TW202304921A - 製造雙環酮化合物之方法 - Google Patents

製造雙環酮化合物之方法 Download PDF

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Publication number
TW202304921A
TW202304921A TW111112842A TW111112842A TW202304921A TW 202304921 A TW202304921 A TW 202304921A TW 111112842 A TW111112842 A TW 111112842A TW 111112842 A TW111112842 A TW 111112842A TW 202304921 A TW202304921 A TW 202304921A
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TW
Taiwan
Prior art keywords
compound
formula
stereoisomer
chiral
salt
Prior art date
Application number
TW111112842A
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English (en)
Chinese (zh)
Inventor
漢宇 洪
尼可拉斯 汪
勳 M 凱力
勞倫 伊莉莎白 西羅伊斯
莎拉 施韋格勒
欣 令狐
法蘭西斯 葛賽琳
卡泰辛納 愛勒珊卓 皮喬維奇
卡麥拉 莫里納洛
丹尼斯 威索
Original Assignee
美商建南德克公司
瑞士商赫孚孟拉羅股份公司
美商赫孚孟拉羅股份公司
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Application filed by 美商建南德克公司, 瑞士商赫孚孟拉羅股份公司, 美商赫孚孟拉羅股份公司 filed Critical 美商建南德克公司
Publication of TW202304921A publication Critical patent/TW202304921A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
TW111112842A 2021-04-02 2022-04-01 製造雙環酮化合物之方法 TW202304921A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163170422P 2021-04-02 2021-04-02
US63/170,422 2021-04-02

Publications (1)

Publication Number Publication Date
TW202304921A true TW202304921A (zh) 2023-02-01

Family

ID=81385014

Family Applications (1)

Application Number Title Priority Date Filing Date
TW111112842A TW202304921A (zh) 2021-04-02 2022-04-01 製造雙環酮化合物之方法

Country Status (13)

Country Link
US (1) US20240034739A1 (https=)
EP (1) EP4313986A1 (https=)
JP (1) JP2024513394A (https=)
KR (1) KR20230165238A (https=)
CN (1) CN117098762A (https=)
AR (1) AR125294A1 (https=)
AU (1) AU2022246900A1 (https=)
BR (1) BR112023020229A2 (https=)
CA (1) CA3214802A1 (https=)
IL (1) IL307250A (https=)
MX (1) MX2023011482A (https=)
TW (1) TW202304921A (https=)
WO (1) WO2022212809A1 (https=)

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3155107B2 (ja) 1993-01-12 2001-04-09 ダイセル化学工業株式会社 光学活性４−ハロ−３−ヒドロキシ酪酸エステルの製造方法
JPH08336393A (ja) 1995-04-13 1996-12-24 Mitsubishi Chem Corp 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法
JP3915015B2 (ja) 1995-08-22 2007-05-16 味の素株式会社 光学活性２−ヒドロキシ−４−アリール酪酸またはそのエステルの製造方法
CA2234913A1 (en) * 1995-10-18 1997-04-24 Paul E. Finke Cyclopentyl tachykinin receptor antagonists
US5891685A (en) 1996-06-03 1999-04-06 Mitsubishi Chemical Corporation Method for producing ester of (S)-γ-halogenated-β-hydroxybutyric acid
DE19857302C2 (de) 1998-12-14 2000-10-26 Forschungszentrum Juelich Gmbh Verfahren zur enantioselektiven Reduktion von 3,5-Dioxocarbonsäuren, deren Salze und Ester
JP4510351B2 (ja) 1999-12-03 2010-07-21 株式会社カネカ 新規カルボニル還元酵素、その遺伝子、およびその利用法
AU2007201854A1 (en) * 2000-10-17 2007-05-17 Merck Serono Sa Pharmaceutically active sulfanilide derivatives
MXPA03008437A (es) 2001-03-22 2004-01-29 Bristol Myers Squibb Co Reduccion estereoselectiva de acetofenona substituida.
JP4394647B2 (ja) 2003-12-02 2010-01-06 メルシャン株式会社 光学活性テトラヒドロチオフェン誘導体の製造方法、および、光学活性テトラヒドロチオフェン−３−オールの晶析方法
WO2006130657A2 (en) 2005-05-31 2006-12-07 Bristol-Myers Squibb Company Stereoselective reduction process for the preparation of pyrrolotriazine compounds
EP2115130B1 (en) 2007-02-08 2011-08-03 Codexis, Inc. Ketoreductases and uses thereof
JP2010070502A (ja) * 2008-09-19 2010-04-02 Daiichi Sankyo Co Ltd 抗真菌作用トリアゾロピリジン誘導体
CA2753696A1 (en) * 2009-02-26 2010-09-02 Noritaka Kitazawa Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors
TWI637951B (zh) 2013-02-15 2018-10-11 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺類
EP3317269B1 (en) * 2015-07-02 2022-09-21 F. Hoffmann-La Roche AG Bicyclic lactams as receptor-interacting protein-1 (rip1) kinase inhibitors for treating e.g. inflammatory diseases
US11071721B2 (en) * 2016-12-02 2021-07-27 Genentech, Inc. Bicyclic amide compounds and methods of use thereof
BR112020000771A2 (pt) * 2017-07-14 2020-07-14 F. Hoffmann-La Roche Ag compostos de cetona bicíclica e métodos de uso dos mesmos
RU2020114670A (ru) * 2017-10-11 2021-11-12 Ф. Хоффманн-Ля Рош Аг Бициклические соединения для применения в качестве ингибиторов rip1 киназы
CN113302193A (zh) * 2019-01-11 2021-08-24 豪夫迈·罗氏有限公司 双环吡咯并三唑酮化合物及其使用方法
CN111606890A (zh) * 2019-02-26 2020-09-01 微境生物医药科技(上海)有限公司 含丙烯酰基的核转运调节剂及其用途

Also Published As

Publication number Publication date
AR125294A1 (es) 2023-07-05
CA3214802A1 (en) 2022-10-06
MX2023011482A (es) 2023-10-03
IL307250A (en) 2023-11-01
BR112023020229A2 (pt) 2023-11-14
EP4313986A1 (en) 2024-02-07
AU2022246900A1 (en) 2023-09-14
CN117098762A (zh) 2023-11-21
KR20230165238A (ko) 2023-12-05
JP2024513394A (ja) 2024-03-25
AU2022246900A8 (en) 2023-09-21
US20240034739A1 (en) 2024-02-01
WO2022212809A1 (en) 2022-10-06

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