CN117098762A - 用于制备双环酮化合物的方法 - Google Patents

用于制备双环酮化合物的方法 Download PDF

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Publication number
CN117098762A
CN117098762A CN202280025356.3A CN202280025356A CN117098762A CN 117098762 A CN117098762 A CN 117098762A CN 202280025356 A CN202280025356 A CN 202280025356A CN 117098762 A CN117098762 A CN 117098762A
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CN
China
Prior art keywords
compound
formula
chiral
stereoisomer
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280025356.3A
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English (en)
Chinese (zh)
Inventor
A·Y·洪
N·王
S·M·凯利
L·E·西罗斯
S·施维格勒
X·令狐
F·戈斯林
K·A·皮乔维茨
C·莫利纳罗
D·维茨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Genentech Inc
Original Assignee
F Hoffmann La Roche AG
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Genentech Inc filed Critical F Hoffmann La Roche AG
Publication of CN117098762A publication Critical patent/CN117098762A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
CN202280025356.3A 2021-04-02 2022-04-01 用于制备双环酮化合物的方法 Pending CN117098762A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163170422P 2021-04-02 2021-04-02
US63/170,422 2021-04-02
PCT/US2022/022997 WO2022212809A1 (en) 2021-04-02 2022-04-01 Processes for making bicyclic ketone compounds

Publications (1)

Publication Number Publication Date
CN117098762A true CN117098762A (zh) 2023-11-21

Family

ID=81385014

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280025356.3A Pending CN117098762A (zh) 2021-04-02 2022-04-01 用于制备双环酮化合物的方法

Country Status (13)

Country Link
US (1) US20240034739A1 (https=)
EP (1) EP4313986A1 (https=)
JP (1) JP2024513394A (https=)
KR (1) KR20230165238A (https=)
CN (1) CN117098762A (https=)
AR (1) AR125294A1 (https=)
AU (1) AU2022246900A1 (https=)
BR (1) BR112023020229A2 (https=)
CA (1) CA3214802A1 (https=)
IL (1) IL307250A (https=)
MX (1) MX2023011482A (https=)
TW (1) TW202304921A (https=)
WO (1) WO2022212809A1 (https=)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2234913A1 (en) * 1995-10-18 1997-04-24 Paul E. Finke Cyclopentyl tachykinin receptor antagonists
AU2007201854A1 (en) * 2000-10-17 2007-05-17 Merck Serono Sa Pharmaceutically active sulfanilide derivatives
JP2010070502A (ja) * 2008-09-19 2010-04-02 Daiichi Sankyo Co Ltd 抗真菌作用トリアゾロピリジン誘導体
JP2012519152A (ja) * 2009-02-26 2012-08-23 エーザイ・アール・アンド・ディー・マネジメント株式会社 含窒素縮合複素環化合物及びベータアミロイド産生阻害剤としてのその使用
US20190100530A1 (en) * 2017-07-14 2019-04-04 Genentech, Inc. Bicyclic ketone compounds and methods of use thereof
CN110023313A (zh) * 2016-12-02 2019-07-16 豪夫迈·罗氏有限公司 二环酰胺化合物及其使用方法
CN111201229A (zh) * 2017-10-11 2020-05-26 豪夫迈·罗氏有限公司 用作rip1激酶抑制剂的二环化合物
WO2020146615A1 (en) * 2019-01-11 2020-07-16 Genentech, Inc. Bicyclic pyrrolotriazolr ketone compounds and methods of use thereof
WO2020173417A1 (zh) * 2019-02-26 2020-09-03 微境生物医药科技(上海)有限公司 含丙烯酰基的核转运调节剂及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3155107B2 (ja) 1993-01-12 2001-04-09 ダイセル化学工業株式会社 光学活性４−ハロ−３−ヒドロキシ酪酸エステルの製造方法
JPH08336393A (ja) 1995-04-13 1996-12-24 Mitsubishi Chem Corp 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法
JP3915015B2 (ja) 1995-08-22 2007-05-16 味の素株式会社 光学活性２−ヒドロキシ−４−アリール酪酸またはそのエステルの製造方法
US5891685A (en) 1996-06-03 1999-04-06 Mitsubishi Chemical Corporation Method for producing ester of (S)-γ-halogenated-β-hydroxybutyric acid
DE19857302C2 (de) 1998-12-14 2000-10-26 Forschungszentrum Juelich Gmbh Verfahren zur enantioselektiven Reduktion von 3,5-Dioxocarbonsäuren, deren Salze und Ester
JP4510351B2 (ja) 1999-12-03 2010-07-21 株式会社カネカ 新規カルボニル還元酵素、その遺伝子、およびその利用法
MXPA03008437A (es) 2001-03-22 2004-01-29 Bristol Myers Squibb Co Reduccion estereoselectiva de acetofenona substituida.
JP4394647B2 (ja) 2003-12-02 2010-01-06 メルシャン株式会社 光学活性テトラヒドロチオフェン誘導体の製造方法、および、光学活性テトラヒドロチオフェン−３−オールの晶析方法
WO2006130657A2 (en) 2005-05-31 2006-12-07 Bristol-Myers Squibb Company Stereoselective reduction process for the preparation of pyrrolotriazine compounds
EP2115130B1 (en) 2007-02-08 2011-08-03 Codexis, Inc. Ketoreductases and uses thereof
TWI637951B (zh) 2013-02-15 2018-10-11 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺類
EP3317269B1 (en) * 2015-07-02 2022-09-21 F. Hoffmann-La Roche AG Bicyclic lactams as receptor-interacting protein-1 (rip1) kinase inhibitors for treating e.g. inflammatory diseases

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2234913A1 (en) * 1995-10-18 1997-04-24 Paul E. Finke Cyclopentyl tachykinin receptor antagonists
AU2007201854A1 (en) * 2000-10-17 2007-05-17 Merck Serono Sa Pharmaceutically active sulfanilide derivatives
JP2010070502A (ja) * 2008-09-19 2010-04-02 Daiichi Sankyo Co Ltd 抗真菌作用トリアゾロピリジン誘導体
JP2012519152A (ja) * 2009-02-26 2012-08-23 エーザイ・アール・アンド・ディー・マネジメント株式会社 含窒素縮合複素環化合物及びベータアミロイド産生阻害剤としてのその使用
CN110023313A (zh) * 2016-12-02 2019-07-16 豪夫迈·罗氏有限公司 二环酰胺化合物及其使用方法
US20190100530A1 (en) * 2017-07-14 2019-04-04 Genentech, Inc. Bicyclic ketone compounds and methods of use thereof
CN111201229A (zh) * 2017-10-11 2020-05-26 豪夫迈·罗氏有限公司 用作rip1激酶抑制剂的二环化合物
WO2020146615A1 (en) * 2019-01-11 2020-07-16 Genentech, Inc. Bicyclic pyrrolotriazolr ketone compounds and methods of use thereof
WO2020173417A1 (zh) * 2019-02-26 2020-09-03 微境生物医药科技(上海)有限公司 含丙烯酰基的核转运调节剂及其用途

Also Published As

Publication number Publication date
AR125294A1 (es) 2023-07-05
CA3214802A1 (en) 2022-10-06
MX2023011482A (es) 2023-10-03
IL307250A (en) 2023-11-01
BR112023020229A2 (pt) 2023-11-14
EP4313986A1 (en) 2024-02-07
AU2022246900A1 (en) 2023-09-14
KR20230165238A (ko) 2023-12-05
TW202304921A (zh) 2023-02-01
JP2024513394A (ja) 2024-03-25
AU2022246900A8 (en) 2023-09-21
US20240034739A1 (en) 2024-02-01
WO2022212809A1 (en) 2022-10-06

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