MX2022010539A - Combinacion que comprende alpelisib y acido 6-(2,4-diclorofenil)-5 -[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro -7h-benzo[7]anulen-2-carboxilico. - Google Patents

Combinacion que comprende alpelisib y acido 6-(2,4-diclorofenil)-5 -[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro -7h-benzo[7]anulen-2-carboxilico.

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Publication number
MX2022010539A
MX2022010539A MX2022010539A MX2022010539A MX2022010539A MX 2022010539 A MX2022010539 A MX 2022010539A MX 2022010539 A MX2022010539 A MX 2022010539A MX 2022010539 A MX2022010539 A MX 2022010539A MX 2022010539 A MX2022010539 A MX 2022010539A
Authority
MX
Mexico
Prior art keywords
combination
alpelisib
oxyphenyl
fluoropropyl
dichlorophenyl
Prior art date
Application number
MX2022010539A
Other languages
English (en)
Inventor
Monsif Bouaboula
Zhuyan Guo
Maysoun Shomali
Fangxian Sun
Stéphane Poirier
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2022010539A publication Critical patent/MX2022010539A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

En el presente documento se proporcionan una combinación de alpelisib y de ácido 6-(2,4-diclorofenil)-5-[4-[(3S)-1-(3-fluoropr opil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7H-benzo[7]anulen-2-ca rboxílico o una sal farmacéuticamente aceptable del mismo, una composición farmacéutica que contiene una combinación de este tipo, y los usos terapéuticos de los mismos, en particular para el tratamiento del cáncer, incluyendo cáncer de mama.
MX2022010539A 2020-02-27 2021-02-26 Combinacion que comprende alpelisib y acido 6-(2,4-diclorofenil)-5 -[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro -7h-benzo[7]anulen-2-carboxilico. MX2022010539A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20305190 2020-02-27
PCT/EP2021/054815 WO2021170793A1 (en) 2020-02-27 2021-02-26 Combination comprising alpelisib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid

Publications (1)

Publication Number Publication Date
MX2022010539A true MX2022010539A (es) 2022-09-21

Family

ID=69784379

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022010539A MX2022010539A (es) 2020-02-27 2021-02-26 Combinacion que comprende alpelisib y acido 6-(2,4-diclorofenil)-5 -[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro -7h-benzo[7]anulen-2-carboxilico.

Country Status (13)

Country Link
US (1) US12427142B2 (es)
EP (1) EP4110326B1 (es)
JP (1) JP2023516951A (es)
KR (1) KR20220146473A (es)
CN (1) CN115209893B (es)
AR (1) AR121589A1 (es)
AU (1) AU2021227007A1 (es)
BR (1) BR112022015972A2 (es)
CA (1) CA3168936A1 (es)
IL (1) IL295807A (es)
MX (1) MX2022010539A (es)
TW (1) TW202146007A (es)
WO (1) WO2021170793A1 (es)

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ES2923412T3 (es) 2018-09-07 2022-09-27 Sanofi Sa Sales de 6-(2,4-diclorofenil)-5-[4-[(3S)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7H-benzo[7]anuleno-2-carboxilato de metilo y proceso de preparación de las mismas
JP7680438B2 (ja) 2019-10-01 2025-05-20 サノフイ 新規の置換６，７－ジヒドロ－５ｈ－ベンゾ［７］アンヌレン化合物、その製造方法およびその治療的使用
BR112022009705A2 (pt) 2019-12-09 2022-08-09 Sanofi Sa Forma cristalina anidra de um derivado de ácido 7h-benzo[7]anuleno-2-carboxílico, seus usos e processos de preparação, forma sólida, medicamento e composição farmacêutica
US12595230B2 (en) 2020-10-19 2026-04-07 Sanofi Substituted 6,7-dihydro-5H-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof
AU2021366223A1 (en) 2020-10-19 2023-06-22 Sanofi Substituted 6,7-dihydro-5h-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof
US12558428B2 (en) 2024-03-08 2026-02-24 Halda Therapeutics Opco, Inc. Heterobifunctional compounds and their use in treating disease

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Also Published As

Publication number Publication date
EP4110326A1 (en) 2023-01-04
KR20220146473A (ko) 2022-11-01
AR121589A1 (es) 2022-06-22
EP4110326C0 (en) 2024-01-31
US20230089371A1 (en) 2023-03-23
AU2021227007A1 (en) 2022-10-20
US12427142B2 (en) 2025-09-30
TW202146007A (zh) 2021-12-16
IL295807A (en) 2022-10-01
CA3168936A1 (en) 2021-09-02
CN115209893B (zh) 2024-08-30
WO2021170793A1 (en) 2021-09-02
BR112022015972A2 (pt) 2022-10-11
EP4110326B1 (en) 2024-01-31
JP2023516951A (ja) 2023-04-21
CN115209893A (zh) 2022-10-18

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