TW202146007A - 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合 - Google Patents

包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合 Download PDF

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TW202146007A
TW202146007A TW110106633A TW110106633A TW202146007A TW 202146007 A TW202146007 A TW 202146007A TW 110106633 A TW110106633 A TW 110106633A TW 110106633 A TW110106633 A TW 110106633A TW 202146007 A TW202146007 A TW 202146007A
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compound
combination
pharmaceutically acceptable
cancer
dichlorophenyl
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TW110106633A
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Chinese (zh)
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蒙西夫 布阿布拉
竹燕 郭
史蒂芬 普里耶
梅松 索馬利
方憲 孫
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法商賽諾菲公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW110106633A 2020-02-27 2021-02-25 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合 TW202146007A (zh)

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EP20305190 2020-02-27
EP20305190.9 2020-02-27

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TW202146007A true TW202146007A (zh) 2021-12-16

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TW110106633A TW202146007A (zh) 2020-02-27 2021-02-25 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合

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US (1) US12427142B2 (enExample)
EP (1) EP4110326B1 (enExample)
JP (1) JP2023516951A (enExample)
KR (1) KR20220146473A (enExample)
CN (1) CN115209893B (enExample)
AR (1) AR121589A1 (enExample)
AU (1) AU2021227007A1 (enExample)
BR (1) BR112022015972A2 (enExample)
CA (1) CA3168936A1 (enExample)
IL (1) IL295807A (enExample)
MX (1) MX2022010539A (enExample)
TW (1) TW202146007A (enExample)
WO (1) WO2021170793A1 (enExample)

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EP4110326A1 (en) 2023-01-04
JP2023516951A (ja) 2023-04-21
IL295807A (en) 2022-10-01
CA3168936A1 (en) 2021-09-02
BR112022015972A2 (pt) 2022-10-11
US12427142B2 (en) 2025-09-30
WO2021170793A1 (en) 2021-09-02
EP4110326B1 (en) 2024-01-31
KR20220146473A (ko) 2022-11-01
CN115209893A (zh) 2022-10-18
CN115209893B (zh) 2024-08-30
EP4110326C0 (en) 2024-01-31
US20230089371A1 (en) 2023-03-23
MX2022010539A (es) 2022-09-21
AU2021227007A1 (en) 2022-10-20
AR121589A1 (es) 2022-06-22

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