TW202100526A - 吡咯并吡唑衍生物 - Google Patents
吡咯并吡唑衍生物 Download PDFInfo
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- TW202100526A TW202100526A TW109107195A TW109107195A TW202100526A TW 202100526 A TW202100526 A TW 202100526A TW 109107195 A TW109107195 A TW 109107195A TW 109107195 A TW109107195 A TW 109107195A TW 202100526 A TW202100526 A TW 202100526A
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- Prior art keywords
- cancer
- phenyl
- formula
- trifluoromethyl
- phenoxy
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- GZTPJDLYPMPRDF-UHFFFAOYSA-N pyrrolo[3,2-c]pyrazole Chemical class N1=NC2=CC=NC2=C1 GZTPJDLYPMPRDF-UHFFFAOYSA-N 0.000 title description 2
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- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 118
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- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 108
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 108
- 125000001424 substituent group Chemical group 0.000 claims description 85
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- FKFDZMXJTBHJSX-UHFFFAOYSA-N 7-[5-(2,2-difluoropropyl)-6-oxo-4-[4-[4-(trifluoromethoxy)-3-(trifluoromethyl)phenoxy]phenyl]-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3H-1,3-benzoxazol-2-one Chemical compound FC(CN1C(C=2NN=C(C2C1C1=CC=C(C=C1)OC1=CC(=C(C=C1)OC(F)(F)F)C(F)(F)F)C1=CC=CC=2NC(OC21)=O)=O)(C)F FKFDZMXJTBHJSX-UHFFFAOYSA-N 0.000 claims description 5
- WNVIHMCTUXYTDH-UHFFFAOYSA-N 7-[5-(2,2-difluoropropyl)-6-oxo-4-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3H-1,3-benzoxazol-2-one Chemical compound CC(CN1C(C2=C(C1=O)NN=C2C3=C4C(=CC=C3)NC(=O)O4)C5=CC=C(C=C5)OC6=CC=C(C=C6)OC(F)(F)F)(F)F WNVIHMCTUXYTDH-UHFFFAOYSA-N 0.000 claims description 5
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- Engineering & Computer Science (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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