러나, 본 발명자들은 이들 표적화 구축물을 사용하는 CRISPR/Cas 녹-인 실험 및 항생제 선택의 2주 후에 어떠한 살아있는 세포도 얻지 못하였다 (데이터는 나타내지 않음). 본 발명자들은 숙주 유전자 PPP1R12C의 내인성 프로모터가 항생제의 작용에 대항하기에 충분한 항생제 내성 단백질을 재구성하기 위해 마커트론의 충분한 발현을 구동할 수 없을 것으로 의심하였다. 그러므로, 본 발명자들은 활성이 독시사이클린 (dox) 농도에 의해 적정될 수 있는 TetO 프로모터에 의해 Intres 마커트론을 발현하는 대안적인 전략을 시험하였다. Intres-매개 이대립유전자 선택 대 전장 (FL) 비-분할 선택가능한 마커의 비교를 허용하기 위해, 본 발명자들은 여러 상이한 표적화 구축물 설계를 구현하였다. 먼저, 본 발명자들은 구성적(constitutive) EF1a 프로모터 하에 rtTA 및 dox-유도성 TetO 프로모터 하에 별도의 시험 Intres (예를 들어, Blast Intres)와 함께 전장 (FL) 내성 유전자 (예를 들어, Hygro)의 발현을 구동하였다 (도 12b, 플라스미드 109 및 110). 이는 동일한 구축물 내에 전장 및 분할 선택가능한 마커의 비교를 허용하였다. 동일한 TetO 프로모터에 의해 구동된 전장 대 분할 마커의 공정한 비교를 허용하기 위해, 본 발명자들은 2개의 유사한 플라스미드 107 및 108 (cf. 플라스미드 109 및 110)을 구축하였으며, 여기서 전장 항생제 내성 유전자 (Blast)는 TetO 프로모터의 하류에 위치하였다 (도 12a). 이대립유전자 표적화의 단일-세포 정량화를 가능하게 하고, 2개의 트랜스진의 2개의 AAVS1 대립유전자로의 혼입의 타당성을 입증하기 위해, 본 발명자들은 자기-절단 2A 펩티드를 통해 시험 분할 또는 비-분할 마커의 하류에 EGFP 및 mScarlet 형광 유전자를 첨부하였다. 유사하게, Hygro Intres를 시험하기 위해, 본 발명자들은 FL Hygro 또는 Hygro Intres는 TetO의 하류에 위치하고 FL Blast는 EF1a의 하류에 위치하도록 EF1a 및 TetO-구동된 마커를 교체하였다 (도 12c-12d; 플라스미드 111-114). 본 발명자들은 Cas9 및 sgRNA 표적화 AAVS1을 함유하는 pX330-AAVS1 (플라스미드 106), 및 표적화 구축물의 상이한 쌍을 HEK293T 세포로 공동-형질감염하고, 이를 후속 계대배양에서 항생제를 갖지 않는, 블라스티시딘을 갖는 또는 히그로마이신을 갖는 삼중 독시사이클린-함유 배지로 분할하였다. 선택 후 2주에, 본 발명자들은 GFP 및 RFP 형광의 유동 세포계측법 측정에 의해 이대립유전자 표적화에 대해 배양물을 분석하였다 (도 12e). 예상된 바와 같이, 비-선택된 배양물은 작은 분율 (<1%)의 이대립유전자 녹-인 GFP+/RFP+ 세포를 보유하였다 (도 12e; 선택 = 없음). 상응하는 FL 항생제 내성 유전자가 표적화 구축물 상에 존재하는 항생제의 선택은 < 30% 이대립유전자 녹-인 세포를 생성하였다 (도 12e; Blast: TC a,c,d; Hygro: TC a,b,c). 대조적으로, 상응하는 Intres가 표적화 구축물 상에 존재하는 항생제의 선택은 75% (도 6e; Blast Intres: TC b) 및 88% (도 6e; Hygro Intres: TC d) 이대립유전자 녹-인 세포를 생성하였다
상기 실시예에서, 본 발명자들은 2개 이상의 "비연결된" 트랜스진에 대한 선택을 허용할 수 있는 분할 항생제 내성 및 형광 단백질 유전자를 조작하였다. 선택가능한 마커에 비자연 잔기를 삽입함으로써, 본 발명자들은 새로운 고효율 분할점을 사용하여 조작에 이용가능한 위치를 확장할 수 있음을 보여주었다. 본 발명자들은 분할 선택가능한 마커가 CRISPR/Cas9 게놈 편집 실험에서 렌티바이러스 벡터 또는 유전자 표적화 구축물로 혼입되어, 이중 트랜스제네시스 또는 이대립유전자 녹-인을 갖는 세포의 풍부를 가능하게 할 수 있다는 것을 입증하였다. 2개 이상의 분할점을 조합함으로써, 본 발명자들은 3- 및 4-분할 마커를 생성하여 고도의 트랜스제닉 선택을 가능하게 할 수 있음을 보여주었다. 훨씬 고도의 분할 선택가능한 마커의 미래 개발은 수십 개의 트랜스진 또는 표적화된 녹-인을 함유하는 세포의 "과조작(hyper-engineering)"을 가능하게 할 수 있다.
재료 및 방법
클로닝
각각의 마커트론을 위한 시험 플라스미드를 생성하기 위해, 본 발명자들은 먼저 그의 ORF를 함유하는 게이트웨이 공여자 플라스미드를 생성한 후, TagBFP2 (플라스미드 94: pLX-DEST-IRES-TagBFP2), EGFP (플라스미드 95: pLX-DEST-IRES-EGFP), 또는 mCherry (플라스미드 96: pLX-DEST-IRES-mCherry) 리포터를 갖는 렌티바이러스 목적지 벡터로 재조합하였으며, 이들은 퓨로마이신 내성 유전자를 제거하고 게이트웨이 카세트의 하류에 IRES-형광 유전자를 삽입함으로써 pLX302 (addgene.org/25896/)로부터 유래된 것이었다. 마커트론-ORF 게이트웨이 공여자 플라스미드는 인테인을, 선택가능한 마커의 단편의 코딩 서열과 조합한 후 서열- 및 라이게이션-독립적 클로닝(sequence- and ligation-independent cloning)(SLIC)에 의해 pCR8-GW-TOPO 플라스미드에 삽입하는 내포 융합 PCR 절차 (Li, M.Z. & Elledge, S.J. SLIC: a method for sequence-and ligation-independent cloning. Gene Synthesis: Methods and Protocols, 51-59 (2012))에 의해, 또는 선택가능한 마커의 관련 단편을 PCR-증폭시킨 후 SLIC에 의해 인테인 서열을 함유하는 "스캐폴드" 플라스미드 (플라스미드 27~32)에 삽입함으로써 생성하였다. 인테인을 코딩하는 DNA 서열을 호모 사피엔스에 대해 코돈 최적화하고, NpuDnaE 인테인을 코딩하는 AC1947GB, SspDnaB 인테인을 코딩하는 AC1949GB와 함께 GBlock (IDT)으로서 합성하였다. 이들 마커를 함유하는 플라스미드로부터 선택가능한 마커 단편을 증폭시켰다. 플라스미드에 대해서는 표 1을 참조한다.
세포 배양
모든 세포를 10% 소 태아 혈청 (FBS)(론자(Lonza)), 4% 글루타맥스(Glutamax) (깁코(Gibco)), 1% 피루브산나트륨 (깁코) 및 페니실린-스트렙토마이신 (깁코)을 갖는 둘베코 변형 이글 배지(Dulbecco's modified Eagle's medium)(DMEM) (시그마(Sigma))에서 배양하였다. 인큐베이터 조건은 37℃ 및 5% CO2였다.
바이러스 생성
pLP1, pLP2 및 VSV-G의 바이러스 패키징 믹스를, 리포펙타민(Lipofectamine) 3000을 사용하여 웰 당 1.2x106개 세포의 농도로 6-웰 플레이트에서 그 전날 접종된 Lenti-X 293T 세포 (클론테크(ClonTech))에 각각의 렌티바이러스 벡터와 함께 공동-형질감염시켰다. 형질감염 후 6시간에 배지를 교체한 다음, 밤새 인큐베이션하였다. 형질감염 후 28시간에 바이러스를 함유하는 배지 상등액을 45 uM PES 필터를 사용하여 여과한 후, 사용할 때까지 -80℃에서 저장하였다.
형질도입
형질도입 전날, 표적 세포 (HEK293T, MCF7, U2-OS)를 웰 당 1.5x105개 세포의 밀도로 12-웰 플레이트에 씨딩하였다. 형질도입 전에, 배지를 웰 당 1 mL의 10 μg/mL 폴리브렌을 함유하는 배지로 교체하였다. 250 μL의 각각의 바이러스 (2종의 바이러스가 첨가된 실험 샘플의 경우 총 500 μL)를 각각의 웰에 첨가하고 밤새 인큐베이션하였다. 감염 후 24시간에 배지를 교체하였다. 감염 후 4일에 세포를 이중 플레이트로 분할하였다. 감염 후 5일에 항생제 (히그로마이신)를 갖는 배지를 하나의 복제 플레이트의 웰 각각에 첨가하였다 (다른 하나는 선택 없이 유지됨). 항생제 선택은 FACS에 의한 분석전 2주 동안 계속하였다.
형광-활성화 세포 분류법
세포를 트립신으로 처리하고, 배지에 현탁시킨 후, HP Z230 워크스테이션에서 FACSDiVa 소프트웨어, 버전 8을 사용하여 LSRFortessa X-20 (비디 바이오사이언스(BD Bioscience)) 유동 세포계측기에서 분석하였다. 각각의 실행에서 5만건의 사건을 수집하였다.
<구축물 및 서열>
Figure pct00005
Figure pct00006
플라스미드 3: pLX-Hygro(1-89)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Hygro(1-89)-NpuDnaE(N)
벡터 서열 (서열식별번호: 20)
아미노산 서열 (서열식별번호: 21)
플라스미드 4: pLX-NpuDnaE(C)-Hygro(90-341)-IRES-mCherry
단백질 = NpuDnaE(C)-Hygro(90-341)
벡터 서열 (서열식별번호: 22)
아미노산 서열 (서열식별번호: 23)
플라스미드 5: pLX-Hygro(1-200)-SspDnaB(N)-IRES-TagBFP2
단백질 = Hygro(1-200)-SspDnaB(N)
벡터 서열 (서열식별번호: 24)
아미노산 서열 (서열식별번호: 25)
플라스미드 6: pLX-SspDnaB(C)-Hygro(201-341)-IRES-mCherry
단백질 = SspDnaB(C)-Hygro(201-341)
벡터 서열 (서열식별번호: 26)
아미노산 서열 (서열식별번호: 27)
플라스미드 7: pLX-Hygro(1-52)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Hygro(1-52)-NpuDnaE(N)
벡터 서열 (서열식별번호: 28)
아미노산 서열 (서열식별번호: 29)
플라스미드 8: pLX-NpuDnaE(C)-Hygro(53-341)-IRES-mCherry
단백질 = NpuDnaE(C)-Hygro(53-341)
벡터 서열 (서열식별번호: 30)
아미노산 서열 (서열식별번호: 31)
플라스미드 9: pLX-Hygro(1-240)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Hygro(1-240)-NpuDnaE(N)
벡터 서열 (서열식별번호: 32)
아미노산 서열 (서열식별번호: 33)
플라스미드 10: pLX-NpuDnaE(C)-Hygro(241-341)-IRES-mCherry
단백질 = NpuDnaE(C)-Hygro(241-341)
벡터 서열 (서열식별번호: 34)
아미노산 서열 (서열식별번호: 35)
플라스미드 11: pLX-Hygro(1-292)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Hygro(1-292)-NpuDnaE(N)
벡터 서열 (서열식별번호: 36)
아미노산 서열 (서열식별번호: 37)
플라스미드 12: pLX-NpuDnaE(C)-Hygro(293-341)-IRES-mCherry
단백질 = NpuDnaE(C)-Hygro(293-341)
벡터 서열 (서열식별번호: 38)
아미노산 서열 (서열식별번호: 39)
플라스미드 13: pLX-Blast(1-102)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Blast(1-102)-NpuDnaE(N)
벡터 서열 (서열식별번호: 40)
아미노산 서열 (서열식별번호: 41)
플라스미드 14: pLX-NpuDnaE(C)-Blast(103-140)-IRES-mCherry
단백질 = NpuDnaE(C)-Blast(103-140)
벡터 서열 (서열식별번호: 42)
아미노산 서열 (서열식별번호: 43)
플라스미드 17: pLX-Puro(1-119)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Puro(1-119)-NpuDnaE(N)
벡터 서열 (서열식별번호: 44)
아미노산 서열 (서열식별번호: 45)
플라스미드 18: pLX-NpuDnaE(C)-Puro(insCys;120-199)-IRES-mCherry
단백질 = NpuDnaE(C)-Puro(insCys;120-199)
벡터 서열 (서열식별번호: 46)
아미노산 서열 (서열식별번호: 47)
플라스미드 19: pLX-Puro(1-100)-SspDnaB(N-S0)-IRES-TagBFP2
단백질 = Puro(1-100)-SspDnaB(N-S0)
벡터 서열 (서열식별번호: 48)
아미노산 서열 (서열식별번호: 49)
플라스미드 20: pLX-SspDnaB(C-S0)-Puro(101-199)-IRES-mCherry
단백질 = SspDnaB(C-S0)-Puro(101-199)
벡터 서열 (서열식별번호: 50)
아미노산 서열 (서열식별번호: 51)
플라스미드 21: pLX-Neo(1-133)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Neo(1-133)-NpuDnaE(N)
벡터 서열 (서열식별번호: 52)
아미노산 서열 (서열식별번호: 53)
플라스미드 22: pLX-NpuDnaE(C)-Neo(134-267)-IRES-mCherry
단백질 = NpuDnaE(C)-Neo(134-267)
벡터 서열 (서열식별번호: 54)
아미노산 서열 (서열식별번호: 55)
플라스미드 23: pLX-Neo(1-194)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Neo(1-194)-NpuDnaE(N)
벡터 서열 (서열식별번호: 56)
아미노산 서열 (서열식별번호: 57)
플라스미드 24: pLX-NpuDnaE(C)-Neo(195-267)-IRES-mCherry
단백질 = NpuDnaE(C)-Neo(195-267)
벡터 서열 (서열식별번호: 58)
아미노산 서열 (서열식별번호: 59)
플라스미드 25: pLX-NpuDnaE(C)_Hygro(53-89)-NpuDnaE(N)-IRES-GFP
단백질 = NpuDnaE(C)_Hygro(53-89)-NpuDnaE(N)
벡터 서열 (서열식별번호: 60)
아미노산 서열 (서열식별번호: 61)
플라스미드 26: pLX-NpuDnaE(C)_Hygro(53-239)-NpuDnaE(N)-IRES-GFP
단백질 = NpuDnaE(C)_Hygro(53-239)-NpuDnaE(N)
벡터 서열 (서열식별번호: 62)
아미노산 서열 (서열식별번호: 63)
플라스미드 27: pCR8-BsaI->ccdbCam<-BsaI-NpuDnaE(N)-MD1-68-15 (서열식별번호: 64)
플라스미드 28: pCR8-NpuDnaE(C)_BsaI->ccdbCam<-BsaI-MD1-68-18 (서열식별번호: 65)
플라스미드 29: pCR8-BsaI->ccdbCam<-BsaI-SspDnaE(N)-MD1-68-12 (서열식별번호: 66)
플라스미드 30: pCR8-SspDnaE(C)_BsaI->ccdbCam<-BsaI-MD1-68-13 (서열식별번호: 67)
플라스미드 31: pCR8-BsaI->ccdbCam<-BsaI-SspDnaB(N-S0)-25-135-18 (서열식별번호: 68)
플라스미드 32: pCR8-SspDnaB(C-S0)_BsaI->ccdbCam<-BsaI-25-155-41 (서열식별번호: 69)
플라스미드 33: pLX-mScarlet(1-46)-NpuDnaE(N)_LZA-IRES-TagBFP2
단백질 = mScarlet(1-46)-NpuDnaE(N)_LZA
벡터 서열 (서열식별번호: 70)
아미노산 서열 (서열식별번호: 71)
플라스미드 34: pLX-LZB_NpuDnaE(C)-mScarlet(insCys;47-232)-IRES-TagBFP2
단백질 = LZB_NpuDnaE(C)-mScarlet(insCys;47-232)
벡터 서열 (서열식별번호: 72)
아미노산 서열 (서열식별번호: 73)
플라스미드 35: pLX-mScarlet(1-48)-NpuDnaE(N)_LZA-IRES-TagBFP2
단백질 = mScarlet(1-48)-NpuDnaE(N)_LZA
벡터 서열 (서열식별번호: 74)
아미노산 서열 (서열식별번호: 75)
플라스미드 36: pLX-LZB_NpuDnaE(C)-mScarlet(insCys;49-232)-IRES-GFP
단백질 = LZB_NpuDnaE(C)-mScarlet(insCys;49-232)
벡터 서열 (서열식별번호: 76)
아미노산 서열 (서열식별번호: 77)
플라스미드 37: pLX-mScarlet(1-51)-NpuDnaE(N)_LZA -IRES-TagBFP2
단백질 = mScarlet(1-51)-NpuDnaE(N)_LZA
벡터 서열 (서열식별번호: 78)
아미노산 서열 (서열식별번호: 79)
플라스미드 38: pLX-LZB_NpuDnaE(C)-mScarlet(insCys;52-232)-IRES-GFP
단백질 = LZB_NpuDnaE(C)-mScarlet(insCys;52-232)
벡터 서열 (서열식별번호: 80)
아미노산 서열 (서열식별번호: 81)
플라스미드 39: pLX-mScarlet(1-75)-NpuDnaE(N)_LZA-IRES-TagBFP2
단백질 = mScarlet(1-75)-NpuDnaE(N)_LZA
벡터 서열 (서열식별번호: 82)
아미노산 서열 (서열식별번호: 83)
플라스미드 40: pLX-LZB_NpuDnaE(C)-mScarlet(insCys;76-232)-IRES-GFP
단백질 = LZB_NpuDnaE(C)-mScarlet(insCys;76-232)
벡터 서열 (서열식별번호: 84)
아미노산 서열 (서열식별번호: 85)
플라스미드 41: pLX-mScarlet(1-122)-NpuDnaE(N)_LZA-IRES-TagBFP2
단백질 = mScarlet(1-122)-NpuDnaE(N)_LZA
벡터 서열 (서열식별번호: 86)
아미노산 서열 (서열식별번호: 87)
플라스미드 42: pLX-LZB_NpuDnaE(C)-mScarlet(insCys;123-232)-IRES-GFP
단백질 = LZB_NpuDnaE(C)-mScarlet(insCys;123-232)
벡터 서열 (서열식별번호: 88)
아미노산 서열 (서열식별번호: 89)
플라스미드 43: pLX-mScarlet(1-140)-NpuDnaE(N)_LZA-IRES-TagBFP2
단백질 = mScarlet(1-140)-NpuDnaE(N)_LZA
벡터 서열 (서열식별번호: 90)
아미노산 서열 (서열식별번호: 91)
플라스미드 44: pLX-LZB_NpuDnaE(C)-mScarlet(insCys;141-232)-IRES-GFP
단백질 = LZB_NpuDnaE(C)-mScarlet(insCys;141-232)
벡터 서열 (서열식별번호: 92)
아미노산 서열 (서열식별번호: 93)
플라스미드 45: pLX-mScarlet(1-163)-NpuDnaE(N)_LZA-IRES-TagBFP2
단백질 = mScarlet(1-163)-NpuDnaE(N)_LZA
벡터 서열 (서열식별번호: 94)
아미노산 서열 (서열식별번호: 95)
플라스미드 46: pLX-LZB_NpuDnaE(C)-mScarlet(insCys;164-232)-IRES-GFP
단백질 = LZB_NpuDnaE(C)-mScarlet(insCys;164-232)
벡터 서열 (서열식별번호: 96)
아미노산 서열 (서열식별번호: 97)
플라스미드 47: pCR8-TagBFP2
단백질 = TagBFP2
벡터 서열 (서열식별번호: 98)
아미노산 서열 (서열식별번호: 99)
플라스미드 48: pCR8-mCherry
단백질 = mCherry
벡터 서열 (서열식별번호: 100)
아미노산 서열 (서열식별번호: 101)
플라스미드 49: pLX-DEST-IRES-Hygro(1-89)-NpuDnaE(N)
단백질 = Hygro(1-89)-NpuDnaE(N)
벡터 서열 (서열식별번호: 102)
아미노산 서열 (서열식별번호: 103)
플라스미드 50: pLX-DEST-IRES-NpuDnaE(C)-Hygro(90-341)
단백질 = NpuDnaE(C)-Hygro(90-341)
벡터 서열 (서열식별번호: 104)
아미노산 서열 (서열식별번호: 105)
플라스미드 51: pLX-[TagBFP2]-IRES-Hygro(1-89)-NpuDnaE(N)
벡터 서열 (서열식별번호: 106)
플라스미드 52: pLX-[mCherry]-IRES-NpuDnaE(C)-Hygro(90-341)
벡터 서열 (서열식별번호: 107)
플라스미드 53: pLX-DEST-IRES-Puro(1-119)-NpuDnaE(N)
단백질 = Puro(1-119)-NpuDnaE(N)
벡터 서열 (서열식별번호: 108)
아미노산 서열 (서열식별번호: 109)
플라스미드 54: pLX-DEST-IRES-NpuDnaE(C)-Puro(120-199)
단백질 = NpuDnaE(C)-Puro(120-199)
벡터 서열 (서열식별번호: 110)
아미노산 서열 (서열식별번호: 111)
플라스미드 55: pLX-[TagBFP2]-IRES-Puro(1-119)-NpuDnaE(N)
벡터 서열 (서열식별번호: 112)
플라스미드 56: pLX-[mCherry]-IRES-NpuDnaE(C)-Puro(120-199)
벡터 서열 (서열식별번호: 113)
플라스미드 57: pLX-DEST-IRES-Neo(1-194)-NpuDnaE(N)
단백질 = Neo(1-194)-NpuDnaE(N)
벡터 서열 (서열식별번호: 114)
아미노산 서열 (서열식별번호: 115)
플라스미드 58: pLX-DEST-IRES-NpuDnaE(C)-Neo(195-267)
단백질 = NpuDnaE(C)-Neo(195-267)
벡터 서열 (서열식별번호: 116)
아미노산 서열 (서열식별번호: 117)
플라스미드 59: pLX-[TagBFP2]-IRES-Neo(1-194)-NpuDnaE(N)
벡터 서열 (서열식별번호: 118)
플라스미드 60: pLX-[mCherry]-IRES-NpuDnaE(C)-Neo(195-267)
벡터 서열 (서열식별번호: 119)
플라스미드 61: pLX-mScarlet(1-51)-NpuDnaE(N)-LZA-IRES-TagBFP2
단백질 = mScarlet(1-51)-NpuDnaE(N)-LZA
벡터 서열 (서열식별번호: 120)
아미노산 서열 (서열식별번호: 121)
플라스미드 62: pLX-LZB-NpuDnaE(C)-mScarlet(^C,52-163)-NpuDnaE(N)_LZA-IRES-EGFP
단백질 = LZB-NpuDnaE(C)-mScarlet(^C;52-163)-NpuDnaE(N)_LZA
벡터 서열 (서열식별번호: 122)
아미노산 서열 (서열식별번호: 123)
플라스미드 63: pLX-LZB-NpuDnaE(C)-mScarlet(^C;164-232)-IRES-EGFP
단백질 = LZB-NpuDnaE(C)-mScarlet(^C;164-232)
벡터 서열 (서열식별번호: 124)
아미노산 서열 (서열식별번호: 125)
플라스미드 64: pLX-Hygro(1-69)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Hygro(1-69)-NpuDnaE(N)
벡터 서열 (서열식별번호: 126)
아미노산 서열 (서열식별번호: 127)
플라스미드 65: pLX-NpuDnaE(C)-Hygro(^C;70-341)-IRES-mCherry
단백질 = NpuDnaE(C)-Hygro(^C;70-341)
벡터 서열 (서열식별번호: 128)
아미노산 서열 (서열식별번호: 129)
플라스미드 66: pLX-Hygro(1-131)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Hygro(1-131)-NpuDnaE(N)
벡터 서열 (서열식별번호: 130)
아미노산 서열 (서열식별번호: 131)
플라스미드 67: pLX-NpuDnaE(C)-Hygro(^C;132-341)-IRES-mCherry
단백질 = NpuDnaE(C)-Hygro(^C;132-341)
벡터 서열 (서열식별번호: 132)
아미노산 서열 (서열식별번호: 133)
플라스미드 68: pLX-Hygro(1-171)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Hygro(1-171)-NpuDnaE(N)
벡터 서열 (서열식별번호: 134)
아미노산 서열 (서열식별번호: 135)
플라스미드 69: pLX-NpuDnaE(C)-Hygro(^C;172-341)-IRES-mCherry
단백질 = NpuDnaE(C)-Hygro(^C;172-341)
벡터 서열 (서열식별번호: 136)
아미노산 서열 (서열식별번호: 137)
플라스미드 70: pLX-Hygro(1-218)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Hygro(1-218)-NpuDnaE(N)
벡터 서열 (서열식별번호: 138)
아미노산 서열 (서열식별번호: 139)
플라스미드 71: pLX-NpuDnaE(C)-Hygro(^C;219-341)-IRES-mCherry
단백질 = NpuDnaE(C)-Hygro(^C;219-341)
벡터 서열 (서열식별번호: 140)
아미노산 서열 (서열식별번호: 141)
플라스미드 72: pLX-Hygro(1-259)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Hygro(1-259)-NpuDnaE(N)
벡터 서열 (서열식별번호: 142)
아미노산 서열 (서열식별번호: 143)
플라스미드 73: pLX-NpuDnaE(C)-Hygro(^C;260-341)-IRES-mCherry
단백질 = NpuDnaE(C)-Hygro(^C;260-341)
벡터 서열 (서열식별번호: 144)
아미노산 서열 (서열식별번호: 145)
플라스미드 74: pLX-Hygro(1-277)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Hygro(1-277)-NpuDnaE(N)
벡터 서열 (서열식별번호: 146)
아미노산 서열 (서열식별번호: 147)
플라스미드 75: pLX-NpuDnaE(C)-Hygro(^C; 278-341)-IRES-mCherry
단백질 = NpuDnaE(C)-Hygro(^C;278-341)
벡터 서열 (서열식별번호: 148)
아미노산 서열 (서열식별번호: 149)
플라스미드 76: pLX-Puro(1-32)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Puro(1-32)-NpuDnaE(N)
벡터 서열 (서열식별번호: 150)
아미노산 서열 (서열식별번호: 151)
플라스미드 77: pLX-NpuDnaE(C)-Puro(^C;33-199)-IRES-mCherry
단백질 = NpuDnaE(C)-Puro(^C;33-199)
벡터 서열 (서열식별번호: 152)
아미노산 서열 (서열식별번호: 153)
플라스미드 78: pLX-Puro(1-84)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Puro(1-84)-NpuDnaE(N)
벡터 서열 (서열식별번호: 154)
아미노산 서열 (서열식별번호: 155)
플라스미드 79: pLX-NpuDnaE(C)-Puro(^C;85-199)-IRES-mCherry
단백질 = NpuDnaE(C)-Puro(^C;85-199)
벡터 서열 (서열식별번호: 156)
아미노산 서열 (서열식별번호: 157)
플라스미드 80: pLX-Puro(1-137)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Puro(1-137)-NpuDnaE(N)
파일 = pLX-[PuroKC3(N)-NpuDnaE(N)-25-131-29"]-IRES-TagBFP2-25-133-6
벡터 서열 (서열식별번호: 158)
아미노산 서열 (서열식별번호: 159)
플라스미드 81: pLX-NpuDnaE(C)-Puro(^C;138-199)-IRES-mCherry
단백질 = NpuDnaE(C)-Puro(^C;138-199)
벡터 서열 (서열식별번호: 160)
아미노산 서열 (서열식별번호: 161)
플라스미드 82: pLX-Puro(1-158)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Puro(1-158)-NpuDnaE(N)
벡터 서열 (서열식별번호: 162)
아미노산 서열 (서열식별번호: 163)
플라스미드 83: pLX-NpuDnaE(C)-Puro(^C;159-199)-IRES-mCherry
단백질 = NpuDnaE(C)-Puro(^C;159-199)
벡터 서열 (서열식별번호: 164)
아미노산 서열 (서열식별번호: 165)
플라스미드 84: pLX-Puro(1-180)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Puro(1-180)-NpuDnaE(N)
벡터 서열 (서열식별번호: 166)
아미노산 서열 (서열식별번호: 167)
플라스미드 85: pLX-NpuDnaE(C)-Puro(^C;181-199)-IRES-mCherry
단백질 = NpuDnaE(C)-Puro(^C;181-199)
벡터 서열 (서열식별번호: 168)
아미노산 서열 (서열식별번호: 169)
플라스미드 86: pLX-Blast(1-58)-NpuDnaE(N)-IRES-TagBFP2
단백질 = Blast(1-58)-NpuDnaE(N)
벡터 서열 (서열식별번호: 170)
아미노산 서열 (서열식별번호: 171)
플라스미드 87: pLX-NpuDnaE(C)-Blast(59-140)-IRES-mCherry
단백질 = NpuDnaE(C)-Blast(59-140)
벡터 서열 (서열식별번호: 172)
아미노산 서열 (서열식별번호: 173)
플라스미드 88: pLX-NpuDnaE(C)-HygroBA-SspDnaB(N-S0)-IRES-EGFP
단백질 = NpuDnaE(C)-Hygro(53-200)-SspDnaB(N-S0)
벡터 서열 (서열식별번호: 174)
아미노산 서열 (서열식별번호: 175)
플라스미드 89: pLX-SspDnaB(C-S0)-Hygro(201-341)-IRES-mCherry
단백질 = SspDnaB(C-S0)-Hygro(201-341)
벡터 서열 (서열식별번호: 176)
아미노산 서열 (서열식별번호: 177)
플라스미드 90: pLX-NpuDnaE(C)-Hygro(90-200)-SspDnaB(N-S0)-IRES-EGFP
단백질 = NpuDnaE(C)-Hygro(90-200)-SspDnaB(N-S0)
벡터 서열 (서열식별번호: 178)
아미노산 서열 (서열식별번호: 179)
플라스미드 91: pLX-Hygro(1-200)-SspDnaB(N-S0)-IRES-TagBFP2
단백질 = Hygro(1-200)-SspDnaB(N-S0)
벡터 서열 (서열식별번호: 180)
아미노산 서열 (서열식별번호: 181)
플라스미드 92: pLX-SspDnaB(C-S0)-Hygro(201-240)-NpuDnaE(N)-IRES-EGFP
단백질 = SspDnaB(C-S0)-Hygro(201-240)-NpuDnaE(N)
벡터 서열 (서열식별번호: 182)
아미노산 서열 (서열식별번호: 183)
플라스미드 93: pLX-SspDnaB(C-S0)-Hygro(201-292)-NpuDnaE(N)-IRES-EGFP
단백질 = SspDnaB(C-S0)-Hygro(201-292)-NpuDnaE(N)
벡터 서열 (서열식별번호: 184)
아미노산 서열 (서열식별번호: 185)
플라스미드 94: pLX-DEST-IRES-TagBFP2 (서열식별번호: 186)
플라스미드 95: pLX-DEST-IRES-EGFP (서열식별번호: 187)
플라스미드 96: pLX-DEST-IRES-mCherry (서열식별번호: 188)
플라스미드 97: pLX-Hygro-IRES-TagBFP2
벡터 서열 (서열식별번호: 189)
플라스미드 98: pLX-Hygro-IRES-mCherry
벡터 서열 (서열식별번호: 190)
플라스미드 99: pLX-Puro-IRES-TagBFP2
벡터 서열 (서열식별번호: 191)
플라스미드 100: pLX-Puro-IRES-mCherry
벡터 서열 (서열식별번호: 192)
플라스미드 101: pLX-Hygro-IRES-EGFP
벡터 서열 (서열식별번호: 193)
플라스미드 102: pLX-NLS_GFP-IRES-Hygro
벡터 서열 (서열식별번호: 194)
플라스미드 103: pLX-LifeAct_mCherry-IRES-Hygro
벡터 서열 (서열식별번호: 195)
플라스미드 104: pLX-NLS_GFP-IRES-Hygro(1-89)-NpuDnaE(N)
벡터 서열 (서열식별번호: 196)
플라스미드 105: pLX-LifeAct_mScarlet-IRES- NpuDnaE(C)-Hygro(90-341)
벡터 서열 (서열식별번호: 197)
플라스미드 106: pX330-AAVS1
sgRNA 스페이서 서열: gACCCCACAGTGGGGCCACTA (첫 번째 g는 게놈과 매칭하지 않음) (서열식별번호: 198)
벡터 서열 (서열식별번호: 199)
플라스미드 107: pAAVS1-Nst-EF1aHygro2ArtTA3(-)_TetO-Blast-P2A-EGFP
벡터 서열 (서열식별번호: 200)
플라스미드 108: pAAVS1-Nst-EF1aHygro2ArtTA3(-)_TetO-Blast-P2A-mScarlet
벡터 서열 (서열식별번호: 201)
플라스미드 109: pAAVS1-Nst-EF1aHygro2ArtTA3(-)_TetO-Blast(1-102)_NpuDnaE(N)-P2A-EGFP
벡터 서열 (서열식별번호: 202)
플라스미드 110: pAAVS1-Nst-EF1aHygro2ArtTA3(-)_TetO-NpuDnaE(C)_Blast(103-140)-P2A-mScarlet
벡터 서열 (서열식별번호: 203)
플라스미드 111: pAAVS1-Nst-EF1aBlast2ArtTA3(-)_TetO-Hygro-P2A-NTR-E2A-EGFP
벡터 서열 (서열식별번호: 204)
플라스미드 112: pAAVS1-Nst-EF1aBlast2ArtTA3(-)_TetO-Hygro-P2A-NTR-E2A-mCherry
벡터 서열 (서열식별번호: 205)
플라스미드 113: pAAVS1-Nst-EF1aBlast2ArtTA3(-)_TetO- Hygro(1-89)-NpuDnaE(N)-P2A-NTR-E2A-EGFP
벡터 서열 (서열식별번호: 206)
플라스미드 114: pAAVS1-Nst-EF1aBlast2ArtTA3(-)_TetO- NpuDnaE(C)-Hygro(90-341)-P2A-NTR-E2A-mCherry
벡터 서열 (서열식별번호: 207)
플라스미드 115: pLX-Hygro(1-89)_NpuDnaE(N)_LZA-IRES-TagBFP2
단백질 = Hygro(1-89)-NpuDnaE(N)-LZA
벡터 서열 (서열식별번호: 208)
아미노산 서열 (서열식별번호: 209)
플라스미드 116: pLX-LZB_NpuDnaGEP(C)_Hygro(90-200)_SspDnaB(N-S0)-IRES-GFP
단백질 = LZB-NpuDnaGEP(C)-Hygro(90-200)-SspDnaB(N-S0)
벡터 서열 (서열식별번호: 210)
아미노산 서열 (서열식별번호: 211)
플라스미드 117: pLX-SspDnaB(C-S0)_Hygro(201-240)_NpuDnaE(N)_LZA-IRES-GFP
단백질 = SspDnaB(C-S0)-Hygro(201-240)-NpuDnaE(N)-LZA
벡터 서열 (서열식별번호: 212)
아미노산 서열 (서열식별번호: 213)
플라스미드 118: pLX-LZB_NpuDnaGEP(C)_Hygro(241-341)-IRES-mCherry
단백질 = LZB-NpuDnaGEP(C)-Hygro(241-341)
벡터 서열 (서열식별번호: 214)
아미노산 서열 (서열식별번호: 215)
AC1947GB (서열식별번호: 216)
AC1949GB (서열식별번호: 217)
pCR8-ccdbCam (서열식별번호: 218)
참고문헌
Figure pct00007
본원에 개시된 모든 참고문헌, 특허 및 특허 출원은 각각이 인용되는 주제와 관련하여 참조로 포함되며, 일부 경우에 문헌의 전체를 포함할 수 있다.
본원의 명세서 및 청구범위에서 사용된 단수 형태는 달리 명백하게 지시되지 않는 한, "적어도 하나"를 의미하는 것으로 이해되어야 한다.
또한, 달리 명백하게 지시되지 않는 한, 하나 초과의 단계 또는 작용을 포함하는 본원에 청구된 임의의 방법에서, 방법의 단계 또는 작용의 순서는 방법의 단계 또는 작용이 인용된 순서로 반드시 제한되는 것은 아니라는 것이 이해되어야 한다.
상기 명세서 뿐만 아니라 청구범위에서, 모든 연결구, 예컨대 "포함하는(comprising)", "포함하는(including)", "보유하는" "갖는", "함유하는", "수반하는", "유지하는", "로 구성되는(composed of)" 등은 개방형, 즉 포함하나 이에 제한되지는 않는 것을 의미하는 것으로 이해되어야 한다. 연결구 "로 이루어진" 및 "로 본질적으로 이루어진"만이 미국 특허청 특허 심사 절차 매뉴얼, 섹션 2111.03에 기술된 바와 같이 각각 폐쇄형 또는 반-폐쇄형 연결구이다.
수치 앞의 용어 "약" 및 "실질적으로"는 인용된 수치의 ±10%를 의미한다.
값의 범위가 제공되는 경우, 범위의 상단 및 하단 사이의 각각의 값은 본원에서 구체적으로 고려되고 설명된다.
SEQUENCE LISTING <110> The Jackson Laboratory <120> TRANSGENIC SELECTION METHODS AND COMPOSITIONS <130> J0227.70007WO00 <140> Not Yet Assigned <141> Concurrently Herewith <150> US 62/624,629 <151> 2018-01-31 <150> US 62/616,281 <151> 2018-01-11 <150> US 62/608,478 <151> 2017-12-20 <150> US 62/571,672 <151> 2017-10-12 <160> 218 <170> PatentIn version 3.5 <210> 1 <211> 341 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 1 Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe Leu Ile 1 5 10 15 Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 20 25 30 Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 35 40 45 Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 50 55 60 Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 65 70 75 80 Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala Gln 85 90 95 Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu 100 105 110 Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser 115 120 125 Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr 130 135 140 Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr 145 150 155 160 His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln 165 170 175 Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg 180 185 190 His Leu Val His Ala Asp Phe Gly Ser Asn Asn Val Leu Thr Asp Asn 195 200 205 Gly Arg Ile Thr Ala Val Ile Asp Trp Ser Glu Ala Met Phe Gly Asp 210 215 220 Ser Gln Tyr Glu Val Ala Asn Ile Phe Phe Trp Arg Pro Trp Leu Ala 225 230 235 240 Cys Met Glu Gln Gln Thr Arg Tyr Phe Glu Arg Arg His Pro Glu Leu 245 250 255 Ala Gly Ser Pro Arg Leu Arg Ala Tyr Met Leu Arg Ile Gly Leu Asp 260 265 270 Gln Leu Tyr Gln Ser Leu Val Asp Gly Asn Phe Asp Asp Ala Ala Trp 275 280 285 Ala Gln Gly Arg Cys Asp Ala Ile Val Arg Ser Gly Ala Gly Thr Val 290 295 300 Gly Arg Thr Gln Ile Ala Arg Arg Ser Ala Ala Val Trp Thr Asp Gly 305 310 315 320 Cys Val Glu Val Leu Ala Asp Ser Gly Asn Arg Arg Pro Ser Thr Arg 325 330 335 Pro Arg Ala Lys Glu 340 <210> 2 <211> 199 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 2 Met Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp Asp Val 1 5 10 15 Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr Pro Ala 20 25 30 Thr Arg His Thr Val Asp Pro Asp Arg His Ile Glu Arg Val Thr Glu 35 40 45 Leu Gln Glu Leu Phe Leu Thr Arg Val Gly Leu Asp Ile Gly Lys Val 50 55 60 Trp Val Ala Asp Asp Gly Ala Ala Val Ala Val Trp Thr Thr Pro Glu 65 70 75 80 Ser Val Glu Ala Gly Ala Val Phe Ala Glu Ile Gly Pro Arg Met Ala 85 90 95 Glu Leu Ser Gly Ser Arg Leu Ala Ala Gln Gln Gln Met Glu Gly Leu 100 105 110 Leu Ala Pro His Arg Pro Lys Glu Pro Ala Trp Phe Leu Ala Thr Val 115 120 125 Gly Val Ser Pro Asp His Gln Gly Lys Gly Leu Gly Ser Ala Val Val 130 135 140 Leu Pro Gly Val Glu Ala Ala Glu Arg Ala Gly Val Pro Ala Phe Leu 145 150 155 160 Glu Thr Ser Ala Pro Arg Asn Leu Pro Phe Tyr Glu Arg Leu Gly Phe 165 170 175 Thr Val Thr Ala Asp Val Glu Val Pro Glu Gly Pro Arg Thr Trp Cys 180 185 190 Met Thr Arg Lys Pro Gly Ala 195 <210> 3 <211> 264 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 3 Met Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala Ala Trp Val 1 5 10 15 Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile Gly Cys Ser 20 25 30 Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro Val Leu Phe 35 40 45 Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln Asp Glu Ala 50 55 60 Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys Ala Ala Val 65 70 75 80 Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu Leu Gly Glu 85 90 95 Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro Ala Glu Lys 100 105 110 Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr Leu Asp Pro 115 120 125 Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile Glu Arg Ala 130 135 140 Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp Leu Asp Glu 145 150 155 160 Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg Leu Lys Ala 165 170 175 Arg Met Pro Asp Gly Glu Asp Leu Val Val Thr His Gly Asp Ala Cys 180 185 190 Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe Ser Gly Phe Ile Asp 195 200 205 Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln Asp Ile Ala Leu Ala 210 215 220 Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu Trp Ala Asp Arg Phe 225 230 235 240 Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser Gln Arg Ile Ala Phe 245 250 255 Tyr Arg Leu Leu Asp Glu Phe Phe 260 <210> 4 <211> 140 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 4 Met Lys Thr Phe Asn Ile Ser Gln Gln Asp Leu Glu Leu Val Glu Val 1 5 10 15 Ala Thr Glu Lys Ile Thr Met Leu Tyr Glu Asp Asn Lys His His Val 20 25 30 Gly Ala Ala Ile Arg Thr Lys Thr Gly Glu Ile Ile Ser Ala Val His 35 40 45 Ile Glu Ala Tyr Ile Gly Arg Val Thr Val Cys Ala Glu Ala Ile Ala 50 55 60 Ile Gly Ser Ala Val Ser Asn Gly Gln Lys Asp Phe Asp Thr Ile Val 65 70 75 80 Ala Val Arg His Pro Tyr Ser Asp Glu Val Asp Arg Ser Ile Arg Val 85 90 95 Val Ser Pro Cys Gly Met Cys Arg Glu Leu Ile Ser Asp Tyr Ala Pro 100 105 110 Asp Cys Phe Val Leu Ile Glu Met Asn Gly Lys Leu Val Lys Thr Thr 115 120 125 Ile Glu Glu Leu Ile Pro Leu Lys Tyr Thr Arg Asn 130 135 140 <210> 5 <211> 239 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 5 Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 1 5 10 15 Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 20 25 30 Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 35 40 45 Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 50 55 60 Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 65 70 75 80 Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 85 90 95 Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 100 105 110 Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 115 120 125 Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 130 135 140 Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 145 150 155 160 Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 165 170 175 Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 180 185 190 Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 195 200 205 Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 210 215 220 Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 225 230 235 <210> 6 <211> 232 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 6 Met Val Ser Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys 1 5 10 15 Val His Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 20 25 30 Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 35 40 45 Val Thr Lys Gly Gly Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro 50 55 60 Gln Phe Met Tyr Gly Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile 65 70 75 80 Pro Asp Tyr Tyr Lys Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 85 90 95 Val Met Asn Phe Glu Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr 100 105 110 Ser Leu Glu Asp Gly Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr 115 120 125 Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 130 135 140 Glu Ala Ser Thr Glu Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly 145 150 155 160 Asp Ile Lys Met Ala Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu Ala 165 170 175 Asp Phe Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Met Pro Gly 180 185 190 Ala Tyr Asn Val Asp Arg Lys Leu Asp Ile Thr Ser His Asn Glu Asp 195 200 205 Tyr Thr Val Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His Ser Thr 210 215 220 Gly Gly Met Asp Glu Leu Tyr Lys 225 230 <210> 7 <211> 102 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 7 Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu 1 5 10 15 Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 20 25 30 Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 35 40 45 Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 50 55 60 Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 65 70 75 80 Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 85 90 95 Val Asp Asn Leu Pro Asn 100 <210> 8 <211> 35 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 8 Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr Asp 1 5 10 15 Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe Ile 20 25 30 Ala Ser Asn 35 <210> 9 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 9 Cys Ile Ser Gly Asp Ser Leu Ile Ser Leu Ala Ser Thr Gly Lys Arg 1 5 10 15 Val Ser Ile Lys Asp Leu Leu Asp Glu Lys Asp Phe Glu Ile Trp Ala 20 25 30 Ile Asn Glu Gln Thr Met Lys Leu Glu Ser Ala Lys Val Ser Arg Val 35 40 45 Phe Cys Thr Gly Lys Lys Leu Val Tyr Ile Leu Lys Thr Arg Leu Gly 50 55 60 Arg Thr Ile Lys Ala Thr Ala Asn His Arg Phe Leu Thr Ile Asp Gly 65 70 75 80 Trp Lys Arg Leu Asp Glu Leu Ser Leu Lys Glu His Ile Ala Leu Pro 85 90 95 Arg Lys Leu Glu Ser Ser Ser Leu Gln Leu 100 105 <210> 10 <211> 48 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 10 Ser Pro Glu Ile Glu Lys Leu Ser Gln Ser Asp Ile Tyr Trp Asp Ser 1 5 10 15 Ile Val Ser Ile Thr Glu Thr Gly Val Glu Glu Val Phe Asp Leu Thr 20 25 30 Val Pro Gly Pro His Asn Phe Val Ala Asn Asp Ile Ile Val His Asn 35 40 45 <210> 11 <211> 139 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 11 Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu 1 5 10 15 Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 20 25 30 Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 35 40 45 Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 50 55 60 Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 65 70 75 80 Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 85 90 95 Val Asp Asn Leu Pro Asn Gly Gly Gly Gly Ser Gly Ser Ala Gln Leu 100 105 110 Glu Lys Glu Leu Gln Ala Leu Glu Lys Lys Leu Ala Gln Leu Glu Trp 115 120 125 Glu Asn Gln Ala Leu Glu Lys Glu Leu Ala Gln 130 135 <210> 12 <211> 68 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 12 Ala Gln Leu Lys Lys Lys Leu Gln Ala Asn Lys Lys Glu Leu Ala Gln 1 5 10 15 Leu Lys Trp Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln Gly Gly 20 25 30 Gly Gly Ser Gly Ser Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly 35 40 45 Lys Gln Asn Val Tyr Asp Ile Gly Val Gly Glu Pro His Asn Phe Ala 50 55 60 Leu Lys Asn Gly 65 <210> 13 <211> 35 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 13 Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr Asp 1 5 10 15 Ile Gly Val Gly Glu Pro His Asn Phe Ala Leu Lys Asn Gly Phe Ile 20 25 30 Ala Ser Asn 35 <210> 14 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 14 Ala Gln Leu Glu Lys Glu Leu Gln Ala Leu Glu Lys Lys Leu Ala Gln 1 5 10 15 Leu Glu Trp Glu Asn Gln Ala Leu Glu Lys Glu Leu Ala Gln 20 25 30 <210> 15 <211> 29 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 15 Ala Gln Leu Lys Lys Lys Leu Gln Ala Asn Lys Lys Glu Leu Ala Gln 1 5 10 15 Leu Lys Trp Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala 20 25 <210> 16 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 16 Cys Leu Ser Phe Gly Thr Glu Ile Leu Thr Val Glu Tyr Gly Pro Leu 1 5 10 15 Pro Ile Gly Lys Ile Val Ser Glu Glu Ile Asn Cys Ser Val Tyr Ser 20 25 30 Val Asp Pro Glu Gly Arg Val Tyr Thr Gln Ala Ile Ala Gln Trp His 35 40 45 Asp Arg Gly Glu Gln Glu Val Leu Glu Tyr Glu Leu Glu Asp Gly Ser 50 55 60 Val Ile Arg Ala Thr Ser Asp His Arg Phe Leu Thr Thr Asp Tyr Gln 65 70 75 80 Leu Leu Ala Ile Glu Glu Ile Phe Ala Arg Gln Leu Asp Leu Leu Thr 85 90 95 Leu Glu Asn Ile Lys Gln Thr Glu Glu Ala Leu Asp Asn His Arg Leu 100 105 110 Pro Phe Pro Leu Leu Asp Ala Gly Thr Ile Lys 115 120 <210> 17 <211> 35 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 17 Val Lys Val Ile Gly Arg Arg Ser Leu Gly Val Gln Arg Ile Phe Asp 1 5 10 15 Ile Gly Leu Pro Gln Asp His Asn Phe Leu Leu Ala Asn Gly Ala Ile 20 25 30 Ala Ala Asn 35 <210> 18 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 18 Cys Ile Ser Gly Asp Ser Leu Ile Ser Leu Ala 1 5 10 <210> 19 <211> 143 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 19 Ser Thr Gly Lys Arg Val Ser Ile Lys Asp Leu Leu Asp Glu Lys Asp 1 5 10 15 Phe Glu Ile Trp Ala Ile Asn Glu Gln Thr Met Lys Leu Glu Ser Ala 20 25 30 Lys Val Ser Arg Val Phe Cys Thr Gly Lys Lys Leu Val Tyr Ile Leu 35 40 45 Lys Thr Arg Leu Gly Arg Thr Ile Lys Ala Thr Ala Asn His Arg Phe 50 55 60 Leu Thr Ile Asp Gly Trp Lys Arg Leu Asp Glu Leu Ser Leu Lys Glu 65 70 75 80 His Ile Ala Leu Pro Arg Lys Leu Glu Ser Ser Ser Leu Gln Leu Ser 85 90 95 Pro Glu Ile Glu Lys Leu Ser Gln Ser Asp Ile Tyr Trp Asp Ser Ile 100 105 110 Val Ser Ile Thr Glu Thr Gly Val Glu Glu Val Phe Asp Leu Thr Val 115 120 125 Pro Gly Pro His Asn Phe Val Ala Asn Asp Ile Ile Val His Asn 130 135 140 <210> 20 <211> 9219 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 20 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaaaaagcc tgaactcacc 660 gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 720 ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc 780 ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt 840 gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaatttag cgagagcctg 900 acctattgcc tttcatacga gaccgagatc ctgactgtcg agtacggatt gcttcctatc 960 ggcaaaatcg tggagaagag gattgaatgt accgtctatt cagtcgataa taatgggaac 1020 atctacacac agcccgtggc tcaatggcac gacagaggag agcaggaagt ttttgaatac 1080 tgtctcgagg acggatccct catccgcgct actaaagatc ataagtttat gaccgtggac 1140 ggccagatgc tgccaattga cgaaattttt gaacgagagc tggatctgat gagagtcgac 1200 aaccttccaa actgattaat taagaattcg acccagcttt cttgtacaaa gtggttggta 1260 agcctatccc taaccctctc ctcggtctcg attctacgta gtaatgagct agcagtctcg 1320 aggttaacga attccgcccc ccccctaacg ttactggccg aagccgcttg gaataaggcc 1380 ggtgtgcgct tgtctatatg ttattttcca ccatattgcc gtcttttggc aatgtgaggg 1440 cccggaaacc tggccctgtc ttcttgacga gcattcctag gggtctttcc cctctcgcca 1500 aaggaatgca aggtctgttg aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa 1560 gacaaacaac gtctgtagcg accctttgca ggcagcggaa ccccccacct ggcgacaggt 1620 gcccctgcgg ccaaaagcca cgtgtataag atacacctgc aaaggcggca caaccccagt 1680 gccacgttgt gagttggata gttgtggaaa gagtcaaatg gctctcctca agcgtattca 1740 acaaggggct gaaggatgcc cagaaggtac cccattgtat gggatctgat ctggggcctc 1800 ggtgcacatg ctttacatgt gtttagtcga ggttaaaaaa acgtctaggc cccccgaacc 1860 acggggacgt ggttttcctt tgaaaaacac gataatacca tggccatgag cgagctgatt 1920 aaggagaaca tgcacatgaa gctgtacatg gagggcaccg tggacaacca tcacttcaag 1980 tgcacatccg agggcgaagg caagccctac gagggcaccc agaccatgag aatcaaggtg 2040 gtcgagggcg gccctctccc cttcgccttc gacatcctgg ctactagctt cctctacggc 2100 agcaagacct tcatcaacca cacccagggc atccccgact tcttcaagca gtccttccct 2160 gagggcttca catgggagag agtcaccaca tacgaagacg ggggcgtgct gaccgctacc 2220 caggacacca gcctccagga cggctgcctc atctacaacg tcaagatcag aggggtgaac 2280 ttcacatcca acggccctgt gatgcagaag aaaacactcg gctgggaggc cttcaccgag 2340 acgctgtacc ccgctgacgg cggcctggaa ggcagaaacg acatggccct gaagctcgtg 2400 ggcgggagcc atctgatcgc aaacatcaag accacatata gatccaagaa acccgctaag 2460 aacctcaaga tgcctggcgt ctactatgtg gactacagac tggaaagaat caaggaggcc 2520 aacaacgaga cctacgtcga gcagcacgag gtggcagtgg ccagatactg cgacctccct 2580 agcaaactgg ggcacaagct taattaacac cggtggcgcg ttaagtcgac aatcaacctc 2640 tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct ccttttacgc 2700 tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt atggctttca 2760 ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg tggcccgttg 2820 tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact ggttggggca 2880 ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct attgccacgg 2940 cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg ttgggcactg 3000 acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc gcctgtgttg 3060 ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc aatccagcgg 3120 accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc 3180 ctcagacgag tcggatctcc ctttgggccg cctccccgcg tcgactttaa gaccaatgac 3240 ttacaaggca gctgtagatc ttagccactt tttaaaagaa aaggggggac tggaagggct 3300 aattcactcc caacgaagac aagatctgct ttttgcttgt actgggtctc tctggttaga 3360 ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata 3420 aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta 3480 gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagtacgt atagtagttc 3540 atgtcatctt attattcagt atttataact tgcaaagaaa tgaatatcag agagtgagag 3600 gaacttgttt attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac 3660 aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc 3720 ttatcatgtc tggctctagc tatcccgccc ctaactccgc ccatcccgcc cctaactccg 3780 cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc 3840 gaggccgcct cggcctctga gctattccag aagtagtgag gaggcttttt tggaggccta 3900 gggacgtacc caattcgccc tatagtgagt cgtattacgc gcgctcactg gccgtcgttt 3960 tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc 4020 cccctttcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt 4080 tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 4140 tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 4200 ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 4260 ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 4320 agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 4380 tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 4440 tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 4500 atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 4560 aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca 4620 ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa 4680 aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt 4740 ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca 4800 gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag 4860 ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc 4920 ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca 4980 gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt 5040 aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct 5100 gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt 5160 aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga 5220 caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact 5280 tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc 5340 acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga 5400 gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt 5460 agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga 5520 gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact 5580 ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga 5640 taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt 5700 agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca 5760 aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct 5820 ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc ttctagtgta 5880 gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct 5940 aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc 6000 aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca 6060 gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga 6120 aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg 6180 aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt 6240 cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag 6300 cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt 6360 tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt 6420 tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga 6480 ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta 6540 atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa 6600 tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcgtat 6660 gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta 6720 cgccaagcgc gcaattaacc ctcactaaag ggaacaaaag ctggagctgc aagcttaatg 6780 tagtcttatg caatactctt gtagtcttgc aacatggtaa cgatgagtta gcaacatgcc 6840 ttacaaggag agaaaaagca ccgtgcatgc cgattggtgg aagtaaggtg gtacgatcgt 6900 gccttattag gaaggcaaca gacgggtctg acatggattg gacgaaccac tgaattgccg 6960 cattgcagag atattgtatt taagtgccta gctcgataca taaacgggtc tctctggtta 7020 gaccagatct gagcctggga gctctctggc taactaggga acccactgct taagcctcaa 7080 taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac 7140 tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg cgcccgaaca 7200 gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact cggcttgctg 7260 aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa attttgacta 7320 gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg gggagaatta 7380 gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat aaattaaaac 7440 atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc ctgttagaaa 7500 catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag acaggatcag 7560 aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat caaaggatag 7620 agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac aaaagtaaga 7680 ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat gagggacaat 7740 tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc 7800 accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg 7860 ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg 7920 gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct 7980 attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca 8040 agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc 8100 tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct 8160 ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac 8220 acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa gaatgaacaa 8280 gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat aacaaattgg 8340 ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt aagaatagtt 8400 tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt atcgtttcag 8460 acccacctcc caaccccgag gggacccttg cgccttttcc aaggcagccc tgggtttgcg 8520 cagggacgcg gctgctctgg gcgtggttcc gggaaacgca gcggcgccga ccctgggtct 8580 cgcacattct tcacgtccgt tcgcagcgtc acccggatct tcgccgctac ccttgtgggc 8640 cccccggcga cgcttcctgc tccgccccta agtcgggaag gttccttgcg gttcgcggcg 8700 tgccggacgt gacaaacgga agccgcacgt ctcactagta ccctcgcaga cggacagcgc 8760 cagggagcaa tggcagcgcg ccgaccgcga tgggctgtgg ccaatagcgg ctgctcagca 8820 gggcgcgccg agagcagcgg ccgggaaggg gcggtgcggg aggcggggtg tggggcggta 8880 gtgtgggccc tgttcctgcc cgcgcggtgt tccgcattct gcaagcctcc ggagcgcacg 8940 tcggcagtcg gctccctcgt tgaccgaatc accgacctct ctccccaggg ggtacccagc 9000 tgtctagaga attctagatc ttgagacaaa tggcagtatt catccacaat tttaaaagaa 9060 aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca 9120 tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca 9180 gggacagcag agatccactt tggcgccggc tcgaggggg 9219 <210> 21 <211> 191 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 21 Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe Leu Ile 1 5 10 15 Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 20 25 30 Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 35 40 45 Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 50 55 60 Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 65 70 75 80 Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Leu Ser Tyr Glu Thr Glu 85 90 95 Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu 100 105 110 Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile 115 120 125 Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val 130 135 140 Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp 145 150 155 160 His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile 165 170 175 Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn 180 185 190 <210> 22 <211> 9516 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 22 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcatctccc gccgtgcaca gggtgtcacg 780 ttgcaagacc tgcctgaaac cgaactgccc gctgttctgc agccggtcgc ggaggccatg 840 gatgcgatcg ctgcggccga tcttagccag acgagcgggt tcggcccatt cggaccgcaa 900 ggaatcggtc aatacactac atggcgtgat ttcatatgcg cgattgctga tccccatgtg 960 tatcactggc aaactgtgat ggacgacacc gtcagtgcgt ccgtcgcgca ggctctcgat 1020 gagctgatgc tttgggccga ggactgcccc gaagtccggc acctcgtgca cgcggatttc 1080 ggctccaaca atgtcctgac ggacaatggc cgcataacag cggtcattga ctggagcgag 1140 gcgatgttcg gggattccca atacgaggtc gccaacatct tcttctggag gccgtggttg 1200 gcttgtatgg agcagcagac gcgctacttc gagcggaggc atccggagct tgcaggatcg 1260 ccgcggctcc gggcgtatat gctccgcatt ggtcttgacc aactctatca gagcttggtt 1320 gacggcaatt tcgatgatgc agcttgggcg cagggtcgat gcgacgcaat cgtccgatcc 1380 ggagccggga ctgtcgggcg tacacaaatc gcccgcagaa gcgcggccgt ctggaccgat 1440 ggctgtgtag aagtactcgc cgatagtgga aaccgacgcc ccagcactcg tccgagggca 1500 aaggaatagt taattaagaa ttcgacccag ctttcttgta caaagtggtt ggtaagccta 1560 tccctaaccc tctcctcggt ctcgattcta cgtagtaatg agctagcagt ctcgaggtta 1620 acgaattccg ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg 1680 cgcttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga 1740 aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa 1800 tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa 1860 caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcccct 1920 gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg 1980 ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg 2040 ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtgca 2100 catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg 2160 acgtggtttt cctttgaaaa acacgataat accatggtga gcaagggcga ggaggataac 2220 atggccatca tcaaggagtt catgcgcttc aaggtgcaca tggagggctc cgtgaacggc 2280 cacgagttcg agatcgaggg cgagggcgag ggccgcccct acgagggcac ccagaccgcc 2340 aagctgaagg tgaccaaggg tggccccctg cccttcgcct gggacatcct gtcccctcag 2400 ttcatgtacg gctccaaggc ctacgtgaag caccccgccg acatccccga ctacttgaag 2460 ctgtccttcc ccgagggctt caagtgggag cgcgtgatga acttcgagga cggcggcgtg 2520 gtgaccgtga cccaggactc ctccctgcag gacggcgagt tcatctacaa ggtgaagctg 2580 cgcggcacca acttcccctc cgacggcccc gtaatgcaga agaagaccat gggctgggag 2640 gcctcctccg agcggatgta ccccgaggac ggcgccctga agggcgagat caagcagagg 2700 ctgaagctga aggacggcgg ccactacgac gctgaggtca agaccaccta caaggccaag 2760 aagcccgtgc agctgcccgg cgcctacaac gtcaacatca agttggacat cacctcccac 2820 aacgaggact acaccatcgt ggaacagtac gaacgcgccg agggccgcca ctccaccggc 2880 ggcatggacg agctgtacaa gtaacaccgg tggcgcgtta agtcgacaat caacctctgg 2940 attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct tttacgctat 3000 gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg gctttcattt 3060 tctcctcctt gtataaatcc tggttgctgt ctctttatga ggagttgtgg cccgttgtca 3120 ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt tggggcattg 3180 ccaccacctg tcagctcctt tccgggactt tcgctttccc cctccctatt gccacggcgg 3240 aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg ggcactgaca 3300 attccgtggt gttgtcgggg aaatcatcgt cctttccttg gctgctcgcc tgtgttgcca 3360 cctggattct gcgcgggacg tccttctgct acgtcccttc ggccctcaat ccagcggacc 3420 ttccttcccg cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc cttcgccctc 3480 agacgagtcg gatctccctt tgggccgcct ccccgcgtcg actttaagac caatgactta 3540 caaggcagct gtagatctta gccacttttt aaaagaaaag gggggactgg aagggctaat 3600 tcactcccaa cgaagacaag atctgctttt tgcttgtact gggtctctct ggttagacca 3660 gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag 3720 cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag 3780 atccctcaga cccttttagt cagtgtggaa aatctctagc agtacgtata gtagttcatg 3840 tcatcttatt attcagtatt tataacttgc aaagaaatga atatcagaga gtgagaggaa 3900 cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa 3960 taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta 4020 tcatgtctgg ctctagctat cccgccccta actccgccca tcccgcccct aactccgccc 4080 agttccgccc attctccgcc ccatggctga ctaatttttt ttatttatgc agaggccgag 4140 gccgcctcgg cctctgagct attccagaag tagtgaggag gcttttttgg aggcctaggg 4200 acgtacccaa ttcgccctat agtgagtcgt attacgcgcg ctcactggcc gtcgttttac 4260 aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca gcacatcccc 4320 ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc 4380 gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg 4440 tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt 4500 tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc 4560 tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg 4620 gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg 4680 agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct 4740 cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg 4800 agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttagg 4860 tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc 4920 aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag 4980 gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg 5040 ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt 5100 gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt 5160 tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt 5220 attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa 5280 tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag 5340 agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac 5400 aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac 5460 tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac 5520 cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac 5580 tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact 5640 tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg 5700 tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt 5760 tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat 5820 aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta 5880 gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa 5940 tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga 6000 aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac 6060 aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt 6120 tccgaaggta actggcttca gcagagcgca gataccaaat actgttcttc tagtgtagcc 6180 gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat 6240 cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag 6300 acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc 6360 cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag 6420 cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac 6480 aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg 6540 gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct 6600 atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc 6660 tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga 6720 gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga 6780 agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg 6840 cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt 6900 gagttagctc actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt 6960 gtgtggaatt gtgagcggat aacaatttca cacaggaaac agctatgacc atgattacgc 7020 caagcgcgca attaaccctc actaaaggga acaaaagctg gagctgcaag cttaatgtag 7080 tcttatgcaa tactcttgta gtcttgcaac atggtaacga tgagttagca acatgcctta 7140 caaggagaga aaaagcaccg tgcatgccga ttggtggaag taaggtggta cgatcgtgcc 7200 ttattaggaa ggcaacagac gggtctgaca tggattggac gaaccactga attgccgcat 7260 tgcagagata ttgtatttaa gtgcctagct cgatacataa acgggtctct ctggttagac 7320 cagatctgag cctgggagct ctctggctaa ctagggaacc cactgcttaa gcctcaataa 7380 agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag 7440 agatccctca gaccctttta gtcagtgtgg aaaatctcta gcagtggcgc ccgaacaggg 7500 acttgaaagc gaaagggaaa ccagaggagc tctctcgacg caggactcgg cttgctgaag 7560 cgcgcacggc aagaggcgag gggcggcgac tggtgagtac gccaaaaatt ttgactagcg 7620 gaggctagaa ggagagagat gggtgcgaga gcgtcagtat taagcggggg agaattagat 7680 cgcgatggga aaaaattcgg ttaaggccag ggggaaagaa aaaatataaa ttaaaacata 7740 tagtatgggc aagcagggag ctagaacgat tcgcagttaa tcctggcctg ttagaaacat 7800 cagaaggctg tagacaaata ctgggacagc tacaaccatc ccttcagaca ggatcagaag 7860 aacttagatc attatataat acagtagcaa ccctctattg tgtgcatcaa aggatagaga 7920 taaaagacac caaggaagct ttagacaaga tagaggaaga gcaaaacaaa agtaagacca 7980 ccgcacagca agcggccgct gatcttcaga cctggaggag gagatatgag ggacaattgg 8040 agaagtgaat tatataaata taaagtagta aaaattgaac cattaggagt agcacccacc 8100 aaggcaaaga gaagagtggt gcagagagaa aaaagagcag tgggaatagg agctttgttc 8160 cttgggttct tgggagcagc aggaagcact atgggcgcag cgtcaatgac gctgacggta 8220 caggccagac aattattgtc tggtatagtg cagcagcaga acaatttgct gagggctatt 8280 gaggcgcaac agcatctgtt gcaactcaca gtctggggca tcaagcagct ccaggcaaga 8340 atcctggctg tggaaagata cctaaaggat caacagctcc tggggatttg gggttgctct 8400 ggaaaactca tttgcaccac tgctgtgcct tggaatgcta gttggagtaa taaatctctg 8460 gaacagattt ggaatcacac gacctggatg gagtgggaca gagaaattaa caattacaca 8520 agcttaatac actccttaat tgaagaatcg caaaaccagc aagaaaagaa tgaacaagaa 8580 ttattggaat tagataaatg ggcaagtttg tggaattggt ttaacataac aaattggctg 8640 tggtatataa aattattcat aatgatagta ggaggcttgg taggtttaag aatagttttt 8700 gctgtacttt ctatagtgaa tagagttagg cagggatatt caccattatc gtttcagacc 8760 cacctcccaa ccccgagggg acccttgcgc cttttccaag gcagccctgg gtttgcgcag 8820 ggacgcggct gctctgggcg tggttccggg aaacgcagcg gcgccgaccc tgggtctcgc 8880 acattcttca cgtccgttcg cagcgtcacc cggatcttcg ccgctaccct tgtgggcccc 8940 ccggcgacgc ttcctgctcc gcccctaagt cgggaaggtt ccttgcggtt cgcggcgtgc 9000 cggacgtgac aaacggaagc cgcacgtctc actagtaccc tcgcagacgg acagcgccag 9060 ggagcaatgg cagcgcgccg accgcgatgg gctgtggcca atagcggctg ctcagcaggg 9120 cgcgccgaga gcagcggccg ggaaggggcg gtgcgggagg cggggtgtgg ggcggtagtg 9180 tgggccctgt tcctgcccgc gcggtgttcc gcattctgca agcctccgga gcgcacgtcg 9240 gcagtcggct ccctcgttga ccgaatcacc gacctctctc cccagggggt acccagctgt 9300 ctagagaatt ctagatcttg agacaaatgg cagtattcat ccacaatttt aaaagaaaag 9360 gggggattgg ggggtacagt gcaggggaaa gaatagtaga cataatagca acagacatac 9420 aaactaaaga attacaaaaa caaattacaa aaattcaaaa ttttcgggtt tattacaggg 9480 acagcagaga tccactttgg cgccggctcg aggggg 9516 <210> 23 <211> 288 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 23 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Ile Ser Arg Arg Ala Gln Gly Val Thr Leu Gln 35 40 45 Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu Gln Pro Val Ala Glu 50 55 60 Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser Gln Thr Ser Gly Phe 65 70 75 80 Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr Thr Thr Trp Arg Asp 85 90 95 Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr His Trp Gln Thr Val 100 105 110 Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln Ala Leu Asp Glu Leu 115 120 125 Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg His Leu Val His Ala 130 135 140 Asp Phe Gly Ser Asn Asn Val Leu Thr Asp Asn Gly Arg Ile Thr Ala 145 150 155 160 Val Ile Asp Trp Ser Glu Ala Met Phe Gly Asp Ser Gln Tyr Glu Val 165 170 175 Ala Asn Ile Phe Phe Trp Arg Pro Trp Leu Ala Cys Met Glu Gln Gln 180 185 190 Thr Arg Tyr Phe Glu Arg Arg His Pro Glu Leu Ala Gly Ser Pro Arg 195 200 205 Leu Arg Ala Tyr Met Leu Arg Ile Gly Leu Asp Gln Leu Tyr Gln Ser 210 215 220 Leu Val Asp Gly Asn Phe Asp Asp Ala Ala Trp Ala Gln Gly Arg Cys 225 230 235 240 Asp Ala Ile Val Arg Ser Gly Ala Gly Thr Val Gly Arg Thr Gln Ile 245 250 255 Ala Arg Arg Ser Ala Ala Val Trp Thr Asp Gly Cys Val Glu Val Leu 260 265 270 Ala Asp Ser Gly Asn Arg Arg Pro Ser Thr Arg Pro Arg Ala Lys Glu 275 280 285 <210> 24 <211> 9279 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 24 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaaaaagcc tgaactcacc 660 gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 720 ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc 780 ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt 840 gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaatttag cgagagcctg 900 acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa 960 ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt 1020 agccagacga gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg 1080 cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac tgtgatggac 1140 gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc tgatgctttg ggccgaggac 1200 tgccccgaag tccggcacct cgtgcacgcg gatttcggct gtatcagtgg cgactccctg 1260 atctcactcg catgattaat taagaattcg acccagcttt cttgtacaaa gtggttggta 1320 agcctatccc taaccctctc ctcggtctcg attctacgta gtaatgagct agcagtctcg 1380 aggttaacga attccgcccc ccccctaacg ttactggccg aagccgcttg gaataaggcc 1440 ggtgtgcgct tgtctatatg ttattttcca ccatattgcc gtcttttggc aatgtgaggg 1500 cccggaaacc tggccctgtc ttcttgacga gcattcctag gggtctttcc cctctcgcca 1560 aaggaatgca aggtctgttg aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa 1620 gacaaacaac gtctgtagcg accctttgca ggcagcggaa ccccccacct ggcgacaggt 1680 gcccctgcgg ccaaaagcca cgtgtataag atacacctgc aaaggcggca caaccccagt 1740 gccacgttgt gagttggata gttgtggaaa gagtcaaatg gctctcctca agcgtattca 1800 acaaggggct gaaggatgcc cagaaggtac cccattgtat gggatctgat ctggggcctc 1860 ggtgcacatg ctttacatgt gtttagtcga ggttaaaaaa acgtctaggc cccccgaacc 1920 acggggacgt ggttttcctt tgaaaaacac gataatacca tggccatgag cgagctgatt 1980 aaggagaaca tgcacatgaa gctgtacatg gagggcaccg tggacaacca tcacttcaag 2040 tgcacatccg agggcgaagg caagccctac gagggcaccc agaccatgag aatcaaggtg 2100 gtcgagggcg gccctctccc cttcgccttc gacatcctgg ctactagctt cctctacggc 2160 agcaagacct tcatcaacca cacccagggc atccccgact tcttcaagca gtccttccct 2220 gagggcttca catgggagag agtcaccaca tacgaagacg ggggcgtgct gaccgctacc 2280 caggacacca gcctccagga cggctgcctc atctacaacg tcaagatcag aggggtgaac 2340 ttcacatcca acggccctgt gatgcagaag aaaacactcg gctgggaggc cttcaccgag 2400 acgctgtacc ccgctgacgg cggcctggaa ggcagaaacg acatggccct gaagctcgtg 2460 ggcgggagcc atctgatcgc aaacatcaag accacatata gatccaagaa acccgctaag 2520 aacctcaaga tgcctggcgt ctactatgtg gactacagac tggaaagaat caaggaggcc 2580 aacaacgaga cctacgtcga gcagcacgag gtggcagtgg ccagatactg cgacctccct 2640 agcaaactgg ggcacaagct taattaacac cggtggcgcg ttaagtcgac aatcaacctc 2700 tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct ccttttacgc 2760 tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt atggctttca 2820 ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg tggcccgttg 2880 tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact ggttggggca 2940 ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct attgccacgg 3000 cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg ttgggcactg 3060 acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc gcctgtgttg 3120 ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc aatccagcgg 3180 accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc 3240 ctcagacgag tcggatctcc ctttgggccg cctccccgcg tcgactttaa gaccaatgac 3300 ttacaaggca gctgtagatc ttagccactt tttaaaagaa aaggggggac tggaagggct 3360 aattcactcc caacgaagac aagatctgct ttttgcttgt actgggtctc tctggttaga 3420 ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata 3480 aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta 3540 gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagtacgt atagtagttc 3600 atgtcatctt attattcagt atttataact tgcaaagaaa tgaatatcag agagtgagag 3660 gaacttgttt attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac 3720 aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc 3780 ttatcatgtc tggctctagc tatcccgccc ctaactccgc ccatcccgcc cctaactccg 3840 cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc 3900 gaggccgcct cggcctctga gctattccag aagtagtgag gaggcttttt tggaggccta 3960 gggacgtacc caattcgccc tatagtgagt cgtattacgc gcgctcactg gccgtcgttt 4020 tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc 4080 cccctttcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt 4140 tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 4200 tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 4260 ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 4320 ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 4380 agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 4440 tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 4500 tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 4560 atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 4620 aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca 4680 ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa 4740 aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt 4800 ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca 4860 gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag 4920 ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc 4980 ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca 5040 gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt 5100 aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct 5160 gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt 5220 aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga 5280 caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact 5340 tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc 5400 acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga 5460 gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt 5520 agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga 5580 gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact 5640 ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga 5700 taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt 5760 agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca 5820 aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct 5880 ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc ttctagtgta 5940 gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct 6000 aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc 6060 aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca 6120 gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga 6180 aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg 6240 aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt 6300 cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag 6360 cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt 6420 tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt 6480 tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga 6540 ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta 6600 atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa 6660 tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcgtat 6720 gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta 6780 cgccaagcgc gcaattaacc ctcactaaag ggaacaaaag ctggagctgc aagcttaatg 6840 tagtcttatg caatactctt gtagtcttgc aacatggtaa cgatgagtta gcaacatgcc 6900 ttacaaggag agaaaaagca ccgtgcatgc cgattggtgg aagtaaggtg gtacgatcgt 6960 gccttattag gaaggcaaca gacgggtctg acatggattg gacgaaccac tgaattgccg 7020 cattgcagag atattgtatt taagtgccta gctcgataca taaacgggtc tctctggtta 7080 gaccagatct gagcctggga gctctctggc taactaggga acccactgct taagcctcaa 7140 taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac 7200 tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg cgcccgaaca 7260 gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact cggcttgctg 7320 aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa attttgacta 7380 gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg gggagaatta 7440 gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat aaattaaaac 7500 atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc ctgttagaaa 7560 catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag acaggatcag 7620 aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat caaaggatag 7680 agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac aaaagtaaga 7740 ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat gagggacaat 7800 tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc 7860 accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg 7920 ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg 7980 gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct 8040 attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca 8100 agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc 8160 tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct 8220 ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac 8280 acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa gaatgaacaa 8340 gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat aacaaattgg 8400 ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt aagaatagtt 8460 tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt atcgtttcag 8520 acccacctcc caaccccgag gggacccttg cgccttttcc aaggcagccc tgggtttgcg 8580 cagggacgcg gctgctctgg gcgtggttcc gggaaacgca gcggcgccga ccctgggtct 8640 cgcacattct tcacgtccgt tcgcagcgtc acccggatct tcgccgctac ccttgtgggc 8700 cccccggcga cgcttcctgc tccgccccta agtcgggaag gttccttgcg gttcgcggcg 8760 tgccggacgt gacaaacgga agccgcacgt ctcactagta ccctcgcaga cggacagcgc 8820 cagggagcaa tggcagcgcg ccgaccgcga tgggctgtgg ccaatagcgg ctgctcagca 8880 gggcgcgccg agagcagcgg ccgggaaggg gcggtgcggg aggcggggtg tggggcggta 8940 gtgtgggccc tgttcctgcc cgcgcggtgt tccgcattct gcaagcctcc ggagcgcacg 9000 tcggcagtcg gctccctcgt tgaccgaatc accgacctct ctccccaggg ggtacccagc 9060 tgtctagaga attctagatc ttgagacaaa tggcagtatt catccacaat tttaaaagaa 9120 aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca 9180 tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca 9240 gggacagcag agatccactt tggcgccggc tcgaggggg 9279 <210> 25 <211> 211 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 25 Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe Leu Ile 1 5 10 15 Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 20 25 30 Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 35 40 45 Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 50 55 60 Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 65 70 75 80 Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala Gln 85 90 95 Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu 100 105 110 Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser 115 120 125 Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr 130 135 140 Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr 145 150 155 160 His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln 165 170 175 Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg 180 185 190 His Leu Val His Ala Asp Phe Gly Cys Ile Ser Gly Asp Ser Leu Ile 195 200 205 Ser Leu Ala 210 <210> 26 <211> 9507 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 26 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgagcac tggaaagcga 660 gttagcatca aggacttgct ggacgaaaag gatttcgaaa tttgggcaat caatgagcag 720 accatgaaac tggagtctgc aaaggtgtcc cgggtgtttt gcacgggtaa gaagcttgtt 780 tatatcctta aaactagact gggccggacg atcaaagcca ccgcgaacca cagattcttg 840 acaatcgacg ggtggaaacg gctggacgaa ctgagcttga aggagcacat cgcccttcct 900 cggaagctcg agtcatcttc cctgcagctg agtcccgaaa tcgaaaagct ctctcagagc 960 gatatatatt gggactccat cgtaagcata acagagacgg gggtcgagga ggtgttcgat 1020 ctgacagttc ctgggcctca taatttcgta gcgaacgaca tcattgtaca taactccaac 1080 aatgtcctga cggacaatgg ccgcataaca gcggtcattg actggagcga ggcgatgttc 1140 ggggattccc aatacgaggt cgccaacatc ttcttctgga ggccgtggtt ggcttgtatg 1200 gagcagcaga cgcgctactt cgagcggagg catccggagc ttgcaggatc gccgcggctc 1260 cgggcgtata tgctccgcat tggtcttgac caactctatc agagcttggt tgacggcaat 1320 ttcgatgatg cagcttgggc gcagggtcga tgcgacgcaa tcgtccgatc cggagccggg 1380 actgtcgggc gtacacaaat cgcccgcaga agcgcggccg tctggaccga tggctgtgta 1440 gaagtactcg ccgatagtgg aaaccgacgc cccagcactc gtccgagggc aaaggaatag 1500 ttaattaaga attcgaccca gctttcttgt acaaagtggt tggtaagcct atccctaacc 1560 ctctcctcgg tctcgattct acgtagtaat gagctagcag tctcgaggtt aacgaattcc 1620 gccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt gcgcttgtct 1680 atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc 1740 ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc 1800 tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg 1860 tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcccc tgcggccaaa 1920 agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt 1980 ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg 2040 atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta 2100 catgtgttta gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt 2160 tcctttgaaa aacacgataa taccatggtg agcaagggcg aggaggataa catggccatc 2220 atcaaggagt tcatgcgctt caaggtgcac atggagggct ccgtgaacgg ccacgagttc 2280 gagatcgagg gcgagggcga gggccgcccc tacgagggca cccagaccgc caagctgaag 2340 gtgaccaagg gtggccccct gcccttcgcc tgggacatcc tgtcccctca gttcatgtac 2400 ggctccaagg cctacgtgaa gcaccccgcc gacatccccg actacttgaa gctgtccttc 2460 cccgagggct tcaagtggga gcgcgtgatg aacttcgagg acggcggcgt ggtgaccgtg 2520 acccaggact cctccctgca ggacggcgag ttcatctaca aggtgaagct gcgcggcacc 2580 aacttcccct ccgacggccc cgtaatgcag aagaagacca tgggctggga ggcctcctcc 2640 gagcggatgt accccgagga cggcgccctg aagggcgaga tcaagcagag gctgaagctg 2700 aaggacggcg gccactacga cgctgaggtc aagaccacct acaaggccaa gaagcccgtg 2760 cagctgcccg gcgcctacaa cgtcaacatc aagttggaca tcacctccca caacgaggac 2820 tacaccatcg tggaacagta cgaacgcgcc gagggccgcc actccaccgg cggcatggac 2880 gagctgtaca agtaacaccg gtggcgcgtt aagtcgacaa tcaacctctg gattacaaaa 2940 tttgtgaaag attgactggt attcttaact atgttgctcc ttttacgcta tgtggatacg 3000 ctgctttaat gcctttgtat catgctattg cttcccgtat ggctttcatt ttctcctcct 3060 tgtataaatc ctggttgctg tctctttatg aggagttgtg gcccgttgtc aggcaacgtg 3120 gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg ttggggcatt gccaccacct 3180 gtcagctcct ttccgggact ttcgctttcc ccctccctat tgccacggcg gaactcatcg 3240 ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt gggcactgac aattccgtgg 3300 tgttgtcggg gaaatcatcg tcctttcctt ggctgctcgc ctgtgttgcc acctggattc 3360 tgcgcgggac gtccttctgc tacgtccctt cggccctcaa tccagcggac cttccttccc 3420 gcggcctgct gccggctctg cggcctcttc cgcgtcttcg ccttcgccct cagacgagtc 3480 ggatctccct ttgggccgcc tccccgcgtc gactttaaga ccaatgactt acaaggcagc 3540 tgtagatctt agccactttt taaaagaaaa ggggggactg gaagggctaa ttcactccca 3600 acgaagacaa gatctgcttt ttgcttgtac tgggtctctc tggttagacc agatctgagc 3660 ctgggagctc tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg 3720 agtgcttcaa gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag 3780 acccttttag tcagtgtgga aaatctctag cagtacgtat agtagttcat gtcatcttat 3840 tattcagtat ttataacttg caaagaaatg aatatcagag agtgagagga acttgtttat 3900 tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 3960 tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg 4020 gctctagcta tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc 4080 cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg 4140 gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg gacgtaccca 4200 attcgcccta tagtgagtcg tattacgcgc gctcactggc cgtcgtttta caacgtcgtg 4260 actgggaaaa ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca 4320 gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga 4380 atggcgaatg ggacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc 4440 gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt 4500 cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag 4560 ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt 4620 cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt 4680 tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt 4740 cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt 4800 aacaaaaatt taacgcgaat tttaacaaaa tattaacgct tacaatttag gtggcacttt 4860 tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta 4920 tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat 4980 gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt 5040 ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg 5100 agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga 5160 agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg 5220 tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt 5280 tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg 5340 cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg 5400 aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga 5460 tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc 5520 tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc 5580 ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc 5640 ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg 5700 cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac 5760 gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc 5820 actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt 5880 aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac 5940 caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa 6000 aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc 6060 accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt 6120 aactggcttc agcagagcgc agataccaaa tactgttctt ctagtgtagc cgtagttagg 6180 ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc 6240 agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt 6300 accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga 6360 gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct 6420 tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg 6480 cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca 6540 cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa 6600 cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt 6660 ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga 6720 taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga 6780 gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca 6840 cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg tgagttagct 6900 cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt tgtgtggaat 6960 tgtgagcgga taacaatttc acacaggaaa cagctatgac catgattacg ccaagcgcgc 7020 aattaaccct cactaaaggg aacaaaagct ggagctgcaa gcttaatgta gtcttatgca 7080 atactcttgt agtcttgcaa catggtaacg atgagttagc aacatgcctt acaaggagag 7140 aaaaagcacc gtgcatgccg attggtggaa gtaaggtggt acgatcgtgc cttattagga 7200 aggcaacaga cgggtctgac atggattgga cgaaccactg aattgccgca ttgcagagat 7260 attgtattta agtgcctagc tcgatacata aacgggtctc tctggttaga ccagatctga 7320 gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct 7380 tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc 7440 agaccctttt agtcagtgtg gaaaatctct agcagtggcg cccgaacagg gacttgaaag 7500 cgaaagggaa accagaggag ctctctcgac gcaggactcg gcttgctgaa gcgcgcacgg 7560 caagaggcga ggggcggcga ctggtgagta cgccaaaaat tttgactagc ggaggctaga 7620 aggagagaga tgggtgcgag agcgtcagta ttaagcgggg gagaattaga tcgcgatggg 7680 aaaaaattcg gttaaggcca gggggaaaga aaaaatataa attaaaacat atagtatggg 7740 caagcaggga gctagaacga ttcgcagtta atcctggcct gttagaaaca tcagaaggct 7800 gtagacaaat actgggacag ctacaaccat cccttcagac aggatcagaa gaacttagat 7860 cattatataa tacagtagca accctctatt gtgtgcatca aaggatagag ataaaagaca 7920 ccaaggaagc tttagacaag atagaggaag agcaaaacaa aagtaagacc accgcacagc 7980 aagcggccgc tgatcttcag acctggagga ggagatatga gggacaattg gagaagtgaa 8040 ttatataaat ataaagtagt aaaaattgaa ccattaggag tagcacccac caaggcaaag 8100 agaagagtgg tgcagagaga aaaaagagca gtgggaatag gagctttgtt ccttgggttc 8160 ttgggagcag caggaagcac tatgggcgca gcgtcaatga cgctgacggt acaggccaga 8220 caattattgt ctggtatagt gcagcagcag aacaatttgc tgagggctat tgaggcgcaa 8280 cagcatctgt tgcaactcac agtctggggc atcaagcagc tccaggcaag aatcctggct 8340 gtggaaagat acctaaagga tcaacagctc ctggggattt ggggttgctc tggaaaactc 8400 atttgcacca ctgctgtgcc ttggaatgct agttggagta ataaatctct ggaacagatt 8460 tggaatcaca cgacctggat ggagtgggac agagaaatta acaattacac aagcttaata 8520 cactccttaa ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga attattggaa 8580 ttagataaat gggcaagttt gtggaattgg tttaacataa caaattggct gtggtatata 8640 aaattattca taatgatagt aggaggcttg gtaggtttaa gaatagtttt tgctgtactt 8700 tctatagtga atagagttag gcagggatat tcaccattat cgtttcagac ccacctccca 8760 accccgaggg gacccttgcg ccttttccaa ggcagccctg ggtttgcgca gggacgcggc 8820 tgctctgggc gtggttccgg gaaacgcagc ggcgccgacc ctgggtctcg cacattcttc 8880 acgtccgttc gcagcgtcac ccggatcttc gccgctaccc ttgtgggccc cccggcgacg 8940 cttcctgctc cgcccctaag tcgggaaggt tccttgcggt tcgcggcgtg ccggacgtga 9000 caaacggaag ccgcacgtct cactagtacc ctcgcagacg gacagcgcca gggagcaatg 9060 gcagcgcgcc gaccgcgatg ggctgtggcc aatagcggct gctcagcagg gcgcgccgag 9120 agcagcggcc gggaaggggc ggtgcgggag gcggggtgtg gggcggtagt gtgggccctg 9180 ttcctgcccg cgcggtgttc cgcattctgc aagcctccgg agcgcacgtc ggcagtcggc 9240 tccctcgttg accgaatcac cgacctctct ccccaggggg tacccagctg tctagagaat 9300 tctagatctt gagacaaatg gcagtattca tccacaattt taaaagaaaa ggggggattg 9360 gggggtacag tgcaggggaa agaatagtag acataatagc aacagacata caaactaaag 9420 aattacaaaa acaaattaca aaaattcaaa attttcgggt ttattacagg gacagcagag 9480 atccactttg gcgccggctc gaggggg 9507 <210> 27 <211> 285 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 27 Met Ser Thr Gly Lys Arg Val Ser Ile Lys Asp Leu Leu Asp Glu Lys 1 5 10 15 Asp Phe Glu Ile Trp Ala Ile Asn Glu Gln Thr Met Lys Leu Glu Ser 20 25 30 Ala Lys Val Ser Arg Val Phe Cys Thr Gly Lys Lys Leu Val Tyr Ile 35 40 45 Leu Lys Thr Arg Leu Gly Arg Thr Ile Lys Ala Thr Ala Asn His Arg 50 55 60 Phe Leu Thr Ile Asp Gly Trp Lys Arg Leu Asp Glu Leu Ser Leu Lys 65 70 75 80 Glu His Ile Ala Leu Pro Arg Lys Leu Glu Ser Ser Ser Leu Gln Leu 85 90 95 Ser Pro Glu Ile Glu Lys Leu Ser Gln Ser Asp Ile Tyr Trp Asp Ser 100 105 110 Ile Val Ser Ile Thr Glu Thr Gly Val Glu Glu Val Phe Asp Leu Thr 115 120 125 Val Pro Gly Pro His Asn Phe Val Ala Asn Asp Ile Ile Val His Asn 130 135 140 Ser Asn Asn Val Leu Thr Asp Asn Gly Arg Ile Thr Ala Val Ile Asp 145 150 155 160 Trp Ser Glu Ala Met Phe Gly Asp Ser Gln Tyr Glu Val Ala Asn Ile 165 170 175 Phe Phe Trp Arg Pro Trp Leu Ala Cys Met Glu Gln Gln Thr Arg Tyr 180 185 190 Phe Glu Arg Arg His Pro Glu Leu Ala Gly Ser Pro Arg Leu Arg Ala 195 200 205 Tyr Met Leu Arg Ile Gly Leu Asp Gln Leu Tyr Gln Ser Leu Val Asp 210 215 220 Gly Asn Phe Asp Asp Ala Ala Trp Ala Gln Gly Arg Cys Asp Ala Ile 225 230 235 240 Val Arg Ser Gly Ala Gly Thr Val Gly Arg Thr Gln Ile Ala Arg Arg 245 250 255 Ser Ala Ala Val Trp Thr Asp Gly Cys Val Glu Val Leu Ala Asp Ser 260 265 270 Gly Asn Arg Arg Pro Ser Thr Arg Pro Arg Ala Lys Glu 275 280 285 <210> 28 <211> 9108 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 28 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaaaaagcc tgaactcacc 660 gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 720 ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc 780 ctgcgggtaa atagctgcct ttcatacgag accgagatcc tgactgtcga gtacggattg 840 cttcctatcg gcaaaatcgt ggagaagagg attgaatgta ccgtctattc agtcgataat 900 aatgggaaca tctacacaca gcccgtggct caatggcacg acagaggaga gcaggaagtt 960 tttgaatact gtctcgagga cggatccctc atccgcgcta ctaaagatca taagtttatg 1020 accgtggacg gccagatgct gccaattgac gaaatttttg aacgagagct ggatctgatg 1080 agagtcgaca accttccaaa ctgattaatt aagaattcga cccagctttc ttgtacaaag 1140 tggttggtaa gcctatccct aaccctctcc tcggtctcga ttctacgtag taatgagcta 1200 gcagtctcga ggttaacgaa ttccgccccc cccctaacgt tactggccga agccgcttgg 1260 aataaggccg gtgtgcgctt gtctatatgt tattttccac catattgccg tcttttggca 1320 atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg ggtctttccc 1380 ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt cctctggaag 1440 cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac cccccacctg 1500 gcgacaggtg cccctgcggc caaaagccac gtgtataaga tacacctgca aaggcggcac 1560 aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg ctctcctcaa 1620 gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg ggatctgatc 1680 tggggcctcg gtgcacatgc tttacatgtg tttagtcgag gttaaaaaaa cgtctaggcc 1740 ccccgaacca cggggacgtg gttttccttt gaaaaacacg ataataccat ggccatgagc 1800 gagctgatta aggagaacat gcacatgaag ctgtacatgg agggcaccgt ggacaaccat 1860 cacttcaagt gcacatccga gggcgaaggc aagccctacg agggcaccca gaccatgaga 1920 atcaaggtgg tcgagggcgg ccctctcccc ttcgccttcg acatcctggc tactagcttc 1980 ctctacggca gcaagacctt catcaaccac acccagggca tccccgactt cttcaagcag 2040 tccttccctg agggcttcac atgggagaga gtcaccacat acgaagacgg gggcgtgctg 2100 accgctaccc aggacaccag cctccaggac ggctgcctca tctacaacgt caagatcaga 2160 ggggtgaact tcacatccaa cggccctgtg atgcagaaga aaacactcgg ctgggaggcc 2220 ttcaccgaga cgctgtaccc cgctgacggc ggcctggaag gcagaaacga catggccctg 2280 aagctcgtgg gcgggagcca tctgatcgca aacatcaaga ccacatatag atccaagaaa 2340 cccgctaaga acctcaagat gcctggcgtc tactatgtgg actacagact ggaaagaatc 2400 aaggaggcca acaacgagac ctacgtcgag cagcacgagg tggcagtggc cagatactgc 2460 gacctcccta gcaaactggg gcacaagctt aattaacacc ggtggcgcgt taagtcgaca 2520 atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc 2580 cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta 2640 tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt 2700 ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg 2760 gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta 2820 ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt 2880 tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg 2940 cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca 3000 atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc 3060 gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgcgt cgactttaag 3120 accaatgact tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact 3180 ggaagggcta attcactccc aacgaagaca agatctgctt tttgcttgta ctgggtctct 3240 ctggttagac cagatctgag cctgggagct ctctggctaa ctagggaacc cactgcttaa 3300 gcctcaataa agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc 3360 tggtaactag agatccctca gaccctttta gtcagtgtgg aaaatctcta gcagtacgta 3420 tagtagttca tgtcatctta ttattcagta tttataactt gcaaagaaat gaatatcaga 3480 gagtgagagg aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac 3540 aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat 3600 caatgtatct tatcatgtct ggctctagct atcccgcccc taactccgcc catcccgccc 3660 ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat 3720 gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg aggctttttt 3780 ggaggcctag ggacgtaccc aattcgccct atagtgagtc gtattacgcg cgctcactgg 3840 ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 3900 cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 3960 cccaacagtt gcgcagcctg aatggcgaat gggacgcgcc ctgtagcggc gcattaagcg 4020 cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg 4080 ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc 4140 taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa 4200 aacttgatta gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc 4260 ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac 4320 tcaaccctat ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt 4380 ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa atattaacgc 4440 ttacaattta ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt 4500 ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata 4560 atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt 4620 tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc 4680 tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat 4740 ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct 4800 atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc gccgcataca 4860 ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg 4920 catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa 4980 cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg 5040 ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga 5100 cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg 5160 cgaactactt actctagctt cccggcaaca attaatagac tggatggagg cggataaagt 5220 tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg 5280 agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc 5340 ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca 5400 gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc 5460 atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat 5520 cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc 5580 agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg 5640 ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct 5700 accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa atactgttct 5760 tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct 5820 cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg 5880 gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc 5940 gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga 6000 gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg 6060 cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta 6120 tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg 6180 ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg 6240 ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat 6300 taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc 6360 agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg cgcgttggcc 6420 gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa 6480 cgcaattaat gtgagttagc tcactcatta ggcaccccag gctttacact ttatgcttcc 6540 ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa acagctatga 6600 ccatgattac gccaagcgcg caattaaccc tcactaaagg gaacaaaagc tggagctgca 6660 agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag 6720 caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg 6780 tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact 6840 gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacat aaacgggtct 6900 ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt 6960 aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac 7020 tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc 7080 gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc 7140 ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa 7200 ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg 7260 ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata 7320 aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc 7380 tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga 7440 caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc 7500 aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca 7560 aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg 7620 agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga 7680 gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata 7740 ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg 7800 acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg 7860 ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag 7920 ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt 7980 tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt 8040 aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt 8100 aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag 8160 aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata 8220 acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta 8280 agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta 8340 tcgtttcaga cccacctccc aaccccgagg ggacccttgc gccttttcca aggcagccct 8400 gggtttgcgc agggacgcgg ctgctctggg cgtggttccg ggaaacgcag cggcgccgac 8460 cctgggtctc gcacattctt cacgtccgtt cgcagcgtca cccggatctt cgccgctacc 8520 cttgtgggcc ccccggcgac gcttcctgct ccgcccctaa gtcgggaagg ttccttgcgg 8580 ttcgcggcgt gccggacgtg acaaacggaa gccgcacgtc tcactagtac cctcgcagac 8640 ggacagcgcc agggagcaat ggcagcgcgc cgaccgcgat gggctgtggc caatagcggc 8700 tgctcagcag ggcgcgccga gagcagcggc cgggaagggg cggtgcggga ggcggggtgt 8760 ggggcggtag tgtgggccct gttcctgccc gcgcggtgtt ccgcattctg caagcctccg 8820 gagcgcacgt cggcagtcgg ctccctcgtt gaccgaatca ccgacctctc tccccagggg 8880 gtacccagct gtctagagaa ttctagatct tgagacaaat ggcagtattc atccacaatt 8940 ttaaaagaaa aggggggatt ggggggtaca gtgcagggga aagaatagta gacataatag 9000 caacagacat acaaactaaa gaattacaaa aacaaattac aaaaattcaa aattttcggg 9060 tttattacag ggacagcaga gatccacttt ggcgccggct cgaggggg 9108 <210> 29 <211> 154 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 29 Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe Leu Ile 1 5 10 15 Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 20 25 30 Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 35 40 45 Arg Val Asn Ser Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu 50 55 60 Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys 65 70 75 80 Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val 85 90 95 Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu 100 105 110 Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr 115 120 125 Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu 130 135 140 Asp Leu Met Arg Val Asp Asn Leu Pro Asn 145 150 <210> 30 <211> 9627 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 30 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcgccgatg gtttctacaa agatcgttat 780 gtttatcggc actttgcatc ggccgcgctc ccgattccgg aagtgcttga cattggggaa 840 tttagcgaga gcctgaccta ttgcatctcc cgccgtgcac agggtgtcac gttgcaagac 900 ctgcctgaaa ccgaactgcc cgctgttctg cagccggtcg cggaggccat ggatgcgatc 960 gctgcggccg atcttagcca gacgagcggg ttcggcccat tcggaccaca aggaatcggt 1020 caatacacta catggcgtga tttcatatgc gcgattgctg atccccatgt gtatcactgg 1080 caaactgtga tggacgacac cgtcagtgcg tccgtcgcgc aggctctcga tgagctgatg 1140 ctttgggccg aggactgccc cgaagtccgg cacctcgtgc acgcggattt cggctccaac 1200 aatgtcctga cggacaatgg ccgcataaca gcggtcattg actggagcga ggcgatgttc 1260 ggggattccc aatacgaggt cgccaacatc ttcttctgga ggccgtggtt ggcttgtatg 1320 gagcagcaga cgcgctactt cgagcggagg catccggagc ttgcaggatc gccgcggctc 1380 cgggcgtata tgctccgcat tggtcttgac caactctatc agagcttggt tgacggcaat 1440 ttcgatgatg cagcttgggc gcagggtcga tgcgacgcaa tcgtccgatc cggagccggg 1500 actgtcgggc gtacacaaat cgcccgcaga agcgcggccg tctggaccga tggctgtgta 1560 gaagtactcg ccgatagtgg aaaccgacgc cccagcactc gtccgagggc aaaggaatag 1620 ttaattaaga attcgaccca gctttcttgt acaaagtggt tggtaagcct atccctaacc 1680 ctctcctcgg tctcgattct acgtagtaat gagctagcag tctcgaggtt aacgaattcc 1740 gccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt gcgcttgtct 1800 atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc 1860 ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc 1920 tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg 1980 tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcccc tgcggccaaa 2040 agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt 2100 ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg 2160 atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta 2220 catgtgttta gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt 2280 tcctttgaaa aacacgataa taccatggtg agcaagggcg aggaggataa catggccatc 2340 atcaaggagt tcatgcgctt caaggtgcac atggagggct ccgtgaacgg ccacgagttc 2400 gagatcgagg gcgagggcga gggccgcccc tacgagggca cccagaccgc caagctgaag 2460 gtgaccaagg gtggccccct gcccttcgcc tgggacatcc tgtcccctca gttcatgtac 2520 ggctccaagg cctacgtgaa gcaccccgcc gacatccccg actacttgaa gctgtccttc 2580 cccgagggct tcaagtggga gcgcgtgatg aacttcgagg acggcggcgt ggtgaccgtg 2640 acccaggact cctccctgca ggacggcgag ttcatctaca aggtgaagct gcgcggcacc 2700 aacttcccct ccgacggccc cgtaatgcag aagaagacca tgggctggga ggcctcctcc 2760 gagcggatgt accccgagga cggcgccctg aagggcgaga tcaagcagag gctgaagctg 2820 aaggacggcg gccactacga cgctgaggtc aagaccacct acaaggccaa gaagcccgtg 2880 cagctgcccg gcgcctacaa cgtcaacatc aagttggaca tcacctccca caacgaggac 2940 tacaccatcg tggaacagta cgaacgcgcc gagggccgcc actccaccgg cggcatggac 3000 gagctgtaca agtaacaccg gtggcgcgtt aagtcgacaa tcaacctctg gattacaaaa 3060 tttgtgaaag attgactggt attcttaact atgttgctcc ttttacgcta tgtggatacg 3120 ctgctttaat gcctttgtat catgctattg cttcccgtat ggctttcatt ttctcctcct 3180 tgtataaatc ctggttgctg tctctttatg aggagttgtg gcccgttgtc aggcaacgtg 3240 gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg ttggggcatt gccaccacct 3300 gtcagctcct ttccgggact ttcgctttcc ccctccctat tgccacggcg gaactcatcg 3360 ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt gggcactgac aattccgtgg 3420 tgttgtcggg gaaatcatcg tcctttcctt ggctgctcgc ctgtgttgcc acctggattc 3480 tgcgcgggac gtccttctgc tacgtccctt cggccctcaa tccagcggac cttccttccc 3540 gcggcctgct gccggctctg cggcctcttc cgcgtcttcg ccttcgccct cagacgagtc 3600 ggatctccct ttgggccgcc tccccgcgtc gactttaaga ccaatgactt acaaggcagc 3660 tgtagatctt agccactttt taaaagaaaa ggggggactg gaagggctaa ttcactccca 3720 acgaagacaa gatctgcttt ttgcttgtac tgggtctctc tggttagacc agatctgagc 3780 ctgggagctc tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg 3840 agtgcttcaa gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag 3900 acccttttag tcagtgtgga aaatctctag cagtacgtat agtagttcat gtcatcttat 3960 tattcagtat ttataacttg caaagaaatg aatatcagag agtgagagga acttgtttat 4020 tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 4080 tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg 4140 gctctagcta tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc 4200 cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg 4260 gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg gacgtaccca 4320 attcgcccta tagtgagtcg tattacgcgc gctcactggc cgtcgtttta caacgtcgtg 4380 actgggaaaa ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca 4440 gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga 4500 atggcgaatg ggacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc 4560 gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt 4620 cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag 4680 ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt 4740 cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt 4800 tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt 4860 cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt 4920 aacaaaaatt taacgcgaat tttaacaaaa tattaacgct tacaatttag gtggcacttt 4980 tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta 5040 tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat 5100 gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt 5160 ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg 5220 agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga 5280 agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg 5340 tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt 5400 tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg 5460 cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg 5520 aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga 5580 tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc 5640 tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc 5700 ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc 5760 ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg 5820 cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac 5880 gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc 5940 actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt 6000 aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac 6060 caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa 6120 aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc 6180 accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt 6240 aactggcttc agcagagcgc agataccaaa tactgttctt ctagtgtagc cgtagttagg 6300 ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc 6360 agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt 6420 accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga 6480 gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct 6540 tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg 6600 cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca 6660 cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa 6720 cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt 6780 ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga 6840 taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga 6900 gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca 6960 cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg tgagttagct 7020 cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt tgtgtggaat 7080 tgtgagcgga taacaatttc acacaggaaa cagctatgac catgattacg ccaagcgcgc 7140 aattaaccct cactaaaggg aacaaaagct ggagctgcaa gcttaatgta gtcttatgca 7200 atactcttgt agtcttgcaa catggtaacg atgagttagc aacatgcctt acaaggagag 7260 aaaaagcacc gtgcatgccg attggtggaa gtaaggtggt acgatcgtgc cttattagga 7320 aggcaacaga cgggtctgac atggattgga cgaaccactg aattgccgca ttgcagagat 7380 attgtattta agtgcctagc tcgatacata aacgggtctc tctggttaga ccagatctga 7440 gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct 7500 tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc 7560 agaccctttt agtcagtgtg gaaaatctct agcagtggcg cccgaacagg gacttgaaag 7620 cgaaagggaa accagaggag ctctctcgac gcaggactcg gcttgctgaa gcgcgcacgg 7680 caagaggcga ggggcggcga ctggtgagta cgccaaaaat tttgactagc ggaggctaga 7740 aggagagaga tgggtgcgag agcgtcagta ttaagcgggg gagaattaga tcgcgatggg 7800 aaaaaattcg gttaaggcca gggggaaaga aaaaatataa attaaaacat atagtatggg 7860 caagcaggga gctagaacga ttcgcagtta atcctggcct gttagaaaca tcagaaggct 7920 gtagacaaat actgggacag ctacaaccat cccttcagac aggatcagaa gaacttagat 7980 cattatataa tacagtagca accctctatt gtgtgcatca aaggatagag ataaaagaca 8040 ccaaggaagc tttagacaag atagaggaag agcaaaacaa aagtaagacc accgcacagc 8100 aagcggccgc tgatcttcag acctggagga ggagatatga gggacaattg gagaagtgaa 8160 ttatataaat ataaagtagt aaaaattgaa ccattaggag tagcacccac caaggcaaag 8220 agaagagtgg tgcagagaga aaaaagagca gtgggaatag gagctttgtt ccttgggttc 8280 ttgggagcag caggaagcac tatgggcgca gcgtcaatga cgctgacggt acaggccaga 8340 caattattgt ctggtatagt gcagcagcag aacaatttgc tgagggctat tgaggcgcaa 8400 cagcatctgt tgcaactcac agtctggggc atcaagcagc tccaggcaag aatcctggct 8460 gtggaaagat acctaaagga tcaacagctc ctggggattt ggggttgctc tggaaaactc 8520 atttgcacca ctgctgtgcc ttggaatgct agttggagta ataaatctct ggaacagatt 8580 tggaatcaca cgacctggat ggagtgggac agagaaatta acaattacac aagcttaata 8640 cactccttaa ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga attattggaa 8700 ttagataaat gggcaagttt gtggaattgg tttaacataa caaattggct gtggtatata 8760 aaattattca taatgatagt aggaggcttg gtaggtttaa gaatagtttt tgctgtactt 8820 tctatagtga atagagttag gcagggatat tcaccattat cgtttcagac ccacctccca 8880 accccgaggg gacccttgcg ccttttccaa ggcagccctg ggtttgcgca gggacgcggc 8940 tgctctgggc gtggttccgg gaaacgcagc ggcgccgacc ctgggtctcg cacattcttc 9000 acgtccgttc gcagcgtcac ccggatcttc gccgctaccc ttgtgggccc cccggcgacg 9060 cttcctgctc cgcccctaag tcgggaaggt tccttgcggt tcgcggcgtg ccggacgtga 9120 caaacggaag ccgcacgtct cactagtacc ctcgcagacg gacagcgcca gggagcaatg 9180 gcagcgcgcc gaccgcgatg ggctgtggcc aatagcggct gctcagcagg gcgcgccgag 9240 agcagcggcc gggaaggggc ggtgcgggag gcggggtgtg gggcggtagt gtgggccctg 9300 ttcctgcccg cgcggtgttc cgcattctgc aagcctccgg agcgcacgtc ggcagtcggc 9360 tccctcgttg accgaatcac cgacctctct ccccaggggg tacccagctg tctagagaat 9420 tctagatctt gagacaaatg gcagtattca tccacaattt taaaagaaaa ggggggattg 9480 gggggtacag tgcaggggaa agaatagtag acataatagc aacagacata caaactaaag 9540 aattacaaaa acaaattaca aaaattcaaa attttcgggt ttattacagg gacagcagag 9600 atccactttg gcgccggctc gaggggg 9627 <210> 31 <211> 325 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 31 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 35 40 45 Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 50 55 60 Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala Gln 65 70 75 80 Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu 85 90 95 Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser 100 105 110 Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr 115 120 125 Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr 130 135 140 His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln 145 150 155 160 Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg 165 170 175 His Leu Val His Ala Asp Phe Gly Ser Asn Asn Val Leu Thr Asp Asn 180 185 190 Gly Arg Ile Thr Ala Val Ile Asp Trp Ser Glu Ala Met Phe Gly Asp 195 200 205 Ser Gln Tyr Glu Val Ala Asn Ile Phe Phe Trp Arg Pro Trp Leu Ala 210 215 220 Cys Met Glu Gln Gln Thr Arg Tyr Phe Glu Arg Arg His Pro Glu Leu 225 230 235 240 Ala Gly Ser Pro Arg Leu Arg Ala Tyr Met Leu Arg Ile Gly Leu Asp 245 250 255 Gln Leu Tyr Gln Ser Leu Val Asp Gly Asn Phe Asp Asp Ala Ala Trp 260 265 270 Ala Gln Gly Arg Cys Asp Ala Ile Val Arg Ser Gly Ala Gly Thr Val 275 280 285 Gly Arg Thr Gln Ile Ala Arg Arg Ser Ala Ala Val Trp Thr Asp Gly 290 295 300 Cys Val Glu Val Leu Ala Asp Ser Gly Asn Arg Arg Pro Ser Thr Arg 305 310 315 320 Pro Arg Ala Lys Glu 325 <210> 32 <211> 9672 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 32 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaaaaagcc tgaactcacc 660 gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 720 ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc 780 ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt 840 gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaatttag cgagagcctg 900 acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa 960 ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt 1020 agccagacga gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg 1080 cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac tgtgatggac 1140 gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc tgatgctttg ggccgaggac 1200 tgccccgaag tccggcacct cgtgcacgcg gatttcggct ccaacaatgt cctgacggac 1260 aatggccgca taacagcggt cattgactgg agcgaggcga tgttcgggga ttcccaatac 1320 gaggtcgcca acatcttctt ctggaggccg tggttggctt gcctttcata cgagaccgag 1380 atcctgactg tcgagtacgg attgcttcct atcggcaaaa tcgtggagaa gaggattgaa 1440 tgtaccgtct attcagtcga taataatggg aacatctaca cacagcccgt ggctcaatgg 1500 cacgacagag gagagcagga agtttttgaa tactgtctcg aggacggatc cctcatccgc 1560 gctactaaag atcataagtt tatgaccgtg gacggccaga tgctgccaat tgacgaaatt 1620 tttgaacgag agctggatct gatgagagtc gacaaccttc caaactgatt aattaagaat 1680 tcgacccagc tttcttgtac aaagtggttg gtaagcctat ccctaaccct ctcctcggtc 1740 tcgattctac gtagtaatga gctagcagtc tcgaggttaa cgaattccgc ccccccccta 1800 acgttactgg ccgaagccgc ttggaataag gccggtgtgc gcttgtctat atgttatttt 1860 ccaccatatt gccgtctttt ggcaatgtga gggcccggaa acctggccct gtcttcttga 1920 cgagcattcc taggggtctt tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg 1980 tgaaggaagc agttcctctg gaagcttctt gaagacaaac aacgtctgta gcgacccttt 2040 gcaggcagcg gaacccccca cctggcgaca ggtgcccctg cggccaaaag ccacgtgtat 2100 aagatacacc tgcaaaggcg gcacaacccc agtgccacgt tgtgagttgg atagttgtgg 2160 aaagagtcaa atggctctcc tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg 2220 taccccattg tatgggatct gatctggggc ctcggtgcac atgctttaca tgtgtttagt 2280 cgaggttaaa aaaacgtcta ggccccccga accacgggga cgtggttttc ctttgaaaaa 2340 cacgataata ccatggccat gagcgagctg attaaggaga acatgcacat gaagctgtac 2400 atggagggca ccgtggacaa ccatcacttc aagtgcacat ccgagggcga aggcaagccc 2460 tacgagggca cccagaccat gagaatcaag gtggtcgagg gcggccctct ccccttcgcc 2520 ttcgacatcc tggctactag cttcctctac ggcagcaaga ccttcatcaa ccacacccag 2580 ggcatccccg acttcttcaa gcagtccttc cctgagggct tcacatggga gagagtcacc 2640 acatacgaag acgggggcgt gctgaccgct acccaggaca ccagcctcca ggacggctgc 2700 ctcatctaca acgtcaagat cagaggggtg aacttcacat ccaacggccc tgtgatgcag 2760 aagaaaacac tcggctggga ggccttcacc gagacgctgt accccgctga cggcggcctg 2820 gaaggcagaa acgacatggc cctgaagctc gtgggcggga gccatctgat cgcaaacatc 2880 aagaccacat atagatccaa gaaacccgct aagaacctca agatgcctgg cgtctactat 2940 gtggactaca gactggaaag aatcaaggag gccaacaacg agacctacgt cgagcagcac 3000 gaggtggcag tggccagata ctgcgacctc cctagcaaac tggggcacaa gcttaattaa 3060 caccggtggc gcgttaagtc gacaatcaac ctctggatta caaaatttgt gaaagattga 3120 ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt 3180 tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt 3240 tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg 3300 tgtttgctga cgcaaccccc actggttggg gcattgccac cacctgtcag ctcctttccg 3360 ggactttcgc tttccccctc cctattgcca cggcggaact catcgccgcc tgccttgccc 3420 gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgttg tcggggaaat 3480 catcgtcctt tccttggctg ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct 3540 tctgctacgt cccttcggcc ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg 3600 ctctgcggcc tcttccgcgt cttcgccttc gccctcagac gagtcggatc tccctttggg 3660 ccgcctcccc gcgtcgactt taagaccaat gacttacaag gcagctgtag atcttagcca 3720 ctttttaaaa gaaaaggggg gactggaagg gctaattcac tcccaacgaa gacaagatct 3780 gctttttgct tgtactgggt ctctctggtt agaccagatc tgagcctggg agctctctgg 3840 ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt 3900 gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct tttagtcagt 3960 gtggaaaatc tctagcagta cgtatagtag ttcatgtcat cttattattc agtatttata 4020 acttgcaaag aaatgaatat cagagagtga gaggaacttg tttattgcag cttataatgg 4080 ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc 4140 tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggctct agctatcccg 4200 cccctaactc cgcccatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat 4260 ggctgactaa ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc 4320 cagaagtagt gaggaggctt ttttggaggc ctagggacgt acccaattcg ccctatagtg 4380 agtcgtatta cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg 4440 gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg 4500 aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg 4560 cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta 4620 cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt 4680 tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg 4740 ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat 4800 cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac 4860 tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag 4920 ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg 4980 cgaattttaa caaaatatta acgcttacaa tttaggtggc acttttcggg gaaatgtgcg 5040 cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca 5100 ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt 5160 ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga 5220 aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga 5280 actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat 5340 gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca 5400 agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt 5460 cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac 5520 catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct 5580 aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga 5640 gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac 5700 aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat 5760 agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg 5820 ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc 5880 actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc 5940 aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg 6000 gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta 6060 atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg 6120 tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga 6180 tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt 6240 ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag 6300 agcgcagata ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa 6360 ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag 6420 tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca 6480 gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac 6540 cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa 6600 ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc 6660 agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg 6720 tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc 6780 ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc 6840 ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag 6900 ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa 6960 accgcctctc cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca ggtttcccga 7020 ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt tagctcactc attaggcacc 7080 ccaggcttta cactttatgc ttccggctcg tatgttgtgt ggaattgtga gcggataaca 7140 atttcacaca ggaaacagct atgaccatga ttacgccaag cgcgcaatta accctcacta 7200 aagggaacaa aagctggagc tgcaagctta atgtagtctt atgcaatact cttgtagtct 7260 tgcaacatgg taacgatgag ttagcaacat gccttacaag gagagaaaaa gcaccgtgca 7320 tgccgattgg tggaagtaag gtggtacgat cgtgccttat taggaaggca acagacgggt 7380 ctgacatgga ttggacgaac cactgaattg ccgcattgca gagatattgt atttaagtgc 7440 ctagctcgat acataaacgg gtctctctgg ttagaccaga tctgagcctg ggagctctct 7500 ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt gcttcaagta 7560 gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc cttttagtca 7620 gtgtggaaaa tctctagcag tggcgcccga acagggactt gaaagcgaaa gggaaaccag 7680 aggagctctc tcgacgcagg actcggcttg ctgaagcgcg cacggcaaga ggcgaggggc 7740 ggcgactggt gagtacgcca aaaattttga ctagcggagg ctagaaggag agagatgggt 7800 gcgagagcgt cagtattaag cgggggagaa ttagatcgcg atgggaaaaa attcggttaa 7860 ggccaggggg aaagaaaaaa tataaattaa aacatatagt atgggcaagc agggagctag 7920 aacgattcgc agttaatcct ggcctgttag aaacatcaga aggctgtaga caaatactgg 7980 gacagctaca accatccctt cagacaggat cagaagaact tagatcatta tataatacag 8040 tagcaaccct ctattgtgtg catcaaagga tagagataaa agacaccaag gaagctttag 8100 acaagataga ggaagagcaa aacaaaagta agaccaccgc acagcaagcg gccgctgatc 8160 ttcagacctg gaggaggaga tatgagggac aattggagaa gtgaattata taaatataaa 8220 gtagtaaaaa ttgaaccatt aggagtagca cccaccaagg caaagagaag agtggtgcag 8280 agagaaaaaa gagcagtggg aataggagct ttgttccttg ggttcttggg agcagcagga 8340 agcactatgg gcgcagcgtc aatgacgctg acggtacagg ccagacaatt attgtctggt 8400 atagtgcagc agcagaacaa tttgctgagg gctattgagg cgcaacagca tctgttgcaa 8460 ctcacagtct ggggcatcaa gcagctccag gcaagaatcc tggctgtgga aagataccta 8520 aaggatcaac agctcctggg gatttggggt tgctctggaa aactcatttg caccactgct 8580 gtgccttgga atgctagttg gagtaataaa tctctggaac agatttggaa tcacacgacc 8640 tggatggagt gggacagaga aattaacaat tacacaagct taatacactc cttaattgaa 8700 gaatcgcaaa accagcaaga aaagaatgaa caagaattat tggaattaga taaatgggca 8760 agtttgtgga attggtttaa cataacaaat tggctgtggt atataaaatt attcataatg 8820 atagtaggag gcttggtagg tttaagaata gtttttgctg tactttctat agtgaataga 8880 gttaggcagg gatattcacc attatcgttt cagacccacc tcccaacccc gaggggaccc 8940 ttgcgccttt tccaaggcag ccctgggttt gcgcagggac gcggctgctc tgggcgtggt 9000 tccgggaaac gcagcggcgc cgaccctggg tctcgcacat tcttcacgtc cgttcgcagc 9060 gtcacccgga tcttcgccgc tacccttgtg ggccccccgg cgacgcttcc tgctccgccc 9120 ctaagtcggg aaggttcctt gcggttcgcg gcgtgccgga cgtgacaaac ggaagccgca 9180 cgtctcacta gtaccctcgc agacggacag cgccagggag caatggcagc gcgccgaccg 9240 cgatgggctg tggccaatag cggctgctca gcagggcgcg ccgagagcag cggccgggaa 9300 ggggcggtgc gggaggcggg gtgtggggcg gtagtgtggg ccctgttcct gcccgcgcgg 9360 tgttccgcat tctgcaagcc tccggagcgc acgtcggcag tcggctccct cgttgaccga 9420 atcaccgacc tctctcccca gggggtaccc agctgtctag agaattctag atcttgagac 9480 aaatggcagt attcatccac aattttaaaa gaaaaggggg gattgggggg tacagtgcag 9540 gggaaagaat agtagacata atagcaacag acatacaaac taaagaatta caaaaacaaa 9600 ttacaaaaat tcaaaatttt cgggtttatt acagggacag cagagatcca ctttggcgcc 9660 ggctcgaggg gg 9672 <210> 33 <211> 342 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 33 Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe Leu Ile 1 5 10 15 Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 20 25 30 Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 35 40 45 Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 50 55 60 Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 65 70 75 80 Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala Gln 85 90 95 Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu 100 105 110 Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser 115 120 125 Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr 130 135 140 Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr 145 150 155 160 His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln 165 170 175 Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg 180 185 190 His Leu Val His Ala Asp Phe Gly Ser Asn Asn Val Leu Thr Asp Asn 195 200 205 Gly Arg Ile Thr Ala Val Ile Asp Trp Ser Glu Ala Met Phe Gly Asp 210 215 220 Ser Gln Tyr Glu Val Ala Asn Ile Phe Phe Trp Arg Pro Trp Leu Ala 225 230 235 240 Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu 245 250 255 Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 260 265 270 Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 275 280 285 Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 290 295 300 Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 305 310 315 320 Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 325 330 335 Val Asp Asn Leu Pro Asn 340 <210> 34 <211> 9063 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 34 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cgtaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgtatggagc agcagacgcg ctacttcgag 780 cggaggcatc cggagcttgc aggatcgccg cggctccggg cgtatatgct ccgcattggt 840 cttgaccaac tctatcagag cttggttgac ggcaatttcg atgatgcagc ttgggcgcag 900 ggtcgatgcg acgcaatcgt ccgatccgga gccgggactg tcgggcgtac acaaatcgcc 960 cgcagaagcg cggccgtctg gaccgatggc tgtgtagaag tactcgccga tagtggaaac 1020 cgacgcccca gcactcgtcc gagggcaaag gaatagttaa ttaagaattc gacccagctt 1080 tcttgtacaa agtggttggt aagcctatcc ctaaccctct cctcggtctc gattctacgt 1140 agtaatgagc tagcagtctc gaggttaacg aattccgccc cccccctaac gttactggcc 1200 gaagccgctt ggaataaggc cggtgtgcgc ttgtctatat gttattttcc accatattgc 1260 cgtcttttgg caatgtgagg gcccggaaac ctggccctgt cttcttgacg agcattccta 1320 ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg aaggaagcag 1380 ttcctctgga agcttcttga agacaaacaa cgtctgtagc gaccctttgc aggcagcgga 1440 accccccacc tggcgacagg tgcccctgcg gccaaaagcc acgtgtataa gatacacctg 1500 caaaggcggc acaaccccag tgccacgttg tgagttggat agttgtggaa agagtcaaat 1560 ggctctcctc aagcgtattc aacaaggggc tgaaggatgc ccagaaggta ccccattgta 1620 tgggatctga tctggggcct cggtgcacat gctttacatg tgtttagtcg aggttaaaaa 1680 aacgtctagg ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgataatacc 1740 atggtgagca agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag 1800 gtgcacatgg agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc 1860 cgcccctacg agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc 1920 ttcgcctggg acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac 1980 cccgccgaca tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc 2040 gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc aggactcctc cctgcaggac 2100 ggcgagttca tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta 2160 atgcagaaga agaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc 2220 gccctgaagg gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct 2280 gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc 2340 aacatcaagt tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa 2400 cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaagta acaccggtgg 2460 cgcgttaagt cgacaatcaa cctctggatt acaaaatttg tgaaagattg actggtattc 2520 ttaactatgt tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg 2580 ctattgcttc ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc 2640 tttatgagga gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg 2700 acgcaacccc cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg 2760 ctttccccct ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga 2820 caggggctcg gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct 2880 ttccttggct gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg 2940 tcccttcggc cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc 3000 ctcttccgcg tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc 3060 cgcgtcgact ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa 3120 agaaaagggg ggactggaag ggctaattca ctcccaacga agacaagatc tgctttttgc 3180 ttgtactggg tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg 3240 gaacccactg cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg 3300 tctgttgtgt gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat 3360 ctctagcagt acgtatagta gttcatgtca tcttattatt cagtatttat aacttgcaaa 3420 gaaatgaata tcagagagtg agaggaactt gtttattgca gcttataatg gttacaaata 3480 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 3540 tttgtccaaa ctcatcaatg tatcttatca tgtctggctc tagctatccc gcccctaact 3600 ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta 3660 atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt ccagaagtag 3720 tgaggaggct tttttggagg cctagggacg tacccaattc gccctatagt gagtcgtatt 3780 acgcgcgctc actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc 3840 aacttaatcg ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc 3900 gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatgggac gcgccctgta 3960 gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca 4020 gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct 4080 ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc 4140 acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat 4200 agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc 4260 aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc 4320 cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta 4380 acaaaatatt aacgcttaca atttaggtgg cacttttcgg ggaaatgtgc gcggaacccc 4440 tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg 4500 ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc 4560 ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt 4620 gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct 4680 caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac 4740 ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact 4800 cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa 4860 gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga 4920 taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt 4980 tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga 5040 agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg 5100 caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat 5160 ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat 5220 tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc 5280 agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga 5340 tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc 5400 agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag 5460 gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc 5520 gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt 5580 tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt 5640 gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat 5700 accaaatact gttcttctag tgtagccgta gttaggccac cacttcaaga actctgtagc 5760 accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa 5820 gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg 5880 ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag 5940 atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag 6000 gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa 6060 cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt 6120 gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg 6180 gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc 6240 tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac 6300 cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct 6360 ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc 6420 gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt 6480 acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac 6540 aggaaacagc tatgaccatg attacgccaa gcgcgcaatt aaccctcact aaagggaaca 6600 aaagctggag ctgcaagctt aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg 6660 gtaacgatga gttagcaaca tgccttacaa ggagagaaaa agcaccgtgc atgccgattg 6720 gtggaagtaa ggtggtacga tcgtgcctta ttaggaaggc aacagacggg tctgacatgg 6780 attggacgaa ccactgaatt gccgcattgc agagatattg tatttaagtg cctagctcga 6840 tacataaacg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta 6900 gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc 6960 cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa 7020 atctctagca gtggcgcccg aacagggact tgaaagcgaa agggaaacca gaggagctct 7080 ctcgacgcag gactcggctt gctgaagcgc gcacggcaag aggcgagggg cggcgactgg 7140 tgagtacgcc aaaaattttg actagcggag gctagaagga gagagatggg tgcgagagcg 7200 tcagtattaa gcgggggaga attagatcgc gatgggaaaa aattcggtta aggccagggg 7260 gaaagaaaaa atataaatta aaacatatag tatgggcaag cagggagcta gaacgattcg 7320 cagttaatcc tggcctgtta gaaacatcag aaggctgtag acaaatactg ggacagctac 7380 aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca gtagcaaccc 7440 tctattgtgt gcatcaaagg atagagataa aagacaccaa ggaagcttta gacaagatag 7500 aggaagagca aaacaaaagt aagaccaccg cacagcaagc ggccgctgat cttcagacct 7560 ggaggaggag atatgaggga caattggaga agtgaattat ataaatataa agtagtaaaa 7620 attgaaccat taggagtagc acccaccaag gcaaagagaa gagtggtgca gagagaaaaa 7680 agagcagtgg gaataggagc tttgttcctt gggttcttgg gagcagcagg aagcactatg 7740 ggcgcagcgt caatgacgct gacggtacag gccagacaat tattgtctgg tatagtgcag 7800 cagcagaaca atttgctgag ggctattgag gcgcaacagc atctgttgca actcacagtc 7860 tggggcatca agcagctcca ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa 7920 cagctcctgg ggatttgggg ttgctctgga aaactcattt gcaccactgc tgtgccttgg 7980 aatgctagtt ggagtaataa atctctggaa cagatttgga atcacacgac ctggatggag 8040 tgggacagag aaattaacaa ttacacaagc ttaatacact ccttaattga agaatcgcaa 8100 aaccagcaag aaaagaatga acaagaatta ttggaattag ataaatgggc aagtttgtgg 8160 aattggttta acataacaaa ttggctgtgg tatataaaat tattcataat gatagtagga 8220 ggcttggtag gtttaagaat agtttttgct gtactttcta tagtgaatag agttaggcag 8280 ggatattcac cattatcgtt tcagacccac ctcccaaccc cgaggggacc cttgcgcctt 8340 ttccaaggca gccctgggtt tgcgcaggga cgcggctgct ctgggcgtgg ttccgggaaa 8400 cgcagcggcg ccgaccctgg gtctcgcaca ttcttcacgt ccgttcgcag cgtcacccgg 8460 atcttcgccg ctacccttgt gggccccccg gcgacgcttc ctgctccgcc cctaagtcgg 8520 gaaggttcct tgcggttcgc ggcgtgccgg acgtgacaaa cggaagccgc acgtctcact 8580 agtaccctcg cagacggaca gcgccaggga gcaatggcag cgcgccgacc gcgatgggct 8640 gtggccaata gcggctgctc agcagggcgc gccgagagca gcggccggga aggggcggtg 8700 cgggaggcgg ggtgtggggc ggtagtgtgg gccctgttcc tgcccgcgcg gtgttccgca 8760 ttctgcaagc ctccggagcg cacgtcggca gtcggctccc tcgttgaccg aatcaccgac 8820 ctctctcccc agggggtacc cagctgtcta gagaattcta gatcttgaga caaatggcag 8880 tattcatcca caattttaaa agaaaagggg ggattggggg gtacagtgca ggggaaagaa 8940 tagtagacat aatagcaaca gacatacaaa ctaaagaatt acaaaaacaa attacaaaaa 9000 ttcaaaattt tcgggtttat tacagggaca gcagagatcc actttggcgc cggctcgagg 9060 ggg 9063 <210> 35 <211> 137 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 35 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Met Glu Gln Gln Thr Arg Tyr Phe Glu Arg Arg 35 40 45 His Pro Glu Leu Ala Gly Ser Pro Arg Leu Arg Ala Tyr Met Leu Arg 50 55 60 Ile Gly Leu Asp Gln Leu Tyr Gln Ser Leu Val Asp Gly Asn Phe Asp 65 70 75 80 Asp Ala Ala Trp Ala Gln Gly Arg Cys Asp Ala Ile Val Arg Ser Gly 85 90 95 Ala Gly Thr Val Gly Arg Thr Gln Ile Ala Arg Arg Ser Ala Ala Val 100 105 110 Trp Thr Asp Gly Cys Val Glu Val Leu Ala Asp Ser Gly Asn Arg Arg 115 120 125 Pro Ser Thr Arg Pro Arg Ala Lys Glu 130 135 <210> 36 <211> 9828 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 36 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgacacca tgaaaaagcc tgaactcacc 660 gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 720 ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc 780 ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt 840 gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaatttag cgagagcctg 900 acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa 960 ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt 1020 agccagacga gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg 1080 cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac tgtgatggac 1140 gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc tgatgctttg ggccgaggac 1200 tgccccgaag tccggcacct cgtgcacgcg gatttcggct ccaacaatgt cctgacggac 1260 aatggccgca taacagcggt cattgactgg agcgaggcga tgttcgggga ttcccaatac 1320 gaggtcgcca acatcttctt ctggaggccg tggttggctt gtatggagca gcagacgcgc 1380 tacttcgagc ggaggcatcc ggagcttgca ggatcgccgc ggctccgggc gtatatgctc 1440 cgcattggtc ttgaccaact ctatcagagc ttggttgacg gcaatttcga tgatgcagct 1500 tgggcgcagg gtcgatgcct ttcatacgag accgagatcc tgactgtcga gtacggattg 1560 cttcctatcg gcaaaatcgt ggagaagagg attgaatgta ccgtctattc agtcgataat 1620 aatgggaaca tctacacaca gcccgtggct caatggcacg acagaggaga gcaggaagtt 1680 tttgaatact gtctcgagga cggatccctc atccgcgcta ctaaagatca taagtttatg 1740 accgtggacg gccagatgct gccaattgac gaaatttttg aacgagagct ggatctgatg 1800 agagtcgaca accttccaaa ctgattaatt aagaattcga cccagctttc ttgtacaaag 1860 tggttggtaa gcctatccct aaccctctcc tcggtctcga ttctacgtag taatgagcta 1920 gcagtctcga ggttaacgaa ttccgccccc cccctaacgt tactggccga agccgcttgg 1980 aataaggccg gtgtgcgctt gtctatatgt tattttccac catattgccg tcttttggca 2040 atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg ggtctttccc 2100 ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt cctctggaag 2160 cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac cccccacctg 2220 gcgacaggtg cccctgcggc caaaagccac gtgtataaga tacacctgca aaggcggcac 2280 aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg ctctcctcaa 2340 gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg ggatctgatc 2400 tggggcctcg gtgcacatgc tttacatgtg tttagtcgag gttaaaaaaa cgtctaggcc 2460 ccccgaacca cggggacgtg gttttccttt gaaaaacacg ataataccat ggccatgagc 2520 gagctgatta aggagaacat gcacatgaag ctgtacatgg agggcaccgt ggacaaccat 2580 cacttcaagt gcacatccga gggcgaaggc aagccctacg agggcaccca gaccatgaga 2640 atcaaggtgg tcgagggcgg ccctctcccc ttcgccttcg acatcctggc tactagcttc 2700 ctctacggca gcaagacctt catcaaccac acccagggca tccccgactt cttcaagcag 2760 tccttccctg agggcttcac atgggagaga gtcaccacat acgaagacgg gggcgtgctg 2820 accgctaccc aggacaccag cctccaggac ggctgcctca tctacaacgt caagatcaga 2880 ggggtgaact tcacatccaa cggccctgtg atgcagaaga aaacactcgg ctgggaggcc 2940 ttcaccgaga cgctgtaccc cgctgacggc ggcctggaag gcagaaacga catggccctg 3000 aagctcgtgg gcgggagcca tctgatcgca aacatcaaga ccacatatag atccaagaaa 3060 cccgctaaga acctcaagat gcctggcgtc tactatgtgg actacagact ggaaagaatc 3120 aaggaggcca acaacgagac ctacgtcgag cagcacgagg tggcagtggc cagatactgc 3180 gacctcccta gcaaactggg gcacaagctt aattaacacc ggtggcgcgt taagtcgaca 3240 atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc 3300 cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta 3360 tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt 3420 ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg 3480 gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta 3540 ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt 3600 tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg 3660 cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca 3720 atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc 3780 gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgcgt cgactttaag 3840 accaatgact tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact 3900 ggaagggcta attcactccc aacgaagaca agatctgctt tttgcttgta ctgggtctct 3960 ctggttagac cagatctgag cctgggagct ctctggctaa ctagggaacc cactgcttaa 4020 gcctcaataa agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc 4080 tggtaactag agatccctca gaccctttta gtcagtgtgg aaaatctcta gcagtacgta 4140 tagtagttca tgtcatctta ttattcagta tttataactt gcaaagaaat gaatatcaga 4200 gagtgagagg aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac 4260 aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat 4320 caatgtatct tatcatgtct ggctctagct atcccgcccc taactccgcc catcccgccc 4380 ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat 4440 gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg aggctttttt 4500 ggaggcctag ggacgtaccc aattcgccct atagtgagtc gtattacgcg cgctcactgg 4560 ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 4620 cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 4680 cccaacagtt gcgcagcctg aatggcgaat gggacgcgcc ctgtagcggc gcattaagcg 4740 cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg 4800 ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc 4860 taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa 4920 aacttgatta gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc 4980 ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac 5040 tcaaccctat ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt 5100 ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa atattaacgc 5160 ttacaattta ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt 5220 ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata 5280 atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt 5340 tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc 5400 tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat 5460 ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct 5520 atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc gccgcataca 5580 ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg 5640 catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa 5700 cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg 5760 ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga 5820 cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg 5880 cgaactactt actctagctt cccggcaaca attaatagac tggatggagg cggataaagt 5940 tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg 6000 agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc 6060 ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca 6120 gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc 6180 atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat 6240 cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc 6300 agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg 6360 ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct 6420 accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa atactgttct 6480 tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct 6540 cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg 6600 gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc 6660 gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga 6720 gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg 6780 cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta 6840 tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg 6900 ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg 6960 ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat 7020 taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc 7080 agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg cgcgttggcc 7140 gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa 7200 cgcaattaat gtgagttagc tcactcatta ggcaccccag gctttacact ttatgcttcc 7260 ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa acagctatga 7320 ccatgattac gccaagcgcg caattaaccc tcactaaagg gaacaaaagc tggagctgca 7380 agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag 7440 caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg 7500 tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact 7560 gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacat aaacgggtct 7620 ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt 7680 aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac 7740 tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc 7800 gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc 7860 ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa 7920 ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg 7980 ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata 8040 aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc 8100 tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga 8160 caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc 8220 aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca 8280 aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg 8340 agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga 8400 gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata 8460 ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg 8520 acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg 8580 ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag 8640 ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt 8700 tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt 8760 aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt 8820 aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag 8880 aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata 8940 acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta 9000 agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta 9060 tcgtttcaga cccacctccc aaccccgagg ggacccttgc gccttttcca aggcagccct 9120 gggtttgcgc agggacgcgg ctgctctggg cgtggttccg ggaaacgcag cggcgccgac 9180 cctgggtctc gcacattctt cacgtccgtt cgcagcgtca cccggatctt cgccgctacc 9240 cttgtgggcc ccccggcgac gcttcctgct ccgcccctaa gtcgggaagg ttccttgcgg 9300 ttcgcggcgt gccggacgtg acaaacggaa gccgcacgtc tcactagtac cctcgcagac 9360 ggacagcgcc agggagcaat ggcagcgcgc cgaccgcgat gggctgtggc caatagcggc 9420 tgctcagcag ggcgcgccga gagcagcggc cgggaagggg cggtgcggga ggcggggtgt 9480 ggggcggtag tgtgggccct gttcctgccc gcgcggtgtt ccgcattctg caagcctccg 9540 gagcgcacgt cggcagtcgg ctccctcgtt gaccgaatca ccgacctctc tccccagggg 9600 gtacccagct gtctagagaa ttctagatct tgagacaaat ggcagtattc atccacaatt 9660 ttaaaagaaa aggggggatt ggggggtaca gtgcagggga aagaatagta gacataatag 9720 caacagacat acaaactaaa gaattacaaa aacaaattac aaaaattcaa aattttcggg 9780 tttattacag ggacagcaga gatccacttt ggcgccggct cgaggggg 9828 <210> 37 <211> 394 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 37 Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe Leu Ile 1 5 10 15 Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 20 25 30 Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 35 40 45 Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 50 55 60 Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 65 70 75 80 Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala Gln 85 90 95 Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu 100 105 110 Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser 115 120 125 Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr 130 135 140 Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr 145 150 155 160 His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln 165 170 175 Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg 180 185 190 His Leu Val His Ala Asp Phe Gly Ser Asn Asn Val Leu Thr Asp Asn 195 200 205 Gly Arg Ile Thr Ala Val Ile Asp Trp Ser Glu Ala Met Phe Gly Asp 210 215 220 Ser Gln Tyr Glu Val Ala Asn Ile Phe Phe Trp Arg Pro Trp Leu Ala 225 230 235 240 Cys Met Glu Gln Gln Thr Arg Tyr Phe Glu Arg Arg His Pro Glu Leu 245 250 255 Ala Gly Ser Pro Arg Leu Arg Ala Tyr Met Leu Arg Ile Gly Leu Asp 260 265 270 Gln Leu Tyr Gln Ser Leu Val Asp Gly Asn Phe Asp Asp Ala Ala Trp 275 280 285 Ala Gln Gly Arg Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu 290 295 300 Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys 305 310 315 320 Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val 325 330 335 Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu 340 345 350 Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr 355 360 365 Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu 370 375 380 Asp Leu Met Arg Val Asp Asn Leu Pro Asn 385 390 <210> 38 <211> 8907 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 38 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcgacgcaa tcgtccgatc cggagccggg 780 actgtcgggc gtacacaaat cgcccgcaga agcgcggccg tctggaccga tggctgtgta 840 gaagtactcg ccgatagtgg aaaccgacgc cccagcactc gtccgagggc aaaggaatag 900 ttaattaaga attcgaccca gctttcttgt acaaagtggt tggtaagcct atccctaacc 960 ctctcctcgg tctcgattct acgtagtaat gagctagcag tctcgaggtt aacgaattcc 1020 gccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt gcgcttgtct 1080 atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc 1140 ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc 1200 tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg 1260 tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcccc tgcggccaaa 1320 agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt 1380 ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg 1440 atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta 1500 catgtgttta gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt 1560 tcctttgaaa aacacgataa taccatggtg agcaagggcg aggaggataa catggccatc 1620 atcaaggagt tcatgcgctt caaggtgcac atggagggct ccgtgaacgg ccacgagttc 1680 gagatcgagg gcgagggcga gggccgcccc tacgagggca cccagaccgc caagctgaag 1740 gtgaccaagg gtggccccct gcccttcgcc tgggacatcc tgtcccctca gttcatgtac 1800 ggctccaagg cctacgtgaa gcaccccgcc gacatccccg actacttgaa gctgtccttc 1860 cccgagggct tcaagtggga gcgcgtgatg aacttcgagg acggcggcgt ggtgaccgtg 1920 acccaggact cctccctgca ggacggcgag ttcatctaca aggtgaagct gcgcggcacc 1980 aacttcccct ccgacggccc cgtaatgcag aagaagacca tgggctggga ggcctcctcc 2040 gagcggatgt accccgagga cggcgccctg aagggcgaga tcaagcagag gctgaagctg 2100 aaggacggcg gccactacga cgctgaggtc aagaccacct acaaggccaa gaagcccgtg 2160 cagctgcccg gcgcctacaa cgtcaacatc aagttggaca tcacctccca caacgaggac 2220 tacaccatcg tggaacagta cgaacgcgcc gagggccgcc actccaccgg cggcatggac 2280 gagctgtaca agtaacaccg gtggcgcgtt aagtcgacaa tcaacctctg gattacaaaa 2340 tttgtgaaag attgactggt attcttaact atgttgctcc ttttacgcta tgtggatacg 2400 ctgctttaat gcctttgtat catgctattg cttcccgtat ggctttcatt ttctcctcct 2460 tgtataaatc ctggttgctg tctctttatg aggagttgtg gcccgttgtc aggcaacgtg 2520 gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg ttggggcatt gccaccacct 2580 gtcagctcct ttccgggact ttcgctttcc ccctccctat tgccacggcg gaactcatcg 2640 ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt gggcactgac aattccgtgg 2700 tgttgtcggg gaaatcatcg tcctttcctt ggctgctcgc ctgtgttgcc acctggattc 2760 tgcgcgggac gtccttctgc tacgtccctt cggccctcaa tccagcggac cttccttccc 2820 gcggcctgct gccggctctg cggcctcttc cgcgtcttcg ccttcgccct cagacgagtc 2880 ggatctccct ttgggccgcc tccccgcgtc gactttaaga ccaatgactt acaaggcagc 2940 tgtagatctt agccactttt taaaagaaaa ggggggactg gaagggctaa ttcactccca 3000 acgaagacaa gatctgcttt ttgcttgtac tgggtctctc tggttagacc agatctgagc 3060 ctgggagctc tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg 3120 agtgcttcaa gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag 3180 acccttttag tcagtgtgga aaatctctag cagtacgtat agtagttcat gtcatcttat 3240 tattcagtat ttataacttg caaagaaatg aatatcagag agtgagagga acttgtttat 3300 tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 3360 tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg 3420 gctctagcta tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc 3480 cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg 3540 gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg gacgtaccca 3600 attcgcccta tagtgagtcg tattacgcgc gctcactggc cgtcgtttta caacgtcgtg 3660 actgggaaaa ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca 3720 gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga 3780 atggcgaatg ggacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc 3840 gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt 3900 cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag 3960 ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt 4020 cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt 4080 tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt 4140 cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt 4200 aacaaaaatt taacgcgaat tttaacaaaa tattaacgct tacaatttag gtggcacttt 4260 tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta 4320 tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat 4380 gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt 4440 ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg 4500 agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga 4560 agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg 4620 tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt 4680 tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg 4740 cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg 4800 aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga 4860 tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc 4920 tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc 4980 ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc 5040 ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg 5100 cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac 5160 gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc 5220 actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt 5280 aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac 5340 caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa 5400 aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc 5460 accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt 5520 aactggcttc agcagagcgc agataccaaa tactgttctt ctagtgtagc cgtagttagg 5580 ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc 5640 agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt 5700 accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga 5760 gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct 5820 tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg 5880 cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca 5940 cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa 6000 cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt 6060 ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga 6120 taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga 6180 gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca 6240 cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg tgagttagct 6300 cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt tgtgtggaat 6360 tgtgagcgga taacaatttc acacaggaaa cagctatgac catgattacg ccaagcgcgc 6420 aattaaccct cactaaaggg aacaaaagct ggagctgcaa gcttaatgta gtcttatgca 6480 atactcttgt agtcttgcaa catggtaacg atgagttagc aacatgcctt acaaggagag 6540 aaaaagcacc gtgcatgccg attggtggaa gtaaggtggt acgatcgtgc cttattagga 6600 aggcaacaga cgggtctgac atggattgga cgaaccactg aattgccgca ttgcagagat 6660 attgtattta agtgcctagc tcgatacata aacgggtctc tctggttaga ccagatctga 6720 gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct 6780 tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc 6840 agaccctttt agtcagtgtg gaaaatctct agcagtggcg cccgaacagg gacttgaaag 6900 cgaaagggaa accagaggag ctctctcgac gcaggactcg gcttgctgaa gcgcgcacgg 6960 caagaggcga ggggcggcga ctggtgagta cgccaaaaat tttgactagc ggaggctaga 7020 aggagagaga tgggtgcgag agcgtcagta ttaagcgggg gagaattaga tcgcgatggg 7080 aaaaaattcg gttaaggcca gggggaaaga aaaaatataa attaaaacat atagtatggg 7140 caagcaggga gctagaacga ttcgcagtta atcctggcct gttagaaaca tcagaaggct 7200 gtagacaaat actgggacag ctacaaccat cccttcagac aggatcagaa gaacttagat 7260 cattatataa tacagtagca accctctatt gtgtgcatca aaggatagag ataaaagaca 7320 ccaaggaagc tttagacaag atagaggaag agcaaaacaa aagtaagacc accgcacagc 7380 aagcggccgc tgatcttcag acctggagga ggagatatga gggacaattg gagaagtgaa 7440 ttatataaat ataaagtagt aaaaattgaa ccattaggag tagcacccac caaggcaaag 7500 agaagagtgg tgcagagaga aaaaagagca gtgggaatag gagctttgtt ccttgggttc 7560 ttgggagcag caggaagcac tatgggcgca gcgtcaatga cgctgacggt acaggccaga 7620 caattattgt ctggtatagt gcagcagcag aacaatttgc tgagggctat tgaggcgcaa 7680 cagcatctgt tgcaactcac agtctggggc atcaagcagc tccaggcaag aatcctggct 7740 gtggaaagat acctaaagga tcaacagctc ctggggattt ggggttgctc tggaaaactc 7800 atttgcacca ctgctgtgcc ttggaatgct agttggagta ataaatctct ggaacagatt 7860 tggaatcaca cgacctggat ggagtgggac agagaaatta acaattacac aagcttaata 7920 cactccttaa ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga attattggaa 7980 ttagataaat gggcaagttt gtggaattgg tttaacataa caaattggct gtggtatata 8040 aaattattca taatgatagt aggaggcttg gtaggtttaa gaatagtttt tgctgtactt 8100 tctatagtga atagagttag gcagggatat tcaccattat cgtttcagac ccacctccca 8160 accccgaggg gacccttgcg ccttttccaa ggcagccctg ggtttgcgca gggacgcggc 8220 tgctctgggc gtggttccgg gaaacgcagc ggcgccgacc ctgggtctcg cacattcttc 8280 acgtccgttc gcagcgtcac ccggatcttc gccgctaccc ttgtgggccc cccggcgacg 8340 cttcctgctc cgcccctaag tcgggaaggt tccttgcggt tcgcggcgtg ccggacgtga 8400 caaacggaag ccgcacgtct cactagtacc ctcgcagacg gacagcgcca gggagcaatg 8460 gcagcgcgcc gaccgcgatg ggctgtggcc aatagcggct gctcagcagg gcgcgccgag 8520 agcagcggcc gggaaggggc ggtgcgggag gcggggtgtg gggcggtagt gtgggccctg 8580 ttcctgcccg cgcggtgttc cgcattctgc aagcctccgg agcgcacgtc ggcagtcggc 8640 tccctcgttg accgaatcac cgacctctct ccccaggggg tacccagctg tctagagaat 8700 tctagatctt gagacaaatg gcagtattca tccacaattt taaaagaaaa ggggggattg 8760 gggggtacag tgcaggggaa agaatagtag acataatagc aacagacata caaactaaag 8820 aattacaaaa acaaattaca aaaattcaaa attttcgggt ttattacagg gacagcagag 8880 atccactttg gcgccggctc gaggggg 8907 <210> 39 <211> 85 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 39 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Asp Ala Ile Val Arg Ser Gly Ala Gly Thr Val 35 40 45 Gly Arg Thr Gln Ile Ala Arg Arg Ser Ala Ala Val Trp Thr Asp Gly 50 55 60 Cys Val Glu Val Leu Ala Asp Ser Gly Asn Arg Arg Pro Ser Thr Arg 65 70 75 80 Pro Arg Ala Lys Glu 85 <210> 40 <211> 9261 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 40 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgaaaac atttaacatt 660 tctcaacagg atctagaatt agtagaagta gcgacagaga agattacaat gctttatgag 720 gataataaac atcatgtggg agcggcaatt cgtacgaaaa caggagaaat catttcggca 780 gtacatattg aagcgtatat aggacgagta actgtttgtg cagaagccat tgcgattggt 840 agtgcagttt cgaatggaca aaaggatttt gacacgattg tagctgttag acacccttat 900 tctgacgaag tagatagaag tattcgagtg gtaagtcctt gtggtatgtg cctttcatac 960 gagaccgaga tcctgactgt cgagtacgga ttgcttccta tcggcaaaat cgtggagaag 1020 aggattgaat gtaccgtcta ttcagtcgat aataatggga acatctacac acagcccgtg 1080 gctcaatggc acgacagagg agagcaggaa gtttttgaat actgtctcga ggacggatcc 1140 ctcatccgcg ctactaaaga tcataagttt atgaccgtgg acggccagat gctgccaatt 1200 gacgaaattt ttgaacgaga gctggatctg atgagagtcg acaaccttcc aaactgatta 1260 attaagaatt cgacccagct ttcttgtaca aagtggttgg taagcctatc cctaaccctc 1320 tcctcggtct cgattctacg tagtaatgag ctagcagtct cgaggttaac gaattccgcc 1380 ccccccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg cttgtctata 1440 tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg 1500 tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg caaggtctgt 1560 tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca acgtctgtag 1620 cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcccctgc ggccaaaagc 1680 cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga 1740 tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg ctgaaggatg 1800 cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca tgctttacat 1860 gtgtttagtc gaggttaaaa aaacgtctag gccccccgaa ccacggggac gtggttttcc 1920 tttgaaaaac acgataatac catggccatg agcgagctga ttaaggagaa catgcacatg 1980 aagctgtaca tggagggcac cgtggacaac catcacttca agtgcacatc cgagggcgaa 2040 ggcaagccct acgagggcac ccagaccatg agaatcaagg tggtcgaggg cggccctctc 2100 cccttcgcct tcgacatcct ggctactagc ttcctctacg gcagcaagac cttcatcaac 2160 cacacccagg gcatccccga cttcttcaag cagtccttcc ctgagggctt cacatgggag 2220 agagtcacca catacgaaga cgggggcgtg ctgaccgcta cccaggacac cagcctccag 2280 gacggctgcc tcatctacaa cgtcaagatc agaggggtga acttcacatc caacggccct 2340 gtgatgcaga agaaaacact cggctgggag gccttcaccg agacgctgta ccccgctgac 2400 ggcggcctgg aaggcagaaa cgacatggcc ctgaagctcg tgggcgggag ccatctgatc 2460 gcaaacatca agaccacata tagatccaag aaacccgcta agaacctcaa gatgcctggc 2520 gtctactatg tggactacag actggaaaga atcaaggagg ccaacaacga gacctacgtc 2580 gagcagcacg aggtggcagt ggccagatac tgcgacctcc ctagcaaact ggggcacaag 2640 cttaattaac accggtggcg cgttaagtcg acaatcaacc tctggattac aaaatttgtg 2700 aaagattgac tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt 2760 taatgccttt gtatcatgct attgcttccc gtatggcttt cattttctcc tccttgtata 2820 aatcctggtt gctgtctctt tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg 2880 tgtgcactgt gtttgctgac gcaaccccca ctggttgggg cattgccacc acctgtcagc 2940 tcctttccgg gactttcgct ttccccctcc ctattgccac ggcggaactc atcgccgcct 3000 gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc gtggtgttgt 3060 cggggaaatc atcgtccttt ccttggctgc tcgcctgtgt tgccacctgg attctgcgcg 3120 ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc ggaccttcct tcccgcggcc 3180 tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg ccctcagacg agtcggatct 3240 ccctttgggc cgcctccccg cgtcgacttt aagaccaatg acttacaagg cagctgtaga 3300 tcttagccac tttttaaaag aaaagggggg actggaaggg ctaattcact cccaacgaag 3360 acaagatctg ctttttgctt gtactgggtc tctctggtta gaccagatct gagcctggga 3420 gctctctggc taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct 3480 tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt 3540 ttagtcagtg tggaaaatct ctagcagtac gtatagtagt tcatgtcatc ttattattca 3600 gtatttataa cttgcaaaga aatgaatatc agagagtgag aggaacttgt ttattgcagc 3660 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 3720 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggctcta 3780 gctatcccgc ccctaactcc gcccatcccg cccctaactc cgcccagttc cgcccattct 3840 ccgccccatg gctgactaat tttttttatt tatgcagagg ccgaggccgc ctcggcctct 3900 gagctattcc agaagtagtg aggaggcttt tttggaggcc tagggacgta cccaattcgc 3960 cctatagtga gtcgtattac gcgcgctcac tggccgtcgt tttacaacgt cgtgactggg 4020 aaaaccctgg cgttacccaa cttaatcgcc ttgcagcaca tccccctttc gccagctggc 4080 gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg 4140 aatgggacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg 4200 tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc 4260 tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc 4320 gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta 4380 gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta 4440 atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg 4500 atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa 4560 aatttaacgc gaattttaac aaaatattaa cgcttacaat ttaggtggca cttttcgggg 4620 aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct 4680 catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat 4740 tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc 4800 tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg 4860 ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg 4920 ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga 4980 cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta 5040 ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc 5100 tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc 5160 gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg 5220 ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc 5280 aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca 5340 acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct 5400 tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat 5460 cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg 5520 gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat 5580 taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact 5640 tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat 5700 cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc 5760 ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct 5820 accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg 5880 cttcagcaga gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca 5940 cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc 6000 tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga 6060 taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac 6120 gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga 6180 agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag 6240 ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg 6300 acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag 6360 caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc 6420 tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc 6480 tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc 6540 aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag 6600 gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca 6660 ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag 6720 cggataacaa tttcacacag gaaacagcta tgaccatgat tacgccaagc gcgcaattaa 6780 ccctcactaa agggaacaaa agctggagct gcaagcttaa tgtagtctta tgcaatactc 6840 ttgtagtctt gcaacatggt aacgatgagt tagcaacatg ccttacaagg agagaaaaag 6900 caccgtgcat gccgattggt ggaagtaagg tggtacgatc gtgccttatt aggaaggcaa 6960 cagacgggtc tgacatggat tggacgaacc actgaattgc cgcattgcag agatattgta 7020 tttaagtgcc tagctcgata cataaacggg tctctctggt tagaccagat ctgagcctgg 7080 gagctctctg gctaactagg gaacccactg cttaagcctc aataaagctt gccttgagtg 7140 cttcaagtag tgtgtgcccg tctgttgtgt gactctggta actagagatc cctcagaccc 7200 ttttagtcag tgtggaaaat ctctagcagt ggcgcccgaa cagggacttg aaagcgaaag 7260 ggaaaccaga ggagctctct cgacgcagga ctcggcttgc tgaagcgcgc acggcaagag 7320 gcgaggggcg gcgactggtg agtacgccaa aaattttgac tagcggaggc tagaaggaga 7380 gagatgggtg cgagagcgtc agtattaagc gggggagaat tagatcgcga tgggaaaaaa 7440 ttcggttaag gccaggggga aagaaaaaat ataaattaaa acatatagta tgggcaagca 7500 gggagctaga acgattcgca gttaatcctg gcctgttaga aacatcagaa ggctgtagac 7560 aaatactggg acagctacaa ccatcccttc agacaggatc agaagaactt agatcattat 7620 ataatacagt agcaaccctc tattgtgtgc atcaaaggat agagataaaa gacaccaagg 7680 aagctttaga caagatagag gaagagcaaa acaaaagtaa gaccaccgca cagcaagcgg 7740 ccgctgatct tcagacctgg aggaggagat atgagggaca attggagaag tgaattatat 7800 aaatataaag tagtaaaaat tgaaccatta ggagtagcac ccaccaaggc aaagagaaga 7860 gtggtgcaga gagaaaaaag agcagtggga ataggagctt tgttccttgg gttcttggga 7920 gcagcaggaa gcactatggg cgcagcgtca atgacgctga cggtacaggc cagacaatta 7980 ttgtctggta tagtgcagca gcagaacaat ttgctgaggg ctattgaggc gcaacagcat 8040 ctgttgcaac tcacagtctg gggcatcaag cagctccagg caagaatcct ggctgtggaa 8100 agatacctaa aggatcaaca gctcctgggg atttggggtt gctctggaaa actcatttgc 8160 accactgctg tgccttggaa tgctagttgg agtaataaat ctctggaaca gatttggaat 8220 cacacgacct ggatggagtg ggacagagaa attaacaatt acacaagctt aatacactcc 8280 ttaattgaag aatcgcaaaa ccagcaagaa aagaatgaac aagaattatt ggaattagat 8340 aaatgggcaa gtttgtggaa ttggtttaac ataacaaatt ggctgtggta tataaaatta 8400 ttcataatga tagtaggagg cttggtaggt ttaagaatag tttttgctgt actttctata 8460 gtgaatagag ttaggcaggg atattcacca ttatcgtttc agacccacct cccaaccccg 8520 aggggaccct tgcgcctttt ccaaggcagc cctgggtttg cgcagggacg cggctgctct 8580 gggcgtggtt ccgggaaacg cagcggcgcc gaccctgggt ctcgcacatt cttcacgtcc 8640 gttcgcagcg tcacccggat cttcgccgct acccttgtgg gccccccggc gacgcttcct 8700 gctccgcccc taagtcggga aggttccttg cggttcgcgg cgtgccggac gtgacaaacg 8760 gaagccgcac gtctcactag taccctcgca gacggacagc gccagggagc aatggcagcg 8820 cgccgaccgc gatgggctgt ggccaatagc ggctgctcag cagggcgcgc cgagagcagc 8880 ggccgggaag gggcggtgcg ggaggcgggg tgtggggcgg tagtgtgggc cctgttcctg 8940 cccgcgcggt gttccgcatt ctgcaagcct ccggagcgca cgtcggcagt cggctccctc 9000 gttgaccgaa tcaccgacct ctctccccag ggggtaccca gctgtctaga gaattctaga 9060 tcttgagaca aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt 9120 acagtgcagg ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac 9180 aaaaacaaat tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccac 9240 tttggcgccg gctcgagggg g 9261 <210> 41 <211> 204 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 41 Met Lys Thr Phe Asn Ile Ser Gln Gln Asp Leu Glu Leu Val Glu Val 1 5 10 15 Ala Thr Glu Lys Ile Thr Met Leu Tyr Glu Asp Asn Lys His His Val 20 25 30 Gly Ala Ala Ile Arg Thr Lys Thr Gly Glu Ile Ile Ser Ala Val His 35 40 45 Ile Glu Ala Tyr Ile Gly Arg Val Thr Val Cys Ala Glu Ala Ile Ala 50 55 60 Ile Gly Ser Ala Val Ser Asn Gly Gln Lys Asp Phe Asp Thr Ile Val 65 70 75 80 Ala Val Arg His Pro Tyr Ser Asp Glu Val Asp Arg Ser Ile Arg Val 85 90 95 Val Ser Pro Cys Gly Met Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr 100 105 110 Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile 115 120 125 Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln 130 135 140 Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr 145 150 155 160 Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe 165 170 175 Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg 180 185 190 Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn 195 200 <210> 42 <211> 8873 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 42 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgtagggagt tgatttcaga ctatgcacca 780 gattgttttg tgttaataga aatgaatggc aagttagtca aaactacgat tgaagaactc 840 attccactca aatatacccg aaattaatta ttaagaattc gacccagctt tcttgtacaa 900 agtggttggt aagcctatcc ctaaccctct cctcggtctc gattctacgt agtaatgagc 960 tagcagtctc gaggttaacg aattccgccc cccccctaac gttactggcc gaagccgctt 1020 ggaataaggc cggtgtgcgc ttgtctatat gttattttcc accatattgc cgtcttttgg 1080 caatgtgagg gcccggaaac ctggccctgt cttcttgacg agcattccta ggggtctttc 1140 ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg aaggaagcag ttcctctgga 1200 agcttcttga agacaaacaa cgtctgtagc gaccctttgc aggcagcgga accccccacc 1260 tggcgacagg tgcccctgcg gccaaaagcc acgtgtataa gatacacctg caaaggcggc 1320 acaaccccag tgccacgttg tgagttggat agttgtggaa agagtcaaat ggctctcctc 1380 aagcgtattc aacaaggggc tgaaggatgc ccagaaggta ccccattgta tgggatctga 1440 tctggggcct cggtgcacat gctttacatg tgtttagtcg aggttaaaaa aacgtctagg 1500 ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgataatacc atggtgagca 1560 agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag gtgcacatgg 1620 agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc cgcccctacg 1680 agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc ttcgcctggg 1740 acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac cccgccgaca 1800 tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc gtgatgaact 1860 tcgaggacgg cggcgtggtg accgtgaccc aggactcctc cctgcaggac ggcgagttca 1920 tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta atgcagaaga 1980 agaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc gccctgaagg 2040 gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct gaggtcaaga 2100 ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc aacatcaagt 2160 tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa cgcgccgagg 2220 gccgccactc caccggcggc atggacgagc tgtacaagta acaccggtgg cgcgttaagt 2280 cgacaatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt 2340 tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc 2400 ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga 2460 gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc 2520 cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct 2580 ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg 2640 gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct 2700 gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc 2760 cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg 2820 tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgcgtcgact 2880 ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg 2940 ggactggaag ggctaattca ctcccaacga agacaagatc tgctttttgc ttgtactggg 3000 tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg 3060 cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt 3120 gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt 3180 acgtatagta gttcatgtca tcttattatt cagtatttat aacttgcaaa gaaatgaata 3240 tcagagagtg agaggaactt gtttattgca gcttataatg gttacaaata aagcaatagc 3300 atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa 3360 ctcatcaatg tatcttatca tgtctggctc tagctatccc gcccctaact ccgcccatcc 3420 cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta atttttttta 3480 tttatgcaga ggccgaggcc gcctcggcct ctgagctatt ccagaagtag tgaggaggct 3540 tttttggagg cctagggacg tacccaattc gccctatagt gagtcgtatt acgcgcgctc 3600 actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc aacttaatcg 3660 ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc gcaccgatcg 3720 cccttcccaa cagttgcgca gcctgaatgg cgaatgggac gcgccctgta gcggcgcatt 3780 aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc 3840 gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca 3900 agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc 3960 caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt 4020 tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac 4080 aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc 4140 ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt 4200 aacgcttaca atttaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta 4260 tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt 4320 caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc 4380 ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa 4440 gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt 4500 aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt 4560 ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact cggtcgccgc 4620 atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg 4680 gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg 4740 gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac 4800 atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca 4860 aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg caaactatta 4920 actggcgaac tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat 4980 aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa 5040 tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag 5100 ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat 5160 agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt 5220 tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg 5280 aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga 5340 gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta 5400 atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa 5460 gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact 5520 gttcttctag tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca 5580 tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt 5640 accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg 5700 ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag 5760 cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta 5820 agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat 5880 ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg 5940 tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc 6000 ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac 6060 cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc 6120 gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt 6180 tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc gggcagtgag 6240 cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg 6300 cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac aggaaacagc 6360 tatgaccatg attacgccaa gcgcgcaatt aaccctcact aaagggaaca aaagctggag 6420 ctgcaagctt aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga 6480 gttagcaaca tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa 6540 ggtggtacga tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa 6600 ccactgaatt gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg 6660 ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac 6720 tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt 6780 gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca 6840 gtggcgcccg aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag 6900 gactcggctt gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc 6960 aaaaattttg actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa 7020 gcgggggaga attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa 7080 atataaatta aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc 7140 tggcctgtta gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct 7200 tcagacagga tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt 7260 gcatcaaagg atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca 7320 aaacaaaagt aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag 7380 atatgaggga caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat 7440 taggagtagc acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg 7500 gaataggagc tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt 7560 caatgacgct gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca 7620 atttgctgag ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca 7680 agcagctcca ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg 7740 ggatttgggg ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt 7800 ggagtaataa atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag 7860 aaattaacaa ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag 7920 aaaagaatga acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta 7980 acataacaaa ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag 8040 gtttaagaat agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac 8100 cattatcgtt tcagacccac ctcccaaccc cgaggggacc cttgcgcctt ttccaaggca 8160 gccctgggtt tgcgcaggga cgcggctgct ctgggcgtgg ttccgggaaa cgcagcggcg 8220 ccgaccctgg gtctcgcaca ttcttcacgt ccgttcgcag cgtcacccgg atcttcgccg 8280 ctacccttgt gggccccccg gcgacgcttc ctgctccgcc cctaagtcgg gaaggttcct 8340 tgcggttcgc ggcgtgccgg acgtgacaaa cggaagccgc acgtctcact agtaccctcg 8400 cagacggaca gcgccaggga gcaatggcag cgcgccgacc gcgatgggct gtggccaata 8460 gcggctgctc agcagggcgc gccgagagca gcggccggga aggggcggtg cgggaggcgg 8520 ggtgtggggc ggtagtgtgg gccctgttcc tgcccgcgcg gtgttccgca ttctgcaagc 8580 ctccggagcg cacgtcggca gtcggctccc tcgttgaccg aatcaccgac ctctctcccc 8640 agggggtacc cagctgtcta gagaattcta gatcttgaga caaatggcag tattcatcca 8700 caattttaaa agaaaagggg ggattggggg gtacagtgca ggggaaagaa tagtagacat 8760 aatagcaaca gacatacaaa ctaaagaatt acaaaaacaa attacaaaaa ttcaaaattt 8820 tcgggtttat tacagggaca gcagagatcc actttggcgc cggctcgagg ggg 8873 <210> 43 <211> 74 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 43 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Arg Glu Leu Ile Ser Asp Tyr Ala Pro Asp Cys 35 40 45 Phe Val Leu Ile Glu Met Asn Gly Lys Leu Val Lys Thr Thr Ile Glu 50 55 60 Glu Leu Ile Pro Leu Lys Tyr Thr Arg Asn 65 70 <210> 44 <211> 9309 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 44 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaccgagta caagcccacg 660 gtgcgcctcg ccacccgcga cgacgtcccc agggccgtac gcaccctcgc cgccgcgttc 720 gccgactacc ccgccacgcg ccacaccgtc gatccggacc gccacatcga gcgggtcacc 780 gagctgcaag aactcttcct cacgcgcgtc gggctcgaca tcggcaaggt gtgggtcgcg 840 gacgacggcg ccgcggtggc ggtctggacc acgccggaga gcgtcgaagc gggggcggtg 900 ttcgccgaga tcggcccgcg catggccgag ttgagcggtt cccggctggc cgcgcagcaa 960 cagatggaag gcctcctggc gccgcaccgg cccaagtgcc tttcatacga gaccgagatc 1020 ctgactgtcg agtacggatt gcttcctatc ggcaaaatcg tggagaagag gattgaatgt 1080 accgtctatt cagtcgataa taatgggaac atctacacac agcccgtggc tcaatggcac 1140 gacagaggag agcaggaagt ttttgaatac tgtctcgagg acggatccct catccgcgct 1200 actaaagatc ataagtttat gaccgtggac ggccagatgc tgccaattga cgaaattttt 1260 gaacgagagc tggatctgat gagagtcgac aaccttccaa actgattaat taagaattcg 1320 acccagcttt cttgtacaaa gtggttggta agcctatccc taaccctctc ctcggtctcg 1380 attctacgta gtaatgagct agcagtctcg aggttaacga attccgcccc ccccctaacg 1440 ttactggccg aagccgcttg gaataaggcc ggtgtgcgct tgtctatatg ttattttcca 1500 ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga 1560 gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga 1620 aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca 1680 ggcagcggaa ccccccacct ggcgacaggt gcccctgcgg ccaaaagcca cgtgtataag 1740 atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa 1800 gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac 1860 cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga 1920 ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac 1980 gataatacca tggccatgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 2040 gagggcaccg tggacaacca tcacttcaag tgcacatccg agggcgaagg caagccctac 2100 gagggcaccc agaccatgag aatcaaggtg gtcgagggcg gccctctccc cttcgccttc 2160 gacatcctgg ctactagctt cctctacggc agcaagacct tcatcaacca cacccagggc 2220 atccccgact tcttcaagca gtccttccct gagggcttca catgggagag agtcaccaca 2280 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 2340 atctacaacg tcaagatcag aggggtgaac ttcacatcca acggccctgt gatgcagaag 2400 aaaacactcg gctgggaggc cttcaccgag acgctgtacc ccgctgacgg cggcctggaa 2460 ggcagaaacg acatggccct gaagctcgtg ggcgggagcc atctgatcgc aaacatcaag 2520 accacatata gatccaagaa acccgctaag aacctcaaga tgcctggcgt ctactatgtg 2580 gactacagac tggaaagaat caaggaggcc aacaacgaga cctacgtcga gcagcacgag 2640 gtggcagtgg ccagatactg cgacctccct agcaaactgg ggcacaagct taattaacac 2700 cggtggcgcg ttaagtcgac aatcaacctc tggattacaa aatttgtgaa agattgactg 2760 gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt 2820 atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc 2880 tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt 2940 ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga 3000 ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct 3060 gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat 3120 cgtcctttcc ttggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct 3180 gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc 3240 tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg 3300 cctccccgcg tcgactttaa gaccaatgac ttacaaggca gctgtagatc ttagccactt 3360 tttaaaagaa aaggggggac tggaagggct aattcactcc caacgaagac aagatctgct 3420 ttttgcttgt actgggtctc tctggttaga ccagatctga gcctgggagc tctctggcta 3480 actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc aagtagtgtg 3540 tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt agtcagtgtg 3600 gaaaatctct agcagtacgt atagtagttc atgtcatctt attattcagt atttataact 3660 tgcaaagaaa tgaatatcag agagtgagag gaacttgttt attgcagctt ataatggtta 3720 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 3780 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggctctagc tatcccgccc 3840 ctaactccgc ccatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc 3900 tgactaattt tttttattta tgcagaggcc gaggccgcct cggcctctga gctattccag 3960 aagtagtgag gaggcttttt tggaggccta gggacgtacc caattcgccc tatagtgagt 4020 cgtattacgc gcgctcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg 4080 ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag 4140 aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgggacgcgc 4200 cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac 4260 ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg 4320 ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt 4380 tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc 4440 cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct 4500 tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga 4560 ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga 4620 attttaacaa aatattaacg cttacaattt aggtggcact tttcggggaa atgtgcgcgg 4680 aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata 4740 accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg 4800 tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac 4860 gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact 4920 ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat 4980 gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga 5040 gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac 5100 agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat 5160 gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac 5220 cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct 5280 gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac 5340 gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga 5400 ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg 5460 gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact 5520 ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac 5580 tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta 5640 actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt 5700 taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga 5760 gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc 5820 tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt 5880 ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc 5940 gcagatacca aatactgttc ttctagtgta gccgtagtta ggccaccact tcaagaactc 6000 tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg 6060 cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg 6120 gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga 6180 actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc 6240 ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg 6300 gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg 6360 atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt 6420 tttacggttc ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc 6480 tgattctgtg gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg 6540 aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc 6600 gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt ttcccgactg 6660 gaaagcgggc agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca 6720 ggctttacac tttatgcttc cggctcgtat gttgtgtgga attgtgagcg gataacaatt 6780 tcacacagga aacagctatg accatgatta cgccaagcgc gcaattaacc ctcactaaag 6840 ggaacaaaag ctggagctgc aagcttaatg tagtcttatg caatactctt gtagtcttgc 6900 aacatggtaa cgatgagtta gcaacatgcc ttacaaggag agaaaaagca ccgtgcatgc 6960 cgattggtgg aagtaaggtg gtacgatcgt gccttattag gaaggcaaca gacgggtctg 7020 acatggattg gacgaaccac tgaattgccg cattgcagag atattgtatt taagtgccta 7080 gctcgataca taaacgggtc tctctggtta gaccagatct gagcctggga gctctctggc 7140 taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg 7200 tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg 7260 tggaaaatct ctagcagtgg cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg 7320 agctctctcg acgcaggact cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc 7380 gactggtgag tacgccaaaa attttgacta gcggaggcta gaaggagaga gatgggtgcg 7440 agagcgtcag tattaagcgg gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc 7500 cagggggaaa gaaaaaatat aaattaaaac atatagtatg ggcaagcagg gagctagaac 7560 gattcgcagt taatcctggc ctgttagaaa catcagaagg ctgtagacaa atactgggac 7620 agctacaacc atcccttcag acaggatcag aagaacttag atcattatat aatacagtag 7680 caaccctcta ttgtgtgcat caaaggatag agataaaaga caccaaggaa gctttagaca 7740 agatagagga agagcaaaac aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc 7800 agacctggag gaggagatat gagggacaat tggagaagtg aattatataa atataaagta 7860 gtaaaaattg aaccattagg agtagcaccc accaaggcaa agagaagagt ggtgcagaga 7920 gaaaaaagag cagtgggaat aggagctttg ttccttgggt tcttgggagc agcaggaagc 7980 actatgggcg cagcgtcaat gacgctgacg gtacaggcca gacaattatt gtctggtata 8040 gtgcagcagc agaacaattt gctgagggct attgaggcgc aacagcatct gttgcaactc 8100 acagtctggg gcatcaagca gctccaggca agaatcctgg ctgtggaaag atacctaaag 8160 gatcaacagc tcctggggat ttggggttgc tctggaaaac tcatttgcac cactgctgtg 8220 ccttggaatg ctagttggag taataaatct ctggaacaga tttggaatca cacgacctgg 8280 atggagtggg acagagaaat taacaattac acaagcttaa tacactcctt aattgaagaa 8340 tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg aattagataa atgggcaagt 8400 ttgtggaatt ggtttaacat aacaaattgg ctgtggtata taaaattatt cataatgata 8460 gtaggaggct tggtaggttt aagaatagtt tttgctgtac tttctatagt gaatagagtt 8520 aggcagggat attcaccatt atcgtttcag acccacctcc caaccccgag gggacccttg 8580 cgccttttcc aaggcagccc tgggtttgcg cagggacgcg gctgctctgg gcgtggttcc 8640 gggaaacgca gcggcgccga ccctgggtct cgcacattct tcacgtccgt tcgcagcgtc 8700 acccggatct tcgccgctac ccttgtgggc cccccggcga cgcttcctgc tccgccccta 8760 agtcgggaag gttccttgcg gttcgcggcg tgccggacgt gacaaacgga agccgcacgt 8820 ctcactagta ccctcgcaga cggacagcgc cagggagcaa tggcagcgcg ccgaccgcga 8880 tgggctgtgg ccaatagcgg ctgctcagca gggcgcgccg agagcagcgg ccgggaaggg 8940 gcggtgcggg aggcggggtg tggggcggta gtgtgggccc tgttcctgcc cgcgcggtgt 9000 tccgcattct gcaagcctcc ggagcgcacg tcggcagtcg gctccctcgt tgaccgaatc 9060 accgacctct ctccccaggg ggtacccagc tgtctagaga attctagatc ttgagacaaa 9120 tggcagtatt catccacaat tttaaaagaa aaggggggat tggggggtac agtgcagggg 9180 aaagaatagt agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta 9240 caaaaattca aaattttcgg gtttattaca gggacagcag agatccactt tggcgccggc 9300 tcgaggggg 9309 <210> 45 <211> 221 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 45 Met Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp Asp Val 1 5 10 15 Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr Pro Ala 20 25 30 Thr Arg His Thr Val Asp Pro Asp Arg His Ile Glu Arg Val Thr Glu 35 40 45 Leu Gln Glu Leu Phe Leu Thr Arg Val Gly Leu Asp Ile Gly Lys Val 50 55 60 Trp Val Ala Asp Asp Gly Ala Ala Val Ala Val Trp Thr Thr Pro Glu 65 70 75 80 Ser Val Glu Ala Gly Ala Val Phe Ala Glu Ile Gly Pro Arg Met Ala 85 90 95 Glu Leu Ser Gly Ser Arg Leu Ala Ala Gln Gln Gln Met Glu Gly Leu 100 105 110 Leu Ala Pro His Arg Pro Lys Cys Leu Ser Tyr Glu Thr Glu Ile Leu 115 120 125 Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg 130 135 140 Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr 145 150 155 160 Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu 165 170 175 Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys 180 185 190 Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu 195 200 205 Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn 210 215 220 <210> 46 <211> 9003 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 46 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcgagcccg cgtggttcct ggccaccgtc 780 ggcgtctcgc ccgaccacca gggcaagggt ctgggcagcg ccgtcgtgct ccccggagtg 840 gaggcggccg agcgcgccgg ggtgcccgcc ttcctggaga cctccgcgcc ccgcaacctc 900 cccttctacg agcggctcgg cttcaccgtc accgccgacg tcgaggtgcc cgaaggaccg 960 cgcacctggt gcatgacccg caagcccggt gcctgattaa ttaagaattc gacccagctt 1020 tcttgtacaa agtggttggt aagcctatcc ctaaccctct cctcggtctc gattctacgt 1080 agtaatgagc tagcagtctc gaggttaacg aattccgccc cccccctaac gttactggcc 1140 gaagccgctt ggaataaggc cggtgtgcgc ttgtctatat gttattttcc accatattgc 1200 cgtcttttgg caatgtgagg gcccggaaac ctggccctgt cttcttgacg agcattccta 1260 ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg aaggaagcag 1320 ttcctctgga agcttcttga agacaaacaa cgtctgtagc gaccctttgc aggcagcgga 1380 accccccacc tggcgacagg tgcccctgcg gccaaaagcc acgtgtataa gatacacctg 1440 caaaggcggc acaaccccag tgccacgttg tgagttggat agttgtggaa agagtcaaat 1500 ggctctcctc aagcgtattc aacaaggggc tgaaggatgc ccagaaggta ccccattgta 1560 tgggatctga tctggggcct cggtgcacat gctttacatg tgtttagtcg aggttaaaaa 1620 aacgtctagg ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgataatacc 1680 atggtgagca agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag 1740 gtgcacatgg agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc 1800 cgcccctacg agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc 1860 ttcgcctggg acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac 1920 cccgccgaca tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc 1980 gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc aggactcctc cctgcaggac 2040 ggcgagttca tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta 2100 atgcagaaga agaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc 2160 gccctgaagg gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct 2220 gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc 2280 aacatcaagt tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa 2340 cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaagta acaccggtgg 2400 cgcgttaagt cgacaatcaa cctctggatt acaaaatttg tgaaagattg actggtattc 2460 ttaactatgt tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg 2520 ctattgcttc ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc 2580 tttatgagga gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg 2640 acgcaacccc cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg 2700 ctttccccct ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga 2760 caggggctcg gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct 2820 ttccttggct gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg 2880 tcccttcggc cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc 2940 ctcttccgcg tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc 3000 cgcgtcgact ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa 3060 agaaaagggg ggactggaag ggctaattca ctcccaacga agacaagatc tgctttttgc 3120 ttgtactggg tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg 3180 gaacccactg cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg 3240 tctgttgtgt gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat 3300 ctctagcagt acgtatagta gttcatgtca tcttattatt cagtatttat aacttgcaaa 3360 gaaatgaata tcagagagtg agaggaactt gtttattgca gcttataatg gttacaaata 3420 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 3480 tttgtccaaa ctcatcaatg tatcttatca tgtctggctc tagctatccc gcccctaact 3540 ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta 3600 atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt ccagaagtag 3660 tgaggaggct tttttggagg cctagggacg tacccaattc gccctatagt gagtcgtatt 3720 acgcgcgctc actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc 3780 aacttaatcg ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc 3840 gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatgggac gcgccctgta 3900 gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca 3960 gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct 4020 ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc 4080 acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat 4140 agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc 4200 aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc 4260 cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta 4320 acaaaatatt aacgcttaca atttaggtgg cacttttcgg ggaaatgtgc gcggaacccc 4380 tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg 4440 ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc 4500 ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt 4560 gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct 4620 caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac 4680 ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact 4740 cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa 4800 gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga 4860 taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt 4920 tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga 4980 agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg 5040 caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat 5100 ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat 5160 tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc 5220 agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga 5280 tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc 5340 agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag 5400 gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc 5460 gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt 5520 tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt 5580 gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat 5640 accaaatact gttcttctag tgtagccgta gttaggccac cacttcaaga actctgtagc 5700 accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa 5760 gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg 5820 ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag 5880 atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag 5940 gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa 6000 cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt 6060 gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg 6120 gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc 6180 tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac 6240 cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct 6300 ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc 6360 gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt 6420 acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac 6480 aggaaacagc tatgaccatg attacgccaa gcgcgcaatt aaccctcact aaagggaaca 6540 aaagctggag ctgcaagctt aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg 6600 gtaacgatga gttagcaaca tgccttacaa ggagagaaaa agcaccgtgc atgccgattg 6660 gtggaagtaa ggtggtacga tcgtgcctta ttaggaaggc aacagacggg tctgacatgg 6720 attggacgaa ccactgaatt gccgcattgc agagatattg tatttaagtg cctagctcga 6780 tacataaacg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta 6840 gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc 6900 cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa 6960 atctctagca gtggcgcccg aacagggact tgaaagcgaa agggaaacca gaggagctct 7020 ctcgacgcag gactcggctt gctgaagcgc gcacggcaag aggcgagggg cggcgactgg 7080 tgagtacgcc aaaaattttg actagcggag gctagaagga gagagatggg tgcgagagcg 7140 tcagtattaa gcgggggaga attagatcgc gatgggaaaa aattcggtta aggccagggg 7200 gaaagaaaaa atataaatta aaacatatag tatgggcaag cagggagcta gaacgattcg 7260 cagttaatcc tggcctgtta gaaacatcag aaggctgtag acaaatactg ggacagctac 7320 aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca gtagcaaccc 7380 tctattgtgt gcatcaaagg atagagataa aagacaccaa ggaagcttta gacaagatag 7440 aggaagagca aaacaaaagt aagaccaccg cacagcaagc ggccgctgat cttcagacct 7500 ggaggaggag atatgaggga caattggaga agtgaattat ataaatataa agtagtaaaa 7560 attgaaccat taggagtagc acccaccaag gcaaagagaa gagtggtgca gagagaaaaa 7620 agagcagtgg gaataggagc tttgttcctt gggttcttgg gagcagcagg aagcactatg 7680 ggcgcagcgt caatgacgct gacggtacag gccagacaat tattgtctgg tatagtgcag 7740 cagcagaaca atttgctgag ggctattgag gcgcaacagc atctgttgca actcacagtc 7800 tggggcatca agcagctcca ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa 7860 cagctcctgg ggatttgggg ttgctctgga aaactcattt gcaccactgc tgtgccttgg 7920 aatgctagtt ggagtaataa atctctggaa cagatttgga atcacacgac ctggatggag 7980 tgggacagag aaattaacaa ttacacaagc ttaatacact ccttaattga agaatcgcaa 8040 aaccagcaag aaaagaatga acaagaatta ttggaattag ataaatgggc aagtttgtgg 8100 aattggttta acataacaaa ttggctgtgg tatataaaat tattcataat gatagtagga 8160 ggcttggtag gtttaagaat agtttttgct gtactttcta tagtgaatag agttaggcag 8220 ggatattcac cattatcgtt tcagacccac ctcccaaccc cgaggggacc cttgcgcctt 8280 ttccaaggca gccctgggtt tgcgcaggga cgcggctgct ctgggcgtgg ttccgggaaa 8340 cgcagcggcg ccgaccctgg gtctcgcaca ttcttcacgt ccgttcgcag cgtcacccgg 8400 atcttcgccg ctacccttgt gggccccccg gcgacgcttc ctgctccgcc cctaagtcgg 8460 gaaggttcct tgcggttcgc ggcgtgccgg acgtgacaaa cggaagccgc acgtctcact 8520 agtaccctcg cagacggaca gcgccaggga gcaatggcag cgcgccgacc gcgatgggct 8580 gtggccaata gcggctgctc agcagggcgc gccgagagca gcggccggga aggggcggtg 8640 cgggaggcgg ggtgtggggc ggtagtgtgg gccctgttcc tgcccgcgcg gtgttccgca 8700 ttctgcaagc ctccggagcg cacgtcggca gtcggctccc tcgttgaccg aatcaccgac 8760 ctctctcccc agggggtacc cagctgtcta gagaattcta gatcttgaga caaatggcag 8820 tattcatcca caattttaaa agaaaagggg ggattggggg gtacagtgca ggggaaagaa 8880 tagtagacat aatagcaaca gacatacaaa ctaaagaatt acaaaaacaa attacaaaaa 8940 ttcaaaattt tcgggtttat tacagggaca gcagagatcc actttggcgc cggctcgagg 9000 ggg 9003 <210> 47 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 47 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Glu Pro Ala Trp Phe Leu Ala Thr Val Gly Val 35 40 45 Ser Pro Asp His Gln Gly Lys Gly Leu Gly Ser Ala Val Val Leu Pro 50 55 60 Gly Val Glu Ala Ala Glu Arg Ala Gly Val Pro Ala Phe Leu Glu Thr 65 70 75 80 Ser Ala Pro Arg Asn Leu Pro Phe Tyr Glu Arg Leu Gly Phe Thr Val 85 90 95 Thr Ala Asp Val Glu Val Pro Glu Gly Pro Arg Thr Trp Cys Met Thr 100 105 110 Arg Lys Pro Gly Ala 115 <210> 48 <211> 9264 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 48 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaccgagta caagcccacg 660 gtgcgcctcg ccacccgcga cgacgtcccc agggccgtac gcaccctcgc cgccgcgttc 720 gccgactacc ccgccacgcg ccacaccgtc gatccggacc gccacatcga gcgggtcacc 780 gagctgcaag aactcttcct cacgcgcgtc gggctcgaca tcggcaaggt gtgggtcgcg 840 gacgacggcg ccgcggtggc ggtctggacc acgccggaga gcgtcgaagc gggggcggtg 900 ttcgccgaga tcggcccgcg catggccgag ttgagcggtt gtatcagtgg cgactccctg 960 atctcactcg caagcactgg aaagcgagtt agcatcaagg acttgctgga cgaaaaggat 1020 ttcgaaattt gggcaatcaa tgagcagacc atgaaactgg agtctgcaaa ggtgtcccgg 1080 gtgttttgca cgggtaagaa gcttgtttat atccttaaaa ctagactggg ccggacgatc 1140 aaagccaccg cgaaccacag attcttgaca atcgacgggt ggaaacggct ggacgaactg 1200 agcttgaagg agcacatcgc ccttcctcgg aagctcgagt catcttccct gcagctgtga 1260 ttaattaaga attcgaccca gctttcttgt acaaagtggt tggtaagcct atccctaacc 1320 ctctcctcgg tctcgattct acgtagtaat gagctagcag tctcgaggtt aacgaattcc 1380 gccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt gcgcttgtct 1440 atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc 1500 ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc 1560 tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg 1620 tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcccc tgcggccaaa 1680 agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt 1740 ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg 1800 atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta 1860 catgtgttta gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt 1920 tcctttgaaa aacacgataa taccatggcc atgagcgagc tgattaagga gaacatgcac 1980 atgaagctgt acatggaggg caccgtggac aaccatcact tcaagtgcac atccgagggc 2040 gaaggcaagc cctacgaggg cacccagacc atgagaatca aggtggtcga gggcggccct 2100 ctccccttcg ccttcgacat cctggctact agcttcctct acggcagcaa gaccttcatc 2160 aaccacaccc agggcatccc cgacttcttc aagcagtcct tccctgaggg cttcacatgg 2220 gagagagtca ccacatacga agacgggggc gtgctgaccg ctacccagga caccagcctc 2280 caggacggct gcctcatcta caacgtcaag atcagagggg tgaacttcac atccaacggc 2340 cctgtgatgc agaagaaaac actcggctgg gaggccttca ccgagacgct gtaccccgct 2400 gacggcggcc tggaaggcag aaacgacatg gccctgaagc tcgtgggcgg gagccatctg 2460 atcgcaaaca tcaagaccac atatagatcc aagaaacccg ctaagaacct caagatgcct 2520 ggcgtctact atgtggacta cagactggaa agaatcaagg aggccaacaa cgagacctac 2580 gtcgagcagc acgaggtggc agtggccaga tactgcgacc tccctagcaa actggggcac 2640 aagcttaatt aacaccggtg gcgcgttaag tcgacaatca acctctggat tacaaaattt 2700 gtgaaagatt gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg 2760 ctttaatgcc tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt 2820 ataaatcctg gttgctgtct ctttatgagg agttgtggcc cgttgtcagg caacgtggcg 2880 tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg gggcattgcc accacctgtc 2940 agctcctttc cgggactttc gctttccccc tccctattgc cacggcggaa ctcatcgccg 3000 cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt 3060 tgtcggggaa atcatcgtcc tttccttggc tgctcgcctg tgttgccacc tggattctgc 3120 gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg 3180 gcctgctgcc ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga 3240 tctccctttg ggccgcctcc ccgcgtcgac tttaagacca atgacttaca aggcagctgt 3300 agatcttagc cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaacg 3360 aagacaagat ctgctttttg cttgtactgg gtctctctgg ttagaccaga tctgagcctg 3420 ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt 3480 gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc 3540 cttttagtca gtgtggaaaa tctctagcag tacgtatagt agttcatgtc atcttattat 3600 tcagtattta taacttgcaa agaaatgaat atcagagagt gagaggaact tgtttattgc 3660 agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt 3720 ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggct 3780 ctagctatcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat 3840 tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc 3900 tctgagctat tccagaagta gtgaggaggc ttttttggag gcctagggac gtacccaatt 3960 cgccctatag tgagtcgtat tacgcgcgct cactggccgt cgttttacaa cgtcgtgact 4020 gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct 4080 ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg 4140 gcgaatggga cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca 4200 gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct 4260 ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt 4320 tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac 4380 gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct 4440 ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt 4500 ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac 4560 aaaaatttaa cgcgaatttt aacaaaatat taacgcttac aatttaggtg gcacttttcg 4620 gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc 4680 gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag 4740 tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt 4800 tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt 4860 gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga 4920 acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat 4980 tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga 5040 gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag 5100 tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg 5160 accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg 5220 ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt 5280 agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg 5340 gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc 5400 ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg 5460 tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac 5520 ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact 5580 gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa 5640 acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa 5700 aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg 5760 atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc 5820 gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac 5880 tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt agttaggcca 5940 ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt 6000 ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc 6060 ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg 6120 aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc 6180 cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac 6240 gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct 6300 ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc 6360 cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt 6420 tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac 6480 cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg 6540 cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca gctggcacga 6600 caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga gttagctcac 6660 tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt 6720 gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca agcgcgcaat 6780 taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc ttatgcaata 6840 ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca aggagagaaa 6900 aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt attaggaagg 6960 caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg cagagatatt 7020 gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca gatctgagcc 7080 tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga 7140 gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaga 7200 cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac ttgaaagcga 7260 aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg cgcacggcaa 7320 gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga ggctagaagg 7380 agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg cgatgggaaa 7440 aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata gtatgggcaa 7500 gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca gaaggctgta 7560 gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa cttagatcat 7620 tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata aaagacacca 7680 aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc gcacagcaag 7740 cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag aagtgaatta 7800 tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa ggcaaagaga 7860 agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct tgggttcttg 7920 ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca ggccagacaa 7980 ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga ggcgcaacag 8040 catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat cctggctgtg 8100 gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg aaaactcatt 8160 tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga acagatttgg 8220 aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag cttaatacac 8280 tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt attggaatta 8340 gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg gtatataaaa 8400 ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc tgtactttct 8460 atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca cctcccaacc 8520 ccgaggggac ccttgcgcct tttccaaggc agccctgggt ttgcgcaggg acgcggctgc 8580 tctgggcgtg gttccgggaa acgcagcggc gccgaccctg ggtctcgcac attcttcacg 8640 tccgttcgca gcgtcacccg gatcttcgcc gctacccttg tgggcccccc ggcgacgctt 8700 cctgctccgc ccctaagtcg ggaaggttcc ttgcggttcg cggcgtgccg gacgtgacaa 8760 acggaagccg cacgtctcac tagtaccctc gcagacggac agcgccaggg agcaatggca 8820 gcgcgccgac cgcgatgggc tgtggccaat agcggctgct cagcagggcg cgccgagagc 8880 agcggccggg aaggggcggt gcgggaggcg gggtgtgggg cggtagtgtg ggccctgttc 8940 ctgcccgcgc ggtgttccgc attctgcaag cctccggagc gcacgtcggc agtcggctcc 9000 ctcgttgacc gaatcaccga cctctctccc cagggggtac ccagctgtct agagaattct 9060 agatcttgag acaaatggca gtattcatcc acaattttaa aagaaaaggg gggattgggg 9120 ggtacagtgc aggggaaaga atagtagaca taatagcaac agacatacaa actaaagaat 9180 tacaaaaaca aattacaaaa attcaaaatt ttcgggttta ttacagggac agcagagatc 9240 cactttggcg ccggctcgag gggg 9264 <210> 49 <211> 206 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 49 Met Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp Asp Val 1 5 10 15 Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr Pro Ala 20 25 30 Thr Arg His Thr Val Asp Pro Asp Arg His Ile Glu Arg Val Thr Glu 35 40 45 Leu Gln Glu Leu Phe Leu Thr Arg Val Gly Leu Asp Ile Gly Lys Val 50 55 60 Trp Val Ala Asp Asp Gly Ala Ala Val Ala Val Trp Thr Thr Pro Glu 65 70 75 80 Ser Val Glu Ala Gly Ala Val Phe Ala Glu Ile Gly Pro Arg Met Ala 85 90 95 Glu Leu Ser Gly Cys Ile Ser Gly Asp Ser Leu Ile Ser Leu Ala Ser 100 105 110 Thr Gly Lys Arg Val Ser Ile Lys Asp Leu Leu Asp Glu Lys Asp Phe 115 120 125 Glu Ile Trp Ala Ile Asn Glu Gln Thr Met Lys Leu Glu Ser Ala Lys 130 135 140 Val Ser Arg Val Phe Cys Thr Gly Lys Lys Leu Val Tyr Ile Leu Lys 145 150 155 160 Thr Arg Leu Gly Arg Thr Ile Lys Ala Thr Ala Asn His Arg Phe Leu 165 170 175 Thr Ile Asp Gly Trp Lys Arg Leu Asp Glu Leu Ser Leu Lys Glu His 180 185 190 Ile Ala Leu Pro Arg Lys Leu Glu Ser Ser Ser Leu Gln Leu 195 200 205 <210> 50 <211> 9096 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 50 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgagtcc cgaaatcgaa 660 aagctctctc agagcgatat atattgggac tccatcgtaa gcataacaga gacgggggtc 720 gaggaggtgt tcgatctgac agttcctggg cctcataatt tcgtagcgaa cgacatcatt 780 gtacataact cccggctggc cgcgcagcaa cagatggaag gcctcctggc gccgcaccgg 840 cccaaggagc ccgcgtggtt cctggccacc gtcggcgtct cgcccgacca ccagggcaag 900 ggtctgggca gcgccgtcgt gctccccgga gtggaggcgg ccgagcgcgc cggggtgccc 960 gccttcctgg agacctccgc gccccgcaac ctccccttct acgagcggct cggcttcacc 1020 gtcaccgccg acgtcgaggt gcccgaagga ccgcgcacct ggtgcatgac ccgcaagccc 1080 ggtgcctgat taattaagaa ttcgacccag ctttcttgta caaagtggtt ggtaagccta 1140 tccctaaccc tctcctcggt ctcgattcta cgtagtaatg agctagcagt ctcgaggtta 1200 acgaattccg ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg 1260 cgcttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga 1320 aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa 1380 tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa 1440 caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcccct 1500 gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg 1560 ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg 1620 ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtgca 1680 catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg 1740 acgtggtttt cctttgaaaa acacgataat accatggtga gcaagggcga ggaggataac 1800 atggccatca tcaaggagtt catgcgcttc aaggtgcaca tggagggctc cgtgaacggc 1860 cacgagttcg agatcgaggg cgagggcgag ggccgcccct acgagggcac ccagaccgcc 1920 aagctgaagg tgaccaaggg tggccccctg cccttcgcct gggacatcct gtcccctcag 1980 ttcatgtacg gctccaaggc ctacgtgaag caccccgccg acatccccga ctacttgaag 2040 ctgtccttcc ccgagggctt caagtgggag cgcgtgatga acttcgagga cggcggcgtg 2100 gtgaccgtga cccaggactc ctccctgcag gacggcgagt tcatctacaa ggtgaagctg 2160 cgcggcacca acttcccctc cgacggcccc gtaatgcaga agaagaccat gggctgggag 2220 gcctcctccg agcggatgta ccccgaggac ggcgccctga agggcgagat caagcagagg 2280 ctgaagctga aggacggcgg ccactacgac gctgaggtca agaccaccta caaggccaag 2340 aagcccgtgc agctgcccgg cgcctacaac gtcaacatca agttggacat cacctcccac 2400 aacgaggact acaccatcgt ggaacagtac gaacgcgccg agggccgcca ctccaccggc 2460 ggcatggacg agctgtacaa gtaacaccgg tggcgcgtta agtcgacaat caacctctgg 2520 attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct tttacgctat 2580 gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg gctttcattt 2640 tctcctcctt gtataaatcc tggttgctgt ctctttatga ggagttgtgg cccgttgtca 2700 ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt tggggcattg 2760 ccaccacctg tcagctcctt tccgggactt tcgctttccc cctccctatt gccacggcgg 2820 aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg ggcactgaca 2880 attccgtggt gttgtcgggg aaatcatcgt cctttccttg gctgctcgcc tgtgttgcca 2940 cctggattct gcgcgggacg tccttctgct acgtcccttc ggccctcaat ccagcggacc 3000 ttccttcccg cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc cttcgccctc 3060 agacgagtcg gatctccctt tgggccgcct ccccgcgtcg actttaagac caatgactta 3120 caaggcagct gtagatctta gccacttttt aaaagaaaag gggggactgg aagggctaat 3180 tcactcccaa cgaagacaag atctgctttt tgcttgtact gggtctctct ggttagacca 3240 gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag 3300 cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag 3360 atccctcaga cccttttagt cagtgtggaa aatctctagc agtacgtata gtagttcatg 3420 tcatcttatt attcagtatt tataacttgc aaagaaatga atatcagaga gtgagaggaa 3480 cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa 3540 taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta 3600 tcatgtctgg ctctagctat cccgccccta actccgccca tcccgcccct aactccgccc 3660 agttccgccc attctccgcc ccatggctga ctaatttttt ttatttatgc agaggccgag 3720 gccgcctcgg cctctgagct attccagaag tagtgaggag gcttttttgg aggcctaggg 3780 acgtacccaa ttcgccctat agtgagtcgt attacgcgcg ctcactggcc gtcgttttac 3840 aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca gcacatcccc 3900 ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc 3960 gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg 4020 tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt 4080 tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc 4140 tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg 4200 gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg 4260 agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct 4320 cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg 4380 agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttagg 4440 tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc 4500 aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag 4560 gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg 4620 ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt 4680 gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt 4740 tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt 4800 attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa 4860 tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag 4920 agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac 4980 aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac 5040 tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac 5100 cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac 5160 tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact 5220 tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg 5280 tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt 5340 tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat 5400 aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta 5460 gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa 5520 tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga 5580 aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac 5640 aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt 5700 tccgaaggta actggcttca gcagagcgca gataccaaat actgttcttc tagtgtagcc 5760 gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat 5820 cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag 5880 acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc 5940 cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag 6000 cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac 6060 aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg 6120 gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct 6180 atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc 6240 tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga 6300 gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga 6360 agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg 6420 cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt 6480 gagttagctc actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt 6540 gtgtggaatt gtgagcggat aacaatttca cacaggaaac agctatgacc atgattacgc 6600 caagcgcgca attaaccctc actaaaggga acaaaagctg gagctgcaag cttaatgtag 6660 tcttatgcaa tactcttgta gtcttgcaac atggtaacga tgagttagca acatgcctta 6720 caaggagaga aaaagcaccg tgcatgccga ttggtggaag taaggtggta cgatcgtgcc 6780 ttattaggaa ggcaacagac gggtctgaca tggattggac gaaccactga attgccgcat 6840 tgcagagata ttgtatttaa gtgcctagct cgatacataa acgggtctct ctggttagac 6900 cagatctgag cctgggagct ctctggctaa ctagggaacc cactgcttaa gcctcaataa 6960 agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag 7020 agatccctca gaccctttta gtcagtgtgg aaaatctcta gcagtggcgc ccgaacaggg 7080 acttgaaagc gaaagggaaa ccagaggagc tctctcgacg caggactcgg cttgctgaag 7140 cgcgcacggc aagaggcgag gggcggcgac tggtgagtac gccaaaaatt ttgactagcg 7200 gaggctagaa ggagagagat gggtgcgaga gcgtcagtat taagcggggg agaattagat 7260 cgcgatggga aaaaattcgg ttaaggccag ggggaaagaa aaaatataaa ttaaaacata 7320 tagtatgggc aagcagggag ctagaacgat tcgcagttaa tcctggcctg ttagaaacat 7380 cagaaggctg tagacaaata ctgggacagc tacaaccatc ccttcagaca ggatcagaag 7440 aacttagatc attatataat acagtagcaa ccctctattg tgtgcatcaa aggatagaga 7500 taaaagacac caaggaagct ttagacaaga tagaggaaga gcaaaacaaa agtaagacca 7560 ccgcacagca agcggccgct gatcttcaga cctggaggag gagatatgag ggacaattgg 7620 agaagtgaat tatataaata taaagtagta aaaattgaac cattaggagt agcacccacc 7680 aaggcaaaga gaagagtggt gcagagagaa aaaagagcag tgggaatagg agctttgttc 7740 cttgggttct tgggagcagc aggaagcact atgggcgcag cgtcaatgac gctgacggta 7800 caggccagac aattattgtc tggtatagtg cagcagcaga acaatttgct gagggctatt 7860 gaggcgcaac agcatctgtt gcaactcaca gtctggggca tcaagcagct ccaggcaaga 7920 atcctggctg tggaaagata cctaaaggat caacagctcc tggggatttg gggttgctct 7980 ggaaaactca tttgcaccac tgctgtgcct tggaatgcta gttggagtaa taaatctctg 8040 gaacagattt ggaatcacac gacctggatg gagtgggaca gagaaattaa caattacaca 8100 agcttaatac actccttaat tgaagaatcg caaaaccagc aagaaaagaa tgaacaagaa 8160 ttattggaat tagataaatg ggcaagtttg tggaattggt ttaacataac aaattggctg 8220 tggtatataa aattattcat aatgatagta ggaggcttgg taggtttaag aatagttttt 8280 gctgtacttt ctatagtgaa tagagttagg cagggatatt caccattatc gtttcagacc 8340 cacctcccaa ccccgagggg acccttgcgc cttttccaag gcagccctgg gtttgcgcag 8400 ggacgcggct gctctgggcg tggttccggg aaacgcagcg gcgccgaccc tgggtctcgc 8460 acattcttca cgtccgttcg cagcgtcacc cggatcttcg ccgctaccct tgtgggcccc 8520 ccggcgacgc ttcctgctcc gcccctaagt cgggaaggtt ccttgcggtt cgcggcgtgc 8580 cggacgtgac aaacggaagc cgcacgtctc actagtaccc tcgcagacgg acagcgccag 8640 ggagcaatgg cagcgcgccg accgcgatgg gctgtggcca atagcggctg ctcagcaggg 8700 cgcgccgaga gcagcggccg ggaaggggcg gtgcgggagg cggggtgtgg ggcggtagtg 8760 tgggccctgt tcctgcccgc gcggtgttcc gcattctgca agcctccgga gcgcacgtcg 8820 gcagtcggct ccctcgttga ccgaatcacc gacctctctc cccagggggt acccagctgt 8880 ctagagaatt ctagatcttg agacaaatgg cagtattcat ccacaatttt aaaagaaaag 8940 gggggattgg ggggtacagt gcaggggaaa gaatagtaga cataatagca acagacatac 9000 aaactaaaga attacaaaaa caaattacaa aaattcaaaa ttttcgggtt tattacaggg 9060 acagcagaga tccactttgg cgccggctcg aggggg 9096 <210> 51 <211> 148 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 51 Met Ser Pro Glu Ile Glu Lys Leu Ser Gln Ser Asp Ile Tyr Trp Asp 1 5 10 15 Ser Ile Val Ser Ile Thr Glu Thr Gly Val Glu Glu Val Phe Asp Leu 20 25 30 Thr Val Pro Gly Pro His Asn Phe Val Ala Asn Asp Ile Ile Val His 35 40 45 Asn Ser Arg Leu Ala Ala Gln Gln Gln Met Glu Gly Leu Leu Ala Pro 50 55 60 His Arg Pro Lys Glu Pro Ala Trp Phe Leu Ala Thr Val Gly Val Ser 65 70 75 80 Pro Asp His Gln Gly Lys Gly Leu Gly Ser Ala Val Val Leu Pro Gly 85 90 95 Val Glu Ala Ala Glu Arg Ala Gly Val Pro Ala Phe Leu Glu Thr Ser 100 105 110 Ala Pro Arg Asn Leu Pro Phe Tyr Glu Arg Leu Gly Phe Thr Val Thr 115 120 125 Ala Asp Val Glu Val Pro Glu Gly Pro Arg Thr Trp Cys Met Thr Arg 130 135 140 Lys Pro Gly Ala 145 <210> 52 <211> 9351 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 52 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgggatcggc cattgaacaa 660 gatggattgc acgcaggttc tccggccgct tgggtggaga ggctattcgg ctatgactgg 720 gcacaacaga caatcggctg ctctgatgcc gccgtgttcc ggctgtcagc gcaggggcgc 780 ccggttcttt ttgtcaagac cgacctgtcc ggtgccctga atgaactgca ggacgaggca 840 gcgcggctat cgtggctggc cacgacgggc gttccttgcg cagctgtgct cgacgttgtc 900 actgaagcgg gaagggactg gctgctattg ggcgaagtgc cggggcagga tctcctgtca 960 tctcaccttg ctcctgccga gaaagtatcc atcatggctg atgcaatgcg gcggctgcat 1020 acgcttgatc cggctacctg cctttcatac gagaccgaga tcctgactgt cgagtacgga 1080 ttgcttccta tcggcaaaat cgtggagaag aggattgaat gtaccgtcta ttcagtcgat 1140 aataatggga acatctacac acagcccgtg gctcaatggc acgacagagg agagcaggaa 1200 gtttttgaat actgtctcga ggacggatcc ctcatccgcg ctactaaaga tcataagttt 1260 atgaccgtgg acggccagat gctgccaatt gacgaaattt ttgaacgaga gctggatctg 1320 atgagagtcg acaaccttcc aaactgatta attaagaatt cgacccagct ttcttgtaca 1380 aagtggttgg taagcctatc cctaaccctc tcctcggtct cgattctacg tagtaatgag 1440 ctagcagtct cgaggttaac gaattccgcc ccccccctaa cgttactggc cgaagccgct 1500 tggaataagg ccggtgtgcg cttgtctata tgttattttc caccatattg ccgtcttttg 1560 gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct aggggtcttt 1620 cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg 1680 aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg aaccccccac 1740 ctggcgacag gtgcccctgc ggccaaaagc cacgtgtata agatacacct gcaaaggcgg 1800 cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa tggctctcct 1860 caagcgtatt caacaagggg ctgaaggatg cccagaaggt accccattgt atgggatctg 1920 atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa aaacgtctag 1980 gccccccgaa ccacggggac gtggttttcc tttgaaaaac acgataatac catggccatg 2040 agcgagctga ttaaggagaa catgcacatg aagctgtaca tggagggcac cgtggacaac 2100 catcacttca agtgcacatc cgagggcgaa ggcaagccct acgagggcac ccagaccatg 2160 agaatcaagg tggtcgaggg cggccctctc cccttcgcct tcgacatcct ggctactagc 2220 ttcctctacg gcagcaagac cttcatcaac cacacccagg gcatccccga cttcttcaag 2280 cagtccttcc ctgagggctt cacatgggag agagtcacca catacgaaga cgggggcgtg 2340 ctgaccgcta cccaggacac cagcctccag gacggctgcc tcatctacaa cgtcaagatc 2400 agaggggtga acttcacatc caacggccct gtgatgcaga agaaaacact cggctgggag 2460 gccttcaccg agacgctgta ccccgctgac ggcggcctgg aaggcagaaa cgacatggcc 2520 ctgaagctcg tgggcgggag ccatctgatc gcaaacatca agaccacata tagatccaag 2580 aaacccgcta agaacctcaa gatgcctggc gtctactatg tggactacag actggaaaga 2640 atcaaggagg ccaacaacga gacctacgtc gagcagcacg aggtggcagt ggccagatac 2700 tgcgacctcc ctagcaaact ggggcacaag cttaattaac accggtggcg cgttaagtcg 2760 acaatcaacc tctggattac aaaatttgtg aaagattgac tggtattctt aactatgttg 2820 ctccttttac gctatgtgga tacgctgctt taatgccttt gtatcatgct attgcttccc 2880 gtatggcttt cattttctcc tccttgtata aatcctggtt gctgtctctt tatgaggagt 2940 tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac gcaaccccca 3000 ctggttgggg cattgccacc acctgtcagc tcctttccgg gactttcgct ttccccctcc 3060 ctattgccac ggcggaactc atcgccgcct gccttgcccg ctgctggaca ggggctcggc 3120 tgttgggcac tgacaattcc gtggtgttgt cggggaaatc atcgtccttt ccttggctgc 3180 tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc ccttcggccc 3240 tcaatccagc ggaccttcct tcccgcggcc tgctgccggc tctgcggcct cttccgcgtc 3300 ttcgccttcg ccctcagacg agtcggatct ccctttgggc cgcctccccg cgtcgacttt 3360 aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag aaaagggggg 3420 actggaaggg ctaattcact cccaacgaag acaagatctg ctttttgctt gtactgggtc 3480 tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct 3540 taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga 3600 ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtac 3660 gtatagtagt tcatgtcatc ttattattca gtatttataa cttgcaaaga aatgaatatc 3720 agagagtgag aggaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat 3780 cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact 3840 catcaatgta tcttatcatg tctggctcta gctatcccgc ccctaactcc gcccatcccg 3900 cccctaactc cgcccagttc cgcccattct ccgccccatg gctgactaat tttttttatt 3960 tatgcagagg ccgaggccgc ctcggcctct gagctattcc agaagtagtg aggaggcttt 4020 tttggaggcc tagggacgta cccaattcgc cctatagtga gtcgtattac gcgcgctcac 4080 tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg cgttacccaa cttaatcgcc 4140 ttgcagcaca tccccctttc gccagctggc gtaatagcga agaggcccgc accgatcgcc 4200 cttcccaaca gttgcgcagc ctgaatggcg aatgggacgc gccctgtagc ggcgcattaa 4260 gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc gccctagcgc 4320 ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag 4380 ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac ctcgacccca 4440 aaaaacttga ttagggtgat ggttcacgta gtgggccatc gccctgatag acggtttttc 4500 gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa actggaacaa 4560 cactcaaccc tatctcggtc tattcttttg atttataagg gattttgccg atttcggcct 4620 attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattttaac aaaatattaa 4680 cgcttacaat ttaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt 4740 tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca 4800 ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt 4860 ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga 4920 tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa 4980 gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct 5040 gctatgtggc gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat 5100 acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga 5160 tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc 5220 caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat 5280 gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa 5340 cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac 5400 tggcgaacta cttactctag cttcccggca acaattaata gactggatgg aggcggataa 5460 agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc 5520 tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc 5580 ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag 5640 acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag accaagttta 5700 ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa 5760 gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc 5820 gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat 5880 ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga 5940 gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt 6000 tcttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata 6060 cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac 6120 cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg 6180 ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg 6240 tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag 6300 cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct 6360 ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc 6420 aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt 6480 ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg 6540 tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga 6600 gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg 6660 gccgattcat taatgcagct ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg 6720 caacgcaatt aatgtgagtt agctcactca ttaggcaccc caggctttac actttatgct 6780 tccggctcgt atgttgtgtg gaattgtgag cggataacaa tttcacacag gaaacagcta 6840 tgaccatgat tacgccaagc gcgcaattaa ccctcactaa agggaacaaa agctggagct 6900 gcaagcttaa tgtagtctta tgcaatactc ttgtagtctt gcaacatggt aacgatgagt 6960 tagcaacatg ccttacaagg agagaaaaag caccgtgcat gccgattggt ggaagtaagg 7020 tggtacgatc gtgccttatt aggaaggcaa cagacgggtc tgacatggat tggacgaacc 7080 actgaattgc cgcattgcag agatattgta tttaagtgcc tagctcgata cataaacggg 7140 tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg 7200 cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt 7260 gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt 7320 ggcgcccgaa cagggacttg aaagcgaaag ggaaaccaga ggagctctct cgacgcagga 7380 ctcggcttgc tgaagcgcgc acggcaagag gcgaggggcg gcgactggtg agtacgccaa 7440 aaattttgac tagcggaggc tagaaggaga gagatgggtg cgagagcgtc agtattaagc 7500 gggggagaat tagatcgcga tgggaaaaaa ttcggttaag gccaggggga aagaaaaaat 7560 ataaattaaa acatatagta tgggcaagca gggagctaga acgattcgca gttaatcctg 7620 gcctgttaga aacatcagaa ggctgtagac aaatactggg acagctacaa ccatcccttc 7680 agacaggatc agaagaactt agatcattat ataatacagt agcaaccctc tattgtgtgc 7740 atcaaaggat agagataaaa gacaccaagg aagctttaga caagatagag gaagagcaaa 7800 acaaaagtaa gaccaccgca cagcaagcgg ccgctgatct tcagacctgg aggaggagat 7860 atgagggaca attggagaag tgaattatat aaatataaag tagtaaaaat tgaaccatta 7920 ggagtagcac ccaccaaggc aaagagaaga gtggtgcaga gagaaaaaag agcagtggga 7980 ataggagctt tgttccttgg gttcttggga gcagcaggaa gcactatggg cgcagcgtca 8040 atgacgctga cggtacaggc cagacaatta ttgtctggta tagtgcagca gcagaacaat 8100 ttgctgaggg ctattgaggc gcaacagcat ctgttgcaac tcacagtctg gggcatcaag 8160 cagctccagg caagaatcct ggctgtggaa agatacctaa aggatcaaca gctcctgggg 8220 atttggggtt gctctggaaa actcatttgc accactgctg tgccttggaa tgctagttgg 8280 agtaataaat ctctggaaca gatttggaat cacacgacct ggatggagtg ggacagagaa 8340 attaacaatt acacaagctt aatacactcc ttaattgaag aatcgcaaaa ccagcaagaa 8400 aagaatgaac aagaattatt ggaattagat aaatgggcaa gtttgtggaa ttggtttaac 8460 ataacaaatt ggctgtggta tataaaatta ttcataatga tagtaggagg cttggtaggt 8520 ttaagaatag tttttgctgt actttctata gtgaatagag ttaggcaggg atattcacca 8580 ttatcgtttc agacccacct cccaaccccg aggggaccct tgcgcctttt ccaaggcagc 8640 cctgggtttg cgcagggacg cggctgctct gggcgtggtt ccgggaaacg cagcggcgcc 8700 gaccctgggt ctcgcacatt cttcacgtcc gttcgcagcg tcacccggat cttcgccgct 8760 acccttgtgg gccccccggc gacgcttcct gctccgcccc taagtcggga aggttccttg 8820 cggttcgcgg cgtgccggac gtgacaaacg gaagccgcac gtctcactag taccctcgca 8880 gacggacagc gccagggagc aatggcagcg cgccgaccgc gatgggctgt ggccaatagc 8940 ggctgctcag cagggcgcgc cgagagcagc ggccgggaag gggcggtgcg ggaggcgggg 9000 tgtggggcgg tagtgtgggc cctgttcctg cccgcgcggt gttccgcatt ctgcaagcct 9060 ccggagcgca cgtcggcagt cggctccctc gttgaccgaa tcaccgacct ctctccccag 9120 ggggtaccca gctgtctaga gaattctaga tcttgagaca aatggcagta ttcatccaca 9180 attttaaaag aaaagggggg attggggggt acagtgcagg ggaaagaata gtagacataa 9240 tagcaacaga catacaaact aaagaattac aaaaacaaat tacaaaaatt caaaattttc 9300 gggtttatta cagggacagc agagatccac tttggcgccg gctcgagggg g 9351 <210> 53 <211> 235 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 53 Met Gly Ser Ala Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala 1 5 10 15 Ala Trp Val Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile 20 25 30 Gly Cys Ser Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro 35 40 45 Val Leu Phe Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln 50 55 60 Asp Glu Ala Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys 65 70 75 80 Ala Ala Val Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu 85 90 95 Leu Gly Glu Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro 100 105 110 Ala Glu Lys Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr 115 120 125 Leu Asp Pro Ala Thr Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val 130 135 140 Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu 145 150 155 160 Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro 165 170 175 Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys 180 185 190 Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met 195 200 205 Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu 210 215 220 Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn 225 230 235 <210> 54 <211> 9162 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 54 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcccattcg accaccaagc gaaacatcgc 780 atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa 840 gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg catgcccgac 900 ggcgatgatc tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat 960 ggccgctttt ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac 1020 atagcgttgg ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc 1080 ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt 1140 gacgagttct tctgattaat taagaattcg acccagcttt cttgtacaaa gtggttggta 1200 agcctatccc taaccctctc ctcggtctcg attctacgta gtaatgagct agcagtctcg 1260 aggttaacga attccgcccc ccccctaacg ttactggccg aagccgcttg gaataaggcc 1320 ggtgtgcgct tgtctatatg ttattttcca ccatattgcc gtcttttggc aatgtgaggg 1380 cccggaaacc tggccctgtc ttcttgacga gcattcctag gggtctttcc cctctcgcca 1440 aaggaatgca aggtctgttg aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa 1500 gacaaacaac gtctgtagcg accctttgca ggcagcggaa ccccccacct ggcgacaggt 1560 gcccctgcgg ccaaaagcca cgtgtataag atacacctgc aaaggcggca caaccccagt 1620 gccacgttgt gagttggata gttgtggaaa gagtcaaatg gctctcctca agcgtattca 1680 acaaggggct gaaggatgcc cagaaggtac cccattgtat gggatctgat ctggggcctc 1740 ggtgcacatg ctttacatgt gtttagtcga ggttaaaaaa acgtctaggc cccccgaacc 1800 acggggacgt ggttttcctt tgaaaaacac gataatacca tggtgagcaa gggcgaggag 1860 gataacatgg ccatcatcaa ggagttcatg cgcttcaagg tgcacatgga gggctccgtg 1920 aacggccacg agttcgagat cgagggcgag ggcgagggcc gcccctacga gggcacccag 1980 accgccaagc tgaaggtgac caagggtggc cccctgccct tcgcctggga catcctgtcc 2040 cctcagttca tgtacggctc caaggcctac gtgaagcacc ccgccgacat ccccgactac 2100 ttgaagctgt ccttccccga gggcttcaag tgggagcgcg tgatgaactt cgaggacggc 2160 ggcgtggtga ccgtgaccca ggactcctcc ctgcaggacg gcgagttcat ctacaaggtg 2220 aagctgcgcg gcaccaactt cccctccgac ggccccgtaa tgcagaagaa gaccatgggc 2280 tgggaggcct cctccgagcg gatgtacccc gaggacggcg ccctgaaggg cgagatcaag 2340 cagaggctga agctgaagga cggcggccac tacgacgctg aggtcaagac cacctacaag 2400 gccaagaagc ccgtgcagct gcccggcgcc tacaacgtca acatcaagtt ggacatcacc 2460 tcccacaacg aggactacac catcgtggaa cagtacgaac gcgccgaggg ccgccactcc 2520 accggcggca tggacgagct gtacaagtaa caccggtggc gcgttaagtc gacaatcaac 2580 ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta 2640 cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt 2700 tcattttctc ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg 2760 ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg 2820 gcattgccac cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca 2880 cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca 2940 ctgacaattc cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg 3000 ttgccacctg gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag 3060 cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc 3120 gccctcagac gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat 3180 gacttacaag gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg 3240 gctaattcac tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt 3300 agaccagatc tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca 3360 ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa 3420 ctagagatcc ctcagaccct tttagtcagt gtggaaaatc tctagcagta cgtatagtag 3480 ttcatgtcat cttattattc agtatttata acttgcaaag aaatgaatat cagagagtga 3540 gaggaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 3600 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 3660 atcttatcat gtctggctct agctatcccg cccctaactc cgcccatccc gcccctaact 3720 ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag 3780 gccgaggccg cctcggcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc 3840 ctagggacgt acccaattcg ccctatagtg agtcgtatta cgcgcgctca ctggccgtcg 3900 ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc cttgcagcac 3960 atcccccttt cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac 4020 agttgcgcag cctgaatggc gaatgggacg cgccctgtag cggcgcatta agcgcggcgg 4080 gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt 4140 tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc 4200 gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg 4260 attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga 4320 cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc 4380 ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa 4440 aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta acgcttacaa 4500 tttaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat 4560 acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg 4620 aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc 4680 attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga 4740 tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga 4800 gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg 4860 cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc 4920 tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac 4980 agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact 5040 tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca 5100 tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg 5160 tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact 5220 acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg 5280 accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg 5340 tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat 5400 cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc 5460 tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat 5520 actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt 5580 tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc 5640 cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt 5700 gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac 5760 tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt 5820 gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct 5880 gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga 5940 ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac 6000 acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg 6060 agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt 6120 cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc 6180 tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg 6240 gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc 6300 ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc 6360 ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag 6420 cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca 6480 ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc gcaacgcaat 6540 taatgtgagt tagctcactc attaggcacc ccaggcttta cactttatgc ttccggctcg 6600 tatgttgtgt ggaattgtga gcggataaca atttcacaca ggaaacagct atgaccatga 6660 ttacgccaag cgcgcaatta accctcacta aagggaacaa aagctggagc tgcaagctta 6720 atgtagtctt atgcaatact cttgtagtct tgcaacatgg taacgatgag ttagcaacat 6780 gccttacaag gagagaaaaa gcaccgtgca tgccgattgg tggaagtaag gtggtacgat 6840 cgtgccttat taggaaggca acagacgggt ctgacatgga ttggacgaac cactgaattg 6900 ccgcattgca gagatattgt atttaagtgc ctagctcgat acataaacgg gtctctctgg 6960 ttagaccaga tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct 7020 caataaagct tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt 7080 aactagagat ccctcagacc cttttagtca gtgtggaaaa tctctagcag tggcgcccga 7140 acagggactt gaaagcgaaa gggaaaccag aggagctctc tcgacgcagg actcggcttg 7200 ctgaagcgcg cacggcaaga ggcgaggggc ggcgactggt gagtacgcca aaaattttga 7260 ctagcggagg ctagaaggag agagatgggt gcgagagcgt cagtattaag cgggggagaa 7320 ttagatcgcg atgggaaaaa attcggttaa ggccaggggg aaagaaaaaa tataaattaa 7380 aacatatagt atgggcaagc agggagctag aacgattcgc agttaatcct ggcctgttag 7440 aaacatcaga aggctgtaga caaatactgg gacagctaca accatccctt cagacaggat 7500 cagaagaact tagatcatta tataatacag tagcaaccct ctattgtgtg catcaaagga 7560 tagagataaa agacaccaag gaagctttag acaagataga ggaagagcaa aacaaaagta 7620 agaccaccgc acagcaagcg gccgctgatc ttcagacctg gaggaggaga tatgagggac 7680 aattggagaa gtgaattata taaatataaa gtagtaaaaa ttgaaccatt aggagtagca 7740 cccaccaagg caaagagaag agtggtgcag agagaaaaaa gagcagtggg aataggagct 7800 ttgttccttg ggttcttggg agcagcagga agcactatgg gcgcagcgtc aatgacgctg 7860 acggtacagg ccagacaatt attgtctggt atagtgcagc agcagaacaa tttgctgagg 7920 gctattgagg cgcaacagca tctgttgcaa ctcacagtct ggggcatcaa gcagctccag 7980 gcaagaatcc tggctgtgga aagataccta aaggatcaac agctcctggg gatttggggt 8040 tgctctggaa aactcatttg caccactgct gtgccttgga atgctagttg gagtaataaa 8100 tctctggaac agatttggaa tcacacgacc tggatggagt gggacagaga aattaacaat 8160 tacacaagct taatacactc cttaattgaa gaatcgcaaa accagcaaga aaagaatgaa 8220 caagaattat tggaattaga taaatgggca agtttgtgga attggtttaa cataacaaat 8280 tggctgtggt atataaaatt attcataatg atagtaggag gcttggtagg tttaagaata 8340 gtttttgctg tactttctat agtgaataga gttaggcagg gatattcacc attatcgttt 8400 cagacccacc tcccaacccc gaggggaccc ttgcgccttt tccaaggcag ccctgggttt 8460 gcgcagggac gcggctgctc tgggcgtggt tccgggaaac gcagcggcgc cgaccctggg 8520 tctcgcacat tcttcacgtc cgttcgcagc gtcacccgga tcttcgccgc tacccttgtg 8580 ggccccccgg cgacgcttcc tgctccgccc ctaagtcggg aaggttcctt gcggttcgcg 8640 gcgtgccgga cgtgacaaac ggaagccgca cgtctcacta gtaccctcgc agacggacag 8700 cgccagggag caatggcagc gcgccgaccg cgatgggctg tggccaatag cggctgctca 8760 gcagggcgcg ccgagagcag cggccgggaa ggggcggtgc gggaggcggg gtgtggggcg 8820 gtagtgtggg ccctgttcct gcccgcgcgg tgttccgcat tctgcaagcc tccggagcgc 8880 acgtcggcag tcggctccct cgttgaccga atcaccgacc tctctcccca gggggtaccc 8940 agctgtctag agaattctag atcttgagac aaatggcagt attcatccac aattttaaaa 9000 gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata atagcaacag 9060 acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt cgggtttatt 9120 acagggacag cagagatcca ctttggcgcc ggctcgaggg gg 9162 <210> 55 <211> 170 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 55 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Pro Phe Asp His Gln Ala Lys His Arg Ile Glu 35 40 45 Arg Ala Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp Leu 50 55 60 Asp Glu Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg Leu 65 70 75 80 Lys Ala Arg Met Pro Asp Gly Asp Asp Leu Val Val Thr His Gly Asp 85 90 95 Ala Cys Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe Ser Gly Phe 100 105 110 Ile Asp Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln Asp Ile Ala 115 120 125 Leu Ala Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu Trp Ala Asp 130 135 140 Arg Phe Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser Gln Arg Ile 145 150 155 160 Ala Phe Tyr Arg Leu Leu Asp Glu Phe Phe 165 170 <210> 56 <211> 9534 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 56 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgggatcggc cattgaacaa 660 gatggattgc acgcaggttc tccggccgct tgggtggaga ggctattcgg ctatgactgg 720 gcacaacaga caatcggctg ctctgatgcc gccgtgttcc ggctgtcagc gcaggggcgc 780 ccggttcttt ttgtcaagac cgacctgtcc ggtgccctga atgaactgca ggacgaggca 840 gcgcggctat cgtggctggc cacgacgggc gttccttgcg cagctgtgct cgacgttgtc 900 actgaagcgg gaagggactg gctgctattg ggcgaagtgc cggggcagga tctcctgtca 960 tctcaccttg ctcctgccga gaaagtatcc atcatggctg atgcaatgcg gcggctgcat 1020 acgcttgatc cggctacctg cccattcgac caccaagcga aacatcgcat cgagcgagca 1080 cgtactcgga tggaagccgg tcttgtcgat caggatgatc tggacgaaga gcatcagggg 1140 ctcgcgccag ccgaactgtt cgccaggctc aaggcgcgca tgcccgacgg cgatgatctc 1200 gtcgtgaccc atggcgatgc ctgcctttca tacgagaccg agatcctgac tgtcgagtac 1260 ggattgcttc ctatcggcaa aatcgtggag aagaggattg aatgtaccgt ctattcagtc 1320 gataataatg ggaacatcta cacacagccc gtggctcaat ggcacgacag aggagagcag 1380 gaagtttttg aatactgtct cgaggacgga tccctcatcc gcgctactaa agatcataag 1440 tttatgaccg tggacggcca gatgctgcca attgacgaaa tttttgaacg agagctggat 1500 ctgatgagag tcgacaacct tccaaactga ttaattaaga attcgaccca gctttcttgt 1560 acaaagtggt tggtaagcct atccctaacc ctctcctcgg tctcgattct acgtagtaat 1620 gagctagcag tctcgaggtt aacgaattcc gccccccccc taacgttact ggccgaagcc 1680 gcttggaata aggccggtgt gcgcttgtct atatgttatt ttccaccata ttgccgtctt 1740 ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt gacgagcatt cctaggggtc 1800 tttcccctct cgccaaagga atgcaaggtc tgttgaatgt cgtgaaggaa gcagttcctc 1860 tggaagcttc ttgaagacaa acaacgtctg tagcgaccct ttgcaggcag cggaaccccc 1920 cacctggcga caggtgcccc tgcggccaaa agccacgtgt ataagataca cctgcaaagg 1980 cggcacaacc ccagtgccac gttgtgagtt ggatagttgt ggaaagagtc aaatggctct 2040 cctcaagcgt attcaacaag gggctgaagg atgcccagaa ggtaccccat tgtatgggat 2100 ctgatctggg gcctcggtgc acatgcttta catgtgttta gtcgaggtta aaaaaacgtc 2160 taggcccccc gaaccacggg gacgtggttt tcctttgaaa aacacgataa taccatggcc 2220 atgagcgagc tgattaagga gaacatgcac atgaagctgt acatggaggg caccgtggac 2280 aaccatcact tcaagtgcac atccgagggc gaaggcaagc cctacgaggg cacccagacc 2340 atgagaatca aggtggtcga gggcggccct ctccccttcg ccttcgacat cctggctact 2400 agcttcctct acggcagcaa gaccttcatc aaccacaccc agggcatccc cgacttcttc 2460 aagcagtcct tccctgaggg cttcacatgg gagagagtca ccacatacga agacgggggc 2520 gtgctgaccg ctacccagga caccagcctc caggacggct gcctcatcta caacgtcaag 2580 atcagagggg tgaacttcac atccaacggc cctgtgatgc agaagaaaac actcggctgg 2640 gaggccttca ccgagacgct gtaccccgct gacggcggcc tggaaggcag aaacgacatg 2700 gccctgaagc tcgtgggcgg gagccatctg atcgcaaaca tcaagaccac atatagatcc 2760 aagaaacccg ctaagaacct caagatgcct ggcgtctact atgtggacta cagactggaa 2820 agaatcaagg aggccaacaa cgagacctac gtcgagcagc acgaggtggc agtggccaga 2880 tactgcgacc tccctagcaa actggggcac aagcttaatt aacaccggtg gcgcgttaag 2940 tcgacaatca acctctggat tacaaaattt gtgaaagatt gactggtatt cttaactatg 3000 ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat gctattgctt 3060 cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct ctttatgagg 3120 agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc 3180 ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc gctttccccc 3240 tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc 3300 ggctgttggg cactgacaat tccgtggtgt tgtcggggaa atcatcgtcc tttccttggc 3360 tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac gtcccttcgg 3420 ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc 3480 gtcttcgcct tcgccctcag acgagtcgga tctccctttg ggccgcctcc ccgcgtcgac 3540 tttaagacca atgacttaca aggcagctgt agatcttagc cactttttaa aagaaaaggg 3600 gggactggaa gggctaattc actcccaacg aagacaagat ctgctttttg cttgtactgg 3660 gtctctctgg ttagaccaga tctgagcctg ggagctctct ggctaactag ggaacccact 3720 gcttaagcct caataaagct tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg 3780 tgactctggt aactagagat ccctcagacc cttttagtca gtgtggaaaa tctctagcag 3840 tacgtatagt agttcatgtc atcttattat tcagtattta taacttgcaa agaaatgaat 3900 atcagagagt gagaggaact tgtttattgc agcttataat ggttacaaat aaagcaatag 3960 catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa 4020 actcatcaat gtatcttatc atgtctggct ctagctatcc cgcccctaac tccgcccatc 4080 ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt 4140 atttatgcag aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc 4200 ttttttggag gcctagggac gtacccaatt cgccctatag tgagtcgtat tacgcgcgct 4260 cactggccgt cgttttacaa cgtcgtgact gggaaaaccc tggcgttacc caacttaatc 4320 gccttgcagc acatccccct ttcgccagct ggcgtaatag cgaagaggcc cgcaccgatc 4380 gcccttccca acagttgcgc agcctgaatg gcgaatggga cgcgccctgt agcggcgcat 4440 taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag 4500 cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc 4560 aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc 4620 ccaaaaaact tgattagggt gatggttcac gtagtgggcc atcgccctga tagacggttt 4680 ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa 4740 caacactcaa ccctatctcg gtctattctt ttgatttata agggattttg ccgatttcgg 4800 cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat 4860 taacgcttac aatttaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt 4920 atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct 4980 tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc 5040 cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa 5100 agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg 5160 taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt 5220 tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg 5280 catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac 5340 ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc 5400 ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa 5460 catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc 5520 aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt 5580 aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga 5640 taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa 5700 atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa 5760 gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa 5820 tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt 5880 ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt 5940 gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg 6000 agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt 6060 aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca 6120 agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac 6180 tgttcttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac 6240 atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct 6300 taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg 6360 gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca 6420 gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt 6480 aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta 6540 tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc 6600 gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc 6660 cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa 6720 ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag 6780 cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg 6840 ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag cgggcagtga 6900 gcgcaacgca attaatgtga gttagctcac tcattaggca ccccaggctt tacactttat 6960 gcttccggct cgtatgttgt gtggaattgt gagcggataa caatttcaca caggaaacag 7020 ctatgaccat gattacgcca agcgcgcaat taaccctcac taaagggaac aaaagctgga 7080 gctgcaagct taatgtagtc ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg 7140 agttagcaac atgccttaca aggagagaaa aagcaccgtg catgccgatt ggtggaagta 7200 aggtggtacg atcgtgcctt attaggaagg caacagacgg gtctgacatg gattggacga 7260 accactgaat tgccgcattg cagagatatt gtatttaagt gcctagctcg atacataaac 7320 gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca 7380 ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg 7440 tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc 7500 agtggcgccc gaacagggac ttgaaagcga aagggaaacc agaggagctc tctcgacgca 7560 ggactcggct tgctgaagcg cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc 7620 caaaaatttt gactagcgga ggctagaagg agagagatgg gtgcgagagc gtcagtatta 7680 agcgggggag aattagatcg cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa 7740 aatataaatt aaaacatata gtatgggcaa gcagggagct agaacgattc gcagttaatc 7800 ctggcctgtt agaaacatca gaaggctgta gacaaatact gggacagcta caaccatccc 7860 ttcagacagg atcagaagaa cttagatcat tatataatac agtagcaacc ctctattgtg 7920 tgcatcaaag gatagagata aaagacacca aggaagcttt agacaagata gaggaagagc 7980 aaaacaaaag taagaccacc gcacagcaag cggccgctga tcttcagacc tggaggagga 8040 gatatgaggg acaattggag aagtgaatta tataaatata aagtagtaaa aattgaacca 8100 ttaggagtag cacccaccaa ggcaaagaga agagtggtgc agagagaaaa aagagcagtg 8160 ggaataggag ctttgttcct tgggttcttg ggagcagcag gaagcactat gggcgcagcg 8220 tcaatgacgc tgacggtaca ggccagacaa ttattgtctg gtatagtgca gcagcagaac 8280 aatttgctga gggctattga ggcgcaacag catctgttgc aactcacagt ctggggcatc 8340 aagcagctcc aggcaagaat cctggctgtg gaaagatacc taaaggatca acagctcctg 8400 gggatttggg gttgctctgg aaaactcatt tgcaccactg ctgtgccttg gaatgctagt 8460 tggagtaata aatctctgga acagatttgg aatcacacga cctggatgga gtgggacaga 8520 gaaattaaca attacacaag cttaatacac tccttaattg aagaatcgca aaaccagcaa 8580 gaaaagaatg aacaagaatt attggaatta gataaatggg caagtttgtg gaattggttt 8640 aacataacaa attggctgtg gtatataaaa ttattcataa tgatagtagg aggcttggta 8700 ggtttaagaa tagtttttgc tgtactttct atagtgaata gagttaggca gggatattca 8760 ccattatcgt ttcagaccca cctcccaacc ccgaggggac ccttgcgcct tttccaaggc 8820 agccctgggt ttgcgcaggg acgcggctgc tctgggcgtg gttccgggaa acgcagcggc 8880 gccgaccctg ggtctcgcac attcttcacg tccgttcgca gcgtcacccg gatcttcgcc 8940 gctacccttg tgggcccccc ggcgacgctt cctgctccgc ccctaagtcg ggaaggttcc 9000 ttgcggttcg cggcgtgccg gacgtgacaa acggaagccg cacgtctcac tagtaccctc 9060 gcagacggac agcgccaggg agcaatggca gcgcgccgac cgcgatgggc tgtggccaat 9120 agcggctgct cagcagggcg cgccgagagc agcggccggg aaggggcggt gcgggaggcg 9180 gggtgtgggg cggtagtgtg ggccctgttc ctgcccgcgc ggtgttccgc attctgcaag 9240 cctccggagc gcacgtcggc agtcggctcc ctcgttgacc gaatcaccga cctctctccc 9300 cagggggtac ccagctgtct agagaattct agatcttgag acaaatggca gtattcatcc 9360 acaattttaa aagaaaaggg gggattgggg ggtacagtgc aggggaaaga atagtagaca 9420 taatagcaac agacatacaa actaaagaat tacaaaaaca aattacaaaa attcaaaatt 9480 ttcgggttta ttacagggac agcagagatc cactttggcg ccggctcgag gggg 9534 <210> 57 <211> 296 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 57 Met Gly Ser Ala Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala 1 5 10 15 Ala Trp Val Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile 20 25 30 Gly Cys Ser Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro 35 40 45 Val Leu Phe Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln 50 55 60 Asp Glu Ala Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys 65 70 75 80 Ala Ala Val Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu 85 90 95 Leu Gly Glu Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro 100 105 110 Ala Glu Lys Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr 115 120 125 Leu Asp Pro Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile 130 135 140 Glu Arg Ala Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp 145 150 155 160 Leu Asp Glu Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg 165 170 175 Leu Lys Ala Arg Met Pro Asp Gly Asp Asp Leu Val Val Thr His Gly 180 185 190 Asp Ala Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly 195 200 205 Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val 210 215 220 Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln 225 230 235 240 Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp 245 250 255 Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp 260 265 270 Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu 275 280 285 Met Arg Val Asp Asn Leu Pro Asn 290 295 <210> 58 <211> 8979 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 58 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcttgccga atatcatggt ggaaaatggc 780 cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg cggaccgcta tcaggacata 840 gcgttggcta cccgtgatat tgctgaagag cttggcggcg aatgggctga ccgcttcctc 900 gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg ccttctatcg ccttcttgac 960 gagttcttct gattaattaa gaattcgacc cagctttctt gtacaaagtg gttggtaagc 1020 ctatccctaa ccctctcctc ggtctcgatt ctacgtagta atgagctagc agtctcgagg 1080 ttaacgaatt ccgccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt 1140 gtgcgcttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc 1200 ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag 1260 gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac 1320 aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc 1380 cctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc 1440 acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca 1500 aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt 1560 gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg 1620 gggacgtggt tttcctttga aaaacacgat aataccatgg tgagcaaggg cgaggaggat 1680 aacatggcca tcatcaagga gttcatgcgc ttcaaggtgc acatggaggg ctccgtgaac 1740 ggccacgagt tcgagatcga gggcgagggc gagggccgcc cctacgaggg cacccagacc 1800 gccaagctga aggtgaccaa gggtggcccc ctgcccttcg cctgggacat cctgtcccct 1860 cagttcatgt acggctccaa ggcctacgtg aagcaccccg ccgacatccc cgactacttg 1920 aagctgtcct tccccgaggg cttcaagtgg gagcgcgtga tgaacttcga ggacggcggc 1980 gtggtgaccg tgacccagga ctcctccctg caggacggcg agttcatcta caaggtgaag 2040 ctgcgcggca ccaacttccc ctccgacggc cccgtaatgc agaagaagac catgggctgg 2100 gaggcctcct ccgagcggat gtaccccgag gacggcgccc tgaagggcga gatcaagcag 2160 aggctgaagc tgaaggacgg cggccactac gacgctgagg tcaagaccac ctacaaggcc 2220 aagaagcccg tgcagctgcc cggcgcctac aacgtcaaca tcaagttgga catcacctcc 2280 cacaacgagg actacaccat cgtggaacag tacgaacgcg ccgagggccg ccactccacc 2340 ggcggcatgg acgagctgta caagtaacac cggtggcgcg ttaagtcgac aatcaacctc 2400 tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct ccttttacgc 2460 tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt atggctttca 2520 ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg tggcccgttg 2580 tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact ggttggggca 2640 ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct attgccacgg 2700 cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg ttgggcactg 2760 acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc gcctgtgttg 2820 ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc aatccagcgg 2880 accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc 2940 ctcagacgag tcggatctcc ctttgggccg cctccccgcg tcgactttaa gaccaatgac 3000 ttacaaggca gctgtagatc ttagccactt tttaaaagaa aaggggggac tggaagggct 3060 aattcactcc caacgaagac aagatctgct ttttgcttgt actgggtctc tctggttaga 3120 ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata 3180 aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta 3240 gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagtacgt atagtagttc 3300 atgtcatctt attattcagt atttataact tgcaaagaaa tgaatatcag agagtgagag 3360 gaacttgttt attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac 3420 aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc 3480 ttatcatgtc tggctctagc tatcccgccc ctaactccgc ccatcccgcc cctaactccg 3540 cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc 3600 gaggccgcct cggcctctga gctattccag aagtagtgag gaggcttttt tggaggccta 3660 gggacgtacc caattcgccc tatagtgagt cgtattacgc gcgctcactg gccgtcgttt 3720 tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc 3780 cccctttcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt 3840 tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 3900 tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 3960 ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 4020 ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 4080 agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 4140 tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 4200 tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 4260 atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 4320 aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca 4380 ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa 4440 aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt 4500 ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca 4560 gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag 4620 ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc 4680 ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca 4740 gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt 4800 aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct 4860 gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt 4920 aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga 4980 caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact 5040 tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc 5100 acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga 5160 gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt 5220 agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga 5280 gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact 5340 ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga 5400 taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt 5460 agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca 5520 aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct 5580 ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc ttctagtgta 5640 gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct 5700 aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc 5760 aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca 5820 gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga 5880 aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg 5940 aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt 6000 cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag 6060 cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt 6120 tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt 6180 tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga 6240 ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta 6300 atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa 6360 tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcgtat 6420 gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta 6480 cgccaagcgc gcaattaacc ctcactaaag ggaacaaaag ctggagctgc aagcttaatg 6540 tagtcttatg caatactctt gtagtcttgc aacatggtaa cgatgagtta gcaacatgcc 6600 ttacaaggag agaaaaagca ccgtgcatgc cgattggtgg aagtaaggtg gtacgatcgt 6660 gccttattag gaaggcaaca gacgggtctg acatggattg gacgaaccac tgaattgccg 6720 cattgcagag atattgtatt taagtgccta gctcgataca taaacgggtc tctctggtta 6780 gaccagatct gagcctggga gctctctggc taactaggga acccactgct taagcctcaa 6840 taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac 6900 tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg cgcccgaaca 6960 gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact cggcttgctg 7020 aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa attttgacta 7080 gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg gggagaatta 7140 gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat aaattaaaac 7200 atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc ctgttagaaa 7260 catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag acaggatcag 7320 aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat caaaggatag 7380 agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac aaaagtaaga 7440 ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat gagggacaat 7500 tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc 7560 accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg 7620 ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg 7680 gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct 7740 attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca 7800 agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc 7860 tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct 7920 ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac 7980 acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa gaatgaacaa 8040 gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat aacaaattgg 8100 ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt aagaatagtt 8160 tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt atcgtttcag 8220 acccacctcc caaccccgag gggacccttg cgccttttcc aaggcagccc tgggtttgcg 8280 cagggacgcg gctgctctgg gcgtggttcc gggaaacgca gcggcgccga ccctgggtct 8340 cgcacattct tcacgtccgt tcgcagcgtc acccggatct tcgccgctac ccttgtgggc 8400 cccccggcga cgcttcctgc tccgccccta agtcgggaag gttccttgcg gttcgcggcg 8460 tgccggacgt gacaaacgga agccgcacgt ctcactagta ccctcgcaga cggacagcgc 8520 cagggagcaa tggcagcgcg ccgaccgcga tgggctgtgg ccaatagcgg ctgctcagca 8580 gggcgcgccg agagcagcgg ccgggaaggg gcggtgcggg aggcggggtg tggggcggta 8640 gtgtgggccc tgttcctgcc cgcgcggtgt tccgcattct gcaagcctcc ggagcgcacg 8700 tcggcagtcg gctccctcgt tgaccgaatc accgacctct ctccccaggg ggtacccagc 8760 tgtctagaga attctagatc ttgagacaaa tggcagtatt catccacaat tttaaaagaa 8820 aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca 8880 tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca 8940 gggacagcag agatccactt tggcgccggc tcgaggggg 8979 <210> 59 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 59 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe 35 40 45 Ser Gly Phe Ile Asp Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln 50 55 60 Asp Ile Ala Leu Ala Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu 65 70 75 80 Trp Ala Asp Arg Phe Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser 85 90 95 Gln Arg Ile Ala Phe Tyr Arg Leu Leu Asp Glu Phe Phe 100 105 <210> 60 <211> 9186 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 60 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcgccgatg gtttctacaa agatcgttat 780 gtttatcggc actttgcatc ggccgcgctc ccgattccgg aagtgcttga cattggggaa 840 tttagcgaga gcctgaccta ttgcctttca tacgagaccg agatcctgac tgtcgagtac 900 ggattgcttc ctatcggcaa aatcgtggag aagaggattg aatgtaccgt ctattcagtc 960 gataataatg ggaacatcta cacacagccc gtggctcaat ggcacgacag aggagagcag 1020 gaagtttttg aatactgtct cgaggacgga tccctcatcc gcgctactaa agatcataag 1080 tttatgaccg tggacggcca gatgctgcca attgacgaaa tttttgaacg agagctggat 1140 ctgatgagag tcgacaacct tccaaactga ttaattaaga attcgaccca gctttcttgt 1200 acaaagtggt tggtaagcct atccctaacc ctctcctcgg tctcgattct acgtagtaat 1260 gagctagcag tctcgaggtt aacgaattcc gccccccccc taacgttact ggccgaagcc 1320 gcttggaata aggccggtgt gcgcttgtct atatgttatt ttccaccata ttgccgtctt 1380 ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt gacgagcatt cctaggggtc 1440 tttcccctct cgccaaagga atgcaaggtc tgttgaatgt cgtgaaggaa gcagttcctc 1500 tggaagcttc ttgaagacaa acaacgtctg tagcgaccct ttgcaggcag cggaaccccc 1560 cacctggcga caggtgcccc tgcggccaaa agccacgtgt ataagataca cctgcaaagg 1620 cggcacaacc ccagtgccac gttgtgagtt ggatagttgt ggaaagagtc aaatggctct 1680 cctcaagcgt attcaacaag gggctgaagg atgcccagaa ggtaccccat tgtatgggat 1740 ctgatctggg gcctcggtgc acatgcttta catgtgttta gtcgaggtta aaaaaacgtc 1800 taggcccccc gaaccacggg gacgtggttt tcctttgaaa aacacgataa taccatggtg 1860 agcaagggcg aggagctgtt caccggggtg gtgcccatcc tggtcgagct ggacggcgac 1920 gtaaacggcc acaagttcag cgtgtccggc gagggcgagg gcgatgccac ctacggcaag 1980 ctgaccctga agttcatctg caccaccggc aagctgcccg tgccctggcc caccctcgtg 2040 accaccctga cctacggcgt gcagtgcttc agccgctacc ccgaccacat gaagcagcac 2100 gacttcttca agtccgccat gcccgaaggc tacgtccagg agcgcaccat cttcttcaag 2160 gacgacggca actacaagac ccgcgccgag gtgaagttcg agggcgacac cctggtgaac 2220 cgcatcgagc tgaagggcat cgacttcaag gaggacggca acatcctggg gcacaagctg 2280 gagtacaact acaacagcca caacgtctat atcatggccg acaagcagaa gaacggcatc 2340 aaggtgaact tcaagatccg ccacaacatc gaggacggca gcgtgcagct cgccgaccac 2400 taccagcaga acacccccat cggcgacggc cccgtgctgc tgcccgacaa ccactacctg 2460 agcacccagt ccgccctgag caaagacccc aacgagaagc gcgatcacat ggtcctgctg 2520 gagttcgtga ccgccgccgg gatcactctc ggcatggacg agctgtacaa gtaacaccgg 2580 tggcgcgtta agtcgacaat caacctctgg attacaaaat ttgtgaaaga ttgactggta 2640 ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc 2700 atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt 2760 ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg 2820 ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt 2880 tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct 2940 ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt 3000 cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct 3060 acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc 3120 ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct 3180 ccccgcgtcg actttaagac caatgactta caaggcagct gtagatctta gccacttttt 3240 aaaagaaaag gggggactgg aagggctaat tcactcccaa cgaagacaag atctgctttt 3300 tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact 3360 agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc 3420 ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa 3480 aatctctagc agtacgtata gtagttcatg tcatcttatt attcagtatt tataacttgc 3540 aaagaaatga atatcagaga gtgagaggaa cttgtttatt gcagcttata atggttacaa 3600 ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg 3660 tggtttgtcc aaactcatca atgtatctta tcatgtctgg ctctagctat cccgccccta 3720 actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga 3780 ctaatttttt ttatttatgc agaggccgag gccgcctcgg cctctgagct attccagaag 3840 tagtgaggag gcttttttgg aggcctaggg acgtacccaa ttcgccctat agtgagtcgt 3900 attacgcgcg ctcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta 3960 cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg 4020 cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg gacgcgccct 4080 gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg 4140 ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg 4200 gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac 4260 ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct 4320 gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt 4380 tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta taagggattt 4440 tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt 4500 ttaacaaaat attaacgctt acaatttagg tggcactttt cggggaaatg tgcgcggaac 4560 ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc 4620 ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt 4680 cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct 4740 ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga 4800 tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag 4860 cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca 4920 actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga 4980 aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag 5040 tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc 5100 ttttttgcac aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa 5160 tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt 5220 gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg 5280 gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt 5340 tattgctgat aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg 5400 gccagatggt aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat 5460 ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact 5520 gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa 5580 aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt 5640 ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt 5700 ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg 5760 tttgccggat caagagctac caactctttt tccgaaggta actggcttca gcagagcgca 5820 gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca agaactctgt 5880 agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga 5940 taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc 6000 gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact 6060 gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga 6120 caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg 6180 aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt 6240 tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt 6300 acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga 6360 ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac 6420 gaccgagcgc agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc 6480 tctccccgcg cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa 6540 agcgggcagt gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc 6600 tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca 6660 cacaggaaac agctatgacc atgattacgc caagcgcgca attaaccctc actaaaggga 6720 acaaaagctg gagctgcaag cttaatgtag tcttatgcaa tactcttgta gtcttgcaac 6780 atggtaacga tgagttagca acatgcctta caaggagaga aaaagcaccg tgcatgccga 6840 ttggtggaag taaggtggta cgatcgtgcc ttattaggaa ggcaacagac gggtctgaca 6900 tggattggac gaaccactga attgccgcat tgcagagata ttgtatttaa gtgcctagct 6960 cgatacataa acgggtctct ctggttagac cagatctgag cctgggagct ctctggctaa 7020 ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca agtagtgtgt 7080 gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta gtcagtgtgg 7140 aaaatctcta gcagtggcgc ccgaacaggg acttgaaagc gaaagggaaa ccagaggagc 7200 tctctcgacg caggactcgg cttgctgaag cgcgcacggc aagaggcgag gggcggcgac 7260 tggtgagtac gccaaaaatt ttgactagcg gaggctagaa ggagagagat gggtgcgaga 7320 gcgtcagtat taagcggggg agaattagat cgcgatggga aaaaattcgg ttaaggccag 7380 ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag ctagaacgat 7440 tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata ctgggacagc 7500 tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat acagtagcaa 7560 ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct ttagacaaga 7620 tagaggaaga gcaaaacaaa agtaagacca ccgcacagca agcggccgct gatcttcaga 7680 cctggaggag gagatatgag ggacaattgg agaagtgaat tatataaata taaagtagta 7740 aaaattgaac cattaggagt agcacccacc aaggcaaaga gaagagtggt gcagagagaa 7800 aaaagagcag tgggaatagg agctttgttc cttgggttct tgggagcagc aggaagcact 7860 atgggcgcag cgtcaatgac gctgacggta caggccagac aattattgtc tggtatagtg 7920 cagcagcaga acaatttgct gagggctatt gaggcgcaac agcatctgtt gcaactcaca 7980 gtctggggca tcaagcagct ccaggcaaga atcctggctg tggaaagata cctaaaggat 8040 caacagctcc tggggatttg gggttgctct ggaaaactca tttgcaccac tgctgtgcct 8100 tggaatgcta gttggagtaa taaatctctg gaacagattt ggaatcacac gacctggatg 8160 gagtgggaca gagaaattaa caattacaca agcttaatac actccttaat tgaagaatcg 8220 caaaaccagc aagaaaagaa tgaacaagaa ttattggaat tagataaatg ggcaagtttg 8280 tggaattggt ttaacataac aaattggctg tggtatataa aattattcat aatgatagta 8340 ggaggcttgg taggtttaag aatagttttt gctgtacttt ctatagtgaa tagagttagg 8400 cagggatatt caccattatc gtttcagacc cacctcccaa ccccgagggg acccttgcgc 8460 cttttccaag gcagccctgg gtttgcgcag ggacgcggct gctctgggcg tggttccggg 8520 aaacgcagcg gcgccgaccc tgggtctcgc acattcttca cgtccgttcg cagcgtcacc 8580 cggatcttcg ccgctaccct tgtgggcccc ccggcgacgc ttcctgctcc gcccctaagt 8640 cgggaaggtt ccttgcggtt cgcggcgtgc cggacgtgac aaacggaagc cgcacgtctc 8700 actagtaccc tcgcagacgg acagcgccag ggagcaatgg cagcgcgccg accgcgatgg 8760 gctgtggcca atagcggctg ctcagcaggg cgcgccgaga gcagcggccg ggaaggggcg 8820 gtgcgggagg cggggtgtgg ggcggtagtg tgggccctgt tcctgcccgc gcggtgttcc 8880 gcattctgca agcctccgga gcgcacgtcg gcagtcggct ccctcgttga ccgaatcacc 8940 gacctctctc cccagggggt acccagctgt ctagagaatt ctagatcttg agacaaatgg 9000 cagtattcat ccacaatttt aaaagaaaag gggggattgg ggggtacagt gcaggggaaa 9060 gaatagtaga cataatagca acagacatac aaactaaaga attacaaaaa caaattacaa 9120 aaattcaaaa ttttcgggtt tattacaggg acagcagaga tccactttgg cgccggctcg 9180 aggggg 9186 <210> 61 <211> 175 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 61 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 35 40 45 Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 50 55 60 Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Leu Ser Tyr Glu Thr Glu 65 70 75 80 Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu 85 90 95 Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile 100 105 110 Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val 115 120 125 Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp 130 135 140 His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile 145 150 155 160 Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn 165 170 175 <210> 62 <211> 9528 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 62 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcatctccc gccgtgcaca gggtgtcacg 780 ttgcaagacc tgcctgaaac cgaactgccc gctgttctgc agccggtcgc ggaggccatg 840 gatgcgatcg ctgcggccga tcttagccag acgagcgggt tcggcccatt cggaccgcaa 900 ggaatcggtc aatacactac atggcgtgat ttcatatgcg cgattgctga tccccatgtg 960 tatcactggc aaactgtgat ggacgacacc gtcagtgcgt ccgtcgcgca ggctctcgat 1020 gagctgatgc tttgggccga ggactgcccc gaagtccggc acctcgtgca cgcggatttc 1080 ggctccaaca atgtcctgac ggacaatggc cgcataacag cggtcattga ctggagcgag 1140 gcgatgttcg gggattccca atacgaggtc gccaacatct tcttctggag gccgtggttg 1200 gcttgccttt catacgagac cgagatcctg actgtcgagt acggattgct tcctatcggc 1260 aaaatcgtgg agaagaggat tgaatgtacc gtctattcag tcgataataa tgggaacatc 1320 tacacacagc ccgtggctca atggcacgac agaggagagc aggaagtttt tgaatactgt 1380 ctcgaggacg gatccctcat ccgcgctact aaagatcata agtttatgac cgtggacggc 1440 cagatgctgc caattgacga aatttttgaa cgagagctgg atctgatgag agtcgacaac 1500 cttccaaact gattaattaa gaattcgacc cagctttctt gtacaaagtg gttggtaagc 1560 ctatccctaa ccctctcctc ggtctcgatt ctacgtagta atgagctagc agtctcgagg 1620 ttaacgaatt ccgccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt 1680 gtgcgcttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc 1740 ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag 1800 gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac 1860 aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc 1920 cctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc 1980 acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca 2040 aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt 2100 gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg 2160 gggacgtggt tttcctttga aaaacacgat aataccatgg tgagcaaggg cgaggagctg 2220 ttcaccgggg tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc 2280 agcgtgtccg gcgagggcga gggcgatgcc acctacggca agctgaccct gaagttcatc 2340 tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc 2400 gtgcagtgct tcagccgcta ccccgaccac atgaagcagc acgacttctt caagtccgcc 2460 atgcccgaag gctacgtcca ggagcgcacc atcttcttca aggacgacgg caactacaag 2520 acccgcgccg aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc 2580 atcgacttca aggaggacgg caacatcctg gggcacaagc tggagtacaa ctacaacagc 2640 cacaacgtct atatcatggc cgacaagcag aagaacggca tcaaggtgaa cttcaagatc 2700 cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc actaccagca gaacaccccc 2760 atcggcgacg gccccgtgct gctgcccgac aaccactacc tgagcaccca gtccgccctg 2820 agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc 2880 gggatcactc tcggcatgga cgagctgtac aagtaacacc ggtggcgcgt taagtcgaca 2940 atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc 3000 cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta 3060 tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt 3120 ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg 3180 gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta 3240 ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt 3300 tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg 3360 cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca 3420 atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc 3480 gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgcgt cgactttaag 3540 accaatgact tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact 3600 ggaagggcta attcactccc aacgaagaca agatctgctt tttgcttgta ctgggtctct 3660 ctggttagac cagatctgag cctgggagct ctctggctaa ctagggaacc cactgcttaa 3720 gcctcaataa agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc 3780 tggtaactag agatccctca gaccctttta gtcagtgtgg aaaatctcta gcagtacgta 3840 tagtagttca tgtcatctta ttattcagta tttataactt gcaaagaaat gaatatcaga 3900 gagtgagagg aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac 3960 aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat 4020 caatgtatct tatcatgtct ggctctagct atcccgcccc taactccgcc catcccgccc 4080 ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat 4140 gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg aggctttttt 4200 ggaggcctag ggacgtaccc aattcgccct atagtgagtc gtattacgcg cgctcactgg 4260 ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 4320 cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 4380 cccaacagtt gcgcagcctg aatggcgaat gggacgcgcc ctgtagcggc gcattaagcg 4440 cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg 4500 ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc 4560 taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa 4620 aacttgatta gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc 4680 ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac 4740 tcaaccctat ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt 4800 ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa atattaacgc 4860 ttacaattta ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt 4920 ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata 4980 atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt 5040 tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc 5100 tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat 5160 ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct 5220 atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc gccgcataca 5280 ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg 5340 catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa 5400 cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg 5460 ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga 5520 cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg 5580 cgaactactt actctagctt cccggcaaca attaatagac tggatggagg cggataaagt 5640 tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg 5700 agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc 5760 ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca 5820 gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc 5880 atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat 5940 cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc 6000 agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg 6060 ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct 6120 accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa atactgttct 6180 tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct 6240 cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg 6300 gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc 6360 gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga 6420 gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg 6480 cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta 6540 tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg 6600 ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg 6660 ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat 6720 taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc 6780 agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg cgcgttggcc 6840 gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa 6900 cgcaattaat gtgagttagc tcactcatta ggcaccccag gctttacact ttatgcttcc 6960 ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa acagctatga 7020 ccatgattac gccaagcgcg caattaaccc tcactaaagg gaacaaaagc tggagctgca 7080 agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag 7140 caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg 7200 tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact 7260 gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacat aaacgggtct 7320 ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt 7380 aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac 7440 tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc 7500 gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc 7560 ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa 7620 ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg 7680 ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata 7740 aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc 7800 tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga 7860 caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc 7920 aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca 7980 aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg 8040 agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga 8100 gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata 8160 ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg 8220 acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg 8280 ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag 8340 ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt 8400 tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt 8460 aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt 8520 aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag 8580 aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata 8640 acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta 8700 agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta 8760 tcgtttcaga cccacctccc aaccccgagg ggacccttgc gccttttcca aggcagccct 8820 gggtttgcgc agggacgcgg ctgctctggg cgtggttccg ggaaacgcag cggcgccgac 8880 cctgggtctc gcacattctt cacgtccgtt cgcagcgtca cccggatctt cgccgctacc 8940 cttgtgggcc ccccggcgac gcttcctgct ccgcccctaa gtcgggaagg ttccttgcgg 9000 ttcgcggcgt gccggacgtg acaaacggaa gccgcacgtc tcactagtac cctcgcagac 9060 ggacagcgcc agggagcaat ggcagcgcgc cgaccgcgat gggctgtggc caatagcggc 9120 tgctcagcag ggcgcgccga gagcagcggc cgggaagggg cggtgcggga ggcggggtgt 9180 ggggcggtag tgtgggccct gttcctgccc gcgcggtgtt ccgcattctg caagcctccg 9240 gagcgcacgt cggcagtcgg ctccctcgtt gaccgaatca ccgacctctc tccccagggg 9300 gtacccagct gtctagagaa ttctagatct tgagacaaat ggcagtattc atccacaatt 9360 ttaaaagaaa aggggggatt ggggggtaca gtgcagggga aagaatagta gacataatag 9420 caacagacat acaaactaaa gaattacaaa aacaaattac aaaaattcaa aattttcggg 9480 tttattacag ggacagcaga gatccacttt ggcgccggct cgaggggg 9528 <210> 63 <211> 289 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 63 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Ile Ser Arg Arg Ala Gln Gly Val Thr Leu Gln 35 40 45 Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu Gln Pro Val Ala Glu 50 55 60 Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser Gln Thr Ser Gly Phe 65 70 75 80 Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr Thr Thr Trp Arg Asp 85 90 95 Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr His Trp Gln Thr Val 100 105 110 Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln Ala Leu Asp Glu Leu 115 120 125 Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg His Leu Val His Ala 130 135 140 Asp Phe Gly Ser Asn Asn Val Leu Thr Asp Asn Gly Arg Ile Thr Ala 145 150 155 160 Val Ile Asp Trp Ser Glu Ala Met Phe Gly Asp Ser Gln Tyr Glu Val 165 170 175 Ala Asn Ile Phe Phe Trp Arg Pro Trp Leu Ala Cys Leu Ser Tyr Glu 180 185 190 Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile 195 200 205 Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly 210 215 220 Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln 225 230 235 240 Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr 245 250 255 Lys Asp His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp 260 265 270 Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro 275 280 285 Asn <210> 64 <211> 4596 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 64 ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga 60 taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga 120 gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca 180 cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaata cgcgtaccgc 240 tagccaggaa gagtttgtag aaacgcaaaa aggccatccg tcaggatggc cttctgctta 300 gtttgatgcc tggcagttta tggcgggcgt cctgcccgcc accctccggg ccgttgcttc 360 acaacgatca aatccgctcc cggcggattt gtcctactca ggagagcgtt caccgacaaa 420 caacagataa aacgaaaggc ccagtcttcc gactgagcct ttcgttttat ttgatgcctg 480 gcagttccct actctcgcgt taacgctagc atggatgttt tcccagtcac gacgttgtaa 540 aacgacggcc agtcttaagc tcgggcccca aataatgatt ttattttgac tgatagtgac 600 ctgttcgttg caacaaattg atgagcaatg cttttttata atgccaactt tgtacaaaaa 660 agcaggctcc gaattcaccg gtgagaccgt cgacctgcag actggctgtg tataagggag 720 cctgacattt atattcccca gaacatcagg ttaatggcgt ttttgatgtc attttcgcgg 780 tggctgagat cagccacttc ttccccgata acggagaccg gcacactggc catatcggtg 840 gtcatcatgc gccagctttc atccccgata tgcaccaccg ggtaaagttc acgggagact 900 ttatctgaca gcagacgtgc actggccagg gggatcacca tccgtcgccc gggcgtgtca 960 ataatatcac tctgtacatc cacaaacaga cgataacggc tctctctttt ataggtgtaa 1020 accttaaact gcatttcacc agcccctgtt ctcgtcagca aaagagccgt tcatttcaat 1080 aaaccgggcg acctcagcca tcccttcctg attttccgct ttccagcgtt cggcacgcag 1140 acgacgggct tcattctgca tggttgtgct taccagaccg gagatattga catcatatat 1200 gccttgagca actgatagct gtcgctgtca actgtcactg taatacgctg cttcatagca 1260 tacctctttt tgacatactt cgggtataca tatcagtata tattcttata ccgcaaaaat 1320 cagcgcgcaa atacgcatac tgttatctgg cttttagtaa gccggatcca gatctttacg 1380 ccccgccctg ccactcatcg cagtactgtt gtaattcatt aagcattctg ccgacatgga 1440 agccatcaca aacggcatga tgaacctgaa tcgccagcgg catcagcacc ttgtcgcctt 1500 gcgtataata tttgcccatg gtgaaaacgg gggcgaagaa gttgtccata ttggccacgt 1560 ttaaatcaaa actggtgaaa ctcacccagg gattggctga gacgaaaaac atattctcaa 1620 taaacccttt agggaaatag gccaggtttt caccgtaaca cgccacatct tgcgaatata 1680 tgtgtagaaa ctgccggaaa tcgtcgtggt attcactcca gagcgatgaa aaggtttcag 1740 tttgctcatg gaaaacggtg taacaagggt gaacactatc ccatatcacc agctcaccgt 1800 ctttcattgc catacggaat tccggatgag cattcatcag gcgggcaaga atgtgaataa 1860 aggccggata aaacttgtgc ttatttttct ttacggtctt taaaaaggcc gtaatatcca 1920 gctgaacggt ctggttatag gtacattgag caactgactg aaatgcctca aaatgttctt 1980 tacgatgcca ttgggatata tcaacggtgg tatatccagt gatttttttc tccattttag 2040 cttccttagc tcctgaaaat ctcgacggat cctaactcaa aatccacaca ttatacgagc 2100 cggaagcata aagtgtaaag cctggggtgc ctaatgcggc cgcggtctca tgcctttcat 2160 acgagaccga gatcctgact gtcgagtacg gattgcttcc tatcggcaaa atcgtggaga 2220 agaggattga atgtaccgtc tattcagtcg ataataatgg gaacatctac acacagcccg 2280 tggctcaatg gcacgacaga ggagagcagg aagtttttga atactgtctc gaggacggat 2340 ccctcatccg cgctactaaa gatcataagt ttatgaccgt ggacggccag atgctgccaa 2400 ttgacgaaat ttttgaacga gagctggatc tgatgagagt cgacaacctt ccaaactgat 2460 taattaagaa ttcgacccag ctttcttgta caaagttggc attataaaaa ataattgctc 2520 atcaatttgt tgcaacgaac aggtcactat cagtcaaaat aaaatcatta tttgccatcc 2580 agctgatatc ccctatagtg agtcgtatta catggtcata gctgtttcct ggcagctctg 2640 gcccgtgtct caaaatctct gatgttacat tgcacaagat aaaaatatat catcatgcct 2700 cctctagacc agccaggaca gaaatgcctc gacttcgctg ctgcccaagg ttgccgggtg 2760 acgcacaccg tggaaacgga tgaaggcacg aacccagtgg acataagcct gttcggttcg 2820 taagctgtaa tgcaagtagc gtatgcgctc acgcaactgg tccagaacct tgaccgaacg 2880 cagcggtggt aacggcgcag tggcggtttt catggcttgt tatgactgtt tttttggggt 2940 acagtctatg cctcgggcat ccaagcagca agcgcgttac gccgtgggtc gatgtttgat 3000 gttatggagc agcaacgatg ttacgcagca gggcagtcgc cctaaaacaa agttaaacat 3060 catgagggaa gcggtgatcg ccgaagtatc gactcaacta tcagaggtag ttggcgtcat 3120 cgagcgccat ctcgaaccga cgttgctggc cgtacatttg tacggctccg cagtggatgg 3180 cggcctgaag ccacacagtg atattgattt gctggttacg gtgaccgtaa ggcttgatga 3240 aacaacgcgg cgagctttga tcaacgacct tttggaaact tcggcttccc ctggagagag 3300 cgagattctc cgcgctgtag aagtcaccat tgttgtgcac gacgacatca ttccgtggcg 3360 ttatccagct aagcgcgaac tgcaatttgg agaatggcag cgcaatgaca ttcttgcagg 3420 tatcttcgag ccagccacga tcgacattga tctggctatc ttgctgacaa aagcaagaga 3480 acatagcgtt gccttggtag gtccagcggc ggaggaactc tttgatccgg ttcctgaaca 3540 ggatctattt gaggcgctaa atgaaacctt aacgctatgg aactcgccgc ccgactgggc 3600 tggcgatgag cgaaatgtag tgcttacgtt gtcccgcatt tggtacagcg cagtaaccgg 3660 caaaatcgcg ccgaaggatg tcgctgccga ctgggcaatg gagcgcctgc cggcccagta 3720 tcagcccgtc atacttgaag ctagacaggc ttatcttgga caagaagaag atcgcttggc 3780 ctcgcgcgca gatcagttgg aagaatttgt ccactacgtg aaaggcgaga tcaccaaggt 3840 agtcggcaaa taaccctcga gccacccatg accaaaatcc cttaacgtga gttacgcgtc 3900 gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt 3960 tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt 4020 gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat 4080 accaaatact gtccttctag tgtagccgta gttaggccac cacttcaaga actctgtagc 4140 accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa 4200 gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg 4260 ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag 4320 atacctacag cgtgagcatt gagaaagcgc cacgcttccc gaagggagaa aggcggacag 4380 gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa 4440 cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt 4500 gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg 4560 gttcctggcc ttttgctggc cttttgctca catgtt 4596 <210> 65 <211> 4405 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 65 ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga 60 taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga 120 gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca 180 cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaata cgcgtaccgc 240 tagccaggaa gagtttgtag aaacgcaaaa aggccatccg tcaggatggc cttctgctta 300 gtttgatgcc tggcagttta tggcgggcgt cctgcccgcc accctccggg ccgttgcttc 360 acaacgatca aatccgctcc cggcggattt gtcctactca ggagagcgtt caccgacaaa 420 caacagataa aacgaaaggc ccagtcttcc gactgagcct ttcgttttat ttgatgcctg 480 gcagttccct actctcgcgt taacgctagc atggatgttt tcccagtcac gacgttgtaa 540 aacgacggcc agtcttaagc tcgggcccca aataatgatt ttattttgac tgatagtgac 600 ctgttcgttg caacaaattg atgagcaatg cttttttata atgccaactt tgtacaaaaa 660 agcaggctcc gaattcaccg gtgccgccac catgattaag atcgctacgc ggaagtacct 720 ggggaaacag aacgtctacg acataggtgt ggagcgcgat cacaactttg ctctgaaaaa 780 tggatttatc gccagcaact gagaccgtcg acctgcagac tggctgtgta taagggagcc 840 tgacatttat attccccaga acatcaggtt aatggcgttt ttgatgtcat tttcgcggtg 900 gctgagatca gccacttctt ccccgataac ggagaccggc acactggcca tatcggtggt 960 catcatgcgc cagctttcat ccccgatatg caccaccggg taaagttcac gggagacttt 1020 atctgacagc agacgtgcac tggccagggg gatcaccatc cgtcgcccgg gcgtgtcaat 1080 aatatcactc tgtacatcca caaacagacg ataacggctc tctcttttat aggtgtaaac 1140 cttaaactgc atttcaccag cccctgttct cgtcagcaaa agagccgttc atttcaataa 1200 accgggcgac ctcagccatc ccttcctgat tttccgcttt ccagcgttcg gcacgcagac 1260 gacgggcttc attctgcatg gttgtgctta ccagaccgga gatattgaca tcatatatgc 1320 cttgagcaac tgatagctgt cgctgtcaac tgtcactgta atacgctgct tcatagcata 1380 cctctttttg acatacttcg ggtatacata tcagtatata ttcttatacc gcaaaaatca 1440 gcgcgcaaat acgcatactg ttatctggct tttagtaagc cggatccaga tctttacgcc 1500 ccgccctgcc actcatcgca gtactgttgt aattcattaa gcattctgcc gacatggaag 1560 ccatcacaaa cggcatgatg aacctgaatc gccagcggca tcagcacctt gtcgccttgc 1620 gtataatatt tgcccatggt gaaaacgggg gcgaagaagt tgtccatatt ggccacgttt 1680 aaatcaaaac tggtgaaact cacccaggga ttggctgaga cgaaaaacat attctcaata 1740 aaccctttag ggaaataggc caggttttca ccgtaacacg ccacatcttg cgaatatatg 1800 tgtagaaact gccggaaatc gtcgtggtat tcactccaga gcgatgaaaa ggtttcagtt 1860 tgctcatgga aaacggtgta acaagggtga acactatccc atatcaccag ctcaccgtct 1920 ttcattgcca tacggaattc cggatgagca ttcatcaggc gggcaagaat gtgaataaag 1980 gccggataaa acttgtgctt atttttcttt acggtcttta aaaaggccgt aatatccagc 2040 tgaacggtct ggttataggt acattgagca actgactgaa atgcctcaaa atgttcttta 2100 cgatgccatt gggatatatc aacggtggta tatccagtga tttttttctc cattttagct 2160 tccttagctc ctgaaaatct cgacggatcc taactcaaaa tccacacatt atacgagccg 2220 gaagcataaa gtgtaaagcc tggggtgcct aatgcggccg cggtctcatt aattaagaat 2280 tcgacccagc tttcttgtac aaagttggca ttataaaaaa taattgctca tcaatttgtt 2340 gcaacgaaca ggtcactatc agtcaaaata aaatcattat ttgccatcca gctgatatcc 2400 cctatagtga gtcgtattac atggtcatag ctgtttcctg gcagctctgg cccgtgtctc 2460 aaaatctctg atgttacatt gcacaagata aaaatatatc atcatgcctc ctctagacca 2520 gccaggacag aaatgcctcg acttcgctgc tgcccaaggt tgccgggtga cgcacaccgt 2580 ggaaacggat gaaggcacga acccagtgga cataagcctg ttcggttcgt aagctgtaat 2640 gcaagtagcg tatgcgctca cgcaactggt ccagaacctt gaccgaacgc agcggtggta 2700 acggcgcagt ggcggttttc atggcttgtt atgactgttt ttttggggta cagtctatgc 2760 ctcgggcatc caagcagcaa gcgcgttacg ccgtgggtcg atgtttgatg ttatggagca 2820 gcaacgatgt tacgcagcag ggcagtcgcc ctaaaacaaa gttaaacatc atgagggaag 2880 cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc gagcgccatc 2940 tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc ggcctgaagc 3000 cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa acaacgcggc 3060 gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc gagattctcc 3120 gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt tatccagcta 3180 agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt atcttcgagc 3240 cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa catagcgttg 3300 ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag gatctatttg 3360 aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct ggcgatgagc 3420 gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc aaaatcgcgc 3480 cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat cagcccgtca 3540 tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc tcgcgcgcag 3600 atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta gtcggcaaat 3660 aaccctcgag ccacccatga ccaaaatccc ttaacgtgag ttacgcgtcg ttccactgag 3720 cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa 3780 tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag 3840 agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg 3900 tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat 3960 acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta 4020 ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg 4080 gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc 4140 gtgagcattg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa 4200 gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc 4260 tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt 4320 caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct 4380 tttgctggcc ttttgctcac atgtt 4405 <210> 66 <211> 4659 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 66 ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga 60 taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga 120 gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca 180 cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaata cgcgtaccgc 240 tagccaggaa gagtttgtag aaacgcaaaa aggccatccg tcaggatggc cttctgctta 300 gtttgatgcc tggcagttta tggcgggcgt cctgcccgcc accctccggg ccgttgcttc 360 acaacgatca aatccgctcc cggcggattt gtcctactca ggagagcgtt caccgacaaa 420 caacagataa aacgaaaggc ccagtcttcc gactgagcct ttcgttttat ttgatgcctg 480 gcagttccct actctcgcgt taacgctagc atggatgttt tcccagtcac gacgttgtaa 540 aacgacggcc agtcttaagc tcgggcccca aataatgatt ttattttgac tgatagtgac 600 ctgttcgttg caacaaattg atgagcaatg cttttttata atgccaactt tgtacaaaaa 660 agcaggctcc gaattcaccg gtgagaccgt cgacctgcag actggctgtg tataagggag 720 cctgacattt atattcccca gaacatcagg ttaatggcgt ttttgatgtc attttcgcgg 780 tggctgagat cagccacttc ttccccgata acggagaccg gcacactggc catatcggtg 840 gtcatcatgc gccagctttc atccccgata tgcaccaccg ggtaaagttc acgggagact 900 ttatctgaca gcagacgtgc actggccagg gggatcacca tccgtcgccc gggcgtgtca 960 ataatatcac tctgtacatc cacaaacaga cgataacggc tctctctttt ataggtgtaa 1020 accttaaact gcatttcacc agcccctgtt ctcgtcagca aaagagccgt tcatttcaat 1080 aaaccgggcg acctcagcca tcccttcctg attttccgct ttccagcgtt cggcacgcag 1140 acgacgggct tcattctgca tggttgtgct taccagaccg gagatattga catcatatat 1200 gccttgagca actgatagct gtcgctgtca actgtcactg taatacgctg cttcatagca 1260 tacctctttt tgacatactt cgggtataca tatcagtata tattcttata ccgcaaaaat 1320 cagcgcgcaa atacgcatac tgttatctgg cttttagtaa gccggatcca gatctttacg 1380 ccccgccctg ccactcatcg cagtactgtt gtaattcatt aagcattctg ccgacatgga 1440 agccatcaca aacggcatga tgaacctgaa tcgccagcgg catcagcacc ttgtcgcctt 1500 gcgtataata tttgcccatg gtgaaaacgg gggcgaagaa gttgtccata ttggccacgt 1560 ttaaatcaaa actggtgaaa ctcacccagg gattggctga gacgaaaaac atattctcaa 1620 taaacccttt agggaaatag gccaggtttt caccgtaaca cgccacatct tgcgaatata 1680 tgtgtagaaa ctgccggaaa tcgtcgtggt attcactcca gagcgatgaa aaggtttcag 1740 tttgctcatg gaaaacggtg taacaagggt gaacactatc ccatatcacc agctcaccgt 1800 ctttcattgc catacggaat tccggatgag cattcatcag gcgggcaaga atgtgaataa 1860 aggccggata aaacttgtgc ttatttttct ttacggtctt taaaaaggcc gtaatatcca 1920 gctgaacggt ctggttatag gtacattgag caactgactg aaatgcctca aaatgttctt 1980 tacgatgcca ttgggatata tcaacggtgg tatatccagt gatttttttc tccattttag 2040 cttccttagc tcctgaaaat ctcgacggat cctaactcaa aatccacaca ttatacgagc 2100 cggaagcata aagtgtaaag cctggggtgc ctaatgcggc cgcggtctca tgccttagct 2160 tcggtaccga gatactcacc gttgagtacg gaccactgcc aattggcaag atcgttagcg 2220 aagagattaa ttgttccgtc tactctgttg atcctgaggg cagggtatac acacaggcta 2280 ttgctcagtg gcatgacaga ggcgagcagg aggttcttga gtacgagctg gaggatgggt 2340 cagttatccg ggcgacatca gatcaccgat tcctgactac agattatcag ctgctcgcca 2400 ttgaagaaat cttcgcaaga cagttggatc tcctgactct ggaaaatatc aagcagaccg 2460 aggaagctct ggacaaccac cgcctgcctt ttccgctgct tgatgccggc accattaagt 2520 gattaattaa gaattcgacc cagctttctt gtacaaagtt ggcattataa aaaataattg 2580 ctcatcaatt tgttgcaacg aacaggtcac tatcagtcaa aataaaatca ttatttgcca 2640 tccagctgat atcccctata gtgagtcgta ttacatggtc atagctgttt cctggcagct 2700 ctggcccgtg tctcaaaatc tctgatgtta cattgcacaa gataaaaata tatcatcatg 2760 cctcctctag accagccagg acagaaatgc ctcgacttcg ctgctgccca aggttgccgg 2820 gtgacgcaca ccgtggaaac ggatgaaggc acgaacccag tggacataag cctgttcggt 2880 tcgtaagctg taatgcaagt agcgtatgcg ctcacgcaac tggtccagaa ccttgaccga 2940 acgcagcggt ggtaacggcg cagtggcggt tttcatggct tgttatgact gtttttttgg 3000 ggtacagtct atgcctcggg catccaagca gcaagcgcgt tacgccgtgg gtcgatgttt 3060 gatgttatgg agcagcaacg atgttacgca gcagggcagt cgccctaaaa caaagttaaa 3120 catcatgagg gaagcggtga tcgccgaagt atcgactcaa ctatcagagg tagttggcgt 3180 catcgagcgc catctcgaac cgacgttgct ggccgtacat ttgtacggct ccgcagtgga 3240 tggcggcctg aagccacaca gtgatattga tttgctggtt acggtgaccg taaggcttga 3300 tgaaacaacg cggcgagctt tgatcaacga ccttttggaa acttcggctt cccctggaga 3360 gagcgagatt ctccgcgctg tagaagtcac cattgttgtg cacgacgaca tcattccgtg 3420 gcgttatcca gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg acattcttgc 3480 aggtatcttc gagccagcca cgatcgacat tgatctggct atcttgctga caaaagcaag 3540 agaacatagc gttgccttgg taggtccagc ggcggaggaa ctctttgatc cggttcctga 3600 acaggatcta tttgaggcgc taaatgaaac cttaacgcta tggaactcgc cgcccgactg 3660 ggctggcgat gagcgaaatg tagtgcttac gttgtcccgc atttggtaca gcgcagtaac 3720 cggcaaaatc gcgccgaagg atgtcgctgc cgactgggca atggagcgcc tgccggccca 3780 gtatcagccc gtcatacttg aagctagaca ggcttatctt ggacaagaag aagatcgctt 3840 ggcctcgcgc gcagatcagt tggaagaatt tgtccactac gtgaaaggcg agatcaccaa 3900 ggtagtcggc aaataaccct cgagccaccc atgaccaaaa tcccttaacg tgagttacgc 3960 gtcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt 4020 ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg 4080 tttgccggat caagagctac caactctttt tccgaaggta actggcttca gcagagcgca 4140 gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt 4200 agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga 4260 taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc 4320 gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact 4380 gagataccta cagcgtgagc attgagaaag cgccacgctt cccgaaggga gaaaggcgga 4440 caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg 4500 aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt 4560 tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt 4620 acggttcctg gccttttgct ggccttttgc tcacatgtt 4659 <210> 67 <211> 4405 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 67 ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga 60 taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga 120 gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca 180 cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaata cgcgtaccgc 240 tagccaggaa gagtttgtag aaacgcaaaa aggccatccg tcaggatggc cttctgctta 300 gtttgatgcc tggcagttta tggcgggcgt cctgcccgcc accctccggg ccgttgcttc 360 acaacgatca aatccgctcc cggcggattt gtcctactca ggagagcgtt caccgacaaa 420 caacagataa aacgaaaggc ccagtcttcc gactgagcct ttcgttttat ttgatgcctg 480 gcagttccct actctcgcgt taacgctagc atggatgttt tcccagtcac gacgttgtaa 540 aacgacggcc agtcttaagc tcgggcccca aataatgatt ttattttgac tgatagtgac 600 ctgttcgttg caacaaattg atgagcaatg cttttttata atgccaactt tgtacaaaaa 660 agcaggctcc gaattcaccg gtgccgccac catggtgaaa gtgattggcc ggcgatcact 720 cggcgtccag aggattttcg atatcggcct cccgcaggac cacaattttc tgctcgctaa 780 tggtgctatt gcagctaact gagaccgtcg acctgcagac tggctgtgta taagggagcc 840 tgacatttat attccccaga acatcaggtt aatggcgttt ttgatgtcat tttcgcggtg 900 gctgagatca gccacttctt ccccgataac ggagaccggc acactggcca tatcggtggt 960 catcatgcgc cagctttcat ccccgatatg caccaccggg taaagttcac gggagacttt 1020 atctgacagc agacgtgcac tggccagggg gatcaccatc cgtcgcccgg gcgtgtcaat 1080 aatatcactc tgtacatcca caaacagacg ataacggctc tctcttttat aggtgtaaac 1140 cttaaactgc atttcaccag cccctgttct cgtcagcaaa agagccgttc atttcaataa 1200 accgggcgac ctcagccatc ccttcctgat tttccgcttt ccagcgttcg gcacgcagac 1260 gacgggcttc attctgcatg gttgtgctta ccagaccgga gatattgaca tcatatatgc 1320 cttgagcaac tgatagctgt cgctgtcaac tgtcactgta atacgctgct tcatagcata 1380 cctctttttg acatacttcg ggtatacata tcagtatata ttcttatacc gcaaaaatca 1440 gcgcgcaaat acgcatactg ttatctggct tttagtaagc cggatccaga tctttacgcc 1500 ccgccctgcc actcatcgca gtactgttgt aattcattaa gcattctgcc gacatggaag 1560 ccatcacaaa cggcatgatg aacctgaatc gccagcggca tcagcacctt gtcgccttgc 1620 gtataatatt tgcccatggt gaaaacgggg gcgaagaagt tgtccatatt ggccacgttt 1680 aaatcaaaac tggtgaaact cacccaggga ttggctgaga cgaaaaacat attctcaata 1740 aaccctttag ggaaataggc caggttttca ccgtaacacg ccacatcttg cgaatatatg 1800 tgtagaaact gccggaaatc gtcgtggtat tcactccaga gcgatgaaaa cgtttcagtt 1860 tgctcatgga aaacggtgta acaagggtga acactatccc atatcaccag ctcaccgtct 1920 ttcattgcca tacggaattc cggatgagca ttcatcaggc gggcaagaat gtgaataaag 1980 gccggataaa acttgtgctt atttttcttt acggtcttta aaaaggccgt aatatccagc 2040 tgaacggtct ggttataggt acattgagca actgactgaa atgcctcaaa atgttcttta 2100 cgatgccatt gggatatatc aacggtggta tatccagtga tttttttctc cattttagct 2160 tccttagctc ctgaaaatct cgacggatcc taactcaaaa tccacacatt atacgagccg 2220 gaagcataaa gtgtaaagcc tggggtgcct aatgcggccg cggtctcatt aattaagaat 2280 tcgacccagc tttcttgtac aaagttggca ttataaaaaa taattgctca tcaatttgtt 2340 gcaacgaaca ggtcactatc agtcaaaata aaatcattat ttgccatcca gctgatatcc 2400 cctatagtga gtcgtattac atggtcatag ctgtttcctg gcagctctgg cccgtgtctc 2460 aaaatctctg atgttacatt gcacaagata aaaatatatc atcatgcctc ctctagacca 2520 gccaggacag aaatgcctcg acttcgctgc tgcccaaggt tgccgggtga cgcacaccgt 2580 ggaaacggat gaaggcacga acccagtgga cataagcctg ttcggttcgt aagctgtaat 2640 gcaagtagcg tatgcgctca cgcaactggt ccagaacctt gaccgaacgc agcggtggta 2700 acggcgcagt ggcggttttc atggcttgtt atgactgttt ttttggggta cagtctatgc 2760 ctcgggcatc caagcagcaa gcgcgttacg ccgtgggtcg atgtttgatg ttatggagca 2820 gcaacgatgt tacgcagcag ggcagtcgcc ctaaaacaaa gttaaacatc atgagggaag 2880 cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc gagcgccatc 2940 tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc ggcctgaagc 3000 cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa acaacgcggc 3060 gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc gagattctcc 3120 gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt tatccagcta 3180 agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt atcttcgagc 3240 cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa catagcgttg 3300 ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag gatctatttg 3360 aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct ggcgatgagc 3420 gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc aaaatcgcgc 3480 cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat cagcccgtca 3540 tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc tcgcgcgcag 3600 atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta gtcggcaaat 3660 aaccctcgag ccacccatga ccaaaatccc ttaacgtgag ttacgcgtcg ttccactgag 3720 cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa 3780 tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag 3840 agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg 3900 tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat 3960 acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta 4020 ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg 4080 gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc 4140 gtgagcattg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa 4200 gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc 4260 tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt 4320 caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct 4380 tttgctggcc ttttgctcac atgtt 4405 <210> 68 <211> 4607 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 68 ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga 60 taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga 120 gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca 180 cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaata cgcgtaccgc 240 tagccaggaa gagtttgtag aaacgcaaaa aggccatccg tcaggatggc cttctgctta 300 gtttgatgcc tggcagttta tggcgggcgt cctgcccgcc accctccggg ccgttgcttc 360 acaacgatca aatccgctcc cggcggattt gtcctactca ggagagcgtt caccgacaaa 420 caacagataa aacgaaaggc ccagtcttcc gactgagcct ttcgttttat ttgatgcctg 480 gcagttccct actctcgcgt taacgctagc atggatgttt tcccagtcac gacgttgtaa 540 aacgacggcc agtcttaagc tcgggcccca aataatgatt ttattttgac tgatagtgac 600 ctgttcgttg caacaaattg atgagcaatg cttttttata atgccaactt tgtacaaaaa 660 agcaggctcc gaattcaccg gtgagacctc gacctgcaga ctggctgtgt ataagggagc 720 ctgacattta tattccccag aacatcaggt taatggcgtt tttgatgtca ttttcgcggt 780 ggctgagatc agccacttct tccccgataa cggagaccgg cacactggcc atatcggtgg 840 tcatcatgcg ccagctttca tccccgatat gcaccaccgg gtaaagttca cgggagactt 900 tatctgacag cagacgtgca ctggccaggg ggatcaccat ccgtcgcccg ggcgtgtcaa 960 taatatcact ctgtacatcc acaaacagac gataacggct ctctctttta taggtgtaaa 1020 ccttaaactg catttcacca gcccctgttc tcgtcagcaa aagagccgtt catttcaata 1080 aaccgggcga cctcagccat cccttcctga ttttccgctt tccagcgttc ggcacgcaga 1140 cgacgggctt cattctgcat ggttgtgctt accagaccgg agatattgac atcatatatg 1200 ccttgagcaa ctgatagctg tcgctgtcaa ctgtcactgt aatacgctgc ttcatagcat 1260 acctcttttt gacatacttc gggtatacat atcagtatat attcttatac cgcaaaaatc 1320 agcgcgcaaa tacgcatact gttatctggc ttttagtaag ccggatccag atctttacgc 1380 cccgccctgc cactcatcgc agtactgttg taattcatta agcattctgc cgacatggaa 1440 gccatcacaa acggcatgat gaacctgaat cgccagcggc atcagcacct tgtcgccttg 1500 cgtataatat ttgcccatgg tgaaaacggg ggcgaagaag ttgtccatat tggccacgtt 1560 taaatcaaaa ctggtgaaac tcacccaggg attggctgag acgaaaaaca tattctcaat 1620 aaacccttta gggaaatagg ccaggttttc accgtaacac gccacatctt gcgaatatat 1680 gtgtagaaac tgccggaaat cgtcgtggta ttcactccag agcgatgaaa aggtttcagt 1740 ttgctcatgg aaaacggtgt aacaagggtg aacactatcc catatcacca gctcaccgtc 1800 tttcattgcc atacggaatt ccggatgagc attcatcagg cgggcaagaa tgtgaataaa 1860 ggccggataa aacttgtgct tatttttctt tacggtcttt aaaaaggccg taatatccag 1920 ctgaacggtc tggttatagg tacattgagc aactgactga aatgcctcaa aatgttcttt 1980 acgatgccat tgggatatat caacggtggt atatccagtg atttttttct ccattttagc 2040 ttccttagct cctgaaaatc tcgacggatc ctaactcaaa atccacacat tatacgagcc 2100 ggaagcataa agtgtaaagc ctggggtgcc taatgcggcc gcggtctcat gtatcagtgg 2160 cgactccctg atctcactcg caagcactgg aaagcgagtt agcatcaagg acttgctgga 2220 cgaaaaggat ttcgaaattt gggcaatcaa tgagcagacc atgaaactgg agtctgcaaa 2280 ggtgtcccgg gtgttttgca cgggtaagaa gcttgtttat atccttaaaa ctagactggg 2340 ccggacgatc aaagccaccg cgaaccacag attcttgaca atcgacgggt ggaaacggct 2400 ggacgaactg agcttgaagg agcacatcgc ccttcctcgg aagctcgagt catcttccct 2460 gcagctgtga ttaattaaga attcgaccca gctttcttgt acaaagttgg cattataaaa 2520 aataattgct catcaatttg ttgcaacgaa caggtcacta tcagtcaaaa taaaatcatt 2580 atttgccatc cagctgatat cccctatagt gagtcgtatt acatggtcat agctgtttcc 2640 tggcagctct ggcccgtgtc tcaaaatctc tgatgttaca ttgcacaaga taaaaatata 2700 tcatcatgcc tcctctagac cagccaggac agaaatgcct cgacttcgct gctgcccaag 2760 gttgccgggt gacgcacacc gtggaaacgg atgaaggcac gaacccagtg gacataagcc 2820 tgttcggttc gtaagctgta atgcaagtag cgtatgcgct cacgcaactg gtccagaacc 2880 ttgaccgaac gcagcggtgg taacggcgca gtggcggttt tcatggcttg ttatgactgt 2940 ttttttgggg tacagtctat gcctcgggca tccaagcagc aagcgcgtta cgccgtgggt 3000 cgatgtttga tgttatggag cagcaacgat gttacgcagc agggcagtcg ccctaaaaca 3060 aagttaaaca tcatgaggga agcggtgatc gccgaagtat cgactcaact atcagaggta 3120 gttggcgtca tcgagcgcca tctcgaaccg acgttgctgg ccgtacattt gtacggctcc 3180 gcagtggatg gcggcctgaa gccacacagt gatattgatt tgctggttac ggtgaccgta 3240 aggcttgatg aaacaacgcg gcgagctttg atcaacgacc ttttggaaac ttcggcttcc 3300 cctggagaga gcgagattct ccgcgctgta gaagtcacca ttgttgtgca cgacgacatc 3360 attccgtggc gttatccagc taagcgcgaa ctgcaatttg gagaatggca gcgcaatgac 3420 attcttgcag gtatcttcga gccagccacg atcgacattg atctggctat cttgctgaca 3480 aaagcaagag aacatagcgt tgccttggta ggtccagcgg cggaggaact ctttgatccg 3540 gttcctgaac aggatctatt tgaggcgcta aatgaaacct taacgctatg gaactcgccg 3600 cccgactggg ctggcgatga gcgaaatgta gtgcttacgt tgtcccgcat ttggtacagc 3660 gcagtaaccg gcaaaatcgc gccgaaggat gtcgctgccg actgggcaat ggagcgcctg 3720 ccggcccagt atcagcccgt catacttgaa gctagacagg cttatcttgg acaagaagaa 3780 gatcgcttgg cctcgcgcgc agatcagttg gaagaatttg tccactacgt gaaaggcgag 3840 atcaccaagg tagtcggcaa ataaccctcg agccacccat gaccaaaatc ccttaacgtg 3900 agttacgcgt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga 3960 gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg 4020 gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc 4080 agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag 4140 aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc 4200 agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg 4260 cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac 4320 accgaactga gatacctaca gcgtgagcat tgagaaagcg ccacgcttcc cgaagggaga 4380 aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt 4440 ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag 4500 cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg 4560 gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgtt 4607 <210> 69 <211> 4444 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 69 ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga 60 taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga 120 gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca 180 cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaata cgcgtaccgc 240 tagccaggaa gagtttgtag aaacgcaaaa aggccatccg tcaggatggc cttctgctta 300 gtttgatgcc tggcagttta tggcgggcgt cctgcccgcc accctccggg ccgttgcttc 360 acaacgatca aatccgctcc cggcggattt gtcctactca ggagagcgtt caccgacaaa 420 caacagataa aacgaaaggc ccagtcttcc gactgagcct ttcgttttat ttgatgcctg 480 gcagttccct actctcgcgt taacgctagc atggatgttt tcccagtcac gacgttgtaa 540 aacgacggcc agtcttaagc tcgggcccca aataatgatt ttattttgac tgatagtgac 600 ctgttcgttg caacaaattg atgagcaatg cttttttata atgccaactt tgtacaaaaa 660 agcaggctcc gaattcaccg gtgccgccac catgagtccc gaaatcgaaa agctctctca 720 gagcgatata tattgggact ccatcgtaag cataacagag acgggggtcg aggaggtgtt 780 cgatctgaca gttcctgggc ctcataattt cgtagcgaac gacatcattg tacataactg 840 agaccgtcga cctgcagact ggctgtgtat aagggagcct gacatttata ttccccagaa 900 catcaggtta atggcgtttt tgatgtcatt ttcgcggtgg ctgagatcag ccacttcttc 960 cccgataacg gagaccggca cactggccat atcggtggtc atcatgcgcc agctttcatc 1020 cccgatatgc accaccgggt aaagttcacg ggagacttta tctgacagca gacgtgcact 1080 ggccaggggg atcaccatcc gtcgcccggg cgtgtcaata atatcactct gtacatccac 1140 aaacagacga taacggctct ctcttttata ggtgtaaacc ttaaactgca tttcaccagc 1200 ccctgttctc gtcagcaaaa gagccgttca tttcaataaa ccgggcgacc tcagccatcc 1260 cttcctgatt ttccgctttc cagcgttcgg cacgcagacg acgggcttca ttctgcatgg 1320 ttgtgcttac cagaccggag atattgacat catatatgcc ttgagcaact gatagctgtc 1380 gctgtcaact gtcactgtaa tacgctgctt catagcatac ctctttttga catacttcgg 1440 gtatacatat cagtatatat tcttataccg caaaaatcag cgcgcaaata cgcatactgt 1500 tatctggctt ttagtaagcc ggatccagat ctttacgccc cgccctgcca ctcatcgcag 1560 tactgttgta attcattaag cattctgccg acatggaagc catcacaaac ggcatgatga 1620 acctgaatcg ccagcggcat cagcaccttg tcgccttgcg tataatattt gcccatggtg 1680 aaaacggggg cgaagaagtt gtccatattg gccacgttta aatcaaaact ggtgaaactc 1740 acccagggat tggctgagac gaaaaacata ttctcaataa accctttagg gaaataggcc 1800 aggttttcac cgtaacacgc cacatcttgc gaatatatgt gtagaaactg ccggaaatcg 1860 tcgtggtatt cactccagag cgatgaaaag gtttcagttt gctcatggaa aacggtgtaa 1920 caagggtgaa cactatccca tatcaccagc tcaccgtctt tcattgccat acggaattcc 1980 ggatgagcat tcatcaggcg ggcaagaatg tgaataaagg ccggataaaa cttgtgctta 2040 tttttcttta cggtctttaa aaaggccgta atatccagct gaacggtctg gttataggta 2100 cattgagcaa ctgactgaaa tgcctcaaaa tgttctttac gatgccattg ggatatatca 2160 acggtggtat atccagtgat ttttttctcc attttagctt ccttagctcc tgaaaatctc 2220 gacggatcct aactcaaaat ccacacatta tacgagccgg aagcataaag tgtaaagcct 2280 ggggtgccta atgcggccgc ggtctcatta attaagaatt cgacccagct ttcttgtaca 2340 aagttggcat tataaaaaat aattgctcat caatttgttg caacgaacag gtcactatca 2400 gtcaaaataa aatcattatt tgccatccag ctgatatccc ctatagtgag tcgtattaca 2460 tggtcatagc tgtttcctgg cagctctggc ccgtgtctca aaatctctga tgttacattg 2520 cacaagataa aaatatatca tcatgcctcc tctagaccag ccaggacaga aatgcctcga 2580 cttcgctgct gcccaaggtt gccgggtgac gcacaccgtg gaaacggatg aaggcacgaa 2640 cccagtggac ataagcctgt tcggttcgta agctgtaatg caagtagcgt atgcgctcac 2700 gcaactggtc cagaaccttg accgaacgca gcggtggtaa cggcgcagtg gcggttttca 2760 tggcttgtta tgactgtttt tttggggtac agtctatgcc tcgggcatcc aagcagcaag 2820 cgcgttacgc cgtgggtcga tgtttgatgt tatggagcag caacgatgtt acgcagcagg 2880 gcagtcgccc taaaacaaag ttaaacatca tgagggaagc ggtgatcgcc gaagtatcga 2940 ctcaactatc agaggtagtt ggcgtcatcg agcgccatct cgaaccgacg ttgctggccg 3000 tacatttgta cggctccgca gtggatggcg gcctgaagcc acacagtgat attgatttgc 3060 tggttacggt gaccgtaagg cttgatgaaa caacgcggcg agctttgatc aacgaccttt 3120 tggaaacttc ggcttcccct ggagagagcg agattctccg cgctgtagaa gtcaccattg 3180 ttgtgcacga cgacatcatt ccgtggcgtt atccagctaa gcgcgaactg caatttggag 3240 aatggcagcg caatgacatt cttgcaggta tcttcgagcc agccacgatc gacattgatc 3300 tggctatctt gctgacaaaa gcaagagaac atagcgttgc cttggtaggt ccagcggcgg 3360 aggaactctt tgatccggtt cctgaacagg atctatttga ggcgctaaat gaaaccttaa 3420 cgctatggaa ctcgccgccc gactgggctg gcgatgagcg aaatgtagtg cttacgttgt 3480 cccgcatttg gtacagcgca gtaaccggca aaatcgcgcc gaaggatgtc gctgccgact 3540 gggcaatgga gcgcctgccg gcccagtatc agcccgtcat acttgaagct agacaggctt 3600 atcttggaca agaagaagat cgcttggcct cgcgcgcaga tcagttggaa gaatttgtcc 3660 actacgtgaa aggcgagatc accaaggtag tcggcaaata accctcgagc cacccatgac 3720 caaaatccct taacgtgagt tacgcgtcgt tccactgagc gtcagacccc gtagaaaaga 3780 tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa 3840 aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga 3900 aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt 3960 taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt 4020 taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat 4080 agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct 4140 tggagcgaac gacctacacc gaactgagat acctacagcg tgagcattga gaaagcgcca 4200 cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag 4260 agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc 4320 gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga 4380 aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca 4440 tgtt 4444 <210> 70 <211> 9204 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 70 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggtgag caagggcgag 660 gcagtgatca aggagttcat gcggttcaag gtgcacatgg agggctccat gaacggccac 720 gagttcgaga tcgagggcga gggcgagggc cgcccctacg agggcaccca gaccgccaag 780 tgcctttcat acgagaccga gatcctgact gtcgagtacg gattgcttcc tatcggcaaa 840 atcgtggaga agaggattga atgtaccgtc tattcagtcg ataataatgg gaacatctac 900 acacagcccg tggctcaatg gcacgacaga ggagagcagg aagtttttga atactgtctc 960 gaggacggat ccctcatccg cgctactaaa gatcataagt ttatgaccgt ggacggccag 1020 atgctgccaa ttgacgaaat ttttgaacga gagctggatc tgatgagagt cgacaacctt 1080 ccaaacggtg gaggggggtc aggctctgcg cagctggaaa aggagcttca agccctcgaa 1140 aaaaagttgg cccagctcga gtgggagaac caggctctgg agaaagaact ggcccagtga 1200 ttaattaaga attcgaccca gctttcttgt acaaagtggt tggtaagcct atccctaacc 1260 ctctcctcgg tctcgattct acgtagtaat gagctagcag tctcgaggtt aacgaattcc 1320 gccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt gcgcttgtct 1380 atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc 1440 ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc 1500 tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg 1560 tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcccc tgcggccaaa 1620 agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt 1680 ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg 1740 atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta 1800 catgtgttta gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt 1860 tcctttgaaa aacacgataa taccatggcc atgagcgagc tgattaagga gaacatgcac 1920 atgaagctgt acatggaggg caccgtggac aaccatcact tcaagtgcac atccgagggc 1980 gaaggcaagc cctacgaggg cacccagacc atgagaatca aggtggtcga gggcggccct 2040 ctccccttcg ccttcgacat cctggctact agcttcctct acggcagcaa gaccttcatc 2100 aaccacaccc agggcatccc cgacttcttc aagcagtcct tccctgaggg cttcacatgg 2160 gagagagtca ccacatacga agacgggggc gtgctgaccg ctacccagga caccagcctc 2220 caggacggct gcctcatcta caacgtcaag atcagagggg tgaacttcac atccaacggc 2280 cctgtgatgc agaagaaaac actcggctgg gaggccttca ccgagacgct gtaccccgct 2340 gacggcggcc tggaaggcag aaacgacatg gccctgaagc tcgtgggcgg gagccatctg 2400 atcgcaaaca tcaagaccac atatagatcc aagaaacccg ctaagaacct caagatgcct 2460 ggcgtctact atgtggacta cagactggaa agaatcaagg aggccaacaa cgagacctac 2520 gtcgagcagc acgaggtggc agtggccaga tactgcgacc tccctagcaa actggggcac 2580 aagcttaatt aacaccggtg gcgcgttaag tcgacaatca acctctggat tacaaaattt 2640 gtgaaagatt gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg 2700 ctttaatgcc tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt 2760 ataaatcctg gttgctgtct ctttatgagg agttgtggcc cgttgtcagg caacgtggcg 2820 tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg gggcattgcc accacctgtc 2880 agctcctttc cgggactttc gctttccccc tccctattgc cacggcggaa ctcatcgccg 2940 cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt 3000 tgtcggggaa atcatcgtcc tttccttggc tgctcgcctg tgttgccacc tggattctgc 3060 gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg 3120 gcctgctgcc ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga 3180 tctccctttg ggccgcctcc ccgcgtcgac tttaagacca atgacttaca aggcagctgt 3240 agatcttagc cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaacg 3300 aagacaagat ctgctttttg cttgtactgg gtctctctgg ttagaccaga tctgagcctg 3360 ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt 3420 gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc 3480 cttttagtca gtgtggaaaa tctctagcag tacgtatagt agttcatgtc atcttattat 3540 tcagtattta taacttgcaa agaaatgaat atcagagagt gagaggaact tgtttattgc 3600 agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt 3660 ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggct 3720 ctagctatcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat 3780 tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc 3840 tctgagctat tccagaagta gtgaggaggc ttttttggag gcctagggac gtacccaatt 3900 cgccctatag tgagtcgtat tacgcgcgct cactggccgt cgttttacaa cgtcgtgact 3960 gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct 4020 ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg 4080 gcgaatggga cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca 4140 gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct 4200 ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt 4260 tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac 4320 gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct 4380 ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt 4440 ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac 4500 aaaaatttaa cgcgaatttt aacaaaatat taacgcttac aatttaggtg gcacttttcg 4560 gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc 4620 gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag 4680 tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt 4740 tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt 4800 gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga 4860 acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat 4920 tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga 4980 gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag 5040 tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg 5100 accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg 5160 ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt 5220 agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg 5280 gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc 5340 ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg 5400 tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac 5460 ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact 5520 gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa 5580 acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa 5640 aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg 5700 atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc 5760 gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac 5820 tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt agttaggcca 5880 ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt 5940 ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc 6000 ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg 6060 aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc 6120 cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac 6180 gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct 6240 ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc 6300 cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt 6360 tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac 6420 cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg 6480 cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca gctggcacga 6540 caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga gttagctcac 6600 tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt 6660 gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca agcgcgcaat 6720 taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc ttatgcaata 6780 ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca aggagagaaa 6840 aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt attaggaagg 6900 caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg cagagatatt 6960 gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca gatctgagcc 7020 tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga 7080 gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaga 7140 cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac ttgaaagcga 7200 aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg cgcacggcaa 7260 gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga ggctagaagg 7320 agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg cgatgggaaa 7380 aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata gtatgggcaa 7440 gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca gaaggctgta 7500 gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa cttagatcat 7560 tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata aaagacacca 7620 aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc gcacagcaag 7680 cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag aagtgaatta 7740 tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa ggcaaagaga 7800 agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct tgggttcttg 7860 ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca ggccagacaa 7920 ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga ggcgcaacag 7980 catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat cctggctgtg 8040 gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg aaaactcatt 8100 tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga acagatttgg 8160 aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag cttaatacac 8220 tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt attggaatta 8280 gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg gtatataaaa 8340 ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc tgtactttct 8400 atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca cctcccaacc 8460 ccgaggggac ccttgcgcct tttccaaggc agccctgggt ttgcgcaggg acgcggctgc 8520 tctgggcgtg gttccgggaa acgcagcggc gccgaccctg ggtctcgcac attcttcacg 8580 tccgttcgca gcgtcacccg gatcttcgcc gctacccttg tgggcccccc ggcgacgctt 8640 cctgctccgc ccctaagtcg ggaaggttcc ttgcggttcg cggcgtgccg gacgtgacaa 8700 acggaagccg cacgtctcac tagtaccctc gcagacggac agcgccaggg agcaatggca 8760 gcgcgccgac cgcgatgggc tgtggccaat agcggctgct cagcagggcg cgccgagagc 8820 agcggccggg aaggggcggt gcgggaggcg gggtgtgggg cggtagtgtg ggccctgttc 8880 ctgcccgcgc ggtgttccgc attctgcaag cctccggagc gcacgtcggc agtcggctcc 8940 ctcgttgacc gaatcaccga cctctctccc cagggggtac ccagctgtct agagaattct 9000 agatcttgag acaaatggca gtattcatcc acaattttaa aagaaaaggg gggattgggg 9060 ggtacagtgc aggggaaaga atagtagaca taatagcaac agacatacaa actaaagaat 9120 tacaaaaaca aattacaaaa attcaaaatt ttcgggttta ttacagggac agcagagatc 9180 cactttggcg ccggctcgag gggg 9204 <210> 71 <211> 185 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 71 Met Val Ser Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys 1 5 10 15 Val His Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 20 25 30 Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Cys Leu 35 40 45 Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile 50 55 60 Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp 65 70 75 80 Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg 85 90 95 Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile 100 105 110 Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln Met Leu 115 120 125 Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp 130 135 140 Asn Leu Pro Asn Gly Gly Gly Gly Ser Gly Ser Ala Gln Leu Glu Lys 145 150 155 160 Glu Leu Gln Ala Leu Glu Lys Lys Leu Ala Gln Leu Glu Trp Glu Asn 165 170 175 Gln Ala Leu Glu Lys Glu Leu Ala Gln 180 185 <210> 72 <211> 9444 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 72 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggctca actgaagaag 660 aaactccagg ccaataagaa agaactggca cagctgaagt ggaagctgca ggcactgaaa 720 aagaagctgg cacagggcgg aggaggctca ggcagtatga ttaagatcgc tacgcggaag 780 tacctgggga aacagaacgt ctacgacata ggtgtggagc gcgatcacaa ctttgctctg 840 aaaaatggat ttatcgccag caactgcctg aaggtgacca agggtggccc cctgcccttc 900 tcctgggaca tcctgtcccc tcagttcatg tacggctcca gggccttcac caagcacccc 960 gccgacatcc ccgactacta taagcagtcc ttccccgagg gcttcaagtg ggagcgcgtg 1020 atgaacttcg aggacggcgg cgccgtgacc gtgacccagg acacctccct ggaggacggc 1080 accctgatct acaaggtgaa gctccgcggc accaacttcc ctcctgacgg ccccgtaatg 1140 cagaagaaga caatgggctg ggaagcgtcc accgagcggt tgtaccccga ggacggcgtg 1200 ctgaagggcg acattaagat ggccctgcgc ctgaaggacg gcggccgcta cctggcggac 1260 ttcaagacca cctacaaggc caagaagccc gtgcagatgc ccggcgccta caacgtcgac 1320 cgcaagttgg acatcacctc ccacaacgag gactacaccg tggtggaaca gtacgaacgc 1380 tccgagggcc gccactccac cggcggcatg gacgagctgt acaagtgatt aattaagaat 1440 tcgacccagc tttcttgtac aaagtggttg gtaagcctat ccctaaccct ctcctcggtc 1500 tcgattctac gtagtaatga gctagcagtc tcgaggttaa cgaattccgc ccccccccta 1560 acgttactgg ccgaagccgc ttggaataag gccggtgtgc gcttgtctat atgttatttt 1620 ccaccatatt gccgtctttt ggcaatgtga gggcccggaa acctggccct gtcttcttga 1680 cgagcattcc taggggtctt tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg 1740 tgaaggaagc agttcctctg gaagcttctt gaagacaaac aacgtctgta gcgacccttt 1800 gcaggcagcg gaacccccca cctggcgaca ggtgcccctg cggccaaaag ccacgtgtat 1860 aagatacacc tgcaaaggcg gcacaacccc agtgccacgt tgtgagttgg atagttgtgg 1920 aaagagtcaa atggctctcc tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg 1980 taccccattg tatgggatct gatctggggc ctcggtgcac atgctttaca tgtgtttagt 2040 cgaggttaaa aaaacgtcta ggccccccga accacgggga cgtggttttc ctttgaaaaa 2100 cacgataata ccatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg 2160 gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc 2220 gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg 2280 ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag ccgctacccc 2340 gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag 2400 cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag 2460 ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac 2520 atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat catggccgac 2580 aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga ggacggcagc 2640 gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg 2700 cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc 2760 gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag 2820 ctgtacaagt aacaccggtg gcgcgttaag tcgacaatca acctctggat tacaaaattt 2880 gtgaaagatt gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg 2940 ctttaatgcc tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt 3000 ataaatcctg gttgctgtct ctttatgagg agttgtggcc cgttgtcagg caacgtggcg 3060 tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg gggcattgcc accacctgtc 3120 agctcctttc cgggactttc gctttccccc tccctattgc cacggcggaa ctcatcgccg 3180 cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt 3240 tgtcggggaa atcatcgtcc tttccttggc tgctcgcctg tgttgccacc tggattctgc 3300 gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg 3360 gcctgctgcc ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga 3420 tctccctttg ggccgcctcc ccgcgtcgac tttaagacca atgacttaca aggcagctgt 3480 agatcttagc cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaacg 3540 aagacaagat ctgctttttg cttgtactgg gtctctctgg ttagaccaga tctgagcctg 3600 ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt 3660 gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc 3720 cttttagtca gtgtggaaaa tctctagcag tacgtatagt agttcatgtc atcttattat 3780 tcagtattta taacttgcaa agaaatgaat atcagagagt gagaggaact tgtttattgc 3840 agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt 3900 ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggct 3960 ctagctatcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat 4020 tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc 4080 tctgagctat tccagaagta gtgaggaggc ttttttggag gcctagggac gtacccaatt 4140 cgccctatag tgagtcgtat tacgcgcgct cactggccgt cgttttacaa cgtcgtgact 4200 gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct 4260 ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg 4320 gcgaatggga cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca 4380 gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct 4440 ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt 4500 tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac 4560 gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct 4620 ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt 4680 ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac 4740 aaaaatttaa cgcgaatttt aacaaaatat taacgcttac aatttaggtg gcacttttcg 4800 gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc 4860 gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag 4920 tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt 4980 tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt 5040 gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga 5100 acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat 5160 tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga 5220 gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag 5280 tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg 5340 accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg 5400 ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt 5460 agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg 5520 gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc 5580 ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg 5640 tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac 5700 ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact 5760 gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa 5820 acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa 5880 aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg 5940 atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc 6000 gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac 6060 tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt agttaggcca 6120 ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt 6180 ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc 6240 ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg 6300 aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc 6360 cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac 6420 gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct 6480 ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc 6540 cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt 6600 tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac 6660 cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg 6720 cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca gctggcacga 6780 caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga gttagctcac 6840 tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt 6900 gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca agcgcgcaat 6960 taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc ttatgcaata 7020 ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca aggagagaaa 7080 aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt attaggaagg 7140 caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg cagagatatt 7200 gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca gatctgagcc 7260 tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga 7320 gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaga 7380 cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac ttgaaagcga 7440 aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg cgcacggcaa 7500 gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga ggctagaagg 7560 agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg cgatgggaaa 7620 aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata gtatgggcaa 7680 gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca gaaggctgta 7740 gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa cttagatcat 7800 tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata aaagacacca 7860 aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc gcacagcaag 7920 cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag aagtgaatta 7980 tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa ggcaaagaga 8040 agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct tgggttcttg 8100 ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca ggccagacaa 8160 ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga ggcgcaacag 8220 catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat cctggctgtg 8280 gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg aaaactcatt 8340 tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga acagatttgg 8400 aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag cttaatacac 8460 tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt attggaatta 8520 gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg gtatataaaa 8580 ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc tgtactttct 8640 atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca cctcccaacc 8700 ccgaggggac ccttgcgcct tttccaaggc agccctgggt ttgcgcaggg acgcggctgc 8760 tctgggcgtg gttccgggaa acgcagcggc gccgaccctg ggtctcgcac attcttcacg 8820 tccgttcgca gcgtcacccg gatcttcgcc gctacccttg tgggcccccc ggcgacgctt 8880 cctgctccgc ccctaagtcg ggaaggttcc ttgcggttcg cggcgtgccg gacgtgacaa 8940 acggaagccg cacgtctcac tagtaccctc gcagacggac agcgccaggg agcaatggca 9000 gcgcgccgac cgcgatgggc tgtggccaat agcggctgct cagcagggcg cgccgagagc 9060 agcggccggg aaggggcggt gcgggaggcg gggtgtgggg cggtagtgtg ggccctgttc 9120 ctgcccgcgc ggtgttccgc attctgcaag cctccggagc gcacgtcggc agtcggctcc 9180 ctcgttgacc gaatcaccga cctctctccc cagggggtac ccagctgtct agagaattct 9240 agatcttgag acaaatggca gtattcatcc acaattttaa aagaaaaggg gggattgggg 9300 ggtacagtgc aggggaaaga atagtagaca taatagcaac agacatacaa actaaagaat 9360 tacaaaaaca aattacaaaa attcaaaatt ttcgggttta ttacagggac agcagagatc 9420 cactttggcg ccggctcgag gggg 9444 <210> 73 <211> 261 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 73 Met Ala Gln Leu Lys Lys Lys Leu Gln Ala Asn Lys Lys Glu Leu Ala 1 5 10 15 Gln Leu Lys Trp Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln Gly 20 25 30 Gly Gly Gly Ser Gly Ser Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu 35 40 45 Gly Lys Gln Asn Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe 50 55 60 Ala Leu Lys Asn Gly Phe Ile Ala Ser Asn Cys Leu Lys Val Thr Lys 65 70 75 80 Gly Gly Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro Gln Phe Met 85 90 95 Tyr Gly Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile Pro Asp Tyr 100 105 110 Tyr Lys Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn 115 120 125 Phe Glu Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr Ser Leu Glu 130 135 140 Asp Gly Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro 145 150 155 160 Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser 165 170 175 Thr Glu Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly Asp Ile Lys 180 185 190 Met Ala Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu Ala Asp Phe Lys 195 200 205 Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Met Pro Gly Ala Tyr Asn 210 215 220 Val Asp Arg Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Val 225 230 235 240 Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His Ser Thr Gly Gly Met 245 250 255 Asp Glu Leu Tyr Lys 260 <210> 74 <211> 9210 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 74 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggtgag caagggcgag 660 gcagtgatca aggagttcat gcggttcaag gtgcacatgg agggctccat gaacggccac 720 gagttcgaga tcgagggcga gggcgagggc cgcccctacg agggcaccca gaccgccaag 780 ctgaagtgcc tttcatacga gaccgagatc ctgactgtcg agtacggatt gcttcctatc 840 ggcaaaatcg tggagaagag gattgaatgt accgtctatt cagtcgataa taatgggaac 900 atctacacac agcccgtggc tcaatggcac gacagaggag agcaggaagt ttttgaatac 960 tgtctcgagg acggatccct catccgcgct actaaagatc ataagtttat gaccgtggac 1020 ggccagatgc tgccaattga cgaaattttt gaacgagagc tggatctgat gagagtcgac 1080 aaccttccaa acggtggagg ggggtcaggc tctgcgcagc tggaaaagga gcttcaagcc 1140 ctcgaaaaaa agttggccca gctcgagtgg gagaaccagg ctctggagaa agaactggcc 1200 cagtgattaa ttaagaattc gacccagctt tcttgtacaa agtggttggt aagcctatcc 1260 ctaaccctct cctcggtctc gattctacgt agtaatgagc tagcagtctc gaggttaacg 1320 aattccgccc cccccctaac gttactggcc gaagccgctt ggaataaggc cggtgtgcgc 1380 ttgtctatat gttattttcc accatattgc cgtcttttgg caatgtgagg gcccggaaac 1440 ctggccctgt cttcttgacg agcattccta ggggtctttc ccctctcgcc aaaggaatgc 1500 aaggtctgtt gaatgtcgtg aaggaagcag ttcctctgga agcttcttga agacaaacaa 1560 cgtctgtagc gaccctttgc aggcagcgga accccccacc tggcgacagg tgcccctgcg 1620 gccaaaagcc acgtgtataa gatacacctg caaaggcggc acaaccccag tgccacgttg 1680 tgagttggat agttgtggaa agagtcaaat ggctctcctc aagcgtattc aacaaggggc 1740 tgaaggatgc ccagaaggta ccccattgta tgggatctga tctggggcct cggtgcacat 1800 gctttacatg tgtttagtcg aggttaaaaa aacgtctagg ccccccgaac cacggggacg 1860 tggttttcct ttgaaaaaca cgataatacc atggccatga gcgagctgat taaggagaac 1920 atgcacatga agctgtacat ggagggcacc gtggacaacc atcacttcaa gtgcacatcc 1980 gagggcgaag gcaagcccta cgagggcacc cagaccatga gaatcaaggt ggtcgagggc 2040 ggccctctcc ccttcgcctt cgacatcctg gctactagct tcctctacgg cagcaagacc 2100 ttcatcaacc acacccaggg catccccgac ttcttcaagc agtccttccc tgagggcttc 2160 acatgggaga gagtcaccac atacgaagac gggggcgtgc tgaccgctac ccaggacacc 2220 agcctccagg acggctgcct catctacaac gtcaagatca gaggggtgaa cttcacatcc 2280 aacggccctg tgatgcagaa gaaaacactc ggctgggagg ccttcaccga gacgctgtac 2340 cccgctgacg gcggcctgga aggcagaaac gacatggccc tgaagctcgt gggcgggagc 2400 catctgatcg caaacatcaa gaccacatat agatccaaga aacccgctaa gaacctcaag 2460 atgcctggcg tctactatgt ggactacaga ctggaaagaa tcaaggaggc caacaacgag 2520 acctacgtcg agcagcacga ggtggcagtg gccagatact gcgacctccc tagcaaactg 2580 gggcacaagc ttaattaaca ccggtggcgc gttaagtcga caatcaacct ctggattaca 2640 aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat 2700 acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct 2760 ccttgtataa atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac 2820 gtggcgtggt gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca 2880 cctgtcagct cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca 2940 tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg 3000 tggtgttgtc ggggaaatca tcgtcctttc cttggctgct cgcctgtgtt gccacctgga 3060 ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt 3120 cccgcggcct gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga 3180 gtcggatctc cctttgggcc gcctccccgc gtcgacttta agaccaatga cttacaaggc 3240 agctgtagat cttagccact ttttaaaaga aaagggggga ctggaagggc taattcactc 3300 ccaacgaaga caagatctgc tttttgcttg tactgggtct ctctggttag accagatctg 3360 agcctgggag ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc 3420 ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac tctggtaact agagatccct 3480 cagacccttt tagtcagtgt ggaaaatctc tagcagtacg tatagtagtt catgtcatct 3540 tattattcag tatttataac ttgcaaagaa atgaatatca gagagtgaga ggaacttgtt 3600 tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc 3660 atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt 3720 ctggctctag ctatcccgcc cctaactccg cccatcccgc ccctaactcc gcccagttcc 3780 gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc cgaggccgcc 3840 tcggcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct agggacgtac 3900 ccaattcgcc ctatagtgag tcgtattacg cgcgctcact ggccgtcgtt ttacaacgtc 3960 gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg 4020 ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc 4080 tgaatggcga atgggacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta 4140 cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc 4200 cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt 4260 tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg 4320 gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca 4380 cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct 4440 attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga 4500 tttaacaaaa atttaacgcg aattttaaca aaatattaac gcttacaatt taggtggcac 4560 ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat 4620 gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag 4680 tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc 4740 tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc 4800 acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc 4860 cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc 4920 ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt 4980 ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt 5040 atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat 5100 cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct 5160 tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat 5220 gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc 5280 ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg 5340 ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc 5400 tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta 5460 cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc 5520 ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga 5580 tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat 5640 gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat 5700 caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa 5760 accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa 5820 ggtaactggc ttcagcagag cgcagatacc aaatactgtt cttctagtgt agccgtagtt 5880 aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt 5940 accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata 6000 gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt 6060 ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac 6120 gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga 6180 gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg 6240 ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa 6300 aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat 6360 gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc 6420 tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga 6480 agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg 6540 gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta 6600 gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta tgttgtgtgg 6660 aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt acgccaagcg 6720 cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagcttaat gtagtcttat 6780 gcaatactct tgtagtcttg caacatggta acgatgagtt agcaacatgc cttacaagga 6840 gagaaaaagc accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg tgccttatta 6900 ggaaggcaac agacgggtct gacatggatt ggacgaacca ctgaattgcc gcattgcaga 6960 gatattgtat ttaagtgcct agctcgatac ataaacgggt ctctctggtt agaccagatc 7020 tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg 7080 ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc 7140 ctcagaccct tttagtcagt gtggaaaatc tctagcagtg gcgcccgaac agggacttga 7200 aagcgaaagg gaaaccagag gagctctctc gacgcaggac tcggcttgct gaagcgcgca 7260 cggcaagagg cgaggggcgg cgactggtga gtacgccaaa aattttgact agcggaggct 7320 agaaggagag agatgggtgc gagagcgtca gtattaagcg ggggagaatt agatcgcgat 7380 gggaaaaaat tcggttaagg ccagggggaa agaaaaaata taaattaaaa catatagtat 7440 gggcaagcag ggagctagaa cgattcgcag ttaatcctgg cctgttagaa acatcagaag 7500 gctgtagaca aatactggga cagctacaac catcccttca gacaggatca gaagaactta 7560 gatcattata taatacagta gcaaccctct attgtgtgca tcaaaggata gagataaaag 7620 acaccaagga agctttagac aagatagagg aagagcaaaa caaaagtaag accaccgcac 7680 agcaagcggc cgctgatctt cagacctgga ggaggagata tgagggacaa ttggagaagt 7740 gaattatata aatataaagt agtaaaaatt gaaccattag gagtagcacc caccaaggca 7800 aagagaagag tggtgcagag agaaaaaaga gcagtgggaa taggagcttt gttccttggg 7860 ttcttgggag cagcaggaag cactatgggc gcagcgtcaa tgacgctgac ggtacaggcc 7920 agacaattat tgtctggtat agtgcagcag cagaacaatt tgctgagggc tattgaggcg 7980 caacagcatc tgttgcaact cacagtctgg ggcatcaagc agctccaggc aagaatcctg 8040 gctgtggaaa gatacctaaa ggatcaacag ctcctgggga tttggggttg ctctggaaaa 8100 ctcatttgca ccactgctgt gccttggaat gctagttgga gtaataaatc tctggaacag 8160 atttggaatc acacgacctg gatggagtgg gacagagaaa ttaacaatta cacaagctta 8220 atacactcct taattgaaga atcgcaaaac cagcaagaaa agaatgaaca agaattattg 8280 gaattagata aatgggcaag tttgtggaat tggtttaaca taacaaattg gctgtggtat 8340 ataaaattat tcataatgat agtaggaggc ttggtaggtt taagaatagt ttttgctgta 8400 ctttctatag tgaatagagt taggcaggga tattcaccat tatcgtttca gacccacctc 8460 ccaaccccga ggggaccctt gcgccttttc caaggcagcc ctgggtttgc gcagggacgc 8520 ggctgctctg ggcgtggttc cgggaaacgc agcggcgccg accctgggtc tcgcacattc 8580 ttcacgtccg ttcgcagcgt cacccggatc ttcgccgcta cccttgtggg ccccccggcg 8640 acgcttcctg ctccgcccct aagtcgggaa ggttccttgc ggttcgcggc gtgccggacg 8700 tgacaaacgg aagccgcacg tctcactagt accctcgcag acggacagcg ccagggagca 8760 atggcagcgc gccgaccgcg atgggctgtg gccaatagcg gctgctcagc agggcgcgcc 8820 gagagcagcg gccgggaagg ggcggtgcgg gaggcggggt gtggggcggt agtgtgggcc 8880 ctgttcctgc ccgcgcggtg ttccgcattc tgcaagcctc cggagcgcac gtcggcagtc 8940 ggctccctcg ttgaccgaat caccgacctc tctccccagg gggtacccag ctgtctagag 9000 aattctagat cttgagacaa atggcagtat tcatccacaa ttttaaaaga aaagggggga 9060 ttggggggta cagtgcaggg gaaagaatag tagacataat agcaacagac atacaaacta 9120 aagaattaca aaaacaaatt acaaaaattc aaaattttcg ggtttattac agggacagca 9180 gagatccact ttggcgccgg ctcgaggggg 9210 <210> 75 <211> 187 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 75 Met Val Ser Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys 1 5 10 15 Val His Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 20 25 30 Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 35 40 45 Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu 50 55 60 Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 65 70 75 80 Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 85 90 95 Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 100 105 110 Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 115 120 125 Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 130 135 140 Val Asp Asn Leu Pro Asn Gly Gly Gly Gly Ser Gly Ser Ala Gln Leu 145 150 155 160 Glu Lys Glu Leu Gln Ala Leu Glu Lys Lys Leu Ala Gln Leu Glu Trp 165 170 175 Glu Asn Gln Ala Leu Glu Lys Glu Leu Ala Gln 180 185 <210> 76 <211> 9438 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 76 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggctca actgaagaag 660 aaactccagg ccaataagaa agaactggca cagctgaagt ggaagctgca ggcactgaaa 720 aagaagctgg cacagggcgg aggaggctca ggcagtatga ttaagatcgc tacgcggaag 780 tacctgggga aacagaacgt ctacgacata ggtgtggagc gcgatcacaa ctttgctctg 840 aaaaatggat ttatcgccag caactgcgtg accaagggtg gccccctgcc cttctcctgg 900 gacatcctgt cccctcagtt catgtacggc tccagggcct tcaccaagca ccccgccgac 960 atccccgact actataagca gtccttcccc gagggcttca agtgggagcg cgtgatgaac 1020 ttcgaggacg gcggcgccgt gaccgtgacc caggacacct ccctggagga cggcaccctg 1080 atctacaagg tgaagctccg cggcaccaac ttccctcctg acggccccgt aatgcagaag 1140 aagacaatgg gctgggaagc gtccaccgag cggttgtacc ccgaggacgg cgtgctgaag 1200 ggcgacatta agatggccct gcgcctgaag gacggcggcc gctacctggc ggacttcaag 1260 accacctaca aggccaagaa gcccgtgcag atgcccggcg cctacaacgt cgaccgcaag 1320 ttggacatca cctcccacaa cgaggactac accgtggtgg aacagtacga acgctccgag 1380 ggccgccact ccaccggcgg catggacgag ctgtacaagt gattaattaa gaattcgacc 1440 cagctttctt gtacaaagtg gttggtaagc ctatccctaa ccctctcctc ggtctcgatt 1500 ctacgtagta atgagctagc agtctcgagg ttaacgaatt ccgccccccc cctaacgtta 1560 ctggccgaag ccgcttggaa taaggccggt gtgcgcttgt ctatatgtta ttttccacca 1620 tattgccgtc ttttggcaat gtgagggccc ggaaacctgg ccctgtcttc ttgacgagca 1680 ttcctagggg tctttcccct ctcgccaaag gaatgcaagg tctgttgaat gtcgtgaagg 1740 aagcagttcc tctggaagct tcttgaagac aaacaacgtc tgtagcgacc ctttgcaggc 1800 agcggaaccc cccacctggc gacaggtgcc cctgcggcca aaagccacgt gtataagata 1860 cacctgcaaa ggcggcacaa ccccagtgcc acgttgtgag ttggatagtt gtggaaagag 1920 tcaaatggct ctcctcaagc gtattcaaca aggggctgaa ggatgcccag aaggtacccc 1980 attgtatggg atctgatctg gggcctcggt gcacatgctt tacatgtgtt tagtcgaggt 2040 taaaaaaacg tctaggcccc ccgaaccacg gggacgtggt tttcctttga aaaacacgat 2100 aataccatgg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag 2160 ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc 2220 acctacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg 2280 cccaccctcg tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac 2340 atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc 2400 atcttcttca aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac 2460 accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg 2520 gggcacaagc tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag 2580 aagaacggca tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag 2640 ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac 2700 aaccactacc tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac 2760 atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac 2820 aagtaacacc ggtggcgcgt taagtcgaca atcaacctct ggattacaaa atttgtgaaa 2880 gattgactgg tattcttaac tatgttgctc cttttacgct atgtggatac gctgctttaa 2940 tgcctttgta tcatgctatt gcttcccgta tggctttcat tttctcctcc ttgtataaat 3000 cctggttgct gtctctttat gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt 3060 gcactgtgtt tgctgacgca acccccactg gttggggcat tgccaccacc tgtcagctcc 3120 tttccgggac tttcgctttc cccctcccta ttgccacggc ggaactcatc gccgcctgcc 3180 ttgcccgctg ctggacaggg gctcggctgt tgggcactga caattccgtg gtgttgtcgg 3240 ggaaatcatc gtcctttcct tggctgctcg cctgtgttgc cacctggatt ctgcgcggga 3300 cgtccttctg ctacgtccct tcggccctca atccagcgga ccttccttcc cgcggcctgc 3360 tgccggctct gcggcctctt ccgcgtcttc gccttcgccc tcagacgagt cggatctccc 3420 tttgggccgc ctccccgcgt cgactttaag accaatgact tacaaggcag ctgtagatct 3480 tagccacttt ttaaaagaaa aggggggact ggaagggcta attcactccc aacgaagaca 3540 agatctgctt tttgcttgta ctgggtctct ctggttagac cagatctgag cctgggagct 3600 ctctggctaa ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca 3660 agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta 3720 gtcagtgtgg aaaatctcta gcagtacgta tagtagttca tgtcatctta ttattcagta 3780 tttataactt gcaaagaaat gaatatcaga gagtgagagg aacttgttta ttgcagctta 3840 taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact 3900 gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggctctagct 3960 atcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg 4020 ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc ggcctctgag 4080 ctattccaga agtagtgagg aggctttttt ggaggcctag ggacgtaccc aattcgccct 4140 atagtgagtc gtattacgcg cgctcactgg ccgtcgtttt acaacgtcgt gactgggaaa 4200 accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta 4260 atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat 4320 gggacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga 4380 ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg 4440 ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat 4500 ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg 4560 ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata 4620 gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt 4680 tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat 4740 ttaacgcgaa ttttaacaaa atattaacgc ttacaattta ggtggcactt ttcggggaaa 4800 tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat 4860 gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagtattca 4920 acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca 4980 cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac gagtgggtta 5040 catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg aagaacgttt 5100 tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc gtattgacgc 5160 cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg ttgagtactc 5220 accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat gcagtgctgc 5280 cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg gaggaccgaa 5340 ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg atcgttggga 5400 accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc ctgtagcaat 5460 ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt cccggcaaca 5520 attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct cggcccttcc 5580 ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc gcggtatcat 5640 tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca cgacggggag 5700 tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct cactgattaa 5760 gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca 5820 tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc 5880 ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc 5940 ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc 6000 agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt 6060 cagcagagcg cagataccaa atactgttct tctagtgtag ccgtagttag gccaccactt 6120 caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc 6180 tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa 6240 ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac 6300 ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg 6360 gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga 6420 gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact 6480 tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa 6540 cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc 6600 gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg 6660 ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat 6720 acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc acgacaggtt 6780 tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc tcactcatta 6840 ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa ttgtgagcgg 6900 ataacaattt cacacaggaa acagctatga ccatgattac gccaagcgcg caattaaccc 6960 tcactaaagg gaacaaaagc tggagctgca agcttaatgt agtcttatgc aatactcttg 7020 tagtcttgca acatggtaac gatgagttag caacatgcct tacaaggaga gaaaaagcac 7080 cgtgcatgcc gattggtgga agtaaggtgg tacgatcgtg ccttattagg aaggcaacag 7140 acgggtctga catggattgg acgaaccact gaattgccgc attgcagaga tattgtattt 7200 aagtgcctag ctcgatacat aaacgggtct ctctggttag accagatctg agcctgggag 7260 ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc ttgagtgctt 7320 caagtagtgt gtgcccgtct gttgtgtgac tctggtaact agagatccct cagacccttt 7380 tagtcagtgt ggaaaatctc tagcagtggc gcccgaacag ggacttgaaa gcgaaaggga 7440 aaccagagga gctctctcga cgcaggactc ggcttgctga agcgcgcacg gcaagaggcg 7500 aggggcggcg actggtgagt acgccaaaaa ttttgactag cggaggctag aaggagagag 7560 atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgcgatgg gaaaaaattc 7620 ggttaaggcc agggggaaag aaaaaatata aattaaaaca tatagtatgg gcaagcaggg 7680 agctagaacg attcgcagtt aatcctggcc tgttagaaac atcagaaggc tgtagacaaa 7740 tactgggaca gctacaacca tcccttcaga caggatcaga agaacttaga tcattatata 7800 atacagtagc aaccctctat tgtgtgcatc aaaggataga gataaaagac accaaggaag 7860 ctttagacaa gatagaggaa gagcaaaaca aaagtaagac caccgcacag caagcggccg 7920 ctgatcttca gacctggagg aggagatatg agggacaatt ggagaagtga attatataaa 7980 tataaagtag taaaaattga accattagga gtagcaccca ccaaggcaaa gagaagagtg 8040 gtgcagagag aaaaaagagc agtgggaata ggagctttgt tccttgggtt cttgggagca 8100 gcaggaagca ctatgggcgc agcgtcaatg acgctgacgg tacaggccag acaattattg 8160 tctggtatag tgcagcagca gaacaatttg ctgagggcta ttgaggcgca acagcatctg 8220 ttgcaactca cagtctgggg catcaagcag ctccaggcaa gaatcctggc tgtggaaaga 8280 tacctaaagg atcaacagct cctggggatt tggggttgct ctggaaaact catttgcacc 8340 actgctgtgc cttggaatgc tagttggagt aataaatctc tggaacagat ttggaatcac 8400 acgacctgga tggagtggga cagagaaatt aacaattaca caagcttaat acactcctta 8460 attgaagaat cgcaaaacca gcaagaaaag aatgaacaag aattattgga attagataaa 8520 tgggcaagtt tgtggaattg gtttaacata acaaattggc tgtggtatat aaaattattc 8580 ataatgatag taggaggctt ggtaggttta agaatagttt ttgctgtact ttctatagtg 8640 aatagagtta ggcagggata ttcaccatta tcgtttcaga cccacctccc aaccccgagg 8700 ggacccttgc gccttttcca aggcagccct gggtttgcgc agggacgcgg ctgctctggg 8760 cgtggttccg ggaaacgcag cggcgccgac cctgggtctc gcacattctt cacgtccgtt 8820 cgcagcgtca cccggatctt cgccgctacc cttgtgggcc ccccggcgac gcttcctgct 8880 ccgcccctaa gtcgggaagg ttccttgcgg ttcgcggcgt gccggacgtg acaaacggaa 8940 gccgcacgtc tcactagtac cctcgcagac ggacagcgcc agggagcaat ggcagcgcgc 9000 cgaccgcgat gggctgtggc caatagcggc tgctcagcag ggcgcgccga gagcagcggc 9060 cgggaagggg cggtgcggga ggcggggtgt ggggcggtag tgtgggccct gttcctgccc 9120 gcgcggtgtt ccgcattctg caagcctccg gagcgcacgt cggcagtcgg ctccctcgtt 9180 gaccgaatca ccgacctctc tccccagggg gtacccagct gtctagagaa ttctagatct 9240 tgagacaaat ggcagtattc atccacaatt ttaaaagaaa aggggggatt ggggggtaca 9300 gtgcagggga aagaatagta gacataatag caacagacat acaaactaaa gaattacaaa 9360 aacaaattac aaaaattcaa aattttcggg tttattacag ggacagcaga gatccacttt 9420 ggcgccggct cgaggggg 9438 <210> 77 <211> 259 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 77 Met Ala Gln Leu Lys Lys Lys Leu Gln Ala Asn Lys Lys Glu Leu Ala 1 5 10 15 Gln Leu Lys Trp Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln Gly 20 25 30 Gly Gly Gly Ser Gly Ser Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu 35 40 45 Gly Lys Gln Asn Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe 50 55 60 Ala Leu Lys Asn Gly Phe Ile Ala Ser Asn Cys Val Thr Lys Gly Gly 65 70 75 80 Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly 85 90 95 Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile Pro Asp Tyr Tyr Lys 100 105 110 Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu 115 120 125 Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr Ser Leu Glu Asp Gly 130 135 140 Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Pro Asp 145 150 155 160 Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Thr Glu 165 170 175 Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly Asp Ile Lys Met Ala 180 185 190 Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu Ala Asp Phe Lys Thr Thr 195 200 205 Tyr Lys Ala Lys Lys Pro Val Gln Met Pro Gly Ala Tyr Asn Val Asp 210 215 220 Arg Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Val Val Glu 225 230 235 240 Gln Tyr Glu Arg Ser Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu 245 250 255 Leu Tyr Lys <210> 78 <211> 9219 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 78 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggtgag caagggcgag 660 gcagtgatca aggagttcat gcggttcaag gtgcacatgg agggctccat gaacggccac 720 gagttcgaga tcgagggcga gggcgagggc cgcccctacg agggcaccca gaccgccaag 780 ctgaaggtga ccaagtgcct ttcatacgag accgagatcc tgactgtcga gtacggattg 840 cttcctatcg gcaaaatcgt ggagaagagg attgaatgta ccgtctattc agtcgataat 900 aatgggaaca tctacacaca gcccgtggct caatggcacg acagaggaga gcaggaagtt 960 tttgaatact gtctcgagga cggatccctc atccgcgcta ctaaagatca taagtttatg 1020 accgtggacg gccagatgct gccaattgac gaaatttttg aacgagagct ggatctgatg 1080 agagtcgaca accttccaaa cggtggaggg gggtcaggct ctgcgcagct ggaaaaggag 1140 cttcaagccc tcgaaaaaaa gttggcccag ctcgagtggg agaaccaggc tctggagaaa 1200 gaactggccc agtgattaat taagaattcg acccagcttt cttgtacaaa gtggttggta 1260 agcctatccc taaccctctc ctcggtctcg attctacgta gtaatgagct agcagtctcg 1320 aggttaacga attccgcccc ccccctaacg ttactggccg aagccgcttg gaataaggcc 1380 ggtgtgcgct tgtctatatg ttattttcca ccatattgcc gtcttttggc aatgtgaggg 1440 cccggaaacc tggccctgtc ttcttgacga gcattcctag gggtctttcc cctctcgcca 1500 aaggaatgca aggtctgttg aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa 1560 gacaaacaac gtctgtagcg accctttgca ggcagcggaa ccccccacct ggcgacaggt 1620 gcccctgcgg ccaaaagcca cgtgtataag atacacctgc aaaggcggca caaccccagt 1680 gccacgttgt gagttggata gttgtggaaa gagtcaaatg gctctcctca agcgtattca 1740 acaaggggct gaaggatgcc cagaaggtac cccattgtat gggatctgat ctggggcctc 1800 ggtgcacatg ctttacatgt gtttagtcga ggttaaaaaa acgtctaggc cccccgaacc 1860 acggggacgt ggttttcctt tgaaaaacac gataatacca tggccatgag cgagctgatt 1920 aaggagaaca tgcacatgaa gctgtacatg gagggcaccg tggacaacca tcacttcaag 1980 tgcacatccg agggcgaagg caagccctac gagggcaccc agaccatgag aatcaaggtg 2040 gtcgagggcg gccctctccc cttcgccttc gacatcctgg ctactagctt cctctacggc 2100 agcaagacct tcatcaacca cacccagggc atccccgact tcttcaagca gtccttccct 2160 gagggcttca catgggagag agtcaccaca tacgaagacg ggggcgtgct gaccgctacc 2220 caggacacca gcctccagga cggctgcctc atctacaacg tcaagatcag aggggtgaac 2280 ttcacatcca acggccctgt gatgcagaag aaaacactcg gctgggaggc cttcaccgag 2340 acgctgtacc ccgctgacgg cggcctggaa ggcagaaacg acatggccct gaagctcgtg 2400 ggcgggagcc atctgatcgc aaacatcaag accacatata gatccaagaa acccgctaag 2460 aacctcaaga tgcctggcgt ctactatgtg gactacagac tggaaagaat caaggaggcc 2520 aacaacgaga cctacgtcga gcagcacgag gtggcagtgg ccagatactg cgacctccct 2580 agcaaactgg ggcacaagct taattaacac cggtggcgcg ttaagtcgac aatcaacctc 2640 tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct ccttttacgc 2700 tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt atggctttca 2760 ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg tggcccgttg 2820 tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact ggttggggca 2880 ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct attgccacgg 2940 cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg ttgggcactg 3000 acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc gcctgtgttg 3060 ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc aatccagcgg 3120 accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc 3180 ctcagacgag tcggatctcc ctttgggccg cctccccgcg tcgactttaa gaccaatgac 3240 ttacaaggca gctgtagatc ttagccactt tttaaaagaa aaggggggac tggaagggct 3300 aattcactcc caacgaagac aagatctgct ttttgcttgt actgggtctc tctggttaga 3360 ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata 3420 aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta 3480 gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagtacgt atagtagttc 3540 atgtcatctt attattcagt atttataact tgcaaagaaa tgaatatcag agagtgagag 3600 gaacttgttt attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac 3660 aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc 3720 ttatcatgtc tggctctagc tatcccgccc ctaactccgc ccatcccgcc cctaactccg 3780 cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc 3840 gaggccgcct cggcctctga gctattccag aagtagtgag gaggcttttt tggaggccta 3900 gggacgtacc caattcgccc tatagtgagt cgtattacgc gcgctcactg gccgtcgttt 3960 tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc 4020 cccctttcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt 4080 tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 4140 tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 4200 ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 4260 ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 4320 agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 4380 tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 4440 tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 4500 atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 4560 aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca 4620 ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa 4680 aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt 4740 ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca 4800 gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag 4860 ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc 4920 ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca 4980 gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt 5040 aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct 5100 gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt 5160 aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga 5220 caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact 5280 tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc 5340 acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga 5400 gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt 5460 agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga 5520 gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact 5580 ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga 5640 taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt 5700 agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca 5760 aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct 5820 ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc ttctagtgta 5880 gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct 5940 aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc 6000 aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca 6060 gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga 6120 aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg 6180 aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt 6240 cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag 6300 cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt 6360 tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt 6420 tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga 6480 ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta 6540 atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa 6600 tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcgtat 6660 gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta 6720 cgccaagcgc gcaattaacc ctcactaaag ggaacaaaag ctggagctgc aagcttaatg 6780 tagtcttatg caatactctt gtagtcttgc aacatggtaa cgatgagtta gcaacatgcc 6840 ttacaaggag agaaaaagca ccgtgcatgc cgattggtgg aagtaaggtg gtacgatcgt 6900 gccttattag gaaggcaaca gacgggtctg acatggattg gacgaaccac tgaattgccg 6960 cattgcagag atattgtatt taagtgccta gctcgataca taaacgggtc tctctggtta 7020 gaccagatct gagcctggga gctctctggc taactaggga acccactgct taagcctcaa 7080 taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac 7140 tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg cgcccgaaca 7200 gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact cggcttgctg 7260 aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa attttgacta 7320 gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg gggagaatta 7380 gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat aaattaaaac 7440 atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc ctgttagaaa 7500 catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag acaggatcag 7560 aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat caaaggatag 7620 agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac aaaagtaaga 7680 ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat gagggacaat 7740 tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc 7800 accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg 7860 ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg 7920 gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct 7980 attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca 8040 agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc 8100 tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct 8160 ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac 8220 acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa gaatgaacaa 8280 gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat aacaaattgg 8340 ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt aagaatagtt 8400 tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt atcgtttcag 8460 acccacctcc caaccccgag gggacccttg cgccttttcc aaggcagccc tgggtttgcg 8520 cagggacgcg gctgctctgg gcgtggttcc gggaaacgca gcggcgccga ccctgggtct 8580 cgcacattct tcacgtccgt tcgcagcgtc acccggatct tcgccgctac ccttgtgggc 8640 cccccggcga cgcttcctgc tccgccccta agtcgggaag gttccttgcg gttcgcggcg 8700 tgccggacgt gacaaacgga agccgcacgt ctcactagta ccctcgcaga cggacagcgc 8760 cagggagcaa tggcagcgcg ccgaccgcga tgggctgtgg ccaatagcgg ctgctcagca 8820 gggcgcgccg agagcagcgg ccgggaaggg gcggtgcggg aggcggggtg tggggcggta 8880 gtgtgggccc tgttcctgcc cgcgcggtgt tccgcattct gcaagcctcc ggagcgcacg 8940 tcggcagtcg gctccctcgt tgaccgaatc accgacctct ctccccaggg ggtacccagc 9000 tgtctagaga attctagatc ttgagacaaa tggcagtatt catccacaat tttaaaagaa 9060 aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca 9120 tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca 9180 gggacagcag agatccactt tggcgccggc tcgaggggg 9219 <210> 79 <211> 190 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 79 Met Val Ser Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys 1 5 10 15 Val His Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 20 25 30 Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 35 40 45 Val Thr Lys Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr 50 55 60 Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr 65 70 75 80 Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala 85 90 95 Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu 100 105 110 Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val 115 120 125 Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp 130 135 140 Leu Met Arg Val Asp Asn Leu Pro Asn Gly Gly Gly Gly Ser Gly Ser 145 150 155 160 Ala Gln Leu Glu Lys Glu Leu Gln Ala Leu Glu Lys Lys Leu Ala Gln 165 170 175 Leu Glu Trp Glu Asn Gln Ala Leu Glu Lys Glu Leu Ala Gln 180 185 190 <210> 80 <211> 9429 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 80 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggctca actgaagaag 660 aaactccagg ccaataagaa agaactggca cagctgaagt ggaagctgca ggcactgaaa 720 aagaagctgg cacagggcgg aggaggctca ggcagtatga ttaagatcgc tacgcggaag 780 tacctgggga aacagaacgt ctacgacata ggtgtggagc gcgatcacaa ctttgctctg 840 aaaaatggat ttatcgccag caactgcggt ggccccctgc ccttctcctg ggacatcctg 900 tcccctcagt tcatgtacgg ctccagggcc ttcaccaagc accccgccga catccccgac 960 tactataagc agtccttccc cgagggcttc aagtgggagc gcgtgatgaa cttcgaggac 1020 ggcggcgccg tgaccgtgac ccaggacacc tccctggagg acggcaccct gatctacaag 1080 gtgaagctcc gcggcaccaa cttccctcct gacggccccg taatgcagaa gaagacaatg 1140 ggctgggaag cgtccaccga gcggttgtac cccgaggacg gcgtgctgaa gggcgacatt 1200 aagatggccc tgcgcctgaa ggacggcggc cgctacctgg cggacttcaa gaccacctac 1260 aaggccaaga agcccgtgca gatgcccggc gcctacaacg tcgaccgcaa gttggacatc 1320 acctcccaca acgaggacta caccgtggtg gaacagtacg aacgctccga gggccgccac 1380 tccaccggcg gcatggacga gctgtacaag tgattaatta agaattcgac ccagctttct 1440 tgtacaaagt ggttggtaag cctatcccta accctctcct cggtctcgat tctacgtagt 1500 aatgagctag cagtctcgag gttaacgaat tccgcccccc ccctaacgtt actggccgaa 1560 gccgcttgga ataaggccgg tgtgcgcttg tctatatgtt attttccacc atattgccgt 1620 cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg 1680 gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc 1740 ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc 1800 ccccacctgg cgacaggtgc ccctgcggcc aaaagccacg tgtataagat acacctgcaa 1860 aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc 1920 tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg 1980 gatctgatct ggggcctcgg tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaaac 2040 gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga taataccatg 2100 gtgagcaagg gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc 2160 gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc 2220 aagctgaccc tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc 2280 gtgaccaccc tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag 2340 cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc 2400 aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg 2460 aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag 2520 ctggagtaca actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc 2580 atcaaggtga acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac 2640 cactaccagc agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac 2700 ctgagcaccc agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg 2760 ctggagttcg tgaccgccgc cgggatcact ctcggcatgg acgagctgta caagtaacac 2820 cggtggcgcg ttaagtcgac aatcaacctc tggattacaa aatttgtgaa agattgactg 2880 gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt 2940 atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc 3000 tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt 3060 ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga 3120 ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct 3180 gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat 3240 cgtcctttcc ttggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct 3300 gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc 3360 tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg 3420 cctccccgcg tcgactttaa gaccaatgac ttacaaggca gctgtagatc ttagccactt 3480 tttaaaagaa aaggggggac tggaagggct aattcactcc caacgaagac aagatctgct 3540 ttttgcttgt actgggtctc tctggttaga ccagatctga gcctgggagc tctctggcta 3600 actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc aagtagtgtg 3660 tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt agtcagtgtg 3720 gaaaatctct agcagtacgt atagtagttc atgtcatctt attattcagt atttataact 3780 tgcaaagaaa tgaatatcag agagtgagag gaacttgttt attgcagctt ataatggtta 3840 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 3900 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggctctagc tatcccgccc 3960 ctaactccgc ccatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc 4020 tgactaattt tttttattta tgcagaggcc gaggccgcct cggcctctga gctattccag 4080 aagtagtgag gaggcttttt tggaggccta gggacgtacc caattcgccc tatagtgagt 4140 cgtattacgc gcgctcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg 4200 ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag 4260 aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgggacgcgc 4320 cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac 4380 ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg 4440 ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt 4500 tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc 4560 cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct 4620 tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga 4680 ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga 4740 attttaacaa aatattaacg cttacaattt aggtggcact tttcggggaa atgtgcgcgg 4800 aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata 4860 accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg 4920 tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac 4980 gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact 5040 ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat 5100 gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga 5160 gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac 5220 agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat 5280 gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac 5340 cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct 5400 gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac 5460 gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga 5520 ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg 5580 gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact 5640 ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac 5700 tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta 5760 actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt 5820 taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga 5880 gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc 5940 tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt 6000 ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc 6060 gcagatacca aatactgttc ttctagtgta gccgtagtta ggccaccact tcaagaactc 6120 tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg 6180 cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg 6240 gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga 6300 actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc 6360 ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg 6420 gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg 6480 atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt 6540 tttacggttc ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc 6600 tgattctgtg gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg 6660 aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc 6720 gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt ttcccgactg 6780 gaaagcgggc agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca 6840 ggctttacac tttatgcttc cggctcgtat gttgtgtgga attgtgagcg gataacaatt 6900 tcacacagga aacagctatg accatgatta cgccaagcgc gcaattaacc ctcactaaag 6960 ggaacaaaag ctggagctgc aagcttaatg tagtcttatg caatactctt gtagtcttgc 7020 aacatggtaa cgatgagtta gcaacatgcc ttacaaggag agaaaaagca ccgtgcatgc 7080 cgattggtgg aagtaaggtg gtacgatcgt gccttattag gaaggcaaca gacgggtctg 7140 acatggattg gacgaaccac tgaattgccg cattgcagag atattgtatt taagtgccta 7200 gctcgataca taaacgggtc tctctggtta gaccagatct gagcctggga gctctctggc 7260 taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg 7320 tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg 7380 tggaaaatct ctagcagtgg cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg 7440 agctctctcg acgcaggact cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc 7500 gactggtgag tacgccaaaa attttgacta gcggaggcta gaaggagaga gatgggtgcg 7560 agagcgtcag tattaagcgg gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc 7620 cagggggaaa gaaaaaatat aaattaaaac atatagtatg ggcaagcagg gagctagaac 7680 gattcgcagt taatcctggc ctgttagaaa catcagaagg ctgtagacaa atactgggac 7740 agctacaacc atcccttcag acaggatcag aagaacttag atcattatat aatacagtag 7800 caaccctcta ttgtgtgcat caaaggatag agataaaaga caccaaggaa gctttagaca 7860 agatagagga agagcaaaac aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc 7920 agacctggag gaggagatat gagggacaat tggagaagtg aattatataa atataaagta 7980 gtaaaaattg aaccattagg agtagcaccc accaaggcaa agagaagagt ggtgcagaga 8040 gaaaaaagag cagtgggaat aggagctttg ttccttgggt tcttgggagc agcaggaagc 8100 actatgggcg cagcgtcaat gacgctgacg gtacaggcca gacaattatt gtctggtata 8160 gtgcagcagc agaacaattt gctgagggct attgaggcgc aacagcatct gttgcaactc 8220 acagtctggg gcatcaagca gctccaggca agaatcctgg ctgtggaaag atacctaaag 8280 gatcaacagc tcctggggat ttggggttgc tctggaaaac tcatttgcac cactgctgtg 8340 ccttggaatg ctagttggag taataaatct ctggaacaga tttggaatca cacgacctgg 8400 atggagtggg acagagaaat taacaattac acaagcttaa tacactcctt aattgaagaa 8460 tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg aattagataa atgggcaagt 8520 ttgtggaatt ggtttaacat aacaaattgg ctgtggtata taaaattatt cataatgata 8580 gtaggaggct tggtaggttt aagaatagtt tttgctgtac tttctatagt gaatagagtt 8640 aggcagggat attcaccatt atcgtttcag acccacctcc caaccccgag gggacccttg 8700 cgccttttcc aaggcagccc tgggtttgcg cagggacgcg gctgctctgg gcgtggttcc 8760 gggaaacgca gcggcgccga ccctgggtct cgcacattct tcacgtccgt tcgcagcgtc 8820 acccggatct tcgccgctac ccttgtgggc cccccggcga cgcttcctgc tccgccccta 8880 agtcgggaag gttccttgcg gttcgcggcg tgccggacgt gacaaacgga agccgcacgt 8940 ctcactagta ccctcgcaga cggacagcgc cagggagcaa tggcagcgcg ccgaccgcga 9000 tgggctgtgg ccaatagcgg ctgctcagca gggcgcgccg agagcagcgg ccgggaaggg 9060 gcggtgcggg aggcggggtg tggggcggta gtgtgggccc tgttcctgcc cgcgcggtgt 9120 tccgcattct gcaagcctcc ggagcgcacg tcggcagtcg gctccctcgt tgaccgaatc 9180 accgacctct ctccccaggg ggtacccagc tgtctagaga attctagatc ttgagacaaa 9240 tggcagtatt catccacaat tttaaaagaa aaggggggat tggggggtac agtgcagggg 9300 aaagaatagt agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta 9360 caaaaattca aaattttcgg gtttattaca gggacagcag agatccactt tggcgccggc 9420 tcgaggggg 9429 <210> 81 <211> 256 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 81 Met Ala Gln Leu Lys Lys Lys Leu Gln Ala Asn Lys Lys Glu Leu Ala 1 5 10 15 Gln Leu Lys Trp Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln Gly 20 25 30 Gly Gly Gly Ser Gly Ser Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu 35 40 45 Gly Lys Gln Asn Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe 50 55 60 Ala Leu Lys Asn Gly Phe Ile Ala Ser Asn Cys Gly Gly Pro Leu Pro 65 70 75 80 Phe Ser Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Arg Ala 85 90 95 Phe Thr Lys His Pro Ala Asp Ile Pro Asp Tyr Tyr Lys Gln Ser Phe 100 105 110 Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly 115 120 125 Ala Val Thr Val Thr Gln Asp Thr Ser Leu Glu Asp Gly Thr Leu Ile 130 135 140 Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Pro Asp Gly Pro Val 145 150 155 160 Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr 165 170 175 Pro Glu Asp Gly Val Leu Lys Gly Asp Ile Lys Met Ala Leu Arg Leu 180 185 190 Lys Asp Gly Gly Arg Tyr Leu Ala Asp Phe Lys Thr Thr Tyr Lys Ala 195 200 205 Lys Lys Pro Val Gln Met Pro Gly Ala Tyr Asn Val Asp Arg Lys Leu 210 215 220 Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Val Val Glu Gln Tyr Glu 225 230 235 240 Arg Ser Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 245 250 255 <210> 82 <211> 9291 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 82 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggtgag caagggcgag 660 gcagtgatca aggagttcat gcggttcaag gtgcacatgg agggctccat gaacggccac 720 gagttcgaga tcgagggcga gggcgagggc cgcccctacg agggcaccca gaccgccaag 780 ctgaaggtga ccaagggtgg ccccctgccc ttctcctggg acatcctgtc ccctcagttc 840 atgtacggct ccagggcctt caccaagtgc ctttcatacg agaccgagat cctgactgtc 900 gagtacggat tgcttcctat cggcaaaatc gtggagaaga ggattgaatg taccgtctat 960 tcagtcgata ataatgggaa catctacaca cagcccgtgg ctcaatggca cgacagagga 1020 gagcaggaag tttttgaata ctgtctcgag gacggatccc tcatccgcgc tactaaagat 1080 cataagttta tgaccgtgga cggccagatg ctgccaattg acgaaatttt tgaacgagag 1140 ctggatctga tgagagtcga caaccttcca aacggtggag gggggtcagg ctctgcgcag 1200 ctggaaaagg agcttcaagc cctcgaaaaa aagttggccc agctcgagtg ggagaaccag 1260 gctctggaga aagaactggc ccagtgatta attaagaatt cgacccagct ttcttgtaca 1320 aagtggttgg taagcctatc cctaaccctc tcctcggtct cgattctacg tagtaatgag 1380 ctagcagtct cgaggttaac gaattccgcc ccccccctaa cgttactggc cgaagccgct 1440 tggaataagg ccggtgtgcg cttgtctata tgttattttc caccatattg ccgtcttttg 1500 gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct aggggtcttt 1560 cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg 1620 aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg aaccccccac 1680 ctggcgacag gtgcccctgc ggccaaaagc cacgtgtata agatacacct gcaaaggcgg 1740 cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa tggctctcct 1800 caagcgtatt caacaagggg ctgaaggatg cccagaaggt accccattgt atgggatctg 1860 atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa aaacgtctag 1920 gccccccgaa ccacggggac gtggttttcc tttgaaaaac acgataatac catggccatg 1980 agcgagctga ttaaggagaa catgcacatg aagctgtaca tggagggcac cgtggacaac 2040 catcacttca agtgcacatc cgagggcgaa ggcaagccct acgagggcac ccagaccatg 2100 agaatcaagg tggtcgaggg cggccctctc cccttcgcct tcgacatcct ggctactagc 2160 ttcctctacg gcagcaagac cttcatcaac cacacccagg gcatccccga cttcttcaag 2220 cagtccttcc ctgagggctt cacatgggag agagtcacca catacgaaga cgggggcgtg 2280 ctgaccgcta cccaggacac cagcctccag gacggctgcc tcatctacaa cgtcaagatc 2340 agaggggtga acttcacatc caacggccct gtgatgcaga agaaaacact cggctgggag 2400 gccttcaccg agacgctgta ccccgctgac ggcggcctgg aaggcagaaa cgacatggcc 2460 ctgaagctcg tgggcgggag ccatctgatc gcaaacatca agaccacata tagatccaag 2520 aaacccgcta agaacctcaa gatgcctggc gtctactatg tggactacag actggaaaga 2580 atcaaggagg ccaacaacga gacctacgtc gagcagcacg aggtggcagt ggccagatac 2640 tgcgacctcc ctagcaaact ggggcacaag cttaattaac accggtggcg cgttaagtcg 2700 acaatcaacc tctggattac aaaatttgtg aaagattgac tggtattctt aactatgttg 2760 ctccttttac gctatgtgga tacgctgctt taatgccttt gtatcatgct attgcttccc 2820 gtatggcttt cattttctcc tccttgtata aatcctggtt gctgtctctt tatgaggagt 2880 tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac gcaaccccca 2940 ctggttgggg cattgccacc acctgtcagc tcctttccgg gactttcgct ttccccctcc 3000 ctattgccac ggcggaactc atcgccgcct gccttgcccg ctgctggaca ggggctcggc 3060 tgttgggcac tgacaattcc gtggtgttgt cggggaaatc atcgtccttt ccttggctgc 3120 tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc ccttcggccc 3180 tcaatccagc ggaccttcct tcccgcggcc tgctgccggc tctgcggcct cttccgcgtc 3240 ttcgccttcg ccctcagacg agtcggatct ccctttgggc cgcctccccg cgtcgacttt 3300 aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag aaaagggggg 3360 actggaaggg ctaattcact cccaacgaag acaagatctg ctttttgctt gtactgggtc 3420 tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct 3480 taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga 3540 ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtac 3600 gtatagtagt tcatgtcatc ttattattca gtatttataa cttgcaaaga aatgaatatc 3660 agagagtgag aggaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat 3720 cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact 3780 catcaatgta tcttatcatg tctggctcta gctatcccgc ccctaactcc gcccatcccg 3840 cccctaactc cgcccagttc cgcccattct ccgccccatg gctgactaat tttttttatt 3900 tatgcagagg ccgaggccgc ctcggcctct gagctattcc agaagtagtg aggaggcttt 3960 tttggaggcc tagggacgta cccaattcgc cctatagtga gtcgtattac gcgcgctcac 4020 tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg cgttacccaa cttaatcgcc 4080 ttgcagcaca tccccctttc gccagctggc gtaatagcga agaggcccgc accgatcgcc 4140 cttcccaaca gttgcgcagc ctgaatggcg aatgggacgc gccctgtagc ggcgcattaa 4200 gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc gccctagcgc 4260 ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag 4320 ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac ctcgacccca 4380 aaaaacttga ttagggtgat ggttcacgta gtgggccatc gccctgatag acggtttttc 4440 gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa actggaacaa 4500 cactcaaccc tatctcggtc tattcttttg atttataagg gattttgccg atttcggcct 4560 attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattttaac aaaatattaa 4620 cgcttacaat ttaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt 4680 tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca 4740 ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt 4800 ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga 4860 tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa 4920 gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct 4980 gctatgtggc gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat 5040 acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga 5100 tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc 5160 caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat 5220 gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa 5280 cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac 5340 tggcgaacta cttactctag cttcccggca acaattaata gactggatgg aggcggataa 5400 agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc 5460 tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc 5520 ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag 5580 acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag accaagttta 5640 ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa 5700 gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc 5760 gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat 5820 ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga 5880 gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt 5940 tcttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata 6000 cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac 6060 cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg 6120 ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg 6180 tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag 6240 cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct 6300 ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc 6360 aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt 6420 ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg 6480 tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga 6540 gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg 6600 gccgattcat taatgcagct ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg 6660 caacgcaatt aatgtgagtt agctcactca ttaggcaccc caggctttac actttatgct 6720 tccggctcgt atgttgtgtg gaattgtgag cggataacaa tttcacacag gaaacagcta 6780 tgaccatgat tacgccaagc gcgcaattaa ccctcactaa agggaacaaa agctggagct 6840 gcaagcttaa tgtagtctta tgcaatactc ttgtagtctt gcaacatggt aacgatgagt 6900 tagcaacatg ccttacaagg agagaaaaag caccgtgcat gccgattggt ggaagtaagg 6960 tggtacgatc gtgccttatt aggaaggcaa cagacgggtc tgacatggat tggacgaacc 7020 actgaattgc cgcattgcag agatattgta tttaagtgcc tagctcgata cataaacggg 7080 tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg 7140 cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt 7200 gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt 7260 ggcgcccgaa cagggacttg aaagcgaaag ggaaaccaga ggagctctct cgacgcagga 7320 ctcggcttgc tgaagcgcgc acggcaagag gcgaggggcg gcgactggtg agtacgccaa 7380 aaattttgac tagcggaggc tagaaggaga gagatgggtg cgagagcgtc agtattaagc 7440 gggggagaat tagatcgcga tgggaaaaaa ttcggttaag gccaggggga aagaaaaaat 7500 ataaattaaa acatatagta tgggcaagca gggagctaga acgattcgca gttaatcctg 7560 gcctgttaga aacatcagaa ggctgtagac aaatactggg acagctacaa ccatcccttc 7620 agacaggatc agaagaactt agatcattat ataatacagt agcaaccctc tattgtgtgc 7680 atcaaaggat agagataaaa gacaccaagg aagctttaga caagatagag gaagagcaaa 7740 acaaaagtaa gaccaccgca cagcaagcgg ccgctgatct tcagacctgg aggaggagat 7800 atgagggaca attggagaag tgaattatat aaatataaag tagtaaaaat tgaaccatta 7860 ggagtagcac ccaccaaggc aaagagaaga gtggtgcaga gagaaaaaag agcagtggga 7920 ataggagctt tgttccttgg gttcttggga gcagcaggaa gcactatggg cgcagcgtca 7980 atgacgctga cggtacaggc cagacaatta ttgtctggta tagtgcagca gcagaacaat 8040 ttgctgaggg ctattgaggc gcaacagcat ctgttgcaac tcacagtctg gggcatcaag 8100 cagctccagg caagaatcct ggctgtggaa agatacctaa aggatcaaca gctcctgggg 8160 atttggggtt gctctggaaa actcatttgc accactgctg tgccttggaa tgctagttgg 8220 agtaataaat ctctggaaca gatttggaat cacacgacct ggatggagtg ggacagagaa 8280 attaacaatt acacaagctt aatacactcc ttaattgaag aatcgcaaaa ccagcaagaa 8340 aagaatgaac aagaattatt ggaattagat aaatgggcaa gtttgtggaa ttggtttaac 8400 ataacaaatt ggctgtggta tataaaatta ttcataatga tagtaggagg cttggtaggt 8460 ttaagaatag tttttgctgt actttctata gtgaatagag ttaggcaggg atattcacca 8520 ttatcgtttc agacccacct cccaaccccg aggggaccct tgcgcctttt ccaaggcagc 8580 cctgggtttg cgcagggacg cggctgctct gggcgtggtt ccgggaaacg cagcggcgcc 8640 gaccctgggt ctcgcacatt cttcacgtcc gttcgcagcg tcacccggat cttcgccgct 8700 acccttgtgg gccccccggc gacgcttcct gctccgcccc taagtcggga aggttccttg 8760 cggttcgcgg cgtgccggac gtgacaaacg gaagccgcac gtctcactag taccctcgca 8820 gacggacagc gccagggagc aatggcagcg cgccgaccgc gatgggctgt ggccaatagc 8880 ggctgctcag cagggcgcgc cgagagcagc ggccgggaag gggcggtgcg ggaggcgggg 8940 tgtggggcgg tagtgtgggc cctgttcctg cccgcgcggt gttccgcatt ctgcaagcct 9000 ccggagcgca cgtcggcagt cggctccctc gttgaccgaa tcaccgacct ctctccccag 9060 ggggtaccca gctgtctaga gaattctaga tcttgagaca aatggcagta ttcatccaca 9120 attttaaaag aaaagggggg attggggggt acagtgcagg ggaaagaata gtagacataa 9180 tagcaacaga catacaaact aaagaattac aaaaacaaat tacaaaaatt caaaattttc 9240 gggtttatta cagggacagc agagatccac tttggcgccg gctcgagggg g 9291 <210> 83 <211> 214 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 83 Met Val Ser Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys 1 5 10 15 Val His Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 20 25 30 Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 35 40 45 Val Thr Lys Gly Gly Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro 50 55 60 Gln Phe Met Tyr Gly Ser Arg Ala Phe Thr Lys Cys Leu Ser Tyr Glu 65 70 75 80 Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile 85 90 95 Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly 100 105 110 Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln 115 120 125 Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr 130 135 140 Lys Asp His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp 145 150 155 160 Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro 165 170 175 Asn Gly Gly Gly Gly Ser Gly Ser Ala Gln Leu Glu Lys Glu Leu Gln 180 185 190 Ala Leu Glu Lys Lys Leu Ala Gln Leu Glu Trp Glu Asn Gln Ala Leu 195 200 205 Glu Lys Glu Leu Ala Gln 210 <210> 84 <211> 9357 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 84 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggctca actgaagaag 660 aaactccagg ccaataagaa agaactggca cagctgaagt ggaagctgca ggcactgaaa 720 aagaagctgg cacagggcgg aggaggctca ggcagtatga ttaagatcgc tacgcggaag 780 tacctgggga aacagaacgt ctacgacata ggtgtggagc gcgatcacaa ctttgctctg 840 aaaaatggat ttatcgccag caactgccac cccgccgaca tccccgacta ctataagcag 900 tccttccccg agggcttcaa gtgggagcgc gtgatgaact tcgaggacgg cggcgccgtg 960 accgtgaccc aggacacctc cctggaggac ggcaccctga tctacaaggt gaagctccgc 1020 ggcaccaact tccctcctga cggccccgta atgcagaaga agacaatggg ctgggaagcg 1080 tccaccgagc ggttgtaccc cgaggacggc gtgctgaagg gcgacattaa gatggccctg 1140 cgcctgaagg acggcggccg ctacctggcg gacttcaaga ccacctacaa ggccaagaag 1200 cccgtgcaga tgcccggcgc ctacaacgtc gaccgcaagt tggacatcac ctcccacaac 1260 gaggactaca ccgtggtgga acagtacgaa cgctccgagg gccgccactc caccggcggc 1320 atggacgagc tgtacaagtg attaattaag aattcgaccc agctttcttg tacaaagtgg 1380 ttggtaagcc tatccctaac cctctcctcg gtctcgattc tacgtagtaa tgagctagca 1440 gtctcgaggt taacgaattc cgcccccccc ctaacgttac tggccgaagc cgcttggaat 1500 aaggccggtg tgcgcttgtc tatatgttat tttccaccat attgccgtct tttggcaatg 1560 tgagggcccg gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc 1620 tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt 1680 cttgaagaca aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg 1740 acaggtgccc ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac 1800 cccagtgcca cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg 1860 tattcaacaa ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg 1920 ggcctcggtg cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt ctaggccccc 1980 cgaaccacgg ggacgtggtt ttcctttgaa aaacacgata ataccatggt gagcaagggc 2040 gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga cgtaaacggc 2100 cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa gctgaccctg 2160 aagttcatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt gaccaccctg 2220 acctacggcg tgcagtgctt cagccgctac cccgaccaca tgaagcagca cgacttcttc 2280 aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa ggacgacggc 2340 aactacaaga cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa ccgcatcgag 2400 ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct ggagtacaac 2460 tacaacagcc acaacgtcta tatcatggcc gacaagcaga agaacggcat caaggtgaac 2520 ttcaagatcc gccacaacat cgaggacggc agcgtgcagc tcgccgacca ctaccagcag 2580 aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct gagcacccag 2640 tccgccctga gcaaagaccc caacgagaag cgcgatcaca tggtcctgct ggagttcgtg 2700 accgccgccg ggatcactct cggcatggac gagctgtaca agtaacaccg gtggcgcgtt 2760 aagtcgacaa tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact 2820 atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg 2880 cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg 2940 aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa 3000 cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc 3060 ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg 3120 ctcggctgtt gggcactgac aattccgtgg tgttgtcggg gaaatcatcg tcctttcctt 3180 ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt 3240 cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc 3300 cgcgtcttcg ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgcgtc 3360 gactttaaga ccaatgactt acaaggcagc tgtagatctt agccactttt taaaagaaaa 3420 ggggggactg gaagggctaa ttcactccca acgaagacaa gatctgcttt ttgcttgtac 3480 tgggtctctc tggttagacc agatctgagc ctgggagctc tctggctaac tagggaaccc 3540 actgcttaag cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg cccgtctgtt 3600 gtgtgactct ggtaactaga gatccctcag acccttttag tcagtgtgga aaatctctag 3660 cagtacgtat agtagttcat gtcatcttat tattcagtat ttataacttg caaagaaatg 3720 aatatcagag agtgagagga acttgtttat tgcagcttat aatggttaca aataaagcaa 3780 tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc 3840 caaactcatc aatgtatctt atcatgtctg gctctagcta tcccgcccct aactccgccc 3900 atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt 3960 tttatttatg cagaggccga ggccgcctcg gcctctgagc tattccagaa gtagtgagga 4020 ggcttttttg gaggcctagg gacgtaccca attcgcccta tagtgagtcg tattacgcgc 4080 gctcactggc cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta 4140 atcgccttgc agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg 4200 atcgcccttc ccaacagttg cgcagcctga atggcgaatg ggacgcgccc tgtagcggcg 4260 cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc 4320 tagcgcccgc tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc 4380 gtcaagctct aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg 4440 accccaaaaa acttgattag ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg 4500 tttttcgccc tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg 4560 gaacaacact caaccctatc tcggtctatt cttttgattt ataagggatt ttgccgattt 4620 cggcctattg gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa 4680 tattaacgct tacaatttag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg 4740 tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat 4800 gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat 4860 tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt 4920 aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag 4980 cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa 5040 agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg 5100 ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct 5160 tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac 5220 tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca 5280 caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat 5340 accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact 5400 attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc 5460 ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga 5520 taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg 5580 taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg 5640 aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca 5700 agtttactca tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta 5760 ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca 5820 ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg 5880 cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga 5940 tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa 6000 tactgttctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc 6060 tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg 6120 tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac 6180 ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct 6240 acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc 6300 ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg 6360 gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg 6420 ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct 6480 ggccttttgc tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga 6540 taaccgtatt accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg 6600 cagcgagtca gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc 6660 gcgttggccg attcattaat gcagctggca cgacaggttt cccgactgga aagcgggcag 6720 tgagcgcaac gcaattaatg tgagttagct cactcattag gcaccccagg ctttacactt 6780 tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc acacaggaaa 6840 cagctatgac catgattacg ccaagcgcgc aattaaccct cactaaaggg aacaaaagct 6900 ggagctgcaa gcttaatgta gtcttatgca atactcttgt agtcttgcaa catggtaacg 6960 atgagttagc aacatgcctt acaaggagag aaaaagcacc gtgcatgccg attggtggaa 7020 gtaaggtggt acgatcgtgc cttattagga aggcaacaga cgggtctgac atggattgga 7080 cgaaccactg aattgccgca ttgcagagat attgtattta agtgcctagc tcgatacata 7140 aacgggtctc tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac 7200 ccactgctta agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg 7260 ttgtgtgact ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct 7320 agcagtggcg cccgaacagg gacttgaaag cgaaagggaa accagaggag ctctctcgac 7380 gcaggactcg gcttgctgaa gcgcgcacgg caagaggcga ggggcggcga ctggtgagta 7440 cgccaaaaat tttgactagc ggaggctaga aggagagaga tgggtgcgag agcgtcagta 7500 ttaagcgggg gagaattaga tcgcgatggg aaaaaattcg gttaaggcca gggggaaaga 7560 aaaaatataa attaaaacat atagtatggg caagcaggga gctagaacga ttcgcagtta 7620 atcctggcct gttagaaaca tcagaaggct gtagacaaat actgggacag ctacaaccat 7680 cccttcagac aggatcagaa gaacttagat cattatataa tacagtagca accctctatt 7740 gtgtgcatca aaggatagag ataaaagaca ccaaggaagc tttagacaag atagaggaag 7800 agcaaaacaa aagtaagacc accgcacagc aagcggccgc tgatcttcag acctggagga 7860 ggagatatga gggacaattg gagaagtgaa ttatataaat ataaagtagt aaaaattgaa 7920 ccattaggag tagcacccac caaggcaaag agaagagtgg tgcagagaga aaaaagagca 7980 gtgggaatag gagctttgtt ccttgggttc ttgggagcag caggaagcac tatgggcgca 8040 gcgtcaatga cgctgacggt acaggccaga caattattgt ctggtatagt gcagcagcag 8100 aacaatttgc tgagggctat tgaggcgcaa cagcatctgt tgcaactcac agtctggggc 8160 atcaagcagc tccaggcaag aatcctggct gtggaaagat acctaaagga tcaacagctc 8220 ctggggattt ggggttgctc tggaaaactc atttgcacca ctgctgtgcc ttggaatgct 8280 agttggagta ataaatctct ggaacagatt tggaatcaca cgacctggat ggagtgggac 8340 agagaaatta acaattacac aagcttaata cactccttaa ttgaagaatc gcaaaaccag 8400 caagaaaaga atgaacaaga attattggaa ttagataaat gggcaagttt gtggaattgg 8460 tttaacataa caaattggct gtggtatata aaattattca taatgatagt aggaggcttg 8520 gtaggtttaa gaatagtttt tgctgtactt tctatagtga atagagttag gcagggatat 8580 tcaccattat cgtttcagac ccacctccca accccgaggg gacccttgcg ccttttccaa 8640 ggcagccctg ggtttgcgca gggacgcggc tgctctgggc gtggttccgg gaaacgcagc 8700 ggcgccgacc ctgggtctcg cacattcttc acgtccgttc gcagcgtcac ccggatcttc 8760 gccgctaccc ttgtgggccc cccggcgacg cttcctgctc cgcccctaag tcgggaaggt 8820 tccttgcggt tcgcggcgtg ccggacgtga caaacggaag ccgcacgtct cactagtacc 8880 ctcgcagacg gacagcgcca gggagcaatg gcagcgcgcc gaccgcgatg ggctgtggcc 8940 aatagcggct gctcagcagg gcgcgccgag agcagcggcc gggaaggggc ggtgcgggag 9000 gcggggtgtg gggcggtagt gtgggccctg ttcctgcccg cgcggtgttc cgcattctgc 9060 aagcctccgg agcgcacgtc ggcagtcggc tccctcgttg accgaatcac cgacctctct 9120 ccccaggggg tacccagctg tctagagaat tctagatctt gagacaaatg gcagtattca 9180 tccacaattt taaaagaaaa ggggggattg gggggtacag tgcaggggaa agaatagtag 9240 acataatagc aacagacata caaactaaag aattacaaaa acaaattaca aaaattcaaa 9300 attttcgggt ttattacagg gacagcagag atccactttg gcgccggctc gaggggg 9357 <210> 85 <211> 232 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 85 Met Ala Gln Leu Lys Lys Lys Leu Gln Ala Asn Lys Lys Glu Leu Ala 1 5 10 15 Gln Leu Lys Trp Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln Gly 20 25 30 Gly Gly Gly Ser Gly Ser Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu 35 40 45 Gly Lys Gln Asn Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe 50 55 60 Ala Leu Lys Asn Gly Phe Ile Ala Ser Asn Cys His Pro Ala Asp Ile 65 70 75 80 Pro Asp Tyr Tyr Lys Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 85 90 95 Val Met Asn Phe Glu Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr 100 105 110 Ser Leu Glu Asp Gly Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr 115 120 125 Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 130 135 140 Glu Ala Ser Thr Glu Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly 145 150 155 160 Asp Ile Lys Met Ala Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu Ala 165 170 175 Asp Phe Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Met Pro Gly 180 185 190 Ala Tyr Asn Val Asp Arg Lys Leu Asp Ile Thr Ser His Asn Glu Asp 195 200 205 Tyr Thr Val Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His Ser Thr 210 215 220 Gly Gly Met Asp Glu Leu Tyr Lys 225 230 <210> 86 <211> 9432 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 86 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggtgag caagggcgag 660 gcagtgatca aggagttcat gcggttcaag gtgcacatgg agggctccat gaacggccac 720 gagttcgaga tcgagggcga gggcgagggc cgcccctacg agggcaccca gaccgccaag 780 ctgaaggtga ccaagggtgg ccccctgccc ttctcctggg acatcctgtc ccctcagttc 840 atgtacggct ccagggcctt caccaagcac cccgccgaca tccccgacta ctataagcag 900 tccttccccg agggcttcaa gtgggagcgc gtgatgaact tcgaggacgg cggcgccgtg 960 accgtgaccc aggacacctc cctggaggac ggcaccctga tctacaagtg cctttcatac 1020 gagaccgaga tcctgactgt cgagtacgga ttgcttccta tcggcaaaat cgtggagaag 1080 aggattgaat gtaccgtcta ttcagtcgat aataatggga acatctacac acagcccgtg 1140 gctcaatggc acgacagagg agagcaggaa gtttttgaat actgtctcga ggacggatcc 1200 ctcatccgcg ctactaaaga tcataagttt atgaccgtgg acggccagat gctgccaatt 1260 gacgaaattt ttgaacgaga gctggatctg atgagagtcg acaaccttcc aaacggtgga 1320 ggggggtcag gctctgcgca gctggaaaag gagcttcaag ccctcgaaaa aaagttggcc 1380 cagctcgagt gggagaacca ggctctggag aaagaactgg cccagtgatt aattaagaat 1440 tcgacccagc tttcttgtac aaagtggttg gtaagcctat ccctaaccct ctcctcggtc 1500 tcgattctac gtagtaatga gctagcagtc tcgaggttaa cgaattccgc ccccccccta 1560 acgttactgg ccgaagccgc ttggaataag gccggtgtgc gcttgtctat atgttatttt 1620 ccaccatatt gccgtctttt ggcaatgtga gggcccggaa acctggccct gtcttcttga 1680 cgagcattcc taggggtctt tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg 1740 tgaaggaagc agttcctctg gaagcttctt gaagacaaac aacgtctgta gcgacccttt 1800 gcaggcagcg gaacccccca cctggcgaca ggtgcccctg cggccaaaag ccacgtgtat 1860 aagatacacc tgcaaaggcg gcacaacccc agtgccacgt tgtgagttgg atagttgtgg 1920 aaagagtcaa atggctctcc tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg 1980 taccccattg tatgggatct gatctggggc ctcggtgcac atgctttaca tgtgtttagt 2040 cgaggttaaa aaaacgtcta ggccccccga accacgggga cgtggttttc ctttgaaaaa 2100 cacgataata ccatggccat gagcgagctg attaaggaga acatgcacat gaagctgtac 2160 atggagggca ccgtggacaa ccatcacttc aagtgcacat ccgagggcga aggcaagccc 2220 tacgagggca cccagaccat gagaatcaag gtggtcgagg gcggccctct ccccttcgcc 2280 ttcgacatcc tggctactag cttcctctac ggcagcaaga ccttcatcaa ccacacccag 2340 ggcatccccg acttcttcaa gcagtccttc cctgagggct tcacatggga gagagtcacc 2400 acatacgaag acgggggcgt gctgaccgct acccaggaca ccagcctcca ggacggctgc 2460 ctcatctaca acgtcaagat cagaggggtg aacttcacat ccaacggccc tgtgatgcag 2520 aagaaaacac tcggctggga ggccttcacc gagacgctgt accccgctga cggcggcctg 2580 gaaggcagaa acgacatggc cctgaagctc gtgggcggga gccatctgat cgcaaacatc 2640 aagaccacat atagatccaa gaaacccgct aagaacctca agatgcctgg cgtctactat 2700 gtggactaca gactggaaag aatcaaggag gccaacaacg agacctacgt cgagcagcac 2760 gaggtggcag tggccagata ctgcgacctc cctagcaaac tggggcacaa gcttaattaa 2820 caccggtggc gcgttaagtc gacaatcaac ctctggatta caaaatttgt gaaagattga 2880 ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt 2940 tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt 3000 tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg 3060 tgtttgctga cgcaaccccc actggttggg gcattgccac cacctgtcag ctcctttccg 3120 ggactttcgc tttccccctc cctattgcca cggcggaact catcgccgcc tgccttgccc 3180 gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgttg tcggggaaat 3240 catcgtcctt tccttggctg ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct 3300 tctgctacgt cccttcggcc ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg 3360 ctctgcggcc tcttccgcgt cttcgccttc gccctcagac gagtcggatc tccctttggg 3420 ccgcctcccc gcgtcgactt taagaccaat gacttacaag gcagctgtag atcttagcca 3480 ctttttaaaa gaaaaggggg gactggaagg gctaattcac tcccaacgaa gacaagatct 3540 gctttttgct tgtactgggt ctctctggtt agaccagatc tgagcctggg agctctctgg 3600 ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt 3660 gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct tttagtcagt 3720 gtggaaaatc tctagcagta cgtatagtag ttcatgtcat cttattattc agtatttata 3780 acttgcaaag aaatgaatat cagagagtga gaggaacttg tttattgcag cttataatgg 3840 ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc 3900 tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggctct agctatcccg 3960 cccctaactc cgcccatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat 4020 ggctgactaa ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc 4080 cagaagtagt gaggaggctt ttttggaggc ctagggacgt acccaattcg ccctatagtg 4140 agtcgtatta cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg 4200 gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg 4260 aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg 4320 cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta 4380 cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt 4440 tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg 4500 ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat 4560 cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac 4620 tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag 4680 ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg 4740 cgaattttaa caaaatatta acgcttacaa tttaggtggc acttttcggg gaaatgtgcg 4800 cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca 4860 ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt 4920 ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga 4980 aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga 5040 actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat 5100 gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca 5160 agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt 5220 cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac 5280 catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct 5340 aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga 5400 gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac 5460 aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat 5520 agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg 5580 ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc 5640 actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc 5700 aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg 5760 gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta 5820 atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg 5880 tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga 5940 tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt 6000 ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag 6060 agcgcagata ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa 6120 ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag 6180 tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca 6240 gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac 6300 cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa 6360 ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc 6420 agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg 6480 tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc 6540 ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc 6600 ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag 6660 ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa 6720 accgcctctc cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca ggtttcccga 6780 ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt tagctcactc attaggcacc 6840 ccaggcttta cactttatgc ttccggctcg tatgttgtgt ggaattgtga gcggataaca 6900 atttcacaca ggaaacagct atgaccatga ttacgccaag cgcgcaatta accctcacta 6960 aagggaacaa aagctggagc tgcaagctta atgtagtctt atgcaatact cttgtagtct 7020 tgcaacatgg taacgatgag ttagcaacat gccttacaag gagagaaaaa gcaccgtgca 7080 tgccgattgg tggaagtaag gtggtacgat cgtgccttat taggaaggca acagacgggt 7140 ctgacatgga ttggacgaac cactgaattg ccgcattgca gagatattgt atttaagtgc 7200 ctagctcgat acataaacgg gtctctctgg ttagaccaga tctgagcctg ggagctctct 7260 ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt gcttcaagta 7320 gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc cttttagtca 7380 gtgtggaaaa tctctagcag tggcgcccga acagggactt gaaagcgaaa gggaaaccag 7440 aggagctctc tcgacgcagg actcggcttg ctgaagcgcg cacggcaaga ggcgaggggc 7500 ggcgactggt gagtacgcca aaaattttga ctagcggagg ctagaaggag agagatgggt 7560 gcgagagcgt cagtattaag cgggggagaa ttagatcgcg atgggaaaaa attcggttaa 7620 ggccaggggg aaagaaaaaa tataaattaa aacatatagt atgggcaagc agggagctag 7680 aacgattcgc agttaatcct ggcctgttag aaacatcaga aggctgtaga caaatactgg 7740 gacagctaca accatccctt cagacaggat cagaagaact tagatcatta tataatacag 7800 tagcaaccct ctattgtgtg catcaaagga tagagataaa agacaccaag gaagctttag 7860 acaagataga ggaagagcaa aacaaaagta agaccaccgc acagcaagcg gccgctgatc 7920 ttcagacctg gaggaggaga tatgagggac aattggagaa gtgaattata taaatataaa 7980 gtagtaaaaa ttgaaccatt aggagtagca cccaccaagg caaagagaag agtggtgcag 8040 agagaaaaaa gagcagtggg aataggagct ttgttccttg ggttcttggg agcagcagga 8100 agcactatgg gcgcagcgtc aatgacgctg acggtacagg ccagacaatt attgtctggt 8160 atagtgcagc agcagaacaa tttgctgagg gctattgagg cgcaacagca tctgttgcaa 8220 ctcacagtct ggggcatcaa gcagctccag gcaagaatcc tggctgtgga aagataccta 8280 aaggatcaac agctcctggg gatttggggt tgctctggaa aactcatttg caccactgct 8340 gtgccttgga atgctagttg gagtaataaa tctctggaac agatttggaa tcacacgacc 8400 tggatggagt gggacagaga aattaacaat tacacaagct taatacactc cttaattgaa 8460 gaatcgcaaa accagcaaga aaagaatgaa caagaattat tggaattaga taaatgggca 8520 agtttgtgga attggtttaa cataacaaat tggctgtggt atataaaatt attcataatg 8580 atagtaggag gcttggtagg tttaagaata gtttttgctg tactttctat agtgaataga 8640 gttaggcagg gatattcacc attatcgttt cagacccacc tcccaacccc gaggggaccc 8700 ttgcgccttt tccaaggcag ccctgggttt gcgcagggac gcggctgctc tgggcgtggt 8760 tccgggaaac gcagcggcgc cgaccctggg tctcgcacat tcttcacgtc cgttcgcagc 8820 gtcacccgga tcttcgccgc tacccttgtg ggccccccgg cgacgcttcc tgctccgccc 8880 ctaagtcggg aaggttcctt gcggttcgcg gcgtgccgga cgtgacaaac ggaagccgca 8940 cgtctcacta gtaccctcgc agacggacag cgccagggag caatggcagc gcgccgaccg 9000 cgatgggctg tggccaatag cggctgctca gcagggcgcg ccgagagcag cggccgggaa 9060 ggggcggtgc gggaggcggg gtgtggggcg gtagtgtggg ccctgttcct gcccgcgcgg 9120 tgttccgcat tctgcaagcc tccggagcgc acgtcggcag tcggctccct cgttgaccga 9180 atcaccgacc tctctcccca gggggtaccc agctgtctag agaattctag atcttgagac 9240 aaatggcagt attcatccac aattttaaaa gaaaaggggg gattgggggg tacagtgcag 9300 gggaaagaat agtagacata atagcaacag acatacaaac taaagaatta caaaaacaaa 9360 ttacaaaaat tcaaaatttt cgggtttatt acagggacag cagagatcca ctttggcgcc 9420 ggctcgaggg gg 9432 <210> 87 <211> 261 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 87 Met Val Ser Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys 1 5 10 15 Val His Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 20 25 30 Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 35 40 45 Val Thr Lys Gly Gly Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro 50 55 60 Gln Phe Met Tyr Gly Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile 65 70 75 80 Pro Asp Tyr Tyr Lys Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 85 90 95 Val Met Asn Phe Glu Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr 100 105 110 Ser Leu Glu Asp Gly Thr Leu Ile Tyr Lys Cys Leu Ser Tyr Glu Thr 115 120 125 Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val 130 135 140 Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn 145 150 155 160 Ile Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu 165 170 175 Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys 180 185 190 Asp His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu 195 200 205 Ile Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn 210 215 220 Gly Gly Gly Gly Ser Gly Ser Ala Gln Leu Glu Lys Glu Leu Gln Ala 225 230 235 240 Leu Glu Lys Lys Leu Ala Gln Leu Glu Trp Glu Asn Gln Ala Leu Glu 245 250 255 Lys Glu Leu Ala Gln 260 <210> 88 <211> 9216 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 88 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggctca actgaagaag 660 aaactccagg ccaataagaa agaactggca cagctgaagt ggaagctgca ggcactgaaa 720 aagaagctgg cacagggcgg aggaggctca ggcagtatga ttaagatcgc tacgcggaag 780 tacctgggga aacagaacgt ctacgacata ggtgtggagc gcgatcacaa ctttgctctg 840 aaaaatggat ttatcgccag caactgcgtg aagctccgcg gcaccaactt ccctcctgac 900 ggccccgtaa tgcagaagaa gacaatgggc tgggaagcgt ccaccgagcg gttgtacccc 960 gaggacggcg tgctgaaggg cgacattaag atggccctgc gcctgaagga cggcggccgc 1020 tacctggcgg acttcaagac cacctacaag gccaagaagc ccgtgcagat gcccggcgcc 1080 tacaacgtcg accgcaagtt ggacatcacc tcccacaacg aggactacac cgtggtggaa 1140 cagtacgaac gctccgaggg ccgccactcc accggcggca tggacgagct gtacaagtga 1200 ttaattaaga attcgaccca gctttcttgt acaaagtggt tggtaagcct atccctaacc 1260 ctctcctcgg tctcgattct acgtagtaat gagctagcag tctcgaggtt aacgaattcc 1320 gccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt gcgcttgtct 1380 atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc 1440 ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc 1500 tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg 1560 tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcccc tgcggccaaa 1620 agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt 1680 ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg 1740 atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta 1800 catgtgttta gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt 1860 tcctttgaaa aacacgataa taccatggtg agcaagggcg aggagctgtt caccggggtg 1920 gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc 1980 gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc 2040 aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc 2100 agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc 2160 tacgtccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag 2220 gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag 2280 gaggacggca acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat 2340 atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc 2400 gaggacggca gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc 2460 cccgtgctgc tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc 2520 aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc 2580 ggcatggacg agctgtacaa gtaacaccgg tggcgcgtta agtcgacaat caacctctgg 2640 attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct tttacgctat 2700 gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg gctttcattt 2760 tctcctcctt gtataaatcc tggttgctgt ctctttatga ggagttgtgg cccgttgtca 2820 ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt tggggcattg 2880 ccaccacctg tcagctcctt tccgggactt tcgctttccc cctccctatt gccacggcgg 2940 aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg ggcactgaca 3000 attccgtggt gttgtcgggg aaatcatcgt cctttccttg gctgctcgcc tgtgttgcca 3060 cctggattct gcgcgggacg tccttctgct acgtcccttc ggccctcaat ccagcggacc 3120 ttccttcccg cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc cttcgccctc 3180 agacgagtcg gatctccctt tgggccgcct ccccgcgtcg actttaagac caatgactta 3240 caaggcagct gtagatctta gccacttttt aaaagaaaag gggggactgg aagggctaat 3300 tcactcccaa cgaagacaag atctgctttt tgcttgtact gggtctctct ggttagacca 3360 gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag 3420 cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag 3480 atccctcaga cccttttagt cagtgtggaa aatctctagc agtacgtata gtagttcatg 3540 tcatcttatt attcagtatt tataacttgc aaagaaatga atatcagaga gtgagaggaa 3600 cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa 3660 taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta 3720 tcatgtctgg ctctagctat cccgccccta actccgccca tcccgcccct aactccgccc 3780 agttccgccc attctccgcc ccatggctga ctaatttttt ttatttatgc agaggccgag 3840 gccgcctcgg cctctgagct attccagaag tagtgaggag gcttttttgg aggcctaggg 3900 acgtacccaa ttcgccctat agtgagtcgt attacgcgcg ctcactggcc gtcgttttac 3960 aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca gcacatcccc 4020 ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc 4080 gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg 4140 tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt 4200 tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc 4260 tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg 4320 gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg 4380 agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct 4440 cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg 4500 agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttagg 4560 tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc 4620 aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag 4680 gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg 4740 ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt 4800 gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt 4860 tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt 4920 attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa 4980 tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag 5040 agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac 5100 aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac 5160 tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac 5220 cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac 5280 tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact 5340 tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg 5400 tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt 5460 tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat 5520 aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta 5580 gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa 5640 tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga 5700 aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac 5760 aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt 5820 tccgaaggta actggcttca gcagagcgca gataccaaat actgttcttc tagtgtagcc 5880 gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat 5940 cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag 6000 acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc 6060 cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag 6120 cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac 6180 aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg 6240 gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct 6300 atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc 6360 tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga 6420 gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga 6480 agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg 6540 cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt 6600 gagttagctc actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt 6660 gtgtggaatt gtgagcggat aacaatttca cacaggaaac agctatgacc atgattacgc 6720 caagcgcgca attaaccctc actaaaggga acaaaagctg gagctgcaag cttaatgtag 6780 tcttatgcaa tactcttgta gtcttgcaac atggtaacga tgagttagca acatgcctta 6840 caaggagaga aaaagcaccg tgcatgccga ttggtggaag taaggtggta cgatcgtgcc 6900 ttattaggaa ggcaacagac gggtctgaca tggattggac gaaccactga attgccgcat 6960 tgcagagata ttgtatttaa gtgcctagct cgatacataa acgggtctct ctggttagac 7020 cagatctgag cctgggagct ctctggctaa ctagggaacc cactgcttaa gcctcaataa 7080 agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag 7140 agatccctca gaccctttta gtcagtgtgg aaaatctcta gcagtggcgc ccgaacaggg 7200 acttgaaagc gaaagggaaa ccagaggagc tctctcgacg caggactcgg cttgctgaag 7260 cgcgcacggc aagaggcgag gggcggcgac tggtgagtac gccaaaaatt ttgactagcg 7320 gaggctagaa ggagagagat gggtgcgaga gcgtcagtat taagcggggg agaattagat 7380 cgcgatggga aaaaattcgg ttaaggccag ggggaaagaa aaaatataaa ttaaaacata 7440 tagtatgggc aagcagggag ctagaacgat tcgcagttaa tcctggcctg ttagaaacat 7500 cagaaggctg tagacaaata ctgggacagc tacaaccatc ccttcagaca ggatcagaag 7560 aacttagatc attatataat acagtagcaa ccctctattg tgtgcatcaa aggatagaga 7620 taaaagacac caaggaagct ttagacaaga tagaggaaga gcaaaacaaa agtaagacca 7680 ccgcacagca agcggccgct gatcttcaga cctggaggag gagatatgag ggacaattgg 7740 agaagtgaat tatataaata taaagtagta aaaattgaac cattaggagt agcacccacc 7800 aaggcaaaga gaagagtggt gcagagagaa aaaagagcag tgggaatagg agctttgttc 7860 cttgggttct tgggagcagc aggaagcact atgggcgcag cgtcaatgac gctgacggta 7920 caggccagac aattattgtc tggtatagtg cagcagcaga acaatttgct gagggctatt 7980 gaggcgcaac agcatctgtt gcaactcaca gtctggggca tcaagcagct ccaggcaaga 8040 atcctggctg tggaaagata cctaaaggat caacagctcc tggggatttg gggttgctct 8100 ggaaaactca tttgcaccac tgctgtgcct tggaatgcta gttggagtaa taaatctctg 8160 gaacagattt ggaatcacac gacctggatg gagtgggaca gagaaattaa caattacaca 8220 agcttaatac actccttaat tgaagaatcg caaaaccagc aagaaaagaa tgaacaagaa 8280 ttattggaat tagataaatg ggcaagtttg tggaattggt ttaacataac aaattggctg 8340 tggtatataa aattattcat aatgatagta ggaggcttgg taggtttaag aatagttttt 8400 gctgtacttt ctatagtgaa tagagttagg cagggatatt caccattatc gtttcagacc 8460 cacctcccaa ccccgagggg acccttgcgc cttttccaag gcagccctgg gtttgcgcag 8520 ggacgcggct gctctgggcg tggttccggg aaacgcagcg gcgccgaccc tgggtctcgc 8580 acattcttca cgtccgttcg cagcgtcacc cggatcttcg ccgctaccct tgtgggcccc 8640 ccggcgacgc ttcctgctcc gcccctaagt cgggaaggtt ccttgcggtt cgcggcgtgc 8700 cggacgtgac aaacggaagc cgcacgtctc actagtaccc tcgcagacgg acagcgccag 8760 ggagcaatgg cagcgcgccg accgcgatgg gctgtggcca atagcggctg ctcagcaggg 8820 cgcgccgaga gcagcggccg ggaaggggcg gtgcgggagg cggggtgtgg ggcggtagtg 8880 tgggccctgt tcctgcccgc gcggtgttcc gcattctgca agcctccgga gcgcacgtcg 8940 gcagtcggct ccctcgttga ccgaatcacc gacctctctc cccagggggt acccagctgt 9000 ctagagaatt ctagatcttg agacaaatgg cagtattcat ccacaatttt aaaagaaaag 9060 gggggattgg ggggtacagt gcaggggaaa gaatagtaga cataatagca acagacatac 9120 aaactaaaga attacaaaaa caaattacaa aaattcaaaa ttttcgggtt tattacaggg 9180 acagcagaga tccactttgg cgccggctcg aggggg 9216 <210> 89 <211> 185 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 89 Met Ala Gln Leu Lys Lys Lys Leu Gln Ala Asn Lys Lys Glu Leu Ala 1 5 10 15 Gln Leu Lys Trp Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln Gly 20 25 30 Gly Gly Gly Ser Gly Ser Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu 35 40 45 Gly Lys Gln Asn Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe 50 55 60 Ala Leu Lys Asn Gly Phe Ile Ala Ser Asn Cys Val Lys Leu Arg Gly 65 70 75 80 Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly 85 90 95 Trp Glu Ala Ser Thr Glu Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys 100 105 110 Gly Asp Ile Lys Met Ala Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu 115 120 125 Ala Asp Phe Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Met Pro 130 135 140 Gly Ala Tyr Asn Val Asp Arg Lys Leu Asp Ile Thr Ser His Asn Glu 145 150 155 160 Asp Tyr Thr Val Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His Ser 165 170 175 Thr Gly Gly Met Asp Glu Leu Tyr Lys 180 185 <210> 90 <211> 9486 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 90 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggtgag caagggcgag 660 gcagtgatca aggagttcat gcggttcaag gtgcacatgg agggctccat gaacggccac 720 gagttcgaga tcgagggcga gggcgagggc cgcccctacg agggcaccca gaccgccaag 780 ctgaaggtga ccaagggtgg ccccctgccc ttctcctggg acatcctgtc ccctcagttc 840 atgtacggct ccagggcctt caccaagcac cccgccgaca tccccgacta ctataagcag 900 tccttccccg agggcttcaa gtgggagcgc gtgatgaact tcgaggacgg cggcgccgtg 960 accgtgaccc aggacacctc cctggaggac ggcaccctga tctacaaggt gaagctccgc 1020 ggcaccaact tccctcctga cggccccgta atgcagaaga agtgcctttc atacgagacc 1080 gagatcctga ctgtcgagta cggattgctt cctatcggca aaatcgtgga gaagaggatt 1140 gaatgtaccg tctattcagt cgataataat gggaacatct acacacagcc cgtggctcaa 1200 tggcacgaca gaggagagca ggaagttttt gaatactgtc tcgaggacgg atccctcatc 1260 cgcgctacta aagatcataa gtttatgacc gtggacggcc agatgctgcc aattgacgaa 1320 atttttgaac gagagctgga tctgatgaga gtcgacaacc ttccaaacgg tggagggggg 1380 tcaggctctg cgcagctgga aaaggagctt caagccctcg aaaaaaagtt ggcccagctc 1440 gagtgggaga accaggctct ggagaaagaa ctggcccagt gattaattaa gaattcgacc 1500 cagctttctt gtacaaagtg gttggtaagc ctatccctaa ccctctcctc ggtctcgatt 1560 ctacgtagta atgagctagc agtctcgagg ttaacgaatt ccgccccccc cctaacgtta 1620 ctggccgaag ccgcttggaa taaggccggt gtgcgcttgt ctatatgtta ttttccacca 1680 tattgccgtc ttttggcaat gtgagggccc ggaaacctgg ccctgtcttc ttgacgagca 1740 ttcctagggg tctttcccct ctcgccaaag gaatgcaagg tctgttgaat gtcgtgaagg 1800 aagcagttcc tctggaagct tcttgaagac aaacaacgtc tgtagcgacc ctttgcaggc 1860 agcggaaccc cccacctggc gacaggtgcc cctgcggcca aaagccacgt gtataagata 1920 cacctgcaaa ggcggcacaa ccccagtgcc acgttgtgag ttggatagtt gtggaaagag 1980 tcaaatggct ctcctcaagc gtattcaaca aggggctgaa ggatgcccag aaggtacccc 2040 attgtatggg atctgatctg gggcctcggt gcacatgctt tacatgtgtt tagtcgaggt 2100 taaaaaaacg tctaggcccc ccgaaccacg gggacgtggt tttcctttga aaaacacgat 2160 aataccatgg ccatgagcga gctgattaag gagaacatgc acatgaagct gtacatggag 2220 ggcaccgtgg acaaccatca cttcaagtgc acatccgagg gcgaaggcaa gccctacgag 2280 ggcacccaga ccatgagaat caaggtggtc gagggcggcc ctctcccctt cgccttcgac 2340 atcctggcta ctagcttcct ctacggcagc aagaccttca tcaaccacac ccagggcatc 2400 cccgacttct tcaagcagtc cttccctgag ggcttcacat gggagagagt caccacatac 2460 gaagacgggg gcgtgctgac cgctacccag gacaccagcc tccaggacgg ctgcctcatc 2520 tacaacgtca agatcagagg ggtgaacttc acatccaacg gccctgtgat gcagaagaaa 2580 acactcggct gggaggcctt caccgagacg ctgtaccccg ctgacggcgg cctggaaggc 2640 agaaacgaca tggccctgaa gctcgtgggc gggagccatc tgatcgcaaa catcaagacc 2700 acatatagat ccaagaaacc cgctaagaac ctcaagatgc ctggcgtcta ctatgtggac 2760 tacagactgg aaagaatcaa ggaggccaac aacgagacct acgtcgagca gcacgaggtg 2820 gcagtggcca gatactgcga cctccctagc aaactggggc acaagcttaa ttaacaccgg 2880 tggcgcgtta agtcgacaat caacctctgg attacaaaat ttgtgaaaga ttgactggta 2940 ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc 3000 atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt 3060 ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg 3120 ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt 3180 tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct 3240 ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt 3300 cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct 3360 acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc 3420 ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct 3480 ccccgcgtcg actttaagac caatgactta caaggcagct gtagatctta gccacttttt 3540 aaaagaaaag gggggactgg aagggctaat tcactcccaa cgaagacaag atctgctttt 3600 tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact 3660 agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc 3720 ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa 3780 aatctctagc agtacgtata gtagttcatg tcatcttatt attcagtatt tataacttgc 3840 aaagaaatga atatcagaga gtgagaggaa cttgtttatt gcagcttata atggttacaa 3900 ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg 3960 tggtttgtcc aaactcatca atgtatctta tcatgtctgg ctctagctat cccgccccta 4020 actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga 4080 ctaatttttt ttatttatgc agaggccgag gccgcctcgg cctctgagct attccagaag 4140 tagtgaggag gcttttttgg aggcctaggg acgtacccaa ttcgccctat agtgagtcgt 4200 attacgcgcg ctcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta 4260 cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg 4320 cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg gacgcgccct 4380 gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg 4440 ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg 4500 gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac 4560 ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct 4620 gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt 4680 tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta taagggattt 4740 tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt 4800 ttaacaaaat attaacgctt acaatttagg tggcactttt cggggaaatg tgcgcggaac 4860 ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc 4920 ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt 4980 cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct 5040 ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga 5100 tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag 5160 cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca 5220 actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga 5280 aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag 5340 tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc 5400 ttttttgcac aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa 5460 tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt 5520 gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg 5580 gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt 5640 tattgctgat aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg 5700 gccagatggt aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat 5760 ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact 5820 gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa 5880 aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt 5940 ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt 6000 ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg 6060 tttgccggat caagagctac caactctttt tccgaaggta actggcttca gcagagcgca 6120 gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca agaactctgt 6180 agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga 6240 taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc 6300 gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact 6360 gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga 6420 caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg 6480 aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt 6540 tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt 6600 acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga 6660 ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac 6720 gaccgagcgc agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc 6780 tctccccgcg cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa 6840 agcgggcagt gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc 6900 tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca 6960 cacaggaaac agctatgacc atgattacgc caagcgcgca attaaccctc actaaaggga 7020 acaaaagctg gagctgcaag cttaatgtag tcttatgcaa tactcttgta gtcttgcaac 7080 atggtaacga tgagttagca acatgcctta caaggagaga aaaagcaccg tgcatgccga 7140 ttggtggaag taaggtggta cgatcgtgcc ttattaggaa ggcaacagac gggtctgaca 7200 tggattggac gaaccactga attgccgcat tgcagagata ttgtatttaa gtgcctagct 7260 cgatacataa acgggtctct ctggttagac cagatctgag cctgggagct ctctggctaa 7320 ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca agtagtgtgt 7380 gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta gtcagtgtgg 7440 aaaatctcta gcagtggcgc ccgaacaggg acttgaaagc gaaagggaaa ccagaggagc 7500 tctctcgacg caggactcgg cttgctgaag cgcgcacggc aagaggcgag gggcggcgac 7560 tggtgagtac gccaaaaatt ttgactagcg gaggctagaa ggagagagat gggtgcgaga 7620 gcgtcagtat taagcggggg agaattagat cgcgatggga aaaaattcgg ttaaggccag 7680 ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag ctagaacgat 7740 tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata ctgggacagc 7800 tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat acagtagcaa 7860 ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct ttagacaaga 7920 tagaggaaga gcaaaacaaa agtaagacca ccgcacagca agcggccgct gatcttcaga 7980 cctggaggag gagatatgag ggacaattgg agaagtgaat tatataaata taaagtagta 8040 aaaattgaac cattaggagt agcacccacc aaggcaaaga gaagagtggt gcagagagaa 8100 aaaagagcag tgggaatagg agctttgttc cttgggttct tgggagcagc aggaagcact 8160 atgggcgcag cgtcaatgac gctgacggta caggccagac aattattgtc tggtatagtg 8220 cagcagcaga acaatttgct gagggctatt gaggcgcaac agcatctgtt gcaactcaca 8280 gtctggggca tcaagcagct ccaggcaaga atcctggctg tggaaagata cctaaaggat 8340 caacagctcc tggggatttg gggttgctct ggaaaactca tttgcaccac tgctgtgcct 8400 tggaatgcta gttggagtaa taaatctctg gaacagattt ggaatcacac gacctggatg 8460 gagtgggaca gagaaattaa caattacaca agcttaatac actccttaat tgaagaatcg 8520 caaaaccagc aagaaaagaa tgaacaagaa ttattggaat tagataaatg ggcaagtttg 8580 tggaattggt ttaacataac aaattggctg tggtatataa aattattcat aatgatagta 8640 ggaggcttgg taggtttaag aatagttttt gctgtacttt ctatagtgaa tagagttagg 8700 cagggatatt caccattatc gtttcagacc cacctcccaa ccccgagggg acccttgcgc 8760 cttttccaag gcagccctgg gtttgcgcag ggacgcggct gctctgggcg tggttccggg 8820 aaacgcagcg gcgccgaccc tgggtctcgc acattcttca cgtccgttcg cagcgtcacc 8880 cggatcttcg ccgctaccct tgtgggcccc ccggcgacgc ttcctgctcc gcccctaagt 8940 cgggaaggtt ccttgcggtt cgcggcgtgc cggacgtgac aaacggaagc cgcacgtctc 9000 actagtaccc tcgcagacgg acagcgccag ggagcaatgg cagcgcgccg accgcgatgg 9060 gctgtggcca atagcggctg ctcagcaggg cgcgccgaga gcagcggccg ggaaggggcg 9120 gtgcgggagg cggggtgtgg ggcggtagtg tgggccctgt tcctgcccgc gcggtgttcc 9180 gcattctgca agcctccgga gcgcacgtcg gcagtcggct ccctcgttga ccgaatcacc 9240 gacctctctc cccagggggt acccagctgt ctagagaatt ctagatcttg agacaaatgg 9300 cagtattcat ccacaatttt aaaagaaaag gggggattgg ggggtacagt gcaggggaaa 9360 gaatagtaga cataatagca acagacatac aaactaaaga attacaaaaa caaattacaa 9420 aaattcaaaa ttttcgggtt tattacaggg acagcagaga tccactttgg cgccggctcg 9480 aggggg 9486 <210> 91 <211> 279 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 91 Met Val Ser Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys 1 5 10 15 Val His Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 20 25 30 Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 35 40 45 Val Thr Lys Gly Gly Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro 50 55 60 Gln Phe Met Tyr Gly Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile 65 70 75 80 Pro Asp Tyr Tyr Lys Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 85 90 95 Val Met Asn Phe Glu Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr 100 105 110 Ser Leu Glu Asp Gly Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr 115 120 125 Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Cys Leu Ser Tyr 130 135 140 Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys 145 150 155 160 Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn 165 170 175 Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu 180 185 190 Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala 195 200 205 Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile 210 215 220 Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu 225 230 235 240 Pro Asn Gly Gly Gly Gly Ser Gly Ser Ala Gln Leu Glu Lys Glu Leu 245 250 255 Gln Ala Leu Glu Lys Lys Leu Ala Gln Leu Glu Trp Glu Asn Gln Ala 260 265 270 Leu Glu Lys Glu Leu Ala Gln 275 <210> 92 <211> 9162 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 92 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggctca actgaagaag 660 aaactccagg ccaataagaa agaactggca cagctgaagt ggaagctgca ggcactgaaa 720 aagaagctgg cacagggcgg aggaggctca ggcagtatga ttaagatcgc tacgcggaag 780 tacctgggga aacagaacgt ctacgacata ggtgtggagc gcgatcacaa ctttgctctg 840 aaaaatggat ttatcgccag caactgcaca atgggctggg aagcgtccac cgagcggttg 900 taccccgagg acggcgtgct gaagggcgac attaagatgg ccctgcgcct gaaggacggc 960 ggccgctacc tggcggactt caagaccacc tacaaggcca agaagcccgt gcagatgccc 1020 ggcgcctaca acgtcgaccg caagttggac atcacctccc acaacgagga ctacaccgtg 1080 gtggaacagt acgaacgctc cgagggccgc cactccaccg gcggcatgga cgagctgtac 1140 aagtgattaa ttaagaattc gacccagctt tcttgtacaa agtggttggt aagcctatcc 1200 ctaaccctct cctcggtctc gattctacgt agtaatgagc tagcagtctc gaggttaacg 1260 aattccgccc cccccctaac gttactggcc gaagccgctt ggaataaggc cggtgtgcgc 1320 ttgtctatat gttattttcc accatattgc cgtcttttgg caatgtgagg gcccggaaac 1380 ctggccctgt cttcttgacg agcattccta ggggtctttc ccctctcgcc aaaggaatgc 1440 aaggtctgtt gaatgtcgtg aaggaagcag ttcctctgga agcttcttga agacaaacaa 1500 cgtctgtagc gaccctttgc aggcagcgga accccccacc tggcgacagg tgcccctgcg 1560 gccaaaagcc acgtgtataa gatacacctg caaaggcggc acaaccccag tgccacgttg 1620 tgagttggat agttgtggaa agagtcaaat ggctctcctc aagcgtattc aacaaggggc 1680 tgaaggatgc ccagaaggta ccccattgta tgggatctga tctggggcct cggtgcacat 1740 gctttacatg tgtttagtcg aggttaaaaa aacgtctagg ccccccgaac cacggggacg 1800 tggttttcct ttgaaaaaca cgataatacc atggtgagca agggcgagga gctgttcacc 1860 ggggtggtgc ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg 1920 tccggcgagg gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc 1980 accggcaagc tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag 2040 tgcttcagcc gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc 2100 gaaggctacg tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc 2160 gccgaggtga agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac 2220 ttcaaggagg acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac 2280 gtctatatca tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac 2340 aacatcgagg acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc 2400 gacggccccg tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa 2460 gaccccaacg agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc 2520 actctcggca tggacgagct gtacaagtaa caccggtggc gcgttaagtc gacaatcaac 2580 ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta 2640 cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt 2700 tcattttctc ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg 2760 ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg 2820 gcattgccac cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca 2880 cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca 2940 ctgacaattc cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg 3000 ttgccacctg gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag 3060 cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc 3120 gccctcagac gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat 3180 gacttacaag gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg 3240 gctaattcac tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt 3300 agaccagatc tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca 3360 ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa 3420 ctagagatcc ctcagaccct tttagtcagt gtggaaaatc tctagcagta cgtatagtag 3480 ttcatgtcat cttattattc agtatttata acttgcaaag aaatgaatat cagagagtga 3540 gaggaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 3600 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 3660 atcttatcat gtctggctct agctatcccg cccctaactc cgcccatccc gcccctaact 3720 ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag 3780 gccgaggccg cctcggcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc 3840 ctagggacgt acccaattcg ccctatagtg agtcgtatta cgcgcgctca ctggccgtcg 3900 ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc cttgcagcac 3960 atcccccttt cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac 4020 agttgcgcag cctgaatggc gaatgggacg cgccctgtag cggcgcatta agcgcggcgg 4080 gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt 4140 tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc 4200 gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg 4260 attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga 4320 cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc 4380 ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa 4440 aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta acgcttacaa 4500 tttaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat 4560 acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg 4620 aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc 4680 attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga 4740 tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga 4800 gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg 4860 cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc 4920 tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac 4980 agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact 5040 tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca 5100 tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg 5160 tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact 5220 acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg 5280 accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg 5340 tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat 5400 cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc 5460 tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat 5520 actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt 5580 tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc 5640 cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt 5700 gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac 5760 tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt 5820 gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct 5880 gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga 5940 ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac 6000 acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg 6060 agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt 6120 cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc 6180 tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg 6240 gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc 6300 ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc 6360 ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag 6420 cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca 6480 ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc gcaacgcaat 6540 taatgtgagt tagctcactc attaggcacc ccaggcttta cactttatgc ttccggctcg 6600 tatgttgtgt ggaattgtga gcggataaca atttcacaca ggaaacagct atgaccatga 6660 ttacgccaag cgcgcaatta accctcacta aagggaacaa aagctggagc tgcaagctta 6720 atgtagtctt atgcaatact cttgtagtct tgcaacatgg taacgatgag ttagcaacat 6780 gccttacaag gagagaaaaa gcaccgtgca tgccgattgg tggaagtaag gtggtacgat 6840 cgtgccttat taggaaggca acagacgggt ctgacatgga ttggacgaac cactgaattg 6900 ccgcattgca gagatattgt atttaagtgc ctagctcgat acataaacgg gtctctctgg 6960 ttagaccaga tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct 7020 caataaagct tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt 7080 aactagagat ccctcagacc cttttagtca gtgtggaaaa tctctagcag tggcgcccga 7140 acagggactt gaaagcgaaa gggaaaccag aggagctctc tcgacgcagg actcggcttg 7200 ctgaagcgcg cacggcaaga ggcgaggggc ggcgactggt gagtacgcca aaaattttga 7260 ctagcggagg ctagaaggag agagatgggt gcgagagcgt cagtattaag cgggggagaa 7320 ttagatcgcg atgggaaaaa attcggttaa ggccaggggg aaagaaaaaa tataaattaa 7380 aacatatagt atgggcaagc agggagctag aacgattcgc agttaatcct ggcctgttag 7440 aaacatcaga aggctgtaga caaatactgg gacagctaca accatccctt cagacaggat 7500 cagaagaact tagatcatta tataatacag tagcaaccct ctattgtgtg catcaaagga 7560 tagagataaa agacaccaag gaagctttag acaagataga ggaagagcaa aacaaaagta 7620 agaccaccgc acagcaagcg gccgctgatc ttcagacctg gaggaggaga tatgagggac 7680 aattggagaa gtgaattata taaatataaa gtagtaaaaa ttgaaccatt aggagtagca 7740 cccaccaagg caaagagaag agtggtgcag agagaaaaaa gagcagtggg aataggagct 7800 ttgttccttg ggttcttggg agcagcagga agcactatgg gcgcagcgtc aatgacgctg 7860 acggtacagg ccagacaatt attgtctggt atagtgcagc agcagaacaa tttgctgagg 7920 gctattgagg cgcaacagca tctgttgcaa ctcacagtct ggggcatcaa gcagctccag 7980 gcaagaatcc tggctgtgga aagataccta aaggatcaac agctcctggg gatttggggt 8040 tgctctggaa aactcatttg caccactgct gtgccttgga atgctagttg gagtaataaa 8100 tctctggaac agatttggaa tcacacgacc tggatggagt gggacagaga aattaacaat 8160 tacacaagct taatacactc cttaattgaa gaatcgcaaa accagcaaga aaagaatgaa 8220 caagaattat tggaattaga taaatgggca agtttgtgga attggtttaa cataacaaat 8280 tggctgtggt atataaaatt attcataatg atagtaggag gcttggtagg tttaagaata 8340 gtttttgctg tactttctat agtgaataga gttaggcagg gatattcacc attatcgttt 8400 cagacccacc tcccaacccc gaggggaccc ttgcgccttt tccaaggcag ccctgggttt 8460 gcgcagggac gcggctgctc tgggcgtggt tccgggaaac gcagcggcgc cgaccctggg 8520 tctcgcacat tcttcacgtc cgttcgcagc gtcacccgga tcttcgccgc tacccttgtg 8580 ggccccccgg cgacgcttcc tgctccgccc ctaagtcggg aaggttcctt gcggttcgcg 8640 gcgtgccgga cgtgacaaac ggaagccgca cgtctcacta gtaccctcgc agacggacag 8700 cgccagggag caatggcagc gcgccgaccg cgatgggctg tggccaatag cggctgctca 8760 gcagggcgcg ccgagagcag cggccgggaa ggggcggtgc gggaggcggg gtgtggggcg 8820 gtagtgtggg ccctgttcct gcccgcgcgg tgttccgcat tctgcaagcc tccggagcgc 8880 acgtcggcag tcggctccct cgttgaccga atcaccgacc tctctcccca gggggtaccc 8940 agctgtctag agaattctag atcttgagac aaatggcagt attcatccac aattttaaaa 9000 gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata atagcaacag 9060 acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt cgggtttatt 9120 acagggacag cagagatcca ctttggcgcc ggctcgaggg gg 9162 <210> 93 <211> 167 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 93 Met Ala Gln Leu Lys Lys Lys Leu Gln Ala Asn Lys Lys Glu Leu Ala 1 5 10 15 Gln Leu Lys Trp Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln Gly 20 25 30 Gly Gly Gly Ser Gly Ser Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu 35 40 45 Gly Lys Gln Asn Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe 50 55 60 Ala Leu Lys Asn Gly Phe Ile Ala Ser Asn Cys Thr Met Gly Trp Glu 65 70 75 80 Ala Ser Thr Glu Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly Asp 85 90 95 Ile Lys Met Ala Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu Ala Asp 100 105 110 Phe Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Met Pro Gly Ala 115 120 125 Tyr Asn Val Asp Arg Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr 130 135 140 Thr Val Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His Ser Thr Gly 145 150 155 160 Gly Met Asp Glu Leu Tyr Lys 165 <210> 94 <211> 9555 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 94 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggtgag caagggcgag 660 gcagtgatca aggagttcat gcggttcaag gtgcacatgg agggctccat gaacggccac 720 gagttcgaga tcgagggcga gggcgagggc cgcccctacg agggcaccca gaccgccaag 780 ctgaaggtga ccaagggtgg ccccctgccc ttctcctggg acatcctgtc ccctcagttc 840 atgtacggct ccagggcctt caccaagcac cccgccgaca tccccgacta ctataagcag 900 tccttccccg agggcttcaa gtgggagcgc gtgatgaact tcgaggacgg cggcgccgtg 960 accgtgaccc aggacacctc cctggaggac ggcaccctga tctacaaggt gaagctccgc 1020 ggcaccaact tccctcctga cggccccgta atgcagaaga agacaatggg ctgggaagcg 1080 tccaccgagc ggttgtaccc cgaggacggc gtgctgaagg gcgacattaa gtgcctttca 1140 tacgagaccg agatcctgac tgtcgagtac ggattgcttc ctatcggcaa aatcgtggag 1200 aagaggattg aatgtaccgt ctattcagtc gataataatg ggaacatcta cacacagccc 1260 gtggctcaat ggcacgacag aggagagcag gaagtttttg aatactgtct cgaggacgga 1320 tccctcatcc gcgctactaa agatcataag tttatgaccg tggacggcca gatgctgcca 1380 attgacgaaa tttttgaacg agagctggat ctgatgagag tcgacaacct tccaaacggt 1440 ggaggggggt caggctctgc gcagctggaa aaggagcttc aagccctcga aaaaaagttg 1500 gcccagctcg agtgggagaa ccaggctctg gagaaagaac tggcccagtg attaattaag 1560 aattcgaccc agctttcttg tacaaagtgg ttggtaagcc tatccctaac cctctcctcg 1620 gtctcgattc tacgtagtaa tgagctagca gtctcgaggt taacgaattc cgcccccccc 1680 ctaacgttac tggccgaagc cgcttggaat aaggccggtg tgcgcttgtc tatatgttat 1740 tttccaccat attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct 1800 tgacgagcat tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg 1860 tcgtgaagga agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc 1920 tttgcaggca gcggaacccc ccacctggcg acaggtgccc ctgcggccaa aagccacgtg 1980 tataagatac acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg 2040 tggaaagagt caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga 2100 aggtacccca ttgtatggga tctgatctgg ggcctcggtg cacatgcttt acatgtgttt 2160 agtcgaggtt aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa 2220 aaacacgata ataccatggc catgagcgag ctgattaagg agaacatgca catgaagctg 2280 tacatggagg gcaccgtgga caaccatcac ttcaagtgca catccgaggg cgaaggcaag 2340 ccctacgagg gcacccagac catgagaatc aaggtggtcg agggcggccc tctccccttc 2400 gccttcgaca tcctggctac tagcttcctc tacggcagca agaccttcat caaccacacc 2460 cagggcatcc ccgacttctt caagcagtcc ttccctgagg gcttcacatg ggagagagtc 2520 accacatacg aagacggggg cgtgctgacc gctacccagg acaccagcct ccaggacggc 2580 tgcctcatct acaacgtcaa gatcagaggg gtgaacttca catccaacgg ccctgtgatg 2640 cagaagaaaa cactcggctg ggaggccttc accgagacgc tgtaccccgc tgacggcggc 2700 ctggaaggca gaaacgacat ggccctgaag ctcgtgggcg ggagccatct gatcgcaaac 2760 atcaagacca catatagatc caagaaaccc gctaagaacc tcaagatgcc tggcgtctac 2820 tatgtggact acagactgga aagaatcaag gaggccaaca acgagaccta cgtcgagcag 2880 cacgaggtgg cagtggccag atactgcgac ctccctagca aactggggca caagcttaat 2940 taacaccggt ggcgcgttaa gtcgacaatc aacctctgga ttacaaaatt tgtgaaagat 3000 tgactggtat tcttaactat gttgctcctt ttacgctatg tggatacgct gctttaatgc 3060 ctttgtatca tgctattgct tcccgtatgg ctttcatttt ctcctccttg tataaatcct 3120 ggttgctgtc tctttatgag gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca 3180 ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc caccacctgt cagctccttt 3240 ccgggacttt cgctttcccc ctccctattg ccacggcgga actcatcgcc gcctgccttg 3300 cccgctgctg gacaggggct cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga 3360 aatcatcgtc ctttccttgg ctgctcgcct gtgttgccac ctggattctg cgcgggacgt 3420 ccttctgcta cgtcccttcg gccctcaatc cagcggacct tccttcccgc ggcctgctgc 3480 cggctctgcg gcctcttccg cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt 3540 gggccgcctc cccgcgtcga ctttaagacc aatgacttac aaggcagctg tagatcttag 3600 ccacttttta aaagaaaagg ggggactgga agggctaatt cactcccaac gaagacaaga 3660 tctgcttttt gcttgtactg ggtctctctg gttagaccag atctgagcct gggagctctc 3720 tggctaacta gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt 3780 agtgtgtgcc cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc 3840 agtgtggaaa atctctagca gtacgtatag tagttcatgt catcttatta ttcagtattt 3900 ataacttgca aagaaatgaa tatcagagag tgagaggaac ttgtttattg cagcttataa 3960 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 4020 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctggc tctagctatc 4080 ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc 4140 catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc ctctgagcta 4200 ttccagaagt agtgaggagg cttttttgga ggcctaggga cgtacccaat tcgccctata 4260 gtgagtcgta ttacgcgcgc tcactggccg tcgttttaca acgtcgtgac tgggaaaacc 4320 ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc tggcgtaata 4380 gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggg 4440 acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg 4500 ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca 4560 cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta 4620 gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc 4680 catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg 4740 gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat 4800 aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta 4860 acgcgaattt taacaaaata ttaacgctta caatttaggt ggcacttttc ggggaaatgt 4920 gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag 4980 acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca 5040 tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc 5100 agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat 5160 cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc 5220 aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg 5280 gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc 5340 agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat 5400 aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga 5460 gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc 5520 ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc 5580 aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt 5640 aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc 5700 tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc 5760 agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca 5820 ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca 5880 ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa aacttcattt 5940 ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta 6000 acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg 6060 agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc 6120 ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag 6180 cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc accacttcaa 6240 gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc 6300 cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc 6360 gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta 6420 caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag 6480 aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct 6540 tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga 6600 gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc 6660 ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt 6720 atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg 6780 cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcccaatacg 6840 caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg acaggtttcc 6900 cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca ctcattaggc 6960 accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg tgagcggata 7020 acaatttcac acaggaaaca gctatgacca tgattacgcc aagcgcgcaa ttaaccctca 7080 ctaaagggaa caaaagctgg agctgcaagc ttaatgtagt cttatgcaat actcttgtag 7140 tcttgcaaca tggtaacgat gagttagcaa catgccttac aaggagagaa aaagcaccgt 7200 gcatgccgat tggtggaagt aaggtggtac gatcgtgcct tattaggaag gcaacagacg 7260 ggtctgacat ggattggacg aaccactgaa ttgccgcatt gcagagatat tgtatttaag 7320 tgcctagctc gatacataaa cgggtctctc tggttagacc agatctgagc ctgggagctc 7380 tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgcttcaa 7440 gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag 7500 tcagtgtgga aaatctctag cagtggcgcc cgaacaggga cttgaaagcg aaagggaaac 7560 cagaggagct ctctcgacgc aggactcggc ttgctgaagc gcgcacggca agaggcgagg 7620 ggcggcgact ggtgagtacg ccaaaaattt tgactagcgg aggctagaag gagagagatg 7680 ggtgcgagag cgtcagtatt aagcggggga gaattagatc gcgatgggaa aaaattcggt 7740 taaggccagg gggaaagaaa aaatataaat taaaacatat agtatgggca agcagggagc 7800 tagaacgatt cgcagttaat cctggcctgt tagaaacatc agaaggctgt agacaaatac 7860 tgggacagct acaaccatcc cttcagacag gatcagaaga acttagatca ttatataata 7920 cagtagcaac cctctattgt gtgcatcaaa ggatagagat aaaagacacc aaggaagctt 7980 tagacaagat agaggaagag caaaacaaaa gtaagaccac cgcacagcaa gcggccgctg 8040 atcttcagac ctggaggagg agatatgagg gacaattgga gaagtgaatt atataaatat 8100 aaagtagtaa aaattgaacc attaggagta gcacccacca aggcaaagag aagagtggtg 8160 cagagagaaa aaagagcagt gggaatagga gctttgttcc ttgggttctt gggagcagca 8220 ggaagcacta tgggcgcagc gtcaatgacg ctgacggtac aggccagaca attattgtct 8280 ggtatagtgc agcagcagaa caatttgctg agggctattg aggcgcaaca gcatctgttg 8340 caactcacag tctggggcat caagcagctc caggcaagaa tcctggctgt ggaaagatac 8400 ctaaaggatc aacagctcct ggggatttgg ggttgctctg gaaaactcat ttgcaccact 8460 gctgtgcctt ggaatgctag ttggagtaat aaatctctgg aacagatttg gaatcacacg 8520 acctggatgg agtgggacag agaaattaac aattacacaa gcttaataca ctccttaatt 8580 gaagaatcgc aaaaccagca agaaaagaat gaacaagaat tattggaatt agataaatgg 8640 gcaagtttgt ggaattggtt taacataaca aattggctgt ggtatataaa attattcata 8700 atgatagtag gaggcttggt aggtttaaga atagtttttg ctgtactttc tatagtgaat 8760 agagttaggc agggatattc accattatcg tttcagaccc acctcccaac cccgagggga 8820 cccttgcgcc ttttccaagg cagccctggg tttgcgcagg gacgcggctg ctctgggcgt 8880 ggttccggga aacgcagcgg cgccgaccct gggtctcgca cattcttcac gtccgttcgc 8940 agcgtcaccc ggatcttcgc cgctaccctt gtgggccccc cggcgacgct tcctgctccg 9000 cccctaagtc gggaaggttc cttgcggttc gcggcgtgcc ggacgtgaca aacggaagcc 9060 gcacgtctca ctagtaccct cgcagacgga cagcgccagg gagcaatggc agcgcgccga 9120 ccgcgatggg ctgtggccaa tagcggctgc tcagcagggc gcgccgagag cagcggccgg 9180 gaaggggcgg tgcgggaggc ggggtgtggg gcggtagtgt gggccctgtt cctgcccgcg 9240 cggtgttccg cattctgcaa gcctccggag cgcacgtcgg cagtcggctc cctcgttgac 9300 cgaatcaccg acctctctcc ccagggggta cccagctgtc tagagaattc tagatcttga 9360 gacaaatggc agtattcatc cacaatttta aaagaaaagg ggggattggg gggtacagtg 9420 caggggaaag aatagtagac ataatagcaa cagacataca aactaaagaa ttacaaaaac 9480 aaattacaaa aattcaaaat tttcgggttt attacaggga cagcagagat ccactttggc 9540 gccggctcga ggggg 9555 <210> 95 <211> 302 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 95 Met Val Ser Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys 1 5 10 15 Val His Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 20 25 30 Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 35 40 45 Val Thr Lys Gly Gly Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro 50 55 60 Gln Phe Met Tyr Gly Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile 65 70 75 80 Pro Asp Tyr Tyr Lys Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 85 90 95 Val Met Asn Phe Glu Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr 100 105 110 Ser Leu Glu Asp Gly Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr 115 120 125 Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 130 135 140 Glu Ala Ser Thr Glu Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly 145 150 155 160 Asp Ile Lys Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr 165 170 175 Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr 180 185 190 Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala 195 200 205 Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu 210 215 220 Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val 225 230 235 240 Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp 245 250 255 Leu Met Arg Val Asp Asn Leu Pro Asn Gly Gly Gly Gly Ser Gly Ser 260 265 270 Ala Gln Leu Glu Lys Glu Leu Gln Ala Leu Glu Lys Lys Leu Ala Gln 275 280 285 Leu Glu Trp Glu Asn Gln Ala Leu Glu Lys Glu Leu Ala Gln 290 295 300 <210> 96 <211> 9093 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 96 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggctca actgaagaag 660 aaactccagg ccaataagaa agaactggca cagctgaagt ggaagctgca ggcactgaaa 720 aagaagctgg cacagggcgg aggaggctca ggcagtatga ttaagatcgc tacgcggaag 780 tacctgggga aacagaacgt ctacgacata ggtgtggagc gcgatcacaa ctttgctctg 840 aaaaatggat ttatcgccag caactgcatg gccctgcgcc tgaaggacgg cggccgctac 900 ctggcggact tcaagaccac ctacaaggcc aagaagcccg tgcagatgcc cggcgcctac 960 aacgtcgacc gcaagttgga catcacctcc cacaacgagg actacaccgt ggtggaacag 1020 tacgaacgct ccgagggccg ccactccacc ggcggcatgg acgagctgta caagtgatta 1080 attaagaatt cgacccagct ttcttgtaca aagtggttgg taagcctatc cctaaccctc 1140 tcctcggtct cgattctacg tagtaatgag ctagcagtct cgaggttaac gaattccgcc 1200 ccccccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg cttgtctata 1260 tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg 1320 tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg caaggtctgt 1380 tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca acgtctgtag 1440 cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcccctgc ggccaaaagc 1500 cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga 1560 tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg ctgaaggatg 1620 cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca tgctttacat 1680 gtgtttagtc gaggttaaaa aaacgtctag gccccccgaa ccacggggac gtggttttcc 1740 tttgaaaaac acgataatac catggtgagc aagggcgagg agctgttcac cggggtggtg 1800 cccatcctgg tcgagctgga cggcgacgta aacggccaca agttcagcgt gtccggcgag 1860 ggcgagggcg atgccaccta cggcaagctg accctgaagt tcatctgcac caccggcaag 1920 ctgcccgtgc cctggcccac cctcgtgacc accctgacct acggcgtgca gtgcttcagc 1980 cgctaccccg accacatgaa gcagcacgac ttcttcaagt ccgccatgcc cgaaggctac 2040 gtccaggagc gcaccatctt cttcaaggac gacggcaact acaagacccg cgccgaggtg 2100 aagttcgagg gcgacaccct ggtgaaccgc atcgagctga agggcatcga cttcaaggag 2160 gacggcaaca tcctggggca caagctggag tacaactaca acagccacaa cgtctatatc 2220 atggccgaca agcagaagaa cggcatcaag gtgaacttca agatccgcca caacatcgag 2280 gacggcagcg tgcagctcgc cgaccactac cagcagaaca cccccatcgg cgacggcccc 2340 gtgctgctgc ccgacaacca ctacctgagc acccagtccg ccctgagcaa agaccccaac 2400 gagaagcgcg atcacatggt cctgctggag ttcgtgaccg ccgccgggat cactctcggc 2460 atggacgagc tgtacaagta acaccggtgg cgcgttaagt cgacaatcaa cctctggatt 2520 acaaaatttg tgaaagattg actggtattc ttaactatgt tgctcctttt acgctatgtg 2580 gatacgctgc tttaatgcct ttgtatcatg ctattgcttc ccgtatggct ttcattttct 2640 cctccttgta taaatcctgg ttgctgtctc tttatgagga gttgtggccc gttgtcaggc 2700 aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc cactggttgg ggcattgcca 2760 ccacctgtca gctcctttcc gggactttcg ctttccccct ccctattgcc acggcggaac 2820 tcatcgccgc ctgccttgcc cgctgctgga caggggctcg gctgttgggc actgacaatt 2880 ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct gctcgcctgt gttgccacct 2940 ggattctgcg cgggacgtcc ttctgctacg tcccttcggc cctcaatcca gcggaccttc 3000 cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg tcttcgcctt cgccctcaga 3060 cgagtcggat ctccctttgg gccgcctccc cgcgtcgact ttaagaccaa tgacttacaa 3120 ggcagctgta gatcttagcc actttttaaa agaaaagggg ggactggaag ggctaattca 3180 ctcccaacga agacaagatc tgctttttgc ttgtactggg tctctctggt tagaccagat 3240 ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc aataaagctt 3300 gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta actagagatc 3360 cctcagaccc ttttagtcag tgtggaaaat ctctagcagt acgtatagta gttcatgtca 3420 tcttattatt cagtatttat aacttgcaaa gaaatgaata tcagagagtg agaggaactt 3480 gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa 3540 agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca 3600 tgtctggctc tagctatccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt 3660 tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc 3720 gcctcggcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctagggacg 3780 tacccaattc gccctatagt gagtcgtatt acgcgcgctc actggccgtc gttttacaac 3840 gtcgtgactg ggaaaaccct ggcgttaccc aacttaatcg ccttgcagca catccccctt 3900 tcgccagctg gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa cagttgcgca 3960 gcctgaatgg cgaatgggac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg 4020 ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct 4080 tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc 4140 ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt gattagggtg 4200 atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt 4260 ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg 4320 tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta aaaaatgagc 4380 tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgcttaca atttaggtgg 4440 cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa 4500 tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa 4560 gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct 4620 tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg 4680 tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg 4740 ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt 4800 atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga 4860 cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga 4920 attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac 4980 gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg 5040 ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac 5100 gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct 5160 agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct 5220 gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg 5280 gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat 5340 ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg 5400 tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat 5460 tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct 5520 catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa 5580 gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa 5640 aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc 5700 gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag tgtagccgta 5760 gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct 5820 gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg 5880 atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag 5940 cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc 6000 cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg 6060 agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt 6120 tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg 6180 gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca 6240 catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg 6300 agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc 6360 ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag 6420 ctggcacgac aggtttcccg actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag 6480 ttagctcact cattaggcac cccaggcttt acactttatg cttccggctc gtatgttgtg 6540 tggaattgtg agcggataac aatttcacac aggaaacagc tatgaccatg attacgccaa 6600 gcgcgcaatt aaccctcact aaagggaaca aaagctggag ctgcaagctt aatgtagtct 6660 tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca tgccttacaa 6720 ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga tcgtgcctta 6780 ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt gccgcattgc 6840 agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg gttagaccag 6900 atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc tcaataaagc 6960 ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg taactagaga 7020 tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg aacagggact 7080 tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt gctgaagcgc 7140 gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg actagcggag 7200 gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga attagatcgc 7260 gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta aaacatatag 7320 tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta gaaacatcag 7380 aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga tcagaagaac 7440 ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg atagagataa 7500 aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt aagaccaccg 7560 cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga caattggaga 7620 agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc acccaccaag 7680 gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc tttgttcctt 7740 gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct gacggtacag 7800 gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag ggctattgag 7860 gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca ggcaagaatc 7920 ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg ttgctctgga 7980 aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa atctctggaa 8040 cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa ttacacaagc 8100 ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga acaagaatta 8160 ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa ttggctgtgg 8220 tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat agtttttgct 8280 gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt tcagacccac 8340 ctcccaaccc cgaggggacc cttgcgcctt ttccaaggca gccctgggtt tgcgcaggga 8400 cgcggctgct ctgggcgtgg ttccgggaaa cgcagcggcg ccgaccctgg gtctcgcaca 8460 ttcttcacgt ccgttcgcag cgtcacccgg atcttcgccg ctacccttgt gggccccccg 8520 gcgacgcttc ctgctccgcc cctaagtcgg gaaggttcct tgcggttcgc ggcgtgccgg 8580 acgtgacaaa cggaagccgc acgtctcact agtaccctcg cagacggaca gcgccaggga 8640 gcaatggcag cgcgccgacc gcgatgggct gtggccaata gcggctgctc agcagggcgc 8700 gccgagagca gcggccggga aggggcggtg cgggaggcgg ggtgtggggc ggtagtgtgg 8760 gccctgttcc tgcccgcgcg gtgttccgca ttctgcaagc ctccggagcg cacgtcggca 8820 gtcggctccc tcgttgaccg aatcaccgac ctctctcccc agggggtacc cagctgtcta 8880 gagaattcta gatcttgaga caaatggcag tattcatcca caattttaaa agaaaagggg 8940 ggattggggg gtacagtgca ggggaaagaa tagtagacat aatagcaaca gacatacaaa 9000 ctaaagaatt acaaaaacaa attacaaaaa ttcaaaattt tcgggtttat tacagggaca 9060 gcagagatcc actttggcgc cggctcgagg ggg 9093 <210> 97 <211> 144 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 97 Met Ala Gln Leu Lys Lys Lys Leu Gln Ala Asn Lys Lys Glu Leu Ala 1 5 10 15 Gln Leu Lys Trp Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln Gly 20 25 30 Gly Gly Gly Ser Gly Ser Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu 35 40 45 Gly Lys Gln Asn Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe 50 55 60 Ala Leu Lys Asn Gly Phe Ile Ala Ser Asn Cys Met Ala Leu Arg Leu 65 70 75 80 Lys Asp Gly Gly Arg Tyr Leu Ala Asp Phe Lys Thr Thr Tyr Lys Ala 85 90 95 Lys Lys Pro Val Gln Met Pro Gly Ala Tyr Asn Val Asp Arg Lys Leu 100 105 110 Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Val Val Glu Gln Tyr Glu 115 120 125 Arg Ser Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 130 135 140 <210> 98 <211> 3530 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 98 ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga 60 taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga 120 gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca 180 cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaata cgcgtaccgc 240 tagccaggaa gagtttgtag aaacgcaaaa aggccatccg tcaggatggc cttctgctta 300 gtttgatgcc tggcagttta tggcgggcgt cctgcccgcc accctccggg ccgttgcttc 360 acaacgatca aatccgctcc cggcggattt gtcctactca ggagagcgtt caccgacaaa 420 caacagataa aacgaaaggc ccagtcttcc gactgagcct ttcgttttat ttgatgcctg 480 gcagttccct actctcgcgt taacgctagc atggatgttt tcccagtcac gacgttgtaa 540 aacgacggcc agtcttaagc tcgggcccca aataatgatt ttattttgac tgatagtgac 600 ctgttcgttg caacaaattg atgagcaatg cttttttata atgccaactt tgtacaaaaa 660 agcaggctcc gaattcaccg gtgccgccac catgagcgag ctgattaagg agaacatgca 720 catgaagctg tacatggagg gcaccgtgga caaccatcac ttcaagtgca catccgaggg 780 cgaaggcaag ccctacgagg gcacccagac catgagaatc aaggtggtcg agggcggccc 840 tctccccttc gccttcgaca tcctggctac tagcttcctc tacggcagca agaccttcat 900 caaccacacc cagggcatcc ccgacttctt caagcagtcc ttccctgagg gcttcacatg 960 ggagagagtc accacatacg aagacggggg cgtgctgacc gctacccagg acaccagcct 1020 ccaggacggc tgcctcatct acaacgtcaa gatcagaggg gtgaacttca catccaacgg 1080 ccctgtgatg cagaagaaaa cactcggctg ggaggccttc accgagacgc tgtaccccgc 1140 tgacggcggc ctggaaggca gaaacgacat ggccctgaag ctcgtgggcg ggagccatct 1200 gatcgcaaac atcaagacca catatagatc caagaaaccc gctaagaacc tcaagatgcc 1260 tggcgtctac tatgtggact acagactgga aagaatcaag gaggccaaca acgagaccta 1320 cgtcgagcag cacgaggtgg cagtggccag atactgcgac ctccctagca aactggggca 1380 caagcttaat taattaatta agaattcgac ccagctttct tgtacaaagt tggcattata 1440 aaaaataatt gctcatcaat ttgttgcaac gaacaggtca ctatcagtca aaataaaatc 1500 attatttgcc atccagctga tatcccctat agtgagtcgt attacatggt catagctgtt 1560 tcctggcagc tctggcccgt gtctcaaaat ctctgatgtt acattgcaca agataaaaat 1620 atatcatcat gcctcctcta gaccagccag gacagaaatg cctcgacttc gctgctgccc 1680 aaggttgccg ggtgacgcac accgtggaaa cggatgaagg cacgaaccca gtggacataa 1740 gcctgttcgg ttcgtaagct gtaatgcaag tagcgtatgc gctcacgcaa ctggtccaga 1800 accttgaccg aacgcagcgg tggtaacggc gcagtggcgg ttttcatggc ttgttatgac 1860 tgtttttttg gggtacagtc tatgcctcgg gcatccaagc agcaagcgcg ttacgccgtg 1920 ggtcgatgtt tgatgttatg gagcagcaac gatgttacgc agcagggcag tcgccctaaa 1980 acaaagttaa acatcatgag ggaagcggtg atcgccgaag tatcgactca actatcagag 2040 gtagttggcg tcatcgagcg ccatctcgaa ccgacgttgc tggccgtaca tttgtacggc 2100 tccgcagtgg atggcggcct gaagccacac agtgatattg atttgctggt tacggtgacc 2160 gtaaggcttg atgaaacaac gcggcgagct ttgatcaacg accttttgga aacttcggct 2220 tcccctggag agagcgagat tctccgcgct gtagaagtca ccattgttgt gcacgacgac 2280 atcattccgt ggcgttatcc agctaagcgc gaactgcaat ttggagaatg gcagcgcaat 2340 gacattcttg caggtatctt cgagccagcc acgatcgaca ttgatctggc tatcttgctg 2400 acaaaagcaa gagaacatag cgttgccttg gtaggtccag cggcggagga actctttgat 2460 ccggttcctg aacaggatct atttgaggcg ctaaatgaaa ccttaacgct atggaactcg 2520 ccgcccgact gggctggcga tgagcgaaat gtagtgctta cgttgtcccg catttggtac 2580 agcgcagtaa ccggcaaaat cgcgccgaag gatgtcgctg ccgactgggc aatggagcgc 2640 ctgccggccc agtatcagcc cgtcatactt gaagctagac aggcttatct tggacaagaa 2700 gaagatcgct tggcctcgcg cgcagatcag ttggaagaat ttgtccacta cgtgaaaggc 2760 gagatcacca aggtagtcgg caaataaccc tcgagccacc catgaccaaa atcccttaac 2820 gtgagttacg cgtcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct 2880 tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca 2940 gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc 3000 agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc 3060 aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct 3120 gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag 3180 gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc 3240 tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg 3300 agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag 3360 cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt 3420 gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac 3480 gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt 3530 <210> 99 <211> 233 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 99 Met Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu 1 5 10 15 Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly 20 25 30 Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly 35 40 45 Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr 50 55 60 Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe 65 70 75 80 Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr 85 90 95 Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp 100 105 110 Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser 115 120 125 Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr 130 135 140 Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met 145 150 155 160 Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr 165 170 175 Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val 180 185 190 Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu 195 200 205 Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu 210 215 220 Pro Ser Lys Leu Gly His Lys Leu Asn 225 230 <210> 100 <211> 3539 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 100 ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga 60 taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga 120 gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca 180 cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaata cgcgtaccgc 240 tagccaggaa gagtttgtag aaacgcaaaa aggccatccg tcaggatggc cttctgctta 300 gtttgatgcc tggcagttta tggcgggcgt cctgcccgcc accctccggg ccgttgcttc 360 acaacgatca aatccgctcc cggcggattt gtcctactca ggagagcgtt caccgacaaa 420 caacagataa aacgaaaggc ccagtcttcc gactgagcct ttcgttttat ttgatgcctg 480 gcagttccct actctcgcgt taacgctagc atggatgttt tcccagtcac gacgttgtaa 540 aacgacggcc agtcttaagc tcgggcccca aataatgatt ttattttgac tgatagtgac 600 ctgttcgttg caacaaattg atgagcaatg cttttttata atgccaactt tgtacaaaaa 660 agcaggctcc gaattcaccg gtgccgccac catggtgagc aagggcgagg aggataacat 720 ggccatcatc aaggagttca tgcgcttcaa ggtgcacatg gagggctccg tgaacggcca 780 cgagttcgag atcgagggcg agggcgaggg ccgcccctac gagggcaccc agaccgccaa 840 gctgaaggtg accaagggtg gccccctgcc cttcgcctgg gacatcctgt cccctcagtt 900 catgtacggc tccaaggcct acgtgaagca ccccgccgac atccccgact acttgaagct 960 gtccttcccc gagggcttca agtgggagcg cgtgatgaac ttcgaggacg gcggcgtggt 1020 gaccgtgacc caggactcct ccctgcagga cggcgagttc atctacaagg tgaagctgcg 1080 cggcaccaac ttcccctccg acggccccgt aatgcagaag aagaccatgg gctgggaggc 1140 ctcctccgag cggatgtacc ccgaggacgg cgccctgaag ggcgagatca agcagaggct 1200 gaagctgaag gacggcggcc actacgacgc tgaggtcaag accacctaca aggccaagaa 1260 gcccgtgcag ctgcccggcg cctacaacgt caacattaag ttggacatca cctcccacaa 1320 cgaggactac accatcgtgg aacagtacga acgcgccgag ggccgccact ccaccggcgg 1380 catggacgag ctgtacaagt gattaattaa gaattcgacc cagctttctt gtacaaagtt 1440 ggcattataa aaaataattg ctcatcaatt tgttgcaacg aacaggtcac tatcagtcaa 1500 aataaaatca ttatttgcca tccagctgat atcccctata gtgagtcgta ttacatggtc 1560 atagctgttt cctggcagct ctggcccgtg tctcaaaatc tctgatgtta cattgcacaa 1620 gataaaaata tatcatcatg cctcctctag accagccagg acagaaatgc ctcgacttcg 1680 ctgctgccca aggttgccgg gtgacgcaca ccgtggaaac ggatgaaggc acgaacccag 1740 tggacataag cctgttcggt tcgtaagctg taatgcaagt agcgtatgcg ctcacgcaac 1800 tggtccagaa ccttgaccga acgcagcggt ggtaacggcg cagtggcggt tttcatggct 1860 tgttatgact gtttttttgg ggtacagtct atgcctcggg catccaagca gcaagcgcgt 1920 tacgccgtgg gtcgatgttt gatgttatgg agcagcaacg atgttacgca gcagggcagt 1980 cgccctaaaa caaagttaaa catcatgagg gaagcggtga tcgccgaagt atcgactcaa 2040 ctatcagagg tagttggcgt catcgagcgc catctcgaac cgacgttgct ggccgtacat 2100 ttgtacggct ccgcagtgga tggcggcctg aagccacaca gtgatattga tttgctggtt 2160 acggtgaccg taaggcttga tgaaacaacg cggcgagctt tgatcaacga ccttttggaa 2220 acttcggctt cccctggaga gagcgagatt ctccgcgctg tagaagtcac cattgttgtg 2280 cacgacgaca tcattccgtg gcgttatcca gctaagcgcg aactgcaatt tggagaatgg 2340 cagcgcaatg acattcttgc aggtatcttc gagccagcca cgatcgacat tgatctggct 2400 atcttgctga caaaagcaag agaacatagc gttgccttgg taggtccagc ggcggaggaa 2460 ctctttgatc cggttcctga acaggatcta tttgaggcgc taaatgaaac cttaacgcta 2520 tggaactcgc cgcccgactg ggctggcgat gagcgaaatg tagtgcttac gttgtcccgc 2580 atttggtaca gcgcagtaac cggcaaaatc gcgccgaagg atgtcgctgc cgactgggca 2640 atggagcgcc tgccggccca gtatcagccc gtcatacttg aagctagaca ggcttatctt 2700 ggacaagaag aagatcgctt ggcctcgcgc gcagatcagt tggaagaatt tgtccactac 2760 gtgaaaggcg agatcaccaa ggtagtcggc aaataaccct cgagccaccc atgaccaaaa 2820 tcccttaacg tgagttacgc gtcgttccac tgagcgtcag accccgtaga aaagatcaaa 2880 ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca 2940 ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta 3000 actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc 3060 caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca 3120 gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta 3180 ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag 3240 cgaacgacct acaccgaact gagataccta cagcgtgagc attgagaaag cgccacgctt 3300 cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc 3360 acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac 3420 ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac 3480 gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgtt 3539 <210> 101 <211> 236 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 101 Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 1 5 10 15 Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 20 25 30 Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 35 40 45 Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 50 55 60 Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 65 70 75 80 Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 85 90 95 Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 100 105 110 Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 115 120 125 Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 130 135 140 Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 145 150 155 160 Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 165 170 175 His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 180 185 190 Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 195 200 205 His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 210 215 220 Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 225 230 235 <210> 102 <211> 10137 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 102 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagctgaacg agaaacgtaa aatgatataa atatcaatat attaaattag 660 attttgcata aaaaacagac tacataatac tgtaaaacac aacatatcca gtcactatgg 720 cggccgcatt aggcacccca ggctttacac tttatgcttc cggctcgtat aatgtgtgga 780 ttttgagtta ggatccgtcg agattttcag gagctaagga agctaaaatg gagaaaaaaa 840 tcactggata taccaccgtt gatatatccc aatggcatcg taaagaacat tttgaggcat 900 ttcagtcagt tgctcaatgt acctataacc agaccgttca gctggatatt acggcctttt 960 taaagaccgt aaagaaaaat aagcacaagt tttatccggc ctttattcac attcttgccc 1020 gcctgatgaa tgctcatccg gaattccgta tggcaatgaa agacggtgag ctggtgatat 1080 gggatagtgt tcacccttgt tacaccgttt tccatgagca aactgaaacg ttttcatcgc 1140 tctggagtga ataccacgac gatttccggc agtttctaca catatattcg caagatgtgg 1200 cgtgttacgg tgaaaacctg gcctatttcc ctaaagggtt tattgagaat atgtttttcg 1260 tctcagccaa tccctgggtg agtttcacca gttttgattt aaacgtggcc aatatggaca 1320 acttcttcgc ccccgttttc accatgggca aatattatac gcaaggcgac aaggtgctga 1380 tgccgctggc gattcaggtt catcatgccg tttgtgatgg cttccatgtc ggcagaatgc 1440 ttaatgaatt acaacagtac tgcgatgagt ggcagggcgg ggcgtaaaga tctggatccg 1500 gcttactaaa agccagataa cagtatgcgt atttgcgcgc tgatttttgc ggtataagaa 1560 tatatactga tatgtatacc cgaagtatgt caaaaagagg tatgctatga agcagcgtat 1620 tacagtgaca gttgacagcg acagctatca gttgctcaag gcatatatga tgtcaatatc 1680 tccggtctgg taagcacaac catgcagaat gaagcccgtc gtctgcgtgc cgaacgctgg 1740 aaagcggaaa atcaggaagg gatggctgag gtcgcccggt ttattgaaat gaacggctct 1800 tttgctgacg agaacagggg ctggtgaaat gcagtttaag gtttacacct ataaaagaga 1860 gagccgttat cgtctgtttg tggatgtaca gagtgatatt attgacacgc ccgggcgacg 1920 gatggtgatc cccctggcca gtgcacgtct gctgtcagat aaagtctccc gtgaacttta 1980 cccggtggtg catatcgggg atgaaagctg gcgcatgatg accaccgata tggccagtgt 2040 gccggtctcc gttatcgggg aagaagtggc tgatctcagc caccgcgaaa atgacatcaa 2100 aaacgccatt aacctgatgt tctggggaat ataaatgtca ggctccctta tacacagcca 2160 gtctgcaggt cgaccatagt gactggatat gttgtgtttt acagtattat gtagtctgtt 2220 ttttatgcaa aatctaattt aatatattga tatttatatc attttacgtt tctcgttcag 2280 ctttcttgta caaagtggtt ggtaagccta tccctaaccc tctcctcggt ctcgattcta 2340 cgtagtaatg agctagcagt ctcgaggtta acgaattccg ccccccccct aacgttactg 2400 gccgaagccg cttggaataa ggccggtgtg cgcttgtcta tatgttattt tccaccatat 2460 tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc 2520 ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag 2580 cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc 2640 ggaacccccc acctggcgac aggtgcccct gcggccaaaa gccacgtgta taagatacac 2700 ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca 2760 aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt 2820 gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa 2880 aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgataat 2940 accatggcca tgaaaaagcc tgaactcacc gcgacgtctg tcgagaagtt tctgatcgaa 3000 aagttcgaca gcgtctccga cctgatgcag ctctcggagg gcgaagaatc tcgtgctttc 3060 agcttcgatg taggagggcg tggatatgtc ctgcgggtaa atagctgcgc cgatggtttc 3120 tacaaagatc gttatgttta tcggcacttt gcatcggccg cgctcccgat tccggaagtg 3180 cttgacattg gggaatttag cgagagcctg acctattgcc tttcatacga gaccgagatc 3240 ctgactgtcg agtacggatt gcttcctatc ggcaaaatcg tggagaagag gattgaatgt 3300 accgtctatt cagtcgataa taatgggaac atctacacac agcccgtggc tcaatggcac 3360 gacagaggag agcaggaagt ttttgaatac tgtctcgagg acggatccct catccgcgct 3420 actaaagatc ataagtttat gaccgtggac ggccagatgc tgccaattga cgaaattttt 3480 gaacgagagc tggatctgat gagagtcgac aaccttccaa actgacaccg gtggcgcgtt 3540 aagtcgacaa tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact 3600 atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg 3660 cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg 3720 aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa 3780 cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc 3840 ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg 3900 ctcggctgtt gggcactgac aattccgtgg tgttgtcggg gaaatcatcg tcctttcctt 3960 ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt 4020 cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc 4080 cgcgtcttcg ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgcgtc 4140 gactttaaga ccaatgactt acaaggcagc tgtagatctt agccactttt taaaagaaaa 4200 ggggggactg gaagggctaa ttcactccca acgaagacaa gatctgcttt ttgcttgtac 4260 tgggtctctc tggttagacc agatctgagc ctgggagctc tctggctaac tagggaaccc 4320 actgcttaag cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg cccgtctgtt 4380 gtgtgactct ggtaactaga gatccctcag acccttttag tcagtgtgga aaatctctag 4440 cagtacgtat agtagttcat gtcatcttat tattcagtat ttataacttg caaagaaatg 4500 aatatcagag agtgagagga acttgtttat tgcagcttat aatggttaca aataaagcaa 4560 tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc 4620 caaactcatc aatgtatctt atcatgtctg gctctagcta tcccgcccct aactccgccc 4680 atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt 4740 tttatttatg cagaggccga ggccgcctcg gcctctgagc tattccagaa gtagtgagga 4800 ggcttttttg gaggcctagg gacgtaccca attcgcccta tagtgagtcg tattacgcgc 4860 gctcactggc cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta 4920 atcgccttgc agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg 4980 atcgcccttc ccaacagttg cgcagcctga atggcgaatg ggacgcgccc tgtagcggcg 5040 cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc 5100 tagcgcccgc tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc 5160 gtcaagctct aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg 5220 accccaaaaa acttgattag ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg 5280 tttttcgccc tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg 5340 gaacaacact caaccctatc tcggtctatt cttttgattt ataagggatt ttgccgattt 5400 cggcctattg gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa 5460 tattaacgct tacaatttag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg 5520 tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat 5580 gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat 5640 tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt 5700 aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag 5760 cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa 5820 agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg 5880 ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct 5940 tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac 6000 tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca 6060 caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat 6120 accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact 6180 attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc 6240 ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga 6300 taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg 6360 taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg 6420 aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca 6480 agtttactca tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta 6540 ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca 6600 ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg 6660 cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga 6720 tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa 6780 tactgttctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc 6840 tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg 6900 tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac 6960 ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct 7020 acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc 7080 ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg 7140 gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg 7200 ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct 7260 ggccttttgc tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga 7320 taaccgtatt accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg 7380 cagcgagtca gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc 7440 gcgttggccg attcattaat gcagctggca cgacaggttt cccgactgga aagcgggcag 7500 tgagcgcaac gcaattaatg tgagttagct cactcattag gcaccccagg ctttacactt 7560 tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc acacaggaaa 7620 cagctatgac catgattacg ccaagcgcgc aattaaccct cactaaaggg aacaaaagct 7680 ggagctgcaa gcttaatgta gtcttatgca atactcttgt agtcttgcaa catggtaacg 7740 atgagttagc aacatgcctt acaaggagag aaaaagcacc gtgcatgccg attggtggaa 7800 gtaaggtggt acgatcgtgc cttattagga aggcaacaga cgggtctgac atggattgga 7860 cgaaccactg aattgccgca ttgcagagat attgtattta agtgcctagc tcgatacata 7920 aacgggtctc tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac 7980 ccactgctta agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg 8040 ttgtgtgact ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct 8100 agcagtggcg cccgaacagg gacttgaaag cgaaagggaa accagaggag ctctctcgac 8160 gcaggactcg gcttgctgaa gcgcgcacgg caagaggcga ggggcggcga ctggtgagta 8220 cgccaaaaat tttgactagc ggaggctaga aggagagaga tgggtgcgag agcgtcagta 8280 ttaagcgggg gagaattaga tcgcgatggg aaaaaattcg gttaaggcca gggggaaaga 8340 aaaaatataa attaaaacat atagtatggg caagcaggga gctagaacga ttcgcagtta 8400 atcctggcct gttagaaaca tcagaaggct gtagacaaat actgggacag ctacaaccat 8460 cccttcagac aggatcagaa gaacttagat cattatataa tacagtagca accctctatt 8520 gtgtgcatca aaggatagag ataaaagaca ccaaggaagc tttagacaag atagaggaag 8580 agcaaaacaa aagtaagacc accgcacagc aagcggccgc tgatcttcag acctggagga 8640 ggagatatga gggacaattg gagaagtgaa ttatataaat ataaagtagt aaaaattgaa 8700 ccattaggag tagcacccac caaggcaaag agaagagtgg tgcagagaga aaaaagagca 8760 gtgggaatag gagctttgtt ccttgggttc ttgggagcag caggaagcac tatgggcgca 8820 gcgtcaatga cgctgacggt acaggccaga caattattgt ctggtatagt gcagcagcag 8880 aacaatttgc tgagggctat tgaggcgcaa cagcatctgt tgcaactcac agtctggggc 8940 atcaagcagc tccaggcaag aatcctggct gtggaaagat acctaaagga tcaacagctc 9000 ctggggattt ggggttgctc tggaaaactc atttgcacca ctgctgtgcc ttggaatgct 9060 agttggagta ataaatctct ggaacagatt tggaatcaca cgacctggat ggagtgggac 9120 agagaaatta acaattacac aagcttaata cactccttaa ttgaagaatc gcaaaaccag 9180 caagaaaaga atgaacaaga attattggaa ttagataaat gggcaagttt gtggaattgg 9240 tttaacataa caaattggct gtggtatata aaattattca taatgatagt aggaggcttg 9300 gtaggtttaa gaatagtttt tgctgtactt tctatagtga atagagttag gcagggatat 9360 tcaccattat cgtttcagac ccacctccca accccgaggg gacccttgcg ccttttccaa 9420 ggcagccctg ggtttgcgca gggacgcggc tgctctgggc gtggttccgg gaaacgcagc 9480 ggcgccgacc ctgggtctcg cacattcttc acgtccgttc gcagcgtcac ccggatcttc 9540 gccgctaccc ttgtgggccc cccggcgacg cttcctgctc cgcccctaag tcgggaaggt 9600 tccttgcggt tcgcggcgtg ccggacgtga caaacggaag ccgcacgtct cactagtacc 9660 ctcgcagacg gacagcgcca gggagcaatg gcagcgcgcc gaccgcgatg ggctgtggcc 9720 aatagcggct gctcagcagg gcgcgccgag agcagcggcc gggaaggggc ggtgcgggag 9780 gcggggtgtg gggcggtagt gtgggccctg ttcctgcccg cgcggtgttc cgcattctgc 9840 aagcctccgg agcgcacgtc ggcagtcggc tccctcgttg accgaatcac cgacctctct 9900 ccccaggggg tacccagctg tctagagaat tctagatctt gagacaaatg gcagtattca 9960 tccacaattt taaaagaaaa ggggggattg gggggtacag tgcaggggaa agaatagtag 10020 acataatagc aacagacata caaactaaag aattacaaaa acaaattaca aaaattcaaa 10080 attttcgggt ttattacagg gacagcagag atccactttg gcgccggctc gaggggg 10137 <210> 103 <211> 193 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 103 Met Ala Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe 1 5 10 15 Leu Ile Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu 20 25 30 Gly Glu Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr 35 40 45 Val Leu Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr 50 55 60 Val Tyr Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu 65 70 75 80 Asp Ile Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Leu Ser Tyr Glu 85 90 95 Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile 100 105 110 Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly 115 120 125 Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln 130 135 140 Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr 145 150 155 160 Lys Asp His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp 165 170 175 Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro 180 185 190 Asn <210> 104 <211> 10428 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 104 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagctgaacg agaaacgtaa aatgatataa atatcaatat attaaattag 660 attttgcata aaaaacagac tacataatac tgtaaaacac aacatatcca gtcactatgg 720 cggccgcatt aggcacccca ggctttacac tttatgcttc cggctcgtat aatgtgtgga 780 ttttgagtta ggatccgtcg agattttcag gagctaagga agctaaaatg gagaaaaaaa 840 tcactggata taccaccgtt gatatatccc aatggcatcg taaagaacat tttgaggcat 900 ttcagtcagt tgctcaatgt acctataacc agaccgttca gctggatatt acggcctttt 960 taaagaccgt aaagaaaaat aagcacaagt tttatccggc ctttattcac attcttgccc 1020 gcctgatgaa tgctcatccg gaattccgta tggcaatgaa agacggtgag ctggtgatat 1080 gggatagtgt tcacccttgt tacaccgttt tccatgagca aactgaaacg ttttcatcgc 1140 tctggagtga ataccacgac gatttccggc agtttctaca catatattcg caagatgtgg 1200 cgtgttacgg tgaaaacctg gcctatttcc ctaaagggtt tattgagaat atgtttttcg 1260 tctcagccaa tccctgggtg agtttcacca gttttgattt aaacgtggcc aatatggaca 1320 acttcttcgc ccccgttttc accatgggca aatattatac gcaaggcgac aaggtgctga 1380 tgccgctggc gattcaggtt catcatgccg tttgtgatgg cttccatgtc ggcagaatgc 1440 ttaatgaatt acaacagtac tgcgatgagt ggcagggcgg ggcgtaaaga tctggatccg 1500 gcttactaaa agccagataa cagtatgcgt atttgcgcgc tgatttttgc ggtataagaa 1560 tatatactga tatgtatacc cgaagtatgt caaaaagagg tatgctatga agcagcgtat 1620 tacagtgaca gttgacagcg acagctatca gttgctcaag gcatatatga tgtcaatatc 1680 tccggtctgg taagcacaac catgcagaat gaagcccgtc gtctgcgtgc cgaacgctgg 1740 aaagcggaaa atcaggaagg gatggctgag gtcgcccggt ttattgaaat gaacggctct 1800 tttgctgacg agaacagggg ctggtgaaat gcagtttaag gtttacacct ataaaagaga 1860 gagccgttat cgtctgtttg tggatgtaca gagtgatatt attgacacgc ccgggcgacg 1920 gatggtgatc cccctggcca gtgcacgtct gctgtcagat aaagtctccc gtgaacttta 1980 cccggtggtg catatcgggg atgaaagctg gcgcatgatg accaccgata tggccagtgt 2040 gccggtctcc gttatcgggg aagaagtggc tgatctcagc caccgcgaaa atgacatcaa 2100 aaacgccatt aacctgatgt tctggggaat ataaatgtca ggctccctta tacacagcca 2160 gtctgcaggt cgaccatagt gactggatat gttgtgtttt acagtattat gtagtctgtt 2220 ttttatgcaa aatctaattt aatatattga tatttatatc attttacgtt tctcgttcag 2280 ctttcttgta caaagtggtt ggtaagccta tccctaaccc tctcctcggt ctcgattcta 2340 cgtagtaatg agctagcagt ctcgaggtta acgaattccg ccccccccct aacgttactg 2400 gccgaagccg cttggaataa ggccggtgtg cgcttgtcta tatgttattt tccaccatat 2460 tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc 2520 ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag 2580 cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc 2640 ggaacccccc acctggcgac aggtgcccct gcggccaaaa gccacgtgta taagatacac 2700 ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca 2760 aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt 2820 gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa 2880 aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgataat 2940 accatggcca tgattaagat cgctacgcgg aagtacctgg ggaaacagaa cgtctacgac 3000 ataggtgtgg agcgcgatca caactttgct ctgaaaaatg gatttatcgc cagcaactgc 3060 atctcccgcc gtgcacaggg tgtcacgttg caagacctgc ctgaaaccga actgcccgct 3120 gttctgcagc cggtcgcgga ggccatggat gcgatcgctg cggccgatct tagccagacg 3180 agcgggttcg gcccattcgg accgcaagga atcggtcaat acactacatg gcgtgatttc 3240 atatgcgcga ttgctgatcc ccatgtgtat cactggcaaa ctgtgatgga cgacaccgtc 3300 agtgcgtccg tcgcgcaggc tctcgatgag ctgatgcttt gggccgagga ctgccccgaa 3360 gtccggcacc tcgtgcacgc ggatttcggc tccaacaatg tcctgacgga caatggccgc 3420 ataacagcgg tcattgactg gagcgaggcg atgttcgggg attcccaata cgaggtcgcc 3480 aacatcttct tctggaggcc gtggttggct tgtatggagc agcagacgcg ctacttcgag 3540 cggaggcatc cggagcttgc aggatcgccg cggctccggg cgtatatgct ccgcattggt 3600 cttgaccaac tctatcagag cttggttgac ggcaatttcg atgatgcagc ttgggcgcag 3660 ggtcgatgcg acgcaatcgt ccgatccgga gccgggactg tcgggcgtac acaaatcgcc 3720 cgcagaagcg cggccgtctg gaccgatggc tgtgtagaag tactcgccga tagtggaaac 3780 cgacgcccca gcactcgtcc gagggcaaag gaatagcacc ggtggcgcgt taagtcgaca 3840 atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc 3900 cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta 3960 tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt 4020 ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg 4080 gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta 4140 ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt 4200 tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg 4260 cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca 4320 atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc 4380 gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgcgt cgactttaag 4440 accaatgact tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact 4500 ggaagggcta attcactccc aacgaagaca agatctgctt tttgcttgta ctgggtctct 4560 ctggttagac cagatctgag cctgggagct ctctggctaa ctagggaacc cactgcttaa 4620 gcctcaataa agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc 4680 tggtaactag agatccctca gaccctttta gtcagtgtgg aaaatctcta gcagtacgta 4740 tagtagttca tgtcatctta ttattcagta tttataactt gcaaagaaat gaatatcaga 4800 gagtgagagg aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac 4860 aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat 4920 caatgtatct tatcatgtct ggctctagct atcccgcccc taactccgcc catcccgccc 4980 ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat 5040 gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg aggctttttt 5100 ggaggcctag ggacgtaccc aattcgccct atagtgagtc gtattacgcg cgctcactgg 5160 ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 5220 cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 5280 cccaacagtt gcgcagcctg aatggcgaat gggacgcgcc ctgtagcggc gcattaagcg 5340 cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg 5400 ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc 5460 taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa 5520 aacttgatta gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc 5580 ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac 5640 tcaaccctat ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt 5700 ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa atattaacgc 5760 ttacaattta ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt 5820 ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata 5880 atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt 5940 tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc 6000 tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat 6060 ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct 6120 atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc gccgcataca 6180 ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg 6240 catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa 6300 cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg 6360 ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga 6420 cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg 6480 cgaactactt actctagctt cccggcaaca attaatagac tggatggagg cggataaagt 6540 tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg 6600 agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc 6660 ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca 6720 gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc 6780 atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat 6840 cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc 6900 agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg 6960 ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct 7020 accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa atactgttct 7080 tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct 7140 cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg 7200 gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc 7260 gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga 7320 gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg 7380 cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta 7440 tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg 7500 ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg 7560 ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat 7620 taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc 7680 agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg cgcgttggcc 7740 gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa 7800 cgcaattaat gtgagttagc tcactcatta ggcaccccag gctttacact ttatgcttcc 7860 ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa acagctatga 7920 ccatgattac gccaagcgcg caattaaccc tcactaaagg gaacaaaagc tggagctgca 7980 agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag 8040 caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg 8100 tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact 8160 gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacat aaacgggtct 8220 ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt 8280 aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac 8340 tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc 8400 gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc 8460 ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa 8520 ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg 8580 ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata 8640 aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc 8700 tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga 8760 caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc 8820 aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca 8880 aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg 8940 agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga 9000 gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata 9060 ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg 9120 acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg 9180 ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag 9240 ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt 9300 tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt 9360 aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt 9420 aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag 9480 aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata 9540 acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta 9600 agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta 9660 tcgtttcaga cccacctccc aaccccgagg ggacccttgc gccttttcca aggcagccct 9720 gggtttgcgc agggacgcgg ctgctctggg cgtggttccg ggaaacgcag cggcgccgac 9780 cctgggtctc gcacattctt cacgtccgtt cgcagcgtca cccggatctt cgccgctacc 9840 cttgtgggcc ccccggcgac gcttcctgct ccgcccctaa gtcgggaagg ttccttgcgg 9900 ttcgcggcgt gccggacgtg acaaacggaa gccgcacgtc tcactagtac cctcgcagac 9960 ggacagcgcc agggagcaat ggcagcgcgc cgaccgcgat gggctgtggc caatagcggc 10020 tgctcagcag ggcgcgccga gagcagcggc cgggaagggg cggtgcggga ggcggggtgt 10080 ggggcggtag tgtgggccct gttcctgccc gcgcggtgtt ccgcattctg caagcctccg 10140 gagcgcacgt cggcagtcgg ctccctcgtt gaccgaatca ccgacctctc tccccagggg 10200 gtacccagct gtctagagaa ttctagatct tgagacaaat ggcagtattc atccacaatt 10260 ttaaaagaaa aggggggatt ggggggtaca gtgcagggga aagaatagta gacataatag 10320 caacagacat acaaactaaa gaattacaaa aacaaattac aaaaattcaa aattttcggg 10380 tttattacag ggacagcaga gatccacttt ggcgccggct cgaggggg 10428 <210> 105 <211> 290 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 105 Met Ala Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn 1 5 10 15 Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn 20 25 30 Gly Phe Ile Ala Ser Asn Cys Ile Ser Arg Arg Ala Gln Gly Val Thr 35 40 45 Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu Gln Pro Val 50 55 60 Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser Gln Thr Ser 65 70 75 80 Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr Thr Thr Trp 85 90 95 Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr His Trp Gln 100 105 110 Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln Ala Leu Asp 115 120 125 Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg His Leu Val 130 135 140 His Ala Asp Phe Gly Ser Asn Asn Val Leu Thr Asp Asn Gly Arg Ile 145 150 155 160 Thr Ala Val Ile Asp Trp Ser Glu Ala Met Phe Gly Asp Ser Gln Tyr 165 170 175 Glu Val Ala Asn Ile Phe Phe Trp Arg Pro Trp Leu Ala Cys Met Glu 180 185 190 Gln Gln Thr Arg Tyr Phe Glu Arg Arg His Pro Glu Leu Ala Gly Ser 195 200 205 Pro Arg Leu Arg Ala Tyr Met Leu Arg Ile Gly Leu Asp Gln Leu Tyr 210 215 220 Gln Ser Leu Val Asp Gly Asn Phe Asp Asp Ala Ala Trp Ala Gln Gly 225 230 235 240 Arg Cys Asp Ala Ile Val Arg Ser Gly Ala Gly Thr Val Gly Arg Thr 245 250 255 Gln Ile Ala Arg Arg Ser Ala Ala Val Trp Thr Asp Gly Cys Val Glu 260 265 270 Val Leu Ala Asp Ser Gly Asn Arg Arg Pro Ser Thr Arg Pro Arg Ala 275 280 285 Lys Glu 290 <210> 106 <211> 9222 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 106 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgagcga gctgattaag 660 gagaacatgc acatgaagct gtacatggag ggcaccgtgg acaaccatca cttcaagtgc 720 acatccgagg gcgaaggcaa gccctacgag ggcacccaga ccatgagaat caaggtggtc 780 gagggcggcc ctctcccctt cgccttcgac atcctggcta ctagcttcct ctacggcagc 840 aagaccttca tcaaccacac ccagggcatc cccgacttct tcaagcagtc cttccctgag 900 ggcttcacat gggagagagt caccacatac gaagacgggg gcgtgctgac cgctacccag 960 gacaccagcc tccaggacgg ctgcctcatc tacaacgtca agatcagagg ggtgaacttc 1020 acatccaacg gccctgtgat gcagaagaaa acactcggct gggaggcctt caccgagacg 1080 ctgtaccccg ctgacggcgg cctggaaggc agaaacgaca tggccctgaa gctcgtgggc 1140 gggagccatc tgatcgcaaa catcaagacc acatatagat ccaagaaacc cgctaagaac 1200 ctcaagatgc ctggcgtcta ctatgtggac tacagactgg aaagaatcaa ggaggccaac 1260 aacgagacct acgtcgagca gcacgaggtg gcagtggcca gatactgcga cctccctagc 1320 aaactggggc acaagcttaa ttaattaatt aagaattcga cccagctttc ttgtacaaag 1380 tggttggtaa gcctatccct aaccctctcc tcggtctcga ttctacgtag taatgagcta 1440 gcagtctcga ggttaacgaa ttccgccccc cccctaacgt tactggccga agccgcttgg 1500 aataaggccg gtgtgcgctt gtctatatgt tattttccac catattgccg tcttttggca 1560 atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg ggtctttccc 1620 ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt cctctggaag 1680 cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac cccccacctg 1740 gcgacaggtg cccctgcggc caaaagccac gtgtataaga tacacctgca aaggcggcac 1800 aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg ctctcctcaa 1860 gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg ggatctgatc 1920 tggggcctcg gtgcacatgc tttacatgtg tttagtcgag gttaaaaaaa cgtctaggcc 1980 ccccgaacca cggggacgtg gttttccttt gaaaaacacg ataataccat ggccatgaaa 2040 aagcctgaac tcaccgcgac gtctgtcgag aagtttctga tcgaaaagtt cgacagcgtc 2100 tccgacctga tgcagctctc ggagggcgaa gaatctcgtg ctttcagctt cgatgtagga 2160 gggcgtggat atgtcctgcg ggtaaatagc tgcgccgatg gtttctacaa agatcgttat 2220 gtttatcggc actttgcatc ggccgcgctc ccgattccgg aagtgcttga cattggggaa 2280 tttagcgaga gcctgaccta ttgcctttca tacgagaccg agatcctgac tgtcgagtac 2340 ggattgcttc ctatcggcaa aatcgtggag aagaggattg aatgtaccgt ctattcagtc 2400 gataataatg ggaacatcta cacacagccc gtggctcaat ggcacgacag aggagagcag 2460 gaagtttttg aatactgtct cgaggacgga tccctcatcc gcgctactaa agatcataag 2520 tttatgaccg tggacggcca gatgctgcca attgacgaaa tttttgaacg agagctggat 2580 ctgatgagag tcgacaacct tccaaactga caccggtggc gcgttaagtc gacaatcaac 2640 ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta 2700 cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt 2760 tcattttctc ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg 2820 ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg 2880 gcattgccac cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca 2940 cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca 3000 ctgacaattc cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg 3060 ttgccacctg gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag 3120 cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc 3180 gccctcagac gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat 3240 gacttacaag gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg 3300 gctaattcac tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt 3360 agaccagatc tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca 3420 ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa 3480 ctagagatcc ctcagaccct tttagtcagt gtggaaaatc tctagcagta cgtatagtag 3540 ttcatgtcat cttattattc agtatttata acttgcaaag aaatgaatat cagagagtga 3600 gaggaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 3660 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 3720 atcttatcat gtctggctct agctatcccg cccctaactc cgcccatccc gcccctaact 3780 ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag 3840 gccgaggccg cctcggcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc 3900 ctagggacgt acccaattcg ccctatagtg agtcgtatta cgcgcgctca ctggccgtcg 3960 ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc cttgcagcac 4020 atcccccttt cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac 4080 agttgcgcag cctgaatggc gaatgggacg cgccctgtag cggcgcatta agcgcggcgg 4140 gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt 4200 tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc 4260 gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg 4320 attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga 4380 cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc 4440 ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa 4500 aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta acgcttacaa 4560 tttaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat 4620 acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg 4680 aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc 4740 attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga 4800 tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga 4860 gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg 4920 cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc 4980 tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac 5040 agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact 5100 tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca 5160 tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg 5220 tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact 5280 acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg 5340 accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg 5400 tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat 5460 cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc 5520 tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat 5580 actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt 5640 tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc 5700 cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt 5760 gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac 5820 tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt 5880 gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct 5940 gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga 6000 ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac 6060 acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg 6120 agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt 6180 cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc 6240 tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg 6300 gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc 6360 ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc 6420 ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag 6480 cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca 6540 ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc gcaacgcaat 6600 taatgtgagt tagctcactc attaggcacc ccaggcttta cactttatgc ttccggctcg 6660 tatgttgtgt ggaattgtga gcggataaca atttcacaca ggaaacagct atgaccatga 6720 ttacgccaag cgcgcaatta accctcacta aagggaacaa aagctggagc tgcaagctta 6780 atgtagtctt atgcaatact cttgtagtct tgcaacatgg taacgatgag ttagcaacat 6840 gccttacaag gagagaaaaa gcaccgtgca tgccgattgg tggaagtaag gtggtacgat 6900 cgtgccttat taggaaggca acagacgggt ctgacatgga ttggacgaac cactgaattg 6960 ccgcattgca gagatattgt atttaagtgc ctagctcgat acataaacgg gtctctctgg 7020 ttagaccaga tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct 7080 caataaagct tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt 7140 aactagagat ccctcagacc cttttagtca gtgtggaaaa tctctagcag tggcgcccga 7200 acagggactt gaaagcgaaa gggaaaccag aggagctctc tcgacgcagg actcggcttg 7260 ctgaagcgcg cacggcaaga ggcgaggggc ggcgactggt gagtacgcca aaaattttga 7320 ctagcggagg ctagaaggag agagatgggt gcgagagcgt cagtattaag cgggggagaa 7380 ttagatcgcg atgggaaaaa attcggttaa ggccaggggg aaagaaaaaa tataaattaa 7440 aacatatagt atgggcaagc agggagctag aacgattcgc agttaatcct ggcctgttag 7500 aaacatcaga aggctgtaga caaatactgg gacagctaca accatccctt cagacaggat 7560 cagaagaact tagatcatta tataatacag tagcaaccct ctattgtgtg catcaaagga 7620 tagagataaa agacaccaag gaagctttag acaagataga ggaagagcaa aacaaaagta 7680 agaccaccgc acagcaagcg gccgctgatc ttcagacctg gaggaggaga tatgagggac 7740 aattggagaa gtgaattata taaatataaa gtagtaaaaa ttgaaccatt aggagtagca 7800 cccaccaagg caaagagaag agtggtgcag agagaaaaaa gagcagtggg aataggagct 7860 ttgttccttg ggttcttggg agcagcagga agcactatgg gcgcagcgtc aatgacgctg 7920 acggtacagg ccagacaatt attgtctggt atagtgcagc agcagaacaa tttgctgagg 7980 gctattgagg cgcaacagca tctgttgcaa ctcacagtct ggggcatcaa gcagctccag 8040 gcaagaatcc tggctgtgga aagataccta aaggatcaac agctcctggg gatttggggt 8100 tgctctggaa aactcatttg caccactgct gtgccttgga atgctagttg gagtaataaa 8160 tctctggaac agatttggaa tcacacgacc tggatggagt gggacagaga aattaacaat 8220 tacacaagct taatacactc cttaattgaa gaatcgcaaa accagcaaga aaagaatgaa 8280 caagaattat tggaattaga taaatgggca agtttgtgga attggtttaa cataacaaat 8340 tggctgtggt atataaaatt attcataatg atagtaggag gcttggtagg tttaagaata 8400 gtttttgctg tactttctat agtgaataga gttaggcagg gatattcacc attatcgttt 8460 cagacccacc tcccaacccc gaggggaccc ttgcgccttt tccaaggcag ccctgggttt 8520 gcgcagggac gcggctgctc tgggcgtggt tccgggaaac gcagcggcgc cgaccctggg 8580 tctcgcacat tcttcacgtc cgttcgcagc gtcacccgga tcttcgccgc tacccttgtg 8640 ggccccccgg cgacgcttcc tgctccgccc ctaagtcggg aaggttcctt gcggttcgcg 8700 gcgtgccgga cgtgacaaac ggaagccgca cgtctcacta gtaccctcgc agacggacag 8760 cgccagggag caatggcagc gcgccgaccg cgatgggctg tggccaatag cggctgctca 8820 gcagggcgcg ccgagagcag cggccgggaa ggggcggtgc gggaggcggg gtgtggggcg 8880 gtagtgtggg ccctgttcct gcccgcgcgg tgttccgcat tctgcaagcc tccggagcgc 8940 acgtcggcag tcggctccct cgttgaccga atcaccgacc tctctcccca gggggtaccc 9000 agctgtctag agaattctag atcttgagac aaatggcagt attcatccac aattttaaaa 9060 gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata atagcaacag 9120 acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt cgggtttatt 9180 acagggacag cagagatcca ctttggcgcc ggctcgaggg gg 9222 <210> 107 <211> 9522 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 107 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggtgag caagggcgag 660 gaggataaca tggccatcat caaggagttc atgcgcttca aggtgcacat ggagggctcc 720 gtgaacggcc acgagttcga gatcgagggc gagggcgagg gccgccccta cgagggcacc 780 cagaccgcca agctgaaggt gaccaagggt ggccccctgc ccttcgcctg ggacatcctg 840 tcccctcagt tcatgtacgg ctccaaggcc tacgtgaagc accccgccga catccccgac 900 tacttgaagc tgtccttccc cgagggcttc aagtgggagc gcgtgatgaa cttcgaggac 960 ggcggcgtgg tgaccgtgac ccaggactcc tccctgcagg acggcgagtt catctacaag 1020 gtgaagctgc gcggcaccaa cttcccctcc gacggccccg taatgcagaa gaagaccatg 1080 ggctgggagg cctcctccga gcggatgtac cccgaggacg gcgccctgaa gggcgagatc 1140 aagcagaggc tgaagctgaa ggacggcggc cactacgacg ctgaggtcaa gaccacctac 1200 aaggccaaga agcccgtgca gctgcccggc gcctacaacg tcaacattaa gttggacatc 1260 acctcccaca acgaggacta caccatcgtg gaacagtacg aacgcgccga gggccgccac 1320 tccaccggcg gcatggacga gctgtacaag tgattaatta agaattcgac ccagctttct 1380 tgtacaaagt ggttggtaag cctatcccta accctctcct cggtctcgat tctacgtagt 1440 aatgagctag cagtctcgag gttaacgaat tccgcccccc ccctaacgtt actggccgaa 1500 gccgcttgga ataaggccgg tgtgcgcttg tctatatgtt attttccacc atattgccgt 1560 cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg 1620 gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc 1680 ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc 1740 ccccacctgg cgacaggtgc ccctgcggcc aaaagccacg tgtataagat acacctgcaa 1800 aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc 1860 tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg 1920 gatctgatct ggggcctcgg tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaaac 1980 gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga taataccatg 2040 gccatgatta agatcgctac gcggaagtac ctggggaaac agaacgtcta cgacataggt 2100 gtggagcgcg atcacaactt tgctctgaaa aatggattta tcgccagcaa ctgcatctcc 2160 cgccgtgcac agggtgtcac gttgcaagac ctgcctgaaa ccgaactgcc cgctgttctg 2220 cagccggtcg cggaggccat ggatgcgatc gctgcggccg atcttagcca gacgagcggg 2280 ttcggcccat tcggaccgca aggaatcggt caatacacta catggcgtga tttcatatgc 2340 gcgattgctg atccccatgt gtatcactgg caaactgtga tggacgacac cgtcagtgcg 2400 tccgtcgcgc aggctctcga tgagctgatg ctttgggccg aggactgccc cgaagtccgg 2460 cacctcgtgc acgcggattt cggctccaac aatgtcctga cggacaatgg ccgcataaca 2520 gcggtcattg actggagcga ggcgatgttc ggggattccc aatacgaggt cgccaacatc 2580 ttcttctgga ggccgtggtt ggcttgtatg gagcagcaga cgcgctactt cgagcggagg 2640 catccggagc ttgcaggatc gccgcggctc cgggcgtata tgctccgcat tggtcttgac 2700 caactctatc agagcttggt tgacggcaat ttcgatgatg cagcttgggc gcagggtcga 2760 tgcgacgcaa tcgtccgatc cggagccggg actgtcgggc gtacacaaat cgcccgcaga 2820 agcgcggccg tctggaccga tggctgtgta gaagtactcg ccgatagtgg aaaccgacgc 2880 cccagcactc gtccgagggc aaaggaatag caccggtggc gcgttaagtc gacaatcaac 2940 ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta 3000 cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt 3060 tcattttctc ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg 3120 ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg 3180 gcattgccac cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca 3240 cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca 3300 ctgacaattc cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg 3360 ttgccacctg gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag 3420 cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc 3480 gccctcagac gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat 3540 gacttacaag gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg 3600 gctaattcac tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt 3660 agaccagatc tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca 3720 ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa 3780 ctagagatcc ctcagaccct tttagtcagt gtggaaaatc tctagcagta cgtatagtag 3840 ttcatgtcat cttattattc agtatttata acttgcaaag aaatgaatat cagagagtga 3900 gaggaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 3960 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 4020 atcttatcat gtctggctct agctatcccg cccctaactc cgcccatccc gcccctaact 4080 ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag 4140 gccgaggccg cctcggcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc 4200 ctagggacgt acccaattcg ccctatagtg agtcgtatta cgcgcgctca ctggccgtcg 4260 ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc cttgcagcac 4320 atcccccttt cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac 4380 agttgcgcag cctgaatggc gaatgggacg cgccctgtag cggcgcatta agcgcggcgg 4440 gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt 4500 tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc 4560 gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg 4620 attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga 4680 cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc 4740 ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa 4800 aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta acgcttacaa 4860 tttaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat 4920 acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg 4980 aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc 5040 attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga 5100 tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga 5160 gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg 5220 cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc 5280 tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac 5340 agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact 5400 tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca 5460 tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg 5520 tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact 5580 acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg 5640 accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg 5700 tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat 5760 cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc 5820 tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat 5880 actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt 5940 tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc 6000 cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt 6060 gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac 6120 tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt 6180 gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct 6240 gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga 6300 ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac 6360 acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg 6420 agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt 6480 cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc 6540 tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg 6600 gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc 6660 ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc 6720 ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag 6780 cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca 6840 ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc gcaacgcaat 6900 taatgtgagt tagctcactc attaggcacc ccaggcttta cactttatgc ttccggctcg 6960 tatgttgtgt ggaattgtga gcggataaca atttcacaca ggaaacagct atgaccatga 7020 ttacgccaag cgcgcaatta accctcacta aagggaacaa aagctggagc tgcaagctta 7080 atgtagtctt atgcaatact cttgtagtct tgcaacatgg taacgatgag ttagcaacat 7140 gccttacaag gagagaaaaa gcaccgtgca tgccgattgg tggaagtaag gtggtacgat 7200 cgtgccttat taggaaggca acagacgggt ctgacatgga ttggacgaac cactgaattg 7260 ccgcattgca gagatattgt atttaagtgc ctagctcgat acataaacgg gtctctctgg 7320 ttagaccaga tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct 7380 caataaagct tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt 7440 aactagagat ccctcagacc cttttagtca gtgtggaaaa tctctagcag tggcgcccga 7500 acagggactt gaaagcgaaa gggaaaccag aggagctctc tcgacgcagg actcggcttg 7560 ctgaagcgcg cacggcaaga ggcgaggggc ggcgactggt gagtacgcca aaaattttga 7620 ctagcggagg ctagaaggag agagatgggt gcgagagcgt cagtattaag cgggggagaa 7680 ttagatcgcg atgggaaaaa attcggttaa ggccaggggg aaagaaaaaa tataaattaa 7740 aacatatagt atgggcaagc agggagctag aacgattcgc agttaatcct ggcctgttag 7800 aaacatcaga aggctgtaga caaatactgg gacagctaca accatccctt cagacaggat 7860 cagaagaact tagatcatta tataatacag tagcaaccct ctattgtgtg catcaaagga 7920 tagagataaa agacaccaag gaagctttag acaagataga ggaagagcaa aacaaaagta 7980 agaccaccgc acagcaagcg gccgctgatc ttcagacctg gaggaggaga tatgagggac 8040 aattggagaa gtgaattata taaatataaa gtagtaaaaa ttgaaccatt aggagtagca 8100 cccaccaagg caaagagaag agtggtgcag agagaaaaaa gagcagtggg aataggagct 8160 ttgttccttg ggttcttggg agcagcagga agcactatgg gcgcagcgtc aatgacgctg 8220 acggtacagg ccagacaatt attgtctggt atagtgcagc agcagaacaa tttgctgagg 8280 gctattgagg cgcaacagca tctgttgcaa ctcacagtct ggggcatcaa gcagctccag 8340 gcaagaatcc tggctgtgga aagataccta aaggatcaac agctcctggg gatttggggt 8400 tgctctggaa aactcatttg caccactgct gtgccttgga atgctagttg gagtaataaa 8460 tctctggaac agatttggaa tcacacgacc tggatggagt gggacagaga aattaacaat 8520 tacacaagct taatacactc cttaattgaa gaatcgcaaa accagcaaga aaagaatgaa 8580 caagaattat tggaattaga taaatgggca agtttgtgga attggtttaa cataacaaat 8640 tggctgtggt atataaaatt attcataatg atagtaggag gcttggtagg tttaagaata 8700 gtttttgctg tactttctat agtgaataga gttaggcagg gatattcacc attatcgttt 8760 cagacccacc tcccaacccc gaggggaccc ttgcgccttt tccaaggcag ccctgggttt 8820 gcgcagggac gcggctgctc tgggcgtggt tccgggaaac gcagcggcgc cgaccctggg 8880 tctcgcacat tcttcacgtc cgttcgcagc gtcacccgga tcttcgccgc tacccttgtg 8940 ggccccccgg cgacgcttcc tgctccgccc ctaagtcggg aaggttcctt gcggttcgcg 9000 gcgtgccgga cgtgacaaac ggaagccgca cgtctcacta gtaccctcgc agacggacag 9060 cgccagggag caatggcagc gcgccgaccg cgatgggctg tggccaatag cggctgctca 9120 gcagggcgcg ccgagagcag cggccgggaa ggggcggtgc gggaggcggg gtgtggggcg 9180 gtagtgtggg ccctgttcct gcccgcgcgg tgttccgcat tctgcaagcc tccggagcgc 9240 acgtcggcag tcggctccct cgttgaccga atcaccgacc tctctcccca gggggtaccc 9300 agctgtctag agaattctag atcttgagac aaatggcagt attcatccac aattttaaaa 9360 gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata atagcaacag 9420 acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt cgggtttatt 9480 acagggacag cagagatcca ctttggcgcc ggctcgaggg gg 9522 <210> 108 <211> 10232 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 108 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagctgaacg agaaacgtaa aatgatataa atatcaatat attaaattag 660 attttgcata aaaaacagac tacataatac tgtaaaacac aacatatcca gtcactatgg 720 cggccgcatt aggcacccca ggctttacac tttatgcttc cggctcgtat aatgtgtgga 780 ttttgagtta ggatccgtcg agattttcag gagctaagga agctaaaatg gagaaaaaaa 840 tcactggata taccaccgtt gatatatccc aatggcatcg taaagaacat tttgaggcat 900 ttcagtcagt tgctcaatgt acctataacc agaccgttca gctggatatt acggcctttt 960 taaagaccgt aaagaaaaat aagcacaagt tttatccggc ctttattcac attcttgccc 1020 gcctgatgaa tgctcatccg gaattccgta tggcaatgaa agacggtgag ctggtgatat 1080 gggatagtgt tcacccttgt tacaccgttt tccatgagca aactgaaacg ttttcatcgc 1140 tctggagtga ataccacgac gatttccggc agtttctaca catatattcg caagatgtgg 1200 cgtgttacgg tgaaaacctg gcctatttcc ctaaagggtt tattgagaat atgtttttcg 1260 tctcagccaa tccctgggtg agtttcacca gttttgattt aaacgtggcc aatatggaca 1320 acttcttcgc ccccgttttc accatgggca aatattatac gcaaggcgac aaggtgctga 1380 tgccgctggc gattcaggtt catcatgccg tttgtgatgg cttccatgtc ggcagaatgc 1440 ttaatgaatt acaacagtac tgcgatgagt ggcagggcgg ggcgtaaaga tctggatccg 1500 gcttactaaa agccagataa cagtatgcgt atttgcgcgc tgatttttgc ggtataagaa 1560 tatatactga tatgtatacc cgaagtatgt caaaaagagg tatgctatga agcagcgtat 1620 tacagtgaca gttgacagcg acagctatca gttgctcaag gcatatatga tgtcaatatc 1680 tccggtctgg taagcacaac catgcagaat gaagcccgtc gtctgcgtgc cgaacgctgg 1740 aaagcggaaa atcaggaagg gatggctgag gtcgcccggt ttattgaaat gaacggctct 1800 tttgctgacg agaacagggg ctggtgaaat gcagtttaag gtttacacct ataaaagaga 1860 gagccgttat cgtctgtttg tggatgtaca gagtgatatt attgacacgc ccgggcgacg 1920 gatggtgatc cccctggcca gtgcacgtct gctgtcagat aaagtctccc gtgaacttta 1980 cccggtggtg catatcgggg atgaaagctg gcgcatgatg accaccgata tggccagtgt 2040 gccggtctcc gttatcgggg aagaagtggc tgatctcagc caccgcgaaa atgacatcaa 2100 aaacgccatt aacctgatgt tctggggaat ataaatgtca ggctccctta tacacagcca 2160 gtctgcaggt cgaccatagt gactggatat gttgtgtttt acagtattat gtagtctgtt 2220 ttttatgcaa aatctaattt aatatattga tatttatatc attttacgtt tctcgttcag 2280 ctttcttgta caaagtggtt ggtaagccta tccctaaccc tctcctcggt ctcgattcta 2340 cgtagtaatg agctagcagt ctcgaggtta acgaattccg ccccccccct aacgttactg 2400 gccgaagccg cttggaataa ggccggtgtg cgcttgtcta tatgttattt tccaccatat 2460 tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc 2520 ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag 2580 cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc 2640 ggaacccccc acctggcgac aggtgcccct gcggccaaaa gccacgtgta taagatacac 2700 ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca 2760 aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt 2820 gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa 2880 aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgataat 2940 accatggcca tgaccgagta caagcccacg gtgcgcctcg ccacccgcga cgacgtcccc 3000 agggccgtac gcaccctcgc cgccgcgttc gccgactacc ccgccacgcg ccacaccgtc 3060 gatccggacc gccacatcga gcgggtcacc gagctgcaag aactcttcct cacgcgcgtc 3120 gggctcgaca tcggcaaggt gtgggtcgcg gacgacggcg ccgcggtggc ggtctggacc 3180 acgccggaga gcgtcgaagc gggggcggtg ttcgccgaga tcggcccgcg catggccgag 3240 ttgagcggtt cccggctggc cgcgcagcaa cagatggaag gcctcctggc gccgcaccgg 3300 cccaagtgcc tttcatacga gaccgagatc ctgactgtcg agtacggatt gcttcctatc 3360 ggcaaaatcg tggagaagag gattgaatgt accgtctatt cagtcgataa taatgggaac 3420 atctacacac agcccgtggc tcaatggcac gacagaggag agcaggaagt ttttgaatac 3480 tgtctcgagg acggatccct catccgcgct actaaagatc ataagtttat gaccgtggac 3540 ggccagatgc tgccaattga cgaaattttt gaacgagagc tggatctgat gagagtcgac 3600 aaccttccaa actgagaatt caccggtggc gcgttaagtc gacaatcaac ctctggatta 3660 caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg 3720 atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc 3780 ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca 3840 acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac 3900 cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact 3960 catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc 4020 cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg ttgccacctg 4080 gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc 4140 ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac 4200 gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat gacttacaag 4260 gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac 4320 tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt agaccagatc 4380 tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg 4440 ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc 4500 ctcagaccct tttagtcagt gtggaaaatc tctagcagta cgtatagtag ttcatgtcat 4560 cttattattc agtatttata acttgcaaag aaatgaatat cagagagtga gaggaacttg 4620 tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa 4680 gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat 4740 gtctggctct agctatcccg cccctaactc cgcccatccc gcccctaact ccgcccagtt 4800 ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag gccgaggccg 4860 cctcggcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc ctagggacgt 4920 acccaattcg ccctatagtg agtcgtatta cgcgcgctca ctggccgtcg ttttacaacg 4980 tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc cttgcagcac atcccccttt 5040 cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac agttgcgcag 5100 cctgaatggc gaatgggacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt 5160 tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt 5220 cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc gggggctccc 5280 tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg attagggtga 5340 tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga cgttggagtc 5400 cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc ctatctcggt 5460 ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa aaaatgagct 5520 gatttaacaa aaatttaacg cgaattttaa caaaatatta acgcttacaa tttaggtggc 5580 acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat 5640 atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag 5700 agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt 5760 cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt 5820 gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga gagttttcgc 5880 cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta 5940 tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac 6000 ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa 6060 ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg 6120 atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc 6180 cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg 6240 atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta 6300 gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg accacttctg 6360 cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg 6420 tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc 6480 tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt 6540 gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt 6600 gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc 6660 atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag 6720 atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa 6780 aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg 6840 aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt gtagccgtag 6900 ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg 6960 ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga 7020 tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc 7080 ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc 7140 acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga 7200 gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt 7260 cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg 7320 aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac 7380 atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc ctttgagtga 7440 gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg 7500 gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca ttaatgcagc 7560 tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt 7620 tagctcactc attaggcacc ccaggcttta cactttatgc ttccggctcg tatgttgtgt 7680 ggaattgtga gcggataaca atttcacaca ggaaacagct atgaccatga ttacgccaag 7740 cgcgcaatta accctcacta aagggaacaa aagctggagc tgcaagctta atgtagtctt 7800 atgcaatact cttgtagtct tgcaacatgg taacgatgag ttagcaacat gccttacaag 7860 gagagaaaaa gcaccgtgca tgccgattgg tggaagtaag gtggtacgat cgtgccttat 7920 taggaaggca acagacgggt ctgacatgga ttggacgaac cactgaattg ccgcattgca 7980 gagatattgt atttaagtgc ctagctcgat acataaacgg gtctctctgg ttagaccaga 8040 tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct 8100 tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat 8160 ccctcagacc cttttagtca gtgtggaaaa tctctagcag tggcgcccga acagggactt 8220 gaaagcgaaa gggaaaccag aggagctctc tcgacgcagg actcggcttg ctgaagcgcg 8280 cacggcaaga ggcgaggggc ggcgactggt gagtacgcca aaaattttga ctagcggagg 8340 ctagaaggag agagatgggt gcgagagcgt cagtattaag cgggggagaa ttagatcgcg 8400 atgggaaaaa attcggttaa ggccaggggg aaagaaaaaa tataaattaa aacatatagt 8460 atgggcaagc agggagctag aacgattcgc agttaatcct ggcctgttag aaacatcaga 8520 aggctgtaga caaatactgg gacagctaca accatccctt cagacaggat cagaagaact 8580 tagatcatta tataatacag tagcaaccct ctattgtgtg catcaaagga tagagataaa 8640 agacaccaag gaagctttag acaagataga ggaagagcaa aacaaaagta agaccaccgc 8700 acagcaagcg gccgctgatc ttcagacctg gaggaggaga tatgagggac aattggagaa 8760 gtgaattata taaatataaa gtagtaaaaa ttgaaccatt aggagtagca cccaccaagg 8820 caaagagaag agtggtgcag agagaaaaaa gagcagtggg aataggagct ttgttccttg 8880 ggttcttggg agcagcagga agcactatgg gcgcagcgtc aatgacgctg acggtacagg 8940 ccagacaatt attgtctggt atagtgcagc agcagaacaa tttgctgagg gctattgagg 9000 cgcaacagca tctgttgcaa ctcacagtct ggggcatcaa gcagctccag gcaagaatcc 9060 tggctgtgga aagataccta aaggatcaac agctcctggg gatttggggt tgctctggaa 9120 aactcatttg caccactgct gtgccttgga atgctagttg gagtaataaa tctctggaac 9180 agatttggaa tcacacgacc tggatggagt gggacagaga aattaacaat tacacaagct 9240 taatacactc cttaattgaa gaatcgcaaa accagcaaga aaagaatgaa caagaattat 9300 tggaattaga taaatgggca agtttgtgga attggtttaa cataacaaat tggctgtggt 9360 atataaaatt attcataatg atagtaggag gcttggtagg tttaagaata gtttttgctg 9420 tactttctat agtgaataga gttaggcagg gatattcacc attatcgttt cagacccacc 9480 tcccaacccc gaggggaccc ttgcgccttt tccaaggcag ccctgggttt gcgcagggac 9540 gcggctgctc tgggcgtggt tccgggaaac gcagcggcgc cgaccctggg tctcgcacat 9600 tcttcacgtc cgttcgcagc gtcacccgga tcttcgccgc tacccttgtg ggccccccgg 9660 cgacgcttcc tgctccgccc ctaagtcggg aaggttcctt gcggttcgcg gcgtgccgga 9720 cgtgacaaac ggaagccgca cgtctcacta gtaccctcgc agacggacag cgccagggag 9780 caatggcagc gcgccgaccg cgatgggctg tggccaatag cggctgctca gcagggcgcg 9840 ccgagagcag cggccgggaa ggggcggtgc gggaggcggg gtgtggggcg gtagtgtggg 9900 ccctgttcct gcccgcgcgg tgttccgcat tctgcaagcc tccggagcgc acgtcggcag 9960 tcggctccct cgttgaccga atcaccgacc tctctcccca gggggtaccc agctgtctag 10020 agaattctag atcttgagac aaatggcagt attcatccac aattttaaaa gaaaaggggg 10080 gattgggggg tacagtgcag gggaaagaat agtagacata atagcaacag acatacaaac 10140 taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt cgggtttatt acagggacag 10200 cagagatcca ctttggcgcc ggctcgaggg gg 10232 <210> 109 <211> 223 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 109 Met Ala Met Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp 1 5 10 15 Asp Val Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr 20 25 30 Pro Ala Thr Arg His Thr Val Asp Pro Asp Arg His Ile Glu Arg Val 35 40 45 Thr Glu Leu Gln Glu Leu Phe Leu Thr Arg Val Gly Leu Asp Ile Gly 50 55 60 Lys Val Trp Val Ala Asp Asp Gly Ala Ala Val Ala Val Trp Thr Thr 65 70 75 80 Pro Glu Ser Val Glu Ala Gly Ala Val Phe Ala Glu Ile Gly Pro Arg 85 90 95 Met Ala Glu Leu Ser Gly Ser Arg Leu Ala Ala Gln Gln Gln Met Glu 100 105 110 Gly Leu Leu Ala Pro His Arg Pro Lys Cys Leu Ser Tyr Glu Thr Glu 115 120 125 Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu 130 135 140 Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile 145 150 155 160 Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val 165 170 175 Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp 180 185 190 His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile 195 200 205 Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn 210 215 220 <210> 110 <211> 9920 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 110 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagctgaacg agaaacgtaa aatgatataa atatcaatat attaaattag 660 attttgcata aaaaacagac tacataatac tgtaaaacac aacatatcca gtcactatgg 720 cggccgcatt aggcacccca ggctttacac tttatgcttc cggctcgtat aatgtgtgga 780 ttttgagtta ggatccgtcg agattttcag gagctaagga agctaaaatg gagaaaaaaa 840 tcactggata taccaccgtt gatatatccc aatggcatcg taaagaacat tttgaggcat 900 ttcagtcagt tgctcaatgt acctataacc agaccgttca gctggatatt acggcctttt 960 taaagaccgt aaagaaaaat aagcacaagt tttatccggc ctttattcac attcttgccc 1020 gcctgatgaa tgctcatccg gaattccgta tggcaatgaa agacggtgag ctggtgatat 1080 gggatagtgt tcacccttgt tacaccgttt tccatgagca aactgaaacg ttttcatcgc 1140 tctggagtga ataccacgac gatttccggc agtttctaca catatattcg caagatgtgg 1200 cgtgttacgg tgaaaacctg gcctatttcc ctaaagggtt tattgagaat atgtttttcg 1260 tctcagccaa tccctgggtg agtttcacca gttttgattt aaacgtggcc aatatggaca 1320 acttcttcgc ccccgttttc accatgggca aatattatac gcaaggcgac aaggtgctga 1380 tgccgctggc gattcaggtt catcatgccg tttgtgatgg cttccatgtc ggcagaatgc 1440 ttaatgaatt acaacagtac tgcgatgagt ggcagggcgg ggcgtaaaga tctggatccg 1500 gcttactaaa agccagataa cagtatgcgt atttgcgcgc tgatttttgc ggtataagaa 1560 tatatactga tatgtatacc cgaagtatgt caaaaagagg tatgctatga agcagcgtat 1620 tacagtgaca gttgacagcg acagctatca gttgctcaag gcatatatga tgtcaatatc 1680 tccggtctgg taagcacaac catgcagaat gaagcccgtc gtctgcgtgc cgaacgctgg 1740 aaagcggaaa atcaggaagg gatggctgag gtcgcccggt ttattgaaat gaacggctct 1800 tttgctgacg agaacagggg ctggtgaaat gcagtttaag gtttacacct ataaaagaga 1860 gagccgttat cgtctgtttg tggatgtaca gagtgatatt attgacacgc ccgggcgacg 1920 gatggtgatc cccctggcca gtgcacgtct gctgtcagat aaagtctccc gtgaacttta 1980 cccggtggtg catatcgggg atgaaagctg gcgcatgatg accaccgata tggccagtgt 2040 gccggtctcc gttatcgggg aagaagtggc tgatctcagc caccgcgaaa atgacatcaa 2100 aaacgccatt aacctgatgt tctggggaat ataaatgtca ggctccctta tacacagcca 2160 gtctgcaggt cgaccatagt gactggatat gttgtgtttt acagtattat gtagtctgtt 2220 ttttatgcaa aatctaattt aatatattga tatttatatc attttacgtt tctcgttcag 2280 ctttcttgta caaagtggtt ggtaagccta tccctaaccc tctcctcggt ctcgattcta 2340 cgtagtaatg agctagcagt ctcgaggtta acgaattccg ccccccccct aacgttactg 2400 gccgaagccg cttggaataa ggccggtgtg cgcttgtcta tatgttattt tccaccatat 2460 tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc 2520 ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag 2580 cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc 2640 ggaacccccc acctggcgac aggtgcccct gcggccaaaa gccacgtgta taagatacac 2700 ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca 2760 aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt 2820 gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa 2880 aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgataat 2940 accatggcca tgattaagat cgctacgcgg aagtacctgg ggaaacagaa cgtctacgac 3000 ataggtgtgg agcgcgatca caactttgct ctgaaaaatg gatttatcgc cagcaactgc 3060 gagcccgcgt ggttcctggc caccgtcggc gtctcgcccg accaccaggg caagggtctg 3120 ggcagcgccg tcgtgctccc cggagtggag gcggccgagc gcgccggggt gcccgccttc 3180 ctggagacct ccgcgccccg caacctcccc ttctacgagc ggctcggctt caccgtcacc 3240 gccgacgtcg aggtgcccga aggaccgcgc acctggtgca tgacccgcaa gcccggtgcc 3300 tgagaattca ccggtggcgc gttaagtcga caatcaacct ctggattaca aaatttgtga 3360 aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt 3420 aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa 3480 atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt 3540 gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct 3600 cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg 3660 ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc 3720 ggggaaatca tcgtcctttc cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg 3780 gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct 3840 gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga gtcggatctc 3900 cctttgggcc gcctccccgc gtcgacttta agaccaatga cttacaaggc agctgtagat 3960 cttagccact ttttaaaaga aaagggggga ctggaagggc taattcactc ccaacgaaga 4020 caagatctgc tttttgcttg tactgggtct ctctggttag accagatctg agcctgggag 4080 ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc ttgagtgctt 4140 caagtagtgt gtgcccgtct gttgtgtgac tctggtaact agagatccct cagacccttt 4200 tagtcagtgt ggaaaatctc tagcagtacg tatagtagtt catgtcatct tattattcag 4260 tatttataac ttgcaaagaa atgaatatca gagagtgaga ggaacttgtt tattgcagct 4320 tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc atttttttca 4380 ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggctctag 4440 ctatcccgcc cctaactccg cccatcccgc ccctaactcc gcccagttcc gcccattctc 4500 cgccccatgg ctgactaatt ttttttattt atgcagaggc cgaggccgcc tcggcctctg 4560 agctattcca gaagtagtga ggaggctttt ttggaggcct agggacgtac ccaattcgcc 4620 ctatagtgag tcgtattacg cgcgctcact ggccgtcgtt ttacaacgtc gtgactggga 4680 aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg ccagctggcg 4740 taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga 4800 atgggacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt 4860 gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct 4920 cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg 4980 atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag 5040 tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa 5100 tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga 5160 tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa 5220 atttaacgcg aattttaaca aaatattaac gcttacaatt taggtggcac ttttcgggga 5280 aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc 5340 atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt 5400 caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct 5460 cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt 5520 tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt 5580 tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac 5640 gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac 5700 tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct 5760 gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg 5820 aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg 5880 gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca 5940 atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa 6000 caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt 6060 ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc 6120 attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg 6180 agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt 6240 aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt 6300 catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc 6360 ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct 6420 tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta 6480 ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc 6540 ttcagcagag cgcagatacc aaatactgtt cttctagtgt agccgtagtt aggccaccac 6600 ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct 6660 gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat 6720 aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg 6780 acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa 6840 gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg 6900 gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga 6960 cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc 7020 aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat gttctttcct 7080 gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc tgataccgct 7140 cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga agagcgccca 7200 atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg 7260 tttcccgact ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta gctcactcat 7320 taggcacccc aggctttaca ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc 7380 ggataacaat ttcacacagg aaacagctat gaccatgatt acgccaagcg cgcaattaac 7440 cctcactaaa gggaacaaaa gctggagctg caagcttaat gtagtcttat gcaatactct 7500 tgtagtcttg caacatggta acgatgagtt agcaacatgc cttacaagga gagaaaaagc 7560 accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg tgccttatta ggaaggcaac 7620 agacgggtct gacatggatt ggacgaacca ctgaattgcc gcattgcaga gatattgtat 7680 ttaagtgcct agctcgatac ataaacgggt ctctctggtt agaccagatc tgagcctggg 7740 agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc 7800 ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct 7860 tttagtcagt gtggaaaatc tctagcagtg gcgcccgaac agggacttga aagcgaaagg 7920 gaaaccagag gagctctctc gacgcaggac tcggcttgct gaagcgcgca cggcaagagg 7980 cgaggggcgg cgactggtga gtacgccaaa aattttgact agcggaggct agaaggagag 8040 agatgggtgc gagagcgtca gtattaagcg ggggagaatt agatcgcgat gggaaaaaat 8100 tcggttaagg ccagggggaa agaaaaaata taaattaaaa catatagtat gggcaagcag 8160 ggagctagaa cgattcgcag ttaatcctgg cctgttagaa acatcagaag gctgtagaca 8220 aatactggga cagctacaac catcccttca gacaggatca gaagaactta gatcattata 8280 taatacagta gcaaccctct attgtgtgca tcaaaggata gagataaaag acaccaagga 8340 agctttagac aagatagagg aagagcaaaa caaaagtaag accaccgcac agcaagcggc 8400 cgctgatctt cagacctgga ggaggagata tgagggacaa ttggagaagt gaattatata 8460 aatataaagt agtaaaaatt gaaccattag gagtagcacc caccaaggca aagagaagag 8520 tggtgcagag agaaaaaaga gcagtgggaa taggagcttt gttccttggg ttcttgggag 8580 cagcaggaag cactatgggc gcagcgtcaa tgacgctgac ggtacaggcc agacaattat 8640 tgtctggtat agtgcagcag cagaacaatt tgctgagggc tattgaggcg caacagcatc 8700 tgttgcaact cacagtctgg ggcatcaagc agctccaggc aagaatcctg gctgtggaaa 8760 gatacctaaa ggatcaacag ctcctgggga tttggggttg ctctggaaaa ctcatttgca 8820 ccactgctgt gccttggaat gctagttgga gtaataaatc tctggaacag atttggaatc 8880 acacgacctg gatggagtgg gacagagaaa ttaacaatta cacaagctta atacactcct 8940 taattgaaga atcgcaaaac cagcaagaaa agaatgaaca agaattattg gaattagata 9000 aatgggcaag tttgtggaat tggtttaaca taacaaattg gctgtggtat ataaaattat 9060 tcataatgat agtaggaggc ttggtaggtt taagaatagt ttttgctgta ctttctatag 9120 tgaatagagt taggcaggga tattcaccat tatcgtttca gacccacctc ccaaccccga 9180 ggggaccctt gcgccttttc caaggcagcc ctgggtttgc gcagggacgc ggctgctctg 9240 ggcgtggttc cgggaaacgc agcggcgccg accctgggtc tcgcacattc ttcacgtccg 9300 ttcgcagcgt cacccggatc ttcgccgcta cccttgtggg ccccccggcg acgcttcctg 9360 ctccgcccct aagtcgggaa ggttccttgc ggttcgcggc gtgccggacg tgacaaacgg 9420 aagccgcacg tctcactagt accctcgcag acggacagcg ccagggagca atggcagcgc 9480 gccgaccgcg atgggctgtg gccaatagcg gctgctcagc agggcgcgcc gagagcagcg 9540 gccgggaagg ggcggtgcgg gaggcggggt gtggggcggt agtgtgggcc ctgttcctgc 9600 ccgcgcggtg ttccgcattc tgcaagcctc cggagcgcac gtcggcagtc ggctccctcg 9660 ttgaccgaat caccgacctc tctccccagg gggtacccag ctgtctagag aattctagat 9720 cttgagacaa atggcagtat tcatccacaa ttttaaaaga aaagggggga ttggggggta 9780 cagtgcaggg gaaagaatag tagacataat agcaacagac atacaaacta aagaattaca 9840 aaaacaaatt acaaaaattc aaaattttcg ggtttattac agggacagca gagatccact 9900 ttggcgccgg ctcgaggggg 9920 <210> 111 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 111 Met Ala Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn 1 5 10 15 Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn 20 25 30 Gly Phe Ile Ala Ser Asn Cys Glu Pro Ala Trp Phe Leu Ala Thr Val 35 40 45 Gly Val Ser Pro Asp His Gln Gly Lys Gly Leu Gly Ser Ala Val Val 50 55 60 Leu Pro Gly Val Glu Ala Ala Glu Arg Ala Gly Val Pro Ala Phe Leu 65 70 75 80 Glu Thr Ser Ala Pro Arg Asn Leu Pro Phe Tyr Glu Arg Leu Gly Phe 85 90 95 Thr Val Thr Ala Asp Val Glu Val Pro Glu Gly Pro Arg Thr Trp Cys 100 105 110 Met Thr Arg Lys Pro Gly Ala 115 <210> 112 <211> 9317 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 112 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgagcga gctgattaag 660 gagaacatgc acatgaagct gtacatggag ggcaccgtgg acaaccatca cttcaagtgc 720 acatccgagg gcgaaggcaa gccctacgag ggcacccaga ccatgagaat caaggtggtc 780 gagggcggcc ctctcccctt cgccttcgac atcctggcta ctagcttcct ctacggcagc 840 aagaccttca tcaaccacac ccagggcatc cccgacttct tcaagcagtc cttccctgag 900 ggcttcacat gggagagagt caccacatac gaagacgggg gcgtgctgac cgctacccag 960 gacaccagcc tccaggacgg ctgcctcatc tacaacgtca agatcagagg ggtgaacttc 1020 acatccaacg gccctgtgat gcagaagaaa acactcggct gggaggcctt caccgagacg 1080 ctgtaccccg ctgacggcgg cctggaaggc agaaacgaca tggccctgaa gctcgtgggc 1140 gggagccatc tgatcgcaaa catcaagacc acatatagat ccaagaaacc cgctaagaac 1200 ctcaagatgc ctggcgtcta ctatgtggac tacagactgg aaagaatcaa ggaggccaac 1260 aacgagacct acgtcgagca gcacgaggtg gcagtggcca gatactgcga cctccctagc 1320 aaactggggc acaagcttaa ttaattaatt aagaattcga cccagctttc ttgtacaaag 1380 tggttggtaa gcctatccct aaccctctcc tcggtctcga ttctacgtag taatgagcta 1440 gcagtctcga ggttaacgaa ttccgccccc cccctaacgt tactggccga agccgcttgg 1500 aataaggccg gtgtgcgctt gtctatatgt tattttccac catattgccg tcttttggca 1560 atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg ggtctttccc 1620 ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt cctctggaag 1680 cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac cccccacctg 1740 gcgacaggtg cccctgcggc caaaagccac gtgtataaga tacacctgca aaggcggcac 1800 aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg ctctcctcaa 1860 gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg ggatctgatc 1920 tggggcctcg gtgcacatgc tttacatgtg tttagtcgag gttaaaaaaa cgtctaggcc 1980 ccccgaacca cggggacgtg gttttccttt gaaaaacacg ataataccat ggccatgacc 2040 gagtacaagc ccacggtgcg cctcgccacc cgcgacgacg tccccagggc cgtacgcacc 2100 ctcgccgccg cgttcgccga ctaccccgcc acgcgccaca ccgtcgatcc ggaccgccac 2160 atcgagcggg tcaccgagct gcaagaactc ttcctcacgc gcgtcgggct cgacatcggc 2220 aaggtgtggg tcgcggacga cggcgccgcg gtggcggtct ggaccacgcc ggagagcgtc 2280 gaagcggggg cggtgttcgc cgagatcggc ccgcgcatgg ccgagttgag cggttcccgg 2340 ctggccgcgc agcaacagat ggaaggcctc ctggcgccgc accggcccaa gtgcctttca 2400 tacgagaccg agatcctgac tgtcgagtac ggattgcttc ctatcggcaa aatcgtggag 2460 aagaggattg aatgtaccgt ctattcagtc gataataatg ggaacatcta cacacagccc 2520 gtggctcaat ggcacgacag aggagagcag gaagtttttg aatactgtct cgaggacgga 2580 tccctcatcc gcgctactaa agatcataag tttatgaccg tggacggcca gatgctgcca 2640 attgacgaaa tttttgaacg agagctggat ctgatgagag tcgacaacct tccaaactga 2700 gaattcaccg gtggcgcgtt aagtcgacaa tcaacctctg gattacaaaa tttgtgaaag 2760 attgactggt attcttaact atgttgctcc ttttacgcta tgtggatacg ctgctttaat 2820 gcctttgtat catgctattg cttcccgtat ggctttcatt ttctcctcct tgtataaatc 2880 ctggttgctg tctctttatg aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg 2940 cactgtgttt gctgacgcaa cccccactgg ttggggcatt gccaccacct gtcagctcct 3000 ttccgggact ttcgctttcc ccctccctat tgccacggcg gaactcatcg ccgcctgcct 3060 tgcccgctgc tggacagggg ctcggctgtt gggcactgac aattccgtgg tgttgtcggg 3120 gaaatcatcg tcctttcctt ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac 3180 gtccttctgc tacgtccctt cggccctcaa tccagcggac cttccttccc gcggcctgct 3240 gccggctctg cggcctcttc cgcgtcttcg ccttcgccct cagacgagtc ggatctccct 3300 ttgggccgcc tccccgcgtc gactttaaga ccaatgactt acaaggcagc tgtagatctt 3360 agccactttt taaaagaaaa ggggggactg gaagggctaa ttcactccca acgaagacaa 3420 gatctgcttt ttgcttgtac tgggtctctc tggttagacc agatctgagc ctgggagctc 3480 tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgcttcaa 3540 gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag 3600 tcagtgtgga aaatctctag cagtacgtat agtagttcat gtcatcttat tattcagtat 3660 ttataacttg caaagaaatg aatatcagag agtgagagga acttgtttat tgcagcttat 3720 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 3780 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gctctagcta 3840 tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc cattctccgc 3900 cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg gcctctgagc 3960 tattccagaa gtagtgagga ggcttttttg gaggcctagg gacgtaccca attcgcccta 4020 tagtgagtcg tattacgcgc gctcactggc cgtcgtttta caacgtcgtg actgggaaaa 4080 ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca gctggcgtaa 4140 tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga atggcgaatg 4200 ggacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac 4260 cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt cctttctcgc 4320 cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag ggttccgatt 4380 tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt cacgtagtgg 4440 gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt tctttaatag 4500 tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt cttttgattt 4560 ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt aacaaaaatt 4620 taacgcgaat tttaacaaaa tattaacgct tacaatttag gtggcacttt tcggggaaat 4680 gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg 4740 agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa 4800 catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac 4860 ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac 4920 atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt 4980 ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc 5040 gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca 5100 ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc 5160 ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag 5220 gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa 5280 ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg 5340 gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa 5400 ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg 5460 gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt 5520 gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt 5580 caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag 5640 cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat 5700 ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct 5760 taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct 5820 tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca 5880 gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc 5940 agcagagcgc agataccaaa tactgttctt ctagtgtagc cgtagttagg ccaccacttc 6000 aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct 6060 gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag 6120 gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc 6180 tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg 6240 agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag 6300 cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt 6360 gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac 6420 gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg 6480 ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc 6540 cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcccaata 6600 cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca cgacaggttt 6660 cccgactgga aagcgggcag tgagcgcaac gcaattaatg tgagttagct cactcattag 6720 gcaccccagg ctttacactt tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga 6780 taacaatttc acacaggaaa cagctatgac catgattacg ccaagcgcgc aattaaccct 6840 cactaaaggg aacaaaagct ggagctgcaa gcttaatgta gtcttatgca atactcttgt 6900 agtcttgcaa catggtaacg atgagttagc aacatgcctt acaaggagag aaaaagcacc 6960 gtgcatgccg attggtggaa gtaaggtggt acgatcgtgc cttattagga aggcaacaga 7020 cgggtctgac atggattgga cgaaccactg aattgccgca ttgcagagat attgtattta 7080 agtgcctagc tcgatacata aacgggtctc tctggttaga ccagatctga gcctgggagc 7140 tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc 7200 aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt 7260 agtcagtgtg gaaaatctct agcagtggcg cccgaacagg gacttgaaag cgaaagggaa 7320 accagaggag ctctctcgac gcaggactcg gcttgctgaa gcgcgcacgg caagaggcga 7380 ggggcggcga ctggtgagta cgccaaaaat tttgactagc ggaggctaga aggagagaga 7440 tgggtgcgag agcgtcagta ttaagcgggg gagaattaga tcgcgatggg aaaaaattcg 7500 gttaaggcca gggggaaaga aaaaatataa attaaaacat atagtatggg caagcaggga 7560 gctagaacga ttcgcagtta atcctggcct gttagaaaca tcagaaggct gtagacaaat 7620 actgggacag ctacaaccat cccttcagac aggatcagaa gaacttagat cattatataa 7680 tacagtagca accctctatt gtgtgcatca aaggatagag ataaaagaca ccaaggaagc 7740 tttagacaag atagaggaag agcaaaacaa aagtaagacc accgcacagc aagcggccgc 7800 tgatcttcag acctggagga ggagatatga gggacaattg gagaagtgaa ttatataaat 7860 ataaagtagt aaaaattgaa ccattaggag tagcacccac caaggcaaag agaagagtgg 7920 tgcagagaga aaaaagagca gtgggaatag gagctttgtt ccttgggttc ttgggagcag 7980 caggaagcac tatgggcgca gcgtcaatga cgctgacggt acaggccaga caattattgt 8040 ctggtatagt gcagcagcag aacaatttgc tgagggctat tgaggcgcaa cagcatctgt 8100 tgcaactcac agtctggggc atcaagcagc tccaggcaag aatcctggct gtggaaagat 8160 acctaaagga tcaacagctc ctggggattt ggggttgctc tggaaaactc atttgcacca 8220 ctgctgtgcc ttggaatgct agttggagta ataaatctct ggaacagatt tggaatcaca 8280 cgacctggat ggagtgggac agagaaatta acaattacac aagcttaata cactccttaa 8340 ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga attattggaa ttagataaat 8400 gggcaagttt gtggaattgg tttaacataa caaattggct gtggtatata aaattattca 8460 taatgatagt aggaggcttg gtaggtttaa gaatagtttt tgctgtactt tctatagtga 8520 atagagttag gcagggatat tcaccattat cgtttcagac ccacctccca accccgaggg 8580 gacccttgcg ccttttccaa ggcagccctg ggtttgcgca gggacgcggc tgctctgggc 8640 gtggttccgg gaaacgcagc ggcgccgacc ctgggtctcg cacattcttc acgtccgttc 8700 gcagcgtcac ccggatcttc gccgctaccc ttgtgggccc cccggcgacg cttcctgctc 8760 cgcccctaag tcgggaaggt tccttgcggt tcgcggcgtg ccggacgtga caaacggaag 8820 ccgcacgtct cactagtacc ctcgcagacg gacagcgcca gggagcaatg gcagcgcgcc 8880 gaccgcgatg ggctgtggcc aatagcggct gctcagcagg gcgcgccgag agcagcggcc 8940 gggaaggggc ggtgcgggag gcggggtgtg gggcggtagt gtgggccctg ttcctgcccg 9000 cgcggtgttc cgcattctgc aagcctccgg agcgcacgtc ggcagtcggc tccctcgttg 9060 accgaatcac cgacctctct ccccaggggg tacccagctg tctagagaat tctagatctt 9120 gagacaaatg gcagtattca tccacaattt taaaagaaaa ggggggattg gggggtacag 9180 tgcaggggaa agaatagtag acataatagc aacagacata caaactaaag aattacaaaa 9240 acaaattaca aaaattcaaa attttcgggt ttattacagg gacagcagag atccactttg 9300 gcgccggctc gaggggg 9317 <210> 113 <211> 9014 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 113 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggtgag caagggcgag 660 gaggataaca tggccatcat caaggagttc atgcgcttca aggtgcacat ggagggctcc 720 gtgaacggcc acgagttcga gatcgagggc gagggcgagg gccgccccta cgagggcacc 780 cagaccgcca agctgaaggt gaccaagggt ggccccctgc ccttcgcctg ggacatcctg 840 tcccctcagt tcatgtacgg ctccaaggcc tacgtgaagc accccgccga catccccgac 900 tacttgaagc tgtccttccc cgagggcttc aagtgggagc gcgtgatgaa cttcgaggac 960 ggcggcgtgg tgaccgtgac ccaggactcc tccctgcagg acggcgagtt catctacaag 1020 gtgaagctgc gcggcaccaa cttcccctcc gacggccccg taatgcagaa gaagaccatg 1080 ggctgggagg cctcctccga gcggatgtac cccgaggacg gcgccctgaa gggcgagatc 1140 aagcagaggc tgaagctgaa ggacggcggc cactacgacg ctgaggtcaa gaccacctac 1200 aaggccaaga agcccgtgca gctgcccggc gcctacaacg tcaacattaa gttggacatc 1260 acctcccaca acgaggacta caccatcgtg gaacagtacg aacgcgccga gggccgccac 1320 tccaccggcg gcatggacga gctgtacaag tgattaatta agaattcgac ccagctttct 1380 tgtacaaagt ggttggtaag cctatcccta accctctcct cggtctcgat tctacgtagt 1440 aatgagctag cagtctcgag gttaacgaat tccgcccccc ccctaacgtt actggccgaa 1500 gccgcttgga ataaggccgg tgtgcgcttg tctatatgtt attttccacc atattgccgt 1560 cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg 1620 gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc 1680 ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc 1740 ccccacctgg cgacaggtgc ccctgcggcc aaaagccacg tgtataagat acacctgcaa 1800 aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc 1860 tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg 1920 gatctgatct ggggcctcgg tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaaac 1980 gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga taataccatg 2040 gccatgatta agatcgctac gcggaagtac ctggggaaac agaacgtcta cgacataggt 2100 gtggagcgcg atcacaactt tgctctgaaa aatggattta tcgccagcaa ctgcgagccc 2160 gcgtggttcc tggccaccgt cggcgtctcg cccgaccacc agggcaaggg tctgggcagc 2220 gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg gggtgcccgc cttcctggag 2280 acctccgcgc cccgcaacct ccccttctac gagcggctcg gcttcaccgt caccgccgac 2340 gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc gcaagcccgg tgcctgagaa 2400 ttcaccggtg gcgcgttaag tcgacaatca acctctggat tacaaaattt gtgaaagatt 2460 gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg ctttaatgcc 2520 tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt ataaatcctg 2580 gttgctgtct ctttatgagg agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac 2640 tgtgtttgct gacgcaaccc ccactggttg gggcattgcc accacctgtc agctcctttc 2700 cgggactttc gctttccccc tccctattgc cacggcggaa ctcatcgccg cctgccttgc 2760 ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt tgtcggggaa 2820 atcatcgtcc tttccttggc tgctcgcctg tgttgccacc tggattctgc gcgggacgtc 2880 cttctgctac gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc 2940 ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga tctccctttg 3000 ggccgcctcc ccgcgtcgac tttaagacca atgacttaca aggcagctgt agatcttagc 3060 cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaacg aagacaagat 3120 ctgctttttg cttgtactgg gtctctctgg ttagaccaga tctgagcctg ggagctctct 3180 ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt gcttcaagta 3240 gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc cttttagtca 3300 gtgtggaaaa tctctagcag tacgtatagt agttcatgtc atcttattat tcagtattta 3360 taacttgcaa agaaatgaat atcagagagt gagaggaact tgtttattgc agcttataat 3420 ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat 3480 tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggct ctagctatcc 3540 cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc 3600 atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc tctgagctat 3660 tccagaagta gtgaggaggc ttttttggag gcctagggac gtacccaatt cgccctatag 3720 tgagtcgtat tacgcgcgct cactggccgt cgttttacaa cgtcgtgact gggaaaaccc 3780 tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct ggcgtaatag 3840 cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg gcgaatggga 3900 cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc 3960 tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac 4020 gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag 4080 tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc 4140 atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg 4200 actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata 4260 agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa 4320 cgcgaatttt aacaaaatat taacgcttac aatttaggtg gcacttttcg gggaaatgtg 4380 cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga 4440 caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat 4500 ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca 4560 gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc 4620 gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca 4680 atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg 4740 caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca 4800 gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata 4860 accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag 4920 ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg 4980 gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca 5040 acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaatta 5100 atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct 5160 ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca 5220 gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag 5280 gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat 5340 tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa acttcatttt 5400 taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa 5460 cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga 5520 gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg 5580 gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc 5640 agagcgcaga taccaaatac tgttcttcta gtgtagccgt agttaggcca ccacttcaag 5700 aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc 5760 agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg 5820 cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac 5880 accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga 5940 aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt 6000 ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag 6060 cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg 6120 gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta 6180 tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc 6240 agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cccaatacgc 6300 aaaccgcctc tccccgcgcg ttggccgatt cattaatgca gctggcacga caggtttccc 6360 gactggaaag cgggcagtga gcgcaacgca attaatgtga gttagctcac tcattaggca 6420 ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 6480 caatttcaca caggaaacag ctatgaccat gattacgcca agcgcgcaat taaccctcac 6540 taaagggaac aaaagctgga gctgcaagct taatgtagtc ttatgcaata ctcttgtagt 6600 cttgcaacat ggtaacgatg agttagcaac atgccttaca aggagagaaa aagcaccgtg 6660 catgccgatt ggtggaagta aggtggtacg atcgtgcctt attaggaagg caacagacgg 6720 gtctgacatg gattggacga accactgaat tgccgcattg cagagatatt gtatttaagt 6780 gcctagctcg atacataaac gggtctctct ggttagacca gatctgagcc tgggagctct 6840 ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag 6900 tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt 6960 cagtgtggaa aatctctagc agtggcgccc gaacagggac ttgaaagcga aagggaaacc 7020 agaggagctc tctcgacgca ggactcggct tgctgaagcg cgcacggcaa gaggcgaggg 7080 gcggcgactg gtgagtacgc caaaaatttt gactagcgga ggctagaagg agagagatgg 7140 gtgcgagagc gtcagtatta agcgggggag aattagatcg cgatgggaaa aaattcggtt 7200 aaggccaggg ggaaagaaaa aatataaatt aaaacatata gtatgggcaa gcagggagct 7260 agaacgattc gcagttaatc ctggcctgtt agaaacatca gaaggctgta gacaaatact 7320 gggacagcta caaccatccc ttcagacagg atcagaagaa cttagatcat tatataatac 7380 agtagcaacc ctctattgtg tgcatcaaag gatagagata aaagacacca aggaagcttt 7440 agacaagata gaggaagagc aaaacaaaag taagaccacc gcacagcaag cggccgctga 7500 tcttcagacc tggaggagga gatatgaggg acaattggag aagtgaatta tataaatata 7560 aagtagtaaa aattgaacca ttaggagtag cacccaccaa ggcaaagaga agagtggtgc 7620 agagagaaaa aagagcagtg ggaataggag ctttgttcct tgggttcttg ggagcagcag 7680 gaagcactat gggcgcagcg tcaatgacgc tgacggtaca ggccagacaa ttattgtctg 7740 gtatagtgca gcagcagaac aatttgctga gggctattga ggcgcaacag catctgttgc 7800 aactcacagt ctggggcatc aagcagctcc aggcaagaat cctggctgtg gaaagatacc 7860 taaaggatca acagctcctg gggatttggg gttgctctgg aaaactcatt tgcaccactg 7920 ctgtgccttg gaatgctagt tggagtaata aatctctgga acagatttgg aatcacacga 7980 cctggatgga gtgggacaga gaaattaaca attacacaag cttaatacac tccttaattg 8040 aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt attggaatta gataaatggg 8100 caagtttgtg gaattggttt aacataacaa attggctgtg gtatataaaa ttattcataa 8160 tgatagtagg aggcttggta ggtttaagaa tagtttttgc tgtactttct atagtgaata 8220 gagttaggca gggatattca ccattatcgt ttcagaccca cctcccaacc ccgaggggac 8280 ccttgcgcct tttccaaggc agccctgggt ttgcgcaggg acgcggctgc tctgggcgtg 8340 gttccgggaa acgcagcggc gccgaccctg ggtctcgcac attcttcacg tccgttcgca 8400 gcgtcacccg gatcttcgcc gctacccttg tgggcccccc ggcgacgctt cctgctccgc 8460 ccctaagtcg ggaaggttcc ttgcggttcg cggcgtgccg gacgtgacaa acggaagccg 8520 cacgtctcac tagtaccctc gcagacggac agcgccaggg agcaatggca gcgcgccgac 8580 cgcgatgggc tgtggccaat agcggctgct cagcagggcg cgccgagagc agcggccggg 8640 aaggggcggt gcgggaggcg gggtgtgggg cggtagtgtg ggccctgttc ctgcccgcgc 8700 ggtgttccgc attctgcaag cctccggagc gcacgtcggc agtcggctcc ctcgttgacc 8760 gaatcaccga cctctctccc cagggggtac ccagctgtct agagaattct agatcttgag 8820 acaaatggca gtattcatcc acaattttaa aagaaaaggg gggattgggg ggtacagtgc 8880 aggggaaaga atagtagaca taatagcaac agacatacaa actaaagaat tacaaaaaca 8940 aattacaaaa attcaaaatt ttcgggttta ttacagggac agcagagatc cactttggcg 9000 ccggctcgag gggg 9014 <210> 114 <211> 10451 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 114 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagctgaacg agaaacgtaa aatgatataa atatcaatat attaaattag 660 attttgcata aaaaacagac tacataatac tgtaaaacac aacatatcca gtcactatgg 720 cggccgcatt aggcacccca ggctttacac tttatgcttc cggctcgtat aatgtgtgga 780 ttttgagtta ggatccgtcg agattttcag gagctaagga agctaaaatg gagaaaaaaa 840 tcactggata taccaccgtt gatatatccc aatggcatcg taaagaacat tttgaggcat 900 ttcagtcagt tgctcaatgt acctataacc agaccgttca gctggatatt acggcctttt 960 taaagaccgt aaagaaaaat aagcacaagt tttatccggc ctttattcac attcttgccc 1020 gcctgatgaa tgctcatccg gaattccgta tggcaatgaa agacggtgag ctggtgatat 1080 gggatagtgt tcacccttgt tacaccgttt tccatgagca aactgaaacg ttttcatcgc 1140 tctggagtga ataccacgac gatttccggc agtttctaca catatattcg caagatgtgg 1200 cgtgttacgg tgaaaacctg gcctatttcc ctaaagggtt tattgagaat atgtttttcg 1260 tctcagccaa tccctgggtg agtttcacca gttttgattt aaacgtggcc aatatggaca 1320 acttcttcgc ccccgttttc accatgggca aatattatac gcaaggcgac aaggtgctga 1380 tgccgctggc gattcaggtt catcatgccg tttgtgatgg cttccatgtc ggcagaatgc 1440 ttaatgaatt acaacagtac tgcgatgagt ggcagggcgg ggcgtaaaga tctggatccg 1500 gcttactaaa agccagataa cagtatgcgt atttgcgcgc tgatttttgc ggtataagaa 1560 tatatactga tatgtatacc cgaagtatgt caaaaagagg tatgctatga agcagcgtat 1620 tacagtgaca gttgacagcg acagctatca gttgctcaag gcatatatga tgtcaatatc 1680 tccggtctgg taagcacaac catgcagaat gaagcccgtc gtctgcgtgc cgaacgctgg 1740 aaagcggaaa atcaggaagg gatggctgag gtcgcccggt ttattgaaat gaacggctct 1800 tttgctgacg agaacagggg ctggtgaaat gcagtttaag gtttacacct ataaaagaga 1860 gagccgttat cgtctgtttg tggatgtaca gagtgatatt attgacacgc ccgggcgacg 1920 gatggtgatc cccctggcca gtgcacgtct gctgtcagat aaagtctccc gtgaacttta 1980 cccggtggtg catatcgggg atgaaagctg gcgcatgatg accaccgata tggccagtgt 2040 gccggtctcc gttatcgggg aagaagtggc tgatctcagc caccgcgaaa atgacatcaa 2100 aaacgccatt aacctgatgt tctggggaat ataaatgtca ggctccctta tacacagcca 2160 gtctgcaggt cgaccatagt gactggatat gttgtgtttt acagtattat gtagtctgtt 2220 ttttatgcaa aatctaattt aatatattga tatttatatc attttacgtt tctcgttcag 2280 ctttcttgta caaagtggtt ggtaagccta tccctaaccc tctcctcggt ctcgattcta 2340 cgtagtaatg agctagcagt ctcgaggtta acgaattccg ccccccccct aacgttactg 2400 gccgaagccg cttggaataa ggccggtgtg cgcttgtcta tatgttattt tccaccatat 2460 tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc 2520 ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag 2580 cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc 2640 ggaacccccc acctggcgac aggtgcccct gcggccaaaa gccacgtgta taagatacac 2700 ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca 2760 aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt 2820 gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa 2880 aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgataat 2940 accatgggat cggccattga acaagatgga ttgcacgcag gttctccggc cgcttgggtg 3000 gagaggctat tcggctatga ctgggcacaa cagacaatcg gctgctctga tgccgccgtg 3060 ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca agaccgacct gtccggtgcc 3120 ctgaatgaac tgcaggacga ggcagcgcgg ctatcgtggc tggccacgac gggcgttcct 3180 tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg actggctgct attgggcgaa 3240 gtgccggggc aggatctcct gtcatctcac cttgctcctg ccgagaaagt atccatcatg 3300 gctgatgcaa tgcggcggct gcatacgctt gatccggcta cctgcccatt cgaccaccaa 3360 gcgaaacatc gcatcgagcg agcacgtact cggatggaag ccggtcttgt cgatcaggat 3420 gatctggacg aagagcatca ggggctcgcg ccagccgaac tgttcgccag gctcaaggcg 3480 cgcatgcccg acggcgatga tctcgtcgtg acccatggcg atgcctgcct ttcatacgag 3540 accgagatcc tgactgtcga gtacggattg cttcctatcg gcaaaatcgt ggagaagagg 3600 attgaatgta ccgtctattc agtcgataat aatgggaaca tctacacaca gcccgtggct 3660 caatggcacg acagaggaga gcaggaagtt tttgaatact gtctcgagga cggatccctc 3720 atccgcgcta ctaaagatca taagtttatg accgtggacg gccagatgct gccaattgac 3780 gaaatttttg aacgagagct ggatctgatg agagtcgaca accttccaaa ctgagaattc 3840 accggtggcg cgttaagtcg acaatcaacc tctggattac aaaatttgtg aaagattgac 3900 tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt taatgccttt 3960 gtatcatgct attgcttccc gtatggcttt cattttctcc tccttgtata aatcctggtt 4020 gctgtctctt tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt 4080 gtttgctgac gcaaccccca ctggttgggg cattgccacc acctgtcagc tcctttccgg 4140 gactttcgct ttccccctcc ctattgccac ggcggaactc atcgccgcct gccttgcccg 4200 ctgctggaca ggggctcggc tgttgggcac tgacaattcc gtggtgttgt cggggaaatc 4260 atcgtccttt ccttggctgc tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt 4320 ctgctacgtc ccttcggccc tcaatccagc ggaccttcct tcccgcggcc tgctgccggc 4380 tctgcggcct cttccgcgtc ttcgccttcg ccctcagacg agtcggatct ccctttgggc 4440 cgcctccccg cgtcgacttt aagaccaatg acttacaagg cagctgtaga tcttagccac 4500 tttttaaaag aaaagggggg actggaaggg ctaattcact cccaacgaag acaagatctg 4560 ctttttgctt gtactgggtc tctctggtta gaccagatct gagcctggga gctctctggc 4620 taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg 4680 tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg 4740 tggaaaatct ctagcagtac gtatagtagt tcatgtcatc ttattattca gtatttataa 4800 cttgcaaaga aatgaatatc agagagtgag aggaacttgt ttattgcagc ttataatggt 4860 tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 4920 agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggctcta gctatcccgc 4980 ccctaactcc gcccatcccg cccctaactc cgcccagttc cgcccattct ccgccccatg 5040 gctgactaat tttttttatt tatgcagagg ccgaggccgc ctcggcctct gagctattcc 5100 agaagtagtg aggaggcttt tttggaggcc tagggacgta cccaattcgc cctatagtga 5160 gtcgtattac gcgcgctcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg 5220 cgttacccaa cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga 5280 agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatgggacgc 5340 gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac 5400 acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt 5460 cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc 5520 tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc 5580 gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact 5640 cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg 5700 gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc 5760 gaattttaac aaaatattaa cgcttacaat ttaggtggca cttttcgggg aaatgtgcgc 5820 ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa 5880 taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc 5940 cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa 6000 acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa 6060 ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg 6120 atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga cgccgggcaa 6180 gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc 6240 acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc 6300 atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta 6360 accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag 6420 ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc aatggcaaca 6480 acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca acaattaata 6540 gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc 6600 tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca 6660 ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca 6720 actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg 6780 taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa 6840 tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt 6900 gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat 6960 cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg 7020 gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga 7080 gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac 7140 tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt 7200 ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag 7260 cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc 7320 gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag 7380 gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca 7440 gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt 7500 cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc 7560 tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc 7620 cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc 7680 cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa 7740 ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac 7800 tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc 7860 caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa 7920 tttcacacag gaaacagcta tgaccatgat tacgccaagc gcgcaattaa ccctcactaa 7980 agggaacaaa agctggagct gcaagcttaa tgtagtctta tgcaatactc ttgtagtctt 8040 gcaacatggt aacgatgagt tagcaacatg ccttacaagg agagaaaaag caccgtgcat 8100 gccgattggt ggaagtaagg tggtacgatc gtgccttatt aggaaggcaa cagacgggtc 8160 tgacatggat tggacgaacc actgaattgc cgcattgcag agatattgta tttaagtgcc 8220 tagctcgata cataaacggg tctctctggt tagaccagat ctgagcctgg gagctctctg 8280 gctaactagg gaacccactg cttaagcctc aataaagctt gccttgagtg cttcaagtag 8340 tgtgtgcccg tctgttgtgt gactctggta actagagatc cctcagaccc ttttagtcag 8400 tgtggaaaat ctctagcagt ggcgcccgaa cagggacttg aaagcgaaag ggaaaccaga 8460 ggagctctct cgacgcagga ctcggcttgc tgaagcgcgc acggcaagag gcgaggggcg 8520 gcgactggtg agtacgccaa aaattttgac tagcggaggc tagaaggaga gagatgggtg 8580 cgagagcgtc agtattaagc gggggagaat tagatcgcga tgggaaaaaa ttcggttaag 8640 gccaggggga aagaaaaaat ataaattaaa acatatagta tgggcaagca gggagctaga 8700 acgattcgca gttaatcctg gcctgttaga aacatcagaa ggctgtagac aaatactggg 8760 acagctacaa ccatcccttc agacaggatc agaagaactt agatcattat ataatacagt 8820 agcaaccctc tattgtgtgc atcaaaggat agagataaaa gacaccaagg aagctttaga 8880 caagatagag gaagagcaaa acaaaagtaa gaccaccgca cagcaagcgg ccgctgatct 8940 tcagacctgg aggaggagat atgagggaca attggagaag tgaattatat aaatataaag 9000 tagtaaaaat tgaaccatta ggagtagcac ccaccaaggc aaagagaaga gtggtgcaga 9060 gagaaaaaag agcagtggga ataggagctt tgttccttgg gttcttggga gcagcaggaa 9120 gcactatggg cgcagcgtca atgacgctga cggtacaggc cagacaatta ttgtctggta 9180 tagtgcagca gcagaacaat ttgctgaggg ctattgaggc gcaacagcat ctgttgcaac 9240 tcacagtctg gggcatcaag cagctccagg caagaatcct ggctgtggaa agatacctaa 9300 aggatcaaca gctcctgggg atttggggtt gctctggaaa actcatttgc accactgctg 9360 tgccttggaa tgctagttgg agtaataaat ctctggaaca gatttggaat cacacgacct 9420 ggatggagtg ggacagagaa attaacaatt acacaagctt aatacactcc ttaattgaag 9480 aatcgcaaaa ccagcaagaa aagaatgaac aagaattatt ggaattagat aaatgggcaa 9540 gtttgtggaa ttggtttaac ataacaaatt ggctgtggta tataaaatta ttcataatga 9600 tagtaggagg cttggtaggt ttaagaatag tttttgctgt actttctata gtgaatagag 9660 ttaggcaggg atattcacca ttatcgtttc agacccacct cccaaccccg aggggaccct 9720 tgcgcctttt ccaaggcagc cctgggtttg cgcagggacg cggctgctct gggcgtggtt 9780 ccgggaaacg cagcggcgcc gaccctgggt ctcgcacatt cttcacgtcc gttcgcagcg 9840 tcacccggat cttcgccgct acccttgtgg gccccccggc gacgcttcct gctccgcccc 9900 taagtcggga aggttccttg cggttcgcgg cgtgccggac gtgacaaacg gaagccgcac 9960 gtctcactag taccctcgca gacggacagc gccagggagc aatggcagcg cgccgaccgc 10020 gatgggctgt ggccaatagc ggctgctcag cagggcgcgc cgagagcagc ggccgggaag 10080 gggcggtgcg ggaggcgggg tgtggggcgg tagtgtgggc cctgttcctg cccgcgcggt 10140 gttccgcatt ctgcaagcct ccggagcgca cgtcggcagt cggctccctc gttgaccgaa 10200 tcaccgacct ctctccccag ggggtaccca gctgtctaga gaattctaga tcttgagaca 10260 aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg 10320 ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat 10380 tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccac tttggcgccg 10440 gctcgagggg g 10451 <210> 115 <211> 296 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 115 Met Gly Ser Ala Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala 1 5 10 15 Ala Trp Val Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile 20 25 30 Gly Cys Ser Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro 35 40 45 Val Leu Phe Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln 50 55 60 Asp Glu Ala Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys 65 70 75 80 Ala Ala Val Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu 85 90 95 Leu Gly Glu Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro 100 105 110 Ala Glu Lys Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr 115 120 125 Leu Asp Pro Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile 130 135 140 Glu Arg Ala Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp 145 150 155 160 Leu Asp Glu Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg 165 170 175 Leu Lys Ala Arg Met Pro Asp Gly Asp Asp Leu Val Val Thr His Gly 180 185 190 Asp Ala Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly 195 200 205 Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val 210 215 220 Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln 225 230 235 240 Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp 245 250 255 Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp 260 265 270 Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu 275 280 285 Met Arg Val Asp Asn Leu Pro Asn 290 295 <210> 116 <211> 9896 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 116 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagctgaacg agaaacgtaa aatgatataa atatcaatat attaaattag 660 attttgcata aaaaacagac tacataatac tgtaaaacac aacatatcca gtcactatgg 720 cggccgcatt aggcacccca ggctttacac tttatgcttc cggctcgtat aatgtgtgga 780 ttttgagtta ggatccgtcg agattttcag gagctaagga agctaaaatg gagaaaaaaa 840 tcactggata taccaccgtt gatatatccc aatggcatcg taaagaacat tttgaggcat 900 ttcagtcagt tgctcaatgt acctataacc agaccgttca gctggatatt acggcctttt 960 taaagaccgt aaagaaaaat aagcacaagt tttatccggc ctttattcac attcttgccc 1020 gcctgatgaa tgctcatccg gaattccgta tggcaatgaa agacggtgag ctggtgatat 1080 gggatagtgt tcacccttgt tacaccgttt tccatgagca aactgaaacg ttttcatcgc 1140 tctggagtga ataccacgac gatttccggc agtttctaca catatattcg caagatgtgg 1200 cgtgttacgg tgaaaacctg gcctatttcc ctaaagggtt tattgagaat atgtttttcg 1260 tctcagccaa tccctgggtg agtttcacca gttttgattt aaacgtggcc aatatggaca 1320 acttcttcgc ccccgttttc accatgggca aatattatac gcaaggcgac aaggtgctga 1380 tgccgctggc gattcaggtt catcatgccg tttgtgatgg cttccatgtc ggcagaatgc 1440 ttaatgaatt acaacagtac tgcgatgagt ggcagggcgg ggcgtaaaga tctggatccg 1500 gcttactaaa agccagataa cagtatgcgt atttgcgcgc tgatttttgc ggtataagaa 1560 tatatactga tatgtatacc cgaagtatgt caaaaagagg tatgctatga agcagcgtat 1620 tacagtgaca gttgacagcg acagctatca gttgctcaag gcatatatga tgtcaatatc 1680 tccggtctgg taagcacaac catgcagaat gaagcccgtc gtctgcgtgc cgaacgctgg 1740 aaagcggaaa atcaggaagg gatggctgag gtcgcccggt ttattgaaat gaacggctct 1800 tttgctgacg agaacagggg ctggtgaaat gcagtttaag gtttacacct ataaaagaga 1860 gagccgttat cgtctgtttg tggatgtaca gagtgatatt attgacacgc ccgggcgacg 1920 gatggtgatc cccctggcca gtgcacgtct gctgtcagat aaagtctccc gtgaacttta 1980 cccggtggtg catatcgggg atgaaagctg gcgcatgatg accaccgata tggccagtgt 2040 gccggtctcc gttatcgggg aagaagtggc tgatctcagc caccgcgaaa atgacatcaa 2100 aaacgccatt aacctgatgt tctggggaat ataaatgtca ggctccctta tacacagcca 2160 gtctgcaggt cgaccatagt gactggatat gttgtgtttt acagtattat gtagtctgtt 2220 ttttatgcaa aatctaattt aatatattga tatttatatc attttacgtt tctcgttcag 2280 ctttcttgta caaagtggtt ggtaagccta tccctaaccc tctcctcggt ctcgattcta 2340 cgtagtaatg agctagcagt ctcgaggtta acgaattccg ccccccccct aacgttactg 2400 gccgaagccg cttggaataa ggccggtgtg cgcttgtcta tatgttattt tccaccatat 2460 tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc 2520 ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag 2580 cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc 2640 ggaacccccc acctggcgac aggtgcccct gcggccaaaa gccacgtgta taagatacac 2700 ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca 2760 aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt 2820 gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa 2880 aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgataat 2940 accatggcca tgattaagat cgctacgcgg aagtacctgg ggaaacagaa cgtctacgac 3000 ataggtgtgg agcgcgatca caactttgct ctgaaaaatg gatttatcgc cagcaactgc 3060 ttgccgaata tcatggtgga aaatggccgc ttttctggat tcatcgactg tggccggctg 3120 ggtgtggcgg accgctatca ggacatagcg ttggctaccc gtgatattgc tgaagagctt 3180 ggcggcgaat gggctgaccg cttcctcgtg ctttacggta tcgccgctcc cgattcgcag 3240 cgcatcgcct tctatcgcct tcttgacgag ttcttctgag aattcaccgg tggcgcgtta 3300 agtcgacaat caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta 3360 tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc 3420 ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga 3480 ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac 3540 ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc 3600 cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc 3660 tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt cctttccttg 3720 gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc 3780 ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc 3840 gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcgtcg 3900 actttaagac caatgactta caaggcagct gtagatctta gccacttttt aaaagaaaag 3960 gggggactgg aagggctaat tcactcccaa cgaagacaag atctgctttt tgcttgtact 4020 gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca 4080 ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg 4140 tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc 4200 agtacgtata gtagttcatg tcatcttatt attcagtatt tataacttgc aaagaaatga 4260 atatcagaga gtgagaggaa cttgtttatt gcagcttata atggttacaa ataaagcaat 4320 agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc 4380 aaactcatca atgtatctta tcatgtctgg ctctagctat cccgccccta actccgccca 4440 tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt 4500 ttatttatgc agaggccgag gccgcctcgg cctctgagct attccagaag tagtgaggag 4560 gcttttttgg aggcctaggg acgtacccaa ttcgccctat agtgagtcgt attacgcgcg 4620 ctcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa 4680 tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg cccgcaccga 4740 tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc 4800 attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct 4860 agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg 4920 tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga 4980 ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt 5040 ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg 5100 aacaacactc aaccctatct cggtctattc ttttgattta taagggattt tgccgatttc 5160 ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt ttaacaaaat 5220 attaacgctt acaatttagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt 5280 ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg 5340 cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt 5400 cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta 5460 aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc 5520 ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa 5580 gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc 5640 cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt 5700 acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact 5760 gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac 5820 aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata 5880 ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta 5940 ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg 6000 gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat 6060 aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt 6120 aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga 6180 aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa 6240 gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag 6300 gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac 6360 tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc 6420 gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat 6480 caagagctac caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat 6540 actgttcttc tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct 6600 acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt 6660 cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg 6720 gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta 6780 cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg 6840 gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg 6900 tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc 6960 tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg 7020 gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat 7080 aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc 7140 agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc tctccccgcg 7200 cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa agcgggcagt 7260 gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc tttacacttt 7320 atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca cacaggaaac 7380 agctatgacc atgattacgc caagcgcgca attaaccctc actaaaggga acaaaagctg 7440 gagctgcaag cttaatgtag tcttatgcaa tactcttgta gtcttgcaac atggtaacga 7500 tgagttagca acatgcctta caaggagaga aaaagcaccg tgcatgccga ttggtggaag 7560 taaggtggta cgatcgtgcc ttattaggaa ggcaacagac gggtctgaca tggattggac 7620 gaaccactga attgccgcat tgcagagata ttgtatttaa gtgcctagct cgatacataa 7680 acgggtctct ctggttagac cagatctgag cctgggagct ctctggctaa ctagggaacc 7740 cactgcttaa gcctcaataa agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt 7800 tgtgtgactc tggtaactag agatccctca gaccctttta gtcagtgtgg aaaatctcta 7860 gcagtggcgc ccgaacaggg acttgaaagc gaaagggaaa ccagaggagc tctctcgacg 7920 caggactcgg cttgctgaag cgcgcacggc aagaggcgag gggcggcgac tggtgagtac 7980 gccaaaaatt ttgactagcg gaggctagaa ggagagagat gggtgcgaga gcgtcagtat 8040 taagcggggg agaattagat cgcgatggga aaaaattcgg ttaaggccag ggggaaagaa 8100 aaaatataaa ttaaaacata tagtatgggc aagcagggag ctagaacgat tcgcagttaa 8160 tcctggcctg ttagaaacat cagaaggctg tagacaaata ctgggacagc tacaaccatc 8220 ccttcagaca ggatcagaag aacttagatc attatataat acagtagcaa ccctctattg 8280 tgtgcatcaa aggatagaga taaaagacac caaggaagct ttagacaaga tagaggaaga 8340 gcaaaacaaa agtaagacca ccgcacagca agcggccgct gatcttcaga cctggaggag 8400 gagatatgag ggacaattgg agaagtgaat tatataaata taaagtagta aaaattgaac 8460 cattaggagt agcacccacc aaggcaaaga gaagagtggt gcagagagaa aaaagagcag 8520 tgggaatagg agctttgttc cttgggttct tgggagcagc aggaagcact atgggcgcag 8580 cgtcaatgac gctgacggta caggccagac aattattgtc tggtatagtg cagcagcaga 8640 acaatttgct gagggctatt gaggcgcaac agcatctgtt gcaactcaca gtctggggca 8700 tcaagcagct ccaggcaaga atcctggctg tggaaagata cctaaaggat caacagctcc 8760 tggggatttg gggttgctct ggaaaactca tttgcaccac tgctgtgcct tggaatgcta 8820 gttggagtaa taaatctctg gaacagattt ggaatcacac gacctggatg gagtgggaca 8880 gagaaattaa caattacaca agcttaatac actccttaat tgaagaatcg caaaaccagc 8940 aagaaaagaa tgaacaagaa ttattggaat tagataaatg ggcaagtttg tggaattggt 9000 ttaacataac aaattggctg tggtatataa aattattcat aatgatagta ggaggcttgg 9060 taggtttaag aatagttttt gctgtacttt ctatagtgaa tagagttagg cagggatatt 9120 caccattatc gtttcagacc cacctcccaa ccccgagggg acccttgcgc cttttccaag 9180 gcagccctgg gtttgcgcag ggacgcggct gctctgggcg tggttccggg aaacgcagcg 9240 gcgccgaccc tgggtctcgc acattcttca cgtccgttcg cagcgtcacc cggatcttcg 9300 ccgctaccct tgtgggcccc ccggcgacgc ttcctgctcc gcccctaagt cgggaaggtt 9360 ccttgcggtt cgcggcgtgc cggacgtgac aaacggaagc cgcacgtctc actagtaccc 9420 tcgcagacgg acagcgccag ggagcaatgg cagcgcgccg accgcgatgg gctgtggcca 9480 atagcggctg ctcagcaggg cgcgccgaga gcagcggccg ggaaggggcg gtgcgggagg 9540 cggggtgtgg ggcggtagtg tgggccctgt tcctgcccgc gcggtgttcc gcattctgca 9600 agcctccgga gcgcacgtcg gcagtcggct ccctcgttga ccgaatcacc gacctctctc 9660 cccagggggt acccagctgt ctagagaatt ctagatcttg agacaaatgg cagtattcat 9720 ccacaatttt aaaagaaaag gggggattgg ggggtacagt gcaggggaaa gaatagtaga 9780 cataatagca acagacatac aaactaaaga attacaaaaa caaattacaa aaattcaaaa 9840 ttttcgggtt tattacaggg acagcagaga tccactttgg cgccggctcg aggggg 9896 <210> 117 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 117 Met Ala Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn 1 5 10 15 Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn 20 25 30 Gly Phe Ile Ala Ser Asn Cys Leu Pro Asn Ile Met Val Glu Asn Gly 35 40 45 Arg Phe Ser Gly Phe Ile Asp Cys Gly Arg Leu Gly Val Ala Asp Arg 50 55 60 Tyr Gln Asp Ile Ala Leu Ala Thr Arg Asp Ile Ala Glu Glu Leu Gly 65 70 75 80 Gly Glu Trp Ala Asp Arg Phe Leu Val Leu Tyr Gly Ile Ala Ala Pro 85 90 95 Asp Ser Gln Arg Ile Ala Phe Tyr Arg Leu Leu Asp Glu Phe Phe 100 105 110 <210> 118 <211> 9536 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 118 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgagcga gctgattaag 660 gagaacatgc acatgaagct gtacatggag ggcaccgtgg acaaccatca cttcaagtgc 720 acatccgagg gcgaaggcaa gccctacgag ggcacccaga ccatgagaat caaggtggtc 780 gagggcggcc ctctcccctt cgccttcgac atcctggcta ctagcttcct ctacggcagc 840 aagaccttca tcaaccacac ccagggcatc cccgacttct tcaagcagtc cttccctgag 900 ggcttcacat gggagagagt caccacatac gaagacgggg gcgtgctgac cgctacccag 960 gacaccagcc tccaggacgg ctgcctcatc tacaacgtca agatcagagg ggtgaacttc 1020 acatccaacg gccctgtgat gcagaagaaa acactcggct gggaggcctt caccgagacg 1080 ctgtaccccg ctgacggcgg cctggaaggc agaaacgaca tggccctgaa gctcgtgggc 1140 gggagccatc tgatcgcaaa catcaagacc acatatagat ccaagaaacc cgctaagaac 1200 ctcaagatgc ctggcgtcta ctatgtggac tacagactgg aaagaatcaa ggaggccaac 1260 aacgagacct acgtcgagca gcacgaggtg gcagtggcca gatactgcga cctccctagc 1320 aaactggggc acaagcttaa ttaattaatt aagaattcga cccagctttc ttgtacaaag 1380 tggttggtaa gcctatccct aaccctctcc tcggtctcga ttctacgtag taatgagcta 1440 gcagtctcga ggttaacgaa ttccgccccc cccctaacgt tactggccga agccgcttgg 1500 aataaggccg gtgtgcgctt gtctatatgt tattttccac catattgccg tcttttggca 1560 atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg ggtctttccc 1620 ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt cctctggaag 1680 cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac cccccacctg 1740 gcgacaggtg cccctgcggc caaaagccac gtgtataaga tacacctgca aaggcggcac 1800 aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg ctctcctcaa 1860 gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg ggatctgatc 1920 tggggcctcg gtgcacatgc tttacatgtg tttagtcgag gttaaaaaaa cgtctaggcc 1980 ccccgaacca cggggacgtg gttttccttt gaaaaacacg ataataccat gggatcggcc 2040 attgaacaag atggattgca cgcaggttct ccggccgctt gggtggagag gctattcggc 2100 tatgactggg cacaacagac aatcggctgc tctgatgccg ccgtgttccg gctgtcagcg 2160 caggggcgcc cggttctttt tgtcaagacc gacctgtccg gtgccctgaa tgaactgcag 2220 gacgaggcag cgcggctatc gtggctggcc acgacgggcg ttccttgcgc agctgtgctc 2280 gacgttgtca ctgaagcggg aagggactgg ctgctattgg gcgaagtgcc ggggcaggat 2340 ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca tcatggctga tgcaatgcgg 2400 cggctgcata cgcttgatcc ggctacctgc ccattcgacc accaagcgaa acatcgcatc 2460 gagcgagcac gtactcggat ggaagccggt cttgtcgatc aggatgatct ggacgaagag 2520 catcaggggc tcgcgccagc cgaactgttc gccaggctca aggcgcgcat gcccgacggc 2580 gatgatctcg tcgtgaccca tggcgatgcc tgcctttcat acgagaccga gatcctgact 2640 gtcgagtacg gattgcttcc tatcggcaaa atcgtggaga agaggattga atgtaccgtc 2700 tattcagtcg ataataatgg gaacatctac acacagcccg tggctcaatg gcacgacaga 2760 ggagagcagg aagtttttga atactgtctc gaggacggat ccctcatccg cgctactaaa 2820 gatcataagt ttatgaccgt ggacggccag atgctgccaa ttgacgaaat ttttgaacga 2880 gagctggatc tgatgagagt cgacaacctt ccaaactgag aattcaccgg tggcgcgtta 2940 agtcgacaat caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta 3000 tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc 3060 ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga 3120 ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac 3180 ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc 3240 cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc 3300 tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt cctttccttg 3360 gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc 3420 ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc 3480 gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcgtcg 3540 actttaagac caatgactta caaggcagct gtagatctta gccacttttt aaaagaaaag 3600 gggggactgg aagggctaat tcactcccaa cgaagacaag atctgctttt tgcttgtact 3660 gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca 3720 ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg 3780 tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc 3840 agtacgtata gtagttcatg tcatcttatt attcagtatt tataacttgc aaagaaatga 3900 atatcagaga gtgagaggaa cttgtttatt gcagcttata atggttacaa ataaagcaat 3960 agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc 4020 aaactcatca atgtatctta tcatgtctgg ctctagctat cccgccccta actccgccca 4080 tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt 4140 ttatttatgc agaggccgag gccgcctcgg cctctgagct attccagaag tagtgaggag 4200 gcttttttgg aggcctaggg acgtacccaa ttcgccctat agtgagtcgt attacgcgcg 4260 ctcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa 4320 tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg cccgcaccga 4380 tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc 4440 attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct 4500 agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg 4560 tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga 4620 ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt 4680 ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg 4740 aacaacactc aaccctatct cggtctattc ttttgattta taagggattt tgccgatttc 4800 ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt ttaacaaaat 4860 attaacgctt acaatttagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt 4920 ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg 4980 cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt 5040 cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta 5100 aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc 5160 ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa 5220 gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc 5280 cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt 5340 acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact 5400 gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac 5460 aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata 5520 ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta 5580 ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg 5640 gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat 5700 aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt 5760 aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga 5820 aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa 5880 gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag 5940 gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac 6000 tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc 6060 gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat 6120 caagagctac caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat 6180 actgttcttc tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct 6240 acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt 6300 cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg 6360 gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta 6420 cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg 6480 gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg 6540 tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc 6600 tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg 6660 gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat 6720 aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc 6780 agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc tctccccgcg 6840 cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa agcgggcagt 6900 gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc tttacacttt 6960 atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca cacaggaaac 7020 agctatgacc atgattacgc caagcgcgca attaaccctc actaaaggga acaaaagctg 7080 gagctgcaag cttaatgtag tcttatgcaa tactcttgta gtcttgcaac atggtaacga 7140 tgagttagca acatgcctta caaggagaga aaaagcaccg tgcatgccga ttggtggaag 7200 taaggtggta cgatcgtgcc ttattaggaa ggcaacagac gggtctgaca tggattggac 7260 gaaccactga attgccgcat tgcagagata ttgtatttaa gtgcctagct cgatacataa 7320 acgggtctct ctggttagac cagatctgag cctgggagct ctctggctaa ctagggaacc 7380 cactgcttaa gcctcaataa agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt 7440 tgtgtgactc tggtaactag agatccctca gaccctttta gtcagtgtgg aaaatctcta 7500 gcagtggcgc ccgaacaggg acttgaaagc gaaagggaaa ccagaggagc tctctcgacg 7560 caggactcgg cttgctgaag cgcgcacggc aagaggcgag gggcggcgac tggtgagtac 7620 gccaaaaatt ttgactagcg gaggctagaa ggagagagat gggtgcgaga gcgtcagtat 7680 taagcggggg agaattagat cgcgatggga aaaaattcgg ttaaggccag ggggaaagaa 7740 aaaatataaa ttaaaacata tagtatgggc aagcagggag ctagaacgat tcgcagttaa 7800 tcctggcctg ttagaaacat cagaaggctg tagacaaata ctgggacagc tacaaccatc 7860 ccttcagaca ggatcagaag aacttagatc attatataat acagtagcaa ccctctattg 7920 tgtgcatcaa aggatagaga taaaagacac caaggaagct ttagacaaga tagaggaaga 7980 gcaaaacaaa agtaagacca ccgcacagca agcggccgct gatcttcaga cctggaggag 8040 gagatatgag ggacaattgg agaagtgaat tatataaata taaagtagta aaaattgaac 8100 cattaggagt agcacccacc aaggcaaaga gaagagtggt gcagagagaa aaaagagcag 8160 tgggaatagg agctttgttc cttgggttct tgggagcagc aggaagcact atgggcgcag 8220 cgtcaatgac gctgacggta caggccagac aattattgtc tggtatagtg cagcagcaga 8280 acaatttgct gagggctatt gaggcgcaac agcatctgtt gcaactcaca gtctggggca 8340 tcaagcagct ccaggcaaga atcctggctg tggaaagata cctaaaggat caacagctcc 8400 tggggatttg gggttgctct ggaaaactca tttgcaccac tgctgtgcct tggaatgcta 8460 gttggagtaa taaatctctg gaacagattt ggaatcacac gacctggatg gagtgggaca 8520 gagaaattaa caattacaca agcttaatac actccttaat tgaagaatcg caaaaccagc 8580 aagaaaagaa tgaacaagaa ttattggaat tagataaatg ggcaagtttg tggaattggt 8640 ttaacataac aaattggctg tggtatataa aattattcat aatgatagta ggaggcttgg 8700 taggtttaag aatagttttt gctgtacttt ctatagtgaa tagagttagg cagggatatt 8760 caccattatc gtttcagacc cacctcccaa ccccgagggg acccttgcgc cttttccaag 8820 gcagccctgg gtttgcgcag ggacgcggct gctctgggcg tggttccggg aaacgcagcg 8880 gcgccgaccc tgggtctcgc acattcttca cgtccgttcg cagcgtcacc cggatcttcg 8940 ccgctaccct tgtgggcccc ccggcgacgc ttcctgctcc gcccctaagt cgggaaggtt 9000 ccttgcggtt cgcggcgtgc cggacgtgac aaacggaagc cgcacgtctc actagtaccc 9060 tcgcagacgg acagcgccag ggagcaatgg cagcgcgccg accgcgatgg gctgtggcca 9120 atagcggctg ctcagcaggg cgcgccgaga gcagcggccg ggaaggggcg gtgcgggagg 9180 cggggtgtgg ggcggtagtg tgggccctgt tcctgcccgc gcggtgttcc gcattctgca 9240 agcctccgga gcgcacgtcg gcagtcggct ccctcgttga ccgaatcacc gacctctctc 9300 cccagggggt acccagctgt ctagagaatt ctagatcttg agacaaatgg cagtattcat 9360 ccacaatttt aaaagaaaag gggggattgg ggggtacagt gcaggggaaa gaatagtaga 9420 cataatagca acagacatac aaactaaaga attacaaaaa caaattacaa aaattcaaaa 9480 ttttcgggtt tattacaggg acagcagaga tccactttgg cgccggctcg aggggg 9536 <210> 119 <211> 8990 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 119 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggtgag caagggcgag 660 gaggataaca tggccatcat caaggagttc atgcgcttca aggtgcacat ggagggctcc 720 gtgaacggcc acgagttcga gatcgagggc gagggcgagg gccgccccta cgagggcacc 780 cagaccgcca agctgaaggt gaccaagggt ggccccctgc ccttcgcctg ggacatcctg 840 tcccctcagt tcatgtacgg ctccaaggcc tacgtgaagc accccgccga catccccgac 900 tacttgaagc tgtccttccc cgagggcttc aagtgggagc gcgtgatgaa cttcgaggac 960 ggcggcgtgg tgaccgtgac ccaggactcc tccctgcagg acggcgagtt catctacaag 1020 gtgaagctgc gcggcaccaa cttcccctcc gacggccccg taatgcagaa gaagaccatg 1080 ggctgggagg cctcctccga gcggatgtac cccgaggacg gcgccctgaa gggcgagatc 1140 aagcagaggc tgaagctgaa ggacggcggc cactacgacg ctgaggtcaa gaccacctac 1200 aaggccaaga agcccgtgca gctgcccggc gcctacaacg tcaacattaa gttggacatc 1260 acctcccaca acgaggacta caccatcgtg gaacagtacg aacgcgccga gggccgccac 1320 tccaccggcg gcatggacga gctgtacaag tgattaatta agaattcgac ccagctttct 1380 tgtacaaagt ggttggtaag cctatcccta accctctcct cggtctcgat tctacgtagt 1440 aatgagctag cagtctcgag gttaacgaat tccgcccccc ccctaacgtt actggccgaa 1500 gccgcttgga ataaggccgg tgtgcgcttg tctatatgtt attttccacc atattgccgt 1560 cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg 1620 gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc 1680 ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc 1740 ccccacctgg cgacaggtgc ccctgcggcc aaaagccacg tgtataagat acacctgcaa 1800 aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc 1860 tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg 1920 gatctgatct ggggcctcgg tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaaac 1980 gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga taataccatg 2040 gccatgatta agatcgctac gcggaagtac ctggggaaac agaacgtcta cgacataggt 2100 gtggagcgcg atcacaactt tgctctgaaa aatggattta tcgccagcaa ctgcttgccg 2160 aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg 2220 gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc 2280 gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc 2340 gccttctatc gccttcttga cgagttcttc tgagaattca ccggtggcgc gttaagtcga 2400 caatcaacct ctggattaca aaatttgtga aagattgact ggtattctta actatgttgc 2460 tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta ttgcttcccg 2520 tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt atgaggagtt 2580 gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg caacccccac 2640 tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt tccccctccc 2700 tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag gggctcggct 2760 gttgggcact gacaattccg tggtgttgtc ggggaaatca tcgtcctttc cttggctgct 2820 cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct 2880 caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc ttccgcgtct 2940 tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc gtcgacttta 3000 agaccaatga cttacaaggc agctgtagat cttagccact ttttaaaaga aaagggggga 3060 ctggaagggc taattcactc ccaacgaaga caagatctgc tttttgcttg tactgggtct 3120 ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt 3180 aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac 3240 tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtacg 3300 tatagtagtt catgtcatct tattattcag tatttataac ttgcaaagaa atgaatatca 3360 gagagtgaga ggaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc 3420 acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc 3480 atcaatgtat cttatcatgt ctggctctag ctatcccgcc cctaactccg cccatcccgc 3540 ccctaactcc gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt 3600 atgcagaggc cgaggccgcc tcggcctctg agctattcca gaagtagtga ggaggctttt 3660 ttggaggcct agggacgtac ccaattcgcc ctatagtgag tcgtattacg cgcgctcact 3720 ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct 3780 tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc 3840 ttcccaacag ttgcgcagcc tgaatggcga atgggacgcg ccctgtagcg gcgcattaag 3900 cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc 3960 cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc 4020 tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa 4080 aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg 4140 ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac 4200 actcaaccct atctcggtct attcttttga tttataaggg attttgccga tttcggccta 4260 ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac 4320 gcttacaatt taggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt 4380 ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa 4440 taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt 4500 tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat 4560 gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag 4620 atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg 4680 ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata 4740 cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat 4800 ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc 4860 aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg 4920 ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac 4980 gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact 5040 ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa 5100 gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct 5160 ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc 5220 tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga 5280 cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac 5340 tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag 5400 atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg 5460 tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc 5520 tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag 5580 ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtt 5640 cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac 5700 ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc 5760 gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt 5820 tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt 5880 gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc 5940 ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt 6000 tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca 6060 ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt 6120 tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt 6180 attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag 6240 tcagtgagcg aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg 6300 ccgattcatt aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc 6360 aacgcaatta atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt 6420 ccggctcgta tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat 6480 gaccatgatt acgccaagcg cgcaattaac cctcactaaa gggaacaaaa gctggagctg 6540 caagcttaat gtagtcttat gcaatactct tgtagtcttg caacatggta acgatgagtt 6600 agcaacatgc cttacaagga gagaaaaagc accgtgcatg ccgattggtg gaagtaaggt 6660 ggtacgatcg tgccttatta ggaaggcaac agacgggtct gacatggatt ggacgaacca 6720 ctgaattgcc gcattgcaga gatattgtat ttaagtgcct agctcgatac ataaacgggt 6780 ctctctggtt agaccagatc tgagcctggg agctctctgg ctaactaggg aacccactgc 6840 ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg 6900 actctggtaa ctagagatcc ctcagaccct tttagtcagt gtggaaaatc tctagcagtg 6960 gcgcccgaac agggacttga aagcgaaagg gaaaccagag gagctctctc gacgcaggac 7020 tcggcttgct gaagcgcgca cggcaagagg cgaggggcgg cgactggtga gtacgccaaa 7080 aattttgact agcggaggct agaaggagag agatgggtgc gagagcgtca gtattaagcg 7140 ggggagaatt agatcgcgat gggaaaaaat tcggttaagg ccagggggaa agaaaaaata 7200 taaattaaaa catatagtat gggcaagcag ggagctagaa cgattcgcag ttaatcctgg 7260 cctgttagaa acatcagaag gctgtagaca aatactggga cagctacaac catcccttca 7320 gacaggatca gaagaactta gatcattata taatacagta gcaaccctct attgtgtgca 7380 tcaaaggata gagataaaag acaccaagga agctttagac aagatagagg aagagcaaaa 7440 caaaagtaag accaccgcac agcaagcggc cgctgatctt cagacctgga ggaggagata 7500 tgagggacaa ttggagaagt gaattatata aatataaagt agtaaaaatt gaaccattag 7560 gagtagcacc caccaaggca aagagaagag tggtgcagag agaaaaaaga gcagtgggaa 7620 taggagcttt gttccttggg ttcttgggag cagcaggaag cactatgggc gcagcgtcaa 7680 tgacgctgac ggtacaggcc agacaattat tgtctggtat agtgcagcag cagaacaatt 7740 tgctgagggc tattgaggcg caacagcatc tgttgcaact cacagtctgg ggcatcaagc 7800 agctccaggc aagaatcctg gctgtggaaa gatacctaaa ggatcaacag ctcctgggga 7860 tttggggttg ctctggaaaa ctcatttgca ccactgctgt gccttggaat gctagttgga 7920 gtaataaatc tctggaacag atttggaatc acacgacctg gatggagtgg gacagagaaa 7980 ttaacaatta cacaagctta atacactcct taattgaaga atcgcaaaac cagcaagaaa 8040 agaatgaaca agaattattg gaattagata aatgggcaag tttgtggaat tggtttaaca 8100 taacaaattg gctgtggtat ataaaattat tcataatgat agtaggaggc ttggtaggtt 8160 taagaatagt ttttgctgta ctttctatag tgaatagagt taggcaggga tattcaccat 8220 tatcgtttca gacccacctc ccaaccccga ggggaccctt gcgccttttc caaggcagcc 8280 ctgggtttgc gcagggacgc ggctgctctg ggcgtggttc cgggaaacgc agcggcgccg 8340 accctgggtc tcgcacattc ttcacgtccg ttcgcagcgt cacccggatc ttcgccgcta 8400 cccttgtggg ccccccggcg acgcttcctg ctccgcccct aagtcgggaa ggttccttgc 8460 ggttcgcggc gtgccggacg tgacaaacgg aagccgcacg tctcactagt accctcgcag 8520 acggacagcg ccagggagca atggcagcgc gccgaccgcg atgggctgtg gccaatagcg 8580 gctgctcagc agggcgcgcc gagagcagcg gccgggaagg ggcggtgcgg gaggcggggt 8640 gtggggcggt agtgtgggcc ctgttcctgc ccgcgcggtg ttccgcattc tgcaagcctc 8700 cggagcgcac gtcggcagtc ggctccctcg ttgaccgaat caccgacctc tctccccagg 8760 gggtacccag ctgtctagag aattctagat cttgagacaa atggcagtat tcatccacaa 8820 ttttaaaaga aaagggggga ttggggggta cagtgcaggg gaaagaatag tagacataat 8880 agcaacagac atacaaacta aagaattaca aaaacaaatt acaaaaattc aaaattttcg 8940 ggtttattac agggacagca gagatccact ttggcgccgg ctcgaggggg 8990 <210> 120 <211> 9219 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 120 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggtgag caagggcgag 660 gcagtgatca aggagttcat gcggttcaag gtgcacatgg agggctccat gaacggccac 720 gagttcgaga tcgagggcga gggcgagggc cgcccctacg agggcaccca gaccgccaag 780 ctgaaggtga ccaagtgcct ttcatacgag accgagatcc tgactgtcga gtacggattg 840 cttcctatcg gcaaaatcgt ggagaagagg attgaatgta ccgtctattc agtcgataat 900 aatgggaaca tctacacaca gcccgtggct caatggcacg acagaggaga gcaggaagtt 960 tttgaatact gtctcgagga cggatccctc atccgcgcta ctaaagatca taagtttatg 1020 accgtggacg gccagatgct gccaattgac gaaatttttg aacgagagct ggatctgatg 1080 agagtcgaca accttccaaa cggtggaggg gggtcaggct ctgcgcagct ggaaaaggag 1140 cttcaagccc tcgaaaaaaa gttggcccag ctcgagtggg agaaccaggc tctggagaaa 1200 gaactggccc agtgattaat taagaattcg acccagcttt cttgtacaaa gtggttggta 1260 agcctatccc taaccctctc ctcggtctcg attctacgta gtaatgagct agcagtctcg 1320 aggttaacga attccgcccc ccccctaacg ttactggccg aagccgcttg gaataaggcc 1380 ggtgtgcgct tgtctatatg ttattttcca ccatattgcc gtcttttggc aatgtgaggg 1440 cccggaaacc tggccctgtc ttcttgacga gcattcctag gggtctttcc cctctcgcca 1500 aaggaatgca aggtctgttg aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa 1560 gacaaacaac gtctgtagcg accctttgca ggcagcggaa ccccccacct ggcgacaggt 1620 gcccctgcgg ccaaaagcca cgtgtataag atacacctgc aaaggcggca caaccccagt 1680 gccacgttgt gagttggata gttgtggaaa gagtcaaatg gctctcctca agcgtattca 1740 acaaggggct gaaggatgcc cagaaggtac cccattgtat gggatctgat ctggggcctc 1800 ggtgcacatg ctttacatgt gtttagtcga ggttaaaaaa acgtctaggc cccccgaacc 1860 acggggacgt ggttttcctt tgaaaaacac gataatacca tggccatgag cgagctgatt 1920 aaggagaaca tgcacatgaa gctgtacatg gagggcaccg tggacaacca tcacttcaag 1980 tgcacatccg agggcgaagg caagccctac gagggcaccc agaccatgag aatcaaggtg 2040 gtcgagggcg gccctctccc cttcgccttc gacatcctgg ctactagctt cctctacggc 2100 agcaagacct tcatcaacca cacccagggc atccccgact tcttcaagca gtccttccct 2160 gagggcttca catgggagag agtcaccaca tacgaagacg ggggcgtgct gaccgctacc 2220 caggacacca gcctccagga cggctgcctc atctacaacg tcaagatcag aggggtgaac 2280 ttcacatcca acggccctgt gatgcagaag aaaacactcg gctgggaggc cttcaccgag 2340 acgctgtacc ccgctgacgg cggcctggaa ggcagaaacg acatggccct gaagctcgtg 2400 ggcgggagcc atctgatcgc aaacatcaag accacatata gatccaagaa acccgctaag 2460 aacctcaaga tgcctggcgt ctactatgtg gactacagac tggaaagaat caaggaggcc 2520 aacaacgaga cctacgtcga gcagcacgag gtggcagtgg ccagatactg cgacctccct 2580 agcaaactgg ggcacaagct taattaacac cggtggcgcg ttaagtcgac aatcaacctc 2640 tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct ccttttacgc 2700 tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt atggctttca 2760 ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg tggcccgttg 2820 tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact ggttggggca 2880 ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct attgccacgg 2940 cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg ttgggcactg 3000 acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc gcctgtgttg 3060 ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc aatccagcgg 3120 accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc 3180 ctcagacgag tcggatctcc ctttgggccg cctccccgcg tcgactttaa gaccaatgac 3240 ttacaaggca gctgtagatc ttagccactt tttaaaagaa aaggggggac tggaagggct 3300 aattcactcc caacgaagac aagatctgct ttttgcttgt actgggtctc tctggttaga 3360 ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata 3420 aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta 3480 gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagtacgt atagtagttc 3540 atgtcatctt attattcagt atttataact tgcaaagaaa tgaatatcag agagtgagag 3600 gaacttgttt attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac 3660 aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc 3720 ttatcatgtc tggctctagc tatcccgccc ctaactccgc ccatcccgcc cctaactccg 3780 cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc 3840 gaggccgcct cggcctctga gctattccag aagtagtgag gaggcttttt tggaggccta 3900 gggacgtacc caattcgccc tatagtgagt cgtattacgc gcgctcactg gccgtcgttt 3960 tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc 4020 cccctttcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt 4080 tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 4140 tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 4200 ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 4260 ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 4320 agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 4380 tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 4440 tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 4500 atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 4560 aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca 4620 ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa 4680 aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt 4740 ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca 4800 gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag 4860 ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc 4920 ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca 4980 gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt 5040 aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct 5100 gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt 5160 aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga 5220 caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact 5280 tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc 5340 acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga 5400 gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt 5460 agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga 5520 gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact 5580 ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga 5640 taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt 5700 agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca 5760 aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct 5820 ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc ttctagtgta 5880 gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct 5940 aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc 6000 aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca 6060 gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga 6120 aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg 6180 aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt 6240 cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag 6300 cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt 6360 tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt 6420 tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga 6480 ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta 6540 atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa 6600 tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcgtat 6660 gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta 6720 cgccaagcgc gcaattaacc ctcactaaag ggaacaaaag ctggagctgc aagcttaatg 6780 tagtcttatg caatactctt gtagtcttgc aacatggtaa cgatgagtta gcaacatgcc 6840 ttacaaggag agaaaaagca ccgtgcatgc cgattggtgg aagtaaggtg gtacgatcgt 6900 gccttattag gaaggcaaca gacgggtctg acatggattg gacgaaccac tgaattgccg 6960 cattgcagag atattgtatt taagtgccta gctcgataca taaacgggtc tctctggtta 7020 gaccagatct gagcctggga gctctctggc taactaggga acccactgct taagcctcaa 7080 taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac 7140 tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg cgcccgaaca 7200 gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact cggcttgctg 7260 aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa attttgacta 7320 gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg gggagaatta 7380 gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat aaattaaaac 7440 atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc ctgttagaaa 7500 catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag acaggatcag 7560 aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat caaaggatag 7620 agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac aaaagtaaga 7680 ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat gagggacaat 7740 tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc 7800 accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg 7860 ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg 7920 gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct 7980 attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca 8040 agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc 8100 tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct 8160 ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac 8220 acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa gaatgaacaa 8280 gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat aacaaattgg 8340 ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt aagaatagtt 8400 tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt atcgtttcag 8460 acccacctcc caaccccgag gggacccttg cgccttttcc aaggcagccc tgggtttgcg 8520 cagggacgcg gctgctctgg gcgtggttcc gggaaacgca gcggcgccga ccctgggtct 8580 cgcacattct tcacgtccgt tcgcagcgtc acccggatct tcgccgctac ccttgtgggc 8640 cccccggcga cgcttcctgc tccgccccta agtcgggaag gttccttgcg gttcgcggcg 8700 tgccggacgt gacaaacgga agccgcacgt ctcactagta ccctcgcaga cggacagcgc 8760 cagggagcaa tggcagcgcg ccgaccgcga tgggctgtgg ccaatagcgg ctgctcagca 8820 gggcgcgccg agagcagcgg ccgggaaggg gcggtgcggg aggcggggtg tggggcggta 8880 gtgtgggccc tgttcctgcc cgcgcggtgt tccgcattct gcaagcctcc ggagcgcacg 8940 tcggcagtcg gctccctcgt tgaccgaatc accgacctct ctccccaggg ggtacccagc 9000 tgtctagaga attctagatc ttgagacaaa tggcagtatt catccacaat tttaaaagaa 9060 aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca 9120 tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca 9180 gggacagcag agatccactt tggcgccggc tcgaggggg 9219 <210> 121 <211> 190 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 121 Met Val Ser Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys 1 5 10 15 Val His Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 20 25 30 Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 35 40 45 Val Thr Lys Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr 50 55 60 Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr 65 70 75 80 Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala 85 90 95 Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu 100 105 110 Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val 115 120 125 Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp 130 135 140 Leu Met Arg Val Asp Asn Leu Pro Asn Gly Gly Gly Gly Ser Gly Ser 145 150 155 160 Ala Gln Leu Glu Lys Glu Leu Gln Ala Leu Glu Lys Lys Leu Ala Gln 165 170 175 Leu Glu Trp Glu Asn Gln Ala Leu Glu Lys Glu Leu Ala Gln 180 185 190 <210> 122 <211> 9639 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 122 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggctca actgaagaag 660 aaactccagg ccaataagaa agaactggca cagctgaagt ggaagctgca ggcactgaaa 720 aagaagctgg cacagggcgg aggaggctca ggcagtatga ttaagatcgc tacgcggaag 780 tacctgggga aacagaacgt ctacgacata ggtgtggagc gcgatcacaa ctttgctctg 840 aaaaatggat ttatcgccag caactgcggt ggccccctgc ccttctcctg ggacatcctg 900 tcccctcagt tcatgtacgg ctccagggcc ttcaccaagc accccgccga catccccgac 960 tactataagc agtccttccc cgagggcttc aagtgggagc gcgtgatgaa cttcgaggac 1020 ggcggcgccg tgaccgtgac ccaggacacc tccctggagg acggcaccct gatctacaag 1080 gtgaagctcc gcggcaccaa cttccctcct gacggccccg taatgcagaa gaagacaatg 1140 ggctgggaag cgtccaccga gcggttgtac cccgaggacg gcgtgctgaa gggcgacatt 1200 aagtgccttt catacgagac cgagatcctg actgtcgagt acggattgct tcctatcggc 1260 aaaatcgtgg agaagaggat tgaatgtacc gtctattcag tcgataataa tgggaacatc 1320 tacacacagc ccgtggctca atggcacgac agaggagagc aggaagtttt tgaatactgt 1380 ctcgaggacg gatccctcat ccgcgctact aaagatcata agtttatgac cgtggacggc 1440 cagatgctgc caattgacga aatttttgaa cgagagctgg atctgatgag agtcgacaac 1500 cttccaaacg gtggaggggg gtcaggctct gcgcagctgg aaaaggagct tcaagccctc 1560 gaaaaaaagt tggcccagct cgagtgggag aaccaggctc tggagaaaga actggcccag 1620 tgattaatta agaattcgac ccagctttct tgtacaaagt ggttggtaag cctatcccta 1680 accctctcct cggtctcgat tctacgtagt aatgagctag cagtctcgag gttaacgaat 1740 tccgcccccc ccctaacgtt actggccgaa gccgcttgga ataaggccgg tgtgcgcttg 1800 tctatatgtt attttccacc atattgccgt cttttggcaa tgtgagggcc cggaaacctg 1860 gccctgtctt cttgacgagc attcctaggg gtctttcccc tctcgccaaa ggaatgcaag 1920 gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga caaacaacgt 1980 ctgtagcgac cctttgcagg cagcggaacc ccccacctgg cgacaggtgc ccctgcggcc 2040 aaaagccacg tgtataagat acacctgcaa aggcggcaca accccagtgc cacgttgtga 2100 gttggatagt tgtggaaaga gtcaaatggc tctcctcaag cgtattcaac aaggggctga 2160 aggatgccca gaaggtaccc cattgtatgg gatctgatct ggggcctcgg tgcacatgct 2220 ttacatgtgt ttagtcgagg ttaaaaaaac gtctaggccc cccgaaccac ggggacgtgg 2280 ttttcctttg aaaaacacga taataccatg gtgagcaagg gcgaggagct gttcaccggg 2340 gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt cagcgtgtcc 2400 ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagttcat ctgcaccacc 2460 ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc tgacctacgg cgtgcagtgc 2520 ttcagccgct accccgacca catgaagcag cacgacttct tcaagtccgc catgcccgaa 2580 ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa gacccgcgcc 2640 gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg catcgacttc 2700 aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacaacag ccacaacgtc 2760 tatatcatgg ccgacaagca gaagaacggc atcaaggtga acttcaagat ccgccacaac 2820 atcgaggacg gcagcgtgca gctcgccgac cactaccagc agaacacccc catcggcgac 2880 ggccccgtgc tgctgcccga caaccactac ctgagcaccc agtccgccct gagcaaagac 2940 cccaacgaga agcgcgatca catggtcctg ctggagttcg tgaccgccgc cgggatcact 3000 ctcggcatgg acgagctgta caagtaacac cggtggcgcg ttaagtcgac aatcaacctc 3060 tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct ccttttacgc 3120 tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt atggctttca 3180 ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg tggcccgttg 3240 tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact ggttggggca 3300 ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct attgccacgg 3360 cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg ttgggcactg 3420 acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc gcctgtgttg 3480 ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc aatccagcgg 3540 accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc 3600 ctcagacgag tcggatctcc ctttgggccg cctccccgcg tcgactttaa gaccaatgac 3660 ttacaaggca gctgtagatc ttagccactt tttaaaagaa aaggggggac tggaagggct 3720 aattcactcc caacgaagac aagatctgct ttttgcttgt actgggtctc tctggttaga 3780 ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata 3840 aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta 3900 gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagtacgt atagtagttc 3960 atgtcatctt attattcagt atttataact tgcaaagaaa tgaatatcag agagtgagag 4020 gaacttgttt attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac 4080 aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc 4140 ttatcatgtc tggctctagc tatcccgccc ctaactccgc ccatcccgcc cctaactccg 4200 cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc 4260 gaggccgcct cggcctctga gctattccag aagtagtgag gaggcttttt tggaggccta 4320 gggacgtacc caattcgccc tatagtgagt cgtattacgc gcgctcactg gccgtcgttt 4380 tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc 4440 cccctttcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt 4500 tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 4560 tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 4620 ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 4680 ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 4740 agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 4800 tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 4860 tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 4920 atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 4980 aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca 5040 ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa 5100 aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt 5160 ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca 5220 gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag 5280 ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc 5340 ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca 5400 gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt 5460 aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct 5520 gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt 5580 aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga 5640 caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact 5700 tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc 5760 acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga 5820 gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt 5880 agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga 5940 gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact 6000 ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga 6060 taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt 6120 agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca 6180 aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct 6240 ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc ttctagtgta 6300 gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct 6360 aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc 6420 aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca 6480 gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga 6540 aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg 6600 aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt 6660 cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag 6720 cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt 6780 tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt 6840 tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga 6900 ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta 6960 atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa 7020 tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcgtat 7080 gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta 7140 cgccaagcgc gcaattaacc ctcactaaag ggaacaaaag ctggagctgc aagcttaatg 7200 tagtcttatg caatactctt gtagtcttgc aacatggtaa cgatgagtta gcaacatgcc 7260 ttacaaggag agaaaaagca ccgtgcatgc cgattggtgg aagtaaggtg gtacgatcgt 7320 gccttattag gaaggcaaca gacgggtctg acatggattg gacgaaccac tgaattgccg 7380 cattgcagag atattgtatt taagtgccta gctcgataca taaacgggtc tctctggtta 7440 gaccagatct gagcctggga gctctctggc taactaggga acccactgct taagcctcaa 7500 taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac 7560 tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg cgcccgaaca 7620 gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact cggcttgctg 7680 aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa attttgacta 7740 gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg gggagaatta 7800 gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat aaattaaaac 7860 atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc ctgttagaaa 7920 catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag acaggatcag 7980 aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat caaaggatag 8040 agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac aaaagtaaga 8100 ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat gagggacaat 8160 tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc 8220 accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg 8280 ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg 8340 gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct 8400 attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca 8460 agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc 8520 tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct 8580 ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac 8640 acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa gaatgaacaa 8700 gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat aacaaattgg 8760 ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt aagaatagtt 8820 tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt atcgtttcag 8880 acccacctcc caaccccgag gggacccttg cgccttttcc aaggcagccc tgggtttgcg 8940 cagggacgcg gctgctctgg gcgtggttcc gggaaacgca gcggcgccga ccctgggtct 9000 cgcacattct tcacgtccgt tcgcagcgtc acccggatct tcgccgctac ccttgtgggc 9060 cccccggcga cgcttcctgc tccgccccta agtcgggaag gttccttgcg gttcgcggcg 9120 tgccggacgt gacaaacgga agccgcacgt ctcactagta ccctcgcaga cggacagcgc 9180 cagggagcaa tggcagcgcg ccgaccgcga tgggctgtgg ccaatagcgg ctgctcagca 9240 gggcgcgccg agagcagcgg ccgggaaggg gcggtgcggg aggcggggtg tggggcggta 9300 gtgtgggccc tgttcctgcc cgcgcggtgt tccgcattct gcaagcctcc ggagcgcacg 9360 tcggcagtcg gctccctcgt tgaccgaatc accgacctct ctccccaggg ggtacccagc 9420 tgtctagaga attctagatc ttgagacaaa tggcagtatt catccacaat tttaaaagaa 9480 aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca 9540 tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca 9600 gggacagcag agatccactt tggcgccggc tcgaggggg 9639 <210> 123 <211> 326 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 123 Met Ala Gln Leu Lys Lys Lys Leu Gln Ala Asn Lys Lys Glu Leu Ala 1 5 10 15 Gln Leu Lys Trp Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln Gly 20 25 30 Gly Gly Gly Ser Gly Ser Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu 35 40 45 Gly Lys Gln Asn Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe 50 55 60 Ala Leu Lys Asn Gly Phe Ile Ala Ser Asn Cys Gly Gly Pro Leu Pro 65 70 75 80 Phe Ser Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Arg Ala 85 90 95 Phe Thr Lys His Pro Ala Asp Ile Pro Asp Tyr Tyr Lys Gln Ser Phe 100 105 110 Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly 115 120 125 Ala Val Thr Val Thr Gln Asp Thr Ser Leu Glu Asp Gly Thr Leu Ile 130 135 140 Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Pro Asp Gly Pro Val 145 150 155 160 Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Thr Glu Arg Leu Tyr 165 170 175 Pro Glu Asp Gly Val Leu Lys Gly Asp Ile Lys Cys Leu Ser Tyr Glu 180 185 190 Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile 195 200 205 Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly 210 215 220 Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln 225 230 235 240 Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr 245 250 255 Lys Asp His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp 260 265 270 Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro 275 280 285 Asn Gly Gly Gly Gly Ser Gly Ser Ala Gln Leu Glu Lys Glu Leu Gln 290 295 300 Ala Leu Glu Lys Lys Leu Ala Gln Leu Glu Trp Glu Asn Gln Ala Leu 305 310 315 320 Glu Lys Glu Leu Ala Gln 325 <210> 124 <211> 9093 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 124 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggctca actgaagaag 660 aaactccagg ccaataagaa agaactggca cagctgaagt ggaagctgca ggcactgaaa 720 aagaagctgg cacagggcgg aggaggctca ggcagtatga ttaagatcgc tacgcggaag 780 tacctgggga aacagaacgt ctacgacata ggtgtggagc gcgatcacaa ctttgctctg 840 aaaaatggat ttatcgccag caactgcatg gccctgcgcc tgaaggacgg cggccgctac 900 ctggcggact tcaagaccac ctacaaggcc aagaagcccg tgcagatgcc cggcgcctac 960 aacgtcgacc gcaagttgga catcacctcc cacaacgagg actacaccgt ggtggaacag 1020 tacgaacgct ccgagggccg ccactccacc ggcggcatgg acgagctgta caagtgatta 1080 attaagaatt cgacccagct ttcttgtaca aagtggttgg taagcctatc cctaaccctc 1140 tcctcggtct cgattctacg tagtaatgag ctagcagtct cgaggttaac gaattccgcc 1200 ccccccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg cttgtctata 1260 tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg 1320 tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg caaggtctgt 1380 tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca acgtctgtag 1440 cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcccctgc ggccaaaagc 1500 cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga 1560 tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg ctgaaggatg 1620 cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca tgctttacat 1680 gtgtttagtc gaggttaaaa aaacgtctag gccccccgaa ccacggggac gtggttttcc 1740 tttgaaaaac acgataatac catggtgagc aagggcgagg agctgttcac cggggtggtg 1800 cccatcctgg tcgagctgga cggcgacgta aacggccaca agttcagcgt gtccggcgag 1860 ggcgagggcg atgccaccta cggcaagctg accctgaagt tcatctgcac caccggcaag 1920 ctgcccgtgc cctggcccac cctcgtgacc accctgacct acggcgtgca gtgcttcagc 1980 cgctaccccg accacatgaa gcagcacgac ttcttcaagt ccgccatgcc cgaaggctac 2040 gtccaggagc gcaccatctt cttcaaggac gacggcaact acaagacccg cgccgaggtg 2100 aagttcgagg gcgacaccct ggtgaaccgc atcgagctga agggcatcga cttcaaggag 2160 gacggcaaca tcctggggca caagctggag tacaactaca acagccacaa cgtctatatc 2220 atggccgaca agcagaagaa cggcatcaag gtgaacttca agatccgcca caacatcgag 2280 gacggcagcg tgcagctcgc cgaccactac cagcagaaca cccccatcgg cgacggcccc 2340 gtgctgctgc ccgacaacca ctacctgagc acccagtccg ccctgagcaa agaccccaac 2400 gagaagcgcg atcacatggt cctgctggag ttcgtgaccg ccgccgggat cactctcggc 2460 atggacgagc tgtacaagta acaccggtgg cgcgttaagt cgacaatcaa cctctggatt 2520 acaaaatttg tgaaagattg actggtattc ttaactatgt tgctcctttt acgctatgtg 2580 gatacgctgc tttaatgcct ttgtatcatg ctattgcttc ccgtatggct ttcattttct 2640 cctccttgta taaatcctgg ttgctgtctc tttatgagga gttgtggccc gttgtcaggc 2700 aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc cactggttgg ggcattgcca 2760 ccacctgtca gctcctttcc gggactttcg ctttccccct ccctattgcc acggcggaac 2820 tcatcgccgc ctgccttgcc cgctgctgga caggggctcg gctgttgggc actgacaatt 2880 ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct gctcgcctgt gttgccacct 2940 ggattctgcg cgggacgtcc ttctgctacg tcccttcggc cctcaatcca gcggaccttc 3000 cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg tcttcgcctt cgccctcaga 3060 cgagtcggat ctccctttgg gccgcctccc cgcgtcgact ttaagaccaa tgacttacaa 3120 ggcagctgta gatcttagcc actttttaaa agaaaagggg ggactggaag ggctaattca 3180 ctcccaacga agacaagatc tgctttttgc ttgtactggg tctctctggt tagaccagat 3240 ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc aataaagctt 3300 gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta actagagatc 3360 cctcagaccc ttttagtcag tgtggaaaat ctctagcagt acgtatagta gttcatgtca 3420 tcttattatt cagtatttat aacttgcaaa gaaatgaata tcagagagtg agaggaactt 3480 gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa 3540 agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca 3600 tgtctggctc tagctatccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt 3660 tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc 3720 gcctcggcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctagggacg 3780 tacccaattc gccctatagt gagtcgtatt acgcgcgctc actggccgtc gttttacaac 3840 gtcgtgactg ggaaaaccct ggcgttaccc aacttaatcg ccttgcagca catccccctt 3900 tcgccagctg gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa cagttgcgca 3960 gcctgaatgg cgaatgggac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg 4020 ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct 4080 tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc 4140 ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt gattagggtg 4200 atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt 4260 ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg 4320 tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta aaaaatgagc 4380 tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgcttaca atttaggtgg 4440 cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa 4500 tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa 4560 gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct 4620 tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg 4680 tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg 4740 ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt 4800 atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga 4860 cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga 4920 attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac 4980 gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg 5040 ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac 5100 gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct 5160 agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct 5220 gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg 5280 gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat 5340 ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg 5400 tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat 5460 tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct 5520 catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa 5580 gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa 5640 aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc 5700 gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag tgtagccgta 5760 gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct 5820 gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg 5880 atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag 5940 cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc 6000 cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg 6060 agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt 6120 tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg 6180 gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca 6240 catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg 6300 agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc 6360 ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag 6420 ctggcacgac aggtttcccg actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag 6480 ttagctcact cattaggcac cccaggcttt acactttatg cttccggctc gtatgttgtg 6540 tggaattgtg agcggataac aatttcacac aggaaacagc tatgaccatg attacgccaa 6600 gcgcgcaatt aaccctcact aaagggaaca aaagctggag ctgcaagctt aatgtagtct 6660 tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca tgccttacaa 6720 ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga tcgtgcctta 6780 ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt gccgcattgc 6840 agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg gttagaccag 6900 atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc tcaataaagc 6960 ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg taactagaga 7020 tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg aacagggact 7080 tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt gctgaagcgc 7140 gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg actagcggag 7200 gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga attagatcgc 7260 gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta aaacatatag 7320 tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta gaaacatcag 7380 aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga tcagaagaac 7440 ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg atagagataa 7500 aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt aagaccaccg 7560 cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga caattggaga 7620 agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc acccaccaag 7680 gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc tttgttcctt 7740 gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct gacggtacag 7800 gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag ggctattgag 7860 gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca ggcaagaatc 7920 ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg ttgctctgga 7980 aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa atctctggaa 8040 cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa ttacacaagc 8100 ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga acaagaatta 8160 ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa ttggctgtgg 8220 tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat agtttttgct 8280 gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt tcagacccac 8340 ctcccaaccc cgaggggacc cttgcgcctt ttccaaggca gccctgggtt tgcgcaggga 8400 cgcggctgct ctgggcgtgg ttccgggaaa cgcagcggcg ccgaccctgg gtctcgcaca 8460 ttcttcacgt ccgttcgcag cgtcacccgg atcttcgccg ctacccttgt gggccccccg 8520 gcgacgcttc ctgctccgcc cctaagtcgg gaaggttcct tgcggttcgc ggcgtgccgg 8580 acgtgacaaa cggaagccgc acgtctcact agtaccctcg cagacggaca gcgccaggga 8640 gcaatggcag cgcgccgacc gcgatgggct gtggccaata gcggctgctc agcagggcgc 8700 gccgagagca gcggccggga aggggcggtg cgggaggcgg ggtgtggggc ggtagtgtgg 8760 gccctgttcc tgcccgcgcg gtgttccgca ttctgcaagc ctccggagcg cacgtcggca 8820 gtcggctccc tcgttgaccg aatcaccgac ctctctcccc agggggtacc cagctgtcta 8880 gagaattcta gatcttgaga caaatggcag tattcatcca caattttaaa agaaaagggg 8940 ggattggggg gtacagtgca ggggaaagaa tagtagacat aatagcaaca gacatacaaa 9000 ctaaagaatt acaaaaacaa attacaaaaa ttcaaaattt tcgggtttat tacagggaca 9060 gcagagatcc actttggcgc cggctcgagg ggg 9093 <210> 125 <211> 144 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 125 Met Ala Gln Leu Lys Lys Lys Leu Gln Ala Asn Lys Lys Glu Leu Ala 1 5 10 15 Gln Leu Lys Trp Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln Gly 20 25 30 Gly Gly Gly Ser Gly Ser Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu 35 40 45 Gly Lys Gln Asn Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe 50 55 60 Ala Leu Lys Asn Gly Phe Ile Ala Ser Asn Cys Met Ala Leu Arg Leu 65 70 75 80 Lys Asp Gly Gly Arg Tyr Leu Ala Asp Phe Lys Thr Thr Tyr Lys Ala 85 90 95 Lys Lys Pro Val Gln Met Pro Gly Ala Tyr Asn Val Asp Arg Lys Leu 100 105 110 Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Val Val Glu Gln Tyr Glu 115 120 125 Arg Ser Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 130 135 140 <210> 126 <211> 9159 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 126 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaaaaagcc tgaactcacc 660 gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 720 ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc 780 ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt 840 gcatcgtgcc tttcatacga gaccgagatc ctgactgtcg agtacggatt gcttcctatc 900 ggcaaaatcg tggagaagag gattgaatgt accgtctatt cagtcgataa taatgggaac 960 atctacacac agcccgtggc tcaatggcac gacagaggag agcaggaagt ttttgaatac 1020 tgtctcgagg acggatccct catccgcgct actaaagatc ataagtttat gaccgtggac 1080 ggccagatgc tgccaattga cgaaattttt gaacgagagc tggatctgat gagagtcgac 1140 aaccttccaa actgattaat taagaattcg acccagcttt cttgtacaaa gtggttggta 1200 agcctatccc taaccctctc ctcggtctcg attctacgta gtaatgagct agcagtctcg 1260 aggttaacga attccgcccc ccccctaacg ttactggccg aagccgcttg gaataaggcc 1320 ggtgtgcgct tgtctatatg ttattttcca ccatattgcc gtcttttggc aatgtgaggg 1380 cccggaaacc tggccctgtc ttcttgacga gcattcctag gggtctttcc cctctcgcca 1440 aaggaatgca aggtctgttg aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa 1500 gacaaacaac gtctgtagcg accctttgca ggcagcggaa ccccccacct ggcgacaggt 1560 gcccctgcgg ccaaaagcca cgtgtataag atacacctgc aaaggcggca caaccccagt 1620 gccacgttgt gagttggata gttgtggaaa gagtcaaatg gctctcctca agcgtattca 1680 acaaggggct gaaggatgcc cagaaggtac cccattgtat gggatctgat ctggggcctc 1740 ggtgcacatg ctttacatgt gtttagtcga ggttaaaaaa acgtctaggc cccccgaacc 1800 acggggacgt ggttttcctt tgaaaaacac gataatacca tggccatgag cgagctgatt 1860 aaggagaaca tgcacatgaa gctgtacatg gagggcaccg tggacaacca tcacttcaag 1920 tgcacatccg agggcgaagg caagccctac gagggcaccc agaccatgag aatcaaggtg 1980 gtcgagggcg gccctctccc cttcgccttc gacatcctgg ctactagctt cctctacggc 2040 agcaagacct tcatcaacca cacccagggc atccccgact tcttcaagca gtccttccct 2100 gagggcttca catgggagag agtcaccaca tacgaagacg ggggcgtgct gaccgctacc 2160 caggacacca gcctccagga cggctgcctc atctacaacg tcaagatcag aggggtgaac 2220 ttcacatcca acggccctgt gatgcagaag aaaacactcg gctgggaggc cttcaccgag 2280 acgctgtacc ccgctgacgg cggcctggaa ggcagaaacg acatggccct gaagctcgtg 2340 ggcgggagcc atctgatcgc aaacatcaag accacatata gatccaagaa acccgctaag 2400 aacctcaaga tgcctggcgt ctactatgtg gactacagac tggaaagaat caaggaggcc 2460 aacaacgaga cctacgtcga gcagcacgag gtggcagtgg ccagatactg cgacctccct 2520 agcaaactgg ggcacaagct taattaacac cggtggcgcg ttaagtcgac aatcaacctc 2580 tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct ccttttacgc 2640 tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt atggctttca 2700 ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg tggcccgttg 2760 tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact ggttggggca 2820 ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct attgccacgg 2880 cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg ttgggcactg 2940 acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc gcctgtgttg 3000 ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc aatccagcgg 3060 accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc 3120 ctcagacgag tcggatctcc ctttgggccg cctccccgcg tcgactttaa gaccaatgac 3180 ttacaaggca gctgtagatc ttagccactt tttaaaagaa aaggggggac tggaagggct 3240 aattcactcc caacgaagac aagatctgct ttttgcttgt actgggtctc tctggttaga 3300 ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata 3360 aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta 3420 gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagtacgt atagtagttc 3480 atgtcatctt attattcagt atttataact tgcaaagaaa tgaatatcag agagtgagag 3540 gaacttgttt attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac 3600 aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc 3660 ttatcatgtc tggctctagc tatcccgccc ctaactccgc ccatcccgcc cctaactccg 3720 cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc 3780 gaggccgcct cggcctctga gctattccag aagtagtgag gaggcttttt tggaggccta 3840 gggacgtacc caattcgccc tatagtgagt cgtattacgc gcgctcactg gccgtcgttt 3900 tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc 3960 cccctttcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt 4020 tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 4080 tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 4140 ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 4200 ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 4260 agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 4320 tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 4380 tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 4440 atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 4500 aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca 4560 ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa 4620 aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt 4680 ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca 4740 gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag 4800 ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc 4860 ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca 4920 gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt 4980 aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct 5040 gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt 5100 aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga 5160 caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact 5220 tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc 5280 acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga 5340 gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt 5400 agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga 5460 gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact 5520 ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga 5580 taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt 5640 agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca 5700 aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct 5760 ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc ttctagtgta 5820 gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct 5880 aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc 5940 aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca 6000 gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga 6060 aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg 6120 aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt 6180 cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag 6240 cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt 6300 tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt 6360 tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga 6420 ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta 6480 atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa 6540 tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcgtat 6600 gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta 6660 cgccaagcgc gcaattaacc ctcactaaag ggaacaaaag ctggagctgc aagcttaatg 6720 tagtcttatg caatactctt gtagtcttgc aacatggtaa cgatgagtta gcaacatgcc 6780 ttacaaggag agaaaaagca ccgtgcatgc cgattggtgg aagtaaggtg gtacgatcgt 6840 gccttattag gaaggcaaca gacgggtctg acatggattg gacgaaccac tgaattgccg 6900 cattgcagag atattgtatt taagtgccta gctcgataca taaacgggtc tctctggtta 6960 gaccagatct gagcctggga gctctctggc taactaggga acccactgct taagcctcaa 7020 taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac 7080 tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg cgcccgaaca 7140 gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact cggcttgctg 7200 aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa attttgacta 7260 gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg gggagaatta 7320 gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat aaattaaaac 7380 atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc ctgttagaaa 7440 catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag acaggatcag 7500 aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat caaaggatag 7560 agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac aaaagtaaga 7620 ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat gagggacaat 7680 tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc 7740 accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg 7800 ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg 7860 gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct 7920 attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca 7980 agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc 8040 tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct 8100 ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac 8160 acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa gaatgaacaa 8220 gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat aacaaattgg 8280 ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt aagaatagtt 8340 tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt atcgtttcag 8400 acccacctcc caaccccgag gggacccttg cgccttttcc aaggcagccc tgggtttgcg 8460 cagggacgcg gctgctctgg gcgtggttcc gggaaacgca gcggcgccga ccctgggtct 8520 cgcacattct tcacgtccgt tcgcagcgtc acccggatct tcgccgctac ccttgtgggc 8580 cccccggcga cgcttcctgc tccgccccta agtcgggaag gttccttgcg gttcgcggcg 8640 tgccggacgt gacaaacgga agccgcacgt ctcactagta ccctcgcaga cggacagcgc 8700 cagggagcaa tggcagcgcg ccgaccgcga tgggctgtgg ccaatagcgg ctgctcagca 8760 gggcgcgccg agagcagcgg ccgggaaggg gcggtgcggg aggcggggtg tggggcggta 8820 gtgtgggccc tgttcctgcc cgcgcggtgt tccgcattct gcaagcctcc ggagcgcacg 8880 tcggcagtcg gctccctcgt tgaccgaatc accgacctct ctccccaggg ggtacccagc 8940 tgtctagaga attctagatc ttgagacaaa tggcagtatt catccacaat tttaaaagaa 9000 aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca 9060 tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca 9120 gggacagcag agatccactt tggcgccggc tcgaggggg 9159 <210> 127 <211> 171 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 127 Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe Leu Ile 1 5 10 15 Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 20 25 30 Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 35 40 45 Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 50 55 60 Arg His Phe Ala Ser Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val 65 70 75 80 Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu 85 90 95 Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro 100 105 110 Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys 115 120 125 Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met 130 135 140 Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu 145 150 155 160 Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn 165 170 <210> 128 <211> 9579 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 128 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcgccgcgc tcccgattcc ggaagtgctt 780 gacattgggg aatttagcga gagcctgacc tattgcatct cccgccgtgc acagggtgtc 840 acgttgcaag acctgcctga aaccgaactg cccgctgttc tgcagccggt cgcggaggcc 900 atggatgcga tcgctgcggc cgatcttagc cagacgagcg ggttcggccc attcggaccg 960 caaggaatcg gtcaatacac tacatggcgt gatttcatat gcgcgattgc tgatccccat 1020 gtgtatcact ggcaaactgt gatggacgac accgtcagtg cgtccgtcgc gcaggctctc 1080 gatgagctga tgctttgggc cgaggactgc cccgaagtcc ggcacctcgt gcacgcggat 1140 ttcggctcca acaatgtcct gacggacaat ggccgcataa cagcggtcat tgactggagc 1200 gaggcgatgt tcggggattc ccaatacgag gtcgccaaca tcttcttctg gaggccgtgg 1260 ttggcttgta tggagcagca gacgcgctac ttcgagcgga ggcatccgga gcttgcagga 1320 tcgccgcggc tccgggcgta tatgctccgc attggtcttg accaactcta tcagagcttg 1380 gttgacggca atttcgatga tgcagcttgg gcgcagggtc gatgcgacgc aatcgtccga 1440 tccggagccg ggactgtcgg gcgtacacaa atcgcccgca gaagcgcggc cgtctggacc 1500 gatggctgtg tagaagtact cgccgatagt ggaaaccgac gccccagcac tcgtccgagg 1560 gcaaaggaat agttaattaa gaattcgacc cagctttctt gtacaaagtg gttggtaagc 1620 ctatccctaa ccctctcctc ggtctcgatt ctacgtagta atgagctagc agtctcgagg 1680 ttaacgaatt ccgccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt 1740 gtgcgcttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc 1800 ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag 1860 gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac 1920 aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc 1980 cctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc 2040 acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca 2100 aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt 2160 gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg 2220 gggacgtggt tttcctttga aaaacacgat aataccatgg tgagcaaggg cgaggaggat 2280 aacatggcca tcatcaagga gttcatgcgc ttcaaggtgc acatggaggg ctccgtgaac 2340 ggccacgagt tcgagatcga gggcgagggc gagggccgcc cctacgaggg cacccagacc 2400 gccaagctga aggtgaccaa gggtggcccc ctgcccttcg cctgggacat cctgtcccct 2460 cagttcatgt acggctccaa ggcctacgtg aagcaccccg ccgacatccc cgactacttg 2520 aagctgtcct tccccgaggg cttcaagtgg gagcgcgtga tgaacttcga ggacggcggc 2580 gtggtgaccg tgacccagga ctcctccctg caggacggcg agttcatcta caaggtgaag 2640 ctgcgcggca ccaacttccc ctccgacggc cccgtaatgc agaagaagac catgggctgg 2700 gaggcctcct ccgagcggat gtaccccgag gacggcgccc tgaagggcga gatcaagcag 2760 aggctgaagc tgaaggacgg cggccactac gacgctgagg tcaagaccac ctacaaggcc 2820 aagaagcccg tgcagctgcc cggcgcctac aacgtcaaca tcaagttgga catcacctcc 2880 cacaacgagg actacaccat cgtggaacag tacgaacgcg ccgagggccg ccactccacc 2940 ggcggcatgg acgagctgta caagtaacac cggtggcgcg ttaagtcgac aatcaacctc 3000 tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct ccttttacgc 3060 tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt atggctttca 3120 ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg tggcccgttg 3180 tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact ggttggggca 3240 ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct attgccacgg 3300 cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg ttgggcactg 3360 acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc gcctgtgttg 3420 ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc aatccagcgg 3480 accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc 3540 ctcagacgag tcggatctcc ctttgggccg cctccccgcg tcgactttaa gaccaatgac 3600 ttacaaggca gctgtagatc ttagccactt tttaaaagaa aaggggggac tggaagggct 3660 aattcactcc caacgaagac aagatctgct ttttgcttgt actgggtctc tctggttaga 3720 ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata 3780 aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta 3840 gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagtacgt atagtagttc 3900 atgtcatctt attattcagt atttataact tgcaaagaaa tgaatatcag agagtgagag 3960 gaacttgttt attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac 4020 aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc 4080 ttatcatgtc tggctctagc tatcccgccc ctaactccgc ccatcccgcc cctaactccg 4140 cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc 4200 gaggccgcct cggcctctga gctattccag aagtagtgag gaggcttttt tggaggccta 4260 gggacgtacc caattcgccc tatagtgagt cgtattacgc gcgctcactg gccgtcgttt 4320 tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc 4380 cccctttcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt 4440 tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 4500 tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 4560 ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 4620 ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 4680 agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 4740 tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 4800 tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 4860 atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 4920 aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca 4980 ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa 5040 aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt 5100 ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca 5160 gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag 5220 ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc 5280 ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca 5340 gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt 5400 aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct 5460 gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt 5520 aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga 5580 caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact 5640 tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc 5700 acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga 5760 gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt 5820 agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga 5880 gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact 5940 ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga 6000 taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt 6060 agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca 6120 aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct 6180 ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc ttctagtgta 6240 gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct 6300 aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc 6360 aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca 6420 gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga 6480 aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg 6540 aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt 6600 cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag 6660 cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt 6720 tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt 6780 tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga 6840 ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta 6900 atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa 6960 tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcgtat 7020 gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta 7080 cgccaagcgc gcaattaacc ctcactaaag ggaacaaaag ctggagctgc aagcttaatg 7140 tagtcttatg caatactctt gtagtcttgc aacatggtaa cgatgagtta gcaacatgcc 7200 ttacaaggag agaaaaagca ccgtgcatgc cgattggtgg aagtaaggtg gtacgatcgt 7260 gccttattag gaaggcaaca gacgggtctg acatggattg gacgaaccac tgaattgccg 7320 cattgcagag atattgtatt taagtgccta gctcgataca taaacgggtc tctctggtta 7380 gaccagatct gagcctggga gctctctggc taactaggga acccactgct taagcctcaa 7440 taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac 7500 tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg cgcccgaaca 7560 gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact cggcttgctg 7620 aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa attttgacta 7680 gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg gggagaatta 7740 gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat aaattaaaac 7800 atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc ctgttagaaa 7860 catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag acaggatcag 7920 aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat caaaggatag 7980 agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac aaaagtaaga 8040 ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat gagggacaat 8100 tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc 8160 accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg 8220 ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg 8280 gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct 8340 attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca 8400 agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc 8460 tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct 8520 ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac 8580 acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa gaatgaacaa 8640 gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat aacaaattgg 8700 ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt aagaatagtt 8760 tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt atcgtttcag 8820 acccacctcc caaccccgag gggacccttg cgccttttcc aaggcagccc tgggtttgcg 8880 cagggacgcg gctgctctgg gcgtggttcc gggaaacgca gcggcgccga ccctgggtct 8940 cgcacattct tcacgtccgt tcgcagcgtc acccggatct tcgccgctac ccttgtgggc 9000 cccccggcga cgcttcctgc tccgccccta agtcgggaag gttccttgcg gttcgcggcg 9060 tgccggacgt gacaaacgga agccgcacgt ctcactagta ccctcgcaga cggacagcgc 9120 cagggagcaa tggcagcgcg ccgaccgcga tgggctgtgg ccaatagcgg ctgctcagca 9180 gggcgcgccg agagcagcgg ccgggaaggg gcggtgcggg aggcggggtg tggggcggta 9240 gtgtgggccc tgttcctgcc cgcgcggtgt tccgcattct gcaagcctcc ggagcgcacg 9300 tcggcagtcg gctccctcgt tgaccgaatc accgacctct ctccccaggg ggtacccagc 9360 tgtctagaga attctagatc ttgagacaaa tggcagtatt catccacaat tttaaaagaa 9420 aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca 9480 tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca 9540 gggacagcag agatccactt tggcgccggc tcgaggggg 9579 <210> 129 <211> 309 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 129 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 35 40 45 Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala Gln 50 55 60 Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu 65 70 75 80 Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser 85 90 95 Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr 100 105 110 Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr 115 120 125 His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln 130 135 140 Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg 145 150 155 160 His Leu Val His Ala Asp Phe Gly Ser Asn Asn Val Leu Thr Asp Asn 165 170 175 Gly Arg Ile Thr Ala Val Ile Asp Trp Ser Glu Ala Met Phe Gly Asp 180 185 190 Ser Gln Tyr Glu Val Ala Asn Ile Phe Phe Trp Arg Pro Trp Leu Ala 195 200 205 Cys Met Glu Gln Gln Thr Arg Tyr Phe Glu Arg Arg His Pro Glu Leu 210 215 220 Ala Gly Ser Pro Arg Leu Arg Ala Tyr Met Leu Arg Ile Gly Leu Asp 225 230 235 240 Gln Leu Tyr Gln Ser Leu Val Asp Gly Asn Phe Asp Asp Ala Ala Trp 245 250 255 Ala Gln Gly Arg Cys Asp Ala Ile Val Arg Ser Gly Ala Gly Thr Val 260 265 270 Gly Arg Thr Gln Ile Ala Arg Arg Ser Ala Ala Val Trp Thr Asp Gly 275 280 285 Cys Val Glu Val Leu Ala Asp Ser Gly Asn Arg Arg Pro Ser Thr Arg 290 295 300 Pro Arg Ala Lys Glu 305 <210> 130 <211> 9345 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 130 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaaaaagcc tgaactcacc 660 gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 720 ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc 780 ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt 840 gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaatttag cgagagcctg 900 acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa 960 ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt 1020 agccagacga gctgcctttc atacgagacc gagatcctga ctgtcgagta cggattgctt 1080 cctatcggca aaatcgtgga gaagaggatt gaatgtaccg tctattcagt cgataataat 1140 gggaacatct acacacagcc cgtggctcaa tggcacgaca gaggagagca ggaagttttt 1200 gaatactgtc tcgaggacgg atccctcatc cgcgctacta aagatcataa gtttatgacc 1260 gtggacggcc agatgctgcc aattgacgaa atttttgaac gagagctgga tctgatgaga 1320 gtcgacaacc ttccaaactg attaattaag aattcgaccc agctttcttg tacaaagtgg 1380 ttggtaagcc tatccctaac cctctcctcg gtctcgattc tacgtagtaa tgagctagca 1440 gtctcgaggt taacgaattc cgcccccccc ctaacgttac tggccgaagc cgcttggaat 1500 aaggccggtg tgcgcttgtc tatatgttat tttccaccat attgccgtct tttggcaatg 1560 tgagggcccg gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc 1620 tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt 1680 cttgaagaca aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg 1740 acaggtgccc ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac 1800 cccagtgcca cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg 1860 tattcaacaa ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg 1920 ggcctcggtg cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt ctaggccccc 1980 cgaaccacgg ggacgtggtt ttcctttgaa aaacacgata ataccatggc catgagcgag 2040 ctgattaagg agaacatgca catgaagctg tacatggagg gcaccgtgga caaccatcac 2100 ttcaagtgca catccgaggg cgaaggcaag ccctacgagg gcacccagac catgagaatc 2160 aaggtggtcg agggcggccc tctccccttc gccttcgaca tcctggctac tagcttcctc 2220 tacggcagca agaccttcat caaccacacc cagggcatcc ccgacttctt caagcagtcc 2280 ttccctgagg gcttcacatg ggagagagtc accacatacg aagacggggg cgtgctgacc 2340 gctacccagg acaccagcct ccaggacggc tgcctcatct acaacgtcaa gatcagaggg 2400 gtgaacttca catccaacgg ccctgtgatg cagaagaaaa cactcggctg ggaggccttc 2460 accgagacgc tgtaccccgc tgacggcggc ctggaaggca gaaacgacat ggccctgaag 2520 ctcgtgggcg ggagccatct gatcgcaaac atcaagacca catatagatc caagaaaccc 2580 gctaagaacc tcaagatgcc tggcgtctac tatgtggact acagactgga aagaatcaag 2640 gaggccaaca acgagaccta cgtcgagcag cacgaggtgg cagtggccag atactgcgac 2700 ctccctagca aactggggca caagcttaat taacaccggt ggcgcgttaa gtcgacaatc 2760 aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat gttgctcctt 2820 ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct tcccgtatgg 2880 ctttcatttt ctcctccttg tataaatcct ggttgctgtc tctttatgag gagttgtggc 2940 ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc cccactggtt 3000 ggggcattgc caccacctgt cagctccttt ccgggacttt cgctttcccc ctccctattg 3060 ccacggcgga actcatcgcc gcctgccttg cccgctgctg gacaggggct cggctgttgg 3120 gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc ctttccttgg ctgctcgcct 3180 gtgttgccac ctggattctg cgcgggacgt ccttctgcta cgtcccttcg gccctcaatc 3240 cagcggacct tccttcccgc ggcctgctgc cggctctgcg gcctcttccg cgtcttcgcc 3300 ttcgccctca gacgagtcgg atctcccttt gggccgcctc cccgcgtcga ctttaagacc 3360 aatgacttac aaggcagctg tagatcttag ccacttttta aaagaaaagg ggggactgga 3420 agggctaatt cactcccaac gaagacaaga tctgcttttt gcttgtactg ggtctctctg 3480 gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc 3540 tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg 3600 taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtacgtatag 3660 tagttcatgt catcttatta ttcagtattt ataacttgca aagaaatgaa tatcagagag 3720 tgagaggaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa 3780 tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa 3840 tgtatcttat catgtctggc tctagctatc ccgcccctaa ctccgcccat cccgccccta 3900 actccgccca gttccgccca ttctccgccc catggctgac taattttttt tatttatgca 3960 gaggccgagg ccgcctcggc ctctgagcta ttccagaagt agtgaggagg cttttttgga 4020 ggcctaggga cgtacccaat tcgccctata gtgagtcgta ttacgcgcgc tcactggccg 4080 tcgttttaca acgtcgtgac tgggaaaacc ctggcgttac ccaacttaat cgccttgcag 4140 cacatccccc tttcgccagc tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc 4200 aacagttgcg cagcctgaat ggcgaatggg acgcgccctg tagcggcgca ttaagcgcgg 4260 cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc 4320 ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa 4380 atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac 4440 ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt 4500 tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca 4560 accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt 4620 taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgctta 4680 caatttaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta 4740 aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata 4800 ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc 4860 ggcattttgc cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga 4920 agatcagttg ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct 4980 tgagagtttt cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg 5040 tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta 5100 ttctcagaat gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat 5160 gacagtaaga gaattatgca gtgctgccat aaccatgagt gataacactg cggccaactt 5220 acttctgaca acgatcggag gaccgaagga gctaaccgct tttttgcaca acatggggga 5280 tcatgtaact cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga 5340 gcgtgacacc acgatgcctg tagcaatggc aacaacgttg cgcaaactat taactggcga 5400 actacttact ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc 5460 aggaccactt ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc 5520 cggtgagcgt gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg 5580 tatcgtagtt atctacacga cggggagtca ggcaactatg gatgaacgaa atagacagat 5640 cgctgagata ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata 5700 tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct 5760 ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga 5820 ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg 5880 cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc 5940 aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgttcttct 6000 agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc 6060 tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt 6120 ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg 6180 cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct 6240 atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag 6300 ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag 6360 tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg 6420 gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg 6480 gccttttgct cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac 6540 cgcctttgag tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt 6600 gagcgaggaa gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat 6660 tcattaatgc agctggcacg acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc 6720 aattaatgtg agttagctca ctcattaggc accccaggct ttacacttta tgcttccggc 6780 tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca gctatgacca 6840 tgattacgcc aagcgcgcaa ttaaccctca ctaaagggaa caaaagctgg agctgcaagc 6900 ttaatgtagt cttatgcaat actcttgtag tcttgcaaca tggtaacgat gagttagcaa 6960 catgccttac aaggagagaa aaagcaccgt gcatgccgat tggtggaagt aaggtggtac 7020 gatcgtgcct tattaggaag gcaacagacg ggtctgacat ggattggacg aaccactgaa 7080 ttgccgcatt gcagagatat tgtatttaag tgcctagctc gatacataaa cgggtctctc 7140 tggttagacc agatctgagc ctgggagctc tctggctaac tagggaaccc actgcttaag 7200 cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg cccgtctgtt gtgtgactct 7260 ggtaactaga gatccctcag acccttttag tcagtgtgga aaatctctag cagtggcgcc 7320 cgaacaggga cttgaaagcg aaagggaaac cagaggagct ctctcgacgc aggactcggc 7380 ttgctgaagc gcgcacggca agaggcgagg ggcggcgact ggtgagtacg ccaaaaattt 7440 tgactagcgg aggctagaag gagagagatg ggtgcgagag cgtcagtatt aagcggggga 7500 gaattagatc gcgatgggaa aaaattcggt taaggccagg gggaaagaaa aaatataaat 7560 taaaacatat agtatgggca agcagggagc tagaacgatt cgcagttaat cctggcctgt 7620 tagaaacatc agaaggctgt agacaaatac tgggacagct acaaccatcc cttcagacag 7680 gatcagaaga acttagatca ttatataata cagtagcaac cctctattgt gtgcatcaaa 7740 ggatagagat aaaagacacc aaggaagctt tagacaagat agaggaagag caaaacaaaa 7800 gtaagaccac cgcacagcaa gcggccgctg atcttcagac ctggaggagg agatatgagg 7860 gacaattgga gaagtgaatt atataaatat aaagtagtaa aaattgaacc attaggagta 7920 gcacccacca aggcaaagag aagagtggtg cagagagaaa aaagagcagt gggaatagga 7980 gctttgttcc ttgggttctt gggagcagca ggaagcacta tgggcgcagc gtcaatgacg 8040 ctgacggtac aggccagaca attattgtct ggtatagtgc agcagcagaa caatttgctg 8100 agggctattg aggcgcaaca gcatctgttg caactcacag tctggggcat caagcagctc 8160 caggcaagaa tcctggctgt ggaaagatac ctaaaggatc aacagctcct ggggatttgg 8220 ggttgctctg gaaaactcat ttgcaccact gctgtgcctt ggaatgctag ttggagtaat 8280 aaatctctgg aacagatttg gaatcacacg acctggatgg agtgggacag agaaattaac 8340 aattacacaa gcttaataca ctccttaatt gaagaatcgc aaaaccagca agaaaagaat 8400 gaacaagaat tattggaatt agataaatgg gcaagtttgt ggaattggtt taacataaca 8460 aattggctgt ggtatataaa attattcata atgatagtag gaggcttggt aggtttaaga 8520 atagtttttg ctgtactttc tatagtgaat agagttaggc agggatattc accattatcg 8580 tttcagaccc acctcccaac cccgagggga cccttgcgcc ttttccaagg cagccctggg 8640 tttgcgcagg gacgcggctg ctctgggcgt ggttccggga aacgcagcgg cgccgaccct 8700 gggtctcgca cattcttcac gtccgttcgc agcgtcaccc ggatcttcgc cgctaccctt 8760 gtgggccccc cggcgacgct tcctgctccg cccctaagtc gggaaggttc cttgcggttc 8820 gcggcgtgcc ggacgtgaca aacggaagcc gcacgtctca ctagtaccct cgcagacgga 8880 cagcgccagg gagcaatggc agcgcgccga ccgcgatggg ctgtggccaa tagcggctgc 8940 tcagcagggc gcgccgagag cagcggccgg gaaggggcgg tgcgggaggc ggggtgtggg 9000 gcggtagtgt gggccctgtt cctgcccgcg cggtgttccg cattctgcaa gcctccggag 9060 cgcacgtcgg cagtcggctc cctcgttgac cgaatcaccg acctctctcc ccagggggta 9120 cccagctgtc tagagaattc tagatcttga gacaaatggc agtattcatc cacaatttta 9180 aaagaaaagg ggggattggg gggtacagtg caggggaaag aatagtagac ataatagcaa 9240 cagacataca aactaaagaa ttacaaaaac aaattacaaa aattcaaaat tttcgggttt 9300 attacaggga cagcagagat ccactttggc gccggctcga ggggg 9345 <210> 131 <211> 233 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 131 Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe Leu Ile 1 5 10 15 Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 20 25 30 Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 35 40 45 Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 50 55 60 Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 65 70 75 80 Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala Gln 85 90 95 Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu 100 105 110 Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser 115 120 125 Gln Thr Ser Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr 130 135 140 Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr 145 150 155 160 Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala 165 170 175 Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu 180 185 190 Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val 195 200 205 Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp 210 215 220 Leu Met Arg Val Asp Asn Leu Pro Asn 225 230 <210> 132 <211> 9393 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 132 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcgggttcg gcccattcgg accgcaagga 780 atcggtcaat acactacatg gcgtgatttc atatgcgcga ttgctgatcc ccatgtgtat 840 cactggcaaa ctgtgatgga cgacaccgtc agtgcgtccg tcgcgcaggc tctcgatgag 900 ctgatgcttt gggccgagga ctgccccgaa gtccggcacc tcgtgcacgc ggatttcggc 960 tccaacaatg tcctgacgga caatggccgc ataacagcgg tcattgactg gagcgaggcg 1020 atgttcgggg attcccaata cgaggtcgcc aacatcttct tctggaggcc gtggttggct 1080 tgtatggagc agcagacgcg ctacttcgag cggaggcatc cggagcttgc aggatcgccg 1140 cggctccggg cgtatatgct ccgcattggt cttgaccaac tctatcagag cttggttgac 1200 ggcaatttcg atgatgcagc ttgggcgcag ggtcgatgcg acgcaatcgt ccgatccgga 1260 gccgggactg tcgggcgtac acaaatcgcc cgcagaagcg cggccgtctg gaccgatggc 1320 tgtgtagaag tactcgccga tagtggaaac cgacgcccca gcactcgtcc gagggcaaag 1380 gaatagttaa ttaagaattc gacccagctt tcttgtacaa agtggttggt aagcctatcc 1440 ctaaccctct cctcggtctc gattctacgt agtaatgagc tagcagtctc gaggttaacg 1500 aattccgccc cccccctaac gttactggcc gaagccgctt ggaataaggc cggtgtgcgc 1560 ttgtctatat gttattttcc accatattgc cgtcttttgg caatgtgagg gcccggaaac 1620 ctggccctgt cttcttgacg agcattccta ggggtctttc ccctctcgcc aaaggaatgc 1680 aaggtctgtt gaatgtcgtg aaggaagcag ttcctctgga agcttcttga agacaaacaa 1740 cgtctgtagc gaccctttgc aggcagcgga accccccacc tggcgacagg tgcccctgcg 1800 gccaaaagcc acgtgtataa gatacacctg caaaggcggc acaaccccag tgccacgttg 1860 tgagttggat agttgtggaa agagtcaaat ggctctcctc aagcgtattc aacaaggggc 1920 tgaaggatgc ccagaaggta ccccattgta tgggatctga tctggggcct cggtgcacat 1980 gctttacatg tgtttagtcg aggttaaaaa aacgtctagg ccccccgaac cacggggacg 2040 tggttttcct ttgaaaaaca cgataatacc atggtgagca agggcgagga ggataacatg 2100 gccatcatca aggagttcat gcgcttcaag gtgcacatgg agggctccgt gaacggccac 2160 gagttcgaga tcgagggcga gggcgagggc cgcccctacg agggcaccca gaccgccaag 2220 ctgaaggtga ccaagggtgg ccccctgccc ttcgcctggg acatcctgtc ccctcagttc 2280 atgtacggct ccaaggccta cgtgaagcac cccgccgaca tccccgacta cttgaagctg 2340 tccttccccg agggcttcaa gtgggagcgc gtgatgaact tcgaggacgg cggcgtggtg 2400 accgtgaccc aggactcctc cctgcaggac ggcgagttca tctacaaggt gaagctgcgc 2460 ggcaccaact tcccctccga cggccccgta atgcagaaga agaccatggg ctgggaggcc 2520 tcctccgagc ggatgtaccc cgaggacggc gccctgaagg gcgagatcaa gcagaggctg 2580 aagctgaagg acggcggcca ctacgacgct gaggtcaaga ccacctacaa ggccaagaag 2640 cccgtgcagc tgcccggcgc ctacaacgtc aacatcaagt tggacatcac ctcccacaac 2700 gaggactaca ccatcgtgga acagtacgaa cgcgccgagg gccgccactc caccggcggc 2760 atggacgagc tgtacaagta acaccggtgg cgcgttaagt cgacaatcaa cctctggatt 2820 acaaaatttg tgaaagattg actggtattc ttaactatgt tgctcctttt acgctatgtg 2880 gatacgctgc tttaatgcct ttgtatcatg ctattgcttc ccgtatggct ttcattttct 2940 cctccttgta taaatcctgg ttgctgtctc tttatgagga gttgtggccc gttgtcaggc 3000 aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc cactggttgg ggcattgcca 3060 ccacctgtca gctcctttcc gggactttcg ctttccccct ccctattgcc acggcggaac 3120 tcatcgccgc ctgccttgcc cgctgctgga caggggctcg gctgttgggc actgacaatt 3180 ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct gctcgcctgt gttgccacct 3240 ggattctgcg cgggacgtcc ttctgctacg tcccttcggc cctcaatcca gcggaccttc 3300 cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg tcttcgcctt cgccctcaga 3360 cgagtcggat ctccctttgg gccgcctccc cgcgtcgact ttaagaccaa tgacttacaa 3420 ggcagctgta gatcttagcc actttttaaa agaaaagggg ggactggaag ggctaattca 3480 ctcccaacga agacaagatc tgctttttgc ttgtactggg tctctctggt tagaccagat 3540 ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc aataaagctt 3600 gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta actagagatc 3660 cctcagaccc ttttagtcag tgtggaaaat ctctagcagt acgtatagta gttcatgtca 3720 tcttattatt cagtatttat aacttgcaaa gaaatgaata tcagagagtg agaggaactt 3780 gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa 3840 agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca 3900 tgtctggctc tagctatccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt 3960 tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc 4020 gcctcggcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctagggacg 4080 tacccaattc gccctatagt gagtcgtatt acgcgcgctc actggccgtc gttttacaac 4140 gtcgtgactg ggaaaaccct ggcgttaccc aacttaatcg ccttgcagca catccccctt 4200 tcgccagctg gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa cagttgcgca 4260 gcctgaatgg cgaatgggac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg 4320 ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct 4380 tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc 4440 ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt gattagggtg 4500 atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt 4560 ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg 4620 tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta aaaaatgagc 4680 tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgcttaca atttaggtgg 4740 cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa 4800 tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa 4860 gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct 4920 tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg 4980 tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg 5040 ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt 5100 atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga 5160 cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga 5220 attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac 5280 gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg 5340 ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac 5400 gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct 5460 agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct 5520 gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg 5580 gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat 5640 ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg 5700 tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat 5760 tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct 5820 catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa 5880 gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa 5940 aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc 6000 gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag tgtagccgta 6060 gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct 6120 gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg 6180 atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag 6240 cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc 6300 cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg 6360 agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt 6420 tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg 6480 gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca 6540 catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg 6600 agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc 6660 ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag 6720 ctggcacgac aggtttcccg actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag 6780 ttagctcact cattaggcac cccaggcttt acactttatg cttccggctc gtatgttgtg 6840 tggaattgtg agcggataac aatttcacac aggaaacagc tatgaccatg attacgccaa 6900 gcgcgcaatt aaccctcact aaagggaaca aaagctggag ctgcaagctt aatgtagtct 6960 tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca tgccttacaa 7020 ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga tcgtgcctta 7080 ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt gccgcattgc 7140 agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg gttagaccag 7200 atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc tcaataaagc 7260 ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg taactagaga 7320 tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg aacagggact 7380 tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt gctgaagcgc 7440 gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg actagcggag 7500 gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga attagatcgc 7560 gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta aaacatatag 7620 tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta gaaacatcag 7680 aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga tcagaagaac 7740 ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg atagagataa 7800 aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt aagaccaccg 7860 cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga caattggaga 7920 agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc acccaccaag 7980 gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc tttgttcctt 8040 gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct gacggtacag 8100 gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag ggctattgag 8160 gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca ggcaagaatc 8220 ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg ttgctctgga 8280 aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa atctctggaa 8340 cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa ttacacaagc 8400 ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga acaagaatta 8460 ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa ttggctgtgg 8520 tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat agtttttgct 8580 gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt tcagacccac 8640 ctcccaaccc cgaggggacc cttgcgcctt ttccaaggca gccctgggtt tgcgcaggga 8700 cgcggctgct ctgggcgtgg ttccgggaaa cgcagcggcg ccgaccctgg gtctcgcaca 8760 ttcttcacgt ccgttcgcag cgtcacccgg atcttcgccg ctacccttgt gggccccccg 8820 gcgacgcttc ctgctccgcc cctaagtcgg gaaggttcct tgcggttcgc ggcgtgccgg 8880 acgtgacaaa cggaagccgc acgtctcact agtaccctcg cagacggaca gcgccaggga 8940 gcaatggcag cgcgccgacc gcgatgggct gtggccaata gcggctgctc agcagggcgc 9000 gccgagagca gcggccggga aggggcggtg cgggaggcgg ggtgtggggc ggtagtgtgg 9060 gccctgttcc tgcccgcgcg gtgttccgca ttctgcaagc ctccggagcg cacgtcggca 9120 gtcggctccc tcgttgaccg aatcaccgac ctctctcccc agggggtacc cagctgtcta 9180 gagaattcta gatcttgaga caaatggcag tattcatcca caattttaaa agaaaagggg 9240 ggattggggg gtacagtgca ggggaaagaa tagtagacat aatagcaaca gacatacaaa 9300 ctaaagaatt acaaaaacaa attacaaaaa ttcaaaattt tcgggtttat tacagggaca 9360 gcagagatcc actttggcgc cggctcgagg ggg 9393 <210> 133 <211> 247 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 133 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly 35 40 45 Gln Tyr Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His 50 55 60 Val Tyr His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val 65 70 75 80 Ala Gln Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu 85 90 95 Val Arg His Leu Val His Ala Asp Phe Gly Ser Asn Asn Val Leu Thr 100 105 110 Asp Asn Gly Arg Ile Thr Ala Val Ile Asp Trp Ser Glu Ala Met Phe 115 120 125 Gly Asp Ser Gln Tyr Glu Val Ala Asn Ile Phe Phe Trp Arg Pro Trp 130 135 140 Leu Ala Cys Met Glu Gln Gln Thr Arg Tyr Phe Glu Arg Arg His Pro 145 150 155 160 Glu Leu Ala Gly Ser Pro Arg Leu Arg Ala Tyr Met Leu Arg Ile Gly 165 170 175 Leu Asp Gln Leu Tyr Gln Ser Leu Val Asp Gly Asn Phe Asp Asp Ala 180 185 190 Ala Trp Ala Gln Gly Arg Cys Asp Ala Ile Val Arg Ser Gly Ala Gly 195 200 205 Thr Val Gly Arg Thr Gln Ile Ala Arg Arg Ser Ala Ala Val Trp Thr 210 215 220 Asp Gly Cys Val Glu Val Leu Ala Asp Ser Gly Asn Arg Arg Pro Ser 225 230 235 240 Thr Arg Pro Arg Ala Lys Glu 245 <210> 134 <211> 9465 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 134 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaaaaagcc tgaactcacc 660 gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 720 ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc 780 ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt 840 gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaatttag cgagagcctg 900 acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa 960 ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt 1020 agccagacga gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg 1080 cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac tgtgatggac 1140 gacaccgtca gttgcctttc atacgagacc gagatcctga ctgtcgagta cggattgctt 1200 cctatcggca aaatcgtgga gaagaggatt gaatgtaccg tctattcagt cgataataat 1260 gggaacatct acacacagcc cgtggctcaa tggcacgaca gaggagagca ggaagttttt 1320 gaatactgtc tcgaggacgg atccctcatc cgcgctacta aagatcataa gtttatgacc 1380 gtggacggcc agatgctgcc aattgacgaa atttttgaac gagagctgga tctgatgaga 1440 gtcgacaacc ttccaaactg attaattaag aattcgaccc agctttcttg tacaaagtgg 1500 ttggtaagcc tatccctaac cctctcctcg gtctcgattc tacgtagtaa tgagctagca 1560 gtctcgaggt taacgaattc cgcccccccc ctaacgttac tggccgaagc cgcttggaat 1620 aaggccggtg tgcgcttgtc tatatgttat tttccaccat attgccgtct tttggcaatg 1680 tgagggcccg gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc 1740 tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt 1800 cttgaagaca aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg 1860 acaggtgccc ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac 1920 cccagtgcca cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg 1980 tattcaacaa ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg 2040 ggcctcggtg cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt ctaggccccc 2100 cgaaccacgg ggacgtggtt ttcctttgaa aaacacgata ataccatggc catgagcgag 2160 ctgattaagg agaacatgca catgaagctg tacatggagg gcaccgtgga caaccatcac 2220 ttcaagtgca catccgaggg cgaaggcaag ccctacgagg gcacccagac catgagaatc 2280 aaggtggtcg agggcggccc tctccccttc gccttcgaca tcctggctac tagcttcctc 2340 tacggcagca agaccttcat caaccacacc cagggcatcc ccgacttctt caagcagtcc 2400 ttccctgagg gcttcacatg ggagagagtc accacatacg aagacggggg cgtgctgacc 2460 gctacccagg acaccagcct ccaggacggc tgcctcatct acaacgtcaa gatcagaggg 2520 gtgaacttca catccaacgg ccctgtgatg cagaagaaaa cactcggctg ggaggccttc 2580 accgagacgc tgtaccccgc tgacggcggc ctggaaggca gaaacgacat ggccctgaag 2640 ctcgtgggcg ggagccatct gatcgcaaac atcaagacca catatagatc caagaaaccc 2700 gctaagaacc tcaagatgcc tggcgtctac tatgtggact acagactgga aagaatcaag 2760 gaggccaaca acgagaccta cgtcgagcag cacgaggtgg cagtggccag atactgcgac 2820 ctccctagca aactggggca caagcttaat taacaccggt ggcgcgttaa gtcgacaatc 2880 aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat gttgctcctt 2940 ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct tcccgtatgg 3000 ctttcatttt ctcctccttg tataaatcct ggttgctgtc tctttatgag gagttgtggc 3060 ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc cccactggtt 3120 ggggcattgc caccacctgt cagctccttt ccgggacttt cgctttcccc ctccctattg 3180 ccacggcgga actcatcgcc gcctgccttg cccgctgctg gacaggggct cggctgttgg 3240 gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc ctttccttgg ctgctcgcct 3300 gtgttgccac ctggattctg cgcgggacgt ccttctgcta cgtcccttcg gccctcaatc 3360 cagcggacct tccttcccgc ggcctgctgc cggctctgcg gcctcttccg cgtcttcgcc 3420 ttcgccctca gacgagtcgg atctcccttt gggccgcctc cccgcgtcga ctttaagacc 3480 aatgacttac aaggcagctg tagatcttag ccacttttta aaagaaaagg ggggactgga 3540 agggctaatt cactcccaac gaagacaaga tctgcttttt gcttgtactg ggtctctctg 3600 gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc 3660 tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg 3720 taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtacgtatag 3780 tagttcatgt catcttatta ttcagtattt ataacttgca aagaaatgaa tatcagagag 3840 tgagaggaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa 3900 tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa 3960 tgtatcttat catgtctggc tctagctatc ccgcccctaa ctccgcccat cccgccccta 4020 actccgccca gttccgccca ttctccgccc catggctgac taattttttt tatttatgca 4080 gaggccgagg ccgcctcggc ctctgagcta ttccagaagt agtgaggagg cttttttgga 4140 ggcctaggga cgtacccaat tcgccctata gtgagtcgta ttacgcgcgc tcactggccg 4200 tcgttttaca acgtcgtgac tgggaaaacc ctggcgttac ccaacttaat cgccttgcag 4260 cacatccccc tttcgccagc tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc 4320 aacagttgcg cagcctgaat ggcgaatggg acgcgccctg tagcggcgca ttaagcgcgg 4380 cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc 4440 ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa 4500 atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac 4560 ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt 4620 tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca 4680 accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt 4740 taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgctta 4800 caatttaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta 4860 aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata 4920 ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc 4980 ggcattttgc cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga 5040 agatcagttg ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct 5100 tgagagtttt cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg 5160 tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta 5220 ttctcagaat gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat 5280 gacagtaaga gaattatgca gtgctgccat aaccatgagt gataacactg cggccaactt 5340 acttctgaca acgatcggag gaccgaagga gctaaccgct tttttgcaca acatggggga 5400 tcatgtaact cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga 5460 gcgtgacacc acgatgcctg tagcaatggc aacaacgttg cgcaaactat taactggcga 5520 actacttact ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc 5580 aggaccactt ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc 5640 cggtgagcgt gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg 5700 tatcgtagtt atctacacga cggggagtca ggcaactatg gatgaacgaa atagacagat 5760 cgctgagata ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata 5820 tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct 5880 ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga 5940 ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg 6000 cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc 6060 aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgttcttct 6120 agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc 6180 tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt 6240 ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg 6300 cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct 6360 atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag 6420 ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag 6480 tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg 6540 gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg 6600 gccttttgct cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac 6660 cgcctttgag tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt 6720 gagcgaggaa gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat 6780 tcattaatgc agctggcacg acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc 6840 aattaatgtg agttagctca ctcattaggc accccaggct ttacacttta tgcttccggc 6900 tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca gctatgacca 6960 tgattacgcc aagcgcgcaa ttaaccctca ctaaagggaa caaaagctgg agctgcaagc 7020 ttaatgtagt cttatgcaat actcttgtag tcttgcaaca tggtaacgat gagttagcaa 7080 catgccttac aaggagagaa aaagcaccgt gcatgccgat tggtggaagt aaggtggtac 7140 gatcgtgcct tattaggaag gcaacagacg ggtctgacat ggattggacg aaccactgaa 7200 ttgccgcatt gcagagatat tgtatttaag tgcctagctc gatacataaa cgggtctctc 7260 tggttagacc agatctgagc ctgggagctc tctggctaac tagggaaccc actgcttaag 7320 cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg cccgtctgtt gtgtgactct 7380 ggtaactaga gatccctcag acccttttag tcagtgtgga aaatctctag cagtggcgcc 7440 cgaacaggga cttgaaagcg aaagggaaac cagaggagct ctctcgacgc aggactcggc 7500 ttgctgaagc gcgcacggca agaggcgagg ggcggcgact ggtgagtacg ccaaaaattt 7560 tgactagcgg aggctagaag gagagagatg ggtgcgagag cgtcagtatt aagcggggga 7620 gaattagatc gcgatgggaa aaaattcggt taaggccagg gggaaagaaa aaatataaat 7680 taaaacatat agtatgggca agcagggagc tagaacgatt cgcagttaat cctggcctgt 7740 tagaaacatc agaaggctgt agacaaatac tgggacagct acaaccatcc cttcagacag 7800 gatcagaaga acttagatca ttatataata cagtagcaac cctctattgt gtgcatcaaa 7860 ggatagagat aaaagacacc aaggaagctt tagacaagat agaggaagag caaaacaaaa 7920 gtaagaccac cgcacagcaa gcggccgctg atcttcagac ctggaggagg agatatgagg 7980 gacaattgga gaagtgaatt atataaatat aaagtagtaa aaattgaacc attaggagta 8040 gcacccacca aggcaaagag aagagtggtg cagagagaaa aaagagcagt gggaatagga 8100 gctttgttcc ttgggttctt gggagcagca ggaagcacta tgggcgcagc gtcaatgacg 8160 ctgacggtac aggccagaca attattgtct ggtatagtgc agcagcagaa caatttgctg 8220 agggctattg aggcgcaaca gcatctgttg caactcacag tctggggcat caagcagctc 8280 caggcaagaa tcctggctgt ggaaagatac ctaaaggatc aacagctcct ggggatttgg 8340 ggttgctctg gaaaactcat ttgcaccact gctgtgcctt ggaatgctag ttggagtaat 8400 aaatctctgg aacagatttg gaatcacacg acctggatgg agtgggacag agaaattaac 8460 aattacacaa gcttaataca ctccttaatt gaagaatcgc aaaaccagca agaaaagaat 8520 gaacaagaat tattggaatt agataaatgg gcaagtttgt ggaattggtt taacataaca 8580 aattggctgt ggtatataaa attattcata atgatagtag gaggcttggt aggtttaaga 8640 atagtttttg ctgtactttc tatagtgaat agagttaggc agggatattc accattatcg 8700 tttcagaccc acctcccaac cccgagggga cccttgcgcc ttttccaagg cagccctggg 8760 tttgcgcagg gacgcggctg ctctgggcgt ggttccggga aacgcagcgg cgccgaccct 8820 gggtctcgca cattcttcac gtccgttcgc agcgtcaccc ggatcttcgc cgctaccctt 8880 gtgggccccc cggcgacgct tcctgctccg cccctaagtc gggaaggttc cttgcggttc 8940 gcggcgtgcc ggacgtgaca aacggaagcc gcacgtctca ctagtaccct cgcagacgga 9000 cagcgccagg gagcaatggc agcgcgccga ccgcgatggg ctgtggccaa tagcggctgc 9060 tcagcagggc gcgccgagag cagcggccgg gaaggggcgg tgcgggaggc ggggtgtggg 9120 gcggtagtgt gggccctgtt cctgcccgcg cggtgttccg cattctgcaa gcctccggag 9180 cgcacgtcgg cagtcggctc cctcgttgac cgaatcaccg acctctctcc ccagggggta 9240 cccagctgtc tagagaattc tagatcttga gacaaatggc agtattcatc cacaatttta 9300 aaagaaaagg ggggattggg gggtacagtg caggggaaag aatagtagac ataatagcaa 9360 cagacataca aactaaagaa ttacaaaaac aaattacaaa aattcaaaat tttcgggttt 9420 attacaggga cagcagagat ccactttggc gccggctcga ggggg 9465 <210> 135 <211> 273 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 135 Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe Leu Ile 1 5 10 15 Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 20 25 30 Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 35 40 45 Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 50 55 60 Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 65 70 75 80 Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala Gln 85 90 95 Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu 100 105 110 Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser 115 120 125 Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr 130 135 140 Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr 145 150 155 160 His Trp Gln Thr Val Met Asp Asp Thr Val Ser Cys Leu Ser Tyr Glu 165 170 175 Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile 180 185 190 Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly 195 200 205 Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln 210 215 220 Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr 225 230 235 240 Lys Asp His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp 245 250 255 Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro 260 265 270 Asn <210> 136 <211> 9273 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 136 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcgcgtccg tcgcgcaggc tctcgatgag 780 ctgatgcttt gggccgagga ctgccccgaa gtccggcacc tcgtgcacgc ggatttcggc 840 tccaacaatg tcctgacgga caatggccgc ataacagcgg tcattgactg gagcgaggcg 900 atgttcgggg attcccaata cgaggtcgcc aacatcttct tctggaggcc gtggttggct 960 tgtatggagc agcagacgcg ctacttcgag cggaggcatc cggagcttgc aggatcgccg 1020 cggctccggg cgtatatgct ccgcattggt cttgaccaac tctatcagag cttggttgac 1080 ggcaatttcg atgatgcagc ttgggcgcag ggtcgatgcg acgcaatcgt ccgatccgga 1140 gccgggactg tcgggcgtac acaaatcgcc cgcagaagcg cggccgtctg gaccgatggc 1200 tgtgtagaag tactcgccga tagtggaaac cgacgcccca gcactcgtcc gagggcaaag 1260 gaatagttaa ttaagaattc gacccagctt tcttgtacaa agtggttggt aagcctatcc 1320 ctaaccctct cctcggtctc gattctacgt agtaatgagc tagcagtctc gaggttaacg 1380 aattccgccc cccccctaac gttactggcc gaagccgctt ggaataaggc cggtgtgcgc 1440 ttgtctatat gttattttcc accatattgc cgtcttttgg caatgtgagg gcccggaaac 1500 ctggccctgt cttcttgacg agcattccta ggggtctttc ccctctcgcc aaaggaatgc 1560 aaggtctgtt gaatgtcgtg aaggaagcag ttcctctgga agcttcttga agacaaacaa 1620 cgtctgtagc gaccctttgc aggcagcgga accccccacc tggcgacagg tgcccctgcg 1680 gccaaaagcc acgtgtataa gatacacctg caaaggcggc acaaccccag tgccacgttg 1740 tgagttggat agttgtggaa agagtcaaat ggctctcctc aagcgtattc aacaaggggc 1800 tgaaggatgc ccagaaggta ccccattgta tgggatctga tctggggcct cggtgcacat 1860 gctttacatg tgtttagtcg aggttaaaaa aacgtctagg ccccccgaac cacggggacg 1920 tggttttcct ttgaaaaaca cgataatacc atggtgagca agggcgagga ggataacatg 1980 gccatcatca aggagttcat gcgcttcaag gtgcacatgg agggctccgt gaacggccac 2040 gagttcgaga tcgagggcga gggcgagggc cgcccctacg agggcaccca gaccgccaag 2100 ctgaaggtga ccaagggtgg ccccctgccc ttcgcctggg acatcctgtc ccctcagttc 2160 atgtacggct ccaaggccta cgtgaagcac cccgccgaca tccccgacta cttgaagctg 2220 tccttccccg agggcttcaa gtgggagcgc gtgatgaact tcgaggacgg cggcgtggtg 2280 accgtgaccc aggactcctc cctgcaggac ggcgagttca tctacaaggt gaagctgcgc 2340 ggcaccaact tcccctccga cggccccgta atgcagaaga agaccatggg ctgggaggcc 2400 tcctccgagc ggatgtaccc cgaggacggc gccctgaagg gcgagatcaa gcagaggctg 2460 aagctgaagg acggcggcca ctacgacgct gaggtcaaga ccacctacaa ggccaagaag 2520 cccgtgcagc tgcccggcgc ctacaacgtc aacatcaagt tggacatcac ctcccacaac 2580 gaggactaca ccatcgtgga acagtacgaa cgcgccgagg gccgccactc caccggcggc 2640 atggacgagc tgtacaagta acaccggtgg cgcgttaagt cgacaatcaa cctctggatt 2700 acaaaatttg tgaaagattg actggtattc ttaactatgt tgctcctttt acgctatgtg 2760 gatacgctgc tttaatgcct ttgtatcatg ctattgcttc ccgtatggct ttcattttct 2820 cctccttgta taaatcctgg ttgctgtctc tttatgagga gttgtggccc gttgtcaggc 2880 aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc cactggttgg ggcattgcca 2940 ccacctgtca gctcctttcc gggactttcg ctttccccct ccctattgcc acggcggaac 3000 tcatcgccgc ctgccttgcc cgctgctgga caggggctcg gctgttgggc actgacaatt 3060 ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct gctcgcctgt gttgccacct 3120 ggattctgcg cgggacgtcc ttctgctacg tcccttcggc cctcaatcca gcggaccttc 3180 cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg tcttcgcctt cgccctcaga 3240 cgagtcggat ctccctttgg gccgcctccc cgcgtcgact ttaagaccaa tgacttacaa 3300 ggcagctgta gatcttagcc actttttaaa agaaaagggg ggactggaag ggctaattca 3360 ctcccaacga agacaagatc tgctttttgc ttgtactggg tctctctggt tagaccagat 3420 ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc aataaagctt 3480 gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta actagagatc 3540 cctcagaccc ttttagtcag tgtggaaaat ctctagcagt acgtatagta gttcatgtca 3600 tcttattatt cagtatttat aacttgcaaa gaaatgaata tcagagagtg agaggaactt 3660 gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa 3720 agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca 3780 tgtctggctc tagctatccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt 3840 tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc 3900 gcctcggcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctagggacg 3960 tacccaattc gccctatagt gagtcgtatt acgcgcgctc actggccgtc gttttacaac 4020 gtcgtgactg ggaaaaccct ggcgttaccc aacttaatcg ccttgcagca catccccctt 4080 tcgccagctg gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa cagttgcgca 4140 gcctgaatgg cgaatgggac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg 4200 ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct 4260 tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc 4320 ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt gattagggtg 4380 atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt 4440 ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg 4500 tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta aaaaatgagc 4560 tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgcttaca atttaggtgg 4620 cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa 4680 tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa 4740 gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct 4800 tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg 4860 tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg 4920 ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt 4980 atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga 5040 cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga 5100 attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac 5160 gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg 5220 ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac 5280 gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct 5340 agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct 5400 gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg 5460 gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat 5520 ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg 5580 tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat 5640 tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct 5700 catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa 5760 gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa 5820 aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc 5880 gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag tgtagccgta 5940 gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct 6000 gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg 6060 atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag 6120 cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc 6180 cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg 6240 agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt 6300 tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg 6360 gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca 6420 catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg 6480 agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc 6540 ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag 6600 ctggcacgac aggtttcccg actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag 6660 ttagctcact cattaggcac cccaggcttt acactttatg cttccggctc gtatgttgtg 6720 tggaattgtg agcggataac aatttcacac aggaaacagc tatgaccatg attacgccaa 6780 gcgcgcaatt aaccctcact aaagggaaca aaagctggag ctgcaagctt aatgtagtct 6840 tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca tgccttacaa 6900 ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga tcgtgcctta 6960 ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt gccgcattgc 7020 agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg gttagaccag 7080 atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc tcaataaagc 7140 ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg taactagaga 7200 tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg aacagggact 7260 tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt gctgaagcgc 7320 gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg actagcggag 7380 gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga attagatcgc 7440 gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta aaacatatag 7500 tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta gaaacatcag 7560 aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga tcagaagaac 7620 ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg atagagataa 7680 aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt aagaccaccg 7740 cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga caattggaga 7800 agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc acccaccaag 7860 gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc tttgttcctt 7920 gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct gacggtacag 7980 gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag ggctattgag 8040 gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca ggcaagaatc 8100 ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg ttgctctgga 8160 aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa atctctggaa 8220 cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa ttacacaagc 8280 ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga acaagaatta 8340 ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa ttggctgtgg 8400 tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat agtttttgct 8460 gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt tcagacccac 8520 ctcccaaccc cgaggggacc cttgcgcctt ttccaaggca gccctgggtt tgcgcaggga 8580 cgcggctgct ctgggcgtgg ttccgggaaa cgcagcggcg ccgaccctgg gtctcgcaca 8640 ttcttcacgt ccgttcgcag cgtcacccgg atcttcgccg ctacccttgt gggccccccg 8700 gcgacgcttc ctgctccgcc cctaagtcgg gaaggttcct tgcggttcgc ggcgtgccgg 8760 acgtgacaaa cggaagccgc acgtctcact agtaccctcg cagacggaca gcgccaggga 8820 gcaatggcag cgcgccgacc gcgatgggct gtggccaata gcggctgctc agcagggcgc 8880 gccgagagca gcggccggga aggggcggtg cgggaggcgg ggtgtggggc ggtagtgtgg 8940 gccctgttcc tgcccgcgcg gtgttccgca ttctgcaagc ctccggagcg cacgtcggca 9000 gtcggctccc tcgttgaccg aatcaccgac ctctctcccc agggggtacc cagctgtcta 9060 gagaattcta gatcttgaga caaatggcag tattcatcca caattttaaa agaaaagggg 9120 ggattggggg gtacagtgca ggggaaagaa tagtagacat aatagcaaca gacatacaaa 9180 ctaaagaatt acaaaaacaa attacaaaaa ttcaaaattt tcgggtttat tacagggaca 9240 gcagagatcc actttggcgc cggctcgagg ggg 9273 <210> 137 <211> 207 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 137 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Ala Ser Val Ala Gln Ala Leu Asp Glu Leu Met 35 40 45 Leu Trp Ala Glu Asp Cys Pro Glu Val Arg His Leu Val His Ala Asp 50 55 60 Phe Gly Ser Asn Asn Val Leu Thr Asp Asn Gly Arg Ile Thr Ala Val 65 70 75 80 Ile Asp Trp Ser Glu Ala Met Phe Gly Asp Ser Gln Tyr Glu Val Ala 85 90 95 Asn Ile Phe Phe Trp Arg Pro Trp Leu Ala Cys Met Glu Gln Gln Thr 100 105 110 Arg Tyr Phe Glu Arg Arg His Pro Glu Leu Ala Gly Ser Pro Arg Leu 115 120 125 Arg Ala Tyr Met Leu Arg Ile Gly Leu Asp Gln Leu Tyr Gln Ser Leu 130 135 140 Val Asp Gly Asn Phe Asp Asp Ala Ala Trp Ala Gln Gly Arg Cys Asp 145 150 155 160 Ala Ile Val Arg Ser Gly Ala Gly Thr Val Gly Arg Thr Gln Ile Ala 165 170 175 Arg Arg Ser Ala Ala Val Trp Thr Asp Gly Cys Val Glu Val Leu Ala 180 185 190 Asp Ser Gly Asn Arg Arg Pro Ser Thr Arg Pro Arg Ala Lys Glu 195 200 205 <210> 138 <211> 9606 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 138 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaaaaagcc tgaactcacc 660 gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 720 ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc 780 ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt 840 gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaatttag cgagagcctg 900 acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa 960 ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt 1020 agccagacga gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg 1080 cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac tgtgatggac 1140 gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc tgatgctttg ggccgaggac 1200 tgccccgaag tccggcacct cgtgcacgcg gatttcggct ccaacaatgt cctgacggac 1260 aatggccgca taacagcggt cattgactgg agctgccttt catacgagac cgagatcctg 1320 actgtcgagt acggattgct tcctatcggc aaaatcgtgg agaagaggat tgaatgtacc 1380 gtctattcag tcgataataa tgggaacatc tacacacagc ccgtggctca atggcacgac 1440 agaggagagc aggaagtttt tgaatactgt ctcgaggacg gatccctcat ccgcgctact 1500 aaagatcata agtttatgac cgtggacggc cagatgctgc caattgacga aatttttgaa 1560 cgagagctgg atctgatgag agtcgacaac cttccaaact gattaattaa gaattcgacc 1620 cagctttctt gtacaaagtg gttggtaagc ctatccctaa ccctctcctc ggtctcgatt 1680 ctacgtagta atgagctagc agtctcgagg ttaacgaatt ccgccccccc cctaacgtta 1740 ctggccgaag ccgcttggaa taaggccggt gtgcgcttgt ctatatgtta ttttccacca 1800 tattgccgtc ttttggcaat gtgagggccc ggaaacctgg ccctgtcttc ttgacgagca 1860 ttcctagggg tctttcccct ctcgccaaag gaatgcaagg tctgttgaat gtcgtgaagg 1920 aagcagttcc tctggaagct tcttgaagac aaacaacgtc tgtagcgacc ctttgcaggc 1980 agcggaaccc cccacctggc gacaggtgcc cctgcggcca aaagccacgt gtataagata 2040 cacctgcaaa ggcggcacaa ccccagtgcc acgttgtgag ttggatagtt gtggaaagag 2100 tcaaatggct ctcctcaagc gtattcaaca aggggctgaa ggatgcccag aaggtacccc 2160 attgtatggg atctgatctg gggcctcggt gcacatgctt tacatgtgtt tagtcgaggt 2220 taaaaaaacg tctaggcccc ccgaaccacg gggacgtggt tttcctttga aaaacacgat 2280 aataccatgg ccatgagcga gctgattaag gagaacatgc acatgaagct gtacatggag 2340 ggcaccgtgg acaaccatca cttcaagtgc acatccgagg gcgaaggcaa gccctacgag 2400 ggcacccaga ccatgagaat caaggtggtc gagggcggcc ctctcccctt cgccttcgac 2460 atcctggcta ctagcttcct ctacggcagc aagaccttca tcaaccacac ccagggcatc 2520 cccgacttct tcaagcagtc cttccctgag ggcttcacat gggagagagt caccacatac 2580 gaagacgggg gcgtgctgac cgctacccag gacaccagcc tccaggacgg ctgcctcatc 2640 tacaacgtca agatcagagg ggtgaacttc acatccaacg gccctgtgat gcagaagaaa 2700 acactcggct gggaggcctt caccgagacg ctgtaccccg ctgacggcgg cctggaaggc 2760 agaaacgaca tggccctgaa gctcgtgggc gggagccatc tgatcgcaaa catcaagacc 2820 acatatagat ccaagaaacc cgctaagaac ctcaagatgc ctggcgtcta ctatgtggac 2880 tacagactgg aaagaatcaa ggaggccaac aacgagacct acgtcgagca gcacgaggtg 2940 gcagtggcca gatactgcga cctccctagc aaactggggc acaagcttaa ttaacaccgg 3000 tggcgcgtta agtcgacaat caacctctgg attacaaaat ttgtgaaaga ttgactggta 3060 ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc 3120 atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt 3180 ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg 3240 ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt 3300 tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct 3360 ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt 3420 cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct 3480 acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc 3540 ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct 3600 ccccgcgtcg actttaagac caatgactta caaggcagct gtagatctta gccacttttt 3660 aaaagaaaag gggggactgg aagggctaat tcactcccaa cgaagacaag atctgctttt 3720 tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact 3780 agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc 3840 ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa 3900 aatctctagc agtacgtata gtagttcatg tcatcttatt attcagtatt tataacttgc 3960 aaagaaatga atatcagaga gtgagaggaa cttgtttatt gcagcttata atggttacaa 4020 ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg 4080 tggtttgtcc aaactcatca atgtatctta tcatgtctgg ctctagctat cccgccccta 4140 actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga 4200 ctaatttttt ttatttatgc agaggccgag gccgcctcgg cctctgagct attccagaag 4260 tagtgaggag gcttttttgg aggcctaggg acgtacccaa ttcgccctat agtgagtcgt 4320 attacgcgcg ctcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta 4380 cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg 4440 cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg gacgcgccct 4500 gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg 4560 ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg 4620 gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac 4680 ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct 4740 gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt 4800 tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta taagggattt 4860 tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt 4920 ttaacaaaat attaacgctt acaatttagg tggcactttt cggggaaatg tgcgcggaac 4980 ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc 5040 ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt 5100 cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct 5160 ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga 5220 tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag 5280 cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca 5340 actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga 5400 aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag 5460 tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc 5520 ttttttgcac aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa 5580 tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt 5640 gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg 5700 gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt 5760 tattgctgat aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg 5820 gccagatggt aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat 5880 ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact 5940 gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa 6000 aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt 6060 ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt 6120 ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg 6180 tttgccggat caagagctac caactctttt tccgaaggta actggcttca gcagagcgca 6240 gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca agaactctgt 6300 agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga 6360 taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc 6420 gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact 6480 gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga 6540 caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg 6600 aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt 6660 tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt 6720 acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga 6780 ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac 6840 gaccgagcgc agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc 6900 tctccccgcg cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa 6960 agcgggcagt gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc 7020 tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca 7080 cacaggaaac agctatgacc atgattacgc caagcgcgca attaaccctc actaaaggga 7140 acaaaagctg gagctgcaag cttaatgtag tcttatgcaa tactcttgta gtcttgcaac 7200 atggtaacga tgagttagca acatgcctta caaggagaga aaaagcaccg tgcatgccga 7260 ttggtggaag taaggtggta cgatcgtgcc ttattaggaa ggcaacagac gggtctgaca 7320 tggattggac gaaccactga attgccgcat tgcagagata ttgtatttaa gtgcctagct 7380 cgatacataa acgggtctct ctggttagac cagatctgag cctgggagct ctctggctaa 7440 ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca agtagtgtgt 7500 gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta gtcagtgtgg 7560 aaaatctcta gcagtggcgc ccgaacaggg acttgaaagc gaaagggaaa ccagaggagc 7620 tctctcgacg caggactcgg cttgctgaag cgcgcacggc aagaggcgag gggcggcgac 7680 tggtgagtac gccaaaaatt ttgactagcg gaggctagaa ggagagagat gggtgcgaga 7740 gcgtcagtat taagcggggg agaattagat cgcgatggga aaaaattcgg ttaaggccag 7800 ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag ctagaacgat 7860 tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata ctgggacagc 7920 tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat acagtagcaa 7980 ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct ttagacaaga 8040 tagaggaaga gcaaaacaaa agtaagacca ccgcacagca agcggccgct gatcttcaga 8100 cctggaggag gagatatgag ggacaattgg agaagtgaat tatataaata taaagtagta 8160 aaaattgaac cattaggagt agcacccacc aaggcaaaga gaagagtggt gcagagagaa 8220 aaaagagcag tgggaatagg agctttgttc cttgggttct tgggagcagc aggaagcact 8280 atgggcgcag cgtcaatgac gctgacggta caggccagac aattattgtc tggtatagtg 8340 cagcagcaga acaatttgct gagggctatt gaggcgcaac agcatctgtt gcaactcaca 8400 gtctggggca tcaagcagct ccaggcaaga atcctggctg tggaaagata cctaaaggat 8460 caacagctcc tggggatttg gggttgctct ggaaaactca tttgcaccac tgctgtgcct 8520 tggaatgcta gttggagtaa taaatctctg gaacagattt ggaatcacac gacctggatg 8580 gagtgggaca gagaaattaa caattacaca agcttaatac actccttaat tgaagaatcg 8640 caaaaccagc aagaaaagaa tgaacaagaa ttattggaat tagataaatg ggcaagtttg 8700 tggaattggt ttaacataac aaattggctg tggtatataa aattattcat aatgatagta 8760 ggaggcttgg taggtttaag aatagttttt gctgtacttt ctatagtgaa tagagttagg 8820 cagggatatt caccattatc gtttcagacc cacctcccaa ccccgagggg acccttgcgc 8880 cttttccaag gcagccctgg gtttgcgcag ggacgcggct gctctgggcg tggttccggg 8940 aaacgcagcg gcgccgaccc tgggtctcgc acattcttca cgtccgttcg cagcgtcacc 9000 cggatcttcg ccgctaccct tgtgggcccc ccggcgacgc ttcctgctcc gcccctaagt 9060 cgggaaggtt ccttgcggtt cgcggcgtgc cggacgtgac aaacggaagc cgcacgtctc 9120 actagtaccc tcgcagacgg acagcgccag ggagcaatgg cagcgcgccg accgcgatgg 9180 gctgtggcca atagcggctg ctcagcaggg cgcgccgaga gcagcggccg ggaaggggcg 9240 gtgcgggagg cggggtgtgg ggcggtagtg tgggccctgt tcctgcccgc gcggtgttcc 9300 gcattctgca agcctccgga gcgcacgtcg gcagtcggct ccctcgttga ccgaatcacc 9360 gacctctctc cccagggggt acccagctgt ctagagaatt ctagatcttg agacaaatgg 9420 cagtattcat ccacaatttt aaaagaaaag gggggattgg ggggtacagt gcaggggaaa 9480 gaatagtaga cataatagca acagacatac aaactaaaga attacaaaaa caaattacaa 9540 aaattcaaaa ttttcgggtt tattacaggg acagcagaga tccactttgg cgccggctcg 9600 aggggg 9606 <210> 139 <211> 320 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 139 Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe Leu Ile 1 5 10 15 Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 20 25 30 Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 35 40 45 Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 50 55 60 Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 65 70 75 80 Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala Gln 85 90 95 Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu 100 105 110 Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser 115 120 125 Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr 130 135 140 Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr 145 150 155 160 His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln 165 170 175 Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg 180 185 190 His Leu Val His Ala Asp Phe Gly Ser Asn Asn Val Leu Thr Asp Asn 195 200 205 Gly Arg Ile Thr Ala Val Ile Asp Trp Ser Cys Leu Ser Tyr Glu Thr 210 215 220 Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val 225 230 235 240 Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn 245 250 255 Ile Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu 260 265 270 Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys 275 280 285 Asp His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu 290 295 300 Ile Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn 305 310 315 320 <210> 140 <211> 9132 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 140 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcgaggcga tgttcgggga ttcccaatac 780 gaggtcgcca acatcttctt ctggaggccg tggttggctt gtatggagca gcagacgcgc 840 tacttcgagc ggaggcatcc ggagcttgca ggatcgccgc ggctccgggc gtatatgctc 900 cgcattggtc ttgaccaact ctatcagagc ttggttgacg gcaatttcga tgatgcagct 960 tgggcgcagg gtcgatgcga cgcaatcgtc cgatccggag ccgggactgt cgggcgtaca 1020 caaatcgccc gcagaagcgc ggccgtctgg accgatggct gtgtagaagt actcgccgat 1080 agtggaaacc gacgccccag cactcgtccg agggcaaagg aatagttaat taagaattcg 1140 acccagcttt cttgtacaaa gtggttggta agcctatccc taaccctctc ctcggtctcg 1200 attctacgta gtaatgagct agcagtctcg aggttaacga attccgcccc ccccctaacg 1260 ttactggccg aagccgcttg gaataaggcc ggtgtgcgct tgtctatatg ttattttcca 1320 ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga 1380 gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga 1440 aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca 1500 ggcagcggaa ccccccacct ggcgacaggt gcccctgcgg ccaaaagcca cgtgtataag 1560 atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa 1620 gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac 1680 cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga 1740 ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac 1800 gataatacca tggtgagcaa gggcgaggag gataacatgg ccatcatcaa ggagttcatg 1860 cgcttcaagg tgcacatgga gggctccgtg aacggccacg agttcgagat cgagggcgag 1920 ggcgagggcc gcccctacga gggcacccag accgccaagc tgaaggtgac caagggtggc 1980 cccctgccct tcgcctggga catcctgtcc cctcagttca tgtacggctc caaggcctac 2040 gtgaagcacc ccgccgacat ccccgactac ttgaagctgt ccttccccga gggcttcaag 2100 tgggagcgcg tgatgaactt cgaggacggc ggcgtggtga ccgtgaccca ggactcctcc 2160 ctgcaggacg gcgagttcat ctacaaggtg aagctgcgcg gcaccaactt cccctccgac 2220 ggccccgtaa tgcagaagaa gaccatgggc tgggaggcct cctccgagcg gatgtacccc 2280 gaggacggcg ccctgaaggg cgagatcaag cagaggctga agctgaagga cggcggccac 2340 tacgacgctg aggtcaagac cacctacaag gccaagaagc ccgtgcagct gcccggcgcc 2400 tacaacgtca acatcaagtt ggacatcacc tcccacaacg aggactacac catcgtggaa 2460 cagtacgaac gcgccgaggg ccgccactcc accggcggca tggacgagct gtacaagtaa 2520 caccggtggc gcgttaagtc gacaatcaac ctctggatta caaaatttgt gaaagattga 2580 ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt 2640 tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt 2700 tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg 2760 tgtttgctga cgcaaccccc actggttggg gcattgccac cacctgtcag ctcctttccg 2820 ggactttcgc tttccccctc cctattgcca cggcggaact catcgccgcc tgccttgccc 2880 gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgttg tcggggaaat 2940 catcgtcctt tccttggctg ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct 3000 tctgctacgt cccttcggcc ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg 3060 ctctgcggcc tcttccgcgt cttcgccttc gccctcagac gagtcggatc tccctttggg 3120 ccgcctcccc gcgtcgactt taagaccaat gacttacaag gcagctgtag atcttagcca 3180 ctttttaaaa gaaaaggggg gactggaagg gctaattcac tcccaacgaa gacaagatct 3240 gctttttgct tgtactgggt ctctctggtt agaccagatc tgagcctggg agctctctgg 3300 ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt 3360 gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct tttagtcagt 3420 gtggaaaatc tctagcagta cgtatagtag ttcatgtcat cttattattc agtatttata 3480 acttgcaaag aaatgaatat cagagagtga gaggaacttg tttattgcag cttataatgg 3540 ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc 3600 tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggctct agctatcccg 3660 cccctaactc cgcccatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat 3720 ggctgactaa ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc 3780 cagaagtagt gaggaggctt ttttggaggc ctagggacgt acccaattcg ccctatagtg 3840 agtcgtatta cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg 3900 gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg 3960 aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg 4020 cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta 4080 cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt 4140 tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg 4200 ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat 4260 cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac 4320 tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag 4380 ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg 4440 cgaattttaa caaaatatta acgcttacaa tttaggtggc acttttcggg gaaatgtgcg 4500 cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca 4560 ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt 4620 ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga 4680 aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga 4740 actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat 4800 gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca 4860 agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt 4920 cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac 4980 catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct 5040 aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga 5100 gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac 5160 aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat 5220 agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg 5280 ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc 5340 actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc 5400 aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg 5460 gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta 5520 atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg 5580 tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga 5640 tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt 5700 ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag 5760 agcgcagata ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa 5820 ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag 5880 tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca 5940 gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac 6000 cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa 6060 ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc 6120 agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg 6180 tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc 6240 ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc 6300 ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag 6360 ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa 6420 accgcctctc cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca ggtttcccga 6480 ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt tagctcactc attaggcacc 6540 ccaggcttta cactttatgc ttccggctcg tatgttgtgt ggaattgtga gcggataaca 6600 atttcacaca ggaaacagct atgaccatga ttacgccaag cgcgcaatta accctcacta 6660 aagggaacaa aagctggagc tgcaagctta atgtagtctt atgcaatact cttgtagtct 6720 tgcaacatgg taacgatgag ttagcaacat gccttacaag gagagaaaaa gcaccgtgca 6780 tgccgattgg tggaagtaag gtggtacgat cgtgccttat taggaaggca acagacgggt 6840 ctgacatgga ttggacgaac cactgaattg ccgcattgca gagatattgt atttaagtgc 6900 ctagctcgat acataaacgg gtctctctgg ttagaccaga tctgagcctg ggagctctct 6960 ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt gcttcaagta 7020 gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc cttttagtca 7080 gtgtggaaaa tctctagcag tggcgcccga acagggactt gaaagcgaaa gggaaaccag 7140 aggagctctc tcgacgcagg actcggcttg ctgaagcgcg cacggcaaga ggcgaggggc 7200 ggcgactggt gagtacgcca aaaattttga ctagcggagg ctagaaggag agagatgggt 7260 gcgagagcgt cagtattaag cgggggagaa ttagatcgcg atgggaaaaa attcggttaa 7320 ggccaggggg aaagaaaaaa tataaattaa aacatatagt atgggcaagc agggagctag 7380 aacgattcgc agttaatcct ggcctgttag aaacatcaga aggctgtaga caaatactgg 7440 gacagctaca accatccctt cagacaggat cagaagaact tagatcatta tataatacag 7500 tagcaaccct ctattgtgtg catcaaagga tagagataaa agacaccaag gaagctttag 7560 acaagataga ggaagagcaa aacaaaagta agaccaccgc acagcaagcg gccgctgatc 7620 ttcagacctg gaggaggaga tatgagggac aattggagaa gtgaattata taaatataaa 7680 gtagtaaaaa ttgaaccatt aggagtagca cccaccaagg caaagagaag agtggtgcag 7740 agagaaaaaa gagcagtggg aataggagct ttgttccttg ggttcttggg agcagcagga 7800 agcactatgg gcgcagcgtc aatgacgctg acggtacagg ccagacaatt attgtctggt 7860 atagtgcagc agcagaacaa tttgctgagg gctattgagg cgcaacagca tctgttgcaa 7920 ctcacagtct ggggcatcaa gcagctccag gcaagaatcc tggctgtgga aagataccta 7980 aaggatcaac agctcctggg gatttggggt tgctctggaa aactcatttg caccactgct 8040 gtgccttgga atgctagttg gagtaataaa tctctggaac agatttggaa tcacacgacc 8100 tggatggagt gggacagaga aattaacaat tacacaagct taatacactc cttaattgaa 8160 gaatcgcaaa accagcaaga aaagaatgaa caagaattat tggaattaga taaatgggca 8220 agtttgtgga attggtttaa cataacaaat tggctgtggt atataaaatt attcataatg 8280 atagtaggag gcttggtagg tttaagaata gtttttgctg tactttctat agtgaataga 8340 gttaggcagg gatattcacc attatcgttt cagacccacc tcccaacccc gaggggaccc 8400 ttgcgccttt tccaaggcag ccctgggttt gcgcagggac gcggctgctc tgggcgtggt 8460 tccgggaaac gcagcggcgc cgaccctggg tctcgcacat tcttcacgtc cgttcgcagc 8520 gtcacccgga tcttcgccgc tacccttgtg ggccccccgg cgacgcttcc tgctccgccc 8580 ctaagtcggg aaggttcctt gcggttcgcg gcgtgccgga cgtgacaaac ggaagccgca 8640 cgtctcacta gtaccctcgc agacggacag cgccagggag caatggcagc gcgccgaccg 8700 cgatgggctg tggccaatag cggctgctca gcagggcgcg ccgagagcag cggccgggaa 8760 ggggcggtgc gggaggcggg gtgtggggcg gtagtgtggg ccctgttcct gcccgcgcgg 8820 tgttccgcat tctgcaagcc tccggagcgc acgtcggcag tcggctccct cgttgaccga 8880 atcaccgacc tctctcccca gggggtaccc agctgtctag agaattctag atcttgagac 8940 aaatggcagt attcatccac aattttaaaa gaaaaggggg gattgggggg tacagtgcag 9000 gggaaagaat agtagacata atagcaacag acatacaaac taaagaatta caaaaacaaa 9060 ttacaaaaat tcaaaatttt cgggtttatt acagggacag cagagatcca ctttggcgcc 9120 ggctcgaggg gg 9132 <210> 141 <211> 160 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 141 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Glu Ala Met Phe Gly Asp Ser Gln Tyr Glu Val 35 40 45 Ala Asn Ile Phe Phe Trp Arg Pro Trp Leu Ala Cys Met Glu Gln Gln 50 55 60 Thr Arg Tyr Phe Glu Arg Arg His Pro Glu Leu Ala Gly Ser Pro Arg 65 70 75 80 Leu Arg Ala Tyr Met Leu Arg Ile Gly Leu Asp Gln Leu Tyr Gln Ser 85 90 95 Leu Val Asp Gly Asn Phe Asp Asp Ala Ala Trp Ala Gln Gly Arg Cys 100 105 110 Asp Ala Ile Val Arg Ser Gly Ala Gly Thr Val Gly Arg Thr Gln Ile 115 120 125 Ala Arg Arg Ser Ala Ala Val Trp Thr Asp Gly Cys Val Glu Val Leu 130 135 140 Ala Asp Ser Gly Asn Arg Arg Pro Ser Thr Arg Pro Arg Ala Lys Glu 145 150 155 160 <210> 142 <211> 9729 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 142 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaaaaagcc tgaactcacc 660 gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 720 ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc 780 ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt 840 gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaatttag cgagagcctg 900 acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa 960 ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt 1020 agccagacga gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg 1080 cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac tgtgatggac 1140 gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc tgatgctttg ggccgaggac 1200 tgccccgaag tccggcacct cgtgcacgcg gatttcggct ccaacaatgt cctgacggac 1260 aatggccgca taacagcggt cattgactgg agcgaggcga tgttcgggga ttcccaatac 1320 gaggtcgcca acatcttctt ctggaggccg tggttggctt gtatggagca gcagacgcgc 1380 tacttcgagc ggaggcatcc ggagcttgca ggatcgtgcc tttcatacga gaccgagatc 1440 ctgactgtcg agtacggatt gcttcctatc ggcaaaatcg tggagaagag gattgaatgt 1500 accgtctatt cagtcgataa taatgggaac atctacacac agcccgtggc tcaatggcac 1560 gacagaggag agcaggaagt ttttgaatac tgtctcgagg acggatccct catccgcgct 1620 actaaagatc ataagtttat gaccgtggac ggccagatgc tgccaattga cgaaattttt 1680 gaacgagagc tggatctgat gagagtcgac aaccttccaa actgattaat taagaattcg 1740 acccagcttt cttgtacaaa gtggttggta agcctatccc taaccctctc ctcggtctcg 1800 attctacgta gtaatgagct agcagtctcg aggttaacga attccgcccc ccccctaacg 1860 ttactggccg aagccgcttg gaataaggcc ggtgtgcgct tgtctatatg ttattttcca 1920 ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga 1980 gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga 2040 aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca 2100 ggcagcggaa ccccccacct ggcgacaggt gcccctgcgg ccaaaagcca cgtgtataag 2160 atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa 2220 gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac 2280 cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga 2340 ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac 2400 gataatacca tggccatgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 2460 gagggcaccg tggacaacca tcacttcaag tgcacatccg agggcgaagg caagccctac 2520 gagggcaccc agaccatgag aatcaaggtg gtcgagggcg gccctctccc cttcgccttc 2580 gacatcctgg ctactagctt cctctacggc agcaagacct tcatcaacca cacccagggc 2640 atccccgact tcttcaagca gtccttccct gagggcttca catgggagag agtcaccaca 2700 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 2760 atctacaacg tcaagatcag aggggtgaac ttcacatcca acggccctgt gatgcagaag 2820 aaaacactcg gctgggaggc cttcaccgag acgctgtacc ccgctgacgg cggcctggaa 2880 ggcagaaacg acatggccct gaagctcgtg ggcgggagcc atctgatcgc aaacatcaag 2940 accacatata gatccaagaa acccgctaag aacctcaaga tgcctggcgt ctactatgtg 3000 gactacagac tggaaagaat caaggaggcc aacaacgaga cctacgtcga gcagcacgag 3060 gtggcagtgg ccagatactg cgacctccct agcaaactgg ggcacaagct taattaacac 3120 cggtggcgcg ttaagtcgac aatcaacctc tggattacaa aatttgtgaa agattgactg 3180 gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt 3240 atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc 3300 tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt 3360 ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga 3420 ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct 3480 gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat 3540 cgtcctttcc ttggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct 3600 gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc 3660 tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg 3720 cctccccgcg tcgactttaa gaccaatgac ttacaaggca gctgtagatc ttagccactt 3780 tttaaaagaa aaggggggac tggaagggct aattcactcc caacgaagac aagatctgct 3840 ttttgcttgt actgggtctc tctggttaga ccagatctga gcctgggagc tctctggcta 3900 actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc aagtagtgtg 3960 tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt agtcagtgtg 4020 gaaaatctct agcagtacgt atagtagttc atgtcatctt attattcagt atttataact 4080 tgcaaagaaa tgaatatcag agagtgagag gaacttgttt attgcagctt ataatggtta 4140 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 4200 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggctctagc tatcccgccc 4260 ctaactccgc ccatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc 4320 tgactaattt tttttattta tgcagaggcc gaggccgcct cggcctctga gctattccag 4380 aagtagtgag gaggcttttt tggaggccta gggacgtacc caattcgccc tatagtgagt 4440 cgtattacgc gcgctcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg 4500 ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag 4560 aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgggacgcgc 4620 cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac 4680 ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg 4740 ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt 4800 tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc 4860 cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct 4920 tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga 4980 ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga 5040 attttaacaa aatattaacg cttacaattt aggtggcact tttcggggaa atgtgcgcgg 5100 aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata 5160 accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg 5220 tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac 5280 gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact 5340 ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat 5400 gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga 5460 gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac 5520 agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat 5580 gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac 5640 cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct 5700 gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac 5760 gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga 5820 ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg 5880 gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact 5940 ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac 6000 tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta 6060 actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt 6120 taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga 6180 gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc 6240 tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt 6300 ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc 6360 gcagatacca aatactgttc ttctagtgta gccgtagtta ggccaccact tcaagaactc 6420 tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg 6480 cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg 6540 gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga 6600 actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc 6660 ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg 6720 gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg 6780 atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt 6840 tttacggttc ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc 6900 tgattctgtg gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg 6960 aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc 7020 gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt ttcccgactg 7080 gaaagcgggc agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca 7140 ggctttacac tttatgcttc cggctcgtat gttgtgtgga attgtgagcg gataacaatt 7200 tcacacagga aacagctatg accatgatta cgccaagcgc gcaattaacc ctcactaaag 7260 ggaacaaaag ctggagctgc aagcttaatg tagtcttatg caatactctt gtagtcttgc 7320 aacatggtaa cgatgagtta gcaacatgcc ttacaaggag agaaaaagca ccgtgcatgc 7380 cgattggtgg aagtaaggtg gtacgatcgt gccttattag gaaggcaaca gacgggtctg 7440 acatggattg gacgaaccac tgaattgccg cattgcagag atattgtatt taagtgccta 7500 gctcgataca taaacgggtc tctctggtta gaccagatct gagcctggga gctctctggc 7560 taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg 7620 tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg 7680 tggaaaatct ctagcagtgg cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg 7740 agctctctcg acgcaggact cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc 7800 gactggtgag tacgccaaaa attttgacta gcggaggcta gaaggagaga gatgggtgcg 7860 agagcgtcag tattaagcgg gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc 7920 cagggggaaa gaaaaaatat aaattaaaac atatagtatg ggcaagcagg gagctagaac 7980 gattcgcagt taatcctggc ctgttagaaa catcagaagg ctgtagacaa atactgggac 8040 agctacaacc atcccttcag acaggatcag aagaacttag atcattatat aatacagtag 8100 caaccctcta ttgtgtgcat caaaggatag agataaaaga caccaaggaa gctttagaca 8160 agatagagga agagcaaaac aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc 8220 agacctggag gaggagatat gagggacaat tggagaagtg aattatataa atataaagta 8280 gtaaaaattg aaccattagg agtagcaccc accaaggcaa agagaagagt ggtgcagaga 8340 gaaaaaagag cagtgggaat aggagctttg ttccttgggt tcttgggagc agcaggaagc 8400 actatgggcg cagcgtcaat gacgctgacg gtacaggcca gacaattatt gtctggtata 8460 gtgcagcagc agaacaattt gctgagggct attgaggcgc aacagcatct gttgcaactc 8520 acagtctggg gcatcaagca gctccaggca agaatcctgg ctgtggaaag atacctaaag 8580 gatcaacagc tcctggggat ttggggttgc tctggaaaac tcatttgcac cactgctgtg 8640 ccttggaatg ctagttggag taataaatct ctggaacaga tttggaatca cacgacctgg 8700 atggagtggg acagagaaat taacaattac acaagcttaa tacactcctt aattgaagaa 8760 tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg aattagataa atgggcaagt 8820 ttgtggaatt ggtttaacat aacaaattgg ctgtggtata taaaattatt cataatgata 8880 gtaggaggct tggtaggttt aagaatagtt tttgctgtac tttctatagt gaatagagtt 8940 aggcagggat attcaccatt atcgtttcag acccacctcc caaccccgag gggacccttg 9000 cgccttttcc aaggcagccc tgggtttgcg cagggacgcg gctgctctgg gcgtggttcc 9060 gggaaacgca gcggcgccga ccctgggtct cgcacattct tcacgtccgt tcgcagcgtc 9120 acccggatct tcgccgctac ccttgtgggc cccccggcga cgcttcctgc tccgccccta 9180 agtcgggaag gttccttgcg gttcgcggcg tgccggacgt gacaaacgga agccgcacgt 9240 ctcactagta ccctcgcaga cggacagcgc cagggagcaa tggcagcgcg ccgaccgcga 9300 tgggctgtgg ccaatagcgg ctgctcagca gggcgcgccg agagcagcgg ccgggaaggg 9360 gcggtgcggg aggcggggtg tggggcggta gtgtgggccc tgttcctgcc cgcgcggtgt 9420 tccgcattct gcaagcctcc ggagcgcacg tcggcagtcg gctccctcgt tgaccgaatc 9480 accgacctct ctccccaggg ggtacccagc tgtctagaga attctagatc ttgagacaaa 9540 tggcagtatt catccacaat tttaaaagaa aaggggggat tggggggtac agtgcagggg 9600 aaagaatagt agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta 9660 caaaaattca aaattttcgg gtttattaca gggacagcag agatccactt tggcgccggc 9720 tcgaggggg 9729 <210> 143 <211> 361 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 143 Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe Leu Ile 1 5 10 15 Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 20 25 30 Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 35 40 45 Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 50 55 60 Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 65 70 75 80 Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala Gln 85 90 95 Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu 100 105 110 Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser 115 120 125 Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr 130 135 140 Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr 145 150 155 160 His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln 165 170 175 Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg 180 185 190 His Leu Val His Ala Asp Phe Gly Ser Asn Asn Val Leu Thr Asp Asn 195 200 205 Gly Arg Ile Thr Ala Val Ile Asp Trp Ser Glu Ala Met Phe Gly Asp 210 215 220 Ser Gln Tyr Glu Val Ala Asn Ile Phe Phe Trp Arg Pro Trp Leu Ala 225 230 235 240 Cys Met Glu Gln Gln Thr Arg Tyr Phe Glu Arg Arg His Pro Glu Leu 245 250 255 Ala Gly Ser Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr 260 265 270 Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr 275 280 285 Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala 290 295 300 Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu 305 310 315 320 Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val 325 330 335 Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp 340 345 350 Leu Met Arg Val Asp Asn Leu Pro Asn 355 360 <210> 144 <211> 9009 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 144 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcccgcggc tccgggcgta tatgctccgc 780 attggtcttg accaactcta tcagagcttg gttgacggca atttcgatga tgcagcttgg 840 gcgcagggtc gatgcgacgc aatcgtccga tccggagccg ggactgtcgg gcgtacacaa 900 atcgcccgca gaagcgcggc cgtctggacc gatggctgtg tagaagtact cgccgatagt 960 ggaaaccgac gccccagcac tcgtccgagg gcaaaggaat agttaattaa gaattcgacc 1020 cagctttctt gtacaaagtg gttggtaagc ctatccctaa ccctctcctc ggtctcgatt 1080 ctacgtagta atgagctagc agtctcgagg ttaacgaatt ccgccccccc cctaacgtta 1140 ctggccgaag ccgcttggaa taaggccggt gtgcgcttgt ctatatgtta ttttccacca 1200 tattgccgtc ttttggcaat gtgagggccc ggaaacctgg ccctgtcttc ttgacgagca 1260 ttcctagggg tctttcccct ctcgccaaag gaatgcaagg tctgttgaat gtcgtgaagg 1320 aagcagttcc tctggaagct tcttgaagac aaacaacgtc tgtagcgacc ctttgcaggc 1380 agcggaaccc cccacctggc gacaggtgcc cctgcggcca aaagccacgt gtataagata 1440 cacctgcaaa ggcggcacaa ccccagtgcc acgttgtgag ttggatagtt gtggaaagag 1500 tcaaatggct ctcctcaagc gtattcaaca aggggctgaa ggatgcccag aaggtacccc 1560 attgtatggg atctgatctg gggcctcggt gcacatgctt tacatgtgtt tagtcgaggt 1620 taaaaaaacg tctaggcccc ccgaaccacg gggacgtggt tttcctttga aaaacacgat 1680 aataccatgg tgagcaaggg cgaggaggat aacatggcca tcatcaagga gttcatgcgc 1740 ttcaaggtgc acatggaggg ctccgtgaac ggccacgagt tcgagatcga gggcgagggc 1800 gagggccgcc cctacgaggg cacccagacc gccaagctga aggtgaccaa gggtggcccc 1860 ctgcccttcg cctgggacat cctgtcccct cagttcatgt acggctccaa ggcctacgtg 1920 aagcaccccg ccgacatccc cgactacttg aagctgtcct tccccgaggg cttcaagtgg 1980 gagcgcgtga tgaacttcga ggacggcggc gtggtgaccg tgacccagga ctcctccctg 2040 caggacggcg agttcatcta caaggtgaag ctgcgcggca ccaacttccc ctccgacggc 2100 cccgtaatgc agaagaagac catgggctgg gaggcctcct ccgagcggat gtaccccgag 2160 gacggcgccc tgaagggcga gatcaagcag aggctgaagc tgaaggacgg cggccactac 2220 gacgctgagg tcaagaccac ctacaaggcc aagaagcccg tgcagctgcc cggcgcctac 2280 aacgtcaaca tcaagttgga catcacctcc cacaacgagg actacaccat cgtggaacag 2340 tacgaacgcg ccgagggccg ccactccacc ggcggcatgg acgagctgta caagtaacac 2400 cggtggcgcg ttaagtcgac aatcaacctc tggattacaa aatttgtgaa agattgactg 2460 gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt 2520 atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc 2580 tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt 2640 ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga 2700 ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct 2760 gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat 2820 cgtcctttcc ttggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct 2880 gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc 2940 tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg 3000 cctccccgcg tcgactttaa gaccaatgac ttacaaggca gctgtagatc ttagccactt 3060 tttaaaagaa aaggggggac tggaagggct aattcactcc caacgaagac aagatctgct 3120 ttttgcttgt actgggtctc tctggttaga ccagatctga gcctgggagc tctctggcta 3180 actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc aagtagtgtg 3240 tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt agtcagtgtg 3300 gaaaatctct agcagtacgt atagtagttc atgtcatctt attattcagt atttataact 3360 tgcaaagaaa tgaatatcag agagtgagag gaacttgttt attgcagctt ataatggtta 3420 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 3480 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggctctagc tatcccgccc 3540 ctaactccgc ccatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc 3600 tgactaattt tttttattta tgcagaggcc gaggccgcct cggcctctga gctattccag 3660 aagtagtgag gaggcttttt tggaggccta gggacgtacc caattcgccc tatagtgagt 3720 cgtattacgc gcgctcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg 3780 ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag 3840 aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgggacgcgc 3900 cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac 3960 ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg 4020 ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt 4080 tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc 4140 cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct 4200 tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga 4260 ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga 4320 attttaacaa aatattaacg cttacaattt aggtggcact tttcggggaa atgtgcgcgg 4380 aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata 4440 accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg 4500 tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac 4560 gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact 4620 ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat 4680 gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga 4740 gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac 4800 agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat 4860 gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac 4920 cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct 4980 gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac 5040 gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga 5100 ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg 5160 gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact 5220 ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac 5280 tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta 5340 actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt 5400 taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga 5460 gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc 5520 tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt 5580 ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc 5640 gcagatacca aatactgttc ttctagtgta gccgtagtta ggccaccact tcaagaactc 5700 tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg 5760 cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg 5820 gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga 5880 actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc 5940 ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg 6000 gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg 6060 atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt 6120 tttacggttc ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc 6180 tgattctgtg gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg 6240 aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc 6300 gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt ttcccgactg 6360 gaaagcgggc agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca 6420 ggctttacac tttatgcttc cggctcgtat gttgtgtgga attgtgagcg gataacaatt 6480 tcacacagga aacagctatg accatgatta cgccaagcgc gcaattaacc ctcactaaag 6540 ggaacaaaag ctggagctgc aagcttaatg tagtcttatg caatactctt gtagtcttgc 6600 aacatggtaa cgatgagtta gcaacatgcc ttacaaggag agaaaaagca ccgtgcatgc 6660 cgattggtgg aagtaaggtg gtacgatcgt gccttattag gaaggcaaca gacgggtctg 6720 acatggattg gacgaaccac tgaattgccg cattgcagag atattgtatt taagtgccta 6780 gctcgataca taaacgggtc tctctggtta gaccagatct gagcctggga gctctctggc 6840 taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg 6900 tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg 6960 tggaaaatct ctagcagtgg cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg 7020 agctctctcg acgcaggact cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc 7080 gactggtgag tacgccaaaa attttgacta gcggaggcta gaaggagaga gatgggtgcg 7140 agagcgtcag tattaagcgg gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc 7200 cagggggaaa gaaaaaatat aaattaaaac atatagtatg ggcaagcagg gagctagaac 7260 gattcgcagt taatcctggc ctgttagaaa catcagaagg ctgtagacaa atactgggac 7320 agctacaacc atcccttcag acaggatcag aagaacttag atcattatat aatacagtag 7380 caaccctcta ttgtgtgcat caaaggatag agataaaaga caccaaggaa gctttagaca 7440 agatagagga agagcaaaac aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc 7500 agacctggag gaggagatat gagggacaat tggagaagtg aattatataa atataaagta 7560 gtaaaaattg aaccattagg agtagcaccc accaaggcaa agagaagagt ggtgcagaga 7620 gaaaaaagag cagtgggaat aggagctttg ttccttgggt tcttgggagc agcaggaagc 7680 actatgggcg cagcgtcaat gacgctgacg gtacaggcca gacaattatt gtctggtata 7740 gtgcagcagc agaacaattt gctgagggct attgaggcgc aacagcatct gttgcaactc 7800 acagtctggg gcatcaagca gctccaggca agaatcctgg ctgtggaaag atacctaaag 7860 gatcaacagc tcctggggat ttggggttgc tctggaaaac tcatttgcac cactgctgtg 7920 ccttggaatg ctagttggag taataaatct ctggaacaga tttggaatca cacgacctgg 7980 atggagtggg acagagaaat taacaattac acaagcttaa tacactcctt aattgaagaa 8040 tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg aattagataa atgggcaagt 8100 ttgtggaatt ggtttaacat aacaaattgg ctgtggtata taaaattatt cataatgata 8160 gtaggaggct tggtaggttt aagaatagtt tttgctgtac tttctatagt gaatagagtt 8220 aggcagggat attcaccatt atcgtttcag acccacctcc caaccccgag gggacccttg 8280 cgccttttcc aaggcagccc tgggtttgcg cagggacgcg gctgctctgg gcgtggttcc 8340 gggaaacgca gcggcgccga ccctgggtct cgcacattct tcacgtccgt tcgcagcgtc 8400 acccggatct tcgccgctac ccttgtgggc cccccggcga cgcttcctgc tccgccccta 8460 agtcgggaag gttccttgcg gttcgcggcg tgccggacgt gacaaacgga agccgcacgt 8520 ctcactagta ccctcgcaga cggacagcgc cagggagcaa tggcagcgcg ccgaccgcga 8580 tgggctgtgg ccaatagcgg ctgctcagca gggcgcgccg agagcagcgg ccgggaaggg 8640 gcggtgcggg aggcggggtg tggggcggta gtgtgggccc tgttcctgcc cgcgcggtgt 8700 tccgcattct gcaagcctcc ggagcgcacg tcggcagtcg gctccctcgt tgaccgaatc 8760 accgacctct ctccccaggg ggtacccagc tgtctagaga attctagatc ttgagacaaa 8820 tggcagtatt catccacaat tttaaaagaa aaggggggat tggggggtac agtgcagggg 8880 aaagaatagt agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta 8940 caaaaattca aaattttcgg gtttattaca gggacagcag agatccactt tggcgccggc 9000 tcgaggggg 9009 <210> 145 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 145 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Pro Arg Leu Arg Ala Tyr Met Leu Arg Ile Gly 35 40 45 Leu Asp Gln Leu Tyr Gln Ser Leu Val Asp Gly Asn Phe Asp Asp Ala 50 55 60 Ala Trp Ala Gln Gly Arg Cys Asp Ala Ile Val Arg Ser Gly Ala Gly 65 70 75 80 Thr Val Gly Arg Thr Gln Ile Ala Arg Arg Ser Ala Ala Val Trp Thr 85 90 95 Asp Gly Cys Val Glu Val Leu Ala Asp Ser Gly Asn Arg Arg Pro Ser 100 105 110 Thr Arg Pro Arg Ala Lys Glu 115 <210> 146 <211> 9783 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 146 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaaaaagcc tgaactcacc 660 gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 720 ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc 780 ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt 840 gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaatttag cgagagcctg 900 acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa 960 ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt 1020 agccagacga gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg 1080 cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac tgtgatggac 1140 gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc tgatgctttg ggccgaggac 1200 tgccccgaag tccggcacct cgtgcacgcg gatttcggct ccaacaatgt cctgacggac 1260 aatggccgca taacagcggt cattgactgg agcgaggcga tgttcgggga ttcccaatac 1320 gaggtcgcca acatcttctt ctggaggccg tggttggctt gtatggagca gcagacgcgc 1380 tacttcgagc ggaggcatcc ggagcttgca ggatcgccgc ggctccgggc gtatatgctc 1440 cgcattggtc ttgaccaact ctatcagagc tgcctttcat acgagaccga gatcctgact 1500 gtcgagtacg gattgcttcc tatcggcaaa atcgtggaga agaggattga atgtaccgtc 1560 tattcagtcg ataataatgg gaacatctac acacagcccg tggctcaatg gcacgacaga 1620 ggagagcagg aagtttttga atactgtctc gaggacggat ccctcatccg cgctactaaa 1680 gatcataagt ttatgaccgt ggacggccag atgctgccaa ttgacgaaat ttttgaacga 1740 gagctggatc tgatgagagt cgacaacctt ccaaactgat taattaagaa ttcgacccag 1800 ctttcttgta caaagtggtt ggtaagccta tccctaaccc tctcctcggt ctcgattcta 1860 cgtagtaatg agctagcagt ctcgaggtta acgaattccg ccccccccct aacgttactg 1920 gccgaagccg cttggaataa ggccggtgtg cgcttgtcta tatgttattt tccaccatat 1980 tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc 2040 ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag 2100 cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc 2160 ggaacccccc acctggcgac aggtgcccct gcggccaaaa gccacgtgta taagatacac 2220 ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca 2280 aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt 2340 gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa 2400 aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgataat 2460 accatggcca tgagcgagct gattaaggag aacatgcaca tgaagctgta catggagggc 2520 accgtggaca accatcactt caagtgcaca tccgagggcg aaggcaagcc ctacgagggc 2580 acccagacca tgagaatcaa ggtggtcgag ggcggccctc tccccttcgc cttcgacatc 2640 ctggctacta gcttcctcta cggcagcaag accttcatca accacaccca gggcatcccc 2700 gacttcttca agcagtcctt ccctgagggc ttcacatggg agagagtcac cacatacgaa 2760 gacgggggcg tgctgaccgc tacccaggac accagcctcc aggacggctg cctcatctac 2820 aacgtcaaga tcagaggggt gaacttcaca tccaacggcc ctgtgatgca gaagaaaaca 2880 ctcggctggg aggccttcac cgagacgctg taccccgctg acggcggcct ggaaggcaga 2940 aacgacatgg ccctgaagct cgtgggcggg agccatctga tcgcaaacat caagaccaca 3000 tatagatcca agaaacccgc taagaacctc aagatgcctg gcgtctacta tgtggactac 3060 agactggaaa gaatcaagga ggccaacaac gagacctacg tcgagcagca cgaggtggca 3120 gtggccagat actgcgacct ccctagcaaa ctggggcaca agcttaatta acaccggtgg 3180 cgcgttaagt cgacaatcaa cctctggatt acaaaatttg tgaaagattg actggtattc 3240 ttaactatgt tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg 3300 ctattgcttc ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc 3360 tttatgagga gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg 3420 acgcaacccc cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg 3480 ctttccccct ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga 3540 caggggctcg gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct 3600 ttccttggct gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg 3660 tcccttcggc cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc 3720 ctcttccgcg tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc 3780 cgcgtcgact ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa 3840 agaaaagggg ggactggaag ggctaattca ctcccaacga agacaagatc tgctttttgc 3900 ttgtactggg tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg 3960 gaacccactg cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg 4020 tctgttgtgt gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat 4080 ctctagcagt acgtatagta gttcatgtca tcttattatt cagtatttat aacttgcaaa 4140 gaaatgaata tcagagagtg agaggaactt gtttattgca gcttataatg gttacaaata 4200 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 4260 tttgtccaaa ctcatcaatg tatcttatca tgtctggctc tagctatccc gcccctaact 4320 ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta 4380 atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt ccagaagtag 4440 tgaggaggct tttttggagg cctagggacg tacccaattc gccctatagt gagtcgtatt 4500 acgcgcgctc actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc 4560 aacttaatcg ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc 4620 gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatgggac gcgccctgta 4680 gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca 4740 gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct 4800 ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc 4860 acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat 4920 agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc 4980 aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc 5040 cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta 5100 acaaaatatt aacgcttaca atttaggtgg cacttttcgg ggaaatgtgc gcggaacccc 5160 tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg 5220 ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc 5280 ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt 5340 gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct 5400 caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac 5460 ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact 5520 cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa 5580 gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga 5640 taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt 5700 tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga 5760 agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg 5820 caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat 5880 ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat 5940 tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc 6000 agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga 6060 tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc 6120 agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag 6180 gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc 6240 gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt 6300 tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt 6360 gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat 6420 accaaatact gttcttctag tgtagccgta gttaggccac cacttcaaga actctgtagc 6480 accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa 6540 gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg 6600 ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag 6660 atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag 6720 gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa 6780 cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt 6840 gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg 6900 gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc 6960 tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac 7020 cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct 7080 ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc 7140 gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt 7200 acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac 7260 aggaaacagc tatgaccatg attacgccaa gcgcgcaatt aaccctcact aaagggaaca 7320 aaagctggag ctgcaagctt aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg 7380 gtaacgatga gttagcaaca tgccttacaa ggagagaaaa agcaccgtgc atgccgattg 7440 gtggaagtaa ggtggtacga tcgtgcctta ttaggaaggc aacagacggg tctgacatgg 7500 attggacgaa ccactgaatt gccgcattgc agagatattg tatttaagtg cctagctcga 7560 tacataaacg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta 7620 gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc 7680 cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa 7740 atctctagca gtggcgcccg aacagggact tgaaagcgaa agggaaacca gaggagctct 7800 ctcgacgcag gactcggctt gctgaagcgc gcacggcaag aggcgagggg cggcgactgg 7860 tgagtacgcc aaaaattttg actagcggag gctagaagga gagagatggg tgcgagagcg 7920 tcagtattaa gcgggggaga attagatcgc gatgggaaaa aattcggtta aggccagggg 7980 gaaagaaaaa atataaatta aaacatatag tatgggcaag cagggagcta gaacgattcg 8040 cagttaatcc tggcctgtta gaaacatcag aaggctgtag acaaatactg ggacagctac 8100 aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca gtagcaaccc 8160 tctattgtgt gcatcaaagg atagagataa aagacaccaa ggaagcttta gacaagatag 8220 aggaagagca aaacaaaagt aagaccaccg cacagcaagc ggccgctgat cttcagacct 8280 ggaggaggag atatgaggga caattggaga agtgaattat ataaatataa agtagtaaaa 8340 attgaaccat taggagtagc acccaccaag gcaaagagaa gagtggtgca gagagaaaaa 8400 agagcagtgg gaataggagc tttgttcctt gggttcttgg gagcagcagg aagcactatg 8460 ggcgcagcgt caatgacgct gacggtacag gccagacaat tattgtctgg tatagtgcag 8520 cagcagaaca atttgctgag ggctattgag gcgcaacagc atctgttgca actcacagtc 8580 tggggcatca agcagctcca ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa 8640 cagctcctgg ggatttgggg ttgctctgga aaactcattt gcaccactgc tgtgccttgg 8700 aatgctagtt ggagtaataa atctctggaa cagatttgga atcacacgac ctggatggag 8760 tgggacagag aaattaacaa ttacacaagc ttaatacact ccttaattga agaatcgcaa 8820 aaccagcaag aaaagaatga acaagaatta ttggaattag ataaatgggc aagtttgtgg 8880 aattggttta acataacaaa ttggctgtgg tatataaaat tattcataat gatagtagga 8940 ggcttggtag gtttaagaat agtttttgct gtactttcta tagtgaatag agttaggcag 9000 ggatattcac cattatcgtt tcagacccac ctcccaaccc cgaggggacc cttgcgcctt 9060 ttccaaggca gccctgggtt tgcgcaggga cgcggctgct ctgggcgtgg ttccgggaaa 9120 cgcagcggcg ccgaccctgg gtctcgcaca ttcttcacgt ccgttcgcag cgtcacccgg 9180 atcttcgccg ctacccttgt gggccccccg gcgacgcttc ctgctccgcc cctaagtcgg 9240 gaaggttcct tgcggttcgc ggcgtgccgg acgtgacaaa cggaagccgc acgtctcact 9300 agtaccctcg cagacggaca gcgccaggga gcaatggcag cgcgccgacc gcgatgggct 9360 gtggccaata gcggctgctc agcagggcgc gccgagagca gcggccggga aggggcggtg 9420 cgggaggcgg ggtgtggggc ggtagtgtgg gccctgttcc tgcccgcgcg gtgttccgca 9480 ttctgcaagc ctccggagcg cacgtcggca gtcggctccc tcgttgaccg aatcaccgac 9540 ctctctcccc agggggtacc cagctgtcta gagaattcta gatcttgaga caaatggcag 9600 tattcatcca caattttaaa agaaaagggg ggattggggg gtacagtgca ggggaaagaa 9660 tagtagacat aatagcaaca gacatacaaa ctaaagaatt acaaaaacaa attacaaaaa 9720 ttcaaaattt tcgggtttat tacagggaca gcagagatcc actttggcgc cggctcgagg 9780 ggg 9783 <210> 147 <211> 379 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 147 Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe Leu Ile 1 5 10 15 Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 20 25 30 Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 35 40 45 Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 50 55 60 Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 65 70 75 80 Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala Gln 85 90 95 Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu 100 105 110 Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser 115 120 125 Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr 130 135 140 Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr 145 150 155 160 His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln 165 170 175 Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg 180 185 190 His Leu Val His Ala Asp Phe Gly Ser Asn Asn Val Leu Thr Asp Asn 195 200 205 Gly Arg Ile Thr Ala Val Ile Asp Trp Ser Glu Ala Met Phe Gly Asp 210 215 220 Ser Gln Tyr Glu Val Ala Asn Ile Phe Phe Trp Arg Pro Trp Leu Ala 225 230 235 240 Cys Met Glu Gln Gln Thr Arg Tyr Phe Glu Arg Arg His Pro Glu Leu 245 250 255 Ala Gly Ser Pro Arg Leu Arg Ala Tyr Met Leu Arg Ile Gly Leu Asp 260 265 270 Gln Leu Tyr Gln Ser Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val 275 280 285 Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu 290 295 300 Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro 305 310 315 320 Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys 325 330 335 Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met 340 345 350 Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu 355 360 365 Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn 370 375 <210> 148 <211> 8955 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 148 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcttggttg acggcaattt cgatgatgca 780 gcttgggcgc agggtcgatg cgacgcaatc gtccgatccg gagccgggac tgtcgggcgt 840 acacaaatcg cccgcagaag cgcggccgtc tggaccgatg gctgtgtaga agtactcgcc 900 gatagtggaa accgacgccc cagcactcgt ccgagggcaa aggaatagtt aattaagaat 960 tcgacccagc tttcttgtac aaagtggttg gtaagcctat ccctaaccct ctcctcggtc 1020 tcgattctac gtagtaatga gctagcagtc tcgaggttaa cgaattccgc ccccccccta 1080 acgttactgg ccgaagccgc ttggaataag gccggtgtgc gcttgtctat atgttatttt 1140 ccaccatatt gccgtctttt ggcaatgtga gggcccggaa acctggccct gtcttcttga 1200 cgagcattcc taggggtctt tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg 1260 tgaaggaagc agttcctctg gaagcttctt gaagacaaac aacgtctgta gcgacccttt 1320 gcaggcagcg gaacccccca cctggcgaca ggtgcccctg cggccaaaag ccacgtgtat 1380 aagatacacc tgcaaaggcg gcacaacccc agtgccacgt tgtgagttgg atagttgtgg 1440 aaagagtcaa atggctctcc tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg 1500 taccccattg tatgggatct gatctggggc ctcggtgcac atgctttaca tgtgtttagt 1560 cgaggttaaa aaaacgtcta ggccccccga accacgggga cgtggttttc ctttgaaaaa 1620 cacgataata ccatggtgag caagggcgag gaggataaca tggccatcat caaggagttc 1680 atgcgcttca aggtgcacat ggagggctcc gtgaacggcc acgagttcga gatcgagggc 1740 gagggcgagg gccgccccta cgagggcacc cagaccgcca agctgaaggt gaccaagggt 1800 ggccccctgc ccttcgcctg ggacatcctg tcccctcagt tcatgtacgg ctccaaggcc 1860 tacgtgaagc accccgccga catccccgac tacttgaagc tgtccttccc cgagggcttc 1920 aagtgggagc gcgtgatgaa cttcgaggac ggcggcgtgg tgaccgtgac ccaggactcc 1980 tccctgcagg acggcgagtt catctacaag gtgaagctgc gcggcaccaa cttcccctcc 2040 gacggccccg taatgcagaa gaagaccatg ggctgggagg cctcctccga gcggatgtac 2100 cccgaggacg gcgccctgaa gggcgagatc aagcagaggc tgaagctgaa ggacggcggc 2160 cactacgacg ctgaggtcaa gaccacctac aaggccaaga agcccgtgca gctgcccggc 2220 gcctacaacg tcaacatcaa gttggacatc acctcccaca acgaggacta caccatcgtg 2280 gaacagtacg aacgcgccga gggccgccac tccaccggcg gcatggacga gctgtacaag 2340 taacaccggt ggcgcgttaa gtcgacaatc aacctctgga ttacaaaatt tgtgaaagat 2400 tgactggtat tcttaactat gttgctcctt ttacgctatg tggatacgct gctttaatgc 2460 ctttgtatca tgctattgct tcccgtatgg ctttcatttt ctcctccttg tataaatcct 2520 ggttgctgtc tctttatgag gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca 2580 ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc caccacctgt cagctccttt 2640 ccgggacttt cgctttcccc ctccctattg ccacggcgga actcatcgcc gcctgccttg 2700 cccgctgctg gacaggggct cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga 2760 aatcatcgtc ctttccttgg ctgctcgcct gtgttgccac ctggattctg cgcgggacgt 2820 ccttctgcta cgtcccttcg gccctcaatc cagcggacct tccttcccgc ggcctgctgc 2880 cggctctgcg gcctcttccg cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt 2940 gggccgcctc cccgcgtcga ctttaagacc aatgacttac aaggcagctg tagatcttag 3000 ccacttttta aaagaaaagg ggggactgga agggctaatt cactcccaac gaagacaaga 3060 tctgcttttt gcttgtactg ggtctctctg gttagaccag atctgagcct gggagctctc 3120 tggctaacta gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt 3180 agtgtgtgcc cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc 3240 agtgtggaaa atctctagca gtacgtatag tagttcatgt catcttatta ttcagtattt 3300 ataacttgca aagaaatgaa tatcagagag tgagaggaac ttgtttattg cagcttataa 3360 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 3420 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctggc tctagctatc 3480 ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc 3540 catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc ctctgagcta 3600 ttccagaagt agtgaggagg cttttttgga ggcctaggga cgtacccaat tcgccctata 3660 gtgagtcgta ttacgcgcgc tcactggccg tcgttttaca acgtcgtgac tgggaaaacc 3720 ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc tggcgtaata 3780 gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggg 3840 acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg 3900 ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca 3960 cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta 4020 gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc 4080 catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg 4140 gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat 4200 aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta 4260 acgcgaattt taacaaaata ttaacgctta caatttaggt ggcacttttc ggggaaatgt 4320 gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag 4380 acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca 4440 tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc 4500 agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat 4560 cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc 4620 aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg 4680 gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc 4740 agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat 4800 aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga 4860 gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc 4920 ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc 4980 aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt 5040 aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc 5100 tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc 5160 agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca 5220 ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca 5280 ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa aacttcattt 5340 ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta 5400 acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg 5460 agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc 5520 ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag 5580 cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc accacttcaa 5640 gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc 5700 cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc 5760 gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta 5820 caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag 5880 aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct 5940 tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga 6000 gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc 6060 ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt 6120 atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg 6180 cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcccaatacg 6240 caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg acaggtttcc 6300 cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca ctcattaggc 6360 accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg tgagcggata 6420 acaatttcac acaggaaaca gctatgacca tgattacgcc aagcgcgcaa ttaaccctca 6480 ctaaagggaa caaaagctgg agctgcaagc ttaatgtagt cttatgcaat actcttgtag 6540 tcttgcaaca tggtaacgat gagttagcaa catgccttac aaggagagaa aaagcaccgt 6600 gcatgccgat tggtggaagt aaggtggtac gatcgtgcct tattaggaag gcaacagacg 6660 ggtctgacat ggattggacg aaccactgaa ttgccgcatt gcagagatat tgtatttaag 6720 tgcctagctc gatacataaa cgggtctctc tggttagacc agatctgagc ctgggagctc 6780 tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgcttcaa 6840 gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag 6900 tcagtgtgga aaatctctag cagtggcgcc cgaacaggga cttgaaagcg aaagggaaac 6960 cagaggagct ctctcgacgc aggactcggc ttgctgaagc gcgcacggca agaggcgagg 7020 ggcggcgact ggtgagtacg ccaaaaattt tgactagcgg aggctagaag gagagagatg 7080 ggtgcgagag cgtcagtatt aagcggggga gaattagatc gcgatgggaa aaaattcggt 7140 taaggccagg gggaaagaaa aaatataaat taaaacatat agtatgggca agcagggagc 7200 tagaacgatt cgcagttaat cctggcctgt tagaaacatc agaaggctgt agacaaatac 7260 tgggacagct acaaccatcc cttcagacag gatcagaaga acttagatca ttatataata 7320 cagtagcaac cctctattgt gtgcatcaaa ggatagagat aaaagacacc aaggaagctt 7380 tagacaagat agaggaagag caaaacaaaa gtaagaccac cgcacagcaa gcggccgctg 7440 atcttcagac ctggaggagg agatatgagg gacaattgga gaagtgaatt atataaatat 7500 aaagtagtaa aaattgaacc attaggagta gcacccacca aggcaaagag aagagtggtg 7560 cagagagaaa aaagagcagt gggaatagga gctttgttcc ttgggttctt gggagcagca 7620 ggaagcacta tgggcgcagc gtcaatgacg ctgacggtac aggccagaca attattgtct 7680 ggtatagtgc agcagcagaa caatttgctg agggctattg aggcgcaaca gcatctgttg 7740 caactcacag tctggggcat caagcagctc caggcaagaa tcctggctgt ggaaagatac 7800 ctaaaggatc aacagctcct ggggatttgg ggttgctctg gaaaactcat ttgcaccact 7860 gctgtgcctt ggaatgctag ttggagtaat aaatctctgg aacagatttg gaatcacacg 7920 acctggatgg agtgggacag agaaattaac aattacacaa gcttaataca ctccttaatt 7980 gaagaatcgc aaaaccagca agaaaagaat gaacaagaat tattggaatt agataaatgg 8040 gcaagtttgt ggaattggtt taacataaca aattggctgt ggtatataaa attattcata 8100 atgatagtag gaggcttggt aggtttaaga atagtttttg ctgtactttc tatagtgaat 8160 agagttaggc agggatattc accattatcg tttcagaccc acctcccaac cccgagggga 8220 cccttgcgcc ttttccaagg cagccctggg tttgcgcagg gacgcggctg ctctgggcgt 8280 ggttccggga aacgcagcgg cgccgaccct gggtctcgca cattcttcac gtccgttcgc 8340 agcgtcaccc ggatcttcgc cgctaccctt gtgggccccc cggcgacgct tcctgctccg 8400 cccctaagtc gggaaggttc cttgcggttc gcggcgtgcc ggacgtgaca aacggaagcc 8460 gcacgtctca ctagtaccct cgcagacgga cagcgccagg gagcaatggc agcgcgccga 8520 ccgcgatggg ctgtggccaa tagcggctgc tcagcagggc gcgccgagag cagcggccgg 8580 gaaggggcgg tgcgggaggc ggggtgtggg gcggtagtgt gggccctgtt cctgcccgcg 8640 cggtgttccg cattctgcaa gcctccggag cgcacgtcgg cagtcggctc cctcgttgac 8700 cgaatcaccg acctctctcc ccagggggta cccagctgtc tagagaattc tagatcttga 8760 gacaaatggc agtattcatc cacaatttta aaagaaaagg ggggattggg gggtacagtg 8820 caggggaaag aatagtagac ataatagcaa cagacataca aactaaagaa ttacaaaaac 8880 aaattacaaa aattcaaaat tttcgggttt attacaggga cagcagagat ccactttggc 8940 gccggctcga ggggg 8955 <210> 149 <211> 101 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 149 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Leu Val Asp Gly Asn Phe Asp Asp Ala Ala Trp 35 40 45 Ala Gln Gly Arg Cys Asp Ala Ile Val Arg Ser Gly Ala Gly Thr Val 50 55 60 Gly Arg Thr Gln Ile Ala Arg Arg Ser Ala Ala Val Trp Thr Asp Gly 65 70 75 80 Cys Val Glu Val Leu Ala Asp Ser Gly Asn Arg Arg Pro Ser Thr Arg 85 90 95 Pro Arg Ala Lys Glu 100 <210> 150 <211> 9048 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 150 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaccgagta caagcccacg 660 gtgcgcctcg ccacccgcga cgacgtcccc agggccgtac gcaccctcgc cgccgcgttc 720 gccgactacc ccgcctgcct ttcatacgag accgagatcc tgactgtcga gtacggattg 780 cttcctatcg gcaaaatcgt ggagaagagg attgaatgta ccgtctattc agtcgataat 840 aatgggaaca tctacacaca gcccgtggct caatggcacg acagaggaga gcaggaagtt 900 tttgaatact gtctcgagga cggatccctc atccgcgcta ctaaagatca taagtttatg 960 accgtggacg gccagatgct gccaattgac gaaatttttg aacgagagct ggatctgatg 1020 agagtcgaca accttccaaa ctgattaatt aagaattcga cccagctttc ttgtacaaag 1080 tggttggtaa gcctatccct aaccctctcc tcggtctcga ttctacgtag taatgagcta 1140 gcagtctcga ggttaacgaa ttccgccccc cccctaacgt tactggccga agccgcttgg 1200 aataaggccg gtgtgcgctt gtctatatgt tattttccac catattgccg tcttttggca 1260 atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg ggtctttccc 1320 ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt cctctggaag 1380 cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac cccccacctg 1440 gcgacaggtg cccctgcggc caaaagccac gtgtataaga tacacctgca aaggcggcac 1500 aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg ctctcctcaa 1560 gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg ggatctgatc 1620 tggggcctcg gtgcacatgc tttacatgtg tttagtcgag gttaaaaaaa cgtctaggcc 1680 ccccgaacca cggggacgtg gttttccttt gaaaaacacg ataataccat ggccatgagc 1740 gagctgatta aggagaacat gcacatgaag ctgtacatgg agggcaccgt ggacaaccat 1800 cacttcaagt gcacatccga gggcgaaggc aagccctacg agggcaccca gaccatgaga 1860 atcaaggtgg tcgagggcgg ccctctcccc ttcgccttcg acatcctggc tactagcttc 1920 ctctacggca gcaagacctt catcaaccac acccagggca tccccgactt cttcaagcag 1980 tccttccctg agggcttcac atgggagaga gtcaccacat acgaagacgg gggcgtgctg 2040 accgctaccc aggacaccag cctccaggac ggctgcctca tctacaacgt caagatcaga 2100 ggggtgaact tcacatccaa cggccctgtg atgcagaaga aaacactcgg ctgggaggcc 2160 ttcaccgaga cgctgtaccc cgctgacggc ggcctggaag gcagaaacga catggccctg 2220 aagctcgtgg gcgggagcca tctgatcgca aacatcaaga ccacatatag atccaagaaa 2280 cccgctaaga acctcaagat gcctggcgtc tactatgtgg actacagact ggaaagaatc 2340 aaggaggcca acaacgagac ctacgtcgag cagcacgagg tggcagtggc cagatactgc 2400 gacctcccta gcaaactggg gcacaagctt aattaacacc ggtggcgcgt taagtcgaca 2460 atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc 2520 cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta 2580 tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt 2640 ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg 2700 gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta 2760 ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt 2820 tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg 2880 cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca 2940 atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc 3000 gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgcgt cgactttaag 3060 accaatgact tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact 3120 ggaagggcta attcactccc aacgaagaca agatctgctt tttgcttgta ctgggtctct 3180 ctggttagac cagatctgag cctgggagct ctctggctaa ctagggaacc cactgcttaa 3240 gcctcaataa agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc 3300 tggtaactag agatccctca gaccctttta gtcagtgtgg aaaatctcta gcagtacgta 3360 tagtagttca tgtcatctta ttattcagta tttataactt gcaaagaaat gaatatcaga 3420 gagtgagagg aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac 3480 aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat 3540 caatgtatct tatcatgtct ggctctagct atcccgcccc taactccgcc catcccgccc 3600 ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat 3660 gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg aggctttttt 3720 ggaggcctag ggacgtaccc aattcgccct atagtgagtc gtattacgcg cgctcactgg 3780 ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 3840 cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 3900 cccaacagtt gcgcagcctg aatggcgaat gggacgcgcc ctgtagcggc gcattaagcg 3960 cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg 4020 ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc 4080 taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa 4140 aacttgatta gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc 4200 ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac 4260 tcaaccctat ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt 4320 ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa atattaacgc 4380 ttacaattta ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt 4440 ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata 4500 atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt 4560 tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc 4620 tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat 4680 ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct 4740 atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc gccgcataca 4800 ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg 4860 catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa 4920 cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg 4980 ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga 5040 cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg 5100 cgaactactt actctagctt cccggcaaca attaatagac tggatggagg cggataaagt 5160 tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg 5220 agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc 5280 ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca 5340 gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc 5400 atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat 5460 cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc 5520 agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg 5580 ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct 5640 accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa atactgttct 5700 tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct 5760 cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg 5820 gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc 5880 gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga 5940 gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg 6000 cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta 6060 tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg 6120 ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg 6180 ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat 6240 taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc 6300 agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg cgcgttggcc 6360 gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa 6420 cgcaattaat gtgagttagc tcactcatta ggcaccccag gctttacact ttatgcttcc 6480 ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa acagctatga 6540 ccatgattac gccaagcgcg caattaaccc tcactaaagg gaacaaaagc tggagctgca 6600 agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag 6660 caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg 6720 tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact 6780 gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacat aaacgggtct 6840 ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt 6900 aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac 6960 tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc 7020 gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc 7080 ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa 7140 ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg 7200 ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata 7260 aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc 7320 tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga 7380 caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc 7440 aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca 7500 aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg 7560 agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga 7620 gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata 7680 ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg 7740 acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg 7800 ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag 7860 ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt 7920 tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt 7980 aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt 8040 aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag 8100 aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata 8160 acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta 8220 agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta 8280 tcgtttcaga cccacctccc aaccccgagg ggacccttgc gccttttcca aggcagccct 8340 gggtttgcgc agggacgcgg ctgctctggg cgtggttccg ggaaacgcag cggcgccgac 8400 cctgggtctc gcacattctt cacgtccgtt cgcagcgtca cccggatctt cgccgctacc 8460 cttgtgggcc ccccggcgac gcttcctgct ccgcccctaa gtcgggaagg ttccttgcgg 8520 ttcgcggcgt gccggacgtg acaaacggaa gccgcacgtc tcactagtac cctcgcagac 8580 ggacagcgcc agggagcaat ggcagcgcgc cgaccgcgat gggctgtggc caatagcggc 8640 tgctcagcag ggcgcgccga gagcagcggc cgggaagggg cggtgcggga ggcggggtgt 8700 ggggcggtag tgtgggccct gttcctgccc gcgcggtgtt ccgcattctg caagcctccg 8760 gagcgcacgt cggcagtcgg ctccctcgtt gaccgaatca ccgacctctc tccccagggg 8820 gtacccagct gtctagagaa ttctagatct tgagacaaat ggcagtattc atccacaatt 8880 ttaaaagaaa aggggggatt ggggggtaca gtgcagggga aagaatagta gacataatag 8940 caacagacat acaaactaaa gaattacaaa aacaaattac aaaaattcaa aattttcggg 9000 tttattacag ggacagcaga gatccacttt ggcgccggct cgaggggg 9048 <210> 151 <211> 134 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 151 Met Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp Asp Val 1 5 10 15 Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr Pro Ala 20 25 30 Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu 35 40 45 Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 50 55 60 Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 65 70 75 80 Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 85 90 95 Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 100 105 110 Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 115 120 125 Val Asp Asn Leu Pro Asn 130 <210> 152 <211> 9264 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 152 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcacgcgcc acaccgtcga tccggaccgc 780 cacatcgagc gggtcaccga gctgcaagaa ctcttcctca cgcgcgtcgg gctcgacatc 840 ggcaaggtgt gggtcgcgga cgacggcgcc gcggtggcgg tctggaccac gccggagagc 900 gtcgaagcgg gggcggtgtt cgccgagatc ggcccgcgca tggccgagtt gagcggttcc 960 cggctggccg cgcagcaaca gatggaaggc ctcctggcgc cgcaccggcc caaggagccc 1020 gcgtggttcc tggccaccgt cggcgtctcg cccgaccacc agggcaaggg tctgggcagc 1080 gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg gggtgcccgc cttcctggag 1140 acctccgcgc cccgcaacct ccccttctac gagcggctcg gcttcaccgt caccgccgac 1200 gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc gcaagcccgg tgcctgatta 1260 attaagaatt cgacccagct ttcttgtaca aagtggttgg taagcctatc cctaaccctc 1320 tcctcggtct cgattctacg tagtaatgag ctagcagtct cgaggttaac gaattccgcc 1380 ccccccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg cttgtctata 1440 tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg 1500 tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg caaggtctgt 1560 tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca acgtctgtag 1620 cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcccctgc ggccaaaagc 1680 cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga 1740 tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg ctgaaggatg 1800 cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca tgctttacat 1860 gtgtttagtc gaggttaaaa aaacgtctag gccccccgaa ccacggggac gtggttttcc 1920 tttgaaaaac acgataatac catggtgagc aagggcgagg aggataacat ggccatcatc 1980 aaggagttca tgcgcttcaa ggtgcacatg gagggctccg tgaacggcca cgagttcgag 2040 atcgagggcg agggcgaggg ccgcccctac gagggcaccc agaccgccaa gctgaaggtg 2100 accaagggtg gccccctgcc cttcgcctgg gacatcctgt cccctcagtt catgtacggc 2160 tccaaggcct acgtgaagca ccccgccgac atccccgact acttgaagct gtccttcccc 2220 gagggcttca agtgggagcg cgtgatgaac ttcgaggacg gcggcgtggt gaccgtgacc 2280 caggactcct ccctgcagga cggcgagttc atctacaagg tgaagctgcg cggcaccaac 2340 ttcccctccg acggccccgt aatgcagaag aagaccatgg gctgggaggc ctcctccgag 2400 cggatgtacc ccgaggacgg cgccctgaag ggcgagatca agcagaggct gaagctgaag 2460 gacggcggcc actacgacgc tgaggtcaag accacctaca aggccaagaa gcccgtgcag 2520 ctgcccggcg cctacaacgt caacatcaag ttggacatca cctcccacaa cgaggactac 2580 accatcgtgg aacagtacga acgcgccgag ggccgccact ccaccggcgg catggacgag 2640 ctgtacaagt aacaccggtg gcgcgttaag tcgacaatca acctctggat tacaaaattt 2700 gtgaaagatt gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg 2760 ctttaatgcc tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt 2820 ataaatcctg gttgctgtct ctttatgagg agttgtggcc cgttgtcagg caacgtggcg 2880 tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg gggcattgcc accacctgtc 2940 agctcctttc cgggactttc gctttccccc tccctattgc cacggcggaa ctcatcgccg 3000 cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt 3060 tgtcggggaa atcatcgtcc tttccttggc tgctcgcctg tgttgccacc tggattctgc 3120 gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg 3180 gcctgctgcc ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga 3240 tctccctttg ggccgcctcc ccgcgtcgac tttaagacca atgacttaca aggcagctgt 3300 agatcttagc cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaacg 3360 aagacaagat ctgctttttg cttgtactgg gtctctctgg ttagaccaga tctgagcctg 3420 ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt 3480 gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc 3540 cttttagtca gtgtggaaaa tctctagcag tacgtatagt agttcatgtc atcttattat 3600 tcagtattta taacttgcaa agaaatgaat atcagagagt gagaggaact tgtttattgc 3660 agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt 3720 ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggct 3780 ctagctatcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat 3840 tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc 3900 tctgagctat tccagaagta gtgaggaggc ttttttggag gcctagggac gtacccaatt 3960 cgccctatag tgagtcgtat tacgcgcgct cactggccgt cgttttacaa cgtcgtgact 4020 gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct 4080 ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg 4140 gcgaatggga cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca 4200 gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct 4260 ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt 4320 tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac 4380 gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct 4440 ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt 4500 ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac 4560 aaaaatttaa cgcgaatttt aacaaaatat taacgcttac aatttaggtg gcacttttcg 4620 gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc 4680 gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag 4740 tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt 4800 tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt 4860 gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga 4920 acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat 4980 tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga 5040 gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag 5100 tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg 5160 accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg 5220 ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt 5280 agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg 5340 gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc 5400 ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg 5460 tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac 5520 ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact 5580 gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa 5640 acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa 5700 aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg 5760 atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc 5820 gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac 5880 tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt agttaggcca 5940 ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt 6000 ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc 6060 ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg 6120 aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc 6180 cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac 6240 gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct 6300 ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc 6360 cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt 6420 tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac 6480 cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg 6540 cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca gctggcacga 6600 caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga gttagctcac 6660 tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt 6720 gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca agcgcgcaat 6780 taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc ttatgcaata 6840 ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca aggagagaaa 6900 aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt attaggaagg 6960 caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg cagagatatt 7020 gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca gatctgagcc 7080 tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga 7140 gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaga 7200 cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac ttgaaagcga 7260 aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg cgcacggcaa 7320 gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga ggctagaagg 7380 agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg cgatgggaaa 7440 aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata gtatgggcaa 7500 gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca gaaggctgta 7560 gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa cttagatcat 7620 tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata aaagacacca 7680 aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc gcacagcaag 7740 cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag aagtgaatta 7800 tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa ggcaaagaga 7860 agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct tgggttcttg 7920 ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca ggccagacaa 7980 ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga ggcgcaacag 8040 catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat cctggctgtg 8100 gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg aaaactcatt 8160 tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga acagatttgg 8220 aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag cttaatacac 8280 tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt attggaatta 8340 gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg gtatataaaa 8400 ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc tgtactttct 8460 atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca cctcccaacc 8520 ccgaggggac ccttgcgcct tttccaaggc agccctgggt ttgcgcaggg acgcggctgc 8580 tctgggcgtg gttccgggaa acgcagcggc gccgaccctg ggtctcgcac attcttcacg 8640 tccgttcgca gcgtcacccg gatcttcgcc gctacccttg tgggcccccc ggcgacgctt 8700 cctgctccgc ccctaagtcg ggaaggttcc ttgcggttcg cggcgtgccg gacgtgacaa 8760 acggaagccg cacgtctcac tagtaccctc gcagacggac agcgccaggg agcaatggca 8820 gcgcgccgac cgcgatgggc tgtggccaat agcggctgct cagcagggcg cgccgagagc 8880 agcggccggg aaggggcggt gcgggaggcg gggtgtgggg cggtagtgtg ggccctgttc 8940 ctgcccgcgc ggtgttccgc attctgcaag cctccggagc gcacgtcggc agtcggctcc 9000 ctcgttgacc gaatcaccga cctctctccc cagggggtac ccagctgtct agagaattct 9060 agatcttgag acaaatggca gtattcatcc acaattttaa aagaaaaggg gggattgggg 9120 ggtacagtgc aggggaaaga atagtagaca taatagcaac agacatacaa actaaagaat 9180 tacaaaaaca aattacaaaa attcaaaatt ttcgggttta ttacagggac agcagagatc 9240 cactttggcg ccggctcgag gggg 9264 <210> 153 <211> 204 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 153 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Thr Arg His Thr Val Asp Pro Asp Arg His Ile 35 40 45 Glu Arg Val Thr Glu Leu Gln Glu Leu Phe Leu Thr Arg Val Gly Leu 50 55 60 Asp Ile Gly Lys Val Trp Val Ala Asp Asp Gly Ala Ala Val Ala Val 65 70 75 80 Trp Thr Thr Pro Glu Ser Val Glu Ala Gly Ala Val Phe Ala Glu Ile 85 90 95 Gly Pro Arg Met Ala Glu Leu Ser Gly Ser Arg Leu Ala Ala Gln Gln 100 105 110 Gln Met Glu Gly Leu Leu Ala Pro His Arg Pro Lys Glu Pro Ala Trp 115 120 125 Phe Leu Ala Thr Val Gly Val Ser Pro Asp His Gln Gly Lys Gly Leu 130 135 140 Gly Ser Ala Val Val Leu Pro Gly Val Glu Ala Ala Glu Arg Ala Gly 145 150 155 160 Val Pro Ala Phe Leu Glu Thr Ser Ala Pro Arg Asn Leu Pro Phe Tyr 165 170 175 Glu Arg Leu Gly Phe Thr Val Thr Ala Asp Val Glu Val Pro Glu Gly 180 185 190 Pro Arg Thr Trp Cys Met Thr Arg Lys Pro Gly Ala 195 200 <210> 154 <211> 9204 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 154 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaccgagta caagcccacg 660 gtgcgcctcg ccacccgcga cgacgtcccc agggccgtac gcaccctcgc cgccgcgttc 720 gccgactacc ccgccacgcg ccacaccgtc gatccggacc gccacatcga gcgggtcacc 780 gagctgcaag aactcttcct cacgcgcgtc gggctcgaca tcggcaaggt gtgggtcgcg 840 gacgacggcg ccgcggtggc ggtctggacc acgccggaga gcgtcgaagc gtgcctttca 900 tacgagaccg agatcctgac tgtcgagtac ggattgcttc ctatcggcaa aatcgtggag 960 aagaggattg aatgtaccgt ctattcagtc gataataatg ggaacatcta cacacagccc 1020 gtggctcaat ggcacgacag aggagagcag gaagtttttg aatactgtct cgaggacgga 1080 tccctcatcc gcgctactaa agatcataag tttatgaccg tggacggcca gatgctgcca 1140 attgacgaaa tttttgaacg agagctggat ctgatgagag tcgacaacct tccaaactga 1200 ttaattaaga attcgaccca gctttcttgt acaaagtggt tggtaagcct atccctaacc 1260 ctctcctcgg tctcgattct acgtagtaat gagctagcag tctcgaggtt aacgaattcc 1320 gccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt gcgcttgtct 1380 atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc 1440 ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc 1500 tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg 1560 tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcccc tgcggccaaa 1620 agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt 1680 ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg 1740 atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta 1800 catgtgttta gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt 1860 tcctttgaaa aacacgataa taccatggcc atgagcgagc tgattaagga gaacatgcac 1920 atgaagctgt acatggaggg caccgtggac aaccatcact tcaagtgcac atccgagggc 1980 gaaggcaagc cctacgaggg cacccagacc atgagaatca aggtggtcga gggcggccct 2040 ctccccttcg ccttcgacat cctggctact agcttcctct acggcagcaa gaccttcatc 2100 aaccacaccc agggcatccc cgacttcttc aagcagtcct tccctgaggg cttcacatgg 2160 gagagagtca ccacatacga agacgggggc gtgctgaccg ctacccagga caccagcctc 2220 caggacggct gcctcatcta caacgtcaag atcagagggg tgaacttcac atccaacggc 2280 cctgtgatgc agaagaaaac actcggctgg gaggccttca ccgagacgct gtaccccgct 2340 gacggcggcc tggaaggcag aaacgacatg gccctgaagc tcgtgggcgg gagccatctg 2400 atcgcaaaca tcaagaccac atatagatcc aagaaacccg ctaagaacct caagatgcct 2460 ggcgtctact atgtggacta cagactggaa agaatcaagg aggccaacaa cgagacctac 2520 gtcgagcagc acgaggtggc agtggccaga tactgcgacc tccctagcaa actggggcac 2580 aagcttaatt aacaccggtg gcgcgttaag tcgacaatca acctctggat tacaaaattt 2640 gtgaaagatt gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg 2700 ctttaatgcc tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt 2760 ataaatcctg gttgctgtct ctttatgagg agttgtggcc cgttgtcagg caacgtggcg 2820 tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg gggcattgcc accacctgtc 2880 agctcctttc cgggactttc gctttccccc tccctattgc cacggcggaa ctcatcgccg 2940 cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt 3000 tgtcggggaa atcatcgtcc tttccttggc tgctcgcctg tgttgccacc tggattctgc 3060 gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg 3120 gcctgctgcc ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga 3180 tctccctttg ggccgcctcc ccgcgtcgac tttaagacca atgacttaca aggcagctgt 3240 agatcttagc cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaacg 3300 aagacaagat ctgctttttg cttgtactgg gtctctctgg ttagaccaga tctgagcctg 3360 ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt 3420 gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc 3480 cttttagtca gtgtggaaaa tctctagcag tacgtatagt agttcatgtc atcttattat 3540 tcagtattta taacttgcaa agaaatgaat atcagagagt gagaggaact tgtttattgc 3600 agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt 3660 ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggct 3720 ctagctatcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat 3780 tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc 3840 tctgagctat tccagaagta gtgaggaggc ttttttggag gcctagggac gtacccaatt 3900 cgccctatag tgagtcgtat tacgcgcgct cactggccgt cgttttacaa cgtcgtgact 3960 gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct 4020 ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg 4080 gcgaatggga cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca 4140 gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct 4200 ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt 4260 tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac 4320 gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct 4380 ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt 4440 ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac 4500 aaaaatttaa cgcgaatttt aacaaaatat taacgcttac aatttaggtg gcacttttcg 4560 gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc 4620 gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag 4680 tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt 4740 tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt 4800 gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga 4860 acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat 4920 tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga 4980 gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag 5040 tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg 5100 accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg 5160 ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt 5220 agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg 5280 gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc 5340 ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg 5400 tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac 5460 ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact 5520 gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa 5580 acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa 5640 aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg 5700 atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc 5760 gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac 5820 tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt agttaggcca 5880 ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt 5940 ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc 6000 ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg 6060 aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc 6120 cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac 6180 gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct 6240 ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc 6300 cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt 6360 tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac 6420 cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg 6480 cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca gctggcacga 6540 caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga gttagctcac 6600 tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt 6660 gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca agcgcgcaat 6720 taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc ttatgcaata 6780 ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca aggagagaaa 6840 aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt attaggaagg 6900 caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg cagagatatt 6960 gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca gatctgagcc 7020 tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga 7080 gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaga 7140 cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac ttgaaagcga 7200 aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg cgcacggcaa 7260 gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga ggctagaagg 7320 agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg cgatgggaaa 7380 aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata gtatgggcaa 7440 gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca gaaggctgta 7500 gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa cttagatcat 7560 tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata aaagacacca 7620 aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc gcacagcaag 7680 cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag aagtgaatta 7740 tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa ggcaaagaga 7800 agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct tgggttcttg 7860 ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca ggccagacaa 7920 ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga ggcgcaacag 7980 catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat cctggctgtg 8040 gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg aaaactcatt 8100 tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga acagatttgg 8160 aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag cttaatacac 8220 tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt attggaatta 8280 gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg gtatataaaa 8340 ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc tgtactttct 8400 atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca cctcccaacc 8460 ccgaggggac ccttgcgcct tttccaaggc agccctgggt ttgcgcaggg acgcggctgc 8520 tctgggcgtg gttccgggaa acgcagcggc gccgaccctg ggtctcgcac attcttcacg 8580 tccgttcgca gcgtcacccg gatcttcgcc gctacccttg tgggcccccc ggcgacgctt 8640 cctgctccgc ccctaagtcg ggaaggttcc ttgcggttcg cggcgtgccg gacgtgacaa 8700 acggaagccg cacgtctcac tagtaccctc gcagacggac agcgccaggg agcaatggca 8760 gcgcgccgac cgcgatgggc tgtggccaat agcggctgct cagcagggcg cgccgagagc 8820 agcggccggg aaggggcggt gcgggaggcg gggtgtgggg cggtagtgtg ggccctgttc 8880 ctgcccgcgc ggtgttccgc attctgcaag cctccggagc gcacgtcggc agtcggctcc 8940 ctcgttgacc gaatcaccga cctctctccc cagggggtac ccagctgtct agagaattct 9000 agatcttgag acaaatggca gtattcatcc acaattttaa aagaaaaggg gggattgggg 9060 ggtacagtgc aggggaaaga atagtagaca taatagcaac agacatacaa actaaagaat 9120 tacaaaaaca aattacaaaa attcaaaatt ttcgggttta ttacagggac agcagagatc 9180 cactttggcg ccggctcgag gggg 9204 <210> 155 <211> 186 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 155 Met Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp Asp Val 1 5 10 15 Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr Pro Ala 20 25 30 Thr Arg His Thr Val Asp Pro Asp Arg His Ile Glu Arg Val Thr Glu 35 40 45 Leu Gln Glu Leu Phe Leu Thr Arg Val Gly Leu Asp Ile Gly Lys Val 50 55 60 Trp Val Ala Asp Asp Gly Ala Ala Val Ala Val Trp Thr Thr Pro Glu 65 70 75 80 Ser Val Glu Ala Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu 85 90 95 Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys 100 105 110 Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val 115 120 125 Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu 130 135 140 Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr 145 150 155 160 Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu 165 170 175 Asp Leu Met Arg Val Asp Asn Leu Pro Asn 180 185 <210> 156 <211> 9108 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 156 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcggggcgg tgttcgccga gatcggcccg 780 cgcatggccg agttgagcgg ttcccggctg gccgcgcagc aacagatgga aggcctcctg 840 gcgccgcacc ggcccaagga gcccgcgtgg ttcctggcca ccgtcggcgt ctcgcccgac 900 caccagggca agggtctggg cagcgccgtc gtgctccccg gagtggaggc ggccgagcgc 960 gccggggtgc ccgccttcct ggagacctcc gcgccccgca acctcccctt ctacgagcgg 1020 ctcggcttca ccgtcaccgc cgacgtcgag gtgcccgaag gaccgcgcac ctggtgcatg 1080 acccgcaagc ccggtgcctg attaattaag aattcgaccc agctttcttg tacaaagtgg 1140 ttggtaagcc tatccctaac cctctcctcg gtctcgattc tacgtagtaa tgagctagca 1200 gtctcgaggt taacgaattc cgcccccccc ctaacgttac tggccgaagc cgcttggaat 1260 aaggccggtg tgcgcttgtc tatatgttat tttccaccat attgccgtct tttggcaatg 1320 tgagggcccg gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc 1380 tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt 1440 cttgaagaca aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg 1500 acaggtgccc ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac 1560 cccagtgcca cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg 1620 tattcaacaa ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg 1680 ggcctcggtg cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt ctaggccccc 1740 cgaaccacgg ggacgtggtt ttcctttgaa aaacacgata ataccatggt gagcaagggc 1800 gaggaggata acatggccat catcaaggag ttcatgcgct tcaaggtgca catggagggc 1860 tccgtgaacg gccacgagtt cgagatcgag ggcgagggcg agggccgccc ctacgagggc 1920 acccagaccg ccaagctgaa ggtgaccaag ggtggccccc tgcccttcgc ctgggacatc 1980 ctgtcccctc agttcatgta cggctccaag gcctacgtga agcaccccgc cgacatcccc 2040 gactacttga agctgtcctt ccccgagggc ttcaagtggg agcgcgtgat gaacttcgag 2100 gacggcggcg tggtgaccgt gacccaggac tcctccctgc aggacggcga gttcatctac 2160 aaggtgaagc tgcgcggcac caacttcccc tccgacggcc ccgtaatgca gaagaagacc 2220 atgggctggg aggcctcctc cgagcggatg taccccgagg acggcgccct gaagggcgag 2280 atcaagcaga ggctgaagct gaaggacggc ggccactacg acgctgaggt caagaccacc 2340 tacaaggcca agaagcccgt gcagctgccc ggcgcctaca acgtcaacat caagttggac 2400 atcacctccc acaacgagga ctacaccatc gtggaacagt acgaacgcgc cgagggccgc 2460 cactccaccg gcggcatgga cgagctgtac aagtaacacc ggtggcgcgt taagtcgaca 2520 atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc 2580 cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta 2640 tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt 2700 ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg 2760 gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta 2820 ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt 2880 tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg 2940 cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca 3000 atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc 3060 gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgcgt cgactttaag 3120 accaatgact tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact 3180 ggaagggcta attcactccc aacgaagaca agatctgctt tttgcttgta ctgggtctct 3240 ctggttagac cagatctgag cctgggagct ctctggctaa ctagggaacc cactgcttaa 3300 gcctcaataa agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc 3360 tggtaactag agatccctca gaccctttta gtcagtgtgg aaaatctcta gcagtacgta 3420 tagtagttca tgtcatctta ttattcagta tttataactt gcaaagaaat gaatatcaga 3480 gagtgagagg aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac 3540 aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat 3600 caatgtatct tatcatgtct ggctctagct atcccgcccc taactccgcc catcccgccc 3660 ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat 3720 gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg aggctttttt 3780 ggaggcctag ggacgtaccc aattcgccct atagtgagtc gtattacgcg cgctcactgg 3840 ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 3900 cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 3960 cccaacagtt gcgcagcctg aatggcgaat gggacgcgcc ctgtagcggc gcattaagcg 4020 cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg 4080 ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc 4140 taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa 4200 aacttgatta gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc 4260 ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac 4320 tcaaccctat ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt 4380 ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa atattaacgc 4440 ttacaattta ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt 4500 ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata 4560 atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt 4620 tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc 4680 tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat 4740 ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct 4800 atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc gccgcataca 4860 ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg 4920 catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa 4980 cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg 5040 ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga 5100 cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg 5160 cgaactactt actctagctt cccggcaaca attaatagac tggatggagg cggataaagt 5220 tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg 5280 agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc 5340 ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca 5400 gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc 5460 atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat 5520 cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc 5580 agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg 5640 ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct 5700 accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa atactgttct 5760 tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct 5820 cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg 5880 gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc 5940 gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga 6000 gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg 6060 cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta 6120 tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg 6180 ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg 6240 ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat 6300 taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc 6360 agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg cgcgttggcc 6420 gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa 6480 cgcaattaat gtgagttagc tcactcatta ggcaccccag gctttacact ttatgcttcc 6540 ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa acagctatga 6600 ccatgattac gccaagcgcg caattaaccc tcactaaagg gaacaaaagc tggagctgca 6660 agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag 6720 caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg 6780 tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact 6840 gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacat aaacgggtct 6900 ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt 6960 aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac 7020 tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc 7080 gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc 7140 ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa 7200 ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg 7260 ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata 7320 aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc 7380 tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga 7440 caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc 7500 aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca 7560 aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg 7620 agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga 7680 gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata 7740 ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg 7800 acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg 7860 ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag 7920 ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt 7980 tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt 8040 aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt 8100 aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag 8160 aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata 8220 acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta 8280 agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta 8340 tcgtttcaga cccacctccc aaccccgagg ggacccttgc gccttttcca aggcagccct 8400 gggtttgcgc agggacgcgg ctgctctggg cgtggttccg ggaaacgcag cggcgccgac 8460 cctgggtctc gcacattctt cacgtccgtt cgcagcgtca cccggatctt cgccgctacc 8520 cttgtgggcc ccccggcgac gcttcctgct ccgcccctaa gtcgggaagg ttccttgcgg 8580 ttcgcggcgt gccggacgtg acaaacggaa gccgcacgtc tcactagtac cctcgcagac 8640 ggacagcgcc agggagcaat ggcagcgcgc cgaccgcgat gggctgtggc caatagcggc 8700 tgctcagcag ggcgcgccga gagcagcggc cgggaagggg cggtgcggga ggcggggtgt 8760 ggggcggtag tgtgggccct gttcctgccc gcgcggtgtt ccgcattctg caagcctccg 8820 gagcgcacgt cggcagtcgg ctccctcgtt gaccgaatca ccgacctctc tccccagggg 8880 gtacccagct gtctagagaa ttctagatct tgagacaaat ggcagtattc atccacaatt 8940 ttaaaagaaa aggggggatt ggggggtaca gtgcagggga aagaatagta gacataatag 9000 caacagacat acaaactaaa gaattacaaa aacaaattac aaaaattcaa aattttcggg 9060 tttattacag ggacagcaga gatccacttt ggcgccggct cgaggggg 9108 <210> 157 <211> 152 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 157 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Gly Ala Val Phe Ala Glu Ile Gly Pro Arg Met 35 40 45 Ala Glu Leu Ser Gly Ser Arg Leu Ala Ala Gln Gln Gln Met Glu Gly 50 55 60 Leu Leu Ala Pro His Arg Pro Lys Glu Pro Ala Trp Phe Leu Ala Thr 65 70 75 80 Val Gly Val Ser Pro Asp His Gln Gly Lys Gly Leu Gly Ser Ala Val 85 90 95 Val Leu Pro Gly Val Glu Ala Ala Glu Arg Ala Gly Val Pro Ala Phe 100 105 110 Leu Glu Thr Ser Ala Pro Arg Asn Leu Pro Phe Tyr Glu Arg Leu Gly 115 120 125 Phe Thr Val Thr Ala Asp Val Glu Val Pro Glu Gly Pro Arg Thr Trp 130 135 140 Cys Met Thr Arg Lys Pro Gly Ala 145 150 <210> 158 <211> 9363 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 158 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaccgagta caagcccacg 660 gtgcgcctcg ccacccgcga cgacgtcccc agggccgtac gcaccctcgc cgccgcgttc 720 gccgactacc ccgccacgcg ccacaccgtc gatccggacc gccacatcga gcgggtcacc 780 gagctgcaag aactcttcct cacgcgcgtc gggctcgaca tcggcaaggt gtgggtcgcg 840 gacgacggcg ccgcggtggc ggtctggacc acgccggaga gcgtcgaagc gggggcggtg 900 ttcgccgaga tcggcccgcg catggccgag ttgagcggtt cccggctggc cgcgcagcaa 960 cagatggaag gcctcctggc gccgcaccgg cccaaggagc ccgcgtggtt cctggccacc 1020 gtcggcgtct cgcccgacca ccagggcaag tgcctttcat acgagaccga gatcctgact 1080 gtcgagtacg gattgcttcc tatcggcaaa atcgtggaga agaggattga atgtaccgtc 1140 tattcagtcg ataataatgg gaacatctac acacagcccg tggctcaatg gcacgacaga 1200 ggagagcagg aagtttttga atactgtctc gaggacggat ccctcatccg cgctactaaa 1260 gatcataagt ttatgaccgt ggacggccag atgctgccaa ttgacgaaat ttttgaacga 1320 gagctggatc tgatgagagt cgacaacctt ccaaactgat taattaagaa ttcgacccag 1380 ctttcttgta caaagtggtt ggtaagccta tccctaaccc tctcctcggt ctcgattcta 1440 cgtagtaatg agctagcagt ctcgaggtta acgaattccg ccccccccct aacgttactg 1500 gccgaagccg cttggaataa ggccggtgtg cgcttgtcta tatgttattt tccaccatat 1560 tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc 1620 ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag 1680 cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc 1740 ggaacccccc acctggcgac aggtgcccct gcggccaaaa gccacgtgta taagatacac 1800 ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca 1860 aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt 1920 gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa 1980 aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgataat 2040 accatggcca tgagcgagct gattaaggag aacatgcaca tgaagctgta catggagggc 2100 accgtggaca accatcactt caagtgcaca tccgagggcg aaggcaagcc ctacgagggc 2160 acccagacca tgagaatcaa ggtggtcgag ggcggccctc tccccttcgc cttcgacatc 2220 ctggctacta gcttcctcta cggcagcaag accttcatca accacaccca gggcatcccc 2280 gacttcttca agcagtcctt ccctgagggc ttcacatggg agagagtcac cacatacgaa 2340 gacgggggcg tgctgaccgc tacccaggac accagcctcc aggacggctg cctcatctac 2400 aacgtcaaga tcagaggggt gaacttcaca tccaacggcc ctgtgatgca gaagaaaaca 2460 ctcggctggg aggccttcac cgagacgctg taccccgctg acggcggcct ggaaggcaga 2520 aacgacatgg ccctgaagct cgtgggcggg agccatctga tcgcaaacat caagaccaca 2580 tatagatcca agaaacccgc taagaacctc aagatgcctg gcgtctacta tgtggactac 2640 agactggaaa gaatcaagga ggccaacaac gagacctacg tcgagcagca cgaggtggca 2700 gtggccagat actgcgacct ccctagcaaa ctggggcaca agcttaatta acaccggtgg 2760 cgcgttaagt cgacaatcaa cctctggatt acaaaatttg tgaaagattg actggtattc 2820 ttaactatgt tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg 2880 ctattgcttc ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc 2940 tttatgagga gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg 3000 acgcaacccc cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg 3060 ctttccccct ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga 3120 caggggctcg gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct 3180 ttccttggct gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg 3240 tcccttcggc cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc 3300 ctcttccgcg tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc 3360 cgcgtcgact ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa 3420 agaaaagggg ggactggaag ggctaattca ctcccaacga agacaagatc tgctttttgc 3480 ttgtactggg tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg 3540 gaacccactg cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg 3600 tctgttgtgt gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat 3660 ctctagcagt acgtatagta gttcatgtca tcttattatt cagtatttat aacttgcaaa 3720 gaaatgaata tcagagagtg agaggaactt gtttattgca gcttataatg gttacaaata 3780 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 3840 tttgtccaaa ctcatcaatg tatcttatca tgtctggctc tagctatccc gcccctaact 3900 ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta 3960 atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt ccagaagtag 4020 tgaggaggct tttttggagg cctagggacg tacccaattc gccctatagt gagtcgtatt 4080 acgcgcgctc actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc 4140 aacttaatcg ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc 4200 gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatgggac gcgccctgta 4260 gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca 4320 gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct 4380 ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc 4440 acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat 4500 agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc 4560 aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc 4620 cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta 4680 acaaaatatt aacgcttaca atttaggtgg cacttttcgg ggaaatgtgc gcggaacccc 4740 tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg 4800 ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc 4860 ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt 4920 gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct 4980 caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac 5040 ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact 5100 cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa 5160 gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga 5220 taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt 5280 tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga 5340 agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg 5400 caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat 5460 ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat 5520 tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc 5580 agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga 5640 tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc 5700 agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag 5760 gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc 5820 gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt 5880 tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt 5940 gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat 6000 accaaatact gttcttctag tgtagccgta gttaggccac cacttcaaga actctgtagc 6060 accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa 6120 gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg 6180 ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag 6240 atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag 6300 gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa 6360 cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt 6420 gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg 6480 gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc 6540 tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac 6600 cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct 6660 ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc 6720 gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt 6780 acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac 6840 aggaaacagc tatgaccatg attacgccaa gcgcgcaatt aaccctcact aaagggaaca 6900 aaagctggag ctgcaagctt aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg 6960 gtaacgatga gttagcaaca tgccttacaa ggagagaaaa agcaccgtgc atgccgattg 7020 gtggaagtaa ggtggtacga tcgtgcctta ttaggaaggc aacagacggg tctgacatgg 7080 attggacgaa ccactgaatt gccgcattgc agagatattg tatttaagtg cctagctcga 7140 tacataaacg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta 7200 gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc 7260 cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa 7320 atctctagca gtggcgcccg aacagggact tgaaagcgaa agggaaacca gaggagctct 7380 ctcgacgcag gactcggctt gctgaagcgc gcacggcaag aggcgagggg cggcgactgg 7440 tgagtacgcc aaaaattttg actagcggag gctagaagga gagagatggg tgcgagagcg 7500 tcagtattaa gcgggggaga attagatcgc gatgggaaaa aattcggtta aggccagggg 7560 gaaagaaaaa atataaatta aaacatatag tatgggcaag cagggagcta gaacgattcg 7620 cagttaatcc tggcctgtta gaaacatcag aaggctgtag acaaatactg ggacagctac 7680 aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca gtagcaaccc 7740 tctattgtgt gcatcaaagg atagagataa aagacaccaa ggaagcttta gacaagatag 7800 aggaagagca aaacaaaagt aagaccaccg cacagcaagc ggccgctgat cttcagacct 7860 ggaggaggag atatgaggga caattggaga agtgaattat ataaatataa agtagtaaaa 7920 attgaaccat taggagtagc acccaccaag gcaaagagaa gagtggtgca gagagaaaaa 7980 agagcagtgg gaataggagc tttgttcctt gggttcttgg gagcagcagg aagcactatg 8040 ggcgcagcgt caatgacgct gacggtacag gccagacaat tattgtctgg tatagtgcag 8100 cagcagaaca atttgctgag ggctattgag gcgcaacagc atctgttgca actcacagtc 8160 tggggcatca agcagctcca ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa 8220 cagctcctgg ggatttgggg ttgctctgga aaactcattt gcaccactgc tgtgccttgg 8280 aatgctagtt ggagtaataa atctctggaa cagatttgga atcacacgac ctggatggag 8340 tgggacagag aaattaacaa ttacacaagc ttaatacact ccttaattga agaatcgcaa 8400 aaccagcaag aaaagaatga acaagaatta ttggaattag ataaatgggc aagtttgtgg 8460 aattggttta acataacaaa ttggctgtgg tatataaaat tattcataat gatagtagga 8520 ggcttggtag gtttaagaat agtttttgct gtactttcta tagtgaatag agttaggcag 8580 ggatattcac cattatcgtt tcagacccac ctcccaaccc cgaggggacc cttgcgcctt 8640 ttccaaggca gccctgggtt tgcgcaggga cgcggctgct ctgggcgtgg ttccgggaaa 8700 cgcagcggcg ccgaccctgg gtctcgcaca ttcttcacgt ccgttcgcag cgtcacccgg 8760 atcttcgccg ctacccttgt gggccccccg gcgacgcttc ctgctccgcc cctaagtcgg 8820 gaaggttcct tgcggttcgc ggcgtgccgg acgtgacaaa cggaagccgc acgtctcact 8880 agtaccctcg cagacggaca gcgccaggga gcaatggcag cgcgccgacc gcgatgggct 8940 gtggccaata gcggctgctc agcagggcgc gccgagagca gcggccggga aggggcggtg 9000 cgggaggcgg ggtgtggggc ggtagtgtgg gccctgttcc tgcccgcgcg gtgttccgca 9060 ttctgcaagc ctccggagcg cacgtcggca gtcggctccc tcgttgaccg aatcaccgac 9120 ctctctcccc agggggtacc cagctgtcta gagaattcta gatcttgaga caaatggcag 9180 tattcatcca caattttaaa agaaaagggg ggattggggg gtacagtgca ggggaaagaa 9240 tagtagacat aatagcaaca gacatacaaa ctaaagaatt acaaaaacaa attacaaaaa 9300 ttcaaaattt tcgggtttat tacagggaca gcagagatcc actttggcgc cggctcgagg 9360 ggg 9363 <210> 159 <211> 239 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 159 Met Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp Asp Val 1 5 10 15 Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr Pro Ala 20 25 30 Thr Arg His Thr Val Asp Pro Asp Arg His Ile Glu Arg Val Thr Glu 35 40 45 Leu Gln Glu Leu Phe Leu Thr Arg Val Gly Leu Asp Ile Gly Lys Val 50 55 60 Trp Val Ala Asp Asp Gly Ala Ala Val Ala Val Trp Thr Thr Pro Glu 65 70 75 80 Ser Val Glu Ala Gly Ala Val Phe Ala Glu Ile Gly Pro Arg Met Ala 85 90 95 Glu Leu Ser Gly Ser Arg Leu Ala Ala Gln Gln Gln Met Glu Gly Leu 100 105 110 Leu Ala Pro His Arg Pro Lys Glu Pro Ala Trp Phe Leu Ala Thr Val 115 120 125 Gly Val Ser Pro Asp His Gln Gly Lys Cys Leu Ser Tyr Glu Thr Glu 130 135 140 Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu 145 150 155 160 Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile 165 170 175 Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val 180 185 190 Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp 195 200 205 His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile 210 215 220 Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn 225 230 235 <210> 160 <211> 8949 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 160 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcggtctgg gcagcgccgt cgtgctcccc 780 ggagtggagg cggccgagcg cgccggggtg cccgccttcc tggagacctc cgcgccccgc 840 aacctcccct tctacgagcg gctcggcttc accgtcaccg ccgacgtcga ggtgcccgaa 900 ggaccgcgca cctggtgcat gacccgcaag cccggtgcct gattaattaa gaattcgacc 960 cagctttctt gtacaaagtg gttggtaagc ctatccctaa ccctctcctc ggtctcgatt 1020 ctacgtagta atgagctagc agtctcgagg ttaacgaatt ccgccccccc cctaacgtta 1080 ctggccgaag ccgcttggaa taaggccggt gtgcgcttgt ctatatgtta ttttccacca 1140 tattgccgtc ttttggcaat gtgagggccc ggaaacctgg ccctgtcttc ttgacgagca 1200 ttcctagggg tctttcccct ctcgccaaag gaatgcaagg tctgttgaat gtcgtgaagg 1260 aagcagttcc tctggaagct tcttgaagac aaacaacgtc tgtagcgacc ctttgcaggc 1320 agcggaaccc cccacctggc gacaggtgcc cctgcggcca aaagccacgt gtataagata 1380 cacctgcaaa ggcggcacaa ccccagtgcc acgttgtgag ttggatagtt gtggaaagag 1440 tcaaatggct ctcctcaagc gtattcaaca aggggctgaa ggatgcccag aaggtacccc 1500 attgtatggg atctgatctg gggcctcggt gcacatgctt tacatgtgtt tagtcgaggt 1560 taaaaaaacg tctaggcccc ccgaaccacg gggacgtggt tttcctttga aaaacacgat 1620 aataccatgg tgagcaaggg cgaggaggat aacatggcca tcatcaagga gttcatgcgc 1680 ttcaaggtgc acatggaggg ctccgtgaac ggccacgagt tcgagatcga gggcgagggc 1740 gagggccgcc cctacgaggg cacccagacc gccaagctga aggtgaccaa gggtggcccc 1800 ctgcccttcg cctgggacat cctgtcccct cagttcatgt acggctccaa ggcctacgtg 1860 aagcaccccg ccgacatccc cgactacttg aagctgtcct tccccgaggg cttcaagtgg 1920 gagcgcgtga tgaacttcga ggacggcggc gtggtgaccg tgacccagga ctcctccctg 1980 caggacggcg agttcatcta caaggtgaag ctgcgcggca ccaacttccc ctccgacggc 2040 cccgtaatgc agaagaagac catgggctgg gaggcctcct ccgagcggat gtaccccgag 2100 gacggcgccc tgaagggcga gatcaagcag aggctgaagc tgaaggacgg cggccactac 2160 gacgctgagg tcaagaccac ctacaaggcc aagaagcccg tgcagctgcc cggcgcctac 2220 aacgtcaaca tcaagttgga catcacctcc cacaacgagg actacaccat cgtggaacag 2280 tacgaacgcg ccgagggccg ccactccacc ggcggcatgg acgagctgta caagtaacac 2340 cggtggcgcg ttaagtcgac aatcaacctc tggattacaa aatttgtgaa agattgactg 2400 gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt 2460 atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc 2520 tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt 2580 ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga 2640 ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct 2700 gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat 2760 cgtcctttcc ttggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct 2820 gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc 2880 tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg 2940 cctccccgcg tcgactttaa gaccaatgac ttacaaggca gctgtagatc ttagccactt 3000 tttaaaagaa aaggggggac tggaagggct aattcactcc caacgaagac aagatctgct 3060 ttttgcttgt actgggtctc tctggttaga ccagatctga gcctgggagc tctctggcta 3120 actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc aagtagtgtg 3180 tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt agtcagtgtg 3240 gaaaatctct agcagtacgt atagtagttc atgtcatctt attattcagt atttataact 3300 tgcaaagaaa tgaatatcag agagtgagag gaacttgttt attgcagctt ataatggtta 3360 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 3420 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggctctagc tatcccgccc 3480 ctaactccgc ccatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc 3540 tgactaattt tttttattta tgcagaggcc gaggccgcct cggcctctga gctattccag 3600 aagtagtgag gaggcttttt tggaggccta gggacgtacc caattcgccc tatagtgagt 3660 cgtattacgc gcgctcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg 3720 ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag 3780 aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgggacgcgc 3840 cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac 3900 ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg 3960 ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt 4020 tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc 4080 cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct 4140 tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga 4200 ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga 4260 attttaacaa aatattaacg cttacaattt aggtggcact tttcggggaa atgtgcgcgg 4320 aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata 4380 accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg 4440 tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac 4500 gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact 4560 ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat 4620 gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga 4680 gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac 4740 agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat 4800 gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac 4860 cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct 4920 gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac 4980 gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga 5040 ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg 5100 gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact 5160 ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac 5220 tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta 5280 actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt 5340 taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga 5400 gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc 5460 tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt 5520 ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc 5580 gcagatacca aatactgttc ttctagtgta gccgtagtta ggccaccact tcaagaactc 5640 tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg 5700 cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg 5760 gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga 5820 actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc 5880 ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg 5940 gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg 6000 atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt 6060 tttacggttc ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc 6120 tgattctgtg gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg 6180 aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc 6240 gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt ttcccgactg 6300 gaaagcgggc agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca 6360 ggctttacac tttatgcttc cggctcgtat gttgtgtgga attgtgagcg gataacaatt 6420 tcacacagga aacagctatg accatgatta cgccaagcgc gcaattaacc ctcactaaag 6480 ggaacaaaag ctggagctgc aagcttaatg tagtcttatg caatactctt gtagtcttgc 6540 aacatggtaa cgatgagtta gcaacatgcc ttacaaggag agaaaaagca ccgtgcatgc 6600 cgattggtgg aagtaaggtg gtacgatcgt gccttattag gaaggcaaca gacgggtctg 6660 acatggattg gacgaaccac tgaattgccg cattgcagag atattgtatt taagtgccta 6720 gctcgataca taaacgggtc tctctggtta gaccagatct gagcctggga gctctctggc 6780 taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg 6840 tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg 6900 tggaaaatct ctagcagtgg cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg 6960 agctctctcg acgcaggact cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc 7020 gactggtgag tacgccaaaa attttgacta gcggaggcta gaaggagaga gatgggtgcg 7080 agagcgtcag tattaagcgg gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc 7140 cagggggaaa gaaaaaatat aaattaaaac atatagtatg ggcaagcagg gagctagaac 7200 gattcgcagt taatcctggc ctgttagaaa catcagaagg ctgtagacaa atactgggac 7260 agctacaacc atcccttcag acaggatcag aagaacttag atcattatat aatacagtag 7320 caaccctcta ttgtgtgcat caaaggatag agataaaaga caccaaggaa gctttagaca 7380 agatagagga agagcaaaac aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc 7440 agacctggag gaggagatat gagggacaat tggagaagtg aattatataa atataaagta 7500 gtaaaaattg aaccattagg agtagcaccc accaaggcaa agagaagagt ggtgcagaga 7560 gaaaaaagag cagtgggaat aggagctttg ttccttgggt tcttgggagc agcaggaagc 7620 actatgggcg cagcgtcaat gacgctgacg gtacaggcca gacaattatt gtctggtata 7680 gtgcagcagc agaacaattt gctgagggct attgaggcgc aacagcatct gttgcaactc 7740 acagtctggg gcatcaagca gctccaggca agaatcctgg ctgtggaaag atacctaaag 7800 gatcaacagc tcctggggat ttggggttgc tctggaaaac tcatttgcac cactgctgtg 7860 ccttggaatg ctagttggag taataaatct ctggaacaga tttggaatca cacgacctgg 7920 atggagtggg acagagaaat taacaattac acaagcttaa tacactcctt aattgaagaa 7980 tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg aattagataa atgggcaagt 8040 ttgtggaatt ggtttaacat aacaaattgg ctgtggtata taaaattatt cataatgata 8100 gtaggaggct tggtaggttt aagaatagtt tttgctgtac tttctatagt gaatagagtt 8160 aggcagggat attcaccatt atcgtttcag acccacctcc caaccccgag gggacccttg 8220 cgccttttcc aaggcagccc tgggtttgcg cagggacgcg gctgctctgg gcgtggttcc 8280 gggaaacgca gcggcgccga ccctgggtct cgcacattct tcacgtccgt tcgcagcgtc 8340 acccggatct tcgccgctac ccttgtgggc cccccggcga cgcttcctgc tccgccccta 8400 agtcgggaag gttccttgcg gttcgcggcg tgccggacgt gacaaacgga agccgcacgt 8460 ctcactagta ccctcgcaga cggacagcgc cagggagcaa tggcagcgcg ccgaccgcga 8520 tgggctgtgg ccaatagcgg ctgctcagca gggcgcgccg agagcagcgg ccgggaaggg 8580 gcggtgcggg aggcggggtg tggggcggta gtgtgggccc tgttcctgcc cgcgcggtgt 8640 tccgcattct gcaagcctcc ggagcgcacg tcggcagtcg gctccctcgt tgaccgaatc 8700 accgacctct ctccccaggg ggtacccagc tgtctagaga attctagatc ttgagacaaa 8760 tggcagtatt catccacaat tttaaaagaa aaggggggat tggggggtac agtgcagggg 8820 aaagaatagt agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta 8880 caaaaattca aaattttcgg gtttattaca gggacagcag agatccactt tggcgccggc 8940 tcgaggggg 8949 <210> 161 <211> 99 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 161 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Gly Leu Gly Ser Ala Val Val Leu Pro Gly Val 35 40 45 Glu Ala Ala Glu Arg Ala Gly Val Pro Ala Phe Leu Glu Thr Ser Ala 50 55 60 Pro Arg Asn Leu Pro Phe Tyr Glu Arg Leu Gly Phe Thr Val Thr Ala 65 70 75 80 Asp Val Glu Val Pro Glu Gly Pro Arg Thr Trp Cys Met Thr Arg Lys 85 90 95 Pro Gly Ala <210> 162 <211> 9426 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 162 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaccgagta caagcccacg 660 gtgcgcctcg ccacccgcga cgacgtcccc agggccgtac gcaccctcgc cgccgcgttc 720 gccgactacc ccgccacgcg ccacaccgtc gatccggacc gccacatcga gcgggtcacc 780 gagctgcaag aactcttcct cacgcgcgtc gggctcgaca tcggcaaggt gtgggtcgcg 840 gacgacggcg ccgcggtggc ggtctggacc acgccggaga gcgtcgaagc gggggcggtg 900 ttcgccgaga tcggcccgcg catggccgag ttgagcggtt cccggctggc cgcgcagcaa 960 cagatggaag gcctcctggc gccgcaccgg cccaaggagc ccgcgtggtt cctggccacc 1020 gtcggcgtct cgcccgacca ccagggcaag ggtctgggca gcgccgtcgt gctccccgga 1080 gtggaggcgg ccgagcgcgc cggggtgccc gcctgccttt catacgagac cgagatcctg 1140 actgtcgagt acggattgct tcctatcggc aaaatcgtgg agaagaggat tgaatgtacc 1200 gtctattcag tcgataataa tgggaacatc tacacacagc ccgtggctca atggcacgac 1260 agaggagagc aggaagtttt tgaatactgt ctcgaggacg gatccctcat ccgcgctact 1320 aaagatcata agtttatgac cgtggacggc cagatgctgc caattgacga aatttttgaa 1380 cgagagctgg atctgatgag agtcgacaac cttccaaact gattaattaa gaattcgacc 1440 cagctttctt gtacaaagtg gttggtaagc ctatccctaa ccctctcctc ggtctcgatt 1500 ctacgtagta atgagctagc agtctcgagg ttaacgaatt ccgccccccc cctaacgtta 1560 ctggccgaag ccgcttggaa taaggccggt gtgcgcttgt ctatatgtta ttttccacca 1620 tattgccgtc ttttggcaat gtgagggccc ggaaacctgg ccctgtcttc ttgacgagca 1680 ttcctagggg tctttcccct ctcgccaaag gaatgcaagg tctgttgaat gtcgtgaagg 1740 aagcagttcc tctggaagct tcttgaagac aaacaacgtc tgtagcgacc ctttgcaggc 1800 agcggaaccc cccacctggc gacaggtgcc cctgcggcca aaagccacgt gtataagata 1860 cacctgcaaa ggcggcacaa ccccagtgcc acgttgtgag ttggatagtt gtggaaagag 1920 tcaaatggct ctcctcaagc gtattcaaca aggggctgaa ggatgcccag aaggtacccc 1980 attgtatggg atctgatctg gggcctcggt gcacatgctt tacatgtgtt tagtcgaggt 2040 taaaaaaacg tctaggcccc ccgaaccacg gggacgtggt tttcctttga aaaacacgat 2100 aataccatgg ccatgagcga gctgattaag gagaacatgc acatgaagct gtacatggag 2160 ggcaccgtgg acaaccatca cttcaagtgc acatccgagg gcgaaggcaa gccctacgag 2220 ggcacccaga ccatgagaat caaggtggtc gagggcggcc ctctcccctt cgccttcgac 2280 atcctggcta ctagcttcct ctacggcagc aagaccttca tcaaccacac ccagggcatc 2340 cccgacttct tcaagcagtc cttccctgag ggcttcacat gggagagagt caccacatac 2400 gaagacgggg gcgtgctgac cgctacccag gacaccagcc tccaggacgg ctgcctcatc 2460 tacaacgtca agatcagagg ggtgaacttc acatccaacg gccctgtgat gcagaagaaa 2520 acactcggct gggaggcctt caccgagacg ctgtaccccg ctgacggcgg cctggaaggc 2580 agaaacgaca tggccctgaa gctcgtgggc gggagccatc tgatcgcaaa catcaagacc 2640 acatatagat ccaagaaacc cgctaagaac ctcaagatgc ctggcgtcta ctatgtggac 2700 tacagactgg aaagaatcaa ggaggccaac aacgagacct acgtcgagca gcacgaggtg 2760 gcagtggcca gatactgcga cctccctagc aaactggggc acaagcttaa ttaacaccgg 2820 tggcgcgtta agtcgacaat caacctctgg attacaaaat ttgtgaaaga ttgactggta 2880 ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc 2940 atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt 3000 ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg 3060 ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt 3120 tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct 3180 ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt 3240 cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct 3300 acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc 3360 ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct 3420 ccccgcgtcg actttaagac caatgactta caaggcagct gtagatctta gccacttttt 3480 aaaagaaaag gggggactgg aagggctaat tcactcccaa cgaagacaag atctgctttt 3540 tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact 3600 agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc 3660 ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa 3720 aatctctagc agtacgtata gtagttcatg tcatcttatt attcagtatt tataacttgc 3780 aaagaaatga atatcagaga gtgagaggaa cttgtttatt gcagcttata atggttacaa 3840 ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg 3900 tggtttgtcc aaactcatca atgtatctta tcatgtctgg ctctagctat cccgccccta 3960 actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga 4020 ctaatttttt ttatttatgc agaggccgag gccgcctcgg cctctgagct attccagaag 4080 tagtgaggag gcttttttgg aggcctaggg acgtacccaa ttcgccctat agtgagtcgt 4140 attacgcgcg ctcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta 4200 cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg 4260 cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg gacgcgccct 4320 gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg 4380 ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg 4440 gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac 4500 ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct 4560 gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt 4620 tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta taagggattt 4680 tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt 4740 ttaacaaaat attaacgctt acaatttagg tggcactttt cggggaaatg tgcgcggaac 4800 ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc 4860 ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt 4920 cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct 4980 ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga 5040 tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag 5100 cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca 5160 actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga 5220 aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag 5280 tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc 5340 ttttttgcac aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa 5400 tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt 5460 gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg 5520 gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt 5580 tattgctgat aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg 5640 gccagatggt aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat 5700 ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact 5760 gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa 5820 aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt 5880 ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt 5940 ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg 6000 tttgccggat caagagctac caactctttt tccgaaggta actggcttca gcagagcgca 6060 gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca agaactctgt 6120 agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga 6180 taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc 6240 gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact 6300 gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga 6360 caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg 6420 aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt 6480 tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt 6540 acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga 6600 ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac 6660 gaccgagcgc agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc 6720 tctccccgcg cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa 6780 agcgggcagt gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc 6840 tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca 6900 cacaggaaac agctatgacc atgattacgc caagcgcgca attaaccctc actaaaggga 6960 acaaaagctg gagctgcaag cttaatgtag tcttatgcaa tactcttgta gtcttgcaac 7020 atggtaacga tgagttagca acatgcctta caaggagaga aaaagcaccg tgcatgccga 7080 ttggtggaag taaggtggta cgatcgtgcc ttattaggaa ggcaacagac gggtctgaca 7140 tggattggac gaaccactga attgccgcat tgcagagata ttgtatttaa gtgcctagct 7200 cgatacataa acgggtctct ctggttagac cagatctgag cctgggagct ctctggctaa 7260 ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca agtagtgtgt 7320 gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta gtcagtgtgg 7380 aaaatctcta gcagtggcgc ccgaacaggg acttgaaagc gaaagggaaa ccagaggagc 7440 tctctcgacg caggactcgg cttgctgaag cgcgcacggc aagaggcgag gggcggcgac 7500 tggtgagtac gccaaaaatt ttgactagcg gaggctagaa ggagagagat gggtgcgaga 7560 gcgtcagtat taagcggggg agaattagat cgcgatggga aaaaattcgg ttaaggccag 7620 ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag ctagaacgat 7680 tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata ctgggacagc 7740 tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat acagtagcaa 7800 ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct ttagacaaga 7860 tagaggaaga gcaaaacaaa agtaagacca ccgcacagca agcggccgct gatcttcaga 7920 cctggaggag gagatatgag ggacaattgg agaagtgaat tatataaata taaagtagta 7980 aaaattgaac cattaggagt agcacccacc aaggcaaaga gaagagtggt gcagagagaa 8040 aaaagagcag tgggaatagg agctttgttc cttgggttct tgggagcagc aggaagcact 8100 atgggcgcag cgtcaatgac gctgacggta caggccagac aattattgtc tggtatagtg 8160 cagcagcaga acaatttgct gagggctatt gaggcgcaac agcatctgtt gcaactcaca 8220 gtctggggca tcaagcagct ccaggcaaga atcctggctg tggaaagata cctaaaggat 8280 caacagctcc tggggatttg gggttgctct ggaaaactca tttgcaccac tgctgtgcct 8340 tggaatgcta gttggagtaa taaatctctg gaacagattt ggaatcacac gacctggatg 8400 gagtgggaca gagaaattaa caattacaca agcttaatac actccttaat tgaagaatcg 8460 caaaaccagc aagaaaagaa tgaacaagaa ttattggaat tagataaatg ggcaagtttg 8520 tggaattggt ttaacataac aaattggctg tggtatataa aattattcat aatgatagta 8580 ggaggcttgg taggtttaag aatagttttt gctgtacttt ctatagtgaa tagagttagg 8640 cagggatatt caccattatc gtttcagacc cacctcccaa ccccgagggg acccttgcgc 8700 cttttccaag gcagccctgg gtttgcgcag ggacgcggct gctctgggcg tggttccggg 8760 aaacgcagcg gcgccgaccc tgggtctcgc acattcttca cgtccgttcg cagcgtcacc 8820 cggatcttcg ccgctaccct tgtgggcccc ccggcgacgc ttcctgctcc gcccctaagt 8880 cgggaaggtt ccttgcggtt cgcggcgtgc cggacgtgac aaacggaagc cgcacgtctc 8940 actagtaccc tcgcagacgg acagcgccag ggagcaatgg cagcgcgccg accgcgatgg 9000 gctgtggcca atagcggctg ctcagcaggg cgcgccgaga gcagcggccg ggaaggggcg 9060 gtgcgggagg cggggtgtgg ggcggtagtg tgggccctgt tcctgcccgc gcggtgttcc 9120 gcattctgca agcctccgga gcgcacgtcg gcagtcggct ccctcgttga ccgaatcacc 9180 gacctctctc cccagggggt acccagctgt ctagagaatt ctagatcttg agacaaatgg 9240 cagtattcat ccacaatttt aaaagaaaag gggggattgg ggggtacagt gcaggggaaa 9300 gaatagtaga cataatagca acagacatac aaactaaaga attacaaaaa caaattacaa 9360 aaattcaaaa ttttcgggtt tattacaggg acagcagaga tccactttgg cgccggctcg 9420 aggggg 9426 <210> 163 <211> 260 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 163 Met Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp Asp Val 1 5 10 15 Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr Pro Ala 20 25 30 Thr Arg His Thr Val Asp Pro Asp Arg His Ile Glu Arg Val Thr Glu 35 40 45 Leu Gln Glu Leu Phe Leu Thr Arg Val Gly Leu Asp Ile Gly Lys Val 50 55 60 Trp Val Ala Asp Asp Gly Ala Ala Val Ala Val Trp Thr Thr Pro Glu 65 70 75 80 Ser Val Glu Ala Gly Ala Val Phe Ala Glu Ile Gly Pro Arg Met Ala 85 90 95 Glu Leu Ser Gly Ser Arg Leu Ala Ala Gln Gln Gln Met Glu Gly Leu 100 105 110 Leu Ala Pro His Arg Pro Lys Glu Pro Ala Trp Phe Leu Ala Thr Val 115 120 125 Gly Val Ser Pro Asp His Gln Gly Lys Gly Leu Gly Ser Ala Val Val 130 135 140 Leu Pro Gly Val Glu Ala Ala Glu Arg Ala Gly Val Pro Ala Cys Leu 145 150 155 160 Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile 165 170 175 Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp 180 185 190 Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg 195 200 205 Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile 210 215 220 Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln Met Leu 225 230 235 240 Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp 245 250 255 Asn Leu Pro Asn 260 <210> 164 <211> 8886 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 164 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcttcctgg agacctccgc gccccgcaac 780 ctccccttct acgagcggct cggcttcacc gtcaccgccg acgtcgaggt gcccgaagga 840 ccgcgcacct ggtgcatgac ccgcaagccc ggtgcctgat taattaagaa ttcgacccag 900 ctttcttgta caaagtggtt ggtaagccta tccctaaccc tctcctcggt ctcgattcta 960 cgtagtaatg agctagcagt ctcgaggtta acgaattccg ccccccccct aacgttactg 1020 gccgaagccg cttggaataa ggccggtgtg cgcttgtcta tatgttattt tccaccatat 1080 tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc 1140 ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag 1200 cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc 1260 ggaacccccc acctggcgac aggtgcccct gcggccaaaa gccacgtgta taagatacac 1320 ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca 1380 aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt 1440 gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa 1500 aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgataat 1560 accatggtga gcaagggcga ggaggataac atggccatca tcaaggagtt catgcgcttc 1620 aaggtgcaca tggagggctc cgtgaacggc cacgagttcg agatcgaggg cgagggcgag 1680 ggccgcccct acgagggcac ccagaccgcc aagctgaagg tgaccaaggg tggccccctg 1740 cccttcgcct gggacatcct gtcccctcag ttcatgtacg gctccaaggc ctacgtgaag 1800 caccccgccg acatccccga ctacttgaag ctgtccttcc ccgagggctt caagtgggag 1860 cgcgtgatga acttcgagga cggcggcgtg gtgaccgtga cccaggactc ctccctgcag 1920 gacggcgagt tcatctacaa ggtgaagctg cgcggcacca acttcccctc cgacggcccc 1980 gtaatgcaga agaagaccat gggctgggag gcctcctccg agcggatgta ccccgaggac 2040 ggcgccctga agggcgagat caagcagagg ctgaagctga aggacggcgg ccactacgac 2100 gctgaggtca agaccaccta caaggccaag aagcccgtgc agctgcccgg cgcctacaac 2160 gtcaacatca agttggacat cacctcccac aacgaggact acaccatcgt ggaacagtac 2220 gaacgcgccg agggccgcca ctccaccggc ggcatggacg agctgtacaa gtaacaccgg 2280 tggcgcgtta agtcgacaat caacctctgg attacaaaat ttgtgaaaga ttgactggta 2340 ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc 2400 atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt 2460 ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg 2520 ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt 2580 tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct 2640 ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt 2700 cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct 2760 acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc 2820 ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct 2880 ccccgcgtcg actttaagac caatgactta caaggcagct gtagatctta gccacttttt 2940 aaaagaaaag gggggactgg aagggctaat tcactcccaa cgaagacaag atctgctttt 3000 tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact 3060 agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc 3120 ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa 3180 aatctctagc agtacgtata gtagttcatg tcatcttatt attcagtatt tataacttgc 3240 aaagaaatga atatcagaga gtgagaggaa cttgtttatt gcagcttata atggttacaa 3300 ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg 3360 tggtttgtcc aaactcatca atgtatctta tcatgtctgg ctctagctat cccgccccta 3420 actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga 3480 ctaatttttt ttatttatgc agaggccgag gccgcctcgg cctctgagct attccagaag 3540 tagtgaggag gcttttttgg aggcctaggg acgtacccaa ttcgccctat agtgagtcgt 3600 attacgcgcg ctcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta 3660 cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg 3720 cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg gacgcgccct 3780 gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg 3840 ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg 3900 gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac 3960 ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct 4020 gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt 4080 tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta taagggattt 4140 tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt 4200 ttaacaaaat attaacgctt acaatttagg tggcactttt cggggaaatg tgcgcggaac 4260 ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc 4320 ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt 4380 cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct 4440 ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga 4500 tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag 4560 cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca 4620 actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga 4680 aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag 4740 tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc 4800 ttttttgcac aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa 4860 tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt 4920 gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg 4980 gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt 5040 tattgctgat aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg 5100 gccagatggt aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat 5160 ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact 5220 gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa 5280 aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt 5340 ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt 5400 ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg 5460 tttgccggat caagagctac caactctttt tccgaaggta actggcttca gcagagcgca 5520 gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca agaactctgt 5580 agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga 5640 taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc 5700 gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact 5760 gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga 5820 caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg 5880 aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt 5940 tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt 6000 acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga 6060 ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac 6120 gaccgagcgc agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc 6180 tctccccgcg cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa 6240 agcgggcagt gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc 6300 tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca 6360 cacaggaaac agctatgacc atgattacgc caagcgcgca attaaccctc actaaaggga 6420 acaaaagctg gagctgcaag cttaatgtag tcttatgcaa tactcttgta gtcttgcaac 6480 atggtaacga tgagttagca acatgcctta caaggagaga aaaagcaccg tgcatgccga 6540 ttggtggaag taaggtggta cgatcgtgcc ttattaggaa ggcaacagac gggtctgaca 6600 tggattggac gaaccactga attgccgcat tgcagagata ttgtatttaa gtgcctagct 6660 cgatacataa acgggtctct ctggttagac cagatctgag cctgggagct ctctggctaa 6720 ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca agtagtgtgt 6780 gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta gtcagtgtgg 6840 aaaatctcta gcagtggcgc ccgaacaggg acttgaaagc gaaagggaaa ccagaggagc 6900 tctctcgacg caggactcgg cttgctgaag cgcgcacggc aagaggcgag gggcggcgac 6960 tggtgagtac gccaaaaatt ttgactagcg gaggctagaa ggagagagat gggtgcgaga 7020 gcgtcagtat taagcggggg agaattagat cgcgatggga aaaaattcgg ttaaggccag 7080 ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag ctagaacgat 7140 tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata ctgggacagc 7200 tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat acagtagcaa 7260 ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct ttagacaaga 7320 tagaggaaga gcaaaacaaa agtaagacca ccgcacagca agcggccgct gatcttcaga 7380 cctggaggag gagatatgag ggacaattgg agaagtgaat tatataaata taaagtagta 7440 aaaattgaac cattaggagt agcacccacc aaggcaaaga gaagagtggt gcagagagaa 7500 aaaagagcag tgggaatagg agctttgttc cttgggttct tgggagcagc aggaagcact 7560 atgggcgcag cgtcaatgac gctgacggta caggccagac aattattgtc tggtatagtg 7620 cagcagcaga acaatttgct gagggctatt gaggcgcaac agcatctgtt gcaactcaca 7680 gtctggggca tcaagcagct ccaggcaaga atcctggctg tggaaagata cctaaaggat 7740 caacagctcc tggggatttg gggttgctct ggaaaactca tttgcaccac tgctgtgcct 7800 tggaatgcta gttggagtaa taaatctctg gaacagattt ggaatcacac gacctggatg 7860 gagtgggaca gagaaattaa caattacaca agcttaatac actccttaat tgaagaatcg 7920 caaaaccagc aagaaaagaa tgaacaagaa ttattggaat tagataaatg ggcaagtttg 7980 tggaattggt ttaacataac aaattggctg tggtatataa aattattcat aatgatagta 8040 ggaggcttgg taggtttaag aatagttttt gctgtacttt ctatagtgaa tagagttagg 8100 cagggatatt caccattatc gtttcagacc cacctcccaa ccccgagggg acccttgcgc 8160 cttttccaag gcagccctgg gtttgcgcag ggacgcggct gctctgggcg tggttccggg 8220 aaacgcagcg gcgccgaccc tgggtctcgc acattcttca cgtccgttcg cagcgtcacc 8280 cggatcttcg ccgctaccct tgtgggcccc ccggcgacgc ttcctgctcc gcccctaagt 8340 cgggaaggtt ccttgcggtt cgcggcgtgc cggacgtgac aaacggaagc cgcacgtctc 8400 actagtaccc tcgcagacgg acagcgccag ggagcaatgg cagcgcgccg accgcgatgg 8460 gctgtggcca atagcggctg ctcagcaggg cgcgccgaga gcagcggccg ggaaggggcg 8520 gtgcgggagg cggggtgtgg ggcggtagtg tgggccctgt tcctgcccgc gcggtgttcc 8580 gcattctgca agcctccgga gcgcacgtcg gcagtcggct ccctcgttga ccgaatcacc 8640 gacctctctc cccagggggt acccagctgt ctagagaatt ctagatcttg agacaaatgg 8700 cagtattcat ccacaatttt aaaagaaaag gggggattgg ggggtacagt gcaggggaaa 8760 gaatagtaga cataatagca acagacatac aaactaaaga attacaaaaa caaattacaa 8820 aaattcaaaa ttttcgggtt tattacaggg acagcagaga tccactttgg cgccggctcg 8880 aggggg 8886 <210> 165 <211> 78 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 165 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Phe Leu Glu Thr Ser Ala Pro Arg Asn Leu Pro 35 40 45 Phe Tyr Glu Arg Leu Gly Phe Thr Val Thr Ala Asp Val Glu Val Pro 50 55 60 Glu Gly Pro Arg Thr Trp Cys Met Thr Arg Lys Pro Gly Ala 65 70 75 <210> 166 <211> 9492 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 166 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaccgagta caagcccacg 660 gtgcgcctcg ccacccgcga cgacgtcccc agggccgtac gcaccctcgc cgccgcgttc 720 gccgactacc ccgccacgcg ccacaccgtc gatccggacc gccacatcga gcgggtcacc 780 gagctgcaag aactcttcct cacgcgcgtc gggctcgaca tcggcaaggt gtgggtcgcg 840 gacgacggcg ccgcggtggc ggtctggacc acgccggaga gcgtcgaagc gggggcggtg 900 ttcgccgaga tcggcccgcg catggccgag ttgagcggtt cccggctggc cgcgcagcaa 960 cagatggaag gcctcctggc gccgcaccgg cccaaggagc ccgcgtggtt cctggccacc 1020 gtcggcgtct cgcccgacca ccagggcaag ggtctgggca gcgccgtcgt gctccccgga 1080 gtggaggcgg ccgagcgcgc cggggtgccc gccttcctgg agacctccgc gccccgcaac 1140 ctccccttct acgagcggct cggcttcacc gtcaccgcct gcctttcata cgagaccgag 1200 atcctgactg tcgagtacgg attgcttcct atcggcaaaa tcgtggagaa gaggattgaa 1260 tgtaccgtct attcagtcga taataatggg aacatctaca cacagcccgt ggctcaatgg 1320 cacgacagag gagagcagga agtttttgaa tactgtctcg aggacggatc cctcatccgc 1380 gctactaaag atcataagtt tatgaccgtg gacggccaga tgctgccaat tgacgaaatt 1440 tttgaacgag agctggatct gatgagagtc gacaaccttc caaactgatt aattaagaat 1500 tcgacccagc tttcttgtac aaagtggttg gtaagcctat ccctaaccct ctcctcggtc 1560 tcgattctac gtagtaatga gctagcagtc tcgaggttaa cgaattccgc ccccccccta 1620 acgttactgg ccgaagccgc ttggaataag gccggtgtgc gcttgtctat atgttatttt 1680 ccaccatatt gccgtctttt ggcaatgtga gggcccggaa acctggccct gtcttcttga 1740 cgagcattcc taggggtctt tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg 1800 tgaaggaagc agttcctctg gaagcttctt gaagacaaac aacgtctgta gcgacccttt 1860 gcaggcagcg gaacccccca cctggcgaca ggtgcccctg cggccaaaag ccacgtgtat 1920 aagatacacc tgcaaaggcg gcacaacccc agtgccacgt tgtgagttgg atagttgtgg 1980 aaagagtcaa atggctctcc tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg 2040 taccccattg tatgggatct gatctggggc ctcggtgcac atgctttaca tgtgtttagt 2100 cgaggttaaa aaaacgtcta ggccccccga accacgggga cgtggttttc ctttgaaaaa 2160 cacgataata ccatggccat gagcgagctg attaaggaga acatgcacat gaagctgtac 2220 atggagggca ccgtggacaa ccatcacttc aagtgcacat ccgagggcga aggcaagccc 2280 tacgagggca cccagaccat gagaatcaag gtggtcgagg gcggccctct ccccttcgcc 2340 ttcgacatcc tggctactag cttcctctac ggcagcaaga ccttcatcaa ccacacccag 2400 ggcatccccg acttcttcaa gcagtccttc cctgagggct tcacatggga gagagtcacc 2460 acatacgaag acgggggcgt gctgaccgct acccaggaca ccagcctcca ggacggctgc 2520 ctcatctaca acgtcaagat cagaggggtg aacttcacat ccaacggccc tgtgatgcag 2580 aagaaaacac tcggctggga ggccttcacc gagacgctgt accccgctga cggcggcctg 2640 gaaggcagaa acgacatggc cctgaagctc gtgggcggga gccatctgat cgcaaacatc 2700 aagaccacat atagatccaa gaaacccgct aagaacctca agatgcctgg cgtctactat 2760 gtggactaca gactggaaag aatcaaggag gccaacaacg agacctacgt cgagcagcac 2820 gaggtggcag tggccagata ctgcgacctc cctagcaaac tggggcacaa gcttaattaa 2880 caccggtggc gcgttaagtc gacaatcaac ctctggatta caaaatttgt gaaagattga 2940 ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt 3000 tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt 3060 tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg 3120 tgtttgctga cgcaaccccc actggttggg gcattgccac cacctgtcag ctcctttccg 3180 ggactttcgc tttccccctc cctattgcca cggcggaact catcgccgcc tgccttgccc 3240 gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgttg tcggggaaat 3300 catcgtcctt tccttggctg ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct 3360 tctgctacgt cccttcggcc ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg 3420 ctctgcggcc tcttccgcgt cttcgccttc gccctcagac gagtcggatc tccctttggg 3480 ccgcctcccc gcgtcgactt taagaccaat gacttacaag gcagctgtag atcttagcca 3540 ctttttaaaa gaaaaggggg gactggaagg gctaattcac tcccaacgaa gacaagatct 3600 gctttttgct tgtactgggt ctctctggtt agaccagatc tgagcctggg agctctctgg 3660 ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt 3720 gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct tttagtcagt 3780 gtggaaaatc tctagcagta cgtatagtag ttcatgtcat cttattattc agtatttata 3840 acttgcaaag aaatgaatat cagagagtga gaggaacttg tttattgcag cttataatgg 3900 ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc 3960 tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggctct agctatcccg 4020 cccctaactc cgcccatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat 4080 ggctgactaa ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc 4140 cagaagtagt gaggaggctt ttttggaggc ctagggacgt acccaattcg ccctatagtg 4200 agtcgtatta cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg 4260 gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg 4320 aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg 4380 cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta 4440 cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt 4500 tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg 4560 ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat 4620 cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac 4680 tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag 4740 ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg 4800 cgaattttaa caaaatatta acgcttacaa tttaggtggc acttttcggg gaaatgtgcg 4860 cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca 4920 ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt 4980 ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga 5040 aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga 5100 actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat 5160 gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca 5220 agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt 5280 cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac 5340 catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct 5400 aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga 5460 gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac 5520 aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat 5580 agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg 5640 ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc 5700 actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc 5760 aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg 5820 gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta 5880 atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg 5940 tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga 6000 tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt 6060 ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag 6120 agcgcagata ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa 6180 ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag 6240 tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca 6300 gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac 6360 cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa 6420 ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc 6480 agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg 6540 tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc 6600 ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc 6660 ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag 6720 ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa 6780 accgcctctc cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca ggtttcccga 6840 ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt tagctcactc attaggcacc 6900 ccaggcttta cactttatgc ttccggctcg tatgttgtgt ggaattgtga gcggataaca 6960 atttcacaca ggaaacagct atgaccatga ttacgccaag cgcgcaatta accctcacta 7020 aagggaacaa aagctggagc tgcaagctta atgtagtctt atgcaatact cttgtagtct 7080 tgcaacatgg taacgatgag ttagcaacat gccttacaag gagagaaaaa gcaccgtgca 7140 tgccgattgg tggaagtaag gtggtacgat cgtgccttat taggaaggca acagacgggt 7200 ctgacatgga ttggacgaac cactgaattg ccgcattgca gagatattgt atttaagtgc 7260 ctagctcgat acataaacgg gtctctctgg ttagaccaga tctgagcctg ggagctctct 7320 ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt gcttcaagta 7380 gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc cttttagtca 7440 gtgtggaaaa tctctagcag tggcgcccga acagggactt gaaagcgaaa gggaaaccag 7500 aggagctctc tcgacgcagg actcggcttg ctgaagcgcg cacggcaaga ggcgaggggc 7560 ggcgactggt gagtacgcca aaaattttga ctagcggagg ctagaaggag agagatgggt 7620 gcgagagcgt cagtattaag cgggggagaa ttagatcgcg atgggaaaaa attcggttaa 7680 ggccaggggg aaagaaaaaa tataaattaa aacatatagt atgggcaagc agggagctag 7740 aacgattcgc agttaatcct ggcctgttag aaacatcaga aggctgtaga caaatactgg 7800 gacagctaca accatccctt cagacaggat cagaagaact tagatcatta tataatacag 7860 tagcaaccct ctattgtgtg catcaaagga tagagataaa agacaccaag gaagctttag 7920 acaagataga ggaagagcaa aacaaaagta agaccaccgc acagcaagcg gccgctgatc 7980 ttcagacctg gaggaggaga tatgagggac aattggagaa gtgaattata taaatataaa 8040 gtagtaaaaa ttgaaccatt aggagtagca cccaccaagg caaagagaag agtggtgcag 8100 agagaaaaaa gagcagtggg aataggagct ttgttccttg ggttcttggg agcagcagga 8160 agcactatgg gcgcagcgtc aatgacgctg acggtacagg ccagacaatt attgtctggt 8220 atagtgcagc agcagaacaa tttgctgagg gctattgagg cgcaacagca tctgttgcaa 8280 ctcacagtct ggggcatcaa gcagctccag gcaagaatcc tggctgtgga aagataccta 8340 aaggatcaac agctcctggg gatttggggt tgctctggaa aactcatttg caccactgct 8400 gtgccttgga atgctagttg gagtaataaa tctctggaac agatttggaa tcacacgacc 8460 tggatggagt gggacagaga aattaacaat tacacaagct taatacactc cttaattgaa 8520 gaatcgcaaa accagcaaga aaagaatgaa caagaattat tggaattaga taaatgggca 8580 agtttgtgga attggtttaa cataacaaat tggctgtggt atataaaatt attcataatg 8640 atagtaggag gcttggtagg tttaagaata gtttttgctg tactttctat agtgaataga 8700 gttaggcagg gatattcacc attatcgttt cagacccacc tcccaacccc gaggggaccc 8760 ttgcgccttt tccaaggcag ccctgggttt gcgcagggac gcggctgctc tgggcgtggt 8820 tccgggaaac gcagcggcgc cgaccctggg tctcgcacat tcttcacgtc cgttcgcagc 8880 gtcacccgga tcttcgccgc tacccttgtg ggccccccgg cgacgcttcc tgctccgccc 8940 ctaagtcggg aaggttcctt gcggttcgcg gcgtgccgga cgtgacaaac ggaagccgca 9000 cgtctcacta gtaccctcgc agacggacag cgccagggag caatggcagc gcgccgaccg 9060 cgatgggctg tggccaatag cggctgctca gcagggcgcg ccgagagcag cggccgggaa 9120 ggggcggtgc gggaggcggg gtgtggggcg gtagtgtggg ccctgttcct gcccgcgcgg 9180 tgttccgcat tctgcaagcc tccggagcgc acgtcggcag tcggctccct cgttgaccga 9240 atcaccgacc tctctcccca gggggtaccc agctgtctag agaattctag atcttgagac 9300 aaatggcagt attcatccac aattttaaaa gaaaaggggg gattgggggg tacagtgcag 9360 gggaaagaat agtagacata atagcaacag acatacaaac taaagaatta caaaaacaaa 9420 ttacaaaaat tcaaaatttt cgggtttatt acagggacag cagagatcca ctttggcgcc 9480 ggctcgaggg gg 9492 <210> 167 <211> 282 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 167 Met Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp Asp Val 1 5 10 15 Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr Pro Ala 20 25 30 Thr Arg His Thr Val Asp Pro Asp Arg His Ile Glu Arg Val Thr Glu 35 40 45 Leu Gln Glu Leu Phe Leu Thr Arg Val Gly Leu Asp Ile Gly Lys Val 50 55 60 Trp Val Ala Asp Asp Gly Ala Ala Val Ala Val Trp Thr Thr Pro Glu 65 70 75 80 Ser Val Glu Ala Gly Ala Val Phe Ala Glu Ile Gly Pro Arg Met Ala 85 90 95 Glu Leu Ser Gly Ser Arg Leu Ala Ala Gln Gln Gln Met Glu Gly Leu 100 105 110 Leu Ala Pro His Arg Pro Lys Glu Pro Ala Trp Phe Leu Ala Thr Val 115 120 125 Gly Val Ser Pro Asp His Gln Gly Lys Gly Leu Gly Ser Ala Val Val 130 135 140 Leu Pro Gly Val Glu Ala Ala Glu Arg Ala Gly Val Pro Ala Phe Leu 145 150 155 160 Glu Thr Ser Ala Pro Arg Asn Leu Pro Phe Tyr Glu Arg Leu Gly Phe 165 170 175 Thr Val Thr Ala Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu 180 185 190 Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys 195 200 205 Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val 210 215 220 Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu 225 230 235 240 Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr 245 250 255 Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu 260 265 270 Asp Leu Met Arg Val Asp Asn Leu Pro Asn 275 280 <210> 168 <211> 8820 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 168 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcgacgtcg aggtgcccga aggaccgcgc 780 acctggtgca tgacccgcaa gcccggtgcc tgattaatta agaattcgac ccagctttct 840 tgtacaaagt ggttggtaag cctatcccta accctctcct cggtctcgat tctacgtagt 900 aatgagctag cagtctcgag gttaacgaat tccgcccccc ccctaacgtt actggccgaa 960 gccgcttgga ataaggccgg tgtgcgcttg tctatatgtt attttccacc atattgccgt 1020 cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg 1080 gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc 1140 ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc 1200 ccccacctgg cgacaggtgc ccctgcggcc aaaagccacg tgtataagat acacctgcaa 1260 aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc 1320 tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg 1380 gatctgatct ggggcctcgg tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaaac 1440 gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga taataccatg 1500 gtgagcaagg gcgaggagga taacatggcc atcatcaagg agttcatgcg cttcaaggtg 1560 cacatggagg gctccgtgaa cggccacgag ttcgagatcg agggcgaggg cgagggccgc 1620 ccctacgagg gcacccagac cgccaagctg aaggtgacca agggtggccc cctgcccttc 1680 gcctgggaca tcctgtcccc tcagttcatg tacggctcca aggcctacgt gaagcacccc 1740 gccgacatcc ccgactactt gaagctgtcc ttccccgagg gcttcaagtg ggagcgcgtg 1800 atgaacttcg aggacggcgg cgtggtgacc gtgacccagg actcctccct gcaggacggc 1860 gagttcatct acaaggtgaa gctgcgcggc accaacttcc cctccgacgg ccccgtaatg 1920 cagaagaaga ccatgggctg ggaggcctcc tccgagcgga tgtaccccga ggacggcgcc 1980 ctgaagggcg agatcaagca gaggctgaag ctgaaggacg gcggccacta cgacgctgag 2040 gtcaagacca cctacaaggc caagaagccc gtgcagctgc ccggcgccta caacgtcaac 2100 atcaagttgg acatcacctc ccacaacgag gactacacca tcgtggaaca gtacgaacgc 2160 gccgagggcc gccactccac cggcggcatg gacgagctgt acaagtaaca ccggtggcgc 2220 gttaagtcga caatcaacct ctggattaca aaatttgtga aagattgact ggtattctta 2280 actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta 2340 ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt 2400 atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg 2460 caacccccac tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt 2520 tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag 2580 gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaaatca tcgtcctttc 2640 cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc 2700 cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc 2760 ttccgcgtct tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc 2820 gtcgacttta agaccaatga cttacaaggc agctgtagat cttagccact ttttaaaaga 2880 aaagggggga ctggaagggc taattcactc ccaacgaaga caagatctgc tttttgcttg 2940 tactgggtct ctctggttag accagatctg agcctgggag ctctctggct aactagggaa 3000 cccactgctt aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct 3060 gttgtgtgac tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc 3120 tagcagtacg tatagtagtt catgtcatct tattattcag tatttataac ttgcaaagaa 3180 atgaatatca gagagtgaga ggaacttgtt tattgcagct tataatggtt acaaataaag 3240 caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt 3300 gtccaaactc atcaatgtat cttatcatgt ctggctctag ctatcccgcc cctaactccg 3360 cccatcccgc ccctaactcc gcccagttcc gcccattctc cgccccatgg ctgactaatt 3420 ttttttattt atgcagaggc cgaggccgcc tcggcctctg agctattcca gaagtagtga 3480 ggaggctttt ttggaggcct agggacgtac ccaattcgcc ctatagtgag tcgtattacg 3540 cgcgctcact ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac 3600 ttaatcgcct tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca 3660 ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atgggacgcg ccctgtagcg 3720 gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg 3780 ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc 3840 cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc 3900 tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga 3960 cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa 4020 ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg attttgccga 4080 tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattttaaca 4140 aaatattaac gcttacaatt taggtggcac ttttcgggga aatgtgcgcg gaacccctat 4200 ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata 4260 aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct 4320 tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa 4380 agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa 4440 cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt 4500 taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg 4560 tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca 4620 tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa 4680 cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt 4740 gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc 4800 cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa 4860 actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga 4920 ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc 4980 tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga 5040 tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga 5100 acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga 5160 ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat 5220 ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt 5280 ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct 5340 gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc 5400 ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc 5460 aaatactgtt cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc 5520 gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc 5580 gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg 5640 aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata 5700 cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta 5760 tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc 5820 ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg 5880 atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt 5940 cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt 6000 ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga 6060 gcgcagcgag tcagtgagcg aggaagcgga agagcgccca atacgcaaac cgcctctccc 6120 cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg tttcccgact ggaaagcggg 6180 cagtgagcgc aacgcaatta atgtgagtta gctcactcat taggcacccc aggctttaca 6240 ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc ggataacaat ttcacacagg 6300 aaacagctat gaccatgatt acgccaagcg cgcaattaac cctcactaaa gggaacaaaa 6360 gctggagctg caagcttaat gtagtcttat gcaatactct tgtagtcttg caacatggta 6420 acgatgagtt agcaacatgc cttacaagga gagaaaaagc accgtgcatg ccgattggtg 6480 gaagtaaggt ggtacgatcg tgccttatta ggaaggcaac agacgggtct gacatggatt 6540 ggacgaacca ctgaattgcc gcattgcaga gatattgtat ttaagtgcct agctcgatac 6600 ataaacgggt ctctctggtt agaccagatc tgagcctggg agctctctgg ctaactaggg 6660 aacccactgc ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt 6720 ctgttgtgtg actctggtaa ctagagatcc ctcagaccct tttagtcagt gtggaaaatc 6780 tctagcagtg gcgcccgaac agggacttga aagcgaaagg gaaaccagag gagctctctc 6840 gacgcaggac tcggcttgct gaagcgcgca cggcaagagg cgaggggcgg cgactggtga 6900 gtacgccaaa aattttgact agcggaggct agaaggagag agatgggtgc gagagcgtca 6960 gtattaagcg ggggagaatt agatcgcgat gggaaaaaat tcggttaagg ccagggggaa 7020 agaaaaaata taaattaaaa catatagtat gggcaagcag ggagctagaa cgattcgcag 7080 ttaatcctgg cctgttagaa acatcagaag gctgtagaca aatactggga cagctacaac 7140 catcccttca gacaggatca gaagaactta gatcattata taatacagta gcaaccctct 7200 attgtgtgca tcaaaggata gagataaaag acaccaagga agctttagac aagatagagg 7260 aagagcaaaa caaaagtaag accaccgcac agcaagcggc cgctgatctt cagacctgga 7320 ggaggagata tgagggacaa ttggagaagt gaattatata aatataaagt agtaaaaatt 7380 gaaccattag gagtagcacc caccaaggca aagagaagag tggtgcagag agaaaaaaga 7440 gcagtgggaa taggagcttt gttccttggg ttcttgggag cagcaggaag cactatgggc 7500 gcagcgtcaa tgacgctgac ggtacaggcc agacaattat tgtctggtat agtgcagcag 7560 cagaacaatt tgctgagggc tattgaggcg caacagcatc tgttgcaact cacagtctgg 7620 ggcatcaagc agctccaggc aagaatcctg gctgtggaaa gatacctaaa ggatcaacag 7680 ctcctgggga tttggggttg ctctggaaaa ctcatttgca ccactgctgt gccttggaat 7740 gctagttgga gtaataaatc tctggaacag atttggaatc acacgacctg gatggagtgg 7800 gacagagaaa ttaacaatta cacaagctta atacactcct taattgaaga atcgcaaaac 7860 cagcaagaaa agaatgaaca agaattattg gaattagata aatgggcaag tttgtggaat 7920 tggtttaaca taacaaattg gctgtggtat ataaaattat tcataatgat agtaggaggc 7980 ttggtaggtt taagaatagt ttttgctgta ctttctatag tgaatagagt taggcaggga 8040 tattcaccat tatcgtttca gacccacctc ccaaccccga ggggaccctt gcgccttttc 8100 caaggcagcc ctgggtttgc gcagggacgc ggctgctctg ggcgtggttc cgggaaacgc 8160 agcggcgccg accctgggtc tcgcacattc ttcacgtccg ttcgcagcgt cacccggatc 8220 ttcgccgcta cccttgtggg ccccccggcg acgcttcctg ctccgcccct aagtcgggaa 8280 ggttccttgc ggttcgcggc gtgccggacg tgacaaacgg aagccgcacg tctcactagt 8340 accctcgcag acggacagcg ccagggagca atggcagcgc gccgaccgcg atgggctgtg 8400 gccaatagcg gctgctcagc agggcgcgcc gagagcagcg gccgggaagg ggcggtgcgg 8460 gaggcggggt gtggggcggt agtgtgggcc ctgttcctgc ccgcgcggtg ttccgcattc 8520 tgcaagcctc cggagcgcac gtcggcagtc ggctccctcg ttgaccgaat caccgacctc 8580 tctccccagg gggtacccag ctgtctagag aattctagat cttgagacaa atggcagtat 8640 tcatccacaa ttttaaaaga aaagggggga ttggggggta cagtgcaggg gaaagaatag 8700 tagacataat agcaacagac atacaaacta aagaattaca aaaacaaatt acaaaaattc 8760 aaaattttcg ggtttattac agggacagca gagatccact ttggcgccgg ctcgaggggg 8820 <210> 169 <211> 56 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 169 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Asp Val Glu Val Pro Glu Gly Pro Arg Thr Trp 35 40 45 Cys Met Thr Arg Lys Pro Gly Ala 50 55 <210> 170 <211> 9129 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 170 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgaaaac atttaacatt 660 tctcaacagg atctagaatt agtagaagta gcgacagaga agattacaat gctttatgag 720 gataataaac atcatgtggg agcggcaatt cgtacgaaaa caggagaaat catttcggca 780 gtacatattg aagcgtatat aggacgagta actgtttgcc tttcatacga gaccgagatc 840 ctgactgtcg agtacggatt gcttcctatc ggcaaaatcg tggagaagag gattgaatgt 900 accgtctatt cagtcgataa taatgggaac atctacacac agcccgtggc tcaatggcac 960 gacagaggag agcaggaagt ttttgaatac tgtctcgagg acggatccct catccgcgct 1020 actaaagatc ataagtttat gaccgtggac ggccagatgc tgccaattga cgaaattttt 1080 gaacgagagc tggatctgat gagagtcgac aaccttccaa actgattaat taagaattcg 1140 acccagcttt cttgtacaaa gtggttggta agcctatccc taaccctctc ctcggtctcg 1200 attctacgta gtaatgagct agcagtctcg aggttaacga attccgcccc ccccctaacg 1260 ttactggccg aagccgcttg gaataaggcc ggtgtgcgct tgtctatatg ttattttcca 1320 ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga 1380 gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga 1440 aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca 1500 ggcagcggaa ccccccacct ggcgacaggt gcccctgcgg ccaaaagcca cgtgtataag 1560 atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa 1620 gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac 1680 cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga 1740 ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac 1800 gataatacca tggccatgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 1860 gagggcaccg tggacaacca tcacttcaag tgcacatccg agggcgaagg caagccctac 1920 gagggcaccc agaccatgag aatcaaggtg gtcgagggcg gccctctccc cttcgccttc 1980 gacatcctgg ctactagctt cctctacggc agcaagacct tcatcaacca cacccagggc 2040 atccccgact tcttcaagca gtccttccct gagggcttca catgggagag agtcaccaca 2100 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 2160 atctacaacg tcaagatcag aggggtgaac ttcacatcca acggccctgt gatgcagaag 2220 aaaacactcg gctgggaggc cttcaccgag acgctgtacc ccgctgacgg cggcctggaa 2280 ggcagaaacg acatggccct gaagctcgtg ggcgggagcc atctgatcgc aaacatcaag 2340 accacatata gatccaagaa acccgctaag aacctcaaga tgcctggcgt ctactatgtg 2400 gactacagac tggaaagaat caaggaggcc aacaacgaga cctacgtcga gcagcacgag 2460 gtggcagtgg ccagatactg cgacctccct agcaaactgg ggcacaagct taattaacac 2520 cggtggcgcg ttaagtcgac aatcaacctc tggattacaa aatttgtgaa agattgactg 2580 gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt 2640 atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc 2700 tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt 2760 ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga 2820 ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct 2880 gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat 2940 cgtcctttcc ttggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct 3000 gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc 3060 tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg 3120 cctccccgcg tcgactttaa gaccaatgac ttacaaggca gctgtagatc ttagccactt 3180 tttaaaagaa aaggggggac tggaagggct aattcactcc caacgaagac aagatctgct 3240 ttttgcttgt actgggtctc tctggttaga ccagatctga gcctgggagc tctctggcta 3300 actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc aagtagtgtg 3360 tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt agtcagtgtg 3420 gaaaatctct agcagtacgt atagtagttc atgtcatctt attattcagt atttataact 3480 tgcaaagaaa tgaatatcag agagtgagag gaacttgttt attgcagctt ataatggtta 3540 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 3600 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggctctagc tatcccgccc 3660 ctaactccgc ccatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc 3720 tgactaattt tttttattta tgcagaggcc gaggccgcct cggcctctga gctattccag 3780 aagtagtgag gaggcttttt tggaggccta gggacgtacc caattcgccc tatagtgagt 3840 cgtattacgc gcgctcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg 3900 ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag 3960 aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgggacgcgc 4020 cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac 4080 ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg 4140 ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt 4200 tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc 4260 cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct 4320 tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga 4380 ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga 4440 attttaacaa aatattaacg cttacaattt aggtggcact tttcggggaa atgtgcgcgg 4500 aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata 4560 accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg 4620 tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac 4680 gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact 4740 ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat 4800 gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga 4860 gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac 4920 agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat 4980 gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac 5040 cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct 5100 gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac 5160 gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga 5220 ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg 5280 gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact 5340 ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac 5400 tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta 5460 actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt 5520 taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga 5580 gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc 5640 tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt 5700 ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc 5760 gcagatacca aatactgttc ttctagtgta gccgtagtta ggccaccact tcaagaactc 5820 tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg 5880 cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg 5940 gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga 6000 actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc 6060 ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg 6120 gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg 6180 atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt 6240 tttacggttc ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc 6300 tgattctgtg gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg 6360 aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc 6420 gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt ttcccgactg 6480 gaaagcgggc agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca 6540 ggctttacac tttatgcttc cggctcgtat gttgtgtgga attgtgagcg gataacaatt 6600 tcacacagga aacagctatg accatgatta cgccaagcgc gcaattaacc ctcactaaag 6660 ggaacaaaag ctggagctgc aagcttaatg tagtcttatg caatactctt gtagtcttgc 6720 aacatggtaa cgatgagtta gcaacatgcc ttacaaggag agaaaaagca ccgtgcatgc 6780 cgattggtgg aagtaaggtg gtacgatcgt gccttattag gaaggcaaca gacgggtctg 6840 acatggattg gacgaaccac tgaattgccg cattgcagag atattgtatt taagtgccta 6900 gctcgataca taaacgggtc tctctggtta gaccagatct gagcctggga gctctctggc 6960 taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg 7020 tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg 7080 tggaaaatct ctagcagtgg cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg 7140 agctctctcg acgcaggact cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc 7200 gactggtgag tacgccaaaa attttgacta gcggaggcta gaaggagaga gatgggtgcg 7260 agagcgtcag tattaagcgg gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc 7320 cagggggaaa gaaaaaatat aaattaaaac atatagtatg ggcaagcagg gagctagaac 7380 gattcgcagt taatcctggc ctgttagaaa catcagaagg ctgtagacaa atactgggac 7440 agctacaacc atcccttcag acaggatcag aagaacttag atcattatat aatacagtag 7500 caaccctcta ttgtgtgcat caaaggatag agataaaaga caccaaggaa gctttagaca 7560 agatagagga agagcaaaac aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc 7620 agacctggag gaggagatat gagggacaat tggagaagtg aattatataa atataaagta 7680 gtaaaaattg aaccattagg agtagcaccc accaaggcaa agagaagagt ggtgcagaga 7740 gaaaaaagag cagtgggaat aggagctttg ttccttgggt tcttgggagc agcaggaagc 7800 actatgggcg cagcgtcaat gacgctgacg gtacaggcca gacaattatt gtctggtata 7860 gtgcagcagc agaacaattt gctgagggct attgaggcgc aacagcatct gttgcaactc 7920 acagtctggg gcatcaagca gctccaggca agaatcctgg ctgtggaaag atacctaaag 7980 gatcaacagc tcctggggat ttggggttgc tctggaaaac tcatttgcac cactgctgtg 8040 ccttggaatg ctagttggag taataaatct ctggaacaga tttggaatca cacgacctgg 8100 atggagtggg acagagaaat taacaattac acaagcttaa tacactcctt aattgaagaa 8160 tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg aattagataa atgggcaagt 8220 ttgtggaatt ggtttaacat aacaaattgg ctgtggtata taaaattatt cataatgata 8280 gtaggaggct tggtaggttt aagaatagtt tttgctgtac tttctatagt gaatagagtt 8340 aggcagggat attcaccatt atcgtttcag acccacctcc caaccccgag gggacccttg 8400 cgccttttcc aaggcagccc tgggtttgcg cagggacgcg gctgctctgg gcgtggttcc 8460 gggaaacgca gcggcgccga ccctgggtct cgcacattct tcacgtccgt tcgcagcgtc 8520 acccggatct tcgccgctac ccttgtgggc cccccggcga cgcttcctgc tccgccccta 8580 agtcgggaag gttccttgcg gttcgcggcg tgccggacgt gacaaacgga agccgcacgt 8640 ctcactagta ccctcgcaga cggacagcgc cagggagcaa tggcagcgcg ccgaccgcga 8700 tgggctgtgg ccaatagcgg ctgctcagca gggcgcgccg agagcagcgg ccgggaaggg 8760 gcggtgcggg aggcggggtg tggggcggta gtgtgggccc tgttcctgcc cgcgcggtgt 8820 tccgcattct gcaagcctcc ggagcgcacg tcggcagtcg gctccctcgt tgaccgaatc 8880 accgacctct ctccccaggg ggtacccagc tgtctagaga attctagatc ttgagacaaa 8940 tggcagtatt catccacaat tttaaaagaa aaggggggat tggggggtac agtgcagggg 9000 aaagaatagt agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta 9060 caaaaattca aaattttcgg gtttattaca gggacagcag agatccactt tggcgccggc 9120 tcgaggggg 9129 <210> 171 <211> 160 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 171 Met Lys Thr Phe Asn Ile Ser Gln Gln Asp Leu Glu Leu Val Glu Val 1 5 10 15 Ala Thr Glu Lys Ile Thr Met Leu Tyr Glu Asp Asn Lys His His Val 20 25 30 Gly Ala Ala Ile Arg Thr Lys Thr Gly Glu Ile Ile Ser Ala Val His 35 40 45 Ile Glu Ala Tyr Ile Gly Arg Val Thr Val Cys Leu Ser Tyr Glu Thr 50 55 60 Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val 65 70 75 80 Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn 85 90 95 Ile Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu 100 105 110 Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys 115 120 125 Asp His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu 130 135 140 Ile Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn 145 150 155 160 <210> 172 <211> 9006 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 172 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgtgcagaag ccattgcgat tggtagtgca 780 gtttcgaatg gacaaaagga ttttgacacg attgtagctg ttagacaccc ttattctgac 840 gaagtagata gaagtattcg agtggtaagt ccttgtggta tgtgtaggga gttgatttca 900 gactatgcac cagattgttt tgtgttaata gaaatgaatg gcaagttagt caaaactacg 960 attgaagaac tcattccact caaatatacc cgaaattaat taattaagaa ttcgacccag 1020 ctttcttgta caaagtggtt ggtaagccta tccctaaccc tctcctcggt ctcgattcta 1080 cgtagtaatg agctagcagt ctcgaggtta acgaattccg ccccccccct aacgttactg 1140 gccgaagccg cttggaataa ggccggtgtg cgcttgtcta tatgttattt tccaccatat 1200 tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc 1260 ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag 1320 cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc 1380 ggaacccccc acctggcgac aggtgcccct gcggccaaaa gccacgtgta taagatacac 1440 ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca 1500 aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt 1560 gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa 1620 aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgataat 1680 accatggtga gcaagggcga ggaggataac atggccatca tcaaggagtt catgcgcttc 1740 aaggtgcaca tggagggctc cgtgaacggc cacgagttcg agatcgaggg cgagggcgag 1800 ggccgcccct acgagggcac ccagaccgcc aagctgaagg tgaccaaggg tggccccctg 1860 cccttcgcct gggacatcct gtcccctcag ttcatgtacg gctccaaggc ctacgtgaag 1920 caccccgccg acatccccga ctacttgaag ctgtccttcc ccgagggctt caagtgggag 1980 cgcgtgatga acttcgagga cggcggcgtg gtgaccgtga cccaggactc ctccctgcag 2040 gacggcgagt tcatctacaa ggtgaagctg cgcggcacca acttcccctc cgacggcccc 2100 gtaatgcaga agaagaccat gggctgggag gcctcctccg agcggatgta ccccgaggac 2160 ggcgccctga agggcgagat caagcagagg ctgaagctga aggacggcgg ccactacgac 2220 gctgaggtca agaccaccta caaggccaag aagcccgtgc agctgcccgg cgcctacaac 2280 gtcaacatca agttggacat cacctcccac aacgaggact acaccatcgt ggaacagtac 2340 gaacgcgccg agggccgcca ctccaccggc ggcatggacg agctgtacaa gtaacaccgg 2400 tggcgcgtta agtcgacaat caacctctgg attacaaaat ttgtgaaaga ttgactggta 2460 ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc 2520 atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt 2580 ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg 2640 ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt 2700 tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct 2760 ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt 2820 cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct 2880 acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc 2940 ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct 3000 ccccgcgtcg actttaagac caatgactta caaggcagct gtagatctta gccacttttt 3060 aaaagaaaag gggggactgg aagggctaat tcactcccaa cgaagacaag atctgctttt 3120 tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact 3180 agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc 3240 ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa 3300 aatctctagc agtacgtata gtagttcatg tcatcttatt attcagtatt tataacttgc 3360 aaagaaatga atatcagaga gtgagaggaa cttgtttatt gcagcttata atggttacaa 3420 ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg 3480 tggtttgtcc aaactcatca atgtatctta tcatgtctgg ctctagctat cccgccccta 3540 actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga 3600 ctaatttttt ttatttatgc agaggccgag gccgcctcgg cctctgagct attccagaag 3660 tagtgaggag gcttttttgg aggcctaggg acgtacccaa ttcgccctat agtgagtcgt 3720 attacgcgcg ctcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta 3780 cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg 3840 cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg gacgcgccct 3900 gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg 3960 ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg 4020 gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac 4080 ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct 4140 gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt 4200 tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta taagggattt 4260 tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt 4320 ttaacaaaat attaacgctt acaatttagg tggcactttt cggggaaatg tgcgcggaac 4380 ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc 4440 ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt 4500 cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct 4560 ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga 4620 tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag 4680 cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca 4740 actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga 4800 aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag 4860 tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc 4920 ttttttgcac aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa 4980 tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt 5040 gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg 5100 gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt 5160 tattgctgat aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg 5220 gccagatggt aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat 5280 ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact 5340 gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa 5400 aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt 5460 ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt 5520 ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg 5580 tttgccggat caagagctac caactctttt tccgaaggta actggcttca gcagagcgca 5640 gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca agaactctgt 5700 agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga 5760 taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc 5820 gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact 5880 gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga 5940 caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg 6000 aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt 6060 tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt 6120 acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga 6180 ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac 6240 gaccgagcgc agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc 6300 tctccccgcg cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa 6360 agcgggcagt gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc 6420 tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca 6480 cacaggaaac agctatgacc atgattacgc caagcgcgca attaaccctc actaaaggga 6540 acaaaagctg gagctgcaag cttaatgtag tcttatgcaa tactcttgta gtcttgcaac 6600 atggtaacga tgagttagca acatgcctta caaggagaga aaaagcaccg tgcatgccga 6660 ttggtggaag taaggtggta cgatcgtgcc ttattaggaa ggcaacagac gggtctgaca 6720 tggattggac gaaccactga attgccgcat tgcagagata ttgtatttaa gtgcctagct 6780 cgatacataa acgggtctct ctggttagac cagatctgag cctgggagct ctctggctaa 6840 ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca agtagtgtgt 6900 gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta gtcagtgtgg 6960 aaaatctcta gcagtggcgc ccgaacaggg acttgaaagc gaaagggaaa ccagaggagc 7020 tctctcgacg caggactcgg cttgctgaag cgcgcacggc aagaggcgag gggcggcgac 7080 tggtgagtac gccaaaaatt ttgactagcg gaggctagaa ggagagagat gggtgcgaga 7140 gcgtcagtat taagcggggg agaattagat cgcgatggga aaaaattcgg ttaaggccag 7200 ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag ctagaacgat 7260 tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata ctgggacagc 7320 tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat acagtagcaa 7380 ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct ttagacaaga 7440 tagaggaaga gcaaaacaaa agtaagacca ccgcacagca agcggccgct gatcttcaga 7500 cctggaggag gagatatgag ggacaattgg agaagtgaat tatataaata taaagtagta 7560 aaaattgaac cattaggagt agcacccacc aaggcaaaga gaagagtggt gcagagagaa 7620 aaaagagcag tgggaatagg agctttgttc cttgggttct tgggagcagc aggaagcact 7680 atgggcgcag cgtcaatgac gctgacggta caggccagac aattattgtc tggtatagtg 7740 cagcagcaga acaatttgct gagggctatt gaggcgcaac agcatctgtt gcaactcaca 7800 gtctggggca tcaagcagct ccaggcaaga atcctggctg tggaaagata cctaaaggat 7860 caacagctcc tggggatttg gggttgctct ggaaaactca tttgcaccac tgctgtgcct 7920 tggaatgcta gttggagtaa taaatctctg gaacagattt ggaatcacac gacctggatg 7980 gagtgggaca gagaaattaa caattacaca agcttaatac actccttaat tgaagaatcg 8040 caaaaccagc aagaaaagaa tgaacaagaa ttattggaat tagataaatg ggcaagtttg 8100 tggaattggt ttaacataac aaattggctg tggtatataa aattattcat aatgatagta 8160 ggaggcttgg taggtttaag aatagttttt gctgtacttt ctatagtgaa tagagttagg 8220 cagggatatt caccattatc gtttcagacc cacctcccaa ccccgagggg acccttgcgc 8280 cttttccaag gcagccctgg gtttgcgcag ggacgcggct gctctgggcg tggttccggg 8340 aaacgcagcg gcgccgaccc tgggtctcgc acattcttca cgtccgttcg cagcgtcacc 8400 cggatcttcg ccgctaccct tgtgggcccc ccggcgacgc ttcctgctcc gcccctaagt 8460 cgggaaggtt ccttgcggtt cgcggcgtgc cggacgtgac aaacggaagc cgcacgtctc 8520 actagtaccc tcgcagacgg acagcgccag ggagcaatgg cagcgcgccg accgcgatgg 8580 gctgtggcca atagcggctg ctcagcaggg cgcgccgaga gcagcggccg ggaaggggcg 8640 gtgcgggagg cggggtgtgg ggcggtagtg tgggccctgt tcctgcccgc gcggtgttcc 8700 gcattctgca agcctccgga gcgcacgtcg gcagtcggct ccctcgttga ccgaatcacc 8760 gacctctctc cccagggggt acccagctgt ctagagaatt ctagatcttg agacaaatgg 8820 cagtattcat ccacaatttt aaaagaaaag gggggattgg ggggtacagt gcaggggaaa 8880 gaatagtaga cataatagca acagacatac aaactaaaga attacaaaaa caaattacaa 8940 aaattcaaaa ttttcgggtt tattacaggg acagcagaga tccactttgg cgccggctcg 9000 aggggg 9006 <210> 173 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 173 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Ala Glu Ala Ile Ala Ile Gly Ser Ala Val Ser 35 40 45 Asn Gly Gln Lys Asp Phe Asp Thr Ile Val Ala Val Arg His Pro Tyr 50 55 60 Ser Asp Glu Val Asp Arg Ser Ile Arg Val Val Ser Pro Cys Gly Met 65 70 75 80 Cys Arg Glu Leu Ile Ser Asp Tyr Ala Pro Asp Cys Phe Val Leu Ile 85 90 95 Glu Met Asn Gly Lys Leu Val Lys Thr Thr Ile Glu Glu Leu Ile Pro 100 105 110 Leu Lys Tyr Thr Arg Asn 115 <210> 174 <211> 9531 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 174 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcgccgatg gtttctacaa agatcgttat 780 gtttatcggc actttgcatc ggccgcgctc ccgattccgg aagtgcttga cattggggaa 840 tttagcgaga gcctgaccta ttgcatctcc cgccgtgcac agggtgtcac gttgcaagac 900 ctgcctgaaa ccgaactgcc cgctgttctg cagccggtcg cggaggccat ggatgcgatc 960 gctgcggccg atcttagcca gacgagcggg ttcggcccat tcggaccgca aggaatcggt 1020 caatacacta catggcgtga tttcatatgc gcgattgctg atccccatgt gtatcactgg 1080 caaactgtga tggacgacac cgtcagtgcg tccgtcgcgc aggctctcga tgagctgatg 1140 ctttgggccg aggactgccc cgaagtccgg cacctcgtgc acgcggattt cggctgtatc 1200 agtggcgact ccctgatctc actcgcaagc actggaaagc gagttagcat caaggacttg 1260 ctggacgaaa aggatttcga aatttgggca atcaatgagc agaccatgaa actggagtct 1320 gcaaaggtgt cccgggtgtt ttgcacgggt aagaagcttg tttatatcct taaaactaga 1380 ctgggccgga cgatcaaagc caccgcgaac cacagattct tgacaatcga cgggtggaaa 1440 cggctggacg aactgagctt gaaggagcac atcgcccttc ctcggaagct cgagtcatct 1500 tccctgcagc tgtgattaat taagaattcg acccagcttt cttgtacaaa gtggttggta 1560 agcctatccc taaccctctc ctcggtctcg attctacgta gtaatgagct agcagtctcg 1620 aggttaacga attccgcccc ccccctaacg ttactggccg aagccgcttg gaataaggcc 1680 ggtgtgcgct tgtctatatg ttattttcca ccatattgcc gtcttttggc aatgtgaggg 1740 cccggaaacc tggccctgtc ttcttgacga gcattcctag gggtctttcc cctctcgcca 1800 aaggaatgca aggtctgttg aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa 1860 gacaaacaac gtctgtagcg accctttgca ggcagcggaa ccccccacct ggcgacaggt 1920 gcccctgcgg ccaaaagcca cgtgtataag atacacctgc aaaggcggca caaccccagt 1980 gccacgttgt gagttggata gttgtggaaa gagtcaaatg gctctcctca agcgtattca 2040 acaaggggct gaaggatgcc cagaaggtac cccattgtat gggatctgat ctggggcctc 2100 ggtgcacatg ctttacatgt gtttagtcga ggttaaaaaa acgtctaggc cccccgaacc 2160 acggggacgt ggttttcctt tgaaaaacac gataatacca tggtgagcaa gggcgaggag 2220 ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cggccacaag 2280 ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac cctgaagttc 2340 atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac cctgacctac 2400 ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt cttcaagtcc 2460 gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga cggcaactac 2520 aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat cgagctgaag 2580 ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta caactacaac 2640 agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt gaacttcaag 2700 atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca gcagaacacc 2760 cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac ccagtccgcc 2820 ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc 2880 gccgggatca ctctcggcat ggacgagctg tacaagtaac accggtggcg cgttaagtcg 2940 acaatcaacc tctggattac aaaatttgtg aaagattgac tggtattctt aactatgttg 3000 ctccttttac gctatgtgga tacgctgctt taatgccttt gtatcatgct attgcttccc 3060 gtatggcttt cattttctcc tccttgtata aatcctggtt gctgtctctt tatgaggagt 3120 tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac gcaaccccca 3180 ctggttgggg cattgccacc acctgtcagc tcctttccgg gactttcgct ttccccctcc 3240 ctattgccac ggcggaactc atcgccgcct gccttgcccg ctgctggaca ggggctcggc 3300 tgttgggcac tgacaattcc gtggtgttgt cggggaaatc atcgtccttt ccttggctgc 3360 tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc ccttcggccc 3420 tcaatccagc ggaccttcct tcccgcggcc tgctgccggc tctgcggcct cttccgcgtc 3480 ttcgccttcg ccctcagacg agtcggatct ccctttgggc cgcctccccg cgtcgacttt 3540 aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag aaaagggggg 3600 actggaaggg ctaattcact cccaacgaag acaagatctg ctttttgctt gtactgggtc 3660 tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct 3720 taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga 3780 ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtac 3840 gtatagtagt tcatgtcatc ttattattca gtatttataa cttgcaaaga aatgaatatc 3900 agagagtgag aggaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat 3960 cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact 4020 catcaatgta tcttatcatg tctggctcta gctatcccgc ccctaactcc gcccatcccg 4080 cccctaactc cgcccagttc cgcccattct ccgccccatg gctgactaat tttttttatt 4140 tatgcagagg ccgaggccgc ctcggcctct gagctattcc agaagtagtg aggaggcttt 4200 tttggaggcc tagggacgta cccaattcgc cctatagtga gtcgtattac gcgcgctcac 4260 tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg cgttacccaa cttaatcgcc 4320 ttgcagcaca tccccctttc gccagctggc gtaatagcga agaggcccgc accgatcgcc 4380 cttcccaaca gttgcgcagc ctgaatggcg aatgggacgc gccctgtagc ggcgcattaa 4440 gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc gccctagcgc 4500 ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag 4560 ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac ctcgacccca 4620 aaaaacttga ttagggtgat ggttcacgta gtgggccatc gccctgatag acggtttttc 4680 gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa actggaacaa 4740 cactcaaccc tatctcggtc tattcttttg atttataagg gattttgccg atttcggcct 4800 attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattttaac aaaatattaa 4860 cgcttacaat ttaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt 4920 tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca 4980 ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt 5040 ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga 5100 tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa 5160 gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct 5220 gctatgtggc gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat 5280 acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga 5340 tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc 5400 caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat 5460 gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa 5520 cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac 5580 tggcgaacta cttactctag cttcccggca acaattaata gactggatgg aggcggataa 5640 agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc 5700 tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc 5760 ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag 5820 acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag accaagttta 5880 ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa 5940 gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc 6000 gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat 6060 ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga 6120 gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt 6180 tcttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata 6240 cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac 6300 cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg 6360 ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg 6420 tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag 6480 cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct 6540 ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc 6600 aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt 6660 ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg 6720 tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga 6780 gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg 6840 gccgattcat taatgcagct ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg 6900 caacgcaatt aatgtgagtt agctcactca ttaggcaccc caggctttac actttatgct 6960 tccggctcgt atgttgtgtg gaattgtgag cggataacaa tttcacacag gaaacagcta 7020 tgaccatgat tacgccaagc gcgcaattaa ccctcactaa agggaacaaa agctggagct 7080 gcaagcttaa tgtagtctta tgcaatactc ttgtagtctt gcaacatggt aacgatgagt 7140 tagcaacatg ccttacaagg agagaaaaag caccgtgcat gccgattggt ggaagtaagg 7200 tggtacgatc gtgccttatt aggaaggcaa cagacgggtc tgacatggat tggacgaacc 7260 actgaattgc cgcattgcag agatattgta tttaagtgcc tagctcgata cataaacggg 7320 tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg 7380 cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt 7440 gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt 7500 ggcgcccgaa cagggacttg aaagcgaaag ggaaaccaga ggagctctct cgacgcagga 7560 ctcggcttgc tgaagcgcgc acggcaagag gcgaggggcg gcgactggtg agtacgccaa 7620 aaattttgac tagcggaggc tagaaggaga gagatgggtg cgagagcgtc agtattaagc 7680 gggggagaat tagatcgcga tgggaaaaaa ttcggttaag gccaggggga aagaaaaaat 7740 ataaattaaa acatatagta tgggcaagca gggagctaga acgattcgca gttaatcctg 7800 gcctgttaga aacatcagaa ggctgtagac aaatactggg acagctacaa ccatcccttc 7860 agacaggatc agaagaactt agatcattat ataatacagt agcaaccctc tattgtgtgc 7920 atcaaaggat agagataaaa gacaccaagg aagctttaga caagatagag gaagagcaaa 7980 acaaaagtaa gaccaccgca cagcaagcgg ccgctgatct tcagacctgg aggaggagat 8040 atgagggaca attggagaag tgaattatat aaatataaag tagtaaaaat tgaaccatta 8100 ggagtagcac ccaccaaggc aaagagaaga gtggtgcaga gagaaaaaag agcagtggga 8160 ataggagctt tgttccttgg gttcttggga gcagcaggaa gcactatggg cgcagcgtca 8220 atgacgctga cggtacaggc cagacaatta ttgtctggta tagtgcagca gcagaacaat 8280 ttgctgaggg ctattgaggc gcaacagcat ctgttgcaac tcacagtctg gggcatcaag 8340 cagctccagg caagaatcct ggctgtggaa agatacctaa aggatcaaca gctcctgggg 8400 atttggggtt gctctggaaa actcatttgc accactgctg tgccttggaa tgctagttgg 8460 agtaataaat ctctggaaca gatttggaat cacacgacct ggatggagtg ggacagagaa 8520 attaacaatt acacaagctt aatacactcc ttaattgaag aatcgcaaaa ccagcaagaa 8580 aagaatgaac aagaattatt ggaattagat aaatgggcaa gtttgtggaa ttggtttaac 8640 ataacaaatt ggctgtggta tataaaatta ttcataatga tagtaggagg cttggtaggt 8700 ttaagaatag tttttgctgt actttctata gtgaatagag ttaggcaggg atattcacca 8760 ttatcgtttc agacccacct cccaaccccg aggggaccct tgcgcctttt ccaaggcagc 8820 cctgggtttg cgcagggacg cggctgctct gggcgtggtt ccgggaaacg cagcggcgcc 8880 gaccctgggt ctcgcacatt cttcacgtcc gttcgcagcg tcacccggat cttcgccgct 8940 acccttgtgg gccccccggc gacgcttcct gctccgcccc taagtcggga aggttccttg 9000 cggttcgcgg cgtgccggac gtgacaaacg gaagccgcac gtctcactag taccctcgca 9060 gacggacagc gccagggagc aatggcagcg cgccgaccgc gatgggctgt ggccaatagc 9120 ggctgctcag cagggcgcgc cgagagcagc ggccgggaag gggcggtgcg ggaggcgggg 9180 tgtggggcgg tagtgtgggc cctgttcctg cccgcgcggt gttccgcatt ctgcaagcct 9240 ccggagcgca cgtcggcagt cggctccctc gttgaccgaa tcaccgacct ctctccccag 9300 ggggtaccca gctgtctaga gaattctaga tcttgagaca aatggcagta ttcatccaca 9360 attttaaaag aaaagggggg attggggggt acagtgcagg ggaaagaata gtagacataa 9420 tagcaacaga catacaaact aaagaattac aaaaacaaat tacaaaaatt caaaattttc 9480 gggtttatta cagggacagc agagatccac tttggcgccg gctcgagggg g 9531 <210> 175 <211> 290 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 175 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 35 40 45 Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 50 55 60 Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala Gln 65 70 75 80 Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu 85 90 95 Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser 100 105 110 Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr 115 120 125 Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr 130 135 140 His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln 145 150 155 160 Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg 165 170 175 His Leu Val His Ala Asp Phe Gly Cys Ile Ser Gly Asp Ser Leu Ile 180 185 190 Ser Leu Ala Ser Thr Gly Lys Arg Val Ser Ile Lys Asp Leu Leu Asp 195 200 205 Glu Lys Asp Phe Glu Ile Trp Ala Ile Asn Glu Gln Thr Met Lys Leu 210 215 220 Glu Ser Ala Lys Val Ser Arg Val Phe Cys Thr Gly Lys Lys Leu Val 225 230 235 240 Tyr Ile Leu Lys Thr Arg Leu Gly Arg Thr Ile Lys Ala Thr Ala Asn 245 250 255 His Arg Phe Leu Thr Ile Asp Gly Trp Lys Arg Leu Asp Glu Leu Ser 260 265 270 Leu Lys Glu His Ile Ala Leu Pro Arg Lys Leu Glu Ser Ser Ser Leu 275 280 285 Gln Leu 290 <210> 176 <211> 9222 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 176 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgagtcc cgaaatcgaa 660 aagctctctc agagcgatat atattgggac tccatcgtaa gcataacaga gacgggggtc 720 gaggaggtgt tcgatctgac agttcctggg cctcataatt tcgtagcgaa cgacatcatt 780 gtacataact ccaacaatgt cctgacggac aatggccgca taacagcggt cattgactgg 840 agcgaggcga tgttcgggga ttcccaatac gaggtcgcca acatcttctt ctggaggccg 900 tggttggctt gtatggagca gcagacgcgc tacttcgagc ggaggcatcc ggagcttgca 960 ggatcgccgc ggctccgggc gtatatgctc cgcattggtc ttgaccaact ctatcagagc 1020 ttggttgacg gcaatttcga tgatgcagct tgggcgcagg gtcgatgcga cgcaatcgtc 1080 cgatccggag ccgggactgt cgggcgtaca caaatcgccc gcagaagcgc ggccgtctgg 1140 accgatggct gtgtagaagt actcgccgat agtggaaacc gacgccccag cactcgtccg 1200 agggcaaagg aatagttaat taagaattcg acccagcttt cttgtacaaa gtggttggta 1260 agcctatccc taaccctctc ctcggtctcg attctacgta gtaatgagct agcagtctcg 1320 aggttaacga attccgcccc ccccctaacg ttactggccg aagccgcttg gaataaggcc 1380 ggtgtgcgct tgtctatatg ttattttcca ccatattgcc gtcttttggc aatgtgaggg 1440 cccggaaacc tggccctgtc ttcttgacga gcattcctag gggtctttcc cctctcgcca 1500 aaggaatgca aggtctgttg aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa 1560 gacaaacaac gtctgtagcg accctttgca ggcagcggaa ccccccacct ggcgacaggt 1620 gcccctgcgg ccaaaagcca cgtgtataag atacacctgc aaaggcggca caaccccagt 1680 gccacgttgt gagttggata gttgtggaaa gagtcaaatg gctctcctca agcgtattca 1740 acaaggggct gaaggatgcc cagaaggtac cccattgtat gggatctgat ctggggcctc 1800 ggtgcacatg ctttacatgt gtttagtcga ggttaaaaaa acgtctaggc cccccgaacc 1860 acggggacgt ggttttcctt tgaaaaacac gataatacca tggtgagcaa gggcgaggag 1920 gataacatgg ccatcatcaa ggagttcatg cgcttcaagg tgcacatgga gggctccgtg 1980 aacggccacg agttcgagat cgagggcgag ggcgagggcc gcccctacga gggcacccag 2040 accgccaagc tgaaggtgac caagggtggc cccctgccct tcgcctggga catcctgtcc 2100 cctcagttca tgtacggctc caaggcctac gtgaagcacc ccgccgacat ccccgactac 2160 ttgaagctgt ccttccccga gggcttcaag tgggagcgcg tgatgaactt cgaggacggc 2220 ggcgtggtga ccgtgaccca ggactcctcc ctgcaggacg gcgagttcat ctacaaggtg 2280 aagctgcgcg gcaccaactt cccctccgac ggccccgtaa tgcagaagaa gaccatgggc 2340 tgggaggcct cctccgagcg gatgtacccc gaggacggcg ccctgaaggg cgagatcaag 2400 cagaggctga agctgaagga cggcggccac tacgacgctg aggtcaagac cacctacaag 2460 gccaagaagc ccgtgcagct gcccggcgcc tacaacgtca acatcaagtt ggacatcacc 2520 tcccacaacg aggactacac catcgtggaa cagtacgaac gcgccgaggg ccgccactcc 2580 accggcggca tggacgagct gtacaagtaa caccggtggc gcgttaagtc gacaatcaac 2640 ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta 2700 cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt 2760 tcattttctc ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg 2820 ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg 2880 gcattgccac cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca 2940 cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca 3000 ctgacaattc cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg 3060 ttgccacctg gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag 3120 cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc 3180 gccctcagac gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat 3240 gacttacaag gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg 3300 gctaattcac tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt 3360 agaccagatc tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca 3420 ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa 3480 ctagagatcc ctcagaccct tttagtcagt gtggaaaatc tctagcagta cgtatagtag 3540 ttcatgtcat cttattattc agtatttata acttgcaaag aaatgaatat cagagagtga 3600 gaggaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt 3660 cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt 3720 atcttatcat gtctggctct agctatcccg cccctaactc cgcccatccc gcccctaact 3780 ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag 3840 gccgaggccg cctcggcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc 3900 ctagggacgt acccaattcg ccctatagtg agtcgtatta cgcgcgctca ctggccgtcg 3960 ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc cttgcagcac 4020 atcccccttt cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac 4080 agttgcgcag cctgaatggc gaatgggacg cgccctgtag cggcgcatta agcgcggcgg 4140 gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt 4200 tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc 4260 gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg 4320 attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga 4380 cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc 4440 ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa 4500 aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta acgcttacaa 4560 tttaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat 4620 acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg 4680 aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc 4740 attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga 4800 tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga 4860 gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg 4920 cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc 4980 tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac 5040 agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact 5100 tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca 5160 tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg 5220 tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact 5280 acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg 5340 accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg 5400 tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat 5460 cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc 5520 tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat 5580 actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt 5640 tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc 5700 cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt 5760 gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac 5820 tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt 5880 gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct 5940 gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga 6000 ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac 6060 acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg 6120 agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt 6180 cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc 6240 tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg 6300 gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc 6360 ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc 6420 ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag 6480 cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca 6540 ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc gcaacgcaat 6600 taatgtgagt tagctcactc attaggcacc ccaggcttta cactttatgc ttccggctcg 6660 tatgttgtgt ggaattgtga gcggataaca atttcacaca ggaaacagct atgaccatga 6720 ttacgccaag cgcgcaatta accctcacta aagggaacaa aagctggagc tgcaagctta 6780 atgtagtctt atgcaatact cttgtagtct tgcaacatgg taacgatgag ttagcaacat 6840 gccttacaag gagagaaaaa gcaccgtgca tgccgattgg tggaagtaag gtggtacgat 6900 cgtgccttat taggaaggca acagacgggt ctgacatgga ttggacgaac cactgaattg 6960 ccgcattgca gagatattgt atttaagtgc ctagctcgat acataaacgg gtctctctgg 7020 ttagaccaga tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct 7080 caataaagct tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt 7140 aactagagat ccctcagacc cttttagtca gtgtggaaaa tctctagcag tggcgcccga 7200 acagggactt gaaagcgaaa gggaaaccag aggagctctc tcgacgcagg actcggcttg 7260 ctgaagcgcg cacggcaaga ggcgaggggc ggcgactggt gagtacgcca aaaattttga 7320 ctagcggagg ctagaaggag agagatgggt gcgagagcgt cagtattaag cgggggagaa 7380 ttagatcgcg atgggaaaaa attcggttaa ggccaggggg aaagaaaaaa tataaattaa 7440 aacatatagt atgggcaagc agggagctag aacgattcgc agttaatcct ggcctgttag 7500 aaacatcaga aggctgtaga caaatactgg gacagctaca accatccctt cagacaggat 7560 cagaagaact tagatcatta tataatacag tagcaaccct ctattgtgtg catcaaagga 7620 tagagataaa agacaccaag gaagctttag acaagataga ggaagagcaa aacaaaagta 7680 agaccaccgc acagcaagcg gccgctgatc ttcagacctg gaggaggaga tatgagggac 7740 aattggagaa gtgaattata taaatataaa gtagtaaaaa ttgaaccatt aggagtagca 7800 cccaccaagg caaagagaag agtggtgcag agagaaaaaa gagcagtggg aataggagct 7860 ttgttccttg ggttcttggg agcagcagga agcactatgg gcgcagcgtc aatgacgctg 7920 acggtacagg ccagacaatt attgtctggt atagtgcagc agcagaacaa tttgctgagg 7980 gctattgagg cgcaacagca tctgttgcaa ctcacagtct ggggcatcaa gcagctccag 8040 gcaagaatcc tggctgtgga aagataccta aaggatcaac agctcctggg gatttggggt 8100 tgctctggaa aactcatttg caccactgct gtgccttgga atgctagttg gagtaataaa 8160 tctctggaac agatttggaa tcacacgacc tggatggagt gggacagaga aattaacaat 8220 tacacaagct taatacactc cttaattgaa gaatcgcaaa accagcaaga aaagaatgaa 8280 caagaattat tggaattaga taaatgggca agtttgtgga attggtttaa cataacaaat 8340 tggctgtggt atataaaatt attcataatg atagtaggag gcttggtagg tttaagaata 8400 gtttttgctg tactttctat agtgaataga gttaggcagg gatattcacc attatcgttt 8460 cagacccacc tcccaacccc gaggggaccc ttgcgccttt tccaaggcag ccctgggttt 8520 gcgcagggac gcggctgctc tgggcgtggt tccgggaaac gcagcggcgc cgaccctggg 8580 tctcgcacat tcttcacgtc cgttcgcagc gtcacccgga tcttcgccgc tacccttgtg 8640 ggccccccgg cgacgcttcc tgctccgccc ctaagtcggg aaggttcctt gcggttcgcg 8700 gcgtgccgga cgtgacaaac ggaagccgca cgtctcacta gtaccctcgc agacggacag 8760 cgccagggag caatggcagc gcgccgaccg cgatgggctg tggccaatag cggctgctca 8820 gcagggcgcg ccgagagcag cggccgggaa ggggcggtgc gggaggcggg gtgtggggcg 8880 gtagtgtggg ccctgttcct gcccgcgcgg tgttccgcat tctgcaagcc tccggagcgc 8940 acgtcggcag tcggctccct cgttgaccga atcaccgacc tctctcccca gggggtaccc 9000 agctgtctag agaattctag atcttgagac aaatggcagt attcatccac aattttaaaa 9060 gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata atagcaacag 9120 acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt cgggtttatt 9180 acagggacag cagagatcca ctttggcgcc ggctcgaggg gg 9222 <210> 177 <211> 190 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 177 Met Ser Pro Glu Ile Glu Lys Leu Ser Gln Ser Asp Ile Tyr Trp Asp 1 5 10 15 Ser Ile Val Ser Ile Thr Glu Thr Gly Val Glu Glu Val Phe Asp Leu 20 25 30 Thr Val Pro Gly Pro His Asn Phe Val Ala Asn Asp Ile Ile Val His 35 40 45 Asn Ser Asn Asn Val Leu Thr Asp Asn Gly Arg Ile Thr Ala Val Ile 50 55 60 Asp Trp Ser Glu Ala Met Phe Gly Asp Ser Gln Tyr Glu Val Ala Asn 65 70 75 80 Ile Phe Phe Trp Arg Pro Trp Leu Ala Cys Met Glu Gln Gln Thr Arg 85 90 95 Tyr Phe Glu Arg Arg His Pro Glu Leu Ala Gly Ser Pro Arg Leu Arg 100 105 110 Ala Tyr Met Leu Arg Ile Gly Leu Asp Gln Leu Tyr Gln Ser Leu Val 115 120 125 Asp Gly Asn Phe Asp Asp Ala Ala Trp Ala Gln Gly Arg Cys Asp Ala 130 135 140 Ile Val Arg Ser Gly Ala Gly Thr Val Gly Arg Thr Gln Ile Ala Arg 145 150 155 160 Arg Ser Ala Ala Val Trp Thr Asp Gly Cys Val Glu Val Leu Ala Asp 165 170 175 Ser Gly Asn Arg Arg Pro Ser Thr Arg Pro Arg Ala Lys Glu 180 185 190 <210> 178 <211> 9420 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 178 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgattaa gatcgctacg 660 cggaagtacc tggggaaaca gaacgtctac gacataggtg tggagcgcga tcacaacttt 720 gctctgaaaa atggatttat cgccagcaac tgcatctccc gccgtgcaca gggtgtcacg 780 ttgcaagacc tgcctgaaac cgaactgccc gctgttctgc agccggtcgc ggaggccatg 840 gatgcgatcg ctgcggccga tcttagccag acgagcgggt tcggcccatt cggaccgcaa 900 ggaatcggtc aatacactac atggcgtgat ttcatatgcg cgattgctga tccccatgtg 960 tatcactggc aaactgtgat ggacgacacc gtcagtgcgt ccgtcgcgca ggctctcgat 1020 gagctgatgc tttgggccga ggactgcccc gaagtccggc acctcgtgca cgcggatttc 1080 ggctgtatca gtggcgactc cctgatctca ctcgcaagca ctggaaagcg agttagcatc 1140 aaggacttgc tggacgaaaa ggatttcgaa atttgggcaa tcaatgagca gaccatgaaa 1200 ctggagtctg caaaggtgtc ccgggtgttt tgcacgggta agaagcttgt ttatatcctt 1260 aaaactagac tgggccggac gatcaaagcc accgcgaacc acagattctt gacaatcgac 1320 gggtggaaac ggctggacga actgagcttg aaggagcaca tcgcccttcc tcggaagctc 1380 gagtcatctt ccctgcagct gtgattaatt aagaattcga cccagctttc ttgtacaaag 1440 tggttggtaa gcctatccct aaccctctcc tcggtctcga ttctacgtag taatgagcta 1500 gcagtctcga ggttaacgaa ttccgccccc cccctaacgt tactggccga agccgcttgg 1560 aataaggccg gtgtgcgctt gtctatatgt tattttccac catattgccg tcttttggca 1620 atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg ggtctttccc 1680 ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt cctctggaag 1740 cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac cccccacctg 1800 gcgacaggtg cccctgcggc caaaagccac gtgtataaga tacacctgca aaggcggcac 1860 aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg ctctcctcaa 1920 gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg ggatctgatc 1980 tggggcctcg gtgcacatgc tttacatgtg tttagtcgag gttaaaaaaa cgtctaggcc 2040 ccccgaacca cggggacgtg gttttccttt gaaaaacacg ataataccat ggtgagcaag 2100 ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac 2160 ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg caagctgacc 2220 ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc 2280 ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc 2340 ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt caaggacgac 2400 ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc 2460 gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac 2520 aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg catcaaggtg 2580 aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga ccactaccag 2640 cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagcacc 2700 cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc 2760 gtgaccgccg ccgggatcac tctcggcatg gacgagctgt acaagtaaca ccggtggcgc 2820 gttaagtcga caatcaacct ctggattaca aaatttgtga aagattgact ggtattctta 2880 actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta 2940 ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt 3000 atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg 3060 caacccccac tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt 3120 tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag 3180 gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaaatca tcgtcctttc 3240 cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc 3300 cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc 3360 ttccgcgtct tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc 3420 gtcgacttta agaccaatga cttacaaggc agctgtagat cttagccact ttttaaaaga 3480 aaagggggga ctggaagggc taattcactc ccaacgaaga caagatctgc tttttgcttg 3540 tactgggtct ctctggttag accagatctg agcctgggag ctctctggct aactagggaa 3600 cccactgctt aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct 3660 gttgtgtgac tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc 3720 tagcagtacg tatagtagtt catgtcatct tattattcag tatttataac ttgcaaagaa 3780 atgaatatca gagagtgaga ggaacttgtt tattgcagct tataatggtt acaaataaag 3840 caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt 3900 gtccaaactc atcaatgtat cttatcatgt ctggctctag ctatcccgcc cctaactccg 3960 cccatcccgc ccctaactcc gcccagttcc gcccattctc cgccccatgg ctgactaatt 4020 ttttttattt atgcagaggc cgaggccgcc tcggcctctg agctattcca gaagtagtga 4080 ggaggctttt ttggaggcct agggacgtac ccaattcgcc ctatagtgag tcgtattacg 4140 cgcgctcact ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac 4200 ttaatcgcct tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca 4260 ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atgggacgcg ccctgtagcg 4320 gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg 4380 ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc 4440 cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc 4500 tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga 4560 cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa 4620 ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg attttgccga 4680 tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattttaaca 4740 aaatattaac gcttacaatt taggtggcac ttttcgggga aatgtgcgcg gaacccctat 4800 ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata 4860 aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct 4920 tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa 4980 agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa 5040 cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt 5100 taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg 5160 tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca 5220 tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa 5280 cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt 5340 gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc 5400 cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa 5460 actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga 5520 ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc 5580 tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga 5640 tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga 5700 acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga 5760 ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat 5820 ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt 5880 ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct 5940 gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc 6000 ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc 6060 aaatactgtt cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc 6120 gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc 6180 gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg 6240 aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata 6300 cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta 6360 tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc 6420 ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg 6480 atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt 6540 cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt 6600 ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga 6660 gcgcagcgag tcagtgagcg aggaagcgga agagcgccca atacgcaaac cgcctctccc 6720 cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg tttcccgact ggaaagcggg 6780 cagtgagcgc aacgcaatta atgtgagtta gctcactcat taggcacccc aggctttaca 6840 ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc ggataacaat ttcacacagg 6900 aaacagctat gaccatgatt acgccaagcg cgcaattaac cctcactaaa gggaacaaaa 6960 gctggagctg caagcttaat gtagtcttat gcaatactct tgtagtcttg caacatggta 7020 acgatgagtt agcaacatgc cttacaagga gagaaaaagc accgtgcatg ccgattggtg 7080 gaagtaaggt ggtacgatcg tgccttatta ggaaggcaac agacgggtct gacatggatt 7140 ggacgaacca ctgaattgcc gcattgcaga gatattgtat ttaagtgcct agctcgatac 7200 ataaacgggt ctctctggtt agaccagatc tgagcctggg agctctctgg ctaactaggg 7260 aacccactgc ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt 7320 ctgttgtgtg actctggtaa ctagagatcc ctcagaccct tttagtcagt gtggaaaatc 7380 tctagcagtg gcgcccgaac agggacttga aagcgaaagg gaaaccagag gagctctctc 7440 gacgcaggac tcggcttgct gaagcgcgca cggcaagagg cgaggggcgg cgactggtga 7500 gtacgccaaa aattttgact agcggaggct agaaggagag agatgggtgc gagagcgtca 7560 gtattaagcg ggggagaatt agatcgcgat gggaaaaaat tcggttaagg ccagggggaa 7620 agaaaaaata taaattaaaa catatagtat gggcaagcag ggagctagaa cgattcgcag 7680 ttaatcctgg cctgttagaa acatcagaag gctgtagaca aatactggga cagctacaac 7740 catcccttca gacaggatca gaagaactta gatcattata taatacagta gcaaccctct 7800 attgtgtgca tcaaaggata gagataaaag acaccaagga agctttagac aagatagagg 7860 aagagcaaaa caaaagtaag accaccgcac agcaagcggc cgctgatctt cagacctgga 7920 ggaggagata tgagggacaa ttggagaagt gaattatata aatataaagt agtaaaaatt 7980 gaaccattag gagtagcacc caccaaggca aagagaagag tggtgcagag agaaaaaaga 8040 gcagtgggaa taggagcttt gttccttggg ttcttgggag cagcaggaag cactatgggc 8100 gcagcgtcaa tgacgctgac ggtacaggcc agacaattat tgtctggtat agtgcagcag 8160 cagaacaatt tgctgagggc tattgaggcg caacagcatc tgttgcaact cacagtctgg 8220 ggcatcaagc agctccaggc aagaatcctg gctgtggaaa gatacctaaa ggatcaacag 8280 ctcctgggga tttggggttg ctctggaaaa ctcatttgca ccactgctgt gccttggaat 8340 gctagttgga gtaataaatc tctggaacag atttggaatc acacgacctg gatggagtgg 8400 gacagagaaa ttaacaatta cacaagctta atacactcct taattgaaga atcgcaaaac 8460 cagcaagaaa agaatgaaca agaattattg gaattagata aatgggcaag tttgtggaat 8520 tggtttaaca taacaaattg gctgtggtat ataaaattat tcataatgat agtaggaggc 8580 ttggtaggtt taagaatagt ttttgctgta ctttctatag tgaatagagt taggcaggga 8640 tattcaccat tatcgtttca gacccacctc ccaaccccga ggggaccctt gcgccttttc 8700 caaggcagcc ctgggtttgc gcagggacgc ggctgctctg ggcgtggttc cgggaaacgc 8760 agcggcgccg accctgggtc tcgcacattc ttcacgtccg ttcgcagcgt cacccggatc 8820 ttcgccgcta cccttgtggg ccccccggcg acgcttcctg ctccgcccct aagtcgggaa 8880 ggttccttgc ggttcgcggc gtgccggacg tgacaaacgg aagccgcacg tctcactagt 8940 accctcgcag acggacagcg ccagggagca atggcagcgc gccgaccgcg atgggctgtg 9000 gccaatagcg gctgctcagc agggcgcgcc gagagcagcg gccgggaagg ggcggtgcgg 9060 gaggcggggt gtggggcggt agtgtgggcc ctgttcctgc ccgcgcggtg ttccgcattc 9120 tgcaagcctc cggagcgcac gtcggcagtc ggctccctcg ttgaccgaat caccgacctc 9180 tctccccagg gggtacccag ctgtctagag aattctagat cttgagacaa atggcagtat 9240 tcatccacaa ttttaaaaga aaagggggga ttggggggta cagtgcaggg gaaagaatag 9300 tagacataat agcaacagac atacaaacta aagaattaca aaaacaaatt acaaaaattc 9360 aaaattttcg ggtttattac agggacagca gagatccact ttggcgccgg ctcgaggggg 9420 <210> 179 <211> 253 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 179 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn Cys Ile Ser Arg Arg Ala Gln Gly Val Thr Leu Gln 35 40 45 Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu Gln Pro Val Ala Glu 50 55 60 Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser Gln Thr Ser Gly Phe 65 70 75 80 Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr Thr Thr Trp Arg Asp 85 90 95 Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr His Trp Gln Thr Val 100 105 110 Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln Ala Leu Asp Glu Leu 115 120 125 Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg His Leu Val His Ala 130 135 140 Asp Phe Gly Cys Ile Ser Gly Asp Ser Leu Ile Ser Leu Ala Ser Thr 145 150 155 160 Gly Lys Arg Val Ser Ile Lys Asp Leu Leu Asp Glu Lys Asp Phe Glu 165 170 175 Ile Trp Ala Ile Asn Glu Gln Thr Met Lys Leu Glu Ser Ala Lys Val 180 185 190 Ser Arg Val Phe Cys Thr Gly Lys Lys Leu Val Tyr Ile Leu Lys Thr 195 200 205 Arg Leu Gly Arg Thr Ile Lys Ala Thr Ala Asn His Arg Phe Leu Thr 210 215 220 Ile Asp Gly Trp Lys Arg Leu Asp Glu Leu Ser Leu Lys Glu His Ile 225 230 235 240 Ala Leu Pro Arg Lys Leu Glu Ser Ser Ser Leu Gln Leu 245 250 <210> 180 <211> 9564 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 180 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaaaaagcc tgaactcacc 660 gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 720 ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc 780 ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt 840 gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaatttag cgagagcctg 900 acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa 960 ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt 1020 agccagacga gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg 1080 cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac tgtgatggac 1140 gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc tgatgctttg ggccgaggac 1200 tgccccgaag tccggcacct cgtgcacgcg gatttcggct gtatcagtgg cgactccctg 1260 atctcactcg caagcactgg aaagcgagtt agcatcaagg acttgctgga cgaaaaggat 1320 ttcgaaattt gggcaatcaa tgagcagacc atgaaactgg agtctgcaaa ggtgtcccgg 1380 gtgttttgca cgggtaagaa gcttgtttat atccttaaaa ctagactggg ccggacgatc 1440 aaagccaccg cgaaccacag attcttgaca atcgacgggt ggaaacggct ggacgaactg 1500 agcttgaagg agcacatcgc ccttcctcgg aagctcgagt catcttccct gcagctgtga 1560 ttaattaaga attcgaccca gctttcttgt acaaagtggt tggtaagcct atccctaacc 1620 ctctcctcgg tctcgattct acgtagtaat gagctagcag tctcgaggtt aacgaattcc 1680 gccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt gcgcttgtct 1740 atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc 1800 ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc 1860 tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg 1920 tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcccc tgcggccaaa 1980 agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt 2040 ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg 2100 atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta 2160 catgtgttta gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt 2220 tcctttgaaa aacacgataa taccatggcc atgagcgagc tgattaagga gaacatgcac 2280 atgaagctgt acatggaggg caccgtggac aaccatcact tcaagtgcac atccgagggc 2340 gaaggcaagc cctacgaggg cacccagacc atgagaatca aggtggtcga gggcggccct 2400 ctccccttcg ccttcgacat cctggctact agcttcctct acggcagcaa gaccttcatc 2460 aaccacaccc agggcatccc cgacttcttc aagcagtcct tccctgaggg cttcacatgg 2520 gagagagtca ccacatacga agacgggggc gtgctgaccg ctacccagga caccagcctc 2580 caggacggct gcctcatcta caacgtcaag atcagagggg tgaacttcac atccaacggc 2640 cctgtgatgc agaagaaaac actcggctgg gaggccttca ccgagacgct gtaccccgct 2700 gacggcggcc tggaaggcag aaacgacatg gccctgaagc tcgtgggcgg gagccatctg 2760 atcgcaaaca tcaagaccac atatagatcc aagaaacccg ctaagaacct caagatgcct 2820 ggcgtctact atgtggacta cagactggaa agaatcaagg aggccaacaa cgagacctac 2880 gtcgagcagc acgaggtggc agtggccaga tactgcgacc tccctagcaa actggggcac 2940 aagcttaatt aacaccggtg gcgcgttaag tcgacaatca acctctggat tacaaaattt 3000 gtgaaagatt gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg 3060 ctttaatgcc tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt 3120 ataaatcctg gttgctgtct ctttatgagg agttgtggcc cgttgtcagg caacgtggcg 3180 tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg gggcattgcc accacctgtc 3240 agctcctttc cgggactttc gctttccccc tccctattgc cacggcggaa ctcatcgccg 3300 cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt 3360 tgtcggggaa atcatcgtcc tttccttggc tgctcgcctg tgttgccacc tggattctgc 3420 gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg 3480 gcctgctgcc ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga 3540 tctccctttg ggccgcctcc ccgcgtcgac tttaagacca atgacttaca aggcagctgt 3600 agatcttagc cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaacg 3660 aagacaagat ctgctttttg cttgtactgg gtctctctgg ttagaccaga tctgagcctg 3720 ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt 3780 gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc 3840 cttttagtca gtgtggaaaa tctctagcag tacgtatagt agttcatgtc atcttattat 3900 tcagtattta taacttgcaa agaaatgaat atcagagagt gagaggaact tgtttattgc 3960 agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt 4020 ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggct 4080 ctagctatcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat 4140 tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc 4200 tctgagctat tccagaagta gtgaggaggc ttttttggag gcctagggac gtacccaatt 4260 cgccctatag tgagtcgtat tacgcgcgct cactggccgt cgttttacaa cgtcgtgact 4320 gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct 4380 ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg 4440 gcgaatggga cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca 4500 gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct 4560 ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt 4620 tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac 4680 gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct 4740 ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt 4800 ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac 4860 aaaaatttaa cgcgaatttt aacaaaatat taacgcttac aatttaggtg gcacttttcg 4920 gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc 4980 gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag 5040 tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt 5100 tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt 5160 gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga 5220 acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat 5280 tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga 5340 gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag 5400 tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg 5460 accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg 5520 ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt 5580 agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg 5640 gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc 5700 ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg 5760 tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac 5820 ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact 5880 gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa 5940 acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa 6000 aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg 6060 atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc 6120 gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac 6180 tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt agttaggcca 6240 ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt 6300 ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc 6360 ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg 6420 aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc 6480 cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac 6540 gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct 6600 ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc 6660 cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt 6720 tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac 6780 cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg 6840 cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca gctggcacga 6900 caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga gttagctcac 6960 tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt 7020 gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca agcgcgcaat 7080 taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc ttatgcaata 7140 ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca aggagagaaa 7200 aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt attaggaagg 7260 caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg cagagatatt 7320 gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca gatctgagcc 7380 tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga 7440 gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaga 7500 cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac ttgaaagcga 7560 aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg cgcacggcaa 7620 gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga ggctagaagg 7680 agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg cgatgggaaa 7740 aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata gtatgggcaa 7800 gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca gaaggctgta 7860 gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa cttagatcat 7920 tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata aaagacacca 7980 aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc gcacagcaag 8040 cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag aagtgaatta 8100 tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa ggcaaagaga 8160 agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct tgggttcttg 8220 ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca ggccagacaa 8280 ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga ggcgcaacag 8340 catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat cctggctgtg 8400 gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg aaaactcatt 8460 tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga acagatttgg 8520 aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag cttaatacac 8580 tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt attggaatta 8640 gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg gtatataaaa 8700 ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc tgtactttct 8760 atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca cctcccaacc 8820 ccgaggggac ccttgcgcct tttccaaggc agccctgggt ttgcgcaggg acgcggctgc 8880 tctgggcgtg gttccgggaa acgcagcggc gccgaccctg ggtctcgcac attcttcacg 8940 tccgttcgca gcgtcacccg gatcttcgcc gctacccttg tgggcccccc ggcgacgctt 9000 cctgctccgc ccctaagtcg ggaaggttcc ttgcggttcg cggcgtgccg gacgtgacaa 9060 acggaagccg cacgtctcac tagtaccctc gcagacggac agcgccaggg agcaatggca 9120 gcgcgccgac cgcgatgggc tgtggccaat agcggctgct cagcagggcg cgccgagagc 9180 agcggccggg aaggggcggt gcgggaggcg gggtgtgggg cggtagtgtg ggccctgttc 9240 ctgcccgcgc ggtgttccgc attctgcaag cctccggagc gcacgtcggc agtcggctcc 9300 ctcgttgacc gaatcaccga cctctctccc cagggggtac ccagctgtct agagaattct 9360 agatcttgag acaaatggca gtattcatcc acaattttaa aagaaaaggg gggattgggg 9420 ggtacagtgc aggggaaaga atagtagaca taatagcaac agacatacaa actaaagaat 9480 tacaaaaaca aattacaaaa attcaaaatt ttcgggttta ttacagggac agcagagatc 9540 cactttggcg ccggctcgag gggg 9564 <210> 181 <211> 306 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 181 Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe Leu Ile 1 5 10 15 Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 20 25 30 Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 35 40 45 Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 50 55 60 Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 65 70 75 80 Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala Gln 85 90 95 Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu 100 105 110 Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser 115 120 125 Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr 130 135 140 Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr 145 150 155 160 His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln 165 170 175 Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg 180 185 190 His Leu Val His Ala Asp Phe Gly Cys Ile Ser Gly Asp Ser Leu Ile 195 200 205 Ser Leu Ala Ser Thr Gly Lys Arg Val Ser Ile Lys Asp Leu Leu Asp 210 215 220 Glu Lys Asp Phe Glu Ile Trp Ala Ile Asn Glu Gln Thr Met Lys Leu 225 230 235 240 Glu Ser Ala Lys Val Ser Arg Val Phe Cys Thr Gly Lys Lys Leu Val 245 250 255 Tyr Ile Leu Lys Thr Arg Leu Gly Arg Thr Ile Lys Ala Thr Ala Asn 260 265 270 His Arg Phe Leu Thr Ile Asp Gly Trp Lys Arg Leu Asp Glu Leu Ser 275 280 285 Leu Lys Glu His Ile Ala Leu Pro Arg Lys Leu Glu Ser Ser Ser Leu 290 295 300 Gln Leu 305 <210> 182 <211> 9234 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 182 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgagtcc cgaaatcgaa 660 aagctctctc agagcgatat atattgggac tccatcgtaa gcataacaga gacgggggtc 720 gaggaggtgt tcgatctgac agttcctggg cctcataatt tcgtagcgaa cgacatcatt 780 gtacataact ccaacaatgt cctgacggac aatggccgca taacagcggt cattgactgg 840 agcgaggcga tgttcgggga ttcccaatac gaggtcgcca acatcttctt ctggaggccg 900 tggttggctt gcctttcata cgagaccgag atcctgactg tcgagtacgg attgcttcct 960 atcggcaaaa tcgtggagaa gaggattgaa tgtaccgtct attcagtcga taataatggg 1020 aacatctaca cacagcccgt ggctcaatgg cacgacagag gagagcagga agtttttgaa 1080 tactgtctcg aggacggatc cctcatccgc gctactaaag atcataagtt tatgaccgtg 1140 gacggccaga tgctgccaat tgacgaaatt tttgaacgag agctggatct gatgagagtc 1200 gacaaccttc caaactgatt aattaagaat tcgacccagc tttcttgtac aaagtggttg 1260 gtaagcctat ccctaaccct ctcctcggtc tcgattctac gtagtaatga gctagcagtc 1320 tcgaggttaa cgaattccgc ccccccccta acgttactgg ccgaagccgc ttggaataag 1380 gccggtgtgc gcttgtctat atgttatttt ccaccatatt gccgtctttt ggcaatgtga 1440 gggcccggaa acctggccct gtcttcttga cgagcattcc taggggtctt tcccctctcg 1500 ccaaaggaat gcaaggtctg ttgaatgtcg tgaaggaagc agttcctctg gaagcttctt 1560 gaagacaaac aacgtctgta gcgacccttt gcaggcagcg gaacccccca cctggcgaca 1620 ggtgcccctg cggccaaaag ccacgtgtat aagatacacc tgcaaaggcg gcacaacccc 1680 agtgccacgt tgtgagttgg atagttgtgg aaagagtcaa atggctctcc tcaagcgtat 1740 tcaacaaggg gctgaaggat gcccagaagg taccccattg tatgggatct gatctggggc 1800 ctcggtgcac atgctttaca tgtgtttagt cgaggttaaa aaaacgtcta ggccccccga 1860 accacgggga cgtggttttc ctttgaaaaa cacgataata ccatggtgag caagggcgag 1920 gagctgttca ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac 1980 aagttcagcg tgtccggcga gggcgagggc gatgccacct acggcaagct gaccctgaag 2040 ttcatctgca ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac caccctgacc 2100 tacggcgtgc agtgcttcag ccgctacccc gaccacatga agcagcacga cttcttcaag 2160 tccgccatgc ccgaaggcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac 2220 tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg 2280 aagggcatcg acttcaagga ggacggcaac atcctggggc acaagctgga gtacaactac 2340 aacagccaca acgtctatat catggccgac aagcagaaga acggcatcaa ggtgaacttc 2400 aagatccgcc acaacatcga ggacggcagc gtgcagctcg ccgaccacta ccagcagaac 2460 acccccatcg gcgacggccc cgtgctgctg cccgacaacc actacctgag cacccagtcc 2520 gccctgagca aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc 2580 gccgccggga tcactctcgg catggacgag ctgtacaagt aacaccggtg gcgcgttaag 2640 tcgacaatca acctctggat tacaaaattt gtgaaagatt gactggtatt cttaactatg 2700 ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat gctattgctt 2760 cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct ctttatgagg 2820 agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc 2880 ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc gctttccccc 2940 tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc 3000 ggctgttggg cactgacaat tccgtggtgt tgtcggggaa atcatcgtcc tttccttggc 3060 tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac gtcccttcgg 3120 ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc 3180 gtcttcgcct tcgccctcag acgagtcgga tctccctttg ggccgcctcc ccgcgtcgac 3240 tttaagacca atgacttaca aggcagctgt agatcttagc cactttttaa aagaaaaggg 3300 gggactggaa gggctaattc actcccaacg aagacaagat ctgctttttg cttgtactgg 3360 gtctctctgg ttagaccaga tctgagcctg ggagctctct ggctaactag ggaacccact 3420 gcttaagcct caataaagct tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg 3480 tgactctggt aactagagat ccctcagacc cttttagtca gtgtggaaaa tctctagcag 3540 tacgtatagt agttcatgtc atcttattat tcagtattta taacttgcaa agaaatgaat 3600 atcagagagt gagaggaact tgtttattgc agcttataat ggttacaaat aaagcaatag 3660 catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa 3720 actcatcaat gtatcttatc atgtctggct ctagctatcc cgcccctaac tccgcccatc 3780 ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt 3840 atttatgcag aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc 3900 ttttttggag gcctagggac gtacccaatt cgccctatag tgagtcgtat tacgcgcgct 3960 cactggccgt cgttttacaa cgtcgtgact gggaaaaccc tggcgttacc caacttaatc 4020 gccttgcagc acatccccct ttcgccagct ggcgtaatag cgaagaggcc cgcaccgatc 4080 gcccttccca acagttgcgc agcctgaatg gcgaatggga cgcgccctgt agcggcgcat 4140 taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag 4200 cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc 4260 aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc 4320 ccaaaaaact tgattagggt gatggttcac gtagtgggcc atcgccctga tagacggttt 4380 ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa 4440 caacactcaa ccctatctcg gtctattctt ttgatttata agggattttg ccgatttcgg 4500 cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat 4560 taacgcttac aatttaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt 4620 atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct 4680 tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc 4740 cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa 4800 agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg 4860 taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt 4920 tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg 4980 catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac 5040 ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc 5100 ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa 5160 catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc 5220 aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt 5280 aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga 5340 taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa 5400 atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa 5460 gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa 5520 tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt 5580 ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt 5640 gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg 5700 agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt 5760 aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca 5820 agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac 5880 tgttcttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac 5940 atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct 6000 taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg 6060 gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca 6120 gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt 6180 aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta 6240 tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc 6300 gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc 6360 cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa 6420 ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag 6480 cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg 6540 ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag cgggcagtga 6600 gcgcaacgca attaatgtga gttagctcac tcattaggca ccccaggctt tacactttat 6660 gcttccggct cgtatgttgt gtggaattgt gagcggataa caatttcaca caggaaacag 6720 ctatgaccat gattacgcca agcgcgcaat taaccctcac taaagggaac aaaagctgga 6780 gctgcaagct taatgtagtc ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg 6840 agttagcaac atgccttaca aggagagaaa aagcaccgtg catgccgatt ggtggaagta 6900 aggtggtacg atcgtgcctt attaggaagg caacagacgg gtctgacatg gattggacga 6960 accactgaat tgccgcattg cagagatatt gtatttaagt gcctagctcg atacataaac 7020 gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca 7080 ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg 7140 tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc 7200 agtggcgccc gaacagggac ttgaaagcga aagggaaacc agaggagctc tctcgacgca 7260 ggactcggct tgctgaagcg cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc 7320 caaaaatttt gactagcgga ggctagaagg agagagatgg gtgcgagagc gtcagtatta 7380 agcgggggag aattagatcg cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa 7440 aatataaatt aaaacatata gtatgggcaa gcagggagct agaacgattc gcagttaatc 7500 ctggcctgtt agaaacatca gaaggctgta gacaaatact gggacagcta caaccatccc 7560 ttcagacagg atcagaagaa cttagatcat tatataatac agtagcaacc ctctattgtg 7620 tgcatcaaag gatagagata aaagacacca aggaagcttt agacaagata gaggaagagc 7680 aaaacaaaag taagaccacc gcacagcaag cggccgctga tcttcagacc tggaggagga 7740 gatatgaggg acaattggag aagtgaatta tataaatata aagtagtaaa aattgaacca 7800 ttaggagtag cacccaccaa ggcaaagaga agagtggtgc agagagaaaa aagagcagtg 7860 ggaataggag ctttgttcct tgggttcttg ggagcagcag gaagcactat gggcgcagcg 7920 tcaatgacgc tgacggtaca ggccagacaa ttattgtctg gtatagtgca gcagcagaac 7980 aatttgctga gggctattga ggcgcaacag catctgttgc aactcacagt ctggggcatc 8040 aagcagctcc aggcaagaat cctggctgtg gaaagatacc taaaggatca acagctcctg 8100 gggatttggg gttgctctgg aaaactcatt tgcaccactg ctgtgccttg gaatgctagt 8160 tggagtaata aatctctgga acagatttgg aatcacacga cctggatgga gtgggacaga 8220 gaaattaaca attacacaag cttaatacac tccttaattg aagaatcgca aaaccagcaa 8280 gaaaagaatg aacaagaatt attggaatta gataaatggg caagtttgtg gaattggttt 8340 aacataacaa attggctgtg gtatataaaa ttattcataa tgatagtagg aggcttggta 8400 ggtttaagaa tagtttttgc tgtactttct atagtgaata gagttaggca gggatattca 8460 ccattatcgt ttcagaccca cctcccaacc ccgaggggac ccttgcgcct tttccaaggc 8520 agccctgggt ttgcgcaggg acgcggctgc tctgggcgtg gttccgggaa acgcagcggc 8580 gccgaccctg ggtctcgcac attcttcacg tccgttcgca gcgtcacccg gatcttcgcc 8640 gctacccttg tgggcccccc ggcgacgctt cctgctccgc ccctaagtcg ggaaggttcc 8700 ttgcggttcg cggcgtgccg gacgtgacaa acggaagccg cacgtctcac tagtaccctc 8760 gcagacggac agcgccaggg agcaatggca gcgcgccgac cgcgatgggc tgtggccaat 8820 agcggctgct cagcagggcg cgccgagagc agcggccggg aaggggcggt gcgggaggcg 8880 gggtgtgggg cggtagtgtg ggccctgttc ctgcccgcgc ggtgttccgc attctgcaag 8940 cctccggagc gcacgtcggc agtcggctcc ctcgttgacc gaatcaccga cctctctccc 9000 cagggggtac ccagctgtct agagaattct agatcttgag acaaatggca gtattcatcc 9060 acaattttaa aagaaaaggg gggattgggg ggtacagtgc aggggaaaga atagtagaca 9120 taatagcaac agacatacaa actaaagaat tacaaaaaca aattacaaaa attcaaaatt 9180 ttcgggttta ttacagggac agcagagatc cactttggcg ccggctcgag gggg 9234 <210> 183 <211> 191 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 183 Met Ser Pro Glu Ile Glu Lys Leu Ser Gln Ser Asp Ile Tyr Trp Asp 1 5 10 15 Ser Ile Val Ser Ile Thr Glu Thr Gly Val Glu Glu Val Phe Asp Leu 20 25 30 Thr Val Pro Gly Pro His Asn Phe Val Ala Asn Asp Ile Ile Val His 35 40 45 Asn Ser Asn Asn Val Leu Thr Asp Asn Gly Arg Ile Thr Ala Val Ile 50 55 60 Asp Trp Ser Glu Ala Met Phe Gly Asp Ser Gln Tyr Glu Val Ala Asn 65 70 75 80 Ile Phe Phe Trp Arg Pro Trp Leu Ala Cys Leu Ser Tyr Glu Thr Glu 85 90 95 Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu 100 105 110 Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile 115 120 125 Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val 130 135 140 Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp 145 150 155 160 His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile 165 170 175 Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn 180 185 190 <210> 184 <211> 9390 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 184 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgagtcc cgaaatcgaa 660 aagctctctc agagcgatat atattgggac tccatcgtaa gcataacaga gacgggggtc 720 gaggaggtgt tcgatctgac agttcctggg cctcataatt tcgtagcgaa cgacatcatt 780 gtacataact ccaacaatgt cctgacggac aatggccgca taacagcggt cattgactgg 840 agcgaggcga tgttcgggga ttcccaatac gaggtcgcca acatcttctt ctggaggccg 900 tggttggctt gtatggagca gcagacgcgc tacttcgagc ggaggcatcc ggagcttgca 960 ggatcgccgc ggctccgggc gtatatgctc cgcattggtc ttgaccaact ctatcagagc 1020 ttggttgacg gcaatttcga tgatgcagct tgggcgcagg gtcgatgcct ttcatacgag 1080 accgagatcc tgactgtcga gtacggattg cttcctatcg gcaaaatcgt ggagaagagg 1140 attgaatgta ccgtctattc agtcgataat aatgggaaca tctacacaca gcccgtggct 1200 caatggcacg acagaggaga gcaggaagtt tttgaatact gtctcgagga cggatccctc 1260 atccgcgcta ctaaagatca taagtttatg accgtggacg gccagatgct gccaattgac 1320 gaaatttttg aacgagagct ggatctgatg agagtcgaca accttccaaa ctgattaatt 1380 aagaattcga cccagctttc ttgtacaaag tggttggtaa gcctatccct aaccctctcc 1440 tcggtctcga ttctacgtag taatgagcta gcagtctcga ggttaacgaa ttccgccccc 1500 cccctaacgt tactggccga agccgcttgg aataaggccg gtgtgcgctt gtctatatgt 1560 tattttccac catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct 1620 tcttgacgag cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga 1680 atgtcgtgaa ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga 1740 ccctttgcag gcagcggaac cccccacctg gcgacaggtg cccctgcggc caaaagccac 1800 gtgtataaga tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag 1860 ttgtggaaag agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc 1920 agaaggtacc ccattgtatg ggatctgatc tggggcctcg gtgcacatgc tttacatgtg 1980 tttagtcgag gttaaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt 2040 gaaaaacacg ataataccat ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc 2100 atcctggtcg agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc 2160 gagggcgatg ccacctacgg caagctgacc ctgaagttca tctgcaccac cggcaagctg 2220 cccgtgccct ggcccaccct cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc 2280 taccccgacc acatgaagca gcacgacttc ttcaagtccg ccatgcccga aggctacgtc 2340 caggagcgca ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag 2400 ttcgagggcg acaccctggt gaaccgcatc gagctgaagg gcatcgactt caaggaggac 2460 ggcaacatcc tggggcacaa gctggagtac aactacaaca gccacaacgt ctatatcatg 2520 gccgacaagc agaagaacgg catcaaggtg aacttcaaga tccgccacaa catcgaggac 2580 ggcagcgtgc agctcgccga ccactaccag cagaacaccc ccatcggcga cggccccgtg 2640 ctgctgcccg acaaccacta cctgagcacc cagtccgccc tgagcaaaga ccccaacgag 2700 aagcgcgatc acatggtcct gctggagttc gtgaccgccg ccgggatcac tctcggcatg 2760 gacgagctgt acaagtaaca ccggtggcgc gttaagtcga caatcaacct ctggattaca 2820 aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat 2880 acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct 2940 ccttgtataa atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac 3000 gtggcgtggt gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca 3060 cctgtcagct cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca 3120 tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg 3180 tggtgttgtc ggggaaatca tcgtcctttc cttggctgct cgcctgtgtt gccacctgga 3240 ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt 3300 cccgcggcct gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga 3360 gtcggatctc cctttgggcc gcctccccgc gtcgacttta agaccaatga cttacaaggc 3420 agctgtagat cttagccact ttttaaaaga aaagggggga ctggaagggc taattcactc 3480 ccaacgaaga caagatctgc tttttgcttg tactgggtct ctctggttag accagatctg 3540 agcctgggag ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc 3600 ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac tctggtaact agagatccct 3660 cagacccttt tagtcagtgt ggaaaatctc tagcagtacg tatagtagtt catgtcatct 3720 tattattcag tatttataac ttgcaaagaa atgaatatca gagagtgaga ggaacttgtt 3780 tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc 3840 atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt 3900 ctggctctag ctatcccgcc cctaactccg cccatcccgc ccctaactcc gcccagttcc 3960 gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc cgaggccgcc 4020 tcggcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct agggacgtac 4080 ccaattcgcc ctatagtgag tcgtattacg cgcgctcact ggccgtcgtt ttacaacgtc 4140 gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg 4200 ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc 4260 tgaatggcga atgggacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta 4320 cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc 4380 cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt 4440 tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg 4500 gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca 4560 cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct 4620 attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga 4680 tttaacaaaa atttaacgcg aattttaaca aaatattaac gcttacaatt taggtggcac 4740 ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat 4800 gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag 4860 tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc 4920 tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc 4980 acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc 5040 cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc 5100 ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt 5160 ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt 5220 atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat 5280 cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct 5340 tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat 5400 gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc 5460 ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg 5520 ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc 5580 tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta 5640 cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc 5700 ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga 5760 tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat 5820 gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat 5880 caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa 5940 accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa 6000 ggtaactggc ttcagcagag cgcagatacc aaatactgtt cttctagtgt agccgtagtt 6060 aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt 6120 accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata 6180 gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt 6240 ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac 6300 gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga 6360 gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg 6420 ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa 6480 aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat 6540 gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc 6600 tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga 6660 agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg 6720 gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta 6780 gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta tgttgtgtgg 6840 aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt acgccaagcg 6900 cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagcttaat gtagtcttat 6960 gcaatactct tgtagtcttg caacatggta acgatgagtt agcaacatgc cttacaagga 7020 gagaaaaagc accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg tgccttatta 7080 ggaaggcaac agacgggtct gacatggatt ggacgaacca ctgaattgcc gcattgcaga 7140 gatattgtat ttaagtgcct agctcgatac ataaacgggt ctctctggtt agaccagatc 7200 tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg 7260 ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc 7320 ctcagaccct tttagtcagt gtggaaaatc tctagcagtg gcgcccgaac agggacttga 7380 aagcgaaagg gaaaccagag gagctctctc gacgcaggac tcggcttgct gaagcgcgca 7440 cggcaagagg cgaggggcgg cgactggtga gtacgccaaa aattttgact agcggaggct 7500 agaaggagag agatgggtgc gagagcgtca gtattaagcg ggggagaatt agatcgcgat 7560 gggaaaaaat tcggttaagg ccagggggaa agaaaaaata taaattaaaa catatagtat 7620 gggcaagcag ggagctagaa cgattcgcag ttaatcctgg cctgttagaa acatcagaag 7680 gctgtagaca aatactggga cagctacaac catcccttca gacaggatca gaagaactta 7740 gatcattata taatacagta gcaaccctct attgtgtgca tcaaaggata gagataaaag 7800 acaccaagga agctttagac aagatagagg aagagcaaaa caaaagtaag accaccgcac 7860 agcaagcggc cgctgatctt cagacctgga ggaggagata tgagggacaa ttggagaagt 7920 gaattatata aatataaagt agtaaaaatt gaaccattag gagtagcacc caccaaggca 7980 aagagaagag tggtgcagag agaaaaaaga gcagtgggaa taggagcttt gttccttggg 8040 ttcttgggag cagcaggaag cactatgggc gcagcgtcaa tgacgctgac ggtacaggcc 8100 agacaattat tgtctggtat agtgcagcag cagaacaatt tgctgagggc tattgaggcg 8160 caacagcatc tgttgcaact cacagtctgg ggcatcaagc agctccaggc aagaatcctg 8220 gctgtggaaa gatacctaaa ggatcaacag ctcctgggga tttggggttg ctctggaaaa 8280 ctcatttgca ccactgctgt gccttggaat gctagttgga gtaataaatc tctggaacag 8340 atttggaatc acacgacctg gatggagtgg gacagagaaa ttaacaatta cacaagctta 8400 atacactcct taattgaaga atcgcaaaac cagcaagaaa agaatgaaca agaattattg 8460 gaattagata aatgggcaag tttgtggaat tggtttaaca taacaaattg gctgtggtat 8520 ataaaattat tcataatgat agtaggaggc ttggtaggtt taagaatagt ttttgctgta 8580 ctttctatag tgaatagagt taggcaggga tattcaccat tatcgtttca gacccacctc 8640 ccaaccccga ggggaccctt gcgccttttc caaggcagcc ctgggtttgc gcagggacgc 8700 ggctgctctg ggcgtggttc cgggaaacgc agcggcgccg accctgggtc tcgcacattc 8760 ttcacgtccg ttcgcagcgt cacccggatc ttcgccgcta cccttgtggg ccccccggcg 8820 acgcttcctg ctccgcccct aagtcgggaa ggttccttgc ggttcgcggc gtgccggacg 8880 tgacaaacgg aagccgcacg tctcactagt accctcgcag acggacagcg ccagggagca 8940 atggcagcgc gccgaccgcg atgggctgtg gccaatagcg gctgctcagc agggcgcgcc 9000 gagagcagcg gccgggaagg ggcggtgcgg gaggcggggt gtggggcggt agtgtgggcc 9060 ctgttcctgc ccgcgcggtg ttccgcattc tgcaagcctc cggagcgcac gtcggcagtc 9120 ggctccctcg ttgaccgaat caccgacctc tctccccagg gggtacccag ctgtctagag 9180 aattctagat cttgagacaa atggcagtat tcatccacaa ttttaaaaga aaagggggga 9240 ttggggggta cagtgcaggg gaaagaatag tagacataat agcaacagac atacaaacta 9300 aagaattaca aaaacaaatt acaaaaattc aaaattttcg ggtttattac agggacagca 9360 gagatccact ttggcgccgg ctcgaggggg 9390 <210> 185 <211> 243 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 185 Met Ser Pro Glu Ile Glu Lys Leu Ser Gln Ser Asp Ile Tyr Trp Asp 1 5 10 15 Ser Ile Val Ser Ile Thr Glu Thr Gly Val Glu Glu Val Phe Asp Leu 20 25 30 Thr Val Pro Gly Pro His Asn Phe Val Ala Asn Asp Ile Ile Val His 35 40 45 Asn Ser Asn Asn Val Leu Thr Asp Asn Gly Arg Ile Thr Ala Val Ile 50 55 60 Asp Trp Ser Glu Ala Met Phe Gly Asp Ser Gln Tyr Glu Val Ala Asn 65 70 75 80 Ile Phe Phe Trp Arg Pro Trp Leu Ala Cys Met Glu Gln Gln Thr Arg 85 90 95 Tyr Phe Glu Arg Arg His Pro Glu Leu Ala Gly Ser Pro Arg Leu Arg 100 105 110 Ala Tyr Met Leu Arg Ile Gly Leu Asp Gln Leu Tyr Gln Ser Leu Val 115 120 125 Asp Gly Asn Phe Asp Asp Ala Ala Trp Ala Gln Gly Arg Cys Leu Ser 130 135 140 Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly 145 150 155 160 Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn 165 170 175 Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly 180 185 190 Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg 195 200 205 Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro 210 215 220 Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn 225 230 235 240 Leu Pro Asn <210> 186 <211> 10263 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 186 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagctgaacg agaaacgtaa aatgatataa atatcaatat attaaattag 660 attttgcata aaaaacagac tacataatac tgtaaaacac aacatatcca gtcactatgg 720 cggccgcatt aggcacccca ggctttacac tttatgcttc cggctcgtat aatgtgtgga 780 ttttgagtta ggatccgtcg agattttcag gagctaagga agctaaaatg gagaaaaaaa 840 tcactggata taccaccgtt gatatatccc aatggcatcg taaagaacat tttgaggcat 900 ttcagtcagt tgctcaatgt acctataacc agaccgttca gctggatatt acggcctttt 960 taaagaccgt aaagaaaaat aagcacaagt tttatccggc ctttattcac attcttgccc 1020 gcctgatgaa tgctcatccg gaattccgta tggcaatgaa agacggtgag ctggtgatat 1080 gggatagtgt tcacccttgt tacaccgttt tccatgagca aactgaaacg ttttcatcgc 1140 tctggagtga ataccacgac gatttccggc agtttctaca catatattcg caagatgtgg 1200 cgtgttacgg tgaaaacctg gcctatttcc ctaaagggtt tattgagaat atgtttttcg 1260 tctcagccaa tccctgggtg agtttcacca gttttgattt aaacgtggcc aatatggaca 1320 acttcttcgc ccccgttttc accatgggca aatattatac gcaaggcgac aaggtgctga 1380 tgccgctggc gattcaggtt catcatgccg tttgtgatgg cttccatgtc ggcagaatgc 1440 ttaatgaatt acaacagtac tgcgatgagt ggcagggcgg ggcgtaaaga tctggatccg 1500 gcttactaaa agccagataa cagtatgcgt atttgcgcgc tgatttttgc ggtataagaa 1560 tatatactga tatgtatacc cgaagtatgt caaaaagagg tatgctatga agcagcgtat 1620 tacagtgaca gttgacagcg acagctatca gttgctcaag gcatatatga tgtcaatatc 1680 tccggtctgg taagcacaac catgcagaat gaagcccgtc gtctgcgtgc cgaacgctgg 1740 aaagcggaaa atcaggaagg gatggctgag gtcgcccggt ttattgaaat gaacggctct 1800 tttgctgacg agaacagggg ctggtgaaat gcagtttaag gtttacacct ataaaagaga 1860 gagccgttat cgtctgtttg tggatgtaca gagtgatatt attgacacgc ccgggcgacg 1920 gatggtgatc cccctggcca gtgcacgtct gctgtcagat aaagtctccc gtgaacttta 1980 cccggtggtg catatcgggg atgaaagctg gcgcatgatg accaccgata tggccagtgt 2040 gccggtctcc gttatcgggg aagaagtggc tgatctcagc caccgcgaaa atgacatcaa 2100 aaacgccatt aacctgatgt tctggggaat ataaatgtca ggctccctta tacacagcca 2160 gtctgcaggt cgaccatagt gactggatat gttgtgtttt acagtattat gtagtctgtt 2220 ttttatgcaa aatctaattt aatatattga tatttatatc attttacgtt tctcgttcag 2280 ctttcttgta caaagtggtt ggtaagccta tccctaaccc tctcctcggt ctcgattcta 2340 cgtagtaatg agctagcagt ctcgaggtta acgaattccg ccccccccct aacgttactg 2400 gccgaagccg cttggaataa ggccggtgtg cgcttgtcta tatgttattt tccaccatat 2460 tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc 2520 ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag 2580 cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc 2640 ggaacccccc acctggcgac aggtgcccct gcggccaaaa gccacgtgta taagatacac 2700 ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca 2760 aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt 2820 gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa 2880 aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgataat 2940 accatggcca tgagcgagct gattaaggag aacatgcaca tgaagctgta catggagggc 3000 accgtggaca accatcactt caagtgcaca tccgagggcg aaggcaagcc ctacgagggc 3060 acccagacca tgagaatcaa ggtggtcgag ggcggccctc tccccttcgc cttcgacatc 3120 ctggctacta gcttcctcta cggcagcaag accttcatca accacaccca gggcatcccc 3180 gacttcttca agcagtcctt ccctgagggc ttcacatggg agagagtcac cacatacgaa 3240 gacgggggcg tgctgaccgc tacccaggac accagcctcc aggacggctg cctcatctac 3300 aacgtcaaga tcagaggggt gaacttcaca tccaacggcc ctgtgatgca gaagaaaaca 3360 ctcggctggg aggccttcac cgagacgctg taccccgctg acggcggcct ggaaggcaga 3420 aacgacatgg ccctgaagct cgtgggcggg agccatctga tcgcaaacat caagaccaca 3480 tatagatcca agaaacccgc taagaacctc aagatgcctg gcgtctacta tgtggactac 3540 agactggaaa gaatcaagga ggccaacaac gagacctacg tcgagcagca cgaggtggca 3600 gtggccagat actgcgacct ccctagcaaa ctggggcaca agcttaatta acaccggtgg 3660 cgcgttaagt cgacaatcaa cctctggatt acaaaatttg tgaaagattg actggtattc 3720 ttaactatgt tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg 3780 ctattgcttc ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc 3840 tttatgagga gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg 3900 acgcaacccc cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg 3960 ctttccccct ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga 4020 caggggctcg gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct 4080 ttccttggct gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg 4140 tcccttcggc cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc 4200 ctcttccgcg tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc 4260 cgcgtcgact ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa 4320 agaaaagggg ggactggaag ggctaattca ctcccaacga agacaagatc tgctttttgc 4380 ttgtactggg tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg 4440 gaacccactg cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg 4500 tctgttgtgt gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat 4560 ctctagcagt acgtatagta gttcatgtca tcttattatt cagtatttat aacttgcaaa 4620 gaaatgaata tcagagagtg agaggaactt gtttattgca gcttataatg gttacaaata 4680 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 4740 tttgtccaaa ctcatcaatg tatcttatca tgtctggctc tagctatccc gcccctaact 4800 ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta 4860 atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt ccagaagtag 4920 tgaggaggct tttttggagg cctagggacg tacccaattc gccctatagt gagtcgtatt 4980 acgcgcgctc actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc 5040 aacttaatcg ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc 5100 gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatgggac gcgccctgta 5160 gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca 5220 gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct 5280 ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc 5340 acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat 5400 agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc 5460 aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc 5520 cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta 5580 acaaaatatt aacgcttaca atttaggtgg cacttttcgg ggaaatgtgc gcggaacccc 5640 tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg 5700 ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc 5760 ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt 5820 gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct 5880 caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac 5940 ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact 6000 cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa 6060 gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga 6120 taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt 6180 tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga 6240 agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg 6300 caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat 6360 ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat 6420 tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc 6480 agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga 6540 tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc 6600 agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag 6660 gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc 6720 gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt 6780 tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt 6840 gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat 6900 accaaatact gttcttctag tgtagccgta gttaggccac cacttcaaga actctgtagc 6960 accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa 7020 gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg 7080 ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag 7140 atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag 7200 gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa 7260 cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt 7320 gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg 7380 gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc 7440 tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac 7500 cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct 7560 ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc 7620 gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt 7680 acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac 7740 aggaaacagc tatgaccatg attacgccaa gcgcgcaatt aaccctcact aaagggaaca 7800 aaagctggag ctgcaagctt aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg 7860 gtaacgatga gttagcaaca tgccttacaa ggagagaaaa agcaccgtgc atgccgattg 7920 gtggaagtaa ggtggtacga tcgtgcctta ttaggaaggc aacagacggg tctgacatgg 7980 attggacgaa ccactgaatt gccgcattgc agagatattg tatttaagtg cctagctcga 8040 tacataaacg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta 8100 gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc 8160 cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa 8220 atctctagca gtggcgcccg aacagggact tgaaagcgaa agggaaacca gaggagctct 8280 ctcgacgcag gactcggctt gctgaagcgc gcacggcaag aggcgagggg cggcgactgg 8340 tgagtacgcc aaaaattttg actagcggag gctagaagga gagagatggg tgcgagagcg 8400 tcagtattaa gcgggggaga attagatcgc gatgggaaaa aattcggtta aggccagggg 8460 gaaagaaaaa atataaatta aaacatatag tatgggcaag cagggagcta gaacgattcg 8520 cagttaatcc tggcctgtta gaaacatcag aaggctgtag acaaatactg ggacagctac 8580 aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca gtagcaaccc 8640 tctattgtgt gcatcaaagg atagagataa aagacaccaa ggaagcttta gacaagatag 8700 aggaagagca aaacaaaagt aagaccaccg cacagcaagc ggccgctgat cttcagacct 8760 ggaggaggag atatgaggga caattggaga agtgaattat ataaatataa agtagtaaaa 8820 attgaaccat taggagtagc acccaccaag gcaaagagaa gagtggtgca gagagaaaaa 8880 agagcagtgg gaataggagc tttgttcctt gggttcttgg gagcagcagg aagcactatg 8940 ggcgcagcgt caatgacgct gacggtacag gccagacaat tattgtctgg tatagtgcag 9000 cagcagaaca atttgctgag ggctattgag gcgcaacagc atctgttgca actcacagtc 9060 tggggcatca agcagctcca ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa 9120 cagctcctgg ggatttgggg ttgctctgga aaactcattt gcaccactgc tgtgccttgg 9180 aatgctagtt ggagtaataa atctctggaa cagatttgga atcacacgac ctggatggag 9240 tgggacagag aaattaacaa ttacacaagc ttaatacact ccttaattga agaatcgcaa 9300 aaccagcaag aaaagaatga acaagaatta ttggaattag ataaatgggc aagtttgtgg 9360 aattggttta acataacaaa ttggctgtgg tatataaaat tattcataat gatagtagga 9420 ggcttggtag gtttaagaat agtttttgct gtactttcta tagtgaatag agttaggcag 9480 ggatattcac cattatcgtt tcagacccac ctcccaaccc cgaggggacc cttgcgcctt 9540 ttccaaggca gccctgggtt tgcgcaggga cgcggctgct ctgggcgtgg ttccgggaaa 9600 cgcagcggcg ccgaccctgg gtctcgcaca ttcttcacgt ccgttcgcag cgtcacccgg 9660 atcttcgccg ctacccttgt gggccccccg gcgacgcttc ctgctccgcc cctaagtcgg 9720 gaaggttcct tgcggttcgc ggcgtgccgg acgtgacaaa cggaagccgc acgtctcact 9780 agtaccctcg cagacggaca gcgccaggga gcaatggcag cgcgccgacc gcgatgggct 9840 gtggccaata gcggctgctc agcagggcgc gccgagagca gcggccggga aggggcggtg 9900 cgggaggcgg ggtgtggggc ggtagtgtgg gccctgttcc tgcccgcgcg gtgttccgca 9960 ttctgcaagc ctccggagcg cacgtcggca gtcggctccc tcgttgaccg aatcaccgac 10020 ctctctcccc agggggtacc cagctgtcta gagaattcta gatcttgaga caaatggcag 10080 tattcatcca caattttaaa agaaaagggg ggattggggg gtacagtgca ggggaaagaa 10140 tagtagacat aatagcaaca gacatacaaa ctaaagaatt acaaaaacaa attacaaaaa 10200 ttcaaaattt tcgggtttat tacagggaca gcagagatcc actttggcgc cggctcgagg 10260 ggg 10263 <210> 187 <211> 10275 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 187 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagctgaacg agaaacgtaa aatgatataa atatcaatat attaaattag 660 attttgcata aaaaacagac tacataatac tgtaaaacac aacatatcca gtcactatgg 720 cggccgcatt aggcacccca ggctttacac tttatgcttc cggctcgtat aatgtgtgga 780 ttttgagtta ggatccgtcg agattttcag gagctaagga agctaaaatg gagaaaaaaa 840 tcactggata taccaccgtt gatatatccc aatggcatcg taaagaacat tttgaggcat 900 ttcagtcagt tgctcaatgt acctataacc agaccgttca gctggatatt acggcctttt 960 taaagaccgt aaagaaaaat aagcacaagt tttatccggc ctttattcac attcttgccc 1020 gcctgatgaa tgctcatccg gaattccgta tggcaatgaa agacggtgag ctggtgatat 1080 gggatagtgt tcacccttgt tacaccgttt tccatgagca aactgaaacg ttttcatcgc 1140 tctggagtga ataccacgac gatttccggc agtttctaca catatattcg caagatgtgg 1200 cgtgttacgg tgaaaacctg gcctatttcc ctaaagggtt tattgagaat atgtttttcg 1260 tctcagccaa tccctgggtg agtttcacca gttttgattt aaacgtggcc aatatggaca 1320 acttcttcgc ccccgttttc accatgggca aatattatac gcaaggcgac aaggtgctga 1380 tgccgctggc gattcaggtt catcatgccg tttgtgatgg cttccatgtc ggcagaatgc 1440 ttaatgaatt acaacagtac tgcgatgagt ggcagggcgg ggcgtaaaga tctggatccg 1500 gcttactaaa agccagataa cagtatgcgt atttgcgcgc tgatttttgc ggtataagaa 1560 tatatactga tatgtatacc cgaagtatgt caaaaagagg tatgctatga agcagcgtat 1620 tacagtgaca gttgacagcg acagctatca gttgctcaag gcatatatga tgtcaatatc 1680 tccggtctgg taagcacaac catgcagaat gaagcccgtc gtctgcgtgc cgaacgctgg 1740 aaagcggaaa atcaggaagg gatggctgag gtcgcccggt ttattgaaat gaacggctct 1800 tttgctgacg agaacagggg ctggtgaaat gcagtttaag gtttacacct ataaaagaga 1860 gagccgttat cgtctgtttg tggatgtaca gagtgatatt attgacacgc ccgggcgacg 1920 gatggtgatc cccctggcca gtgcacgtct gctgtcagat aaagtctccc gtgaacttta 1980 cccggtggtg catatcgggg atgaaagctg gcgcatgatg accaccgata tggccagtgt 2040 gccggtctcc gttatcgggg aagaagtggc tgatctcagc caccgcgaaa atgacatcaa 2100 aaacgccatt aacctgatgt tctggggaat ataaatgtca ggctccctta tacacagcca 2160 gtctgcaggt cgaccatagt gactggatat gttgtgtttt acagtattat gtagtctgtt 2220 ttttatgcaa aatctaattt aatatattga tatttatatc attttacgtt tctcgttcag 2280 ctttcttgta caaagtggtt ggtaagccta tccctaaccc tctcctcggt ctcgattcta 2340 cgtagtaatg agctagcagt ctcgaggtta acgaattccg ccccccccct aacgttactg 2400 gccgaagccg cttggaataa ggccggtgtg cgcttgtcta tatgttattt tccaccatat 2460 tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc 2520 ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag 2580 cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc 2640 ggaacccccc acctggcgac aggtgcccct gcggccaaaa gccacgtgta taagatacac 2700 ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca 2760 aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt 2820 gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa 2880 aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgataat 2940 accatggtga gcaagggcga ggagctgttc accggggtgg tgcccatcct ggtcgagctg 3000 gacggcgacg taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc 3060 tacggcaagc tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc 3120 accctcgtga ccaccctgac ctacggcgtg cagtgcttca gccgctaccc cgaccacatg 3180 aagcagcacg acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc 3240 ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc 3300 ctggtgaacc gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg 3360 cacaagctgg agtacaacta caacagccac aacgtctata tcatggccga caagcagaag 3420 aacggcatca aggtgaactt caagatccgc cacaacatcg aggacggcag cgtgcagctc 3480 gccgaccact accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac 3540 cactacctga gcacccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg 3600 gtcctgctgg agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag 3660 taacaccggt ggcgcgttaa gtcgacaatc aacctctgga ttacaaaatt tgtgaaagat 3720 tgactggtat tcttaactat gttgctcctt ttacgctatg tggatacgct gctttaatgc 3780 ctttgtatca tgctattgct tcccgtatgg ctttcatttt ctcctccttg tataaatcct 3840 ggttgctgtc tctttatgag gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca 3900 ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc caccacctgt cagctccttt 3960 ccgggacttt cgctttcccc ctccctattg ccacggcgga actcatcgcc gcctgccttg 4020 cccgctgctg gacaggggct cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga 4080 aatcatcgtc ctttccttgg ctgctcgcct gtgttgccac ctggattctg cgcgggacgt 4140 ccttctgcta cgtcccttcg gccctcaatc cagcggacct tccttcccgc ggcctgctgc 4200 cggctctgcg gcctcttccg cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt 4260 gggccgcctc cccgcgtcga ctttaagacc aatgacttac aaggcagctg tagatcttag 4320 ccacttttta aaagaaaagg ggggactgga agggctaatt cactcccaac gaagacaaga 4380 tctgcttttt gcttgtactg ggtctctctg gttagaccag atctgagcct gggagctctc 4440 tggctaacta gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt 4500 agtgtgtgcc cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc 4560 agtgtggaaa atctctagca gtacgtatag tagttcatgt catcttatta ttcagtattt 4620 ataacttgca aagaaatgaa tatcagagag tgagaggaac ttgtttattg cagcttataa 4680 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 4740 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctggc tctagctatc 4800 ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc 4860 catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc ctctgagcta 4920 ttccagaagt agtgaggagg cttttttgga ggcctaggga cgtacccaat tcgccctata 4980 gtgagtcgta ttacgcgcgc tcactggccg tcgttttaca acgtcgtgac tgggaaaacc 5040 ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc tggcgtaata 5100 gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggg 5160 acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg 5220 ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca 5280 cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta 5340 gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc 5400 catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg 5460 gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat 5520 aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta 5580 acgcgaattt taacaaaata ttaacgctta caatttaggt ggcacttttc ggggaaatgt 5640 gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag 5700 acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca 5760 tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc 5820 agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat 5880 cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc 5940 aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg 6000 gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc 6060 agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat 6120 aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga 6180 gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc 6240 ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc 6300 aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt 6360 aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc 6420 tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc 6480 agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca 6540 ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca 6600 ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa aacttcattt 6660 ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta 6720 acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg 6780 agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc 6840 ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag 6900 cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc accacttcaa 6960 gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc 7020 cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc 7080 gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta 7140 caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag 7200 aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct 7260 tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga 7320 gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc 7380 ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt 7440 atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg 7500 cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcccaatacg 7560 caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg acaggtttcc 7620 cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca ctcattaggc 7680 accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg tgagcggata 7740 acaatttcac acaggaaaca gctatgacca tgattacgcc aagcgcgcaa ttaaccctca 7800 ctaaagggaa caaaagctgg agctgcaagc ttaatgtagt cttatgcaat actcttgtag 7860 tcttgcaaca tggtaacgat gagttagcaa catgccttac aaggagagaa aaagcaccgt 7920 gcatgccgat tggtggaagt aaggtggtac gatcgtgcct tattaggaag gcaacagacg 7980 ggtctgacat ggattggacg aaccactgaa ttgccgcatt gcagagatat tgtatttaag 8040 tgcctagctc gatacataaa cgggtctctc tggttagacc agatctgagc ctgggagctc 8100 tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgcttcaa 8160 gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag 8220 tcagtgtgga aaatctctag cagtggcgcc cgaacaggga cttgaaagcg aaagggaaac 8280 cagaggagct ctctcgacgc aggactcggc ttgctgaagc gcgcacggca agaggcgagg 8340 ggcggcgact ggtgagtacg ccaaaaattt tgactagcgg aggctagaag gagagagatg 8400 ggtgcgagag cgtcagtatt aagcggggga gaattagatc gcgatgggaa aaaattcggt 8460 taaggccagg gggaaagaaa aaatataaat taaaacatat agtatgggca agcagggagc 8520 tagaacgatt cgcagttaat cctggcctgt tagaaacatc agaaggctgt agacaaatac 8580 tgggacagct acaaccatcc cttcagacag gatcagaaga acttagatca ttatataata 8640 cagtagcaac cctctattgt gtgcatcaaa ggatagagat aaaagacacc aaggaagctt 8700 tagacaagat agaggaagag caaaacaaaa gtaagaccac cgcacagcaa gcggccgctg 8760 atcttcagac ctggaggagg agatatgagg gacaattgga gaagtgaatt atataaatat 8820 aaagtagtaa aaattgaacc attaggagta gcacccacca aggcaaagag aagagtggtg 8880 cagagagaaa aaagagcagt gggaatagga gctttgttcc ttgggttctt gggagcagca 8940 ggaagcacta tgggcgcagc gtcaatgacg ctgacggtac aggccagaca attattgtct 9000 ggtatagtgc agcagcagaa caatttgctg agggctattg aggcgcaaca gcatctgttg 9060 caactcacag tctggggcat caagcagctc caggcaagaa tcctggctgt ggaaagatac 9120 ctaaaggatc aacagctcct ggggatttgg ggttgctctg gaaaactcat ttgcaccact 9180 gctgtgcctt ggaatgctag ttggagtaat aaatctctgg aacagatttg gaatcacacg 9240 acctggatgg agtgggacag agaaattaac aattacacaa gcttaataca ctccttaatt 9300 gaagaatcgc aaaaccagca agaaaagaat gaacaagaat tattggaatt agataaatgg 9360 gcaagtttgt ggaattggtt taacataaca aattggctgt ggtatataaa attattcata 9420 atgatagtag gaggcttggt aggtttaaga atagtttttg ctgtactttc tatagtgaat 9480 agagttaggc agggatattc accattatcg tttcagaccc acctcccaac cccgagggga 9540 cccttgcgcc ttttccaagg cagccctggg tttgcgcagg gacgcggctg ctctgggcgt 9600 ggttccggga aacgcagcgg cgccgaccct gggtctcgca cattcttcac gtccgttcgc 9660 agcgtcaccc ggatcttcgc cgctaccctt gtgggccccc cggcgacgct tcctgctccg 9720 cccctaagtc gggaaggttc cttgcggttc gcggcgtgcc ggacgtgaca aacggaagcc 9780 gcacgtctca ctagtaccct cgcagacgga cagcgccagg gagcaatggc agcgcgccga 9840 ccgcgatggg ctgtggccaa tagcggctgc tcagcagggc gcgccgagag cagcggccgg 9900 gaaggggcgg tgcgggaggc ggggtgtggg gcggtagtgt gggccctgtt cctgcccgcg 9960 cggtgttccg cattctgcaa gcctccggag cgcacgtcgg cagtcggctc cctcgttgac 10020 cgaatcaccg acctctctcc ccagggggta cccagctgtc tagagaattc tagatcttga 10080 gacaaatggc agtattcatc cacaatttta aaagaaaagg ggggattggg gggtacagtg 10140 caggggaaag aatagtagac ataatagcaa cagacataca aactaaagaa ttacaaaaac 10200 aaattacaaa aattcaaaat tttcgggttt attacaggga cagcagagat ccactttggc 10260 gccggctcga ggggg 10275 <210> 188 <211> 10266 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 188 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagctgaacg agaaacgtaa aatgatataa atatcaatat attaaattag 660 attttgcata aaaaacagac tacataatac tgtaaaacac aacatatcca gtcactatgg 720 cggccgcatt aggcacccca ggctttacac tttatgcttc cggctcgtat aatgtgtgga 780 ttttgagtta ggatccgtcg agattttcag gagctaagga agctaaaatg gagaaaaaaa 840 tcactggata taccaccgtt gatatatccc aatggcatcg taaagaacat tttgaggcat 900 ttcagtcagt tgctcaatgt acctataacc agaccgttca gctggatatt acggcctttt 960 taaagaccgt aaagaaaaat aagcacaagt tttatccggc ctttattcac attcttgccc 1020 gcctgatgaa tgctcatccg gaattccgta tggcaatgaa agacggtgag ctggtgatat 1080 gggatagtgt tcacccttgt tacaccgttt tccatgagca aactgaaacg ttttcatcgc 1140 tctggagtga ataccacgac gatttccggc agtttctaca catatattcg caagatgtgg 1200 cgtgttacgg tgaaaacctg gcctatttcc ctaaagggtt tattgagaat atgtttttcg 1260 tctcagccaa tccctgggtg agtttcacca gttttgattt aaacgtggcc aatatggaca 1320 acttcttcgc ccccgttttc accatgggca aatattatac gcaaggcgac aaggtgctga 1380 tgccgctggc gattcaggtt catcatgccg tttgtgatgg cttccatgtc ggcagaatgc 1440 ttaatgaatt acaacagtac tgcgatgagt ggcagggcgg ggcgtaaaga tctggatccg 1500 gcttactaaa agccagataa cagtatgcgt atttgcgcgc tgatttttgc ggtataagaa 1560 tatatactga tatgtatacc cgaagtatgt caaaaagagg tatgctatga agcagcgtat 1620 tacagtgaca gttgacagcg acagctatca gttgctcaag gcatatatga tgtcaatatc 1680 tccggtctgg taagcacaac catgcagaat gaagcccgtc gtctgcgtgc cgaacgctgg 1740 aaagcggaaa atcaggaagg gatggctgag gtcgcccggt ttattgaaat gaacggctct 1800 tttgctgacg agaacagggg ctggtgaaat gcagtttaag gtttacacct ataaaagaga 1860 gagccgttat cgtctgtttg tggatgtaca gagtgatatt attgacacgc ccgggcgacg 1920 gatggtgatc cccctggcca gtgcacgtct gctgtcagat aaagtctccc gtgaacttta 1980 cccggtggtg catatcgggg atgaaagctg gcgcatgatg accaccgata tggccagtgt 2040 gccggtctcc gttatcgggg aagaagtggc tgatctcagc caccgcgaaa atgacatcaa 2100 aaacgccatt aacctgatgt tctggggaat ataaatgtca ggctccctta tacacagcca 2160 gtctgcaggt cgaccatagt gactggatat gttgtgtttt acagtattat gtagtctgtt 2220 ttttatgcaa aatctaattt aatatattga tatttatatc attttacgtt tctcgttcag 2280 ctttcttgta caaagtggtt ggtaagccta tccctaaccc tctcctcggt ctcgattcta 2340 cgtagtaatg agctagcagt ctcgaggtta acgaattccg ccccccccct aacgttactg 2400 gccgaagccg cttggaataa ggccggtgtg cgcttgtcta tatgttattt tccaccatat 2460 tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc 2520 ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag 2580 cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc 2640 ggaacccccc acctggcgac aggtgcccct gcggccaaaa gccacgtgta taagatacac 2700 ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca 2760 aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt 2820 gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa 2880 aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgataat 2940 accatggtga gcaagggcga ggaggataac atggccatca tcaaggagtt catgcgcttc 3000 aaggtgcaca tggagggctc cgtgaacggc cacgagttcg agatcgaggg cgagggcgag 3060 ggccgcccct acgagggcac ccagaccgcc aagctgaagg tgaccaaggg tggccccctg 3120 cccttcgcct gggacatcct gtcccctcag ttcatgtacg gctccaaggc ctacgtgaag 3180 caccccgccg acatccccga ctacttgaag ctgtccttcc ccgagggctt caagtgggag 3240 cgcgtgatga acttcgagga cggcggcgtg gtgaccgtga cccaggactc ctccctgcag 3300 gacggcgagt tcatctacaa ggtgaagctg cgcggcacca acttcccctc cgacggcccc 3360 gtaatgcaga agaagaccat gggctgggag gcctcctccg agcggatgta ccccgaggac 3420 ggcgccctga agggcgagat caagcagagg ctgaagctga aggacggcgg ccactacgac 3480 gctgaggtca agaccaccta caaggccaag aagcccgtgc agctgcccgg cgcctacaac 3540 gtcaacatca agttggacat cacctcccac aacgaggact acaccatcgt ggaacagtac 3600 gaacgcgccg agggccgcca ctccaccggc ggcatggacg agctgtacaa gtaacaccgg 3660 tggcgcgtta agtcgacaat caacctctgg attacaaaat ttgtgaaaga ttgactggta 3720 ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc 3780 atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt 3840 ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg 3900 ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt 3960 tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct 4020 ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt 4080 cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct 4140 acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc 4200 ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct 4260 ccccgcgtcg actttaagac caatgactta caaggcagct gtagatctta gccacttttt 4320 aaaagaaaag gggggactgg aagggctaat tcactcccaa cgaagacaag atctgctttt 4380 tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact 4440 agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc 4500 ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa 4560 aatctctagc agtacgtata gtagttcatg tcatcttatt attcagtatt tataacttgc 4620 aaagaaatga atatcagaga gtgagaggaa cttgtttatt gcagcttata atggttacaa 4680 ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg 4740 tggtttgtcc aaactcatca atgtatctta tcatgtctgg ctctagctat cccgccccta 4800 actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga 4860 ctaatttttt ttatttatgc agaggccgag gccgcctcgg cctctgagct attccagaag 4920 tagtgaggag gcttttttgg aggcctaggg acgtacccaa ttcgccctat agtgagtcgt 4980 attacgcgcg ctcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta 5040 cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg 5100 cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg gacgcgccct 5160 gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg 5220 ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg 5280 gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac 5340 ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct 5400 gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt 5460 tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta taagggattt 5520 tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt 5580 ttaacaaaat attaacgctt acaatttagg tggcactttt cggggaaatg tgcgcggaac 5640 ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc 5700 ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt 5760 cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct 5820 ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga 5880 tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag 5940 cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca 6000 actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga 6060 aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag 6120 tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc 6180 ttttttgcac aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa 6240 tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt 6300 gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg 6360 gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt 6420 tattgctgat aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg 6480 gccagatggt aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat 6540 ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact 6600 gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa 6660 aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt 6720 ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt 6780 ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg 6840 tttgccggat caagagctac caactctttt tccgaaggta actggcttca gcagagcgca 6900 gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca agaactctgt 6960 agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga 7020 taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc 7080 gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact 7140 gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga 7200 caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg 7260 aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt 7320 tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt 7380 acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga 7440 ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac 7500 gaccgagcgc agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc 7560 tctccccgcg cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa 7620 agcgggcagt gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc 7680 tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca 7740 cacaggaaac agctatgacc atgattacgc caagcgcgca attaaccctc actaaaggga 7800 acaaaagctg gagctgcaag cttaatgtag tcttatgcaa tactcttgta gtcttgcaac 7860 atggtaacga tgagttagca acatgcctta caaggagaga aaaagcaccg tgcatgccga 7920 ttggtggaag taaggtggta cgatcgtgcc ttattaggaa ggcaacagac gggtctgaca 7980 tggattggac gaaccactga attgccgcat tgcagagata ttgtatttaa gtgcctagct 8040 cgatacataa acgggtctct ctggttagac cagatctgag cctgggagct ctctggctaa 8100 ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca agtagtgtgt 8160 gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta gtcagtgtgg 8220 aaaatctcta gcagtggcgc ccgaacaggg acttgaaagc gaaagggaaa ccagaggagc 8280 tctctcgacg caggactcgg cttgctgaag cgcgcacggc aagaggcgag gggcggcgac 8340 tggtgagtac gccaaaaatt ttgactagcg gaggctagaa ggagagagat gggtgcgaga 8400 gcgtcagtat taagcggggg agaattagat cgcgatggga aaaaattcgg ttaaggccag 8460 ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag ctagaacgat 8520 tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata ctgggacagc 8580 tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat acagtagcaa 8640 ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct ttagacaaga 8700 tagaggaaga gcaaaacaaa agtaagacca ccgcacagca agcggccgct gatcttcaga 8760 cctggaggag gagatatgag ggacaattgg agaagtgaat tatataaata taaagtagta 8820 aaaattgaac cattaggagt agcacccacc aaggcaaaga gaagagtggt gcagagagaa 8880 aaaagagcag tgggaatagg agctttgttc cttgggttct tgggagcagc aggaagcact 8940 atgggcgcag cgtcaatgac gctgacggta caggccagac aattattgtc tggtatagtg 9000 cagcagcaga acaatttgct gagggctatt gaggcgcaac agcatctgtt gcaactcaca 9060 gtctggggca tcaagcagct ccaggcaaga atcctggctg tggaaagata cctaaaggat 9120 caacagctcc tggggatttg gggttgctct ggaaaactca tttgcaccac tgctgtgcct 9180 tggaatgcta gttggagtaa taaatctctg gaacagattt ggaatcacac gacctggatg 9240 gagtgggaca gagaaattaa caattacaca agcttaatac actccttaat tgaagaatcg 9300 caaaaccagc aagaaaagaa tgaacaagaa ttattggaat tagataaatg ggcaagtttg 9360 tggaattggt ttaacataac aaattggctg tggtatataa aattattcat aatgatagta 9420 ggaggcttgg taggtttaag aatagttttt gctgtacttt ctatagtgaa tagagttagg 9480 cagggatatt caccattatc gtttcagacc cacctcccaa ccccgagggg acccttgcgc 9540 cttttccaag gcagccctgg gtttgcgcag ggacgcggct gctctgggcg tggttccggg 9600 aaacgcagcg gcgccgaccc tgggtctcgc acattcttca cgtccgttcg cagcgtcacc 9660 cggatcttcg ccgctaccct tgtgggcccc ccggcgacgc ttcctgctcc gcccctaagt 9720 cgggaaggtt ccttgcggtt cgcggcgtgc cggacgtgac aaacggaagc cgcacgtctc 9780 actagtaccc tcgcagacgg acagcgccag ggagcaatgg cagcgcgccg accgcgatgg 9840 gctgtggcca atagcggctg ctcagcaggg cgcgccgaga gcagcggccg ggaaggggcg 9900 gtgcgggagg cggggtgtgg ggcggtagtg tgggccctgt tcctgcccgc gcggtgttcc 9960 gcattctgca agcctccgga gcgcacgtcg gcagtcggct ccctcgttga ccgaatcacc 10020 gacctctctc cccagggggt acccagctgt ctagagaatt ctagatcttg agacaaatgg 10080 cagtattcat ccacaatttt aaaagaaaag gggggattgg ggggtacagt gcaggggaaa 10140 gaatagtaga cataatagca acagacatac aaactaaaga attacaaaaa caaattacaa 10200 aaattcaaaa ttttcgggtt tattacaggg acagcagaga tccactttgg cgccggctcg 10260 aggggg 10266 <210> 189 <211> 9669 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 189 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaaaaagcc tgaactcacc 660 gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 720 ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc 780 ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt 840 gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaatttag cgagagcctg 900 acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa 960 ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt 1020 agccagacga gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg 1080 cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac tgtgatggac 1140 gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc tgatgctttg ggccgaggac 1200 tgccccgaag tccggcacct cgtgcacgcg gatttcggct ccaacaatgt cctgacggac 1260 aatggccgca taacagcggt cattgactgg agcgaggcga tgttcgggga ttcccaatac 1320 gaggtcgcca acatcttctt ctggaggccg tggttggctt gtatggagca gcagacgcgc 1380 tacttcgagc ggaggcatcc ggagcttgca ggatcgccgc ggctccgggc gtatatgctc 1440 cgcattggtc ttgaccaact ctatcagagc ttggttgacg gcaatttcga tgatgcagct 1500 tgggcgcagg gtcgatgcga cgcaatcgtc cgatccggag ccgggactgt cgggcgtaca 1560 caaatcgccc gcagaagcgc ggccgtctgg accgatggct gtgtagaagt actcgccgat 1620 agtggaaacc gacgccccag cactcgtccg agggcaaagg aatagttaat taagaattcg 1680 acccagcttt cttgtacaaa gtggttggta agcctatccc taaccctctc ctcggtctcg 1740 attctacgta gtaatgagct agcagtctcg aggttaacga attccgcccc ccccctaacg 1800 ttactggccg aagccgcttg gaataaggcc ggtgtgcgct tgtctatatg ttattttcca 1860 ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga 1920 gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga 1980 aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca 2040 ggcagcggaa ccccccacct ggcgacaggt gcccctgcgg ccaaaagcca cgtgtataag 2100 atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa 2160 gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac 2220 cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga 2280 ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac 2340 gataatacca tggccatgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 2400 gagggcaccg tggacaacca tcacttcaag tgcacatccg agggcgaagg caagccctac 2460 gagggcaccc agaccatgag aatcaaggtg gtcgagggcg gccctctccc cttcgccttc 2520 gacatcctgg ctactagctt cctctacggc agcaagacct tcatcaacca cacccagggc 2580 atccccgact tcttcaagca gtccttccct gagggcttca catgggagag agtcaccaca 2640 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 2700 atctacaacg tcaagatcag aggggtgaac ttcacatcca acggccctgt gatgcagaag 2760 aaaacactcg gctgggaggc cttcaccgag acgctgtacc ccgctgacgg cggcctggaa 2820 ggcagaaacg acatggccct gaagctcgtg ggcgggagcc atctgatcgc aaacatcaag 2880 accacatata gatccaagaa acccgctaag aacctcaaga tgcctggcgt ctactatgtg 2940 gactacagac tggaaagaat caaggaggcc aacaacgaga cctacgtcga gcagcacgag 3000 gtggcagtgg ccagatactg cgacctccct agcaaactgg ggcacaagct taattaacac 3060 cggtggcgcg ttaagtcgac aatcaacctc tggattacaa aatttgtgaa agattgactg 3120 gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt 3180 atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc 3240 tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt 3300 ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga 3360 ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct 3420 gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat 3480 cgtcctttcc ttggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct 3540 gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc 3600 tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg 3660 cctccccgcg tcgactttaa gaccaatgac ttacaaggca gctgtagatc ttagccactt 3720 tttaaaagaa aaggggggac tggaagggct aattcactcc caacgaagac aagatctgct 3780 ttttgcttgt actgggtctc tctggttaga ccagatctga gcctgggagc tctctggcta 3840 actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc aagtagtgtg 3900 tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt agtcagtgtg 3960 gaaaatctct agcagtacgt atagtagttc atgtcatctt attattcagt atttataact 4020 tgcaaagaaa tgaatatcag agagtgagag gaacttgttt attgcagctt ataatggtta 4080 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 4140 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggctctagc tatcccgccc 4200 ctaactccgc ccatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc 4260 tgactaattt tttttattta tgcagaggcc gaggccgcct cggcctctga gctattccag 4320 aagtagtgag gaggcttttt tggaggccta gggacgtacc caattcgccc tatagtgagt 4380 cgtattacgc gcgctcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg 4440 ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag 4500 aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgggacgcgc 4560 cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac 4620 ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg 4680 ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt 4740 tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc 4800 cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct 4860 tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga 4920 ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga 4980 attttaacaa aatattaacg cttacaattt aggtggcact tttcggggaa atgtgcgcgg 5040 aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata 5100 accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg 5160 tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac 5220 gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact 5280 ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat 5340 gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga 5400 gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac 5460 agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat 5520 gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac 5580 cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct 5640 gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac 5700 gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga 5760 ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg 5820 gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact 5880 ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac 5940 tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta 6000 actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt 6060 taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga 6120 gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc 6180 tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt 6240 ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc 6300 gcagatacca aatactgttc ttctagtgta gccgtagtta ggccaccact tcaagaactc 6360 tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg 6420 cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg 6480 gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga 6540 actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc 6600 ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg 6660 gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg 6720 atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt 6780 tttacggttc ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc 6840 tgattctgtg gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg 6900 aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc 6960 gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt ttcccgactg 7020 gaaagcgggc agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca 7080 ggctttacac tttatgcttc cggctcgtat gttgtgtgga attgtgagcg gataacaatt 7140 tcacacagga aacagctatg accatgatta cgccaagcgc gcaattaacc ctcactaaag 7200 ggaacaaaag ctggagctgc aagcttaatg tagtcttatg caatactctt gtagtcttgc 7260 aacatggtaa cgatgagtta gcaacatgcc ttacaaggag agaaaaagca ccgtgcatgc 7320 cgattggtgg aagtaaggtg gtacgatcgt gccttattag gaaggcaaca gacgggtctg 7380 acatggattg gacgaaccac tgaattgccg cattgcagag atattgtatt taagtgccta 7440 gctcgataca taaacgggtc tctctggtta gaccagatct gagcctggga gctctctggc 7500 taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg 7560 tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg 7620 tggaaaatct ctagcagtgg cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg 7680 agctctctcg acgcaggact cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc 7740 gactggtgag tacgccaaaa attttgacta gcggaggcta gaaggagaga gatgggtgcg 7800 agagcgtcag tattaagcgg gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc 7860 cagggggaaa gaaaaaatat aaattaaaac atatagtatg ggcaagcagg gagctagaac 7920 gattcgcagt taatcctggc ctgttagaaa catcagaagg ctgtagacaa atactgggac 7980 agctacaacc atcccttcag acaggatcag aagaacttag atcattatat aatacagtag 8040 caaccctcta ttgtgtgcat caaaggatag agataaaaga caccaaggaa gctttagaca 8100 agatagagga agagcaaaac aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc 8160 agacctggag gaggagatat gagggacaat tggagaagtg aattatataa atataaagta 8220 gtaaaaattg aaccattagg agtagcaccc accaaggcaa agagaagagt ggtgcagaga 8280 gaaaaaagag cagtgggaat aggagctttg ttccttgggt tcttgggagc agcaggaagc 8340 actatgggcg cagcgtcaat gacgctgacg gtacaggcca gacaattatt gtctggtata 8400 gtgcagcagc agaacaattt gctgagggct attgaggcgc aacagcatct gttgcaactc 8460 acagtctggg gcatcaagca gctccaggca agaatcctgg ctgtggaaag atacctaaag 8520 gatcaacagc tcctggggat ttggggttgc tctggaaaac tcatttgcac cactgctgtg 8580 ccttggaatg ctagttggag taataaatct ctggaacaga tttggaatca cacgacctgg 8640 atggagtggg acagagaaat taacaattac acaagcttaa tacactcctt aattgaagaa 8700 tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg aattagataa atgggcaagt 8760 ttgtggaatt ggtttaacat aacaaattgg ctgtggtata taaaattatt cataatgata 8820 gtaggaggct tggtaggttt aagaatagtt tttgctgtac tttctatagt gaatagagtt 8880 aggcagggat attcaccatt atcgtttcag acccacctcc caaccccgag gggacccttg 8940 cgccttttcc aaggcagccc tgggtttgcg cagggacgcg gctgctctgg gcgtggttcc 9000 gggaaacgca gcggcgccga ccctgggtct cgcacattct tcacgtccgt tcgcagcgtc 9060 acccggatct tcgccgctac ccttgtgggc cccccggcga cgcttcctgc tccgccccta 9120 agtcgggaag gttccttgcg gttcgcggcg tgccggacgt gacaaacgga agccgcacgt 9180 ctcactagta ccctcgcaga cggacagcgc cagggagcaa tggcagcgcg ccgaccgcga 9240 tgggctgtgg ccaatagcgg ctgctcagca gggcgcgccg agagcagcgg ccgggaaggg 9300 gcggtgcggg aggcggggtg tggggcggta gtgtgggccc tgttcctgcc cgcgcggtgt 9360 tccgcattct gcaagcctcc ggagcgcacg tcggcagtcg gctccctcgt tgaccgaatc 9420 accgacctct ctccccaggg ggtacccagc tgtctagaga attctagatc ttgagacaaa 9480 tggcagtatt catccacaat tttaaaagaa aaggggggat tggggggtac agtgcagggg 9540 aaagaatagt agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta 9600 caaaaattca aaattttcgg gtttattaca gggacagcag agatccactt tggcgccggc 9660 tcgaggggg 9669 <210> 190 <211> 9672 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 190 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaaaaagcc tgaactcacc 660 gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 720 ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc 780 ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt 840 gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaatttag cgagagcctg 900 acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa 960 ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt 1020 agccagacga gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg 1080 cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac tgtgatggac 1140 gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc tgatgctttg ggccgaggac 1200 tgccccgaag tccggcacct cgtgcacgcg gatttcggct ccaacaatgt cctgacggac 1260 aatggccgca taacagcggt cattgactgg agcgaggcga tgttcgggga ttcccaatac 1320 gaggtcgcca acatcttctt ctggaggccg tggttggctt gtatggagca gcagacgcgc 1380 tacttcgagc ggaggcatcc ggagcttgca ggatcgccgc ggctccgggc gtatatgctc 1440 cgcattggtc ttgaccaact ctatcagagc ttggttgacg gcaatttcga tgatgcagct 1500 tgggcgcagg gtcgatgcga cgcaatcgtc cgatccggag ccgggactgt cgggcgtaca 1560 caaatcgccc gcagaagcgc ggccgtctgg accgatggct gtgtagaagt actcgccgat 1620 agtggaaacc gacgccccag cactcgtccg agggcaaagg aatagttaat taagaattcg 1680 acccagcttt cttgtacaaa gtggttggta agcctatccc taaccctctc ctcggtctcg 1740 attctacgta gtaatgagct agcagtctcg aggttaacga attccgcccc ccccctaacg 1800 ttactggccg aagccgcttg gaataaggcc ggtgtgcgct tgtctatatg ttattttcca 1860 ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga 1920 gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga 1980 aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca 2040 ggcagcggaa ccccccacct ggcgacaggt gcccctgcgg ccaaaagcca cgtgtataag 2100 atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa 2160 gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac 2220 cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga 2280 ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac 2340 gataatacca tggtgagcaa gggcgaggag gataacatgg ccatcatcaa ggagttcatg 2400 cgcttcaagg tgcacatgga gggctccgtg aacggccacg agttcgagat cgagggcgag 2460 ggcgagggcc gcccctacga gggcacccag accgccaagc tgaaggtgac caagggtggc 2520 cccctgccct tcgcctggga catcctgtcc cctcagttca tgtacggctc caaggcctac 2580 gtgaagcacc ccgccgacat ccccgactac ttgaagctgt ccttccccga gggcttcaag 2640 tgggagcgcg tgatgaactt cgaggacggc ggcgtggtga ccgtgaccca ggactcctcc 2700 ctgcaggacg gcgagttcat ctacaaggtg aagctgcgcg gcaccaactt cccctccgac 2760 ggccccgtaa tgcagaagaa gaccatgggc tgggaggcct cctccgagcg gatgtacccc 2820 gaggacggcg ccctgaaggg cgagatcaag cagaggctga agctgaagga cggcggccac 2880 tacgacgctg aggtcaagac cacctacaag gccaagaagc ccgtgcagct gcccggcgcc 2940 tacaacgtca acatcaagtt ggacatcacc tcccacaacg aggactacac catcgtggaa 3000 cagtacgaac gcgccgaggg ccgccactcc accggcggca tggacgagct gtacaagtaa 3060 caccggtggc gcgttaagtc gacaatcaac ctctggatta caaaatttgt gaaagattga 3120 ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt 3180 tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt 3240 tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg 3300 tgtttgctga cgcaaccccc actggttggg gcattgccac cacctgtcag ctcctttccg 3360 ggactttcgc tttccccctc cctattgcca cggcggaact catcgccgcc tgccttgccc 3420 gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgttg tcggggaaat 3480 catcgtcctt tccttggctg ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct 3540 tctgctacgt cccttcggcc ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg 3600 ctctgcggcc tcttccgcgt cttcgccttc gccctcagac gagtcggatc tccctttggg 3660 ccgcctcccc gcgtcgactt taagaccaat gacttacaag gcagctgtag atcttagcca 3720 ctttttaaaa gaaaaggggg gactggaagg gctaattcac tcccaacgaa gacaagatct 3780 gctttttgct tgtactgggt ctctctggtt agaccagatc tgagcctggg agctctctgg 3840 ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt 3900 gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct tttagtcagt 3960 gtggaaaatc tctagcagta cgtatagtag ttcatgtcat cttattattc agtatttata 4020 acttgcaaag aaatgaatat cagagagtga gaggaacttg tttattgcag cttataatgg 4080 ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc 4140 tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggctct agctatcccg 4200 cccctaactc cgcccatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat 4260 ggctgactaa ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc 4320 cagaagtagt gaggaggctt ttttggaggc ctagggacgt acccaattcg ccctatagtg 4380 agtcgtatta cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg 4440 gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg 4500 aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg 4560 cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta 4620 cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt 4680 tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg 4740 ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat 4800 cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac 4860 tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag 4920 ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg 4980 cgaattttaa caaaatatta acgcttacaa tttaggtggc acttttcggg gaaatgtgcg 5040 cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca 5100 ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt 5160 ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga 5220 aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga 5280 actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat 5340 gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca 5400 agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt 5460 cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac 5520 catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct 5580 aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga 5640 gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac 5700 aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat 5760 agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg 5820 ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc 5880 actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc 5940 aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg 6000 gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta 6060 atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg 6120 tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga 6180 tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt 6240 ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag 6300 agcgcagata ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa 6360 ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag 6420 tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca 6480 gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac 6540 cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa 6600 ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc 6660 agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg 6720 tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc 6780 ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc 6840 ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag 6900 ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa 6960 accgcctctc cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca ggtttcccga 7020 ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt tagctcactc attaggcacc 7080 ccaggcttta cactttatgc ttccggctcg tatgttgtgt ggaattgtga gcggataaca 7140 atttcacaca ggaaacagct atgaccatga ttacgccaag cgcgcaatta accctcacta 7200 aagggaacaa aagctggagc tgcaagctta atgtagtctt atgcaatact cttgtagtct 7260 tgcaacatgg taacgatgag ttagcaacat gccttacaag gagagaaaaa gcaccgtgca 7320 tgccgattgg tggaagtaag gtggtacgat cgtgccttat taggaaggca acagacgggt 7380 ctgacatgga ttggacgaac cactgaattg ccgcattgca gagatattgt atttaagtgc 7440 ctagctcgat acataaacgg gtctctctgg ttagaccaga tctgagcctg ggagctctct 7500 ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt gcttcaagta 7560 gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc cttttagtca 7620 gtgtggaaaa tctctagcag tggcgcccga acagggactt gaaagcgaaa gggaaaccag 7680 aggagctctc tcgacgcagg actcggcttg ctgaagcgcg cacggcaaga ggcgaggggc 7740 ggcgactggt gagtacgcca aaaattttga ctagcggagg ctagaaggag agagatgggt 7800 gcgagagcgt cagtattaag cgggggagaa ttagatcgcg atgggaaaaa attcggttaa 7860 ggccaggggg aaagaaaaaa tataaattaa aacatatagt atgggcaagc agggagctag 7920 aacgattcgc agttaatcct ggcctgttag aaacatcaga aggctgtaga caaatactgg 7980 gacagctaca accatccctt cagacaggat cagaagaact tagatcatta tataatacag 8040 tagcaaccct ctattgtgtg catcaaagga tagagataaa agacaccaag gaagctttag 8100 acaagataga ggaagagcaa aacaaaagta agaccaccgc acagcaagcg gccgctgatc 8160 ttcagacctg gaggaggaga tatgagggac aattggagaa gtgaattata taaatataaa 8220 gtagtaaaaa ttgaaccatt aggagtagca cccaccaagg caaagagaag agtggtgcag 8280 agagaaaaaa gagcagtggg aataggagct ttgttccttg ggttcttggg agcagcagga 8340 agcactatgg gcgcagcgtc aatgacgctg acggtacagg ccagacaatt attgtctggt 8400 atagtgcagc agcagaacaa tttgctgagg gctattgagg cgcaacagca tctgttgcaa 8460 ctcacagtct ggggcatcaa gcagctccag gcaagaatcc tggctgtgga aagataccta 8520 aaggatcaac agctcctggg gatttggggt tgctctggaa aactcatttg caccactgct 8580 gtgccttgga atgctagttg gagtaataaa tctctggaac agatttggaa tcacacgacc 8640 tggatggagt gggacagaga aattaacaat tacacaagct taatacactc cttaattgaa 8700 gaatcgcaaa accagcaaga aaagaatgaa caagaattat tggaattaga taaatgggca 8760 agtttgtgga attggtttaa cataacaaat tggctgtggt atataaaatt attcataatg 8820 atagtaggag gcttggtagg tttaagaata gtttttgctg tactttctat agtgaataga 8880 gttaggcagg gatattcacc attatcgttt cagacccacc tcccaacccc gaggggaccc 8940 ttgcgccttt tccaaggcag ccctgggttt gcgcagggac gcggctgctc tgggcgtggt 9000 tccgggaaac gcagcggcgc cgaccctggg tctcgcacat tcttcacgtc cgttcgcagc 9060 gtcacccgga tcttcgccgc tacccttgtg ggccccccgg cgacgcttcc tgctccgccc 9120 ctaagtcggg aaggttcctt gcggttcgcg gcgtgccgga cgtgacaaac ggaagccgca 9180 cgtctcacta gtaccctcgc agacggacag cgccagggag caatggcagc gcgccgaccg 9240 cgatgggctg tggccaatag cggctgctca gcagggcgcg ccgagagcag cggccgggaa 9300 ggggcggtgc gggaggcggg gtgtggggcg gtagtgtggg ccctgttcct gcccgcgcgg 9360 tgttccgcat tctgcaagcc tccggagcgc acgtcggcag tcggctccct cgttgaccga 9420 atcaccgacc tctctcccca gggggtaccc agctgtctag agaattctag atcttgagac 9480 aaatggcagt attcatccac aattttaaaa gaaaaggggg gattgggggg tacagtgcag 9540 gggaaagaat agtagacata atagcaacag acatacaaac taaagaatta caaaaacaaa 9600 ttacaaaaat tcaaaatttt cgggtttatt acagggacag cagagatcca ctttggcgcc 9660 ggctcgaggg gg 9672 <210> 191 <211> 9243 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 191 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaccgagta caagcccacg 660 gtgcgcctcg ccacccgcga cgacgtcccc agggccgtac gcaccctcgc cgccgcgttc 720 gccgactacc ccgccacgcg ccacaccgtc gatccggacc gccacatcga gcgggtcacc 780 gagctgcaag aactcttcct cacgcgcgtc gggctcgaca tcggcaaggt gtgggtcgcg 840 gacgacggcg ccgcggtggc ggtctggacc acgccggaga gcgtcgaagc gggggcggtg 900 ttcgccgaga tcggcccgcg catggccgag ttgagcggtt cccggctggc cgcgcagcaa 960 cagatggaag gcctcctggc gccgcaccgg cccaaggagc ccgcgtggtt cctggccacc 1020 gtcggcgtct cgcccgacca ccagggcaag ggtctgggca gcgccgtcgt gctccccgga 1080 gtggaggcgg ccgagcgcgc cggggtgccc gccttcctgg agacctccgc gccccgcaac 1140 ctccccttct acgagcggct cggcttcacc gtcaccgccg acgtcgaggt gcccgaagga 1200 ccgcgcacct ggtgcatgac ccgcaagccc ggtgcctgat taattaagaa ttcgacccag 1260 ctttcttgta caaagtggtt ggtaagccta tccctaaccc tctcctcggt ctcgattcta 1320 cgtagtaatg agctagcagt ctcgaggtta acgaattccg ccccccccct aacgttactg 1380 gccgaagccg cttggaataa ggccggtgtg cgcttgtcta tatgttattt tccaccatat 1440 tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc 1500 ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag 1560 cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc 1620 ggaacccccc acctggcgac aggtgcccct gcggccaaaa gccacgtgta taagatacac 1680 ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca 1740 aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt 1800 gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa 1860 aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgataat 1920 accatggcca tgagcgagct gattaaggag aacatgcaca tgaagctgta catggagggc 1980 accgtggaca accatcactt caagtgcaca tccgagggcg aaggcaagcc ctacgagggc 2040 acccagacca tgagaatcaa ggtggtcgag ggcggccctc tccccttcgc cttcgacatc 2100 ctggctacta gcttcctcta cggcagcaag accttcatca accacaccca gggcatcccc 2160 gacttcttca agcagtcctt ccctgagggc ttcacatggg agagagtcac cacatacgaa 2220 gacgggggcg tgctgaccgc tacccaggac accagcctcc aggacggctg cctcatctac 2280 aacgtcaaga tcagaggggt gaacttcaca tccaacggcc ctgtgatgca gaagaaaaca 2340 ctcggctggg aggccttcac cgagacgctg taccccgctg acggcggcct ggaaggcaga 2400 aacgacatgg ccctgaagct cgtgggcggg agccatctga tcgcaaacat caagaccaca 2460 tatagatcca agaaacccgc taagaacctc aagatgcctg gcgtctacta tgtggactac 2520 agactggaaa gaatcaagga ggccaacaac gagacctacg tcgagcagca cgaggtggca 2580 gtggccagat actgcgacct ccctagcaaa ctggggcaca agcttaatta acaccggtgg 2640 cgcgttaagt cgacaatcaa cctctggatt acaaaatttg tgaaagattg actggtattc 2700 ttaactatgt tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg 2760 ctattgcttc ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc 2820 tttatgagga gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg 2880 acgcaacccc cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg 2940 ctttccccct ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga 3000 caggggctcg gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct 3060 ttccttggct gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg 3120 tcccttcggc cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc 3180 ctcttccgcg tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc 3240 cgcgtcgact ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa 3300 agaaaagggg ggactggaag ggctaattca ctcccaacga agacaagatc tgctttttgc 3360 ttgtactggg tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg 3420 gaacccactg cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg 3480 tctgttgtgt gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat 3540 ctctagcagt acgtatagta gttcatgtca tcttattatt cagtatttat aacttgcaaa 3600 gaaatgaata tcagagagtg agaggaactt gtttattgca gcttataatg gttacaaata 3660 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 3720 tttgtccaaa ctcatcaatg tatcttatca tgtctggctc tagctatccc gcccctaact 3780 ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta 3840 atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt ccagaagtag 3900 tgaggaggct tttttggagg cctagggacg tacccaattc gccctatagt gagtcgtatt 3960 acgcgcgctc actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc 4020 aacttaatcg ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc 4080 gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatgggac gcgccctgta 4140 gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca 4200 gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct 4260 ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc 4320 acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat 4380 agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc 4440 aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc 4500 cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta 4560 acaaaatatt aacgcttaca atttaggtgg cacttttcgg ggaaatgtgc gcggaacccc 4620 tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg 4680 ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc 4740 ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt 4800 gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct 4860 caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac 4920 ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact 4980 cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa 5040 gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga 5100 taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt 5160 tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga 5220 agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg 5280 caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat 5340 ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat 5400 tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc 5460 agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga 5520 tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc 5580 agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag 5640 gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc 5700 gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt 5760 tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt 5820 gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat 5880 accaaatact gttcttctag tgtagccgta gttaggccac cacttcaaga actctgtagc 5940 accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa 6000 gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg 6060 ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag 6120 atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag 6180 gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa 6240 cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt 6300 gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg 6360 gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc 6420 tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac 6480 cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct 6540 ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc 6600 gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt 6660 acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac 6720 aggaaacagc tatgaccatg attacgccaa gcgcgcaatt aaccctcact aaagggaaca 6780 aaagctggag ctgcaagctt aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg 6840 gtaacgatga gttagcaaca tgccttacaa ggagagaaaa agcaccgtgc atgccgattg 6900 gtggaagtaa ggtggtacga tcgtgcctta ttaggaaggc aacagacggg tctgacatgg 6960 attggacgaa ccactgaatt gccgcattgc agagatattg tatttaagtg cctagctcga 7020 tacataaacg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta 7080 gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc 7140 cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa 7200 atctctagca gtggcgcccg aacagggact tgaaagcgaa agggaaacca gaggagctct 7260 ctcgacgcag gactcggctt gctgaagcgc gcacggcaag aggcgagggg cggcgactgg 7320 tgagtacgcc aaaaattttg actagcggag gctagaagga gagagatggg tgcgagagcg 7380 tcagtattaa gcgggggaga attagatcgc gatgggaaaa aattcggtta aggccagggg 7440 gaaagaaaaa atataaatta aaacatatag tatgggcaag cagggagcta gaacgattcg 7500 cagttaatcc tggcctgtta gaaacatcag aaggctgtag acaaatactg ggacagctac 7560 aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca gtagcaaccc 7620 tctattgtgt gcatcaaagg atagagataa aagacaccaa ggaagcttta gacaagatag 7680 aggaagagca aaacaaaagt aagaccaccg cacagcaagc ggccgctgat cttcagacct 7740 ggaggaggag atatgaggga caattggaga agtgaattat ataaatataa agtagtaaaa 7800 attgaaccat taggagtagc acccaccaag gcaaagagaa gagtggtgca gagagaaaaa 7860 agagcagtgg gaataggagc tttgttcctt gggttcttgg gagcagcagg aagcactatg 7920 ggcgcagcgt caatgacgct gacggtacag gccagacaat tattgtctgg tatagtgcag 7980 cagcagaaca atttgctgag ggctattgag gcgcaacagc atctgttgca actcacagtc 8040 tggggcatca agcagctcca ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa 8100 cagctcctgg ggatttgggg ttgctctgga aaactcattt gcaccactgc tgtgccttgg 8160 aatgctagtt ggagtaataa atctctggaa cagatttgga atcacacgac ctggatggag 8220 tgggacagag aaattaacaa ttacacaagc ttaatacact ccttaattga agaatcgcaa 8280 aaccagcaag aaaagaatga acaagaatta ttggaattag ataaatgggc aagtttgtgg 8340 aattggttta acataacaaa ttggctgtgg tatataaaat tattcataat gatagtagga 8400 ggcttggtag gtttaagaat agtttttgct gtactttcta tagtgaatag agttaggcag 8460 ggatattcac cattatcgtt tcagacccac ctcccaaccc cgaggggacc cttgcgcctt 8520 ttccaaggca gccctgggtt tgcgcaggga cgcggctgct ctgggcgtgg ttccgggaaa 8580 cgcagcggcg ccgaccctgg gtctcgcaca ttcttcacgt ccgttcgcag cgtcacccgg 8640 atcttcgccg ctacccttgt gggccccccg gcgacgcttc ctgctccgcc cctaagtcgg 8700 gaaggttcct tgcggttcgc ggcgtgccgg acgtgacaaa cggaagccgc acgtctcact 8760 agtaccctcg cagacggaca gcgccaggga gcaatggcag cgcgccgacc gcgatgggct 8820 gtggccaata gcggctgctc agcagggcgc gccgagagca gcggccggga aggggcggtg 8880 cgggaggcgg ggtgtggggc ggtagtgtgg gccctgttcc tgcccgcgcg gtgttccgca 8940 ttctgcaagc ctccggagcg cacgtcggca gtcggctccc tcgttgaccg aatcaccgac 9000 ctctctcccc agggggtacc cagctgtcta gagaattcta gatcttgaga caaatggcag 9060 tattcatcca caattttaaa agaaaagggg ggattggggg gtacagtgca ggggaaagaa 9120 tagtagacat aatagcaaca gacatacaaa ctaaagaatt acaaaaacaa attacaaaaa 9180 ttcaaaattt tcgggtttat tacagggaca gcagagatcc actttggcgc cggctcgagg 9240 ggg 9243 <210> 192 <211> 9246 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 192 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaccgagta caagcccacg 660 gtgcgcctcg ccacccgcga cgacgtcccc agggccgtac gcaccctcgc cgccgcgttc 720 gccgactacc ccgccacgcg ccacaccgtc gatccggacc gccacatcga gcgggtcacc 780 gagctgcaag aactcttcct cacgcgcgtc gggctcgaca tcggcaaggt gtgggtcgcg 840 gacgacggcg ccgcggtggc ggtctggacc acgccggaga gcgtcgaagc gggggcggtg 900 ttcgccgaga tcggcccgcg catggccgag ttgagcggtt cccggctggc cgcgcagcaa 960 cagatggaag gcctcctggc gccgcaccgg cccaaggagc ccgcgtggtt cctggccacc 1020 gtcggcgtct cgcccgacca ccagggcaag ggtctgggca gcgccgtcgt gctccccgga 1080 gtggaggcgg ccgagcgcgc cggggtgccc gccttcctgg agacctccgc gccccgcaac 1140 ctccccttct acgagcggct cggcttcacc gtcaccgccg acgtcgaggt gcccgaagga 1200 ccgcgcacct ggtgcatgac ccgcaagccc ggtgcctgat taattaagaa ttcgacccag 1260 ctttcttgta caaagtggtt ggtaagccta tccctaaccc tctcctcggt ctcgattcta 1320 cgtagtaatg agctagcagt ctcgaggtta acgaattccg ccccccccct aacgttactg 1380 gccgaagccg cttggaataa ggccggtgtg cgcttgtcta tatgttattt tccaccatat 1440 tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc 1500 ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag 1560 cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc 1620 ggaacccccc acctggcgac aggtgcccct gcggccaaaa gccacgtgta taagatacac 1680 ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca 1740 aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt 1800 gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa 1860 aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgataat 1920 accatggtga gcaagggcga ggaggataac atggccatca tcaaggagtt catgcgcttc 1980 aaggtgcaca tggagggctc cgtgaacggc cacgagttcg agatcgaggg cgagggcgag 2040 ggccgcccct acgagggcac ccagaccgcc aagctgaagg tgaccaaggg tggccccctg 2100 cccttcgcct gggacatcct gtcccctcag ttcatgtacg gctccaaggc ctacgtgaag 2160 caccccgccg acatccccga ctacttgaag ctgtccttcc ccgagggctt caagtgggag 2220 cgcgtgatga acttcgagga cggcggcgtg gtgaccgtga cccaggactc ctccctgcag 2280 gacggcgagt tcatctacaa ggtgaagctg cgcggcacca acttcccctc cgacggcccc 2340 gtaatgcaga agaagaccat gggctgggag gcctcctccg agcggatgta ccccgaggac 2400 ggcgccctga agggcgagat caagcagagg ctgaagctga aggacggcgg ccactacgac 2460 gctgaggtca agaccaccta caaggccaag aagcccgtgc agctgcccgg cgcctacaac 2520 gtcaacatca agttggacat cacctcccac aacgaggact acaccatcgt ggaacagtac 2580 gaacgcgccg agggccgcca ctccaccggc ggcatggacg agctgtacaa gtaacaccgg 2640 tggcgcgtta agtcgacaat caacctctgg attacaaaat ttgtgaaaga ttgactggta 2700 ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc 2760 atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt 2820 ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg 2880 ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt 2940 tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct 3000 ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt 3060 cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct 3120 acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc 3180 ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct 3240 ccccgcgtcg actttaagac caatgactta caaggcagct gtagatctta gccacttttt 3300 aaaagaaaag gggggactgg aagggctaat tcactcccaa cgaagacaag atctgctttt 3360 tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact 3420 agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc 3480 ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa 3540 aatctctagc agtacgtata gtagttcatg tcatcttatt attcagtatt tataacttgc 3600 aaagaaatga atatcagaga gtgagaggaa cttgtttatt gcagcttata atggttacaa 3660 ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg 3720 tggtttgtcc aaactcatca atgtatctta tcatgtctgg ctctagctat cccgccccta 3780 actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga 3840 ctaatttttt ttatttatgc agaggccgag gccgcctcgg cctctgagct attccagaag 3900 tagtgaggag gcttttttgg aggcctaggg acgtacccaa ttcgccctat agtgagtcgt 3960 attacgcgcg ctcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta 4020 cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg 4080 cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg gacgcgccct 4140 gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg 4200 ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg 4260 gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac 4320 ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct 4380 gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt 4440 tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta taagggattt 4500 tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt 4560 ttaacaaaat attaacgctt acaatttagg tggcactttt cggggaaatg tgcgcggaac 4620 ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc 4680 ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt 4740 cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct 4800 ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga 4860 tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag 4920 cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca 4980 actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga 5040 aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag 5100 tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc 5160 ttttttgcac aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa 5220 tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt 5280 gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg 5340 gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt 5400 tattgctgat aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg 5460 gccagatggt aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat 5520 ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact 5580 gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa 5640 aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt 5700 ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt 5760 ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg 5820 tttgccggat caagagctac caactctttt tccgaaggta actggcttca gcagagcgca 5880 gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca agaactctgt 5940 agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga 6000 taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc 6060 gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact 6120 gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga 6180 caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg 6240 aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt 6300 tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt 6360 acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga 6420 ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac 6480 gaccgagcgc agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc 6540 tctccccgcg cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa 6600 agcgggcagt gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc 6660 tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca 6720 cacaggaaac agctatgacc atgattacgc caagcgcgca attaaccctc actaaaggga 6780 acaaaagctg gagctgcaag cttaatgtag tcttatgcaa tactcttgta gtcttgcaac 6840 atggtaacga tgagttagca acatgcctta caaggagaga aaaagcaccg tgcatgccga 6900 ttggtggaag taaggtggta cgatcgtgcc ttattaggaa ggcaacagac gggtctgaca 6960 tggattggac gaaccactga attgccgcat tgcagagata ttgtatttaa gtgcctagct 7020 cgatacataa acgggtctct ctggttagac cagatctgag cctgggagct ctctggctaa 7080 ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca agtagtgtgt 7140 gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta gtcagtgtgg 7200 aaaatctcta gcagtggcgc ccgaacaggg acttgaaagc gaaagggaaa ccagaggagc 7260 tctctcgacg caggactcgg cttgctgaag cgcgcacggc aagaggcgag gggcggcgac 7320 tggtgagtac gccaaaaatt ttgactagcg gaggctagaa ggagagagat gggtgcgaga 7380 gcgtcagtat taagcggggg agaattagat cgcgatggga aaaaattcgg ttaaggccag 7440 ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag ctagaacgat 7500 tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata ctgggacagc 7560 tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat acagtagcaa 7620 ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct ttagacaaga 7680 tagaggaaga gcaaaacaaa agtaagacca ccgcacagca agcggccgct gatcttcaga 7740 cctggaggag gagatatgag ggacaattgg agaagtgaat tatataaata taaagtagta 7800 aaaattgaac cattaggagt agcacccacc aaggcaaaga gaagagtggt gcagagagaa 7860 aaaagagcag tgggaatagg agctttgttc cttgggttct tgggagcagc aggaagcact 7920 atgggcgcag cgtcaatgac gctgacggta caggccagac aattattgtc tggtatagtg 7980 cagcagcaga acaatttgct gagggctatt gaggcgcaac agcatctgtt gcaactcaca 8040 gtctggggca tcaagcagct ccaggcaaga atcctggctg tggaaagata cctaaaggat 8100 caacagctcc tggggatttg gggttgctct ggaaaactca tttgcaccac tgctgtgcct 8160 tggaatgcta gttggagtaa taaatctctg gaacagattt ggaatcacac gacctggatg 8220 gagtgggaca gagaaattaa caattacaca agcttaatac actccttaat tgaagaatcg 8280 caaaaccagc aagaaaagaa tgaacaagaa ttattggaat tagataaatg ggcaagtttg 8340 tggaattggt ttaacataac aaattggctg tggtatataa aattattcat aatgatagta 8400 ggaggcttgg taggtttaag aatagttttt gctgtacttt ctatagtgaa tagagttagg 8460 cagggatatt caccattatc gtttcagacc cacctcccaa ccccgagggg acccttgcgc 8520 cttttccaag gcagccctgg gtttgcgcag ggacgcggct gctctgggcg tggttccggg 8580 aaacgcagcg gcgccgaccc tgggtctcgc acattcttca cgtccgttcg cagcgtcacc 8640 cggatcttcg ccgctaccct tgtgggcccc ccggcgacgc ttcctgctcc gcccctaagt 8700 cgggaaggtt ccttgcggtt cgcggcgtgc cggacgtgac aaacggaagc cgcacgtctc 8760 actagtaccc tcgcagacgg acagcgccag ggagcaatgg cagcgcgccg accgcgatgg 8820 gctgtggcca atagcggctg ctcagcaggg cgcgccgaga gcagcggccg ggaaggggcg 8880 gtgcgggagg cggggtgtgg ggcggtagtg tgggccctgt tcctgcccgc gcggtgttcc 8940 gcattctgca agcctccgga gcgcacgtcg gcagtcggct ccctcgttga ccgaatcacc 9000 gacctctctc cccagggggt acccagctgt ctagagaatt ctagatcttg agacaaatgg 9060 cagtattcat ccacaatttt aaaagaaaag gggggattgg ggggtacagt gcaggggaaa 9120 gaatagtaga cataatagca acagacatac aaactaaaga attacaaaaa caaattacaa 9180 aaattcaaaa ttttcgggtt tattacaggg acagcagaga tccactttgg cgccggctcg 9240 aggggg 9246 <210> 193 <211> 9681 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 193 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaaaaagcc tgaactcacc 660 gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 720 ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc 780 ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt 840 gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaatttag cgagagcctg 900 acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa 960 ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt 1020 agccagacga gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg 1080 cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac tgtgatggac 1140 gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc tgatgctttg ggccgaggac 1200 tgccccgaag tccggcacct cgtgcacgcg gatttcggct ccaacaatgt cctgacggac 1260 aatggccgca taacagcggt cattgactgg agcgaggcga tgttcgggga ttcccaatac 1320 gaggtcgcca acatcttctt ctggaggccg tggttggctt gtatggagca gcagacgcgc 1380 tacttcgagc ggaggcatcc ggagcttgca ggatcgccgc ggctccgggc gtatatgctc 1440 cgcattggtc ttgaccaact ctatcagagc ttggttgacg gcaatttcga tgatgcagct 1500 tgggcgcagg gtcgatgcga cgcaatcgtc cgatccggag ccgggactgt cgggcgtaca 1560 caaatcgccc gcagaagcgc ggccgtctgg accgatggct gtgtagaagt actcgccgat 1620 agtggaaacc gacgccccag cactcgtccg agggcaaagg aatagttaat taagaattcg 1680 acccagcttt cttgtacaaa gtggttggta agcctatccc taaccctctc ctcggtctcg 1740 attctacgta gtaatgagct agcagtctcg aggttaacga attccgcccc ccccctaacg 1800 ttactggccg aagccgcttg gaataaggcc ggtgtgcgct tgtctatatg ttattttcca 1860 ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga 1920 gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga 1980 aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca 2040 ggcagcggaa ccccccacct ggcgacaggt gcccctgcgg ccaaaagcca cgtgtataag 2100 atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa 2160 gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac 2220 cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga 2280 ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac 2340 gataatacca tggtgagcaa gggcgaggag ctgttcaccg gggtggtgcc catcctggtc 2400 gagctggacg gcgacgtaaa cggccacaag ttcagcgtgt ccggcgaggg cgagggcgat 2460 gccacctacg gcaagctgac cctgaagttc atctgcacca ccggcaagct gcccgtgccc 2520 tggcccaccc tcgtgaccac cctgacctac ggcgtgcagt gcttcagccg ctaccccgac 2580 cacatgaagc agcacgactt cttcaagtcc gccatgcccg aaggctacgt ccaggagcgc 2640 accatcttct tcaaggacga cggcaactac aagacccgcg ccgaggtgaa gttcgagggc 2700 gacaccctgg tgaaccgcat cgagctgaag ggcatcgact tcaaggagga cggcaacatc 2760 ctggggcaca agctggagta caactacaac agccacaacg tctatatcat ggccgacaag 2820 cagaagaacg gcatcaaggt gaacttcaag atccgccaca acatcgagga cggcagcgtg 2880 cagctcgccg accactacca gcagaacacc cccatcggcg acggccccgt gctgctgccc 2940 gacaaccact acctgagcac ccagtccgcc ctgagcaaag accccaacga gaagcgcgat 3000 cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat ggacgagctg 3060 tacaagtaac accggtggcg cgttaagtcg acaatcaacc tctggattac aaaatttgtg 3120 aaagattgac tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt 3180 taatgccttt gtatcatgct attgcttccc gtatggcttt cattttctcc tccttgtata 3240 aatcctggtt gctgtctctt tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg 3300 tgtgcactgt gtttgctgac gcaaccccca ctggttgggg cattgccacc acctgtcagc 3360 tcctttccgg gactttcgct ttccccctcc ctattgccac ggcggaactc atcgccgcct 3420 gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc gtggtgttgt 3480 cggggaaatc atcgtccttt ccttggctgc tcgcctgtgt tgccacctgg attctgcgcg 3540 ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc ggaccttcct tcccgcggcc 3600 tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg ccctcagacg agtcggatct 3660 ccctttgggc cgcctccccg cgtcgacttt aagaccaatg acttacaagg cagctgtaga 3720 tcttagccac tttttaaaag aaaagggggg actggaaggg ctaattcact cccaacgaag 3780 acaagatctg ctttttgctt gtactgggtc tctctggtta gaccagatct gagcctggga 3840 gctctctggc taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct 3900 tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt 3960 ttagtcagtg tggaaaatct ctagcagtac gtatagtagt tcatgtcatc ttattattca 4020 gtatttataa cttgcaaaga aatgaatatc agagagtgag aggaacttgt ttattgcagc 4080 ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 4140 actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggctcta 4200 gctatcccgc ccctaactcc gcccatcccg cccctaactc cgcccagttc cgcccattct 4260 ccgccccatg gctgactaat tttttttatt tatgcagagg ccgaggccgc ctcggcctct 4320 gagctattcc agaagtagtg aggaggcttt tttggaggcc tagggacgta cccaattcgc 4380 cctatagtga gtcgtattac gcgcgctcac tggccgtcgt tttacaacgt cgtgactggg 4440 aaaaccctgg cgttacccaa cttaatcgcc ttgcagcaca tccccctttc gccagctggc 4500 gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg 4560 aatgggacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg 4620 tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc 4680 tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc 4740 gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta 4800 gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta 4860 atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg 4920 atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa 4980 aatttaacgc gaattttaac aaaatattaa cgcttacaat ttaggtggca cttttcgggg 5040 aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct 5100 catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat 5160 tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc 5220 tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg 5280 ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg 5340 ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga 5400 cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta 5460 ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc 5520 tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc 5580 gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg 5640 ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc 5700 aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca 5760 acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct 5820 tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat 5880 cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg 5940 gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat 6000 taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact 6060 tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat 6120 cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc 6180 ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct 6240 accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg 6300 cttcagcaga gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca 6360 cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc 6420 tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga 6480 taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac 6540 gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga 6600 agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag 6660 ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg 6720 acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag 6780 caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc 6840 tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc 6900 tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc 6960 aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag 7020 gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca 7080 ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag 7140 cggataacaa tttcacacag gaaacagcta tgaccatgat tacgccaagc gcgcaattaa 7200 ccctcactaa agggaacaaa agctggagct gcaagcttaa tgtagtctta tgcaatactc 7260 ttgtagtctt gcaacatggt aacgatgagt tagcaacatg ccttacaagg agagaaaaag 7320 caccgtgcat gccgattggt ggaagtaagg tggtacgatc gtgccttatt aggaaggcaa 7380 cagacgggtc tgacatggat tggacgaacc actgaattgc cgcattgcag agatattgta 7440 tttaagtgcc tagctcgata cataaacggg tctctctggt tagaccagat ctgagcctgg 7500 gagctctctg gctaactagg gaacccactg cttaagcctc aataaagctt gccttgagtg 7560 cttcaagtag tgtgtgcccg tctgttgtgt gactctggta actagagatc cctcagaccc 7620 ttttagtcag tgtggaaaat ctctagcagt ggcgcccgaa cagggacttg aaagcgaaag 7680 ggaaaccaga ggagctctct cgacgcagga ctcggcttgc tgaagcgcgc acggcaagag 7740 gcgaggggcg gcgactggtg agtacgccaa aaattttgac tagcggaggc tagaaggaga 7800 gagatgggtg cgagagcgtc agtattaagc gggggagaat tagatcgcga tgggaaaaaa 7860 ttcggttaag gccaggggga aagaaaaaat ataaattaaa acatatagta tgggcaagca 7920 gggagctaga acgattcgca gttaatcctg gcctgttaga aacatcagaa ggctgtagac 7980 aaatactggg acagctacaa ccatcccttc agacaggatc agaagaactt agatcattat 8040 ataatacagt agcaaccctc tattgtgtgc atcaaaggat agagataaaa gacaccaagg 8100 aagctttaga caagatagag gaagagcaaa acaaaagtaa gaccaccgca cagcaagcgg 8160 ccgctgatct tcagacctgg aggaggagat atgagggaca attggagaag tgaattatat 8220 aaatataaag tagtaaaaat tgaaccatta ggagtagcac ccaccaaggc aaagagaaga 8280 gtggtgcaga gagaaaaaag agcagtggga ataggagctt tgttccttgg gttcttggga 8340 gcagcaggaa gcactatggg cgcagcgtca atgacgctga cggtacaggc cagacaatta 8400 ttgtctggta tagtgcagca gcagaacaat ttgctgaggg ctattgaggc gcaacagcat 8460 ctgttgcaac tcacagtctg gggcatcaag cagctccagg caagaatcct ggctgtggaa 8520 agatacctaa aggatcaaca gctcctgggg atttggggtt gctctggaaa actcatttgc 8580 accactgctg tgccttggaa tgctagttgg agtaataaat ctctggaaca gatttggaat 8640 cacacgacct ggatggagtg ggacagagaa attaacaatt acacaagctt aatacactcc 8700 ttaattgaag aatcgcaaaa ccagcaagaa aagaatgaac aagaattatt ggaattagat 8760 aaatgggcaa gtttgtggaa ttggtttaac ataacaaatt ggctgtggta tataaaatta 8820 ttcataatga tagtaggagg cttggtaggt ttaagaatag tttttgctgt actttctata 8880 gtgaatagag ttaggcaggg atattcacca ttatcgtttc agacccacct cccaaccccg 8940 aggggaccct tgcgcctttt ccaaggcagc cctgggtttg cgcagggacg cggctgctct 9000 gggcgtggtt ccgggaaacg cagcggcgcc gaccctgggt ctcgcacatt cttcacgtcc 9060 gttcgcagcg tcacccggat cttcgccgct acccttgtgg gccccccggc gacgcttcct 9120 gctccgcccc taagtcggga aggttccttg cggttcgcgg cgtgccggac gtgacaaacg 9180 gaagccgcac gtctcactag taccctcgca gacggacagc gccagggagc aatggcagcg 9240 cgccgaccgc gatgggctgt ggccaatagc ggctgctcag cagggcgcgc cgagagcagc 9300 ggccgggaag gggcggtgcg ggaggcgggg tgtggggcgg tagtgtgggc cctgttcctg 9360 cccgcgcggt gttccgcatt ctgcaagcct ccggagcgca cgtcggcagt cggctccctc 9420 gttgaccgaa tcaccgacct ctctccccag ggggtaccca gctgtctaga gaattctaga 9480 tcttgagaca aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt 9540 acagtgcagg ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac 9600 aaaaacaaat tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccac 9660 tttggcgccg gctcgagggg g 9681 <210> 194 <211> 9771 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 194 ctcgaggggg cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca 60 tatatggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac 120 gacccccgcc cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact 180 ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa 240 gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg 300 cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta 360 gtcatcgcta ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg 420 tttgactcac ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg 480 caccaaaatc aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg 540 ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg 600 atcaacaagt ttgtacaaaa aagcaggctc cgaattcgcc cttgccgcca ccatgccaaa 660 aaaaaaacgc aaagtggtga gcaagggcga ggagctgttc accggggtgg tgcccatcct 720 ggtcgagctg gacggcgacg taaacggcca caagttcagc gtgtccggcg agggcgaggg 780 cgatgccacc tacggcaagc tgaccctgaa gttcatctgc accaccggca agctgcccgt 840 gccctggccc accctcgtga ccaccctgac ctacggcgtg cagtgcttca gccgctaccc 900 cgaccacatg aagcagcacg acttcttcaa gtccgccatg cccgaaggct acgtccagga 960 gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg tgaagttcga 1020 gggcgacacc ctggtgaacc gcatcgagct gaagggcatc gacttcaagg aggacggcaa 1080 catcctgggg cacaagctgg agtacaacta caacagccac aacgtctata tcatggccga 1140 caagcagaag aacggcatca aggtgaactt caagatccgc cacaacatcg aggacggcag 1200 cgtgcagctc gccgaccact accagcagaa cacccccatc ggcgacggcc ccgtgctgct 1260 gcccgacaac cactacctga gcacccagtc cgccctgagc aaagacccca acgagaagcg 1320 cgatcacatg gtcctgctgg agttcgtgac cgccgccggg atcactctcg gcatggacga 1380 gctgtacaag taaaagggcg aattcgaccc agctttcttg tacaaagtgg ttggtaagcc 1440 tatccctaac cctctcctcg gtctcgattc tacgtagtaa tgagctagca gtctcgaggt 1500 taacgaattc cgcccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt 1560 gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc 1620 ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag 1680 gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac 1740 aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc 1800 tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc 1860 acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca 1920 aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt 1980 gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg 2040 gggacgtggt tttcctttga aaaacacgat gataatatgg ccacaaccgc caccatgaaa 2100 aagcctgaac tcaccgcgac gtctgtcgag aagtttctga tcgaaaagtt cgacagcgtc 2160 tccgacctga tgcagctctc ggagggcgaa gaatctcgtg ctttcagctt cgatgtagga 2220 gggcgtggat atgtcctgcg ggtaaatagc tgcgccgatg gtttctacaa agatcgttat 2280 gtttatcggc actttgcatc ggccgcgctc ccgattccgg aagtgcttga cattggggaa 2340 tttagcgaga gcctgaccta ttgcatctcc cgccgtgcac agggtgtcac gttgcaagac 2400 ctgcctgaaa ccgaactgcc cgctgttctg cagccggtcg cggaggccat ggatgcgatc 2460 gctgcggccg atcttagcca gacgagcggg ttcggcccat tcggaccgca aggaatcggt 2520 caatacacta catggcgtga tttcatatgc gcgattgctg atccccatgt gtatcactgg 2580 caaactgtga tggacgacac cgtcagtgcg tccgtcgcgc aggctctcga tgagctgatg 2640 ctttgggccg aggactgccc cgaagtccgg cacctcgtgc acgcggattt cggctccaac 2700 aatgtcctga cggacaatgg ccgcataaca gcggtcattg actggagcga ggcgatgttc 2760 ggggattccc aatacgaggt cgccaacatc ttcttctgga ggccgtggtt ggcttgtatg 2820 gagcagcaga cgcgctactt cgagcggagg catccggagc ttgcaggatc gccgcggctc 2880 cgggcgtata tgctccgcat tggtcttgac caactctatc agagcttggt tgacggcaat 2940 ttcgatgatg cagcttgggc gcagggtcga tgcgacgcaa tcgtccgatc cggagccggg 3000 actgtcgggc gtacacaaat cgcccgcaga agcgcggccg tctggaccga tggctgtgta 3060 gaagtactcg ccgatagtgg aaaccgacgc cccagcactc gtccgagggc aaaggaatag 3120 acgcgtaccg gttagcaccg gtgtgatcag ggtcagacag ctgcctgcag gccggtggcg 3180 cgttaagtcg acaatcaacc tctggattac aaaatttgtg aaagattgac tggtattctt 3240 aactatgttg ctccttttac gctatgtgga tacgctgctt taatgccttt gtatcatgct 3300 attgcttccc gtatggcttt cattttctcc tccttgtata aatcctggtt gctgtctctt 3360 tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac 3420 gcaaccccca ctggttgggg cattgccacc acctgtcagc tcctttccgg gactttcgct 3480 ttccccctcc ctattgccac ggcggaactc atcgccgcct gccttgcccg ctgctggaca 3540 ggggctcggc tgttgggcac tgacaattcc gtggtgttgt cggggaaatc atcgtccttt 3600 ccttggctgc tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc 3660 ccttcggccc tcaatccagc ggaccttcct tcccgcggcc tgctgccggc tctgcggcct 3720 cttccgcgtc ttcgccttcg ccctcagacg agtcggatct ccctttgggc cgcctccccg 3780 cgtcgacttt aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag 3840 aaaagggggg actggaaggg ctaattcact cccaacgaag acaagatctg ctttttgctt 3900 gtactgggtc tctctggtta gaccagatct gagcctggga gctctctggc taactaggga 3960 acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc 4020 tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct 4080 ctagcagtac gtatagtagt tcatgtcatc ttattattca gtatttataa cttgcaaaga 4140 aatgaatatc agagagtgag aggaacttgt ttattgcagc ttataatggt tacaaataaa 4200 gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt 4260 tgtccaaact catcaatgta tcttatcatg tctggctcta gctatcccgc ccctaactcc 4320 gcccatcccg cccctaactc cgcccagttc cgcccattct ccgccccatg gctgactaat 4380 tttttttatt tatgcagagg ccgaggccgc ctcggcctct gagctattcc agaagtagtg 4440 aggaggcttt tttggaggcc tagggacgta cccaattcgc cctatagtga gtcgtattac 4500 gcgcgctcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg cgttacccaa 4560 cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga agaggcccgc 4620 accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatgggacgc gccctgtagc 4680 ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc 4740 gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt 4800 ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac 4860 ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc gccctgatag 4920 acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa 4980 actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg gattttgccg 5040 atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattttaac 5100 aaaatattaa cgcttacaat ttaggtggca cttttcgggg aaatgtgcgc ggaaccccta 5160 tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat 5220 aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc 5280 ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga 5340 aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca 5400 acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt 5460 ttaaagttct gctatgtggc gcggtattat cccgtattga cgccgggcaa gagcaactcg 5520 gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc 5580 atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata 5640 acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt 5700 tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag 5760 ccataccaaa cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca 5820 aactattaac tggcgaacta cttactctag cttcccggca acaattaata gactggatgg 5880 aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg 5940 ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag 6000 atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg 6060 aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag 6120 accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga 6180 tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt 6240 tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc 6300 tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc 6360 cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac 6420 caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac 6480 cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt 6540 cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct 6600 gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat 6660 acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt 6720 atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg 6780 cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt 6840 gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt 6900 tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg 6960 tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg 7020 agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc 7080 ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac tggaaagcgg 7140 gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc caggctttac 7200 actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa tttcacacag 7260 gaaacagcta tgaccatgat tacgccaagc gcgcaattaa ccctcactaa agggaacaaa 7320 agctggagct gcaagcttaa tgtagtctta tgcaatactc ttgtagtctt gcaacatggt 7380 aacgatgagt tagcaacatg ccttacaagg agagaaaaag caccgtgcat gccgattggt 7440 ggaagtaagg tggtacgatc gtgccttatt aggaaggcaa cagacgggtc tgacatggat 7500 tggacgaacc actgaattgc cgcattgcag agatattgta tttaagtgcc tagctcgata 7560 cataaacggg tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg 7620 gaacccactg cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg 7680 tctgttgtgt gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat 7740 ctctagcagt ggcgcccgaa cagggacttg aaagcgaaag ggaaaccaga ggagctctct 7800 cgacgcagga ctcggcttgc tgaagcgcgc acggcaagag gcgaggggcg gcgactggtg 7860 agtacgccaa aaattttgac tagcggaggc tagaaggaga gagatgggtg cgagagcgtc 7920 agtattaagc gggggagaat tagatcgcga tgggaaaaaa ttcggttaag gccaggggga 7980 aagaaaaaat ataaattaaa acatatagta tgggcaagca gggagctaga acgattcgca 8040 gttaatcctg gcctgttaga aacatcagaa ggctgtagac aaatactggg acagctacaa 8100 ccatcccttc agacaggatc agaagaactt agatcattat ataatacagt agcaaccctc 8160 tattgtgtgc atcaaaggat agagataaaa gacaccaagg aagctttaga caagatagag 8220 gaagagcaaa acaaaagtaa gaccaccgca cagcaagcgg ccgctgatct tcagacctgg 8280 aggaggagat atgagggaca attggagaag tgaattatat aaatataaag tagtaaaaat 8340 tgaaccatta ggagtagcac ccaccaaggc aaagagaaga gtggtgcaga gagaaaaaag 8400 agcagtggga ataggagctt tgttccttgg gttcttggga gcagcaggaa gcactatggg 8460 cgcagcgtca atgacgctga cggtacaggc cagacaatta ttgtctggta tagtgcagca 8520 gcagaacaat ttgctgaggg ctattgaggc gcaacagcat ctgttgcaac tcacagtctg 8580 gggcatcaag cagctccagg caagaatcct ggctgtggaa agatacctaa aggatcaaca 8640 gctcctgggg atttggggtt gctctggaaa actcatttgc accactgctg tgccttggaa 8700 tgctagttgg agtaataaat ctctggaaca gatttggaat cacacgacct ggatggagtg 8760 ggacagagaa attaacaatt acacaagctt aatacactcc ttaattgaag aatcgcaaaa 8820 ccagcaagaa aagaatgaac aagaattatt ggaattagat aaatgggcaa gtttgtggaa 8880 ttggtttaac ataacaaatt ggctgtggta tataaaatta ttcataatga tagtaggagg 8940 cttggtaggt ttaagaatag tttttgctgt actttctata gtgaatagag ttaggcaggg 9000 atattcacca ttatcgtttc agacccacct cccaaccccg aggggaccct tgcgcctttt 9060 ccaaggcagc cctgggtttg cgcagggacg cggctgctct gggcgtggtt ccgggaaacg 9120 cagcggcgcc gaccctgggt ctcgcacatt cttcacgtcc gttcgcagcg tcacccggat 9180 cttcgccgct acccttgtgg gccccccggc gacgcttcct gctccgcccc taagtcggga 9240 aggttccttg cggttcgcgg cgtgccggac gtgacaaacg gaagccgcac gtctcactag 9300 taccctcgca gacggacagc gccagggagc aatggcagcg cgccgaccgc gatgggctgt 9360 ggccaatagc ggctgctcag cagggcgcgc cgagagcagc ggccgggaag gggcggtgcg 9420 ggaggcgggg tgtggggcgg tagtgtgggc cctgttcctg cccgcgcggt gttccgcatt 9480 ctgcaagcct ccggagcgca cgtcggcagt cggctccctc gttgaccgaa tcaccgacct 9540 ctctccccag ggggtaccca gctgtctaga gaattctaga tcttgagaca aatggcagta 9600 ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg ggaaagaata 9660 gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat tacaaaaatt 9720 caaaattttc gggtttatta cagggacagc agagatccac tttggcgccg g 9771 <210> 195 <211> 9841 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 195 ctcgaggggg cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca 60 tatatggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac 120 gacccccgcc cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact 180 ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa 240 gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg 300 cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta 360 gtcatcgcta ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg 420 tttgactcac ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg 480 caccaaaatc aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg 540 ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg 600 atcaacaagt ttgtacaaaa aagcaggctc cgaattcacc ggtctagcgc taccggactc 660 agatctcgag ctcaagcttc gaattccacc atgggcgtgg ccgacctgat caagaagttc 720 gagagcatca gcaaggagga gggggatcca ccggtcgcca ccatggtgag caagggcgag 780 gcagtgatca aggagttcat gcggttcaag gtgcacatgg agggctccat gaacggccac 840 gagttcgaga tcgagggcga gggcgagggc cgcccctacg agggcaccca gaccgccaag 900 ctgaaggtga ccaagggtgg ccccctgccc ttctcctggg acatcctgtc ccctcagttc 960 atgtacggct ccagggcctt caccaagcac cccgccgaca tccccgacta ctataagcag 1020 tccttccccg agggcttcaa gtgggagcgc gtgatgaact tcgaggacgg cggcgccgtg 1080 accgtgaccc aggacacctc cctggaggac ggcaccctga tctacaaggt gaagctccgc 1140 ggcaccaact tccctcctga cggccccgta atgcagaaga agacaatggg ctgggaagcg 1200 tccaccgagc ggttgtaccc cgaggacggc gtgctgaagg gcgacattaa gatggccctg 1260 cgcctgaagg acggcggccg ctacctggcg gacttcaaga ccacctacaa ggccaagaag 1320 cccgtgcaga tgcccggcgc ctacaacgtc gaccgcaagt tggacatcac ctcccacaac 1380 gaggactaca ccgtggtgga acagtacgaa cgctccgagg gccgccactc caccggcggc 1440 atggacgagc tgtacaagta attaattaag aattcgaccc agctttcttg tacaaagtgg 1500 ttggtaagcc tatccctaac cctctcctcg gtctcgattc tacgtagtaa tgagctagca 1560 gtctcgaggt taacgaattc cgcccccccc cctaacgtta ctggccgaag ccgcttggaa 1620 taaggccggt gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat 1680 gtgagggccc ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct 1740 ctcgccaaag gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct 1800 tcttgaagac aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc 1860 gacaggtgcc tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa 1920 ccccagtgcc acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc 1980 gtattcaaca aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg 2040 gggcctcggt gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc 2100 ccgaaccacg gggacgtggt tttcctttga aaaacacgat gataatatgg ccacaaccgc 2160 caccatgaaa aagcctgaac tcaccgcgac gtctgtcgag aagtttctga tcgaaaagtt 2220 cgacagcgtc tccgacctga tgcagctctc ggagggcgaa gaatctcgtg ctttcagctt 2280 cgatgtagga gggcgtggat atgtcctgcg ggtaaatagc tgcgccgatg gtttctacaa 2340 agatcgttat gtttatcggc actttgcatc ggccgcgctc ccgattccgg aagtgcttga 2400 cattggggaa tttagcgaga gcctgaccta ttgcatctcc cgccgtgcac agggtgtcac 2460 gttgcaagac ctgcctgaaa ccgaactgcc cgctgttctg cagccggtcg cggaggccat 2520 ggatgcgatc gctgcggccg atcttagcca gacgagcggg ttcggcccat tcggaccgca 2580 aggaatcggt caatacacta catggcgtga tttcatatgc gcgattgctg atccccatgt 2640 gtatcactgg caaactgtga tggacgacac cgtcagtgcg tccgtcgcgc aggctctcga 2700 tgagctgatg ctttgggccg aggactgccc cgaagtccgg cacctcgtgc acgcggattt 2760 cggctccaac aatgtcctga cggacaatgg ccgcataaca gcggtcattg actggagcga 2820 ggcgatgttc ggggattccc aatacgaggt cgccaacatc ttcttctgga ggccgtggtt 2880 ggcttgtatg gagcagcaga cgcgctactt cgagcggagg catccggagc ttgcaggatc 2940 gccgcggctc cgggcgtata tgctccgcat tggtcttgac caactctatc agagcttggt 3000 tgacggcaat ttcgatgatg cagcttgggc gcagggtcga tgcgacgcaa tcgtccgatc 3060 cggagccggg actgtcgggc gtacacaaat cgcccgcaga agcgcggccg tctggaccga 3120 tggctgtgta gaagtactcg ccgatagtgg aaaccgacgc cccagcactc gtccgagggc 3180 aaaggaatag acgcgtaccg gttagcaccg gtgtgatcag ggtcagacag ctgcctgcag 3240 gccggtggcg cgttaagtcg acaatcaacc tctggattac aaaatttgtg aaagattgac 3300 tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt taatgccttt 3360 gtatcatgct attgcttccc gtatggcttt cattttctcc tccttgtata aatcctggtt 3420 gctgtctctt tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt 3480 gtttgctgac gcaaccccca ctggttgggg cattgccacc acctgtcagc tcctttccgg 3540 gactttcgct ttccccctcc ctattgccac ggcggaactc atcgccgcct gccttgcccg 3600 ctgctggaca ggggctcggc tgttgggcac tgacaattcc gtggtgttgt cggggaaatc 3660 atcgtccttt ccttggctgc tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt 3720 ctgctacgtc ccttcggccc tcaatccagc ggaccttcct tcccgcggcc tgctgccggc 3780 tctgcggcct cttccgcgtc ttcgccttcg ccctcagacg agtcggatct ccctttgggc 3840 cgcctccccg cgtcgacttt aagaccaatg acttacaagg cagctgtaga tcttagccac 3900 tttttaaaag aaaagggggg actggaaggg ctaattcact cccaacgaag acaagatctg 3960 ctttttgctt gtactgggtc tctctggtta gaccagatct gagcctggga gctctctggc 4020 taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg 4080 tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg 4140 tggaaaatct ctagcagtac gtatagtagt tcatgtcatc ttattattca gtatttataa 4200 cttgcaaaga aatgaatatc agagagtgag aggaacttgt ttattgcagc ttataatggt 4260 tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 4320 agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggctcta gctatcccgc 4380 ccctaactcc gcccatcccg cccctaactc cgcccagttc cgcccattct ccgccccatg 4440 gctgactaat tttttttatt tatgcagagg ccgaggccgc ctcggcctct gagctattcc 4500 agaagtagtg aggaggcttt tttggaggcc tagggacgta cccaattcgc cctatagtga 4560 gtcgtattac gcgcgctcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg 4620 cgttacccaa cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga 4680 agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatgggacgc 4740 gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac 4800 acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt 4860 cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc 4920 tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc 4980 gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact 5040 cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg 5100 gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc 5160 gaattttaac aaaatattaa cgcttacaat ttaggtggca cttttcgggg aaatgtgcgc 5220 ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa 5280 taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc 5340 cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa 5400 acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa 5460 ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg 5520 atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga cgccgggcaa 5580 gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc 5640 acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc 5700 atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta 5760 accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag 5820 ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc aatggcaaca 5880 acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca acaattaata 5940 gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc 6000 tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca 6060 ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca 6120 actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg 6180 taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa 6240 tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt 6300 gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat 6360 cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg 6420 gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga 6480 gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac 6540 tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt 6600 ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag 6660 cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc 6720 gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag 6780 gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca 6840 gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt 6900 cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc 6960 tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc 7020 cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc 7080 cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa 7140 ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac 7200 tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc 7260 caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa 7320 tttcacacag gaaacagcta tgaccatgat tacgccaagc gcgcaattaa ccctcactaa 7380 agggaacaaa agctggagct gcaagcttaa tgtagtctta tgcaatactc ttgtagtctt 7440 gcaacatggt aacgatgagt tagcaacatg ccttacaagg agagaaaaag caccgtgcat 7500 gccgattggt ggaagtaagg tggtacgatc gtgccttatt aggaaggcaa cagacgggtc 7560 tgacatggat tggacgaacc actgaattgc cgcattgcag agatattgta tttaagtgcc 7620 tagctcgata cataaacggg tctctctggt tagaccagat ctgagcctgg gagctctctg 7680 gctaactagg gaacccactg cttaagcctc aataaagctt gccttgagtg cttcaagtag 7740 tgtgtgcccg tctgttgtgt gactctggta actagagatc cctcagaccc ttttagtcag 7800 tgtggaaaat ctctagcagt ggcgcccgaa cagggacttg aaagcgaaag ggaaaccaga 7860 ggagctctct cgacgcagga ctcggcttgc tgaagcgcgc acggcaagag gcgaggggcg 7920 gcgactggtg agtacgccaa aaattttgac tagcggaggc tagaaggaga gagatgggtg 7980 cgagagcgtc agtattaagc gggggagaat tagatcgcga tgggaaaaaa ttcggttaag 8040 gccaggggga aagaaaaaat ataaattaaa acatatagta tgggcaagca gggagctaga 8100 acgattcgca gttaatcctg gcctgttaga aacatcagaa ggctgtagac aaatactggg 8160 acagctacaa ccatcccttc agacaggatc agaagaactt agatcattat ataatacagt 8220 agcaaccctc tattgtgtgc atcaaaggat agagataaaa gacaccaagg aagctttaga 8280 caagatagag gaagagcaaa acaaaagtaa gaccaccgca cagcaagcgg ccgctgatct 8340 tcagacctgg aggaggagat atgagggaca attggagaag tgaattatat aaatataaag 8400 tagtaaaaat tgaaccatta ggagtagcac ccaccaaggc aaagagaaga gtggtgcaga 8460 gagaaaaaag agcagtggga ataggagctt tgttccttgg gttcttggga gcagcaggaa 8520 gcactatggg cgcagcgtca atgacgctga cggtacaggc cagacaatta ttgtctggta 8580 tagtgcagca gcagaacaat ttgctgaggg ctattgaggc gcaacagcat ctgttgcaac 8640 tcacagtctg gggcatcaag cagctccagg caagaatcct ggctgtggaa agatacctaa 8700 aggatcaaca gctcctgggg atttggggtt gctctggaaa actcatttgc accactgctg 8760 tgccttggaa tgctagttgg agtaataaat ctctggaaca gatttggaat cacacgacct 8820 ggatggagtg ggacagagaa attaacaatt acacaagctt aatacactcc ttaattgaag 8880 aatcgcaaaa ccagcaagaa aagaatgaac aagaattatt ggaattagat aaatgggcaa 8940 gtttgtggaa ttggtttaac ataacaaatt ggctgtggta tataaaatta ttcataatga 9000 tagtaggagg cttggtaggt ttaagaatag tttttgctgt actttctata gtgaatagag 9060 ttaggcaggg atattcacca ttatcgtttc agacccacct cccaaccccg aggggaccct 9120 tgcgcctttt ccaaggcagc cctgggtttg cgcagggacg cggctgctct gggcgtggtt 9180 ccgggaaacg cagcggcgcc gaccctgggt ctcgcacatt cttcacgtcc gttcgcagcg 9240 tcacccggat cttcgccgct acccttgtgg gccccccggc gacgcttcct gctccgcccc 9300 taagtcggga aggttccttg cggttcgcgg cgtgccggac gtgacaaacg gaagccgcac 9360 gtctcactag taccctcgca gacggacagc gccagggagc aatggcagcg cgccgaccgc 9420 gatgggctgt ggccaatagc ggctgctcag cagggcgcgc cgagagcagc ggccgggaag 9480 gggcggtgcg ggaggcgggg tgtggggcgg tagtgtgggc cctgttcctg cccgcgcggt 9540 gttccgcatt ctgcaagcct ccggagcgca cgtcggcagt cggctccctc gttgaccgaa 9600 tcaccgacct ctctccccag ggggtaccca gctgtctaga gaattctaga tcttgagaca 9660 aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg 9720 ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat 9780 tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccac tttggcgccg 9840 g 9841 <210> 196 <211> 9259 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 196 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcgcc cttgccgcca ccatgccaaa aaaaaaacgc 660 aaagtggtga gcaagggcga ggagctgttc accggggtgg tgcccatcct ggtcgagctg 720 gacggcgacg taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc 780 tacggcaagc tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc 840 accctcgtga ccaccctgac ctacggcgtg cagtgcttca gccgctaccc cgaccacatg 900 aagcagcacg acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc 960 ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc 1020 ctggtgaacc gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg 1080 cacaagctgg agtacaacta caacagccac aacgtctata tcatggccga caagcagaag 1140 aacggcatca aggtgaactt caagatccgc cacaacatcg aggacggcag cgtgcagctc 1200 gccgaccact accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac 1260 cactacctga gcacccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg 1320 gtcctgctgg agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag 1380 taaaagggcg aattcgaccc agctttcttg tacaaagtgg ttggtaagcc tatccctaac 1440 cctctcctcg gtctcgattc tacgtagtaa tgagctagca gtctcgaggt taacgaattc 1500 cgcccccccc ctaacgttac tggccgaagc cgcttggaat aaggccggtg tgcgcttgtc 1560 tatatgttat tttccaccat attgccgtct tttggcaatg tgagggcccg gaaacctggc 1620 cctgtcttct tgacgagcat tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt 1680 ctgttgaatg tcgtgaagga agcagttcct ctggaagctt cttgaagaca aacaacgtct 1740 gtagcgaccc tttgcaggca gcggaacccc ccacctggcg acaggtgccc ctgcggccaa 1800 aagccacgtg tataagatac acctgcaaag gcggcacaac cccagtgcca cgttgtgagt 1860 tggatagttg tggaaagagt caaatggctc tcctcaagcg tattcaacaa ggggctgaag 1920 gatgcccaga aggtacccca ttgtatggga tctgatctgg ggcctcggtg cacatgcttt 1980 acatgtgttt agtcgaggtt aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt 2040 ttcctttgaa aaacacgata ataccatggc catgaaaaag cctgaactca ccgcgacgtc 2100 tgtcgagaag tttctgatcg aaaagttcga cagcgtctcc gacctgatgc agctctcgga 2160 gggcgaagaa tctcgtgctt tcagcttcga tgtaggaggg cgtggatatg tcctgcgggt 2220 aaatagctgc gccgatggtt tctacaaaga tcgttatgtt tatcggcact ttgcatcggc 2280 cgcgctcccg attccggaag tgcttgacat tggggaattt agcgagagcc tgacctattg 2340 cctttcatac gagaccgaga tcctgactgt cgagtacgga ttgcttccta tcggcaaaat 2400 cgtggagaag aggattgaat gtaccgtcta ttcagtcgat aataatggga acatctacac 2460 acagcccgtg gctcaatggc acgacagagg agagcaggaa gtttttgaat actgtctcga 2520 ggacggatcc ctcatccgcg ctactaaaga tcataagttt atgaccgtgg acggccagat 2580 gctgccaatt gacgaaattt ttgaacgaga gctggatctg atgagagtcg acaaccttcc 2640 aaactgacac cggtggcgcg ttaagtcgac aatcaacctc tggattacaa aatttgtgaa 2700 agattgactg gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta 2760 atgcctttgt atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa 2820 tcctggttgc tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg 2880 tgcactgtgt ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc 2940 ctttccggga ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc 3000 cttgcccgct gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg 3060 gggaaatcat cgtcctttcc ttggctgctc gcctgtgttg ccacctggat tctgcgcggg 3120 acgtccttct gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg 3180 ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc 3240 ctttgggccg cctccccgcg tcgactttaa gaccaatgac ttacaaggca gctgtagatc 3300 ttagccactt tttaaaagaa aaggggggac tggaagggct aattcactcc caacgaagac 3360 aagatctgct ttttgcttgt actgggtctc tctggttaga ccagatctga gcctgggagc 3420 tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc 3480 aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt 3540 agtcagtgtg gaaaatctct agcagtacgt atagtagttc atgtcatctt attattcagt 3600 atttataact tgcaaagaaa tgaatatcag agagtgagag gaacttgttt attgcagctt 3660 ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac 3720 tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggctctagc 3780 tatcccgccc ctaactccgc ccatcccgcc cctaactccg cccagttccg cccattctcc 3840 gccccatggc tgactaattt tttttattta tgcagaggcc gaggccgcct cggcctctga 3900 gctattccag aagtagtgag gaggcttttt tggaggccta gggacgtacc caattcgccc 3960 tatagtgagt cgtattacgc gcgctcactg gccgtcgttt tacaacgtcg tgactgggaa 4020 aaccctggcg ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt 4080 aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa 4140 tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg 4200 accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc 4260 gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga 4320 tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt 4380 gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat 4440 agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat 4500 ttataaggga ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa 4560 tttaacgcga attttaacaa aatattaacg cttacaattt aggtggcact tttcggggaa 4620 atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca 4680 tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc 4740 aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc 4800 acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt 4860 acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt 4920 ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg 4980 ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact 5040 caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg 5100 ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga 5160 aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg 5220 aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa 5280 tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac 5340 aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc 5400 cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca 5460 ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga 5520 gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta 5580 agcattggta actgtcagac caagtttact catatatact ttagattgat ttaaaacttc 5640 atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc 5700 cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt 5760 cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac 5820 cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct 5880 tcagcagagc gcagatacca aatactgttc ttctagtgta gccgtagtta ggccaccact 5940 tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg 6000 ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata 6060 aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga 6120 cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag 6180 ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg 6240 agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac 6300 ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca 6360 acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg ttctttcctg 6420 cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct gataccgctc 6480 gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa 6540 tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 6600 ttcccgactg gaaagcgggc agtgagcgca acgcaattaa tgtgagttag ctcactcatt 6660 aggcacccca ggctttacac tttatgcttc cggctcgtat gttgtgtgga attgtgagcg 6720 gataacaatt tcacacagga aacagctatg accatgatta cgccaagcgc gcaattaacc 6780 ctcactaaag ggaacaaaag ctggagctgc aagcttaatg tagtcttatg caatactctt 6840 gtagtcttgc aacatggtaa cgatgagtta gcaacatgcc ttacaaggag agaaaaagca 6900 ccgtgcatgc cgattggtgg aagtaaggtg gtacgatcgt gccttattag gaaggcaaca 6960 gacgggtctg acatggattg gacgaaccac tgaattgccg cattgcagag atattgtatt 7020 taagtgccta gctcgataca taaacgggtc tctctggtta gaccagatct gagcctggga 7080 gctctctggc taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct 7140 tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt 7200 ttagtcagtg tggaaaatct ctagcagtgg cgcccgaaca gggacttgaa agcgaaaggg 7260 aaaccagagg agctctctcg acgcaggact cggcttgctg aagcgcgcac ggcaagaggc 7320 gaggggcggc gactggtgag tacgccaaaa attttgacta gcggaggcta gaaggagaga 7380 gatgggtgcg agagcgtcag tattaagcgg gggagaatta gatcgcgatg ggaaaaaatt 7440 cggttaaggc cagggggaaa gaaaaaatat aaattaaaac atatagtatg ggcaagcagg 7500 gagctagaac gattcgcagt taatcctggc ctgttagaaa catcagaagg ctgtagacaa 7560 atactgggac agctacaacc atcccttcag acaggatcag aagaacttag atcattatat 7620 aatacagtag caaccctcta ttgtgtgcat caaaggatag agataaaaga caccaaggaa 7680 gctttagaca agatagagga agagcaaaac aaaagtaaga ccaccgcaca gcaagcggcc 7740 gctgatcttc agacctggag gaggagatat gagggacaat tggagaagtg aattatataa 7800 atataaagta gtaaaaattg aaccattagg agtagcaccc accaaggcaa agagaagagt 7860 ggtgcagaga gaaaaaagag cagtgggaat aggagctttg ttccttgggt tcttgggagc 7920 agcaggaagc actatgggcg cagcgtcaat gacgctgacg gtacaggcca gacaattatt 7980 gtctggtata gtgcagcagc agaacaattt gctgagggct attgaggcgc aacagcatct 8040 gttgcaactc acagtctggg gcatcaagca gctccaggca agaatcctgg ctgtggaaag 8100 atacctaaag gatcaacagc tcctggggat ttggggttgc tctggaaaac tcatttgcac 8160 cactgctgtg ccttggaatg ctagttggag taataaatct ctggaacaga tttggaatca 8220 cacgacctgg atggagtggg acagagaaat taacaattac acaagcttaa tacactcctt 8280 aattgaagaa tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg aattagataa 8340 atgggcaagt ttgtggaatt ggtttaacat aacaaattgg ctgtggtata taaaattatt 8400 cataatgata gtaggaggct tggtaggttt aagaatagtt tttgctgtac tttctatagt 8460 gaatagagtt aggcagggat attcaccatt atcgtttcag acccacctcc caaccccgag 8520 gggacccttg cgccttttcc aaggcagccc tgggtttgcg cagggacgcg gctgctctgg 8580 gcgtggttcc gggaaacgca gcggcgccga ccctgggtct cgcacattct tcacgtccgt 8640 tcgcagcgtc acccggatct tcgccgctac ccttgtgggc cccccggcga cgcttcctgc 8700 tccgccccta agtcgggaag gttccttgcg gttcgcggcg tgccggacgt gacaaacgga 8760 agccgcacgt ctcactagta ccctcgcaga cggacagcgc cagggagcaa tggcagcgcg 8820 ccgaccgcga tgggctgtgg ccaatagcgg ctgctcagca gggcgcgccg agagcagcgg 8880 ccgggaaggg gcggtgcggg aggcggggtg tggggcggta gtgtgggccc tgttcctgcc 8940 cgcgcggtgt tccgcattct gcaagcctcc ggagcgcacg tcggcagtcg gctccctcgt 9000 tgaccgaatc accgacctct ctccccaggg ggtacccagc tgtctagaga attctagatc 9060 ttgagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat tggggggtac 9120 agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa agaattacaa 9180 aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag agatccactt 9240 tggcgccggc tcgaggggg 9259 <210> 197 <211> 9620 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 197 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtctagcgc taccggactc agatctcgag 660 ctcaagcttc gaattccacc atgggcgtgg ccgacctgat caagaagttc gagagcatca 720 gcaaggagga gggggatcca ccggtcgcca ccatggtgag caagggcgag gcagtgatca 780 aggagttcat gcggttcaag gtgcacatgg agggctccat gaacggccac gagttcgaga 840 tcgagggcga gggcgagggc cgcccctacg agggcaccca gaccgccaag ctgaaggtga 900 ccaagggtgg ccccctgccc ttctcctggg acatcctgtc ccctcagttc atgtacggct 960 ccagggcctt caccaagcac cccgccgaca tccccgacta ctataagcag tccttccccg 1020 agggcttcaa gtgggagcgc gtgatgaact tcgaggacgg cggcgccgtg accgtgaccc 1080 aggacacctc cctggaggac ggcaccctga tctacaaggt gaagctccgc ggcaccaact 1140 tccctcctga cggccccgta atgcagaaga agacaatggg ctgggaagcg tccaccgagc 1200 ggttgtaccc cgaggacggc gtgctgaagg gcgacattaa gatggccctg cgcctgaagg 1260 acggcggccg ctacctggcg gacttcaaga ccacctacaa ggccaagaag cccgtgcaga 1320 tgcccggcgc ctacaacgtc gaccgcaagt tggacatcac ctcccacaac gaggactaca 1380 ccgtggtgga acagtacgaa cgctccgagg gccgccactc caccggcggc atggacgagc 1440 tgtacaagta attaattaag aattcgaccc agctttcttg tacaaagtgg ttggtaagcc 1500 tatccctaac cctctcctcg gtctcgattc tacgtagtaa tgagctagca gtctcgaggt 1560 taacgaattc cgcccccccc ctaacgttac tggccgaagc cgcttggaat aaggccggtg 1620 tgcgcttgtc tatatgttat tttccaccat attgccgtct tttggcaatg tgagggcccg 1680 gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc tcgccaaagg 1740 aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt cttgaagaca 1800 aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg acaggtgccc 1860 ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac cccagtgcca 1920 cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg tattcaacaa 1980 ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg ggcctcggtg 2040 cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt ctaggccccc cgaaccacgg 2100 ggacgtggtt ttcctttgaa aaacacgata ataccatggc catgattaag atcgctacgc 2160 ggaagtacct ggggaaacag aacgtctacg acataggtgt ggagcgcgat cacaactttg 2220 ctctgaaaaa tggatttatc gccagcaact gcatctcccg ccgtgcacag ggtgtcacgt 2280 tgcaagacct gcctgaaacc gaactgcccg ctgttctgca gccggtcgcg gaggccatgg 2340 atgcgatcgc tgcggccgat cttagccaga cgagcgggtt cggcccattc ggaccgcaag 2400 gaatcggtca atacactaca tggcgtgatt tcatatgcgc gattgctgat ccccatgtgt 2460 atcactggca aactgtgatg gacgacaccg tcagtgcgtc cgtcgcgcag gctctcgatg 2520 agctgatgct ttgggccgag gactgccccg aagtccggca cctcgtgcac gcggatttcg 2580 gctccaacaa tgtcctgacg gacaatggcc gcataacagc ggtcattgac tggagcgagg 2640 cgatgttcgg ggattcccaa tacgaggtcg ccaacatctt cttctggagg ccgtggttgg 2700 cttgtatgga gcagcagacg cgctacttcg agcggaggca tccggagctt gcaggatcgc 2760 cgcggctccg ggcgtatatg ctccgcattg gtcttgacca actctatcag agcttggttg 2820 acggcaattt cgatgatgca gcttgggcgc agggtcgatg cgacgcaatc gtccgatccg 2880 gagccgggac tgtcgggcgt acacaaatcg cccgcagaag cgcggccgtc tggaccgatg 2940 gctgtgtaga agtactcgcc gatagtggaa accgacgccc cagcactcgt ccgagggcaa 3000 aggaatagca ccggtggcgc gttaagtcga caatcaacct ctggattaca aaatttgtga 3060 aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt 3120 aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa 3180 atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt 3240 gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct 3300 cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg 3360 ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc 3420 ggggaaatca tcgtcctttc cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg 3480 gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct 3540 gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga gtcggatctc 3600 cctttgggcc gcctccccgc gtcgacttta agaccaatga cttacaaggc agctgtagat 3660 cttagccact ttttaaaaga aaagggggga ctggaagggc taattcactc ccaacgaaga 3720 caagatctgc tttttgcttg tactgggtct ctctggttag accagatctg agcctgggag 3780 ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc ttgagtgctt 3840 caagtagtgt gtgcccgtct gttgtgtgac tctggtaact agagatccct cagacccttt 3900 tagtcagtgt ggaaaatctc tagcagtacg tatagtagtt catgtcatct tattattcag 3960 tatttataac ttgcaaagaa atgaatatca gagagtgaga ggaacttgtt tattgcagct 4020 tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc atttttttca 4080 ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggctctag 4140 ctatcccgcc cctaactccg cccatcccgc ccctaactcc gcccagttcc gcccattctc 4200 cgccccatgg ctgactaatt ttttttattt atgcagaggc cgaggccgcc tcggcctctg 4260 agctattcca gaagtagtga ggaggctttt ttggaggcct agggacgtac ccaattcgcc 4320 ctatagtgag tcgtattacg cgcgctcact ggccgtcgtt ttacaacgtc gtgactggga 4380 aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg ccagctggcg 4440 taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga 4500 atgggacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt 4560 gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct 4620 cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg 4680 atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag 4740 tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa 4800 tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga 4860 tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa 4920 atttaacgcg aattttaaca aaatattaac gcttacaatt taggtggcac ttttcgggga 4980 aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc 5040 atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt 5100 caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct 5160 cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt 5220 tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt 5280 tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac 5340 gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac 5400 tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct 5460 gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg 5520 aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg 5580 gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca 5640 atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa 5700 caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt 5760 ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc 5820 attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg 5880 agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt 5940 aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt 6000 catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc 6060 ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct 6120 tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta 6180 ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc 6240 ttcagcagag cgcagatacc aaatactgtt cttctagtgt agccgtagtt aggccaccac 6300 ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct 6360 gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat 6420 aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg 6480 acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa 6540 gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg 6600 gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga 6660 cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc 6720 aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat gttctttcct 6780 gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc tgataccgct 6840 cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga agagcgccca 6900 atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg 6960 tttcccgact ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta gctcactcat 7020 taggcacccc aggctttaca ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc 7080 ggataacaat ttcacacagg aaacagctat gaccatgatt acgccaagcg cgcaattaac 7140 cctcactaaa gggaacaaaa gctggagctg caagcttaat gtagtcttat gcaatactct 7200 tgtagtcttg caacatggta acgatgagtt agcaacatgc cttacaagga gagaaaaagc 7260 accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg tgccttatta ggaaggcaac 7320 agacgggtct gacatggatt ggacgaacca ctgaattgcc gcattgcaga gatattgtat 7380 ttaagtgcct agctcgatac ataaacgggt ctctctggtt agaccagatc tgagcctggg 7440 agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc 7500 ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct 7560 tttagtcagt gtggaaaatc tctagcagtg gcgcccgaac agggacttga aagcgaaagg 7620 gaaaccagag gagctctctc gacgcaggac tcggcttgct gaagcgcgca cggcaagagg 7680 cgaggggcgg cgactggtga gtacgccaaa aattttgact agcggaggct agaaggagag 7740 agatgggtgc gagagcgtca gtattaagcg ggggagaatt agatcgcgat gggaaaaaat 7800 tcggttaagg ccagggggaa agaaaaaata taaattaaaa catatagtat gggcaagcag 7860 ggagctagaa cgattcgcag ttaatcctgg cctgttagaa acatcagaag gctgtagaca 7920 aatactggga cagctacaac catcccttca gacaggatca gaagaactta gatcattata 7980 taatacagta gcaaccctct attgtgtgca tcaaaggata gagataaaag acaccaagga 8040 agctttagac aagatagagg aagagcaaaa caaaagtaag accaccgcac agcaagcggc 8100 cgctgatctt cagacctgga ggaggagata tgagggacaa ttggagaagt gaattatata 8160 aatataaagt agtaaaaatt gaaccattag gagtagcacc caccaaggca aagagaagag 8220 tggtgcagag agaaaaaaga gcagtgggaa taggagcttt gttccttggg ttcttgggag 8280 cagcaggaag cactatgggc gcagcgtcaa tgacgctgac ggtacaggcc agacaattat 8340 tgtctggtat agtgcagcag cagaacaatt tgctgagggc tattgaggcg caacagcatc 8400 tgttgcaact cacagtctgg ggcatcaagc agctccaggc aagaatcctg gctgtggaaa 8460 gatacctaaa ggatcaacag ctcctgggga tttggggttg ctctggaaaa ctcatttgca 8520 ccactgctgt gccttggaat gctagttgga gtaataaatc tctggaacag atttggaatc 8580 acacgacctg gatggagtgg gacagagaaa ttaacaatta cacaagctta atacactcct 8640 taattgaaga atcgcaaaac cagcaagaaa agaatgaaca agaattattg gaattagata 8700 aatgggcaag tttgtggaat tggtttaaca taacaaattg gctgtggtat ataaaattat 8760 tcataatgat agtaggaggc ttggtaggtt taagaatagt ttttgctgta ctttctatag 8820 tgaatagagt taggcaggga tattcaccat tatcgtttca gacccacctc ccaaccccga 8880 ggggaccctt gcgccttttc caaggcagcc ctgggtttgc gcagggacgc ggctgctctg 8940 ggcgtggttc cgggaaacgc agcggcgccg accctgggtc tcgcacattc ttcacgtccg 9000 ttcgcagcgt cacccggatc ttcgccgcta cccttgtggg ccccccggcg acgcttcctg 9060 ctccgcccct aagtcgggaa ggttccttgc ggttcgcggc gtgccggacg tgacaaacgg 9120 aagccgcacg tctcactagt accctcgcag acggacagcg ccagggagca atggcagcgc 9180 gccgaccgcg atgggctgtg gccaatagcg gctgctcagc agggcgcgcc gagagcagcg 9240 gccgggaagg ggcggtgcgg gaggcggggt gtggggcggt agtgtgggcc ctgttcctgc 9300 ccgcgcggtg ttccgcattc tgcaagcctc cggagcgcac gtcggcagtc ggctccctcg 9360 ttgaccgaat caccgacctc tctccccagg gggtacccag ctgtctagag aattctagat 9420 cttgagacaa atggcagtat tcatccacaa ttttaaaaga aaagggggga ttggggggta 9480 cagtgcaggg gaaagaatag tagacataat agcaacagac atacaaacta aagaattaca 9540 aaaacaaatt acaaaaattc aaaattttcg ggtttattac agggacagca gagatccact 9600 ttggcgccgg ctcgaggggg 9620 <210> 198 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 198 gaccccacag tggggccact a 21 <210> 199 <211> 8509 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 199 gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag 60 ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga 120 aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat 180 atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga 240 cgaaacaccg accccacagt ggggccacta gttttagagc tagaaatagc aagttaaaat 300 aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt ttgttttaga 360 gctagaaata gcaagttaaa ataaggctag tccgttttta gcgcgtgcgc caattctgca 420 gacaaatggc tctagaggta cccgttacat aacttacggt aaatggcccg cctggctgac 480 cgcccaacga cccccgccca ttgacgtcaa tagtaacgcc aatagggact ttccattgac 540 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 600 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattgtgccc 660 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 720 ttaccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc cccccctccc 780 cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg ggggcggggg 840 gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc 900 ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct tttatggcga 960 ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcga 1020 cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga 1080 ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc gggctgtaat 1140 tagctgagca agaggtaagg gtttaaggga tggttggttg gtggggtatt aatgtttaat 1200 tacctggagc acctgcctga aatcactttt tttcaggttg gaccggtgcc accatggact 1260 ataaggacca cgacggagac tacaaggatc atgatattga ttacaaagac gatgacgata 1320 agatggcccc aaagaagaag cggaaggtcg gtatccacgg agtcccagca gccgacaaga 1380 agtacagcat cggcctggac atcggcacca actctgtggg ctgggccgtg atcaccgacg 1440 agtacaaggt gcccagcaag aaattcaagg tgctgggcaa caccgaccgg cacagcatca 1500 agaagaacct gatcggagcc ctgctgttcg acagcggcga aacagccgag gccacccggc 1560 tgaagagaac cgccagaaga agatacacca gacggaagaa ccggatctgc tatctgcaag 1620 agatcttcag caacgagatg gccaaggtgg acgacagctt cttccacaga ctggaagagt 1680 ccttcctggt ggaagaggat aagaagcacg agcggcaccc catcttcggc aacatcgtgg 1740 acgaggtggc ctaccacgag aagtacccca ccatctacca cctgagaaag aaactggtgg 1800 acagcaccga caaggccgac ctgcggctga tctatctggc cctggcccac atgatcaagt 1860 tccggggcca cttcctgatc gagggcgacc tgaaccccga caacagcgac gtggacaagc 1920 tgttcatcca gctggtgcag acctacaacc agctgttcga ggaaaacccc atcaacgcca 1980 gcggcgtgga cgccaaggcc atcctgtctg ccagactgag caagagcaga cggctggaaa 2040 atctgatcgc ccagctgccc ggcgagaaga agaatggcct gttcggaaac ctgattgccc 2100 tgagcctggg cctgaccccc aacttcaaga gcaacttcga cctggccgag gatgccaaac 2160 tgcagctgag caaggacacc tacgacgacg acctggacaa cctgctggcc cagatcggcg 2220 accagtacgc cgacctgttt ctggccgcca agaacctgtc cgacgccatc ctgctgagcg 2280 acatcctgag agtgaacacc gagatcacca aggcccccct gagcgcctct atgatcaaga 2340 gatacgacga gcaccaccag gacctgaccc tgctgaaagc tctcgtgcgg cagcagctgc 2400 ctgagaagta caaagagatt ttcttcgacc agagcaagaa cggctacgcc ggctacattg 2460 acggcggagc cagccaggaa gagttctaca agttcatcaa gcccatcctg gaaaagatgg 2520 acggcaccga ggaactgctc gtgaagctga acagagagga cctgctgcgg aagcagcgga 2580 ccttcgacaa cggcagcatc ccccaccaga tccacctggg agagctgcac gccattctgc 2640 ggcggcagga agatttttac ccattcctga aggacaaccg ggaaaagatc gagaagatcc 2700 tgaccttccg catcccctac tacgtgggcc ctctggccag gggaaacagc agattcgcct 2760 ggatgaccag aaagagcgag gaaaccatca ccccctggaa cttcgaggaa gtggtggaca 2820 agggcgcttc cgcccagagc ttcatcgagc ggatgaccaa cttcgataag aacctgccca 2880 acgagaaggt gctgcccaag cacagcctgc tgtacgagta cttcaccgtg tataacgagc 2940 tgaccaaagt gaaatacgtg accgagggaa tgagaaagcc cgccttcctg agcggcgagc 3000 agaaaaaggc catcgtggac ctgctgttca agaccaaccg gaaagtgacc gtgaagcagc 3060 tgaaagagga ctacttcaag aaaatcgagt gcttcgactc cgtggaaatc tccggcgtgg 3120 aagatcggtt caacgcctcc ctgggcacat accacgatct gctgaaaatt atcaaggaca 3180 aggacttcct ggacaatgag gaaaacgagg acattctgga agatatcgtg ctgaccctga 3240 cactgtttga ggacagagag atgatcgagg aacggctgaa aacctatgcc cacctgttcg 3300 acgacaaagt gatgaagcag ctgaagcggc ggagatacac cggctggggc aggctgagcc 3360 ggaagctgat caacggcatc cgggacaagc agtccggcaa gacaatcctg gatttcctga 3420 agtccgacgg cttcgccaac agaaacttca tgcagctgat ccacgacgac agcctgacct 3480 ttaaagagga catccagaaa gcccaggtgt ccggccaggg cgatagcctg cacgagcaca 3540 ttgccaatct ggccggcagc cccgccatta agaagggcat cctgcagaca gtgaaggtgg 3600 tggacgagct cgtgaaagtg atgggccggc acaagcccga gaacatcgtg atcgaaatgg 3660 ccagagagaa ccagaccacc cagaagggac agaagaacag ccgcgagaga atgaagcgga 3720 tcgaagaggg catcaaagag ctgggcagcc agatcctgaa agaacacccc gtggaaaaca 3780 cccagctgca gaacgagaag ctgtacctgt actacctgca gaatgggcgg gatatgtacg 3840 tggaccagga actggacatc aaccggctgt ccgactacga tgtggaccat atcgtgcctc 3900 agagctttct gaaggacgac tccatcgaca acaaggtgct gaccagaagc gacaagaacc 3960 ggggcaagag cgacaacgtg ccctccgaag aggtcgtgaa gaagatgaag aactactggc 4020 ggcagctgct gaacgccaag ctgattaccc agagaaagtt cgacaatctg accaaggccg 4080 agagaggcgg cctgagcgaa ctggataagg ccggcttcat caagagacag ctggtggaaa 4140 cccggcagat cacaaagcac gtggcacaga tcctggactc ccggatgaac actaagtacg 4200 acgagaatga caagctgatc cgggaagtga aagtgatcac cctgaagtcc aagctggtgt 4260 ccgatttccg gaaggatttc cagttttaca aagtgcgcga gatcaacaac taccaccacg 4320 cccacgacgc ctacctgaac gccgtcgtgg gaaccgccct gatcaaaaag taccctaagc 4380 tggaaagcga gttcgtgtac ggcgactaca aggtgtacga cgtgcggaag atgatcgcca 4440 agagcgagca ggaaatcggc aaggctaccg ccaagtactt cttctacagc aacatcatga 4500 actttttcaa gaccgagatt accctggcca acggcgagat ccggaagcgg cctctgatcg 4560 agacaaacgg cgaaaccggg gagatcgtgt gggataaggg ccgggatttt gccaccgtgc 4620 ggaaagtgct gagcatgccc caagtgaata tcgtgaaaaa gaccgaggtg cagacaggcg 4680 gcttcagcaa agagtctatc ctgcccaaga ggaacagcga taagctgatc gccagaaaga 4740 aggactggga ccctaagaag tacggcggct tcgacagccc caccgtggcc tattctgtgc 4800 tggtggtggc caaagtggaa aagggcaagt ccaagaaact gaagagtgtg aaagagctgc 4860 tggggatcac catcatggaa agaagcagct tcgagaagaa tcccatcgac tttctggaag 4920 ccaagggcta caaagaagtg aaaaaggacc tgatcatcaa gctgcctaag tactccctgt 4980 tcgagctgga aaacggccgg aagagaatgc tggcctctgc cggcgaactg cagaagggaa 5040 acgaactggc cctgccctcc aaatatgtga acttcctgta cctggccagc cactatgaga 5100 agctgaaggg ctcccccgag gataatgagc agaaacagct gtttgtggaa cagcacaagc 5160 actacctgga cgagatcatc gagcagatca gcgagttctc caagagagtg atcctggccg 5220 acgctaatct ggacaaagtg ctgtccgcct acaacaagca ccgggataag cccatcagag 5280 agcaggccga gaatatcatc cacctgttta ccctgaccaa tctgggagcc cctgccgcct 5340 tcaagtactt tgacaccacc atcgaccgga agaggtacac cagcaccaaa gaggtgctgg 5400 acgccaccct gatccaccag agcatcaccg gcctgtacga gacacggatc gacctgtctc 5460 agctgggagg cgacaaaagg ccggcggcca cgaaaaaggc cggccaggca aaaaagaaaa 5520 agtaagaatt cctagagctc gctgatcagc ctcgactgtg ccttctagtt gccagccatc 5580 tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct 5640 ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg 5700 gggtggggtg gggcaggaca gcaaggggga ggattgggaa gagaatagca ggcatgctgg 5760 ggagcggccg caggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc 5820 gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc 5880 agtgagcgag cgagcgcgca gctgcctgca ggggcgcctg atgcggtatt ttctccttac 5940 gcatctgtgc ggtatttcac accgcatacg tcaaagcaac catagtacgc gccctgtagc 6000 ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc 6060 gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt 6120 ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac 6180 ctcgacccca aaaaacttga tttgggtgat ggttcacgta gtgggccatc gccctgatag 6240 acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa 6300 actggaacaa cactcaaccc tatctcgggc tattcttttg atttataagg gattttgccg 6360 atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattttaac 6420 aaaatattaa cgtttacaat tttatggtgc actctcagta caatctgctc tgatgccgca 6480 tagttaagcc agccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg 6540 ctcccggcat ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg 6600 ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc tcgtgatacg cctattttta 6660 taggttaatg tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaaat 6720 gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg 6780 agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa 6840 catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac 6900 ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac 6960 atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt 7020 ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc 7080 gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca 7140 ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc 7200 ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag 7260 gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa 7320 ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg 7380 gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa 7440 ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg 7500 gctggctggt ttattgctga taaatctgga gccggtgagc gtggaagccg cggtatcatt 7560 gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt 7620 caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag 7680 cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat 7740 ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct 7800 taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct 7860 tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca 7920 gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc 7980 agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc 8040 aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct 8100 gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag 8160 gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc 8220 tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg 8280 agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag 8340 cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt 8400 gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac 8460 gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgt 8509 <210> 200 <211> 11194 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 200 gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa 60 atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga 120 agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc 180 ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg 240 gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc 300 gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat 360 tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg 420 acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag 480 aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa 540 cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc 600 gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca 660 cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc 720 tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc 780 tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg 840 ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta 900 tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag 960 gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga 1020 ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc 1080 tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa 1140 agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa 1200 aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc 1260 cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt 1320 agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc 1380 tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac 1440 gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca 1500 gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg 1560 ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag 1620 gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt 1680 ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat 1740 ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc 1800 acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt 1860 gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag 1920 cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca 1980 gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga 2040 gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt 2100 gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca 2160 agctcgaaat taaccctcac taaagggaac aaaagctgtg ctttctctga ccagcattct 2220 ctcccctggg cctgtgccgc tttctgtctg cagcttgtgg cctgggtcac ctctacggct 2280 ggcccagatc cttccctgcc gcctccttca ggttccgtct tcctccactc cctcttcccc 2340 ttgctctctg ctgtgttgct gcccaaggat gctctttccg gagcacttcc ttctcggcgc 2400 tgcaccacgt gatgtcctct gagcggatcc tccccgtgtc tgggtcctct ccgggcatct 2460 ctcctccctc acccaacccc atgccgtctt cactcgctgg gttccctttt ccttctcctt 2520 ctggggcctg tgccatctct cgtttcttag gatggccttc tccgacggat gtctcccttg 2580 cgtcccgcct ccccttcttg taggcctgca tcatcaccgt ttttctggac aaccccaaag 2640 taccccgtct ccctggcttt agccacctct ccatcctctt gctttctttg cctggacacc 2700 ccgttctcct gtggattcgg gtcacctctc actcctttca tttgggcagc tcccctaccc 2760 cccttacctc tctagtctgt gctagctctt ccagccccct gtcatggcat cttccagggg 2820 tccgagagct cagctagtct tcttcctcca acccgggccc ctatgtccac ttcaggacag 2880 catgtttgct gcctccaggg atcctgtgtc cccgagctgg gaccacctta tattcccagg 2940 gccggttaat gtggctctgg ttctgggtac ttttatctgt cccctccacc ccacagtggg 3000 gcaagcttct gacctcttct cttcctccca cagggcctcg agagatctgg cagcggagag 3060 ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc taggctcgag 3120 ggtaccatga ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg 3180 ctattcggct atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg 3240 ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat 3300 gaactgcagg acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca 3360 gctgtgctcg acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg 3420 gggcaggatc tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat 3480 gcaatgcggc ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa 3540 catcgcatcg agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg 3600 gacgaagagc atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgcgcatg 3660 cccgacggcg aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg 3720 gaaaatggcc gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat 3780 caggacatag cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac 3840 cgcttcctcg tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc 3900 cttcttgacg agttcttctg agtttaaacc cgctgatcag cctcgactgt gccttctagt 3960 tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact 4020 cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat 4080 tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc 4140 aggcatgctg gggatgcggt gggctctatg ggctagcggt ggcggcctcg acattgatta 4200 ttgactagta gatctggcgc gccgcctttt tacggttcct ggccttttgc tggccttttg 4260 ctcacatgtc acgtgaggcc ttaacgtctc gccctttggt ctccccctct taagtaccac 4320 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 4380 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 4440 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 4500 tttgtccaaa ctcatcggct agcttacccg gggagcatgt caaggtcaaa atcgtcaaga 4560 gcgtcagcag gcagcatatc aaggtcaaag tcgtcaaggg catcggctgg gagcatgtct 4620 aagtcaaaat cgtcaagggc gtcggtcggc ccgccgcttt cgcactttag ctgtttctcc 4680 aggccacata tgattagttc caggccgaaa aggaaggcag gttcggctcc ctgccggtcg 4740 aacagctcaa ttgcttgtct cagaagtggg ggcatagaat cggtggtagg tgtctctctt 4800 tcctcttttg ctacttgatg ctcctgttcc tccaatacgc agcccagtgt aaagtggccc 4860 acggcggaca gagcgtacag tgcgttctcc agggagaagc cttgctgaca caggaacgcg 4920 agctgatttt ccagggtttc gtactgtttc tctgttgggc gggtgccgag atgcacttta 4980 gccccgtcgc gatgtgagag gagagcacag cggtatgact tggcgttgtt ccgcagaaag 5040 tcttgccatg actcgccttc cagggggcag aagtgggtat gatgcctgtc cagcatctcg 5100 attggcaggg catcgagcag ggcccgcttg ttcttcacgt gccagtacag ggtaggctgc 5160 tcaactccca gcttttgagc gagtttcctt gtcgtcaggc cttcgatacc gacaccattg 5220 agtaattcca gagctccgtt tatgactttg ctcttgtcca gtctagacat tggaccaggg 5280 ttttcttcaa catcaccaca agtgaggaga gaacctctac cttcggcacc gggttccttt 5340 gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc tacacagcca 5400 tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt cccggctccg 5460 gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa attgccgtca 5520 accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg gagccgcggc 5580 gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc catacaagcc 5640 aaccacggcc tccagaagaa gatgttggcg acctcgtatt gggaatcccc gaacatcgcc 5700 tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt gttggagccg 5760 aaatccgcgt gcacgaggtg ccggacttcg gggcagtcct cggcccaaag catcagctca 5820 tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg ccagtgatac 5880 acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg accgattcct 5940 tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc gatcgcatcc 6000 atggcctccg cgaccggctg cagaacagcg ggcagttcgg tttcaggcag gtcttgcaac 6060 gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctaaa ttccccaatg 6120 tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac ataacgatct 6180 ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc tcctacatcg 6240 aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga gacgctgtcg 6300 aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt tttcatggtg 6360 gcggcactag taagggcgaa ttcggagcct gcttttttgt acaaacttgt tgatatctgc 6420 agaattccac cacactggac tagtggatcc gagctcggta ccaagcttct tcacgacacc 6480 tgaaatggaa gaaaaaaact ttgaaccact gtctgaggct tgagaatgaa ccaagatcca 6540 aactcaaaaa gggcaaattc caaggagaat tacatcaagt gccaagctgg cctaacttca 6600 gtctccaccc actcagtgtg gggaaactcc atcgcataaa acccctcccc ccaacctaaa 6660 gacgacgtac tccaaaagct cgagaactaa tcgaggtgcc tggacggcgc ccggtactcc 6720 gtggagtcac atgaagcgac ggctgaggac ggaaaggccc ttttcctttg tgtgggtgac 6780 tcacccgccc gctctcccga gcgccgcgtc ctccattttg agctccctgc agcagggccg 6840 ggaagcggcc atctttccgc tcacgcaact ggtgccgacc gggccagcct tgccgcccag 6900 ggcggggcga tacacggcgg cgcgaggcca ggcaccagag caggccggcc agcttgagac 6960 tacccccgtc cgattctcgg tggccgcgct cgcaggcccc gcctcgccga acatgtgcgc 7020 tgggacgcac gggccccgtc gccgcccgcg gccccaaaaa ccgaaatacc agtgtgcaga 7080 tcttggcccg catttacaag actatcttgc cagaaaaaaa gcgtcgcagc aggtcatcaa 7140 aaattttaaa tggctagaga cttatcgaaa gcagcgagac aggcgcgaag gtgccaccag 7200 attcgcacgc ggcggcccca gcgcccaggc caggcctcaa ctcaagcacg aggcgaaggg 7260 gctccttaag cgcaaggcct cgaactctcc cacccacttc caacccgaag ctcgggatca 7320 agaatcacgt actgcagcca ggtggaagta attcaaggca cgcaagggcc ataacccgta 7380 aagaggccag gcccgcggga accacacacg gcacttacct gtgttctggc ggcaaacccg 7440 ttgcgaaaaa gaacgttcac ggcgactact gcacttatat acggttctcc cccaccctcg 7500 ggaaaaaggc ggagccagta cacgacatca ctttcccagt ttaccccgcg ccaccttctc 7560 taggcaccgg ttcaattgcc gacccctccc cccaacttct cggggactgt gggcgatgtg 7620 cgctctgccc actgacgggc accggagcct cacgatcgat atgtcgagtt tactccctat 7680 cagtgataga gaacgtatgt cgagtttact ccctatcagt gatagagaac gatgtcgagt 7740 ttactcccta tcagtgatag agaacgtatg tcgagtttac tccctatcag tgatagagaa 7800 cgtatgtcga gtttactccc tatcagtgat agagaacgta tgtcgagttt atccctatca 7860 gtgatagaga acgtatgtcg agtttactcc ctatcagtga tagagaacgt atgtcgaggt 7920 aggcgtgtac ggtgggaggc ctatataagc agagctcgtt tagtgaaccg tcagatcgcc 7980 tggagaattg gctaggcacc ggtgacaagt ttgtacaaaa aagcaggctc cgaattcgcc 8040 cttactagtg ccgccaccat gaaaacattt aacatttctc aacaggatct agaattagta 8100 gaagtagcga cagagaagat tacaatgctt tatgaggata ataaacatca tgtgggagcg 8160 gcaattcgta cgaaaacagg agaaatcatt tcggcagtac atattgaagc gtatatagga 8220 cgagtaactg tttgtgcaga agccattgcg attggtagtg cagtttcgaa tggacaaaag 8280 gattttgaca cgattgtagc tgttagacac ccttattctg acgaagtaga tagaagtatt 8340 cgagtggtaa gtccttgtgg tatgtgtagg gagttgattt cagactatgc accagattgt 8400 tttgtgttaa tagaaatgaa tggcaagtta gtcaaaacta cgattgaaga actcattcca 8460 ctcaaatata cccgaaatac tagtggcagc ggcgccacaa acttctctct gctaaagcaa 8520 gcaggtgatg ttgaagaaaa ccccgggcct ggcgcgccaa tggtgagcaa gggcgaggag 8580 ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cggccacaag 8640 ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac cctgaagttc 8700 atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac cctgacctac 8760 ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt cttcaagtcc 8820 gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga cggcaactac 8880 aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat cgagctgaag 8940 ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta caactacaac 9000 agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt gaacttcaag 9060 atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca gcagaacacc 9120 cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac ccagtccgcc 9180 ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc 9240 gccgggatca ctctcggcat ggacgagctg tacaagtaat taattaagag ggcgaattcg 9300 acccagcttt cttgtacaaa gtggttgata tccagcacag tggcggccgc tcgagtctag 9360 agggcccgcg gttcgaaggt aagcctatcc ctaaccctct cctcggtctc gattctacgc 9420 gtaccggtta ggggcccgtt taaacccgct gatcagcctc gactgtgcct tctagttgcc 9480 agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca 9540 ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta 9600 ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc 9660 atgctgggga tgcggtgggc tctatggctc tagaagtcga cagtactaag ctttgacaga 9720 aaagccccat ccttaggcct cctccttcct agtctcctga tattgggtct aacccccacc 9780 tcctgttagg cagattcctt atctggtgac acacccccat ttcctggagc catctctctc 9840 cttgccagaa cctctaaggt ttgcttacga tggagccaga gaggatcctg ggagggagag 9900 cttggcaggg ggtgggaggg aaggggggga tgcgtgacct gcccggttct cagtggccac 9960 cctgcgctac cctctcccag aacctgagct gctctgacgc ggctgtctgg tgcgtttcac 10020 tgatcctggt gctgcagctt ccttacactt cccaagagga gaagcagttt ggaaaaacaa 10080 aatcagaata agttggtcct gagttctaac tttggctctt cacctttcta gtccccaatt 10140 tatattgttc ctccgtgcgt cagttttacc tgtgagataa ggccagtagc cagccccgtc 10200 ctggcagggc tgtggtgagg aggggggtgt ccgtgtggaa aactcccttt gtgagaatgg 10260 tgcgtcctag gtgttcacca ggtcgtggcc gcctctactc cctttctctt tctccatcct 10320 tctttcctta aagagtcccc agtgctatct gggacatatt cctccgccca gagcagggtc 10380 ccgcttccct aaggccctgc tctgggcttc tgggtttgag tccttggcaa gcccaggaga 10440 ggcgctcagg cttccctgtc ccccttcctc gtccaccatc tcatgcccct ggctctcctg 10500 ccccttccct acaggggttc ctggctctgc tctagcgatc gccaattcgc cctatagtga 10560 gtcgtattac aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt 10620 tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta atagcgaaga 10680 ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat gggacgcgcc 10740 ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga ccgctacact 10800 tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc 10860 cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt 10920 acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg ggccatcgcc 10980 ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt 11040 gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt tataagggat 11100 tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa 11160 ttttaacaaa atattaacgc ttacaattta ggtg 11194 <210> 201 <211> 11173 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 201 gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa 60 atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga 120 agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc 180 ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg 240 gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc 300 gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat 360 tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg 420 acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag 480 aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa 540 cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc 600 gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca 660 cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc 720 tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc 780 tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg 840 ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta 900 tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag 960 gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga 1020 ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc 1080 tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa 1140 agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa 1200 aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc 1260 cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt 1320 agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc 1380 tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac 1440 gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca 1500 gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg 1560 ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag 1620 gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt 1680 ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat 1740 ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc 1800 acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt 1860 gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag 1920 cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca 1980 gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga 2040 gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt 2100 gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca 2160 agctcgaaat taaccctcac taaagggaac aaaagctgtg ctttctctga ccagcattct 2220 ctcccctggg cctgtgccgc tttctgtctg cagcttgtgg cctgggtcac ctctacggct 2280 ggcccagatc cttccctgcc gcctccttca ggttccgtct tcctccactc cctcttcccc 2340 ttgctctctg ctgtgttgct gcccaaggat gctctttccg gagcacttcc ttctcggcgc 2400 tgcaccacgt gatgtcctct gagcggatcc tccccgtgtc tgggtcctct ccgggcatct 2460 ctcctccctc acccaacccc atgccgtctt cactcgctgg gttccctttt ccttctcctt 2520 ctggggcctg tgccatctct cgtttcttag gatggccttc tccgacggat gtctcccttg 2580 cgtcccgcct ccccttcttg taggcctgca tcatcaccgt ttttctggac aaccccaaag 2640 taccccgtct ccctggcttt agccacctct ccatcctctt gctttctttg cctggacacc 2700 ccgttctcct gtggattcgg gtcacctctc actcctttca tttgggcagc tcccctaccc 2760 cccttacctc tctagtctgt gctagctctt ccagccccct gtcatggcat cttccagggg 2820 tccgagagct cagctagtct tcttcctcca acccgggccc ctatgtccac ttcaggacag 2880 catgtttgct gcctccaggg atcctgtgtc cccgagctgg gaccacctta tattcccagg 2940 gccggttaat gtggctctgg ttctgggtac ttttatctgt cccctccacc ccacagtggg 3000 gcaagcttct gacctcttct cttcctccca cagggcctcg agagatctgg cagcggagag 3060 ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc taggctcgag 3120 ggtaccatga ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg 3180 ctattcggct atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg 3240 ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat 3300 gaactgcagg acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca 3360 gctgtgctcg acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg 3420 gggcaggatc tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat 3480 gcaatgcggc ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa 3540 catcgcatcg agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg 3600 gacgaagagc atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgcgcatg 3660 cccgacggcg aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg 3720 gaaaatggcc gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat 3780 caggacatag cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac 3840 cgcttcctcg tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc 3900 cttcttgacg agttcttctg agtttaaacc cgctgatcag cctcgactgt gccttctagt 3960 tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact 4020 cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat 4080 tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc 4140 aggcatgctg gggatgcggt gggctctatg ggctagcggt ggcggcctcg acattgatta 4200 ttgactagta gatctggcgc gccgcctttt tacggttcct ggccttttgc tggccttttg 4260 ctcacatgtc acgtgaggcc ttaacgtctc gccctttggt ctccccctct taagtaccac 4320 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 4380 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 4440 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 4500 tttgtccaaa ctcatcggct agcttacccg gggagcatgt caaggtcaaa atcgtcaaga 4560 gcgtcagcag gcagcatatc aaggtcaaag tcgtcaaggg catcggctgg gagcatgtct 4620 aagtcaaaat cgtcaagggc gtcggtcggc ccgccgcttt cgcactttag ctgtttctcc 4680 aggccacata tgattagttc caggccgaaa aggaaggcag gttcggctcc ctgccggtcg 4740 aacagctcaa ttgcttgtct cagaagtggg ggcatagaat cggtggtagg tgtctctctt 4800 tcctcttttg ctacttgatg ctcctgttcc tccaatacgc agcccagtgt aaagtggccc 4860 acggcggaca gagcgtacag tgcgttctcc agggagaagc cttgctgaca caggaacgcg 4920 agctgatttt ccagggtttc gtactgtttc tctgttgggc gggtgccgag atgcacttta 4980 gccccgtcgc gatgtgagag gagagcacag cggtatgact tggcgttgtt ccgcagaaag 5040 tcttgccatg actcgccttc cagggggcag aagtgggtat gatgcctgtc cagcatctcg 5100 attggcaggg catcgagcag ggcccgcttg ttcttcacgt gccagtacag ggtaggctgc 5160 tcaactccca gcttttgagc gagtttcctt gtcgtcaggc cttcgatacc gacaccattg 5220 agtaattcca gagctccgtt tatgactttg ctcttgtcca gtctagacat tggaccaggg 5280 ttttcttcaa catcaccaca agtgaggaga gaacctctac cttcggcacc gggttccttt 5340 gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc tacacagcca 5400 tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt cccggctccg 5460 gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa attgccgtca 5520 accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg gagccgcggc 5580 gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc catacaagcc 5640 aaccacggcc tccagaagaa gatgttggcg acctcgtatt gggaatcccc gaacatcgcc 5700 tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt gttggagccg 5760 aaatccgcgt gcacgaggtg ccggacttcg gggcagtcct cggcccaaag catcagctca 5820 tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg ccagtgatac 5880 acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg accgattcct 5940 tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc gatcgcatcc 6000 atggcctccg cgaccggctg cagaacagcg ggcagttcgg tttcaggcag gtcttgcaac 6060 gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctaaa ttccccaatg 6120 tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac ataacgatct 6180 ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc tcctacatcg 6240 aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga gacgctgtcg 6300 aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt tttcatggtg 6360 gcggcactag taagggcgaa ttcggagcct gcttttttgt acaaacttgt tgatatctgc 6420 agaattccac cacactggac tagtggatcc gagctcggta ccaagcttct tcacgacacc 6480 tgaaatggaa gaaaaaaact ttgaaccact gtctgaggct tgagaatgaa ccaagatcca 6540 aactcaaaaa gggcaaattc caaggagaat tacatcaagt gccaagctgg cctaacttca 6600 gtctccaccc actcagtgtg gggaaactcc atcgcataaa acccctcccc ccaacctaaa 6660 gacgacgtac tccaaaagct cgagaactaa tcgaggtgcc tggacggcgc ccggtactcc 6720 gtggagtcac atgaagcgac ggctgaggac ggaaaggccc ttttcctttg tgtgggtgac 6780 tcacccgccc gctctcccga gcgccgcgtc ctccattttg agctccctgc agcagggccg 6840 ggaagcggcc atctttccgc tcacgcaact ggtgccgacc gggccagcct tgccgcccag 6900 ggcggggcga tacacggcgg cgcgaggcca ggcaccagag caggccggcc agcttgagac 6960 tacccccgtc cgattctcgg tggccgcgct cgcaggcccc gcctcgccga acatgtgcgc 7020 tgggacgcac gggccccgtc gccgcccgcg gccccaaaaa ccgaaatacc agtgtgcaga 7080 tcttggcccg catttacaag actatcttgc cagaaaaaaa gcgtcgcagc aggtcatcaa 7140 aaattttaaa tggctagaga cttatcgaaa gcagcgagac aggcgcgaag gtgccaccag 7200 attcgcacgc ggcggcccca gcgcccaggc caggcctcaa ctcaagcacg aggcgaaggg 7260 gctccttaag cgcaaggcct cgaactctcc cacccacttc caacccgaag ctcgggatca 7320 agaatcacgt actgcagcca ggtggaagta attcaaggca cgcaagggcc ataacccgta 7380 aagaggccag gcccgcggga accacacacg gcacttacct gtgttctggc ggcaaacccg 7440 ttgcgaaaaa gaacgttcac ggcgactact gcacttatat acggttctcc cccaccctcg 7500 ggaaaaaggc ggagccagta cacgacatca ctttcccagt ttaccccgcg ccaccttctc 7560 taggcaccgg ttcaattgcc gacccctccc cccaacttct cggggactgt gggcgatgtg 7620 cgctctgccc actgacgggc accggagcct cacgatcgat atgtcgagtt tactccctat 7680 cagtgataga gaacgtatgt cgagtttact ccctatcagt gatagagaac gatgtcgagt 7740 ttactcccta tcagtgatag agaacgtatg tcgagtttac tccctatcag tgatagagaa 7800 cgtatgtcga gtttactccc tatcagtgat agagaacgta tgtcgagttt atccctatca 7860 gtgatagaga acgtatgtcg agtttactcc ctatcagtga tagagaacgt atgtcgaggt 7920 aggcgtgtac ggtgggaggc ctatataagc agagctcgtt tagtgaaccg tcagatcgcc 7980 tggagaattg gctaggcacc ggtgacaagt ttgtacaaaa aagcaggctc cgaattcgcc 8040 cttactagtg ccgccaccat gaaaacattt aacatttctc aacaggatct agaattagta 8100 gaagtagcga cagagaagat tacaatgctt tatgaggata ataaacatca tgtgggagcg 8160 gcaattcgta cgaaaacagg agaaatcatt tcggcagtac atattgaagc gtatatagga 8220 cgagtaactg tttgtgcaga agccattgcg attggtagtg cagtttcgaa tggacaaaag 8280 gattttgaca cgattgtagc tgttagacac ccttattctg acgaagtaga tagaagtatt 8340 cgagtggtaa gtccttgtgg tatgtgtagg gagttgattt cagactatgc accagattgt 8400 tttgtgttaa tagaaatgaa tggcaagtta gtcaaaacta cgattgaaga actcattcca 8460 ctcaaatata cccgaaatac tagtggcagc ggcgccacaa acttctctct gctaaagcaa 8520 gcaggtgatg ttgaagaaaa ccccgggcct ggcgcgccaa tggtgagcaa gggcgaggca 8580 gtgatcaagg agttcatgcg gttcaaggtg cacatggagg gctccatgaa cggccacgag 8640 ttcgagatcg agggcgaggg cgagggccgc ccctacgagg gcacccagac cgccaagctg 8700 aaggtgacca agggtggccc cctgcccttc tcctgggaca tcctgtcccc tcagttcatg 8760 tacggctcca gggccttcac caagcacccc gccgacatcc ccgactacta taagcagtcc 8820 ttccccgagg gcttcaagtg ggagcgcgtg atgaacttcg aggacggcgg cgccgtgacc 8880 gtgacccagg acacctccct ggaggacggc accctgatct acaaggtgaa gctccgtggc 8940 accaacttcc ctcctgacgg ccccgtaatg cagaagaaga caatgggctg ggaagcgtcc 9000 accgagcggt tgtaccccga ggacggcgtg ctgaagggcg acattaagat ggccctgcgc 9060 ctgaaggacg gcggccgcta cctggcggac ttcaagacca cctacaaggc caagaagccc 9120 gtgcagatgc ccggcgccta caacgtcgac cgcaagttgg acatcacctc ccacaacgag 9180 gactacaccg tggtggaaca gtacgaacgc tccgagggcc gccactccac cggcggcatg 9240 gacgagctgt acaagtgatt aattaaaagg gcgaattcga cccagctttc ttgtacaaag 9300 tggttgatat ccagcacagt ggcggccgct cgagtctaga gggcccgcgg ttcgaaggta 9360 agcctatccc taaccctctc ctcggtctcg attctacgcg taccggttag gggcccgttt 9420 aaacccgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct 9480 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 9540 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 9600 aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat gcggtgggct 9660 ctatggctct agaagtcgac agtactaagc tttgacagaa aagccccatc cttaggcctc 9720 ctccttccta gtctcctgat attgggtcta acccccacct cctgttaggc agattcctta 9780 tctggtgaca cacccccatt tcctggagcc atctctctcc ttgccagaac ctctaaggtt 9840 tgcttacgat ggagccagag aggatcctgg gagggagagc ttggcagggg gtgggaggga 9900 agggggggat gcgtgacctg cccggttctc agtggccacc ctgcgctacc ctctcccaga 9960 acctgagctg ctctgacgcg gctgtctggt gcgtttcact gatcctggtg ctgcagcttc 10020 cttacacttc ccaagaggag aagcagtttg gaaaaacaaa atcagaataa gttggtcctg 10080 agttctaact ttggctcttc acctttctag tccccaattt atattgttcc tccgtgcgtc 10140 agttttacct gtgagataag gccagtagcc agccccgtcc tggcagggct gtggtgagga 10200 ggggggtgtc cgtgtggaaa actccctttg tgagaatggt gcgtcctagg tgttcaccag 10260 gtcgtggccg cctctactcc ctttctcttt ctccatcctt ctttccttaa agagtcccca 10320 gtgctatctg ggacatattc ctccgcccag agcagggtcc cgcttcccta aggccctgct 10380 ctgggcttct gggtttgagt ccttggcaag cccaggagag gcgctcaggc ttccctgtcc 10440 cccttcctcg tccaccatct catgcccctg gctctcctgc cccttcccta caggggttcc 10500 tggctctgct ctagcgatcg ccaattcgcc ctatagtgag tcgtattaca attcactggc 10560 cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta atcgccttgc 10620 agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc 10680 ccaacagttg cgcagcctga atggcgaatg ggacgcgccc tgtagcggcg cattaagcgc 10740 ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc 10800 tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct 10860 aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa 10920 acttgattag ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc 10980 tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact 11040 caaccctatc tcggtctatt cttttgattt ataagggatt ttgccgattt cggcctattg 11100 gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgct 11160 tacaatttag gtg 11173 <210> 202 <211> 11386 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 202 gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa 60 atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga 120 agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc 180 ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg 240 gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc 300 gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat 360 tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg 420 acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag 480 aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa 540 cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc 600 gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca 660 cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc 720 tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc 780 tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg 840 ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta 900 tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag 960 gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga 1020 ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc 1080 tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa 1140 agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa 1200 aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc 1260 cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt 1320 agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc 1380 tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac 1440 gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca 1500 gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg 1560 ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag 1620 gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt 1680 ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat 1740 ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc 1800 acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt 1860 gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag 1920 cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca 1980 gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga 2040 gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt 2100 gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca 2160 agctcgaaat taaccctcac taaagggaac aaaagctgtg ctttctctga ccagcattct 2220 ctcccctggg cctgtgccgc tttctgtctg cagcttgtgg cctgggtcac ctctacggct 2280 ggcccagatc cttccctgcc gcctccttca ggttccgtct tcctccactc cctcttcccc 2340 ttgctctctg ctgtgttgct gcccaaggat gctctttccg gagcacttcc ttctcggcgc 2400 tgcaccacgt gatgtcctct gagcggatcc tccccgtgtc tgggtcctct ccgggcatct 2460 ctcctccctc acccaacccc atgccgtctt cactcgctgg gttccctttt ccttctcctt 2520 ctggggcctg tgccatctct cgtttcttag gatggccttc tccgacggat gtctcccttg 2580 cgtcccgcct ccccttcttg taggcctgca tcatcaccgt ttttctggac aaccccaaag 2640 taccccgtct ccctggcttt agccacctct ccatcctctt gctttctttg cctggacacc 2700 ccgttctcct gtggattcgg gtcacctctc actcctttca tttgggcagc tcccctaccc 2760 cccttacctc tctagtctgt gctagctctt ccagccccct gtcatggcat cttccagggg 2820 tccgagagct cagctagtct tcttcctcca acccgggccc ctatgtccac ttcaggacag 2880 catgtttgct gcctccaggg atcctgtgtc cccgagctgg gaccacctta tattcccagg 2940 gccggttaat gtggctctgg ttctgggtac ttttatctgt cccctccacc ccacagtggg 3000 gcaagcttct gacctcttct cttcctccca cagggcctcg agagatctgg cagcggagag 3060 ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc taggctcgag 3120 ggtaccatga ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg 3180 ctattcggct atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg 3240 ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat 3300 gaactgcagg acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca 3360 gctgtgctcg acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg 3420 gggcaggatc tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat 3480 gcaatgcggc ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa 3540 catcgcatcg agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg 3600 gacgaagagc atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgcgcatg 3660 cccgacggcg aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg 3720 gaaaatggcc gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat 3780 caggacatag cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac 3840 cgcttcctcg tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc 3900 cttcttgacg agttcttctg agtttaaacc cgctgatcag cctcgactgt gccttctagt 3960 tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact 4020 cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat 4080 tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc 4140 aggcatgctg gggatgcggt gggctctatg ggctagcggt ggcggcctcg acattgatta 4200 ttgactagta gatctggcgc gccgcctttt tacggttcct ggccttttgc tggccttttg 4260 ctcacatgtc acgtgaggcc ttaacgtctc gccctttggt ctccccctct taagtaccac 4320 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 4380 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 4440 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 4500 tttgtccaaa ctcatcggct agcttacccg gggagcatgt caaggtcaaa atcgtcaaga 4560 gcgtcagcag gcagcatatc aaggtcaaag tcgtcaaggg catcggctgg gagcatgtct 4620 aagtcaaaat cgtcaagggc gtcggtcggc ccgccgcttt cgcactttag ctgtttctcc 4680 aggccacata tgattagttc caggccgaaa aggaaggcag gttcggctcc ctgccggtcg 4740 aacagctcaa ttgcttgtct cagaagtggg ggcatagaat cggtggtagg tgtctctctt 4800 tcctcttttg ctacttgatg ctcctgttcc tccaatacgc agcccagtgt aaagtggccc 4860 acggcggaca gagcgtacag tgcgttctcc agggagaagc cttgctgaca caggaacgcg 4920 agctgatttt ccagggtttc gtactgtttc tctgttgggc gggtgccgag atgcacttta 4980 gccccgtcgc gatgtgagag gagagcacag cggtatgact tggcgttgtt ccgcagaaag 5040 tcttgccatg actcgccttc cagggggcag aagtgggtat gatgcctgtc cagcatctcg 5100 attggcaggg catcgagcag ggcccgcttg ttcttcacgt gccagtacag ggtaggctgc 5160 tcaactccca gcttttgagc gagtttcctt gtcgtcaggc cttcgatacc gacaccattg 5220 agtaattcca gagctccgtt tatgactttg ctcttgtcca gtctagacat tggaccaggg 5280 ttttcttcaa catcaccaca agtgaggaga gaacctctac cttcggcacc gggttccttt 5340 gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc tacacagcca 5400 tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt cccggctccg 5460 gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa attgccgtca 5520 accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg gagccgcggc 5580 gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc catacaagcc 5640 aaccacggcc tccagaagaa gatgttggcg acctcgtatt gggaatcccc gaacatcgcc 5700 tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt gttggagccg 5760 aaatccgcgt gcacgaggtg ccggacttcg gggcagtcct cggcccaaag catcagctca 5820 tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg ccagtgatac 5880 acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg accgattcct 5940 tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc gatcgcatcc 6000 atggcctccg cgaccggctg cagaacagcg ggcagttcgg tttcaggcag gtcttgcaac 6060 gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctaaa ttccccaatg 6120 tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac ataacgatct 6180 ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc tcctacatcg 6240 aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga gacgctgtcg 6300 aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt tttcatggtg 6360 gcggcactag taagggcgaa ttcggagcct gcttttttgt acaaacttgt tgatatctgc 6420 agaattccac cacactggac tagtggatcc gagctcggta ccaagcttct tcacgacacc 6480 tgaaatggaa gaaaaaaact ttgaaccact gtctgaggct tgagaatgaa ccaagatcca 6540 aactcaaaaa gggcaaattc caaggagaat tacatcaagt gccaagctgg cctaacttca 6600 gtctccaccc actcagtgtg gggaaactcc atcgcataaa acccctcccc ccaacctaaa 6660 gacgacgtac tccaaaagct cgagaactaa tcgaggtgcc tggacggcgc ccggtactcc 6720 gtggagtcac atgaagcgac ggctgaggac ggaaaggccc ttttcctttg tgtgggtgac 6780 tcacccgccc gctctcccga gcgccgcgtc ctccattttg agctccctgc agcagggccg 6840 ggaagcggcc atctttccgc tcacgcaact ggtgccgacc gggccagcct tgccgcccag 6900 ggcggggcga tacacggcgg cgcgaggcca ggcaccagag caggccggcc agcttgagac 6960 tacccccgtc cgattctcgg tggccgcgct cgcaggcccc gcctcgccga acatgtgcgc 7020 tgggacgcac gggccccgtc gccgcccgcg gccccaaaaa ccgaaatacc agtgtgcaga 7080 tcttggcccg catttacaag actatcttgc cagaaaaaaa gcgtcgcagc aggtcatcaa 7140 aaattttaaa tggctagaga cttatcgaaa gcagcgagac aggcgcgaag gtgccaccag 7200 attcgcacgc ggcggcccca gcgcccaggc caggcctcaa ctcaagcacg aggcgaaggg 7260 gctccttaag cgcaaggcct cgaactctcc cacccacttc caacccgaag ctcgggatca 7320 agaatcacgt actgcagcca ggtggaagta attcaaggca cgcaagggcc ataacccgta 7380 aagaggccag gcccgcggga accacacacg gcacttacct gtgttctggc ggcaaacccg 7440 ttgcgaaaaa gaacgttcac ggcgactact gcacttatat acggttctcc cccaccctcg 7500 ggaaaaaggc ggagccagta cacgacatca ctttcccagt ttaccccgcg ccaccttctc 7560 taggcaccgg ttcaattgcc gacccctccc cccaacttct cggggactgt gggcgatgtg 7620 cgctctgccc actgacgggc accggagcct cacgatcgat atgtcgagtt tactccctat 7680 cagtgataga gaacgtatgt cgagtttact ccctatcagt gatagagaac gatgtcgagt 7740 ttactcccta tcagtgatag agaacgtatg tcgagtttac tccctatcag tgatagagaa 7800 cgtatgtcga gtttactccc tatcagtgat agagaacgta tgtcgagttt atccctatca 7860 gtgatagaga acgtatgtcg agtttactcc ctatcagtga tagagaacgt atgtcgaggt 7920 aggcgtgtac ggtgggaggc ctatataagc agagctcgtt tagtgaaccg tcagatcgcc 7980 tggagaattg gctaggcacc ggtgacaagt ttgtacaaaa aagcaggctc cgaattcgcc 8040 cttactagtg ccgccaccat gaaaacattt aacatttctc aacaggatct agaattagta 8100 gaagtagcga cagagaagat tacaatgctt tatgaggata ataaacatca tgtgggagcg 8160 gcaattcgta cgaaaacagg agaaatcatt tcggcagtac atattgaagc gtatatagga 8220 cgagtaactg tttgtgcaga agccattgcg attggtagtg cagtttcgaa tggacaaaag 8280 gattttgaca cgattgtagc tgttagacac ccttattctg acgaagtaga tagaagtatt 8340 cgagtggtaa gtccttgtgg tatgtgcctt tcatacgaga ccgagatcct gactgtcgag 8400 tacggattgc ttcctatcgg caaaatcgtg gagaagagga ttgaatgtac cgtctattca 8460 gtcgataata atgggaacat ctacacacag cccgtggctc aatggcacga cagaggagag 8520 caggaagttt ttgaatactg tctcgaggac ggatccctca tccgcgctac taaagatcat 8580 aagtttatga ccgtggacgg ccagatgctg ccaattgacg aaatttttga acgagagctg 8640 gatctgatga gagtcgacaa ccttccaaac actagtggca gcggcgccac aaacttctct 8700 ctgctaaagc aagcaggtga tgttgaagaa aaccccgggc ctggcgcgcc aatggtgagc 8760 aagggcgagg agctgttcac cggggtggtg cccatcctgg tcgagctgga cggcgacgta 8820 aacggccaca agttcagcgt gtccggcgag ggcgagggcg atgccaccta cggcaagctg 8880 accctgaagt tcatctgcac caccggcaag ctgcccgtgc cctggcccac cctcgtgacc 8940 accctgacct acggcgtgca gtgcttcagc cgctaccccg accacatgaa gcagcacgac 9000 ttcttcaagt ccgccatgcc cgaaggctac gtccaggagc gcaccatctt cttcaaggac 9060 gacggcaact acaagacccg cgccgaggtg aagttcgagg gcgacaccct ggtgaaccgc 9120 atcgagctga agggcatcga cttcaaggag gacggcaaca tcctggggca caagctggag 9180 tacaactaca acagccacaa cgtctatatc atggccgaca agcagaagaa cggcatcaag 9240 gtgaacttca agatccgcca caacatcgag gacggcagcg tgcagctcgc cgaccactac 9300 cagcagaaca cccccatcgg cgacggcccc gtgctgctgc ccgacaacca ctacctgagc 9360 acccagtccg ccctgagcaa agaccccaac gagaagcgcg atcacatggt cctgctggag 9420 ttcgtgaccg ccgccgggat cactctcggc atggacgagc tgtacaagta attaattaag 9480 agggcgaatt cgacccagct ttcttgtaca aagtggttga tatccagcac agtggcggcc 9540 gctcgagtct agagggcccg cggttcgaag gtaagcctat ccctaaccct ctcctcggtc 9600 tcgattctac gcgtaccggt taggggcccg tttaaacccg ctgatcagcc tcgactgtgc 9660 cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag 9720 gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta 9780 ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag 9840 acaatagcag gcatgctggg gatgcggtgg gctctatggc tctagaagtc gacagtacta 9900 agctttgaca gaaaagcccc atccttaggc ctcctccttc ctagtctcct gatattgggt 9960 ctaaccccca cctcctgtta ggcagattcc ttatctggtg acacaccccc atttcctgga 10020 gccatctctc tccttgccag aacctctaag gtttgcttac gatggagcca gagaggatcc 10080 tgggagggag agcttggcag ggggtgggag ggaagggggg gatgcgtgac ctgcccggtt 10140 ctcagtggcc accctgcgct accctctccc agaacctgag ctgctctgac gcggctgtct 10200 ggtgcgtttc actgatcctg gtgctgcagc ttccttacac ttcccaagag gagaagcagt 10260 ttggaaaaac aaaatcagaa taagttggtc ctgagttcta actttggctc ttcacctttc 10320 tagtccccaa tttatattgt tcctccgtgc gtcagtttta cctgtgagat aaggccagta 10380 gccagccccg tcctggcagg gctgtggtga ggaggggggt gtccgtgtgg aaaactccct 10440 ttgtgagaat ggtgcgtcct aggtgttcac caggtcgtgg ccgcctctac tccctttctc 10500 tttctccatc cttctttcct taaagagtcc ccagtgctat ctgggacata ttcctccgcc 10560 cagagcaggg tcccgcttcc ctaaggccct gctctgggct tctgggtttg agtccttggc 10620 aagcccagga gaggcgctca ggcttccctg tcccccttcc tcgtccacca tctcatgccc 10680 ctggctctcc tgccccttcc ctacaggggt tcctggctct gctctagcga tcgccaattc 10740 gccctatagt gagtcgtatt acaattcact ggccgtcgtt ttacaacgtc gtgactggga 10800 aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg ccagctggcg 10860 taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga 10920 atgggacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt 10980 gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct 11040 cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg 11100 atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag 11160 tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa 11220 tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga 11280 tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa 11340 atttaacgcg aattttaaca aaatattaac gcttacaatt taggtg 11386 <210> 203 <211> 10975 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 203 gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa 60 atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga 120 agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc 180 ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg 240 gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc 300 gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat 360 tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg 420 acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag 480 aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa 540 cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc 600 gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca 660 cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc 720 tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc 780 tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg 840 ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta 900 tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag 960 gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga 1020 ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc 1080 tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa 1140 agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa 1200 aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc 1260 cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt 1320 agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc 1380 tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac 1440 gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca 1500 gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg 1560 ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag 1620 gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt 1680 ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat 1740 ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc 1800 acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt 1860 gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag 1920 cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca 1980 gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga 2040 gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt 2100 gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca 2160 agctcgaaat taaccctcac taaagggaac aaaagctgtg ctttctctga ccagcattct 2220 ctcccctggg cctgtgccgc tttctgtctg cagcttgtgg cctgggtcac ctctacggct 2280 ggcccagatc cttccctgcc gcctccttca ggttccgtct tcctccactc cctcttcccc 2340 ttgctctctg ctgtgttgct gcccaaggat gctctttccg gagcacttcc ttctcggcgc 2400 tgcaccacgt gatgtcctct gagcggatcc tccccgtgtc tgggtcctct ccgggcatct 2460 ctcctccctc acccaacccc atgccgtctt cactcgctgg gttccctttt ccttctcctt 2520 ctggggcctg tgccatctct cgtttcttag gatggccttc tccgacggat gtctcccttg 2580 cgtcccgcct ccccttcttg taggcctgca tcatcaccgt ttttctggac aaccccaaag 2640 taccccgtct ccctggcttt agccacctct ccatcctctt gctttctttg cctggacacc 2700 ccgttctcct gtggattcgg gtcacctctc actcctttca tttgggcagc tcccctaccc 2760 cccttacctc tctagtctgt gctagctctt ccagccccct gtcatggcat cttccagggg 2820 tccgagagct cagctagtct tcttcctcca acccgggccc ctatgtccac ttcaggacag 2880 catgtttgct gcctccaggg atcctgtgtc cccgagctgg gaccacctta tattcccagg 2940 gccggttaat gtggctctgg ttctgggtac ttttatctgt cccctccacc ccacagtggg 3000 gcaagcttct gacctcttct cttcctccca cagggcctcg agagatctgg cagcggagag 3060 ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc taggctcgag 3120 ggtaccatga ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg 3180 ctattcggct atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg 3240 ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat 3300 gaactgcagg acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca 3360 gctgtgctcg acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg 3420 gggcaggatc tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat 3480 gcaatgcggc ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa 3540 catcgcatcg agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg 3600 gacgaagagc atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgcgcatg 3660 cccgacggcg aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg 3720 gaaaatggcc gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat 3780 caggacatag cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac 3840 cgcttcctcg tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc 3900 cttcttgacg agttcttctg agtttaaacc cgctgatcag cctcgactgt gccttctagt 3960 tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact 4020 cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat 4080 tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc 4140 aggcatgctg gggatgcggt gggctctatg ggctagcggt ggcggcctcg acattgatta 4200 ttgactagta gatctggcgc gccgcctttt tacggttcct ggccttttgc tggccttttg 4260 ctcacatgtc acgtgaggcc ttaacgtctc gccctttggt ctccccctct taagtaccac 4320 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 4380 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 4440 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 4500 tttgtccaaa ctcatcggct agcttacccg gggagcatgt caaggtcaaa atcgtcaaga 4560 gcgtcagcag gcagcatatc aaggtcaaag tcgtcaaggg catcggctgg gagcatgtct 4620 aagtcaaaat cgtcaagggc gtcggtcggc ccgccgcttt cgcactttag ctgtttctcc 4680 aggccacata tgattagttc caggccgaaa aggaaggcag gttcggctcc ctgccggtcg 4740 aacagctcaa ttgcttgtct cagaagtggg ggcatagaat cggtggtagg tgtctctctt 4800 tcctcttttg ctacttgatg ctcctgttcc tccaatacgc agcccagtgt aaagtggccc 4860 acggcggaca gagcgtacag tgcgttctcc agggagaagc cttgctgaca caggaacgcg 4920 agctgatttt ccagggtttc gtactgtttc tctgttgggc gggtgccgag atgcacttta 4980 gccccgtcgc gatgtgagag gagagcacag cggtatgact tggcgttgtt ccgcagaaag 5040 tcttgccatg actcgccttc cagggggcag aagtgggtat gatgcctgtc cagcatctcg 5100 attggcaggg catcgagcag ggcccgcttg ttcttcacgt gccagtacag ggtaggctgc 5160 tcaactccca gcttttgagc gagtttcctt gtcgtcaggc cttcgatacc gacaccattg 5220 agtaattcca gagctccgtt tatgactttg ctcttgtcca gtctagacat tggaccaggg 5280 ttttcttcaa catcaccaca agtgaggaga gaacctctac cttcggcacc gggttccttt 5340 gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc tacacagcca 5400 tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt cccggctccg 5460 gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa attgccgtca 5520 accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg gagccgcggc 5580 gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc catacaagcc 5640 aaccacggcc tccagaagaa gatgttggcg acctcgtatt gggaatcccc gaacatcgcc 5700 tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt gttggagccg 5760 aaatccgcgt gcacgaggtg ccggacttcg gggcagtcct cggcccaaag catcagctca 5820 tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg ccagtgatac 5880 acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg accgattcct 5940 tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc gatcgcatcc 6000 atggcctccg cgaccggctg cagaacagcg ggcagttcgg tttcaggcag gtcttgcaac 6060 gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctaaa ttccccaatg 6120 tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac ataacgatct 6180 ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc tcctacatcg 6240 aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga gacgctgtcg 6300 aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt tttcatggtg 6360 gcggcactag taagggcgaa ttcggagcct gcttttttgt acaaacttgt tgatatctgc 6420 agaattccac cacactggac tagtggatcc gagctcggta ccaagcttct tcacgacacc 6480 tgaaatggaa gaaaaaaact ttgaaccact gtctgaggct tgagaatgaa ccaagatcca 6540 aactcaaaaa gggcaaattc caaggagaat tacatcaagt gccaagctgg cctaacttca 6600 gtctccaccc actcagtgtg gggaaactcc atcgcataaa acccctcccc ccaacctaaa 6660 gacgacgtac tccaaaagct cgagaactaa tcgaggtgcc tggacggcgc ccggtactcc 6720 gtggagtcac atgaagcgac ggctgaggac ggaaaggccc ttttcctttg tgtgggtgac 6780 tcacccgccc gctctcccga gcgccgcgtc ctccattttg agctccctgc agcagggccg 6840 ggaagcggcc atctttccgc tcacgcaact ggtgccgacc gggccagcct tgccgcccag 6900 ggcggggcga tacacggcgg cgcgaggcca ggcaccagag caggccggcc agcttgagac 6960 tacccccgtc cgattctcgg tggccgcgct cgcaggcccc gcctcgccga acatgtgcgc 7020 tgggacgcac gggccccgtc gccgcccgcg gccccaaaaa ccgaaatacc agtgtgcaga 7080 tcttggcccg catttacaag actatcttgc cagaaaaaaa gcgtcgcagc aggtcatcaa 7140 aaattttaaa tggctagaga cttatcgaaa gcagcgagac aggcgcgaag gtgccaccag 7200 attcgcacgc ggcggcccca gcgcccaggc caggcctcaa ctcaagcacg aggcgaaggg 7260 gctccttaag cgcaaggcct cgaactctcc cacccacttc caacccgaag ctcgggatca 7320 agaatcacgt actgcagcca ggtggaagta attcaaggca cgcaagggcc ataacccgta 7380 aagaggccag gcccgcggga accacacacg gcacttacct gtgttctggc ggcaaacccg 7440 ttgcgaaaaa gaacgttcac ggcgactact gcacttatat acggttctcc cccaccctcg 7500 ggaaaaaggc ggagccagta cacgacatca ctttcccagt ttaccccgcg ccaccttctc 7560 taggcaccgg ttcaattgcc gacccctccc cccaacttct cggggactgt gggcgatgtg 7620 cgctctgccc actgacgggc accggagcct cacgatcgat atgtcgagtt tactccctat 7680 cagtgataga gaacgtatgt cgagtttact ccctatcagt gatagagaac gatgtcgagt 7740 ttactcccta tcagtgatag agaacgtatg tcgagtttac tccctatcag tgatagagaa 7800 cgtatgtcga gtttactccc tatcagtgat agagaacgta tgtcgagttt atccctatca 7860 gtgatagaga acgtatgtcg agtttactcc ctatcagtga tagagaacgt atgtcgaggt 7920 aggcgtgtac ggtgggaggc ctatataagc agagctcgtt tagtgaaccg tcagatcgcc 7980 tggagaattg gctaggcacc ggtgacaagt ttgtacaaaa aagcaggctc cgaattcgcc 8040 cttactagtg ccgccaccat gattaagatc gctacgcgga agtacctggg gaaacagaac 8100 gtctacgaca taggtgtgga gcgcgatcac aactttgctc tgaaaaatgg atttatcgcc 8160 agcaactgta gggagttgat ttcagactat gcaccagatt gttttgtgtt aatagaaatg 8220 aatggcaagt tagtcaaaac tacgattgaa gaactcattc cactcaaata tacccgaaat 8280 actagtggca gcggcgccac aaacttctct ctgctaaagc aagcaggtga tgttgaagaa 8340 aaccccgggc ctggcgcgcc aatggtgagc aagggcgagg cagtgatcaa ggagttcatg 8400 cggttcaagg tgcacatgga gggctccatg aacggccacg agttcgagat cgagggcgag 8460 ggcgagggcc gcccctacga gggcacccag accgccaagc tgaaggtgac caagggtggc 8520 cccctgccct tctcctggga catcctgtcc cctcagttca tgtacggctc cagggccttc 8580 accaagcacc ccgccgacat ccccgactac tataagcagt ccttccccga gggcttcaag 8640 tgggagcgcg tgatgaactt cgaggacggc ggcgccgtga ccgtgaccca ggacacctcc 8700 ctggaggacg gcaccctgat ctacaaggtg aagctccgtg gcaccaactt ccctcctgac 8760 ggccccgtaa tgcagaagaa gacaatgggc tgggaagcgt ccaccgagcg gttgtacccc 8820 gaggacggcg tgctgaaggg cgacattaag atggccctgc gcctgaagga cggcggccgc 8880 tacctggcgg acttcaagac cacctacaag gccaagaagc ccgtgcagat gcccggcgcc 8940 tacaacgtcg accgcaagtt ggacatcacc tcccacaacg aggactacac cgtggtggaa 9000 cagtacgaac gctccgaggg ccgccactcc accggcggca tggacgagct gtacaagtga 9060 ttaattaaaa gggcgaattc gacccagctt tcttgtacaa agtggttgat atccagcaca 9120 gtggcggccg ctcgagtcta gagggcccgc ggttcgaagg taagcctatc cctaaccctc 9180 tcctcggtct cgattctacg cgtaccggtt aggggcccgt ttaaacccgc tgatcagcct 9240 cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga 9300 ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt 9360 gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg 9420 attgggaaga caatagcagg catgctgggg atgcggtggg ctctatggct ctagaagtcg 9480 acagtactaa gctttgacag aaaagcccca tccttaggcc tcctccttcc tagtctcctg 9540 atattgggtc taacccccac ctcctgttag gcagattcct tatctggtga cacaccccca 9600 tttcctggag ccatctctct ccttgccaga acctctaagg tttgcttacg atggagccag 9660 agaggatcct gggagggaga gcttggcagg gggtgggagg gaaggggggg atgcgtgacc 9720 tgcccggttc tcagtggcca ccctgcgcta ccctctccca gaacctgagc tgctctgacg 9780 cggctgtctg gtgcgtttca ctgatcctgg tgctgcagct tccttacact tcccaagagg 9840 agaagcagtt tggaaaaaca aaatcagaat aagttggtcc tgagttctaa ctttggctct 9900 tcacctttct agtccccaat ttatattgtt cctccgtgcg tcagttttac ctgtgagata 9960 aggccagtag ccagccccgt cctggcaggg ctgtggtgag gaggggggtg tccgtgtgga 10020 aaactccctt tgtgagaatg gtgcgtccta ggtgttcacc aggtcgtggc cgcctctact 10080 ccctttctct ttctccatcc ttctttcctt aaagagtccc cagtgctatc tgggacatat 10140 tcctccgccc agagcagggt cccgcttccc taaggccctg ctctgggctt ctgggtttga 10200 gtccttggca agcccaggag aggcgctcag gcttccctgt cccccttcct cgtccaccat 10260 ctcatgcccc tggctctcct gccccttccc tacaggggtt cctggctctg ctctagcgat 10320 cgccaattcg ccctatagtg agtcgtatta caattcactg gccgtcgttt tacaacgtcg 10380 tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc cccctttcgc 10440 cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct 10500 gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac 10560 gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc 10620 ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt 10680 agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg 10740 ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac 10800 gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta 10860 ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa atgagctgat 10920 ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt aggtg 10975 <210> 204 <211> 11947 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 204 gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa 60 atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga 120 agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc 180 ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg 240 gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc 300 gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat 360 tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg 420 acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag 480 aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa 540 cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc 600 gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca 660 cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc 720 tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc 780 tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg 840 ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta 900 tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag 960 gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga 1020 ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc 1080 tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa 1140 agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa 1200 aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc 1260 cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt 1320 agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc 1380 tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac 1440 gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca 1500 gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg 1560 ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag 1620 gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt 1680 ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat 1740 ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc 1800 acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt 1860 gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag 1920 cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca 1980 gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga 2040 gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt 2100 gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca 2160 agctcgaaat taaccctcac taaagggaac aaaagctgtg ctttctctga ccagcattct 2220 ctcccctggg cctgtgccgc tttctgtctg cagcttgtgg cctgggtcac ctctacggct 2280 ggcccagatc cttccctgcc gcctccttca ggttccgtct tcctccactc cctcttcccc 2340 ttgctctctg ctgtgttgct gcccaaggat gctctttccg gagcacttcc ttctcggcgc 2400 tgcaccacgt gatgtcctct gagcggatcc tccccgtgtc tgggtcctct ccgggcatct 2460 ctcctccctc acccaacccc atgccgtctt cactcgctgg gttccctttt ccttctcctt 2520 ctggggcctg tgccatctct cgtttcttag gatggccttc tccgacggat gtctcccttg 2580 cgtcccgcct ccccttcttg taggcctgca tcatcaccgt ttttctggac aaccccaaag 2640 taccccgtct ccctggcttt agccacctct ccatcctctt gctttctttg cctggacacc 2700 ccgttctcct gtggattcgg gtcacctctc actcctttca tttgggcagc tcccctaccc 2760 cccttacctc tctagtctgt gctagctctt ccagccccct gtcatggcat cttccagggg 2820 tccgagagct cagctagtct tcttcctcca acccgggccc ctatgtccac ttcaggacag 2880 catgtttgct gcctccaggg atcctgtgtc cccgagctgg gaccacctta tattcccagg 2940 gccggttaat gtggctctgg ttctgggtac ttttatctgt cccctccacc ccacagtggg 3000 gcaagcttct gacctcttct cttcctccca cagggcctcg agagatctgg cagcggagag 3060 ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc taggctcgag 3120 ggtaccatga ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg 3180 ctattcggct atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg 3240 ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat 3300 gaactgcagg acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca 3360 gctgtgctcg acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg 3420 gggcaggatc tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat 3480 gcaatgcggc ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa 3540 catcgcatcg agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg 3600 gacgaagagc atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgcgcatg 3660 cccgacggcg aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg 3720 gaaaatggcc gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat 3780 caggacatag cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac 3840 cgcttcctcg tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc 3900 cttcttgacg agttcttctg agtttaaacc cgctgatcag cctcgactgt gccttctagt 3960 tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact 4020 cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat 4080 tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc 4140 aggcatgctg gggatgcggt gggctctatg ggctagcggt ggcggcctcg acattgatta 4200 ttgactagta gatctggcgc gccgcctttt tacggttcct ggccttttgc tggccttttg 4260 ctcacatgtc acgtgaggcc ttaacgtctc gccctttggt ctccccctct taagtaccac 4320 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 4380 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 4440 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 4500 tttgtccaaa ctcatcggct agcttacccg gggagcatgt caaggtcaaa atcgtcaaga 4560 gcgtcagcag gcagcatatc aaggtcaaag tcgtcaaggg catcggctgg gagcatgtct 4620 aagtcaaaat cgtcaagggc gtcggtcggc ccgccgcttt cgcactttag ctgtttctcc 4680 aggccacata tgattagttc caggccgaaa aggaaggcag gttcggctcc ctgccggtcg 4740 aacagctcaa ttgcttgtct cagaagtggg ggcatagaat cggtggtagg tgtctctctt 4800 tcctcttttg ctacttgatg ctcctgttcc tccaatacgc agcccagtgt aaagtggccc 4860 acggcggaca gagcgtacag tgcgttctcc agggagaagc cttgctgaca caggaacgcg 4920 agctgatttt ccagggtttc gtactgtttc tctgttgggc gggtgccgag atgcacttta 4980 gccccgtcgc gatgtgagag gagagcacag cggtatgact tggcgttgtt ccgcagaaag 5040 tcttgccatg actcgccttc cagggggcag aagtgggtat gatgcctgtc cagcatctcg 5100 attggcaggg catcgagcag ggcccgcttg ttcttcacgt gccagtacag ggtaggctgc 5160 tcaactccca gcttttgagc gagtttcctt gtcgtcaggc cttcgatacc gacaccattg 5220 agtaattcca gagctccgtt tatgactttg ctcttgtcca gtctagacat tggaccaggg 5280 ttttcttcaa catcaccaca agtgaggaga gaacctctac cttcggcacc gggatttcgg 5340 gtatatttga gtggaatgag ttcttcaatc gtagttttga ctaacttgcc attcatttct 5400 attaacacaa aacaatctgg tgcatagtct gaaatcaact ccctacacat accacaagga 5460 cttaccactc gaatacttct atctacttcg tcagaataag ggtgtctaac agctacaatc 5520 gtgtcaaaat ccttttgtcc attcgaaact gcactaccaa tcgcaatggc ttctgcacaa 5580 acagttactc gtcctatata cgcttcaata tgtactgccg aaatgatttc tcctgttttc 5640 gtacgaattg ccgctcccac atgatgttta ttatcctcat aaagcattgt aatcttctct 5700 gtcgctactt ctactaattc tagatcctgt tgagaaatgt taaatgtttt catggtggcg 5760 gcactagtaa gggcgaattc ggagcctgct tttttgtaca aacttgttga tatctgcaga 5820 attccaccac actggactag tggatccgag ctcggtacca agcttcttca cgacacctga 5880 aatggaagaa aaaaactttg aaccactgtc tgaggcttga gaatgaacca agatccaaac 5940 tcaaaaaggg caaattccaa ggagaattac atcaagtgcc aagctggcct aacttcagtc 6000 tccacccact cagtgtgggg aaactccatc gcataaaacc cctcccccca acctaaagac 6060 gacgtactcc aaaagctcga gaactaatcg aggtgcctgg acggcgcccg gtactccgtg 6120 gagtcacatg aagcgacggc tgaggacgga aaggcccttt tcctttgtgt gggtgactca 6180 cccgcccgct ctcccgagcg ccgcgtcctc cattttgagc tccctgcagc agggccggga 6240 agcggccatc tttccgctca cgcaactggt gccgaccggg ccagccttgc cgcccagggc 6300 ggggcgatac acggcggcgc gaggccaggc accagagcag gccggccagc ttgagactac 6360 ccccgtccga ttctcggtgg ccgcgctcgc aggccccgcc tcgccgaaca tgtgcgctgg 6420 gacgcacggg ccccgtcgcc gcccgcggcc ccaaaaaccg aaataccagt gtgcagatct 6480 tggcccgcat ttacaagact atcttgccag aaaaaaagcg tcgcagcagg tcatcaaaaa 6540 ttttaaatgg ctagagactt atcgaaagca gcgagacagg cgcgaaggtg ccaccagatt 6600 cgcacgcggc ggccccagcg cccaggccag gcctcaactc aagcacgagg cgaaggggct 6660 ccttaagcgc aaggcctcga actctcccac ccacttccaa cccgaagctc gggatcaaga 6720 atcacgtact gcagccaggt ggaagtaatt caaggcacgc aagggccata acccgtaaag 6780 aggccaggcc cgcgggaacc acacacggca cttacctgtg ttctggcggc aaacccgttg 6840 cgaaaaagaa cgttcacggc gactactgca cttatatacg gttctccccc accctcggga 6900 aaaaggcgga gccagtacac gacatcactt tcccagttta ccccgcgcca ccttctctag 6960 gcaccggttc aattgccgac ccctcccccc aacttctcgg ggactgtggg cgatgtgcgc 7020 tctgcccact gacgggcacc ggagcctcac gatcgatatg tcgagtttac tccctatcag 7080 tgatagagaa cgtatgtcga gtttactccc tatcagtgat agagaacgat gtcgagttta 7140 ctccctatca gtgatagaga acgtatgtcg agtttactcc ctatcagtga tagagaacgt 7200 atgtcgagtt tactccctat cagtgataga gaacgtatgt cgagtttatc cctatcagtg 7260 atagagaacg tatgtcgagt ttactcccta tcagtgatag agaacgtatg tcgaggtagg 7320 cgtgtacggt gggaggccta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg 7380 agaattggct aggcaccggt gacaagtttg tacaaaaaag caggctccga attcgccctt 7440 actagtgccg ccaccatgaa aaagcctgaa ctcaccgcga cgtctgtcga gaagtttctg 7500 atcgaaaagt tcgacagcgt ctccgacctg atgcagctct cggagggcga agaatctcgt 7560 gctttcagct tcgatgtagg agggcgtgga tatgtcctgc gggtaaatag ctgcgccgat 7620 ggtttctaca aagatcgtta tgtttatcgg cactttgcat cggccgcgct cccgattccg 7680 gaagtgcttg acattgggga atttagcgag agcctgacct attgcatctc ccgccgtgca 7740 cagggtgtca cgttgcaaga cctgcctgaa accgaactgc ccgctgttct gcagccggtc 7800 gcggaggcca tggatgcgat cgctgcggcc gatcttagcc agacgagcgg gttcggccca 7860 ttcggaccgc aaggaatcgg tcaatacact acatggcgtg atttcatatg cgcgattgct 7920 gatccccatg tgtatcactg gcaaactgtg atggacgaca ccgtcagtgc gtccgtcgcg 7980 caggctctcg atgagctgat gctttgggcc gaggactgcc ccgaagtccg gcacctcgtg 8040 cacgcggatt tcggctccaa caatgtcctg acggacaatg gccgcataac agcggtcatt 8100 gactggagcg aggcgatgtt cggggattcc caatacgagg tcgccaacat cttcttctgg 8160 aggccgtggt tggcttgtat ggagcagcag acgcgctact tcgagcggag gcatccggag 8220 cttgcaggat cgccgcggct ccgggcgtat atgctccgca ttggtcttga ccaactctat 8280 cagagcttgg ttgacggcaa tttcgatgat gcagcttggg cgcagggtcg atgcgacgca 8340 atcgtccgat ccggagccgg gactgtcggg cgtacacaaa tcgcccgcag aagcgcggcc 8400 gtctggaccg atggctgtgt agaagtactc gccgatagtg gaaaccgacg ccccagcact 8460 cgtccgaggg caaaggaaac tagtggcagc ggcgccacaa acttctctct gctaaagcaa 8520 gcaggtgatg ttgaagaaaa ccccgggcct ggcgcgccaa tgaatacact cgagatggac 8580 atcatcagcg tggctctgaa gaggcactcc accaaggctt tcgacgcttc caagaaactg 8640 acccctgaac aggccgagca gatcaagacc ctgctccagt acagccctag ctccaccaac 8700 agccagcctt ggcacttcat cgtggctagc accgaggaag gcaaagctag ggtggctaag 8760 agcgccgctg gcaactacgt gttcaacgag aggaagatgc tggatgctag ccacgtggtg 8820 gtgttctgcg ctaagaccgc catggacgat gtgtggctga agctggtggt ggatcaggaa 8880 gatgctgatg gcaggttcgc tacccctgaa gctaaggccg ctaacgacaa gggcaggaag 8940 ttcttcgccg acatgcacag gaaggatctg cacgatgatg ctgagtggat ggccaagcag 9000 gtgtacctga acgtgggcaa cttcctgctc ggcgtggctg ccctgggcct cgatgctgtg 9060 cccatcgaag gcttcgatgc tgctatcctg gatgccgagt tcggcctgaa ggagaaaggc 9120 tacaccagcc tggtggtggt gcctgtgggc caccacagcg tggaggactt caacgctacc 9180 ctgcctaaga gcaggctgcc ccagaacatc accctgaccg aggtgggccg gccaggctcg 9240 ggccagtgta ctaattatgc tctcttgaaa ttggctggag atgttgagag caacccaggt 9300 cccttaatta agatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg 9360 gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc 9420 gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg 9480 ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag ccgctacccc 9540 gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag 9600 cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag 9660 ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac 9720 atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat catggccgac 9780 aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga ggacggcagc 9840 gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg 9900 cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc 9960 gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag 10020 ctgtacaagt aattaattaa gagggcgaat tcgacccagc tttcttgtac aaagtggttg 10080 atatccagca cagtggcggc cgctcgagtc tagagggccc gcggttcgaa ggtaagccta 10140 tccctaaccc tctcctcggt ctcgattcta cgcgtaccgg ttaggggccc gtttaaaccc 10200 gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg 10260 tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa 10320 ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca 10380 gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg 10440 ctctagaagt cgacagtact aagctttgac agaaaagccc catccttagg cctcctcctt 10500 cctagtctcc tgatattggg tctaaccccc acctcctgtt aggcagattc cttatctggt 10560 gacacacccc catttcctgg agccatctct ctccttgcca gaacctctaa ggtttgctta 10620 cgatggagcc agagaggatc ctgggaggga gagcttggca gggggtggga gggaaggggg 10680 ggatgcgtga cctgcccggt tctcagtggc caccctgcgc taccctctcc cagaacctga 10740 gctgctctga cgcggctgtc tggtgcgttt cactgatcct ggtgctgcag cttccttaca 10800 cttcccaaga ggagaagcag tttggaaaaa caaaatcaga ataagttggt cctgagttct 10860 aactttggct cttcaccttt ctagtcccca atttatattg ttcctccgtg cgtcagtttt 10920 acctgtgaga taaggccagt agccagcccc gtcctggcag ggctgtggtg aggagggggg 10980 tgtccgtgtg gaaaactccc tttgtgagaa tggtgcgtcc taggtgttca ccaggtcgtg 11040 gccgcctcta ctccctttct ctttctccat ccttctttcc ttaaagagtc cccagtgcta 11100 tctgggacat attcctccgc ccagagcagg gtcccgcttc cctaaggccc tgctctgggc 11160 ttctgggttt gagtccttgg caagcccagg agaggcgctc aggcttccct gtcccccttc 11220 ctcgtccacc atctcatgcc cctggctctc ctgccccttc cctacagggg ttcctggctc 11280 tgctctagcg atcgccaatt cgccctatag tgagtcgtat tacaattcac tggccgtcgt 11340 tttacaacgt cgtgactggg aaaaccctgg cgttacccaa cttaatcgcc ttgcagcaca 11400 tccccctttc gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca 11460 gttgcgcagc ctgaatggcg aatgggacgc gccctgtagc ggcgcattaa gcgcggcggg 11520 tgtggtggtt acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt 11580 cgctttcttc ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg 11640 ggggctccct ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga 11700 ttagggtgat ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac 11760 gttggagtcc acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc 11820 tatctcggtc tattcttttg atttataagg gattttgccg atttcggcct attggttaaa 11880 aaatgagctg atttaacaaa aatttaacgc gaattttaac aaaatattaa cgcttacaat 11940 ttaggtg 11947 <210> 205 <211> 11938 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 205 gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa 60 atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga 120 agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc 180 ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg 240 gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc 300 gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat 360 tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg 420 acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag 480 aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa 540 cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc 600 gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca 660 cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc 720 tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc 780 tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg 840 ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta 900 tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag 960 gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga 1020 ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc 1080 tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa 1140 agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa 1200 aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc 1260 cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt 1320 agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc 1380 tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac 1440 gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca 1500 gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg 1560 ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag 1620 gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt 1680 ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat 1740 ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc 1800 acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt 1860 gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag 1920 cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca 1980 gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga 2040 gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt 2100 gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca 2160 agctcgaaat taaccctcac taaagggaac aaaagctgtg ctttctctga ccagcattct 2220 ctcccctggg cctgtgccgc tttctgtctg cagcttgtgg cctgggtcac ctctacggct 2280 ggcccagatc cttccctgcc gcctccttca ggttccgtct tcctccactc cctcttcccc 2340 ttgctctctg ctgtgttgct gcccaaggat gctctttccg gagcacttcc ttctcggcgc 2400 tgcaccacgt gatgtcctct gagcggatcc tccccgtgtc tgggtcctct ccgggcatct 2460 ctcctccctc acccaacccc atgccgtctt cactcgctgg gttccctttt ccttctcctt 2520 ctggggcctg tgccatctct cgtttcttag gatggccttc tccgacggat gtctcccttg 2580 cgtcccgcct ccccttcttg taggcctgca tcatcaccgt ttttctggac aaccccaaag 2640 taccccgtct ccctggcttt agccacctct ccatcctctt gctttctttg cctggacacc 2700 ccgttctcct gtggattcgg gtcacctctc actcctttca tttgggcagc tcccctaccc 2760 cccttacctc tctagtctgt gctagctctt ccagccccct gtcatggcat cttccagggg 2820 tccgagagct cagctagtct tcttcctcca acccgggccc ctatgtccac ttcaggacag 2880 catgtttgct gcctccaggg atcctgtgtc cccgagctgg gaccacctta tattcccagg 2940 gccggttaat gtggctctgg ttctgggtac ttttatctgt cccctccacc ccacagtggg 3000 gcaagcttct gacctcttct cttcctccca cagggcctcg agagatctgg cagcggagag 3060 ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc taggctcgag 3120 ggtaccatga ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg 3180 ctattcggct atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg 3240 ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat 3300 gaactgcagg acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca 3360 gctgtgctcg acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg 3420 gggcaggatc tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat 3480 gcaatgcggc ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa 3540 catcgcatcg agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg 3600 gacgaagagc atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgcgcatg 3660 cccgacggcg aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg 3720 gaaaatggcc gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat 3780 caggacatag cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac 3840 cgcttcctcg tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc 3900 cttcttgacg agttcttctg agtttaaacc cgctgatcag cctcgactgt gccttctagt 3960 tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact 4020 cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat 4080 tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc 4140 aggcatgctg gggatgcggt gggctctatg ggctagcggt ggcggcctcg acattgatta 4200 ttgactagta gatctggcgc gccgcctttt tacggttcct ggccttttgc tggccttttg 4260 ctcacatgtc acgtgaggcc ttaacgtctc gccctttggt ctccccctct taagtaccac 4320 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 4380 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 4440 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 4500 tttgtccaaa ctcatcggct agcttacccg gggagcatgt caaggtcaaa atcgtcaaga 4560 gcgtcagcag gcagcatatc aaggtcaaag tcgtcaaggg catcggctgg gagcatgtct 4620 aagtcaaaat cgtcaagggc gtcggtcggc ccgccgcttt cgcactttag ctgtttctcc 4680 aggccacata tgattagttc caggccgaaa aggaaggcag gttcggctcc ctgccggtcg 4740 aacagctcaa ttgcttgtct cagaagtggg ggcatagaat cggtggtagg tgtctctctt 4800 tcctcttttg ctacttgatg ctcctgttcc tccaatacgc agcccagtgt aaagtggccc 4860 acggcggaca gagcgtacag tgcgttctcc agggagaagc cttgctgaca caggaacgcg 4920 agctgatttt ccagggtttc gtactgtttc tctgttgggc gggtgccgag atgcacttta 4980 gccccgtcgc gatgtgagag gagagcacag cggtatgact tggcgttgtt ccgcagaaag 5040 tcttgccatg actcgccttc cagggggcag aagtgggtat gatgcctgtc cagcatctcg 5100 attggcaggg catcgagcag ggcccgcttg ttcttcacgt gccagtacag ggtaggctgc 5160 tcaactccca gcttttgagc gagtttcctt gtcgtcaggc cttcgatacc gacaccattg 5220 agtaattcca gagctccgtt tatgactttg ctcttgtcca gtctagacat tggaccaggg 5280 ttttcttcaa catcaccaca agtgaggaga gaacctctac cttcggcacc gggatttcgg 5340 gtatatttga gtggaatgag ttcttcaatc gtagttttga ctaacttgcc attcatttct 5400 attaacacaa aacaatctgg tgcatagtct gaaatcaact ccctacacat accacaagga 5460 cttaccactc gaatacttct atctacttcg tcagaataag ggtgtctaac agctacaatc 5520 gtgtcaaaat ccttttgtcc attcgaaact gcactaccaa tcgcaatggc ttctgcacaa 5580 acagttactc gtcctatata cgcttcaata tgtactgccg aaatgatttc tcctgttttc 5640 gtacgaattg ccgctcccac atgatgttta ttatcctcat aaagcattgt aatcttctct 5700 gtcgctactt ctactaattc tagatcctgt tgagaaatgt taaatgtttt catggtggcg 5760 gcactagtaa gggcgaattc ggagcctgct tttttgtaca aacttgttga tatctgcaga 5820 attccaccac actggactag tggatccgag ctcggtacca agcttcttca cgacacctga 5880 aatggaagaa aaaaactttg aaccactgtc tgaggcttga gaatgaacca agatccaaac 5940 tcaaaaaggg caaattccaa ggagaattac atcaagtgcc aagctggcct aacttcagtc 6000 tccacccact cagtgtgggg aaactccatc gcataaaacc cctcccccca acctaaagac 6060 gacgtactcc aaaagctcga gaactaatcg aggtgcctgg acggcgcccg gtactccgtg 6120 gagtcacatg aagcgacggc tgaggacgga aaggcccttt tcctttgtgt gggtgactca 6180 cccgcccgct ctcccgagcg ccgcgtcctc cattttgagc tccctgcagc agggccggga 6240 agcggccatc tttccgctca cgcaactggt gccgaccggg ccagccttgc cgcccagggc 6300 ggggcgatac acggcggcgc gaggccaggc accagagcag gccggccagc ttgagactac 6360 ccccgtccga ttctcggtgg ccgcgctcgc aggccccgcc tcgccgaaca tgtgcgctgg 6420 gacgcacggg ccccgtcgcc gcccgcggcc ccaaaaaccg aaataccagt gtgcagatct 6480 tggcccgcat ttacaagact atcttgccag aaaaaaagcg tcgcagcagg tcatcaaaaa 6540 ttttaaatgg ctagagactt atcgaaagca gcgagacagg cgcgaaggtg ccaccagatt 6600 cgcacgcggc ggccccagcg cccaggccag gcctcaactc aagcacgagg cgaaggggct 6660 ccttaagcgc aaggcctcga actctcccac ccacttccaa cccgaagctc gggatcaaga 6720 atcacgtact gcagccaggt ggaagtaatt caaggcacgc aagggccata acccgtaaag 6780 aggccaggcc cgcgggaacc acacacggca cttacctgtg ttctggcggc aaacccgttg 6840 cgaaaaagaa cgttcacggc gactactgca cttatatacg gttctccccc accctcggga 6900 aaaaggcgga gccagtacac gacatcactt tcccagttta ccccgcgcca ccttctctag 6960 gcaccggttc aattgccgac ccctcccccc aacttctcgg ggactgtggg cgatgtgcgc 7020 tctgcccact gacgggcacc ggagcctcac gatcgatatg tcgagtttac tccctatcag 7080 tgatagagaa cgtatgtcga gtttactccc tatcagtgat agagaacgat gtcgagttta 7140 ctccctatca gtgatagaga acgtatgtcg agtttactcc ctatcagtga tagagaacgt 7200 atgtcgagtt tactccctat cagtgataga gaacgtatgt cgagtttatc cctatcagtg 7260 atagagaacg tatgtcgagt ttactcccta tcagtgatag agaacgtatg tcgaggtagg 7320 cgtgtacggt gggaggccta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg 7380 agaattggct aggcaccggt gacaagtttg tacaaaaaag caggctccga attcgccctt 7440 actagtgccg ccaccatgaa aaagcctgaa ctcaccgcga cgtctgtcga gaagtttctg 7500 atcgaaaagt tcgacagcgt ctccgacctg atgcagctct cggagggcga agaatctcgt 7560 gctttcagct tcgatgtagg agggcgtgga tatgtcctgc gggtaaatag ctgcgccgat 7620 ggtttctaca aagatcgtta tgtttatcgg cactttgcat cggccgcgct cccgattccg 7680 gaagtgcttg acattgggga atttagcgag agcctgacct attgcatctc ccgccgtgca 7740 cagggtgtca cgttgcaaga cctgcctgaa accgaactgc ccgctgttct gcagccggtc 7800 gcggaggcca tggatgcgat cgctgcggcc gatcttagcc agacgagcgg gttcggccca 7860 ttcggaccgc aaggaatcgg tcaatacact acatggcgtg atttcatatg cgcgattgct 7920 gatccccatg tgtatcactg gcaaactgtg atggacgaca ccgtcagtgc gtccgtcgcg 7980 caggctctcg atgagctgat gctttgggcc gaggactgcc ccgaagtccg gcacctcgtg 8040 cacgcggatt tcggctccaa caatgtcctg acggacaatg gccgcataac agcggtcatt 8100 gactggagcg aggcgatgtt cggggattcc caatacgagg tcgccaacat cttcttctgg 8160 aggccgtggt tggcttgtat ggagcagcag acgcgctact tcgagcggag gcatccggag 8220 cttgcaggat cgccgcggct ccgggcgtat atgctccgca ttggtcttga ccaactctat 8280 cagagcttgg ttgacggcaa tttcgatgat gcagcttggg cgcagggtcg atgcgacgca 8340 atcgtccgat ccggagccgg gactgtcggg cgtacacaaa tcgcccgcag aagcgcggcc 8400 gtctggaccg atggctgtgt agaagtactc gccgatagtg gaaaccgacg ccccagcact 8460 cgtccgaggg caaaggaaac tagtggcagc ggcgccacaa acttctctct gctaaagcaa 8520 gcaggtgatg ttgaagaaaa ccccgggcct ggcgcgccaa tgaatacact cgagatggac 8580 atcatcagcg tggctctgaa gaggcactcc accaaggctt tcgacgcttc caagaaactg 8640 acccctgaac aggccgagca gatcaagacc ctgctccagt acagccctag ctccaccaac 8700 agccagcctt ggcacttcat cgtggctagc accgaggaag gcaaagctag ggtggctaag 8760 agcgccgctg gcaactacgt gttcaacgag aggaagatgc tggatgctag ccacgtggtg 8820 gtgttctgcg ctaagaccgc catggacgat gtgtggctga agctggtggt ggatcaggaa 8880 gatgctgatg gcaggttcgc tacccctgaa gctaaggccg ctaacgacaa gggcaggaag 8940 ttcttcgccg acatgcacag gaaggatctg cacgatgatg ctgagtggat ggccaagcag 9000 gtgtacctga acgtgggcaa cttcctgctc ggcgtggctg ccctgggcct cgatgctgtg 9060 cccatcgaag gcttcgatgc tgctatcctg gatgccgagt tcggcctgaa ggagaaaggc 9120 tacaccagcc tggtggtggt gcctgtgggc caccacagcg tggaggactt caacgctacc 9180 ctgcctaaga gcaggctgcc ccagaacatc accctgaccg aggtgggccg gccaggctcg 9240 ggccagtgta ctaattatgc tctcttgaaa ttggctggag atgttgagag caacccaggt 9300 cccttaatta agatggtgag caagggcgag gaggataaca tggccatcat caaggagttc 9360 atgcgcttca aggtgcacat ggagggctcc gtgaacggcc acgagttcga gatcgagggc 9420 gagggcgagg gccgccccta cgagggcacc cagaccgcca agctgaaggt gaccaagggt 9480 ggccccctgc ccttcgcctg ggacatcctg tcccctcagt tcatgtacgg ctccaaggcc 9540 tacgtgaagc accccgccga catccccgac tacttgaagc tgtccttccc cgagggcttc 9600 aagtgggagc gcgtgatgaa cttcgaggac ggcggcgtgg tgaccgtgac ccaggactcc 9660 tccctgcagg acggcgagtt catctacaag gtgaagctgc gcggcaccaa cttcccctcc 9720 gacggccccg taatgcagaa gaagaccatg ggctgggagg cctcctccga gcggatgtac 9780 cccgaggacg gcgccctgaa gggcgagatc aagcagaggc tgaagctgaa ggacggcggc 9840 cactacgacg ctgaggtcaa gaccacctac aaggccaaga agcccgtgca gctgcccggc 9900 gcctacaacg tcaacatcaa gttggacatc acctcccaca acgaggacta caccatcgtg 9960 gaacagtacg aacgcgccga gggccgccac tccaccggcg gcatggacga gctgtacaag 10020 taattaatta aaagggcgaa ttcgacccag ctttcttgta caaagtggtt gatatccagc 10080 acagtggcgg ccgctcgagt ctagagggcc cgcggttcga aggtaagcct atccctaacc 10140 ctctcctcgg tctcgattct acgcgtaccg gttaggggcc cgtttaaacc cgctgatcag 10200 cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct 10260 tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc 10320 attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg 10380 aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg gctctagaag 10440 tcgacagtac taagctttga cagaaaagcc ccatccttag gcctcctcct tcctagtctc 10500 ctgatattgg gtctaacccc cacctcctgt taggcagatt ccttatctgg tgacacaccc 10560 ccatttcctg gagccatctc tctccttgcc agaacctcta aggtttgctt acgatggagc 10620 cagagaggat cctgggaggg agagcttggc agggggtggg agggaagggg gggatgcgtg 10680 acctgcccgg ttctcagtgg ccaccctgcg ctaccctctc ccagaacctg agctgctctg 10740 acgcggctgt ctggtgcgtt tcactgatcc tggtgctgca gcttccttac acttcccaag 10800 aggagaagca gtttggaaaa acaaaatcag aataagttgg tcctgagttc taactttggc 10860 tcttcacctt tctagtcccc aatttatatt gttcctccgt gcgtcagttt tacctgtgag 10920 ataaggccag tagccagccc cgtcctggca gggctgtggt gaggaggggg gtgtccgtgt 10980 ggaaaactcc ctttgtgaga atggtgcgtc ctaggtgttc accaggtcgt ggccgcctct 11040 actccctttc tctttctcca tccttctttc cttaaagagt ccccagtgct atctgggaca 11100 tattcctccg cccagagcag ggtcccgctt ccctaaggcc ctgctctggg cttctgggtt 11160 tgagtccttg gcaagcccag gagaggcgct caggcttccc tgtccccctt cctcgtccac 11220 catctcatgc ccctggctct cctgcccctt ccctacaggg gttcctggct ctgctctagc 11280 gatcgccaat tcgccctata gtgagtcgta ttacaattca ctggccgtcg ttttacaacg 11340 tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc cttgcagcac atcccccttt 11400 cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac agttgcgcag 11460 cctgaatggc gaatgggacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt 11520 tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt 11580 cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc gggggctccc 11640 tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg attagggtga 11700 tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga cgttggagtc 11760 cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc ctatctcggt 11820 ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa aaaatgagct 11880 gatttaacaa aaatttaacg cgaattttaa caaaatatta acgcttacaa tttaggtg 11938 <210> 206 <211> 11497 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 206 gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa 60 atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga 120 agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc 180 ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg 240 gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc 300 gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat 360 tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg 420 acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag 480 aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa 540 cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc 600 gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca 660 cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc 720 tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc 780 tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg 840 ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta 900 tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag 960 gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga 1020 ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc 1080 tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa 1140 agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa 1200 aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc 1260 cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt 1320 agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc 1380 tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac 1440 gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca 1500 gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg 1560 ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag 1620 gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt 1680 ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat 1740 ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc 1800 acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt 1860 gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag 1920 cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca 1980 gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga 2040 gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt 2100 gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca 2160 agctcgaaat taaccctcac taaagggaac aaaagctgtg ctttctctga ccagcattct 2220 ctcccctggg cctgtgccgc tttctgtctg cagcttgtgg cctgggtcac ctctacggct 2280 ggcccagatc cttccctgcc gcctccttca ggttccgtct tcctccactc cctcttcccc 2340 ttgctctctg ctgtgttgct gcccaaggat gctctttccg gagcacttcc ttctcggcgc 2400 tgcaccacgt gatgtcctct gagcggatcc tccccgtgtc tgggtcctct ccgggcatct 2460 ctcctccctc acccaacccc atgccgtctt cactcgctgg gttccctttt ccttctcctt 2520 ctggggcctg tgccatctct cgtttcttag gatggccttc tccgacggat gtctcccttg 2580 cgtcccgcct ccccttcttg taggcctgca tcatcaccgt ttttctggac aaccccaaag 2640 taccccgtct ccctggcttt agccacctct ccatcctctt gctttctttg cctggacacc 2700 ccgttctcct gtggattcgg gtcacctctc actcctttca tttgggcagc tcccctaccc 2760 cccttacctc tctagtctgt gctagctctt ccagccccct gtcatggcat cttccagggg 2820 tccgagagct cagctagtct tcttcctcca acccgggccc ctatgtccac ttcaggacag 2880 catgtttgct gcctccaggg atcctgtgtc cccgagctgg gaccacctta tattcccagg 2940 gccggttaat gtggctctgg ttctgggtac ttttatctgt cccctccacc ccacagtggg 3000 gcaagcttct gacctcttct cttcctccca cagggcctcg agagatctgg cagcggagag 3060 ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc taggctcgag 3120 ggtaccatga ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg 3180 ctattcggct atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg 3240 ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat 3300 gaactgcagg acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca 3360 gctgtgctcg acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg 3420 gggcaggatc tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat 3480 gcaatgcggc ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa 3540 catcgcatcg agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg 3600 gacgaagagc atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgcgcatg 3660 cccgacggcg aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg 3720 gaaaatggcc gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat 3780 caggacatag cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac 3840 cgcttcctcg tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc 3900 cttcttgacg agttcttctg agtttaaacc cgctgatcag cctcgactgt gccttctagt 3960 tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact 4020 cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat 4080 tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc 4140 aggcatgctg gggatgcggt gggctctatg ggctagcggt ggcggcctcg acattgatta 4200 ttgactagta gatctggcgc gccgcctttt tacggttcct ggccttttgc tggccttttg 4260 ctcacatgtc acgtgaggcc ttaacgtctc gccctttggt ctccccctct taagtaccac 4320 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 4380 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 4440 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 4500 tttgtccaaa ctcatcggct agcttacccg gggagcatgt caaggtcaaa atcgtcaaga 4560 gcgtcagcag gcagcatatc aaggtcaaag tcgtcaaggg catcggctgg gagcatgtct 4620 aagtcaaaat cgtcaagggc gtcggtcggc ccgccgcttt cgcactttag ctgtttctcc 4680 aggccacata tgattagttc caggccgaaa aggaaggcag gttcggctcc ctgccggtcg 4740 aacagctcaa ttgcttgtct cagaagtggg ggcatagaat cggtggtagg tgtctctctt 4800 tcctcttttg ctacttgatg ctcctgttcc tccaatacgc agcccagtgt aaagtggccc 4860 acggcggaca gagcgtacag tgcgttctcc agggagaagc cttgctgaca caggaacgcg 4920 agctgatttt ccagggtttc gtactgtttc tctgttgggc gggtgccgag atgcacttta 4980 gccccgtcgc gatgtgagag gagagcacag cggtatgact tggcgttgtt ccgcagaaag 5040 tcttgccatg actcgccttc cagggggcag aagtgggtat gatgcctgtc cagcatctcg 5100 attggcaggg catcgagcag ggcccgcttg ttcttcacgt gccagtacag ggtaggctgc 5160 tcaactccca gcttttgagc gagtttcctt gtcgtcaggc cttcgatacc gacaccattg 5220 agtaattcca gagctccgtt tatgactttg ctcttgtcca gtctagacat tggaccaggg 5280 ttttcttcaa catcaccaca agtgaggaga gaacctctac cttcggcacc gggatttcgg 5340 gtatatttga gtggaatgag ttcttcaatc gtagttttga ctaacttgcc attcatttct 5400 attaacacaa aacaatctgg tgcatagtct gaaatcaact ccctacacat accacaagga 5460 cttaccactc gaatacttct atctacttcg tcagaataag ggtgtctaac agctacaatc 5520 gtgtcaaaat ccttttgtcc attcgaaact gcactaccaa tcgcaatggc ttctgcacaa 5580 acagttactc gtcctatata cgcttcaata tgtactgccg aaatgatttc tcctgttttc 5640 gtacgaattg ccgctcccac atgatgttta ttatcctcat aaagcattgt aatcttctct 5700 gtcgctactt ctactaattc tagatcctgt tgagaaatgt taaatgtttt catggtggcg 5760 gcactagtaa gggcgaattc ggagcctgct tttttgtaca aacttgttga tatctgcaga 5820 attccaccac actggactag tggatccgag ctcggtacca agcttcttca cgacacctga 5880 aatggaagaa aaaaactttg aaccactgtc tgaggcttga gaatgaacca agatccaaac 5940 tcaaaaaggg caaattccaa ggagaattac atcaagtgcc aagctggcct aacttcagtc 6000 tccacccact cagtgtgggg aaactccatc gcataaaacc cctcccccca acctaaagac 6060 gacgtactcc aaaagctcga gaactaatcg aggtgcctgg acggcgcccg gtactccgtg 6120 gagtcacatg aagcgacggc tgaggacgga aaggcccttt tcctttgtgt gggtgactca 6180 cccgcccgct ctcccgagcg ccgcgtcctc cattttgagc tccctgcagc agggccggga 6240 agcggccatc tttccgctca cgcaactggt gccgaccggg ccagccttgc cgcccagggc 6300 ggggcgatac acggcggcgc gaggccaggc accagagcag gccggccagc ttgagactac 6360 ccccgtccga ttctcggtgg ccgcgctcgc aggccccgcc tcgccgaaca tgtgcgctgg 6420 gacgcacggg ccccgtcgcc gcccgcggcc ccaaaaaccg aaataccagt gtgcagatct 6480 tggcccgcat ttacaagact atcttgccag aaaaaaagcg tcgcagcagg tcatcaaaaa 6540 ttttaaatgg ctagagactt atcgaaagca gcgagacagg cgcgaaggtg ccaccagatt 6600 cgcacgcggc ggccccagcg cccaggccag gcctcaactc aagcacgagg cgaaggggct 6660 ccttaagcgc aaggcctcga actctcccac ccacttccaa cccgaagctc gggatcaaga 6720 atcacgtact gcagccaggt ggaagtaatt caaggcacgc aagggccata acccgtaaag 6780 aggccaggcc cgcgggaacc acacacggca cttacctgtg ttctggcggc aaacccgttg 6840 cgaaaaagaa cgttcacggc gactactgca cttatatacg gttctccccc accctcggga 6900 aaaaggcgga gccagtacac gacatcactt tcccagttta ccccgcgcca ccttctctag 6960 gcaccggttc aattgccgac ccctcccccc aacttctcgg ggactgtggg cgatgtgcgc 7020 tctgcccact gacgggcacc ggagcctcac gatcgatatg tcgagtttac tccctatcag 7080 tgatagagaa cgtatgtcga gtttactccc tatcagtgat agagaacgat gtcgagttta 7140 ctccctatca gtgatagaga acgtatgtcg agtttactcc ctatcagtga tagagaacgt 7200 atgtcgagtt tactccctat cagtgataga gaacgtatgt cgagtttatc cctatcagtg 7260 atagagaacg tatgtcgagt ttactcccta tcagtgatag agaacgtatg tcgaggtagg 7320 cgtgtacggt gggaggccta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg 7380 agaattggct aggcaccggt gacaagtttg tacaaaaaag caggctccga attcgccctt 7440 actagtgccg ccaccatgaa aaagcctgaa ctcaccgcga cgtctgtcga gaagtttctg 7500 atcgaaaagt tcgacagcgt ctccgacctg atgcagctct cggagggcga agaatctcgt 7560 gctttcagct tcgatgtagg agggcgtgga tatgtcctgc gggtaaatag ctgcgccgat 7620 ggtttctaca aagatcgtta tgtttatcgg cactttgcat cggccgcgct cccgattccg 7680 gaagtgcttg acattgggga atttagcgag agcctgacct attgcctttc atacgagacc 7740 gagatcctga ctgtcgagta cggattgctt cctatcggca aaatcgtgga gaagaggatt 7800 gaatgtaccg tctattcagt cgataataat gggaacatct acacacagcc cgtggctcaa 7860 tggcacgaca gaggagagca ggaagttttt gaatactgtc tcgaggacgg atccctcatc 7920 cgcgctacta aagatcataa gtttatgacc gtggacggcc agatgctgcc aattgacgaa 7980 atttttgaac gagagctgga tctgatgaga gtcgacaacc ttccaaacac tagtggcagc 8040 ggcgccacaa acttctctct gctaaagcaa gcaggtgatg ttgaagaaaa ccccgggcct 8100 ggcgcgccaa tgaatacact cgagatggac atcatcagcg tggctctgaa gaggcactcc 8160 accaaggctt tcgacgcttc caagaaactg acccctgaac aggccgagca gatcaagacc 8220 ctgctccagt acagccctag ctccaccaac agccagcctt ggcacttcat cgtggctagc 8280 accgaggaag gcaaagctag ggtggctaag agcgccgctg gcaactacgt gttcaacgag 8340 aggaagatgc tggatgctag ccacgtggtg gtgttctgcg ctaagaccgc catggacgat 8400 gtgtggctga agctggtggt ggatcaggaa gatgctgatg gcaggttcgc tacccctgaa 8460 gctaaggccg ctaacgacaa gggcaggaag ttcttcgccg acatgcacag gaaggatctg 8520 cacgatgatg ctgagtggat ggccaagcag gtgtacctga acgtgggcaa cttcctgctc 8580 ggcgtggctg ccctgggcct cgatgctgtg cccatcgaag gcttcgatgc tgctatcctg 8640 gatgccgagt tcggcctgaa ggagaaaggc tacaccagcc tggtggtggt gcctgtgggc 8700 caccacagcg tggaggactt caacgctacc ctgcctaaga gcaggctgcc ccagaacatc 8760 accctgaccg aggtgggccg gccaggctcg ggccagtgta ctaattatgc tctcttgaaa 8820 ttggctggag atgttgagag caacccaggt cccttaatta agatggtgag caagggcgag 8880 gagctgttca ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac 8940 aagttcagcg tgtccggcga gggcgagggc gatgccacct acggcaagct gaccctgaag 9000 ttcatctgca ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac caccctgacc 9060 tacggcgtgc agtgcttcag ccgctacccc gaccacatga agcagcacga cttcttcaag 9120 tccgccatgc ccgaaggcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac 9180 tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg 9240 aagggcatcg acttcaagga ggacggcaac atcctggggc acaagctgga gtacaactac 9300 aacagccaca acgtctatat catggccgac aagcagaaga acggcatcaa ggtgaacttc 9360 aagatccgcc acaacatcga ggacggcagc gtgcagctcg ccgaccacta ccagcagaac 9420 acccccatcg gcgacggccc cgtgctgctg cccgacaacc actacctgag cacccagtcc 9480 gccctgagca aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc 9540 gccgccggga tcactctcgg catggacgag ctgtacaagt aattaattaa gagggcgaat 9600 tcgacccagc tttcttgtac aaagtggttg atatccagca cagtggcggc cgctcgagtc 9660 tagagggccc gcggttcgaa ggtaagccta tccctaaccc tctcctcggt ctcgattcta 9720 cgcgtaccgg ttaggggccc gtttaaaccc gctgatcagc ctcgactgtg ccttctagtt 9780 gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc 9840 ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt 9900 ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca 9960 ggcatgctgg ggatgcggtg ggctctatgg ctctagaagt cgacagtact aagctttgac 10020 agaaaagccc catccttagg cctcctcctt cctagtctcc tgatattggg tctaaccccc 10080 acctcctgtt aggcagattc cttatctggt gacacacccc catttcctgg agccatctct 10140 ctccttgcca gaacctctaa ggtttgctta cgatggagcc agagaggatc ctgggaggga 10200 gagcttggca gggggtggga gggaaggggg ggatgcgtga cctgcccggt tctcagtggc 10260 caccctgcgc taccctctcc cagaacctga gctgctctga cgcggctgtc tggtgcgttt 10320 cactgatcct ggtgctgcag cttccttaca cttcccaaga ggagaagcag tttggaaaaa 10380 caaaatcaga ataagttggt cctgagttct aactttggct cttcaccttt ctagtcccca 10440 atttatattg ttcctccgtg cgtcagtttt acctgtgaga taaggccagt agccagcccc 10500 gtcctggcag ggctgtggtg aggagggggg tgtccgtgtg gaaaactccc tttgtgagaa 10560 tggtgcgtcc taggtgttca ccaggtcgtg gccgcctcta ctccctttct ctttctccat 10620 ccttctttcc ttaaagagtc cccagtgcta tctgggacat attcctccgc ccagagcagg 10680 gtcccgcttc cctaaggccc tgctctgggc ttctgggttt gagtccttgg caagcccagg 10740 agaggcgctc aggcttccct gtcccccttc ctcgtccacc atctcatgcc cctggctctc 10800 ctgccccttc cctacagggg ttcctggctc tgctctagcg atcgccaatt cgccctatag 10860 tgagtcgtat tacaattcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg 10920 cgttacccaa cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga 10980 agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatgggacgc 11040 gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac 11100 acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt 11160 cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc 11220 tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc 11280 gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact 11340 cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg 11400 gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc 11460 gaattttaac aaaatattaa cgcttacaat ttaggtg 11497 <210> 207 <211> 11779 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 207 gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa 60 atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga 120 agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc 180 ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg 240 gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc 300 gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat 360 tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg 420 acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag 480 aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa 540 cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc 600 gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca 660 cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc 720 tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc 780 tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg 840 ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta 900 tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag 960 gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga 1020 ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc 1080 tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa 1140 agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa 1200 aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc 1260 cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt 1320 agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc 1380 tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac 1440 gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca 1500 gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg 1560 ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag 1620 gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt 1680 ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat 1740 ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc 1800 acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt 1860 gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag 1920 cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca 1980 gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga 2040 gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt 2100 gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca 2160 agctcgaaat taaccctcac taaagggaac aaaagctgtg ctttctctga ccagcattct 2220 ctcccctggg cctgtgccgc tttctgtctg cagcttgtgg cctgggtcac ctctacggct 2280 ggcccagatc cttccctgcc gcctccttca ggttccgtct tcctccactc cctcttcccc 2340 ttgctctctg ctgtgttgct gcccaaggat gctctttccg gagcacttcc ttctcggcgc 2400 tgcaccacgt gatgtcctct gagcggatcc tccccgtgtc tgggtcctct ccgggcatct 2460 ctcctccctc acccaacccc atgccgtctt cactcgctgg gttccctttt ccttctcctt 2520 ctggggcctg tgccatctct cgtttcttag gatggccttc tccgacggat gtctcccttg 2580 cgtcccgcct ccccttcttg taggcctgca tcatcaccgt ttttctggac aaccccaaag 2640 taccccgtct ccctggcttt agccacctct ccatcctctt gctttctttg cctggacacc 2700 ccgttctcct gtggattcgg gtcacctctc actcctttca tttgggcagc tcccctaccc 2760 cccttacctc tctagtctgt gctagctctt ccagccccct gtcatggcat cttccagggg 2820 tccgagagct cagctagtct tcttcctcca acccgggccc ctatgtccac ttcaggacag 2880 catgtttgct gcctccaggg atcctgtgtc cccgagctgg gaccacctta tattcccagg 2940 gccggttaat gtggctctgg ttctgggtac ttttatctgt cccctccacc ccacagtggg 3000 gcaagcttct gacctcttct cttcctccca cagggcctcg agagatctgg cagcggagag 3060 ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc taggctcgag 3120 ggtaccatga ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg 3180 ctattcggct atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg 3240 ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat 3300 gaactgcagg acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca 3360 gctgtgctcg acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg 3420 gggcaggatc tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat 3480 gcaatgcggc ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa 3540 catcgcatcg agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg 3600 gacgaagagc atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgcgcatg 3660 cccgacggcg aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg 3720 gaaaatggcc gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat 3780 caggacatag cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac 3840 cgcttcctcg tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc 3900 cttcttgacg agttcttctg agtttaaacc cgctgatcag cctcgactgt gccttctagt 3960 tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact 4020 cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat 4080 tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc 4140 aggcatgctg gggatgcggt gggctctatg ggctagcggt ggcggcctcg acattgatta 4200 ttgactagta gatctggcgc gccgcctttt tacggttcct ggccttttgc tggccttttg 4260 ctcacatgtc acgtgaggcc ttaacgtctc gccctttggt ctccccctct taagtaccac 4320 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 4380 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 4440 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 4500 tttgtccaaa ctcatcggct agcttacccg gggagcatgt caaggtcaaa atcgtcaaga 4560 gcgtcagcag gcagcatatc aaggtcaaag tcgtcaaggg catcggctgg gagcatgtct 4620 aagtcaaaat cgtcaagggc gtcggtcggc ccgccgcttt cgcactttag ctgtttctcc 4680 aggccacata tgattagttc caggccgaaa aggaaggcag gttcggctcc ctgccggtcg 4740 aacagctcaa ttgcttgtct cagaagtggg ggcatagaat cggtggtagg tgtctctctt 4800 tcctcttttg ctacttgatg ctcctgttcc tccaatacgc agcccagtgt aaagtggccc 4860 acggcggaca gagcgtacag tgcgttctcc agggagaagc cttgctgaca caggaacgcg 4920 agctgatttt ccagggtttc gtactgtttc tctgttgggc gggtgccgag atgcacttta 4980 gccccgtcgc gatgtgagag gagagcacag cggtatgact tggcgttgtt ccgcagaaag 5040 tcttgccatg actcgccttc cagggggcag aagtgggtat gatgcctgtc cagcatctcg 5100 attggcaggg catcgagcag ggcccgcttg ttcttcacgt gccagtacag ggtaggctgc 5160 tcaactccca gcttttgagc gagtttcctt gtcgtcaggc cttcgatacc gacaccattg 5220 agtaattcca gagctccgtt tatgactttg ctcttgtcca gtctagacat tggaccaggg 5280 ttttcttcaa catcaccaca agtgaggaga gaacctctac cttcggcacc gggatttcgg 5340 gtatatttga gtggaatgag ttcttcaatc gtagttttga ctaacttgcc attcatttct 5400 attaacacaa aacaatctgg tgcatagtct gaaatcaact ccctacacat accacaagga 5460 cttaccactc gaatacttct atctacttcg tcagaataag ggtgtctaac agctacaatc 5520 gtgtcaaaat ccttttgtcc attcgaaact gcactaccaa tcgcaatggc ttctgcacaa 5580 acagttactc gtcctatata cgcttcaata tgtactgccg aaatgatttc tcctgttttc 5640 gtacgaattg ccgctcccac atgatgttta ttatcctcat aaagcattgt aatcttctct 5700 gtcgctactt ctactaattc tagatcctgt tgagaaatgt taaatgtttt catggtggcg 5760 gcactagtaa gggcgaattc ggagcctgct tttttgtaca aacttgttga tatctgcaga 5820 attccaccac actggactag tggatccgag ctcggtacca agcttcttca cgacacctga 5880 aatggaagaa aaaaactttg aaccactgtc tgaggcttga gaatgaacca agatccaaac 5940 tcaaaaaggg caaattccaa ggagaattac atcaagtgcc aagctggcct aacttcagtc 6000 tccacccact cagtgtgggg aaactccatc gcataaaacc cctcccccca acctaaagac 6060 gacgtactcc aaaagctcga gaactaatcg aggtgcctgg acggcgcccg gtactccgtg 6120 gagtcacatg aagcgacggc tgaggacgga aaggcccttt tcctttgtgt gggtgactca 6180 cccgcccgct ctcccgagcg ccgcgtcctc cattttgagc tccctgcagc agggccggga 6240 agcggccatc tttccgctca cgcaactggt gccgaccggg ccagccttgc cgcccagggc 6300 ggggcgatac acggcggcgc gaggccaggc accagagcag gccggccagc ttgagactac 6360 ccccgtccga ttctcggtgg ccgcgctcgc aggccccgcc tcgccgaaca tgtgcgctgg 6420 gacgcacggg ccccgtcgcc gcccgcggcc ccaaaaaccg aaataccagt gtgcagatct 6480 tggcccgcat ttacaagact atcttgccag aaaaaaagcg tcgcagcagg tcatcaaaaa 6540 ttttaaatgg ctagagactt atcgaaagca gcgagacagg cgcgaaggtg ccaccagatt 6600 cgcacgcggc ggccccagcg cccaggccag gcctcaactc aagcacgagg cgaaggggct 6660 ccttaagcgc aaggcctcga actctcccac ccacttccaa cccgaagctc gggatcaaga 6720 atcacgtact gcagccaggt ggaagtaatt caaggcacgc aagggccata acccgtaaag 6780 aggccaggcc cgcgggaacc acacacggca cttacctgtg ttctggcggc aaacccgttg 6840 cgaaaaagaa cgttcacggc gactactgca cttatatacg gttctccccc accctcggga 6900 aaaaggcgga gccagtacac gacatcactt tcccagttta ccccgcgcca ccttctctag 6960 gcaccggttc aattgccgac ccctcccccc aacttctcgg ggactgtggg cgatgtgcgc 7020 tctgcccact gacgggcacc ggagcctcac gatcgatatg tcgagtttac tccctatcag 7080 tgatagagaa cgtatgtcga gtttactccc tatcagtgat agagaacgat gtcgagttta 7140 ctccctatca gtgatagaga acgtatgtcg agtttactcc ctatcagtga tagagaacgt 7200 atgtcgagtt tactccctat cagtgataga gaacgtatgt cgagtttatc cctatcagtg 7260 atagagaacg tatgtcgagt ttactcccta tcagtgatag agaacgtatg tcgaggtagg 7320 cgtgtacggt gggaggccta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg 7380 agaattggct aggcaccggt gacaagtttg tacaaaaaag caggctccga attcgccctt 7440 actagtgccg ccaccatgat taagatcgct acgcggaagt acctggggaa acagaacgtc 7500 tacgacatag gtgtggagcg cgatcacaac tttgctctga aaaatggatt tatcgccagc 7560 aactgcatct cccgccgtgc acagggtgtc acgttgcaag acctgcctga aaccgaactg 7620 cccgctgttc tgcagccggt cgcggaggcc atggatgcga tcgctgcggc cgatcttagc 7680 cagacgagcg ggttcggccc attcggaccg caaggaatcg gtcaatacac tacatggcgt 7740 gatttcatat gcgcgattgc tgatccccat gtgtatcact ggcaaactgt gatggacgac 7800 accgtcagtg cgtccgtcgc gcaggctctc gatgagctga tgctttgggc cgaggactgc 7860 cccgaagtcc ggcacctcgt gcacgcggat ttcggctcca acaatgtcct gacggacaat 7920 ggccgcataa cagcggtcat tgactggagc gaggcgatgt tcggggattc ccaatacgag 7980 gtcgccaaca tcttcttctg gaggccgtgg ttggcttgta tggagcagca gacgcgctac 8040 ttcgagcgga ggcatccgga gcttgcagga tcgccgcggc tccgggcgta tatgctccgc 8100 attggtcttg accaactcta tcagagcttg gttgacggca atttcgatga tgcagcttgg 8160 gcgcagggtc gatgcgacgc aatcgtccga tccggagccg ggactgtcgg gcgtacacaa 8220 atcgcccgca gaagcgcggc cgtctggacc gatggctgtg tagaagtact cgccgatagt 8280 ggaaaccgac gccccagcac tcgtccgagg gcaaaggaaa ctagtggcag cggcgccaca 8340 aacttctctc tgctaaagca agcaggtgat gttgaagaaa accccgggcc tggcgcgcca 8400 atgaatacac tcgagatgga catcatcagc gtggctctga agaggcactc caccaaggct 8460 ttcgacgctt ccaagaaact gacccctgaa caggccgagc agatcaagac cctgctccag 8520 tacagcccta gctccaccaa cagccagcct tggcacttca tcgtggctag caccgaggaa 8580 ggcaaagcta gggtggctaa gagcgccgct ggcaactacg tgttcaacga gaggaagatg 8640 ctggatgcta gccacgtggt ggtgttctgc gctaagaccg ccatggacga tgtgtggctg 8700 aagctggtgg tggatcagga agatgctgat ggcaggttcg ctacccctga agctaaggcc 8760 gctaacgaca agggcaggaa gttcttcgcc gacatgcaca ggaaggatct gcacgatgat 8820 gctgagtgga tggccaagca ggtgtacctg aacgtgggca acttcctgct cggcgtggct 8880 gccctgggcc tcgatgctgt gcccatcgaa ggcttcgatg ctgctatcct ggatgccgag 8940 ttcggcctga aggagaaagg ctacaccagc ctggtggtgg tgcctgtggg ccaccacagc 9000 gtggaggact tcaacgctac cctgcctaag agcaggctgc cccagaacat caccctgacc 9060 gaggtgggcc ggccaggctc gggccagtgt actaattatg ctctcttgaa attggctgga 9120 gatgttgaga gcaacccagg tcccttaatt aagatggtga gcaagggcga ggaggataac 9180 atggccatca tcaaggagtt catgcgcttc aaggtgcaca tggagggctc cgtgaacggc 9240 cacgagttcg agatcgaggg cgagggcgag ggccgcccct acgagggcac ccagaccgcc 9300 aagctgaagg tgaccaaggg tggccccctg cccttcgcct gggacatcct gtcccctcag 9360 ttcatgtacg gctccaaggc ctacgtgaag caccccgccg acatccccga ctacttgaag 9420 ctgtccttcc ccgagggctt caagtgggag cgcgtgatga acttcgagga cggcggcgtg 9480 gtgaccgtga cccaggactc ctccctgcag gacggcgagt tcatctacaa ggtgaagctg 9540 cgcggcacca acttcccctc cgacggcccc gtaatgcaga agaagaccat gggctgggag 9600 gcctcctccg agcggatgta ccccgaggac ggcgccctga agggcgagat caagcagagg 9660 ctgaagctga aggacggcgg ccactacgac gctgaggtca agaccaccta caaggccaag 9720 aagcccgtgc agctgcccgg cgcctacaac gtcaacatca agttggacat cacctcccac 9780 aacgaggact acaccatcgt ggaacagtac gaacgcgccg agggccgcca ctccaccggc 9840 ggcatggacg agctgtacaa gtaattaatt aaaagggcga attcgaccca gctttcttgt 9900 acaaagtggt tgatatccag cacagtggcg gccgctcgag tctagagggc ccgcggttcg 9960 aaggtaagcc tatccctaac cctctcctcg gtctcgattc tacgcgtacc ggttaggggc 10020 ccgtttaaac ccgctgatca gcctcgactg tgccttctag ttgccagcca tctgttgttt 10080 gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat 10140 aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg 10200 tggggcagga cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg 10260 tgggctctat ggctctagaa gtcgacagta ctaagctttg acagaaaagc cccatcctta 10320 ggcctcctcc ttcctagtct cctgatattg ggtctaaccc ccacctcctg ttaggcagat 10380 tccttatctg gtgacacacc cccatttcct ggagccatct ctctccttgc cagaacctct 10440 aaggtttgct tacgatggag ccagagagga tcctgggagg gagagcttgg cagggggtgg 10500 gagggaaggg ggggatgcgt gacctgcccg gttctcagtg gccaccctgc gctaccctct 10560 cccagaacct gagctgctct gacgcggctg tctggtgcgt ttcactgatc ctggtgctgc 10620 agcttcctta cacttcccaa gaggagaagc agtttggaaa aacaaaatca gaataagttg 10680 gtcctgagtt ctaactttgg ctcttcacct ttctagtccc caatttatat tgttcctccg 10740 tgcgtcagtt ttacctgtga gataaggcca gtagccagcc ccgtcctggc agggctgtgg 10800 tgaggagggg ggtgtccgtg tggaaaactc cctttgtgag aatggtgcgt cctaggtgtt 10860 caccaggtcg tggccgcctc tactcccttt ctctttctcc atccttcttt ccttaaagag 10920 tccccagtgc tatctgggac atattcctcc gcccagagca gggtcccgct tccctaaggc 10980 cctgctctgg gcttctgggt ttgagtcctt ggcaagccca ggagaggcgc tcaggcttcc 11040 ctgtccccct tcctcgtcca ccatctcatg cccctggctc tcctgcccct tccctacagg 11100 ggttcctggc tctgctctag cgatcgccaa ttcgccctat agtgagtcgt attacaattc 11160 actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc aacttaatcg 11220 ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc gcaccgatcg 11280 cccttcccaa cagttgcgca gcctgaatgg cgaatgggac gcgccctgta gcggcgcatt 11340 aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc 11400 gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca 11460 agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc 11520 caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt 11580 tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac 11640 aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc 11700 ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt 11760 aacgcttaca atttaggtg 11779 <210> 208 <211> 9330 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 208 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccacca tgaaaaagcc tgaactcacc 660 gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 720 ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc 780 ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt 840 gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaatttag cgagagcctg 900 acctattgcc tttcatacga gaccgagatc ctgactgtcg agtacggatt gcttcctatc 960 ggcaaaatcg tggagaagag gattgaatgt accgtctatt cagtcgataa taatgggaac 1020 atctacacac agcccgtggc tcaatggcac gacagaggag agcaggaagt ttttgaatac 1080 tgtctcgagg acggatccct catccgcgct actaaagatc ataagtttat gaccgtggac 1140 ggccagatgc tgccaattga cgaaattttt gaacgagagc tggatctgat gagagtcgac 1200 aaccttccaa acggtggagg ggggtcaggc tctgcgcagc tggaaaagga gcttcaagcc 1260 ctcgaaaaaa agttggccca gctcgagtgg gagaaccagg ctctggagaa agaactggcc 1320 cagtgattaa ttaagaattc gacccagctt tcttgtacaa agtggttggt aagcctatcc 1380 ctaaccctct cctcggtctc gattctacgt agtaatgagc tagcagtctc gaggttaacg 1440 aattccgccc cccccctaac gttactggcc gaagccgctt ggaataaggc cggtgtgcgc 1500 ttgtctatat gttattttcc accatattgc cgtcttttgg caatgtgagg gcccggaaac 1560 ctggccctgt cttcttgacg agcattccta ggggtctttc ccctctcgcc aaaggaatgc 1620 aaggtctgtt gaatgtcgtg aaggaagcag ttcctctgga agcttcttga agacaaacaa 1680 cgtctgtagc gaccctttgc aggcagcgga accccccacc tggcgacagg tgcccctgcg 1740 gccaaaagcc acgtgtataa gatacacctg caaaggcggc acaaccccag tgccacgttg 1800 tgagttggat agttgtggaa agagtcaaat ggctctcctc aagcgtattc aacaaggggc 1860 tgaaggatgc ccagaaggta ccccattgta tgggatctga tctggggcct cggtgcacat 1920 gctttacatg tgtttagtcg aggttaaaaa aacgtctagg ccccccgaac cacggggacg 1980 tggttttcct ttgaaaaaca cgataatacc atggccatga gcgagctgat taaggagaac 2040 atgcacatga agctgtacat ggagggcacc gtggacaacc atcacttcaa gtgcacatcc 2100 gagggcgaag gcaagcccta cgagggcacc cagaccatga gaatcaaggt ggtcgagggc 2160 ggccctctcc ccttcgcctt cgacatcctg gctactagct tcctctacgg cagcaagacc 2220 ttcatcaacc acacccaggg catccccgac ttcttcaagc agtccttccc tgagggcttc 2280 acatgggaga gagtcaccac atacgaagac gggggcgtgc tgaccgctac ccaggacacc 2340 agcctccagg acggctgcct catctacaac gtcaagatca gaggggtgaa cttcacatcc 2400 aacggccctg tgatgcagaa gaaaacactc ggctgggagg ccttcaccga gacgctgtac 2460 cccgctgacg gcggcctgga aggcagaaac gacatggccc tgaagctcgt gggcgggagc 2520 catctgatcg caaacatcaa gaccacatat agatccaaga aacccgctaa gaacctcaag 2580 atgcctggcg tctactatgt ggactacaga ctggaaagaa tcaaggaggc caacaacgag 2640 acctacgtcg agcagcacga ggtggcagtg gccagatact gcgacctccc tagcaaactg 2700 gggcacaagc ttaattaaca ccggtggcgc gttaagtcga caatcaacct ctggattaca 2760 aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat 2820 acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct 2880 ccttgtataa atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac 2940 gtggcgtggt gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca 3000 cctgtcagct cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca 3060 tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg 3120 tggtgttgtc ggggaaatca tcgtcctttc cttggctgct cgcctgtgtt gccacctgga 3180 ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt 3240 cccgcggcct gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga 3300 gtcggatctc cctttgggcc gcctccccgc gtcgacttta agaccaatga cttacaaggc 3360 agctgtagat cttagccact ttttaaaaga aaagggggga ctggaagggc taattcactc 3420 ccaacgaaga caagatctgc tttttgcttg tactgggtct ctctggttag accagatctg 3480 agcctgggag ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc 3540 ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac tctggtaact agagatccct 3600 cagacccttt tagtcagtgt ggaaaatctc tagcagtacg tatagtagtt catgtcatct 3660 tattattcag tatttataac ttgcaaagaa atgaatatca gagagtgaga ggaacttgtt 3720 tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc 3780 atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt 3840 ctggctctag ctatcccgcc cctaactccg cccatcccgc ccctaactcc gcccagttcc 3900 gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc cgaggccgcc 3960 tcggcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct agggacgtac 4020 ccaattcgcc ctatagtgag tcgtattacg cgcgctcact ggccgtcgtt ttacaacgtc 4080 gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg 4140 ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc 4200 tgaatggcga atgggacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta 4260 cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc 4320 cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt 4380 tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg 4440 gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca 4500 cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct 4560 attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga 4620 tttaacaaaa atttaacgcg aattttaaca aaatattaac gcttacaatt taggtggcac 4680 ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat 4740 gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag 4800 tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc 4860 tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc 4920 acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc 4980 cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc 5040 ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt 5100 ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt 5160 atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat 5220 cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct 5280 tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat 5340 gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc 5400 ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg 5460 ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc 5520 tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta 5580 cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc 5640 ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga 5700 tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat 5760 gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat 5820 caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa 5880 accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa 5940 ggtaactggc ttcagcagag cgcagatacc aaatactgtt cttctagtgt agccgtagtt 6000 aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt 6060 accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata 6120 gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt 6180 ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac 6240 gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga 6300 gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg 6360 ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa 6420 aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat 6480 gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc 6540 tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga 6600 agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg 6660 gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta 6720 gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta tgttgtgtgg 6780 aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt acgccaagcg 6840 cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagcttaat gtagtcttat 6900 gcaatactct tgtagtcttg caacatggta acgatgagtt agcaacatgc cttacaagga 6960 gagaaaaagc accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg tgccttatta 7020 ggaaggcaac agacgggtct gacatggatt ggacgaacca ctgaattgcc gcattgcaga 7080 gatattgtat ttaagtgcct agctcgatac ataaacgggt ctctctggtt agaccagatc 7140 tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg 7200 ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc 7260 ctcagaccct tttagtcagt gtggaaaatc tctagcagtg gcgcccgaac agggacttga 7320 aagcgaaagg gaaaccagag gagctctctc gacgcaggac tcggcttgct gaagcgcgca 7380 cggcaagagg cgaggggcgg cgactggtga gtacgccaaa aattttgact agcggaggct 7440 agaaggagag agatgggtgc gagagcgtca gtattaagcg ggggagaatt agatcgcgat 7500 gggaaaaaat tcggttaagg ccagggggaa agaaaaaata taaattaaaa catatagtat 7560 gggcaagcag ggagctagaa cgattcgcag ttaatcctgg cctgttagaa acatcagaag 7620 gctgtagaca aatactggga cagctacaac catcccttca gacaggatca gaagaactta 7680 gatcattata taatacagta gcaaccctct attgtgtgca tcaaaggata gagataaaag 7740 acaccaagga agctttagac aagatagagg aagagcaaaa caaaagtaag accaccgcac 7800 agcaagcggc cgctgatctt cagacctgga ggaggagata tgagggacaa ttggagaagt 7860 gaattatata aatataaagt agtaaaaatt gaaccattag gagtagcacc caccaaggca 7920 aagagaagag tggtgcagag agaaaaaaga gcagtgggaa taggagcttt gttccttggg 7980 ttcttgggag cagcaggaag cactatgggc gcagcgtcaa tgacgctgac ggtacaggcc 8040 agacaattat tgtctggtat agtgcagcag cagaacaatt tgctgagggc tattgaggcg 8100 caacagcatc tgttgcaact cacagtctgg ggcatcaagc agctccaggc aagaatcctg 8160 gctgtggaaa gatacctaaa ggatcaacag ctcctgggga tttggggttg ctctggaaaa 8220 ctcatttgca ccactgctgt gccttggaat gctagttgga gtaataaatc tctggaacag 8280 atttggaatc acacgacctg gatggagtgg gacagagaaa ttaacaatta cacaagctta 8340 atacactcct taattgaaga atcgcaaaac cagcaagaaa agaatgaaca agaattattg 8400 gaattagata aatgggcaag tttgtggaat tggtttaaca taacaaattg gctgtggtat 8460 ataaaattat tcataatgat agtaggaggc ttggtaggtt taagaatagt ttttgctgta 8520 ctttctatag tgaatagagt taggcaggga tattcaccat tatcgtttca gacccacctc 8580 ccaaccccga ggggaccctt gcgccttttc caaggcagcc ctgggtttgc gcagggacgc 8640 ggctgctctg ggcgtggttc cgggaaacgc agcggcgccg accctgggtc tcgcacattc 8700 ttcacgtccg ttcgcagcgt cacccggatc ttcgccgcta cccttgtggg ccccccggcg 8760 acgcttcctg ctccgcccct aagtcgggaa ggttccttgc ggttcgcggc gtgccggacg 8820 tgacaaacgg aagccgcacg tctcactagt accctcgcag acggacagcg ccagggagca 8880 atggcagcgc gccgaccgcg atgggctgtg gccaatagcg gctgctcagc agggcgcgcc 8940 gagagcagcg gccgggaagg ggcggtgcgg gaggcggggt gtggggcggt agtgtgggcc 9000 ctgttcctgc ccgcgcggtg ttccgcattc tgcaagcctc cggagcgcac gtcggcagtc 9060 ggctccctcg ttgaccgaat caccgacctc tctccccagg gggtacccag ctgtctagag 9120 aattctagat cttgagacaa atggcagtat tcatccacaa ttttaaaaga aaagggggga 9180 ttggggggta cagtgcaggg gaaagaatag tagacataat agcaacagac atacaaacta 9240 aagaattaca aaaacaaatt acaaaaattc aaaattttcg ggtttattac agggacagca 9300 gagatccact ttggcgccgg ctcgaggggg 9330 <210> 209 <211> 228 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 209 Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe Leu Ile 1 5 10 15 Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 20 25 30 Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 35 40 45 Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 50 55 60 Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 65 70 75 80 Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Leu Ser Tyr Glu Thr Glu 85 90 95 Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu 100 105 110 Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile 115 120 125 Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val 130 135 140 Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp 145 150 155 160 His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile 165 170 175 Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn Gly 180 185 190 Gly Gly Gly Ser Gly Ser Ala Gln Leu Glu Lys Glu Leu Gln Ala Leu 195 200 205 Glu Lys Lys Leu Ala Gln Leu Glu Trp Glu Asn Gln Ala Leu Glu Lys 210 215 220 Glu Leu Ala Gln 225 <210> 210 <211> 9534 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 210 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggctca actgaagaag 660 aaactccagg ccaataagaa agaactggca cagctgaagt ggaagctgca ggcactgaaa 720 aagaagctgg cacagggcgg aggaggctca ggcagtatga ttaagatcgc tacgcggaag 780 tacctgggga aacagaacgt ctacgacata ggtgtgggcg agccccacaa ctttgctctg 840 aaaaatggat ttatcgccag caactgcatc tcccgccgtg cacagggtgt cacgttgcaa 900 gacctgcctg aaaccgaact gcccgctgtt ctgcagccgg tcgcggaggc catggatgcg 960 atcgctgcgg ccgatcttag ccagacgagc gggttcggcc cattcggacc gcaaggaatc 1020 ggtcaataca ctacatggcg tgatttcata tgcgcgattg ctgatcccca tgtgtatcac 1080 tggcaaactg tgatggacga caccgtcagt gcgtccgtcg cgcaggctct cgatgagctg 1140 atgctttggg ccgaggactg ccccgaagtc cggcacctcg tgcacgcgga tttcggctgt 1200 atcagtggcg actccctgat ctcactcgca agcactggaa agcgagttag catcaaggac 1260 ttgctggacg aaaaggattt cgaaatttgg gcaatcaatg agcagaccat gaaactggag 1320 tctgcaaagg tgtcccgggt gttttgcacg ggtaagaagc ttgtttatat ccttaaaact 1380 agactgggcc ggacgatcaa agccaccgcg aaccacagat tcttgacaat cgacgggtgg 1440 aaacggctgg acgaactgag cttgaaggag cacatcgccc ttcctcggaa gctcgagtca 1500 tcttccctgc agctgtgatt aattaagaat tcgacccagc tttcttgtac aaagtggttg 1560 gtaagcctat ccctaaccct ctcctcggtc tcgattctac gtagtaatga gctagcagtc 1620 tcgaggttaa cgaattccgc ccccccccta acgttactgg ccgaagccgc ttggaataag 1680 gccggtgtgc gcttgtctat atgttatttt ccaccatatt gccgtctttt ggcaatgtga 1740 gggcccggaa acctggccct gtcttcttga cgagcattcc taggggtctt tcccctctcg 1800 ccaaaggaat gcaaggtctg ttgaatgtcg tgaaggaagc agttcctctg gaagcttctt 1860 gaagacaaac aacgtctgta gcgacccttt gcaggcagcg gaacccccca cctggcgaca 1920 ggtgcccctg cggccaaaag ccacgtgtat aagatacacc tgcaaaggcg gcacaacccc 1980 agtgccacgt tgtgagttgg atagttgtgg aaagagtcaa atggctctcc tcaagcgtat 2040 tcaacaaggg gctgaaggat gcccagaagg taccccattg tatgggatct gatctggggc 2100 ctcggtgcac atgctttaca tgtgtttagt cgaggttaaa aaaacgtcta ggccccccga 2160 accacgggga cgtggttttc ctttgaaaaa cacgataata ccatggtgag caagggcgag 2220 gagctgttca ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac 2280 aagttcagcg tgtccggcga gggcgagggc gatgccacct acggcaagct gaccctgaag 2340 ttcatctgca ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac caccctgacc 2400 tacggcgtgc agtgcttcag ccgctacccc gaccacatga agcagcacga cttcttcaag 2460 tccgccatgc ccgaaggcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac 2520 tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg 2580 aagggcatcg acttcaagga ggacggcaac atcctggggc acaagctgga gtacaactac 2640 aacagccaca acgtctatat catggccgac aagcagaaga acggcatcaa ggtgaacttc 2700 aagatccgcc acaacatcga ggacggcagc gtgcagctcg ccgaccacta ccagcagaac 2760 acccccatcg gcgacggccc cgtgctgctg cccgacaacc actacctgag cacccagtcc 2820 gccctgagca aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc 2880 gccgccggga tcactctcgg catggacgag ctgtacaagt aacaccggtg gcgcgttaag 2940 tcgacaatca acctctggat tacaaaattt gtgaaagatt gactggtatt cttaactatg 3000 ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat gctattgctt 3060 cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct ctttatgagg 3120 agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc 3180 ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc gctttccccc 3240 tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc 3300 ggctgttggg cactgacaat tccgtggtgt tgtcggggaa atcatcgtcc tttccttggc 3360 tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac gtcccttcgg 3420 ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc 3480 gtcttcgcct tcgccctcag acgagtcgga tctccctttg ggccgcctcc ccgcgtcgac 3540 tttaagacca atgacttaca aggcagctgt agatcttagc cactttttaa aagaaaaggg 3600 gggactggaa gggctaattc actcccaacg aagacaagat ctgctttttg cttgtactgg 3660 gtctctctgg ttagaccaga tctgagcctg ggagctctct ggctaactag ggaacccact 3720 gcttaagcct caataaagct tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg 3780 tgactctggt aactagagat ccctcagacc cttttagtca gtgtggaaaa tctctagcag 3840 tacgtatagt agttcatgtc atcttattat tcagtattta taacttgcaa agaaatgaat 3900 atcagagagt gagaggaact tgtttattgc agcttataat ggttacaaat aaagcaatag 3960 catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa 4020 actcatcaat gtatcttatc atgtctggct ctagctatcc cgcccctaac tccgcccatc 4080 ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt 4140 atttatgcag aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc 4200 ttttttggag gcctagggac gtacccaatt cgccctatag tgagtcgtat tacgcgcgct 4260 cactggccgt cgttttacaa cgtcgtgact gggaaaaccc tggcgttacc caacttaatc 4320 gccttgcagc acatccccct ttcgccagct ggcgtaatag cgaagaggcc cgcaccgatc 4380 gcccttccca acagttgcgc agcctgaatg gcgaatggga cgcgccctgt agcggcgcat 4440 taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag 4500 cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc 4560 aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc 4620 ccaaaaaact tgattagggt gatggttcac gtagtgggcc atcgccctga tagacggttt 4680 ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa 4740 caacactcaa ccctatctcg gtctattctt ttgatttata agggattttg ccgatttcgg 4800 cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat 4860 taacgcttac aatttaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt 4920 atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct 4980 tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc 5040 cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa 5100 agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg 5160 taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt 5220 tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg 5280 catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac 5340 ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc 5400 ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa 5460 catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc 5520 aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt 5580 aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga 5640 taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa 5700 atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa 5760 gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa 5820 tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt 5880 ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt 5940 gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg 6000 agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt 6060 aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca 6120 agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac 6180 tgttcttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac 6240 atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct 6300 taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg 6360 gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca 6420 gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt 6480 aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta 6540 tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc 6600 gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc 6660 cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa 6720 ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag 6780 cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg 6840 ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag cgggcagtga 6900 gcgcaacgca attaatgtga gttagctcac tcattaggca ccccaggctt tacactttat 6960 gcttccggct cgtatgttgt gtggaattgt gagcggataa caatttcaca caggaaacag 7020 ctatgaccat gattacgcca agcgcgcaat taaccctcac taaagggaac aaaagctgga 7080 gctgcaagct taatgtagtc ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg 7140 agttagcaac atgccttaca aggagagaaa aagcaccgtg catgccgatt ggtggaagta 7200 aggtggtacg atcgtgcctt attaggaagg caacagacgg gtctgacatg gattggacga 7260 accactgaat tgccgcattg cagagatatt gtatttaagt gcctagctcg atacataaac 7320 gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca 7380 ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg 7440 tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc 7500 agtggcgccc gaacagggac ttgaaagcga aagggaaacc agaggagctc tctcgacgca 7560 ggactcggct tgctgaagcg cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc 7620 caaaaatttt gactagcgga ggctagaagg agagagatgg gtgcgagagc gtcagtatta 7680 agcgggggag aattagatcg cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa 7740 aatataaatt aaaacatata gtatgggcaa gcagggagct agaacgattc gcagttaatc 7800 ctggcctgtt agaaacatca gaaggctgta gacaaatact gggacagcta caaccatccc 7860 ttcagacagg atcagaagaa cttagatcat tatataatac agtagcaacc ctctattgtg 7920 tgcatcaaag gatagagata aaagacacca aggaagcttt agacaagata gaggaagagc 7980 aaaacaaaag taagaccacc gcacagcaag cggccgctga tcttcagacc tggaggagga 8040 gatatgaggg acaattggag aagtgaatta tataaatata aagtagtaaa aattgaacca 8100 ttaggagtag cacccaccaa ggcaaagaga agagtggtgc agagagaaaa aagagcagtg 8160 ggaataggag ctttgttcct tgggttcttg ggagcagcag gaagcactat gggcgcagcg 8220 tcaatgacgc tgacggtaca ggccagacaa ttattgtctg gtatagtgca gcagcagaac 8280 aatttgctga gggctattga ggcgcaacag catctgttgc aactcacagt ctggggcatc 8340 aagcagctcc aggcaagaat cctggctgtg gaaagatacc taaaggatca acagctcctg 8400 gggatttggg gttgctctgg aaaactcatt tgcaccactg ctgtgccttg gaatgctagt 8460 tggagtaata aatctctgga acagatttgg aatcacacga cctggatgga gtgggacaga 8520 gaaattaaca attacacaag cttaatacac tccttaattg aagaatcgca aaaccagcaa 8580 gaaaagaatg aacaagaatt attggaatta gataaatggg caagtttgtg gaattggttt 8640 aacataacaa attggctgtg gtatataaaa ttattcataa tgatagtagg aggcttggta 8700 ggtttaagaa tagtttttgc tgtactttct atagtgaata gagttaggca gggatattca 8760 ccattatcgt ttcagaccca cctcccaacc ccgaggggac ccttgcgcct tttccaaggc 8820 agccctgggt ttgcgcaggg acgcggctgc tctgggcgtg gttccgggaa acgcagcggc 8880 gccgaccctg ggtctcgcac attcttcacg tccgttcgca gcgtcacccg gatcttcgcc 8940 gctacccttg tgggcccccc ggcgacgctt cctgctccgc ccctaagtcg ggaaggttcc 9000 ttgcggttcg cggcgtgccg gacgtgacaa acggaagccg cacgtctcac tagtaccctc 9060 gcagacggac agcgccaggg agcaatggca gcgcgccgac cgcgatgggc tgtggccaat 9120 agcggctgct cagcagggcg cgccgagagc agcggccggg aaggggcggt gcgggaggcg 9180 gggtgtgggg cggtagtgtg ggccctgttc ctgcccgcgc ggtgttccgc attctgcaag 9240 cctccggagc gcacgtcggc agtcggctcc ctcgttgacc gaatcaccga cctctctccc 9300 cagggggtac ccagctgtct agagaattct agatcttgag acaaatggca gtattcatcc 9360 acaattttaa aagaaaaggg gggattgggg ggtacagtgc aggggaaaga atagtagaca 9420 taatagcaac agacatacaa actaaagaat tacaaaaaca aattacaaaa attcaaaatt 9480 ttcgggttta ttacagggac agcagagatc cactttggcg ccggctcgag gggg 9534 <210> 211 <211> 291 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 211 Met Ala Gln Leu Lys Lys Lys Leu Gln Ala Asn Lys Lys Glu Leu Ala 1 5 10 15 Gln Leu Lys Trp Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln Gly 20 25 30 Gly Gly Gly Ser Gly Ser Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu 35 40 45 Gly Lys Gln Asn Val Tyr Asp Ile Gly Val Gly Glu Pro His Asn Phe 50 55 60 Ala Leu Lys Asn Gly Phe Ile Ala Ser Asn Cys Ile Ser Arg Arg Ala 65 70 75 80 Gln Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val 85 90 95 Leu Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu 100 105 110 Ser Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln 115 120 125 Tyr Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val 130 135 140 Tyr His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala 145 150 155 160 Gln Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val 165 170 175 Arg His Leu Val His Ala Asp Phe Gly Cys Ile Ser Gly Asp Ser Leu 180 185 190 Ile Ser Leu Ala Ser Thr Gly Lys Arg Val Ser Ile Lys Asp Leu Leu 195 200 205 Asp Glu Lys Asp Phe Glu Ile Trp Ala Ile Asn Glu Gln Thr Met Lys 210 215 220 Leu Glu Ser Ala Lys Val Ser Arg Val Phe Cys Thr Gly Lys Lys Leu 225 230 235 240 Val Tyr Ile Leu Lys Thr Arg Leu Gly Arg Thr Ile Lys Ala Thr Ala 245 250 255 Asn His Arg Phe Leu Thr Ile Asp Gly Trp Lys Arg Leu Asp Glu Leu 260 265 270 Ser Leu Lys Glu His Ile Ala Leu Pro Arg Lys Leu Glu Ser Ser Ser 275 280 285 Leu Gln Leu 290 <210> 212 <211> 9345 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 212 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatgagtcc cgaaatcgaa 660 aagctctctc agagcgatat atattgggac tccatcgtaa gcataacaga gacgggggtc 720 gaggaggtgt tcgatctgac agttcctggg cctcataatt tcgtagcgaa cgacatcatt 780 gtacataact ccaacaatgt cctgacggac aatggccgca taacagcggt cattgactgg 840 agcgaggcga tgttcgggga ttcccaatac gaggtcgcca acatcttctt ctggaggccg 900 tggttggctt gcctttcata cgagaccgag atcctgactg tcgagtacgg attgcttcct 960 atcggcaaaa tcgtggagaa gaggattgaa tgtaccgtct attcagtcga taataatggg 1020 aacatctaca cacagcccgt ggctcaatgg cacgacagag gagagcagga agtttttgaa 1080 tactgtctcg aggacggatc cctcatccgc gctactaaag atcataagtt tatgaccgtg 1140 gacggccaga tgctgccaat tgacgaaatt tttgaacgag agctggatct gatgagagtc 1200 gacaaccttc caaacggtgg aggggggtca ggctctgcgc agctggaaaa ggagcttcaa 1260 gccctcgaaa aaaagttggc ccagctcgag tgggagaacc aggctctgga gaaagaactg 1320 gcccagtgat taattaagaa ttcgacccag ctttcttgta caaagtggtt ggtaagccta 1380 tccctaaccc tctcctcggt ctcgattcta cgtagtaatg agctagcagt ctcgaggtta 1440 acgaattccg ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg 1500 cgcttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga 1560 aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa 1620 tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa 1680 caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcccct 1740 gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg 1800 ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg 1860 ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtgca 1920 catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg 1980 acgtggtttt cctttgaaaa acacgataat accatggtga gcaagggcga ggagctgttc 2040 accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc 2100 gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc 2160 accaccggca agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg 2220 cagtgcttca gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg 2280 cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc 2340 cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc 2400 gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac 2460 aacgtctata tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc 2520 cacaacatcg aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc 2580 ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc 2640 aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg 2700 atcactctcg gcatggacga gctgtacaag taacaccggt ggcgcgttaa gtcgacaatc 2760 aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat gttgctcctt 2820 ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct tcccgtatgg 2880 ctttcatttt ctcctccttg tataaatcct ggttgctgtc tctttatgag gagttgtggc 2940 ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc cccactggtt 3000 ggggcattgc caccacctgt cagctccttt ccgggacttt cgctttcccc ctccctattg 3060 ccacggcgga actcatcgcc gcctgccttg cccgctgctg gacaggggct cggctgttgg 3120 gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc ctttccttgg ctgctcgcct 3180 gtgttgccac ctggattctg cgcgggacgt ccttctgcta cgtcccttcg gccctcaatc 3240 cagcggacct tccttcccgc ggcctgctgc cggctctgcg gcctcttccg cgtcttcgcc 3300 ttcgccctca gacgagtcgg atctcccttt gggccgcctc cccgcgtcga ctttaagacc 3360 aatgacttac aaggcagctg tagatcttag ccacttttta aaagaaaagg ggggactgga 3420 agggctaatt cactcccaac gaagacaaga tctgcttttt gcttgtactg ggtctctctg 3480 gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc 3540 tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg 3600 taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtacgtatag 3660 tagttcatgt catcttatta ttcagtattt ataacttgca aagaaatgaa tatcagagag 3720 tgagaggaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa 3780 tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa 3840 tgtatcttat catgtctggc tctagctatc ccgcccctaa ctccgcccat cccgccccta 3900 actccgccca gttccgccca ttctccgccc catggctgac taattttttt tatttatgca 3960 gaggccgagg ccgcctcggc ctctgagcta ttccagaagt agtgaggagg cttttttgga 4020 ggcctaggga cgtacccaat tcgccctata gtgagtcgta ttacgcgcgc tcactggccg 4080 tcgttttaca acgtcgtgac tgggaaaacc ctggcgttac ccaacttaat cgccttgcag 4140 cacatccccc tttcgccagc tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc 4200 aacagttgcg cagcctgaat ggcgaatggg acgcgccctg tagcggcgca ttaagcgcgg 4260 cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc 4320 ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa 4380 atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac 4440 ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt 4500 tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca 4560 accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt 4620 taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgctta 4680 caatttaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta 4740 aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata 4800 ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc 4860 ggcattttgc cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga 4920 agatcagttg ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct 4980 tgagagtttt cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg 5040 tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta 5100 ttctcagaat gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat 5160 gacagtaaga gaattatgca gtgctgccat aaccatgagt gataacactg cggccaactt 5220 acttctgaca acgatcggag gaccgaagga gctaaccgct tttttgcaca acatggggga 5280 tcatgtaact cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga 5340 gcgtgacacc acgatgcctg tagcaatggc aacaacgttg cgcaaactat taactggcga 5400 actacttact ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc 5460 aggaccactt ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc 5520 cggtgagcgt gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg 5580 tatcgtagtt atctacacga cggggagtca ggcaactatg gatgaacgaa atagacagat 5640 cgctgagata ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata 5700 tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct 5760 ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga 5820 ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg 5880 cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc 5940 aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgttcttct 6000 agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc 6060 tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt 6120 ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg 6180 cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct 6240 atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag 6300 ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag 6360 tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg 6420 gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg 6480 gccttttgct cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac 6540 cgcctttgag tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt 6600 gagcgaggaa gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat 6660 tcattaatgc agctggcacg acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc 6720 aattaatgtg agttagctca ctcattaggc accccaggct ttacacttta tgcttccggc 6780 tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca gctatgacca 6840 tgattacgcc aagcgcgcaa ttaaccctca ctaaagggaa caaaagctgg agctgcaagc 6900 ttaatgtagt cttatgcaat actcttgtag tcttgcaaca tggtaacgat gagttagcaa 6960 catgccttac aaggagagaa aaagcaccgt gcatgccgat tggtggaagt aaggtggtac 7020 gatcgtgcct tattaggaag gcaacagacg ggtctgacat ggattggacg aaccactgaa 7080 ttgccgcatt gcagagatat tgtatttaag tgcctagctc gatacataaa cgggtctctc 7140 tggttagacc agatctgagc ctgggagctc tctggctaac tagggaaccc actgcttaag 7200 cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg cccgtctgtt gtgtgactct 7260 ggtaactaga gatccctcag acccttttag tcagtgtgga aaatctctag cagtggcgcc 7320 cgaacaggga cttgaaagcg aaagggaaac cagaggagct ctctcgacgc aggactcggc 7380 ttgctgaagc gcgcacggca agaggcgagg ggcggcgact ggtgagtacg ccaaaaattt 7440 tgactagcgg aggctagaag gagagagatg ggtgcgagag cgtcagtatt aagcggggga 7500 gaattagatc gcgatgggaa aaaattcggt taaggccagg gggaaagaaa aaatataaat 7560 taaaacatat agtatgggca agcagggagc tagaacgatt cgcagttaat cctggcctgt 7620 tagaaacatc agaaggctgt agacaaatac tgggacagct acaaccatcc cttcagacag 7680 gatcagaaga acttagatca ttatataata cagtagcaac cctctattgt gtgcatcaaa 7740 ggatagagat aaaagacacc aaggaagctt tagacaagat agaggaagag caaaacaaaa 7800 gtaagaccac cgcacagcaa gcggccgctg atcttcagac ctggaggagg agatatgagg 7860 gacaattgga gaagtgaatt atataaatat aaagtagtaa aaattgaacc attaggagta 7920 gcacccacca aggcaaagag aagagtggtg cagagagaaa aaagagcagt gggaatagga 7980 gctttgttcc ttgggttctt gggagcagca ggaagcacta tgggcgcagc gtcaatgacg 8040 ctgacggtac aggccagaca attattgtct ggtatagtgc agcagcagaa caatttgctg 8100 agggctattg aggcgcaaca gcatctgttg caactcacag tctggggcat caagcagctc 8160 caggcaagaa tcctggctgt ggaaagatac ctaaaggatc aacagctcct ggggatttgg 8220 ggttgctctg gaaaactcat ttgcaccact gctgtgcctt ggaatgctag ttggagtaat 8280 aaatctctgg aacagatttg gaatcacacg acctggatgg agtgggacag agaaattaac 8340 aattacacaa gcttaataca ctccttaatt gaagaatcgc aaaaccagca agaaaagaat 8400 gaacaagaat tattggaatt agataaatgg gcaagtttgt ggaattggtt taacataaca 8460 aattggctgt ggtatataaa attattcata atgatagtag gaggcttggt aggtttaaga 8520 atagtttttg ctgtactttc tatagtgaat agagttaggc agggatattc accattatcg 8580 tttcagaccc acctcccaac cccgagggga cccttgcgcc ttttccaagg cagccctggg 8640 tttgcgcagg gacgcggctg ctctgggcgt ggttccggga aacgcagcgg cgccgaccct 8700 gggtctcgca cattcttcac gtccgttcgc agcgtcaccc ggatcttcgc cgctaccctt 8760 gtgggccccc cggcgacgct tcctgctccg cccctaagtc gggaaggttc cttgcggttc 8820 gcggcgtgcc ggacgtgaca aacggaagcc gcacgtctca ctagtaccct cgcagacgga 8880 cagcgccagg gagcaatggc agcgcgccga ccgcgatggg ctgtggccaa tagcggctgc 8940 tcagcagggc gcgccgagag cagcggccgg gaaggggcgg tgcgggaggc ggggtgtggg 9000 gcggtagtgt gggccctgtt cctgcccgcg cggtgttccg cattctgcaa gcctccggag 9060 cgcacgtcgg cagtcggctc cctcgttgac cgaatcaccg acctctctcc ccagggggta 9120 cccagctgtc tagagaattc tagatcttga gacaaatggc agtattcatc cacaatttta 9180 aaagaaaagg ggggattggg gggtacagtg caggggaaag aatagtagac ataatagcaa 9240 cagacataca aactaaagaa ttacaaaaac aaattacaaa aattcaaaat tttcgggttt 9300 attacaggga cagcagagat ccactttggc gccggctcga ggggg 9345 <210> 213 <211> 228 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 213 Met Ser Pro Glu Ile Glu Lys Leu Ser Gln Ser Asp Ile Tyr Trp Asp 1 5 10 15 Ser Ile Val Ser Ile Thr Glu Thr Gly Val Glu Glu Val Phe Asp Leu 20 25 30 Thr Val Pro Gly Pro His Asn Phe Val Ala Asn Asp Ile Ile Val His 35 40 45 Asn Ser Asn Asn Val Leu Thr Asp Asn Gly Arg Ile Thr Ala Val Ile 50 55 60 Asp Trp Ser Glu Ala Met Phe Gly Asp Ser Gln Tyr Glu Val Ala Asn 65 70 75 80 Ile Phe Phe Trp Arg Pro Trp Leu Ala Cys Leu Ser Tyr Glu Thr Glu 85 90 95 Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu 100 105 110 Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile 115 120 125 Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val 130 135 140 Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp 145 150 155 160 His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile 165 170 175 Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn Gly 180 185 190 Gly Gly Gly Ser Gly Ser Ala Gln Leu Glu Lys Glu Leu Gln Ala Leu 195 200 205 Glu Lys Lys Leu Ala Gln Leu Glu Trp Glu Asn Gln Ala Leu Glu Lys 210 215 220 Glu Leu Ala Gln 225 <210> 214 <211> 9177 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 214 cccggggtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 60 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 120 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 180 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 240 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 300 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 360 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 420 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 480 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 540 gtgtacggtg ggaggtctat ataagcagag ctctctggct aactgtcggg atcaacaagt 600 ttgtacaaaa aagcaggctc cgaattcacc ggtgccgcca ccatggctca actgaagaag 660 aaactccagg ccaataagaa agaactggca cagctgaagt ggaagctgca ggcactgaaa 720 aagaagctgg cacagggcgg aggaggctca ggcagtatga ttaagatcgc tacgcggaag 780 tacctgggga aacagaacgt ctacgacata ggtgtgggcg agccccacaa ctttgctctg 840 aaaaatggat ttatcgccag caactgtatg gagcagcaga cgcgctactt cgagcggagg 900 catccggagc ttgcaggatc gccgcggctc cgggcgtata tgctccgcat tggtcttgac 960 caactctatc agagcttggt tgacggcaat ttcgatgatg cagcttgggc gcagggtcga 1020 tgcgacgcaa tcgtccgatc cggagccggg actgtcgggc gtacacaaat cgcccgcaga 1080 agcgcggccg tctggaccga tggctgtgta gaagtactcg ccgatagtgg aaaccgacgc 1140 cccagcactc gtccgagggc aaaggaatag ttaattaaga attcgaccca gctttcttgt 1200 acaaagtggt tggtaagcct atccctaacc ctctcctcgg tctcgattct acgtagtaat 1260 gagctagcag tctcgaggtt aacgaattcc gccccccccc taacgttact ggccgaagcc 1320 gcttggaata aggccggtgt gcgcttgtct atatgttatt ttccaccata ttgccgtctt 1380 ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt gacgagcatt cctaggggtc 1440 tttcccctct cgccaaagga atgcaaggtc tgttgaatgt cgtgaaggaa gcagttcctc 1500 tggaagcttc ttgaagacaa acaacgtctg tagcgaccct ttgcaggcag cggaaccccc 1560 cacctggcga caggtgcccc tgcggccaaa agccacgtgt ataagataca cctgcaaagg 1620 cggcacaacc ccagtgccac gttgtgagtt ggatagttgt ggaaagagtc aaatggctct 1680 cctcaagcgt attcaacaag gggctgaagg atgcccagaa ggtaccccat tgtatgggat 1740 ctgatctggg gcctcggtgc acatgcttta catgtgttta gtcgaggtta aaaaaacgtc 1800 taggcccccc gaaccacggg gacgtggttt tcctttgaaa aacacgataa taccatggtg 1860 agcaagggcg aggaggataa catggccatc atcaaggagt tcatgcgctt caaggtgcac 1920 atggagggct ccgtgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc 1980 tacgagggca cccagaccgc caagctgaag gtgaccaagg gtggccccct gcccttcgcc 2040 tgggacatcc tgtcccctca gttcatgtac ggctccaagg cctacgtgaa gcaccccgcc 2100 gacatccccg actacttgaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg 2160 aacttcgagg acggcggcgt ggtgaccgtg acccaggact cctccctgca ggacggcgag 2220 ttcatctaca aggtgaagct gcgcggcacc aacttcccct ccgacggccc cgtaatgcag 2280 aagaagacca tgggctggga ggcctcctcc gagcggatgt accccgagga cggcgccctg 2340 aagggcgaga tcaagcagag gctgaagctg aaggacggcg gccactacga cgctgaggtc 2400 aagaccacct acaaggccaa gaagcccgtg cagctgcccg gcgcctacaa cgtcaacatc 2460 aagttggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgaacgcgcc 2520 gagggccgcc actccaccgg cggcatggac gagctgtaca agtaacaccg gtggcgcgtt 2580 aagtcgacaa tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact 2640 atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg 2700 cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg 2760 aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa 2820 cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc 2880 ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg 2940 ctcggctgtt gggcactgac aattccgtgg tgttgtcggg gaaatcatcg tcctttcctt 3000 ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt 3060 cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc 3120 cgcgtcttcg ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgcgtc 3180 gactttaaga ccaatgactt acaaggcagc tgtagatctt agccactttt taaaagaaaa 3240 ggggggactg gaagggctaa ttcactccca acgaagacaa gatctgcttt ttgcttgtac 3300 tgggtctctc tggttagacc agatctgagc ctgggagctc tctggctaac tagggaaccc 3360 actgcttaag cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg cccgtctgtt 3420 gtgtgactct ggtaactaga gatccctcag acccttttag tcagtgtgga aaatctctag 3480 cagtacgtat agtagttcat gtcatcttat tattcagtat ttataacttg caaagaaatg 3540 aatatcagag agtgagagga acttgtttat tgcagcttat aatggttaca aataaagcaa 3600 tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc 3660 caaactcatc aatgtatctt atcatgtctg gctctagcta tcccgcccct aactccgccc 3720 atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt 3780 tttatttatg cagaggccga ggccgcctcg gcctctgagc tattccagaa gtagtgagga 3840 ggcttttttg gaggcctagg gacgtaccca attcgcccta tagtgagtcg tattacgcgc 3900 gctcactggc cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta 3960 atcgccttgc agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg 4020 atcgcccttc ccaacagttg cgcagcctga atggcgaatg ggacgcgccc tgtagcggcg 4080 cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc 4140 tagcgcccgc tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc 4200 gtcaagctct aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg 4260 accccaaaaa acttgattag ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg 4320 tttttcgccc tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg 4380 gaacaacact caaccctatc tcggtctatt cttttgattt ataagggatt ttgccgattt 4440 cggcctattg gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa 4500 tattaacgct tacaatttag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg 4560 tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat 4620 gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat 4680 tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt 4740 aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag 4800 cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa 4860 agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg 4920 ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct 4980 tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac 5040 tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca 5100 caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat 5160 accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact 5220 attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc 5280 ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga 5340 taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg 5400 taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg 5460 aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca 5520 agtttactca tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta 5580 ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca 5640 ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg 5700 cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga 5760 tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa 5820 tactgttctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc 5880 tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg 5940 tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac 6000 ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct 6060 acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc 6120 ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg 6180 gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg 6240 ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct 6300 ggccttttgc tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga 6360 taaccgtatt accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg 6420 cagcgagtca gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc 6480 gcgttggccg attcattaat gcagctggca cgacaggttt cccgactgga aagcgggcag 6540 tgagcgcaac gcaattaatg tgagttagct cactcattag gcaccccagg ctttacactt 6600 tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc acacaggaaa 6660 cagctatgac catgattacg ccaagcgcgc aattaaccct cactaaaggg aacaaaagct 6720 ggagctgcaa gcttaatgta gtcttatgca atactcttgt agtcttgcaa catggtaacg 6780 atgagttagc aacatgcctt acaaggagag aaaaagcacc gtgcatgccg attggtggaa 6840 gtaaggtggt acgatcgtgc cttattagga aggcaacaga cgggtctgac atggattgga 6900 cgaaccactg aattgccgca ttgcagagat attgtattta agtgcctagc tcgatacata 6960 aacgggtctc tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac 7020 ccactgctta agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg 7080 ttgtgtgact ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct 7140 agcagtggcg cccgaacagg gacttgaaag cgaaagggaa accagaggag ctctctcgac 7200 gcaggactcg gcttgctgaa gcgcgcacgg caagaggcga ggggcggcga ctggtgagta 7260 cgccaaaaat tttgactagc ggaggctaga aggagagaga tgggtgcgag agcgtcagta 7320 ttaagcgggg gagaattaga tcgcgatggg aaaaaattcg gttaaggcca gggggaaaga 7380 aaaaatataa attaaaacat atagtatggg caagcaggga gctagaacga ttcgcagtta 7440 atcctggcct gttagaaaca tcagaaggct gtagacaaat actgggacag ctacaaccat 7500 cccttcagac aggatcagaa gaacttagat cattatataa tacagtagca accctctatt 7560 gtgtgcatca aaggatagag ataaaagaca ccaaggaagc tttagacaag atagaggaag 7620 agcaaaacaa aagtaagacc accgcacagc aagcggccgc tgatcttcag acctggagga 7680 ggagatatga gggacaattg gagaagtgaa ttatataaat ataaagtagt aaaaattgaa 7740 ccattaggag tagcacccac caaggcaaag agaagagtgg tgcagagaga aaaaagagca 7800 gtgggaatag gagctttgtt ccttgggttc ttgggagcag caggaagcac tatgggcgca 7860 gcgtcaatga cgctgacggt acaggccaga caattattgt ctggtatagt gcagcagcag 7920 aacaatttgc tgagggctat tgaggcgcaa cagcatctgt tgcaactcac agtctggggc 7980 atcaagcagc tccaggcaag aatcctggct gtggaaagat acctaaagga tcaacagctc 8040 ctggggattt ggggttgctc tggaaaactc atttgcacca ctgctgtgcc ttggaatgct 8100 agttggagta ataaatctct ggaacagatt tggaatcaca cgacctggat ggagtgggac 8160 agagaaatta acaattacac aagcttaata cactccttaa ttgaagaatc gcaaaaccag 8220 caagaaaaga atgaacaaga attattggaa ttagataaat gggcaagttt gtggaattgg 8280 tttaacataa caaattggct gtggtatata aaattattca taatgatagt aggaggcttg 8340 gtaggtttaa gaatagtttt tgctgtactt tctatagtga atagagttag gcagggatat 8400 tcaccattat cgtttcagac ccacctccca accccgaggg gacccttgcg ccttttccaa 8460 ggcagccctg ggtttgcgca gggacgcggc tgctctgggc gtggttccgg gaaacgcagc 8520 ggcgccgacc ctgggtctcg cacattcttc acgtccgttc gcagcgtcac ccggatcttc 8580 gccgctaccc ttgtgggccc cccggcgacg cttcctgctc cgcccctaag tcgggaaggt 8640 tccttgcggt tcgcggcgtg ccggacgtga caaacggaag ccgcacgtct cactagtacc 8700 ctcgcagacg gacagcgcca gggagcaatg gcagcgcgcc gaccgcgatg ggctgtggcc 8760 aatagcggct gctcagcagg gcgcgccgag agcagcggcc gggaaggggc ggtgcgggag 8820 gcggggtgtg gggcggtagt gtgggccctg ttcctgcccg cgcggtgttc cgcattctgc 8880 aagcctccgg agcgcacgtc ggcagtcggc tccctcgttg accgaatcac cgacctctct 8940 ccccaggggg tacccagctg tctagagaat tctagatctt gagacaaatg gcagtattca 9000 tccacaattt taaaagaaaa ggggggattg gggggtacag tgcaggggaa agaatagtag 9060 acataatagc aacagacata caaactaaag aattacaaaa acaaattaca aaaattcaaa 9120 attttcgggt ttattacagg gacagcagag atccactttg gcgccggctc gaggggg 9177 <210> 215 <211> 175 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Polypeptide <400> 215 Met Ala Gln Leu Lys Lys Lys Leu Gln Ala Asn Lys Lys Glu Leu Ala 1 5 10 15 Gln Leu Lys Trp Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln Gly 20 25 30 Gly Gly Gly Ser Gly Ser Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu 35 40 45 Gly Lys Gln Asn Val Tyr Asp Ile Gly Val Gly Glu Pro His Asn Phe 50 55 60 Ala Leu Lys Asn Gly Phe Ile Ala Ser Asn Cys Met Glu Gln Gln Thr 65 70 75 80 Arg Tyr Phe Glu Arg Arg His Pro Glu Leu Ala Gly Ser Pro Arg Leu 85 90 95 Arg Ala Tyr Met Leu Arg Ile Gly Leu Asp Gln Leu Tyr Gln Ser Leu 100 105 110 Val Asp Gly Asn Phe Asp Asp Ala Ala Trp Ala Gln Gly Arg Cys Asp 115 120 125 Ala Ile Val Arg Ser Gly Ala Gly Thr Val Gly Arg Thr Gln Ile Ala 130 135 140 Arg Arg Ser Ala Ala Val Trp Thr Asp Gly Cys Val Glu Val Leu Ala 145 150 155 160 Asp Ser Gly Asn Arg Arg Pro Ser Thr Arg Pro Arg Ala Lys Glu 165 170 175 <210> 216 <211> 926 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 216 cgcagcaccg gtgccgccac catgattaag atcgctacgc ggaagtacct ggggaaacag 60 aacgtctacg acataggtgt ggagcgcgat cacaactttg ctctgaaaaa tggatttatc 120 gccagcaact gcttcaatgg cggaggcgga tctcaccacc atcatcacca tggatcaatc 180 gatgatccca agaagaaacg caaggtggat cccaagaaga agaggaaagt agaccccaag 240 aaaaagagga aggtgggatc aactgggtct cgcggaggtg gggggtcagg cggaggtggc 300 tcaggaggcg gaggctcagg gcgcgccgga tccggacgcg ccgacgcgct ggacgatttc 360 gatctcgaca tgctgggttc tgatgccctc gatgactttg acctggatat gttgggaagc 420 gacgcattgg atgactttga tctggacatg ctcggctccg atgctctgga cgatttcgat 480 ctcgatatgt tatatggcgg ccgcggaggc ggcggttccg gaggtggtgg aagtgggggt 540 ggagggtctc cgaagaaaaa gcgcaaggtc gggccggccg gtggaggagg tagcgctgag 600 tactgccttt catacgagac cgagatcctg actgtcgagt acggattgct tcctatcggc 660 aaaatcgtgg agaagaggat tgaatgtacc gtctattcag tcgataataa tgggaacatc 720 tacacacagc ccgtggctca atggcacgac agaggagagc aggaagtttt tgaatactgt 780 ctcgaggacg gatccctcat ccgcgctact aaagatcata agtttatgac cgtggacggc 840 cagatgctgc caattgacga aatttttgaa cgagagctgg atctgatgag agtcgacaac 900 cttccaaact gattaattaa gcgtcg 926 <210> 217 <211> 977 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 217 cgcagcaccg gtgccgccac catgagcact ggaaagcgag ttagcatcaa ggacttgctg 60 gacgaaaagg atttcgaaat ttgggcaatc aatgagcaga ccatgaaact ggagtctgca 120 aaggtgtccc gggtgttttg cacgggtaag aagcttgttt atatccttaa aactagactg 180 ggccggacga tcaaagccac cgcgaaccac agattcttga caatcgacgg gtggaaacgg 240 ctggacgaac tgagcttgaa ggagcacatc gcccttcctc ggaagctcga gtcatcttcc 300 ctgcagctga gtcccgaaat cgaaaagctc tctcagagcg atatatattg ggactccatc 360 gtaagcataa cagagacggg ggtcgaggag gtgttcgatc tgacagttcc tgggcctcat 420 aatttcgtag cgaacgacat cattgtacat aactccattg aaggcggagg cggatctcac 480 caccatcatc accatggatc aatcgatgat cccaagaaga aacgcaaggt ggatcccaag 540 aagaagagga aagtagaccc caagaaaaag aggaaggtgg gatcaactgg gtctcgcgga 600 ggtggggggt caggcggagg tggctcagga ggcggaggct cagggcgcgc cggatccgga 660 cgcgccgacg cgctggacga tttcgatctc gacatgctgg gttctgatgc cctcgatgac 720 tttgacctgg atatgttggg aagcgacgca ttggatgact ttgatctgga catgctcggc 780 tccgatgctc tggacgattt cgatctcgat atgttatatg gcggccgcgg aggcggcggt 840 tccggaggtg gtggaagtgg gggtggaggg tctccgaaga aaaagcgcaa ggtcgggccg 900 gccggtggag gaggtagcga atccggatgt atcagtggcg actccctgat ctcactcgca 960 tgattaatta agcgtag 977 <210> 218 <211> 4304 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Polynucleotide <400> 218 ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga 60 taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga 120 gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca 180 cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaata cgcgtaccgc 240 tagccaggaa gagtttgtag aaacgcaaaa aggccatccg tcaggatggc cttctgctta 300 gtttgatgcc tggcagttta tggcgggcgt cctgcccgcc accctccggg ccgttgcttc 360 acaacgatca aatccgctcc cggcggattt gtcctactca ggagagcgtt caccgacaaa 420 caacagataa aacgaaaggc ccagtcttcc gactgagcct ttcgttttat ttgatgcctg 480 gcagttccct actctcgcgt taacgctagc atggatgttt tcccagtcac gacgttgtaa 540 aacgacggcc agtcttaagc tcgggcccca aataatgatt ttattttgac tgatagtgac 600 ctgttcgttg caacaaattg atgagcaatg cttttttata atgccaactt tgtacaaaaa 660 agcaggctcc gaattcaccg gtgccgccac catggggccg gccgcggccg cattaggcac 720 cccaggcttt acactttatg cttccggctc gtataatgtg tggattttga gttaggatcc 780 gtcgagattt tcaggagcta aggaagctaa aatggagaaa aaaatcactg gatataccac 840 cgttgatata tcccaatggc atcgtaaaga acattttgag gcatttcagt cagttgctca 900 atgtacctat aaccagaccg ttcagctgga tattacggcc tttttaaaga ccgtaaagaa 960 aaataagcac aagttttatc cggcctttat tcacattctt gcccgcctga tgaatgctca 1020 tccggaattc cgtatggcaa tgaaagacgg tgagctggtg atatgggata gtgttcaccc 1080 ttgttacacc gttttccatg agcaaactga aaccttttca tcgctctgga gtgaatacca 1140 cgacgatttc cggcagtttc tacacatata ttcgcaagat gtggcgtgtt acggtgaaaa 1200 cctggcctat ttccctaaag ggtttattga gaatatgttt ttcgtctcag ccaatccctg 1260 ggtgagtttc accagttttg atttaaacgt ggccaatatg gacaacttct tcgcccccgt 1320 tttcaccatg ggcaaatatt atacgcaagg cgacaaggtg ctgatgccgc tggcgattca 1380 ggttcatcat gccgtttgtg atggcttcca tgtcggcaga atgcttaatg aattacaaca 1440 gtactgcgat gagtggcagg gcggggcgta aagatctgga tccggcttac taaaagccag 1500 ataacagtat gcgtatttgc gcgctgattt ttgcggtata agaatatata ctgatatgta 1560 tacccgaagt atgtcaaaaa gaggtatgct atgaagcagc gtattacagt gacagttgac 1620 agcgacagct atcagttgct caaggcatat atgatgtcaa tatctccggt ctggtaagca 1680 caaccatgca gaatgaagcc cgtcgtctgc gtgccgaacg ctggaaagcg gaaaatcagg 1740 aagggatggc tgaggtcgcc cggtttattg aaatgaacgg ctcttttgct gacgagaaca 1800 ggggctggtg aaatgcagtt taaggtttac acctataaaa gagagagccg ttatcgtctg 1860 tttgtggatg tacagagtga tattattgac acgcccgggc gacggatggt gatccccctg 1920 gccagtgcac gtctgctgtc agataaagtc tcccgtgaac tttacccggt ggtgcatatc 1980 ggggatgaaa gctggcgcat gatgaccacc gatatggcca gtgtgccggt ctccgttatc 2040 ggggaagaag tggctgatct cagccaccgc gaaaatgaca tcaaaaacgc cattaacctg 2100 atgttctggg gaatataaat gtcaggctcc cttatacaca gccagtctgc aggtcgacaa 2160 cgtttgatta attaagaatt cgacccagct ttcttgtaca aagttggcat tataaaaaat 2220 aattgctcat caatttgttg caacgaacag gtcactatca gtcaaaataa aatcattatt 2280 tgccatccag ctgatatccc ctatagtgag tcgtattaca tggtcatagc tgtttcctgg 2340 cagctctggc ccgtgtctca aaatctctga tgttacattg cacaagataa aaatatatca 2400 tcatgcctcc tctagaccag ccaggacaga aatgcctcga cttcgctgct gcccaaggtt 2460 gccgggtgac gcacaccgtg gaaacggatg aaggcacgaa cccagtggac ataagcctgt 2520 tcggttcgta agctgtaatg caagtagcgt atgcgctcac gcaactggtc cagaaccttg 2580 accgaacgca gcggtggtaa cggcgcagtg gcggttttca tggcttgtta tgactgtttt 2640 tttggggtac agtctatgcc tcgggcatcc aagcagcaag cgcgttacgc cgtgggtcga 2700 tgtttgatgt tatggagcag caacgatgtt acgcagcagg gcagtcgccc taaaacaaag 2760 ttaaacatca tgagggaagc ggtgatcgcc gaagtatcga ctcaactatc agaggtagtt 2820 ggcgtcatcg agcgccatct cgaaccgacg ttgctggccg tacatttgta cggctccgca 2880 gtggatggcg gcctgaagcc acacagtgat attgatttgc tggttacggt gaccgtaagg 2940 cttgatgaaa caacgcggcg agctttgatc aacgaccttt tggaaacttc ggcttcccct 3000 ggagagagcg agattctccg cgctgtagaa gtcaccattg ttgtgcacga cgacatcatt 3060 ccgtggcgtt atccagctaa gcgcgaactg caatttggag aatggcagcg caatgacatt 3120 cttgcaggta tcttcgagcc agccacgatc gacattgatc tggctatctt gctgacaaaa 3180 gcaagagaac atagcgttgc cttggtaggt ccagcggcgg aggaactctt tgatccggtt 3240 cctgaacagg atctatttga ggcgctaaat gaaaccttaa cgctatggaa ctcgccgccc 3300 gactgggctg gcgatgagcg aaatgtagtg cttacgttgt cccgcatttg gtacagcgca 3360 gtaaccggca aaatcgcgcc gaaggatgtc gctgccgact gggcaatgga gcgcctgccg 3420 gcccagtatc agcccgtcat acttgaagct agacaggctt atcttggaca agaagaagat 3480 cgcttggcct cgcgcgcaga tcagttggaa gaatttgtcc actacgtgaa aggcgagatc 3540 accaaggtag tcggcaaata accctcgagc cacccatgac caaaatccct taacgtgagt 3600 tacgcgtcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat 3660 cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg 3720 gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga 3780 gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac 3840 tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt 3900 ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag 3960 cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc 4020 gaactgagat acctacagcg tgagcattga gaaagcgcca cgcttcccga agggagaaag 4080 gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca 4140 gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt 4200 cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc 4260 tttttacggt tcctggcctt ttgctggcct tttgctcaca tgtt 4304

Claims (21)

  1. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터; 및
    (b) (i) 선택가능한 마커 단백질의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터
    를 진핵생물 세포로 전달하는 것을 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 N-말단 단편 및 C-말단 단편의 연결을 촉매하여 전장 선택가능한 마커 단백질을 생성하는 것인 방법.
  2. 제1항에 있어서, 트랜스제닉 진핵생물 세포를 생성하기 위해 진핵생물 세포로의 제1 및 제2 벡터의 도입을 허용하는 조건 하에 진핵생물 세포를 유지하는 것을 추가로 포함하는 방법.
  3. 제2항에 있어서, 전장 선택가능한 마커 단백질을 포함하는 트랜스제닉 진핵생물 세포를 선택하는 것을 추가로 포함하는 방법.
  4. 제1항 내지 제3항 중 어느 한 항에 있어서, 진핵생물 세포가 포유동물 세포인 방법.
  5. 제1항 내지 제4항 중 어느 한 항에 있어서, 선택가능한 마커 단백질이 항생제 내성 단백질인 방법.
  6. 제5항에 있어서, 항생제 내성 단백질이 히그로마이신, G418, 퓨로마이신, 플레오마이신 D1 또는 블라스티시딘에 대한 내성을 부여하는 것인 방법.
  7. 제5항 또는 제6항에 있어서, 항생제 내성 단백질이 hygB 유전자, bsr 유전자, pac 유전자 또는 neo 유전자에 의해 코딩된 것인 방법.
  8. 제1항 내지 제4항 중 어느 한 항에 있어서, 선택가능한 마커 단백질이 형광 단백질인 방법.
  9. 제8항에 있어서, 형광 단백질이 TagCFP, mTagCFP2, Czurite, ECFP2, mKalama1, Sirius, Sapphire, T-Sapphire, ECFP, Cerulean, SCFP3C, mTurquoise, mTurquoise2, 모노머 Midoriishi-Cyan, TagCFP, mTFP1, EGFP, Emerald, Superfolder GFP, 모노머 Czami Green, TagGFP2, mUKG, mWasabi, Clover, mNeonGreen, EYFP, Citrine, Venus, SYFP2, TagYFP, 모노머 Kusabira-Orange, mKOκ, mKO2, mOrange, mOrange2, mRaspberry, mCherry, mStrawberry, mScarlet, mTangerine, tdTomato, TagRFP, TagRFP-T, mCpple, mRuby, mRuby2, mPlum, HcRed-Tandem, mKate2, mNeptune, NirFP, TagRFP657, IFP1.4 및 iRFP로부터 선택된 것인 방법.
  10. 제1항 내지 제9항 중 어느 한 항에 있어서, 인테인이 분할 인테인인 방법.
  11. 제10항에 있어서, 분할 인테인이 자연 분할이며, 임의로 여기서 자연 분할 인테인이 DnaE 인테인으로부터 선택되고, 임의로 DnaE 인테인이 시네코시스티스(Synechocystis) sp. DnaE (SspDnaE) 인테인 및 노스톡 푼크티포르메(Nostoc punctiforme) (NpuDnaE) 인테인으로부터 선택된 것인 방법.
  12. 제10항에 있어서, 분할 인테인이 조작된 분할 인테인이며, 임의로 여기서 조작된 분할 인테인이 DnaB 인테인 또는 GyrB 인테인으로부터 조작되고, 임의로 조작된 분할 인테인이 SspDnaB S1 인테인 또는 SspGyrB S11 인테인인 방법.
  13. 제1항 내지 제12항 중 어느 한 항에 있어서, 제1 및/또는 제2 분자가 단백질 또는 비-코딩 리보핵산 (RNA)이고, 임의로 여기서 비-코딩 RNA가 마이크로RNA (miRNA), 안티센스 RNA, 짧은-간섭 RNA (siRNA) 또는 짧은-헤어핀 RNA (shRNA)인 방법.
  14. 제1항 내지 제13항 중 어느 한 항에 있어서, 제1 및/또는 제2 벡터가 플라스미드 벡터 또는 바이러스 벡터인 방법.
  15. (a) (i) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터; 및
    (b) (i) 선택가능한 마커 단백질의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터
    를 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 N-말단 단편 및 C-말단 단편의 연결을 촉매하여 전장 항생제 내성 단백질을 생성하는 것인 진핵생물 세포.
  16. (a) 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터; 및
    (b) 선택가능한 마커 단백질의 C-말단 단편으로부터 상류에 있는, 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터
    를 포함하며, 여기서 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 N-말단 단편 및 C-말단 단편의 연결을 촉매하여 전장 선택가능한 마커 단백질을 생성하는 것인 키트.
  17. (a) (i) 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터,
    (b) (i) 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질의 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, 및
    (c) (i) 선택가능한 마커 단백질의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제3 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제3 벡터
    를 진핵생물 세포로 전달하는 것을 포함하며, 여기서 제1 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 중심 단편으로의 선택가능한 마커 단백질의 N-말단 단편의 연결을 촉매하고, 제2 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 C-말단 단편으로의 선택가능한 마커 단백질의 중심 단편의 연결을 촉매하여 전장 선택가능한 마커 단백질을 생성하는 것인 방법.
  18. 제19항에 있어서, 트랜스제닉 진핵생물 세포를 생성하기 위해 진핵생물 세포로의 제1, 제2 및 제3 벡터의 도입을 허용하는 조건 하에 진핵생물 세포를 유지하는 것을 추가로 포함하는 방법.
  19. 제18항에 있어서, 전장 선택가능한 마커 단백질을 포함하는 트랜스제닉 진핵생물 세포를 선택하는 것을 추가로 포함하는 방법.
  20. (a) (i) 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제1 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터,
    (b) (i) 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질의 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제2 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, 및
    (c) (i) 선택가능한 마커 단백질의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열 및 (ii) 관심있는 제3 분자를 코딩하는 뉴클레오티드 서열을 포함하는 제3 벡터
    를 포함하며, 여기서 제1 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 중심 단편으로의 선택가능한 마커 단백질의 N-말단 단편의 연결을 촉매하고, 제2 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 C-말단 단편으로의 선택가능한 마커 단백질의 중심 단편의 연결을 촉매하여 전장 선택가능한 마커 단백질을 생성하는 것인 진핵생물 세포.
  21. (a) 제1 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질의 N-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제1 벡터,
    (b) 제2 인테인의 N-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 선택가능한 마커 단백질의 중심 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제1 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제2 벡터, 및
    (c) 선택가능한 마커 단백질의 C-말단 단편을 코딩하는 뉴클레오티드 서열로부터 상류에 있는, 제2 인테인의 C-말단 단편을 코딩하는 뉴클레오티드 서열을 포함하는 제3 벡터
    를 포함하며, 여기서 제1 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 중심 단편으로의 선택가능한 마커 단백질의 N-말단 단편의 연결을 촉매하고, 제2 인테인의 N-말단 단편 및 C-말단 단편은 선택가능한 마커 단백질의 C-말단 단편으로의 선택가능한 마커 단백질의 중심 단편의 연결을 촉매하여 전장 선택가능한 마커 단백질을 생성하는 것인 키트.
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