KR20220146473A - 알펠리십과 6-(2,4-디클로로페닐)-5-[4-[(3s)-1-(3-플루오로프로필)피롤리딘-3-일]옥시페닐]-8,9-디히드로-7h-벤조[7]아눌렌-2-카복실산을 포함하는 병용물 - Google Patents

알펠리십과 6-(2,4-디클로로페닐)-5-[4-[(3s)-1-(3-플루오로프로필)피롤리딘-3-일]옥시페닐]-8,9-디히드로-7h-벤조[7]아눌렌-2-카복실산을 포함하는 병용물 Download PDF

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KR20220146473A
KR20220146473A KR1020227029446A KR20227029446A KR20220146473A KR 20220146473 A KR20220146473 A KR 20220146473A KR 1020227029446 A KR1020227029446 A KR 1020227029446A KR 20227029446 A KR20227029446 A KR 20227029446A KR 20220146473 A KR20220146473 A KR 20220146473A
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South Korea
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alfelisib
compound
pharmaceutically acceptable
cancer
fluoropropyl
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KR1020227029446A
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Korean (ko)
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몬시프 보우아보울라
주옌 궈
스테판 포아리에
메이소운 쇼말리
팡시엔 쑨
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사노피
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020227029446A 2020-02-27 2021-02-26 알펠리십과 6-(2,4-디클로로페닐)-5-[4-[(3s)-1-(3-플루오로프로필)피롤리딘-3-일]옥시페닐]-8,9-디히드로-7h-벤조[7]아눌렌-2-카복실산을 포함하는 병용물 Withdrawn KR20220146473A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20305190 2020-02-27
EP20305190.9 2020-02-27
PCT/EP2021/054815 WO2021170793A1 (en) 2020-02-27 2021-02-26 Combination comprising alpelisib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid

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KR20220146473A true KR20220146473A (ko) 2022-11-01

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KR1020227029446A Withdrawn KR20220146473A (ko) 2020-02-27 2021-02-26 알펠리십과 6-(2,4-디클로로페닐)-5-[4-[(3s)-1-(3-플루오로프로필)피롤리딘-3-일]옥시페닐]-8,9-디히드로-7h-벤조[7]아눌렌-2-카복실산을 포함하는 병용물

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US (1) US12427142B2 (enExample)
EP (1) EP4110326B1 (enExample)
JP (1) JP2023516951A (enExample)
KR (1) KR20220146473A (enExample)
CN (1) CN115209893B (enExample)
AR (1) AR121589A1 (enExample)
AU (1) AU2021227007A1 (enExample)
BR (1) BR112022015972A2 (enExample)
CA (1) CA3168936A1 (enExample)
IL (1) IL295807A (enExample)
MX (1) MX2022010539A (enExample)
TW (1) TW202146007A (enExample)
WO (1) WO2021170793A1 (enExample)

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EP4110326A1 (en) 2023-01-04
JP2023516951A (ja) 2023-04-21
IL295807A (en) 2022-10-01
CA3168936A1 (en) 2021-09-02
TW202146007A (zh) 2021-12-16
BR112022015972A2 (pt) 2022-10-11
US12427142B2 (en) 2025-09-30
WO2021170793A1 (en) 2021-09-02
EP4110326B1 (en) 2024-01-31
CN115209893A (zh) 2022-10-18
CN115209893B (zh) 2024-08-30
EP4110326C0 (en) 2024-01-31
US20230089371A1 (en) 2023-03-23
MX2022010539A (es) 2022-09-21
AU2021227007A1 (en) 2022-10-20
AR121589A1 (es) 2022-06-22

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