TW202038920A - 發泡性經口固形製劑 - Google Patents
發泡性經口固形製劑 Download PDFInfo
- Publication number
- TW202038920A TW202038920A TW108147568A TW108147568A TW202038920A TW 202038920 A TW202038920 A TW 202038920A TW 108147568 A TW108147568 A TW 108147568A TW 108147568 A TW108147568 A TW 108147568A TW 202038920 A TW202038920 A TW 202038920A
- Authority
- TW
- Taiwan
- Prior art keywords
- mass
- component
- less
- acid
- mmol
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 86
- 239000007787 solid Substances 0.000 title claims abstract description 84
- 239000002253 acid Substances 0.000 claims abstract description 51
- 150000003839 salts Chemical class 0.000 claims abstract description 26
- 239000000284 extract Substances 0.000 claims abstract description 24
- 150000007524 organic acids Chemical class 0.000 claims abstract description 20
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims abstract description 15
- 235000013599 spices Nutrition 0.000 claims abstract description 14
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 32
- 239000004615 ingredient Substances 0.000 claims description 24
- 235000020708 ginger extract Nutrition 0.000 claims description 23
- 229940002508 ginger extract Drugs 0.000 claims description 23
- 229960005070 ascorbic acid Drugs 0.000 claims description 14
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 9
- 150000005846 sugar alcohols Chemical class 0.000 claims description 9
- 235000010323 ascorbic acid Nutrition 0.000 claims description 8
- 239000011668 ascorbic acid Substances 0.000 claims description 8
- 229940007061 capsicum extract Drugs 0.000 claims description 4
- 239000001943 capsicum frutescens fruit extract Substances 0.000 claims description 4
- 210000001913 submandibular gland Anatomy 0.000 abstract description 69
- 230000028327 secretion Effects 0.000 abstract description 67
- 210000003296 saliva Anatomy 0.000 abstract description 60
- 210000004400 mucous membrane Anatomy 0.000 abstract description 12
- 210000003670 sublingual gland Anatomy 0.000 abstract description 3
- 210000003298 dental enamel Anatomy 0.000 abstract description 2
- 230000006735 deficit Effects 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 42
- NLDDIKRKFXEWBK-AWEZNQCLSA-N gingerol Chemical compound CCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 NLDDIKRKFXEWBK-AWEZNQCLSA-N 0.000 description 37
- JZLXEKNVCWMYHI-UHFFFAOYSA-N gingerol Natural products CCCCC(O)CC(=O)CCC1=CC=C(O)C(OC)=C1 JZLXEKNVCWMYHI-UHFFFAOYSA-N 0.000 description 37
- 230000002688 persistence Effects 0.000 description 25
- 230000000052 comparative effect Effects 0.000 description 21
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 20
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 20
- 238000000034 method Methods 0.000 description 20
- 239000003826 tablet Substances 0.000 description 19
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 18
- 238000005187 foaming Methods 0.000 description 18
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 14
- 235000015165 citric acid Nutrition 0.000 description 14
- 238000011156 evaluation Methods 0.000 description 13
- 238000005469 granulation Methods 0.000 description 13
- 230000003179 granulation Effects 0.000 description 13
- 238000004128 high performance liquid chromatography Methods 0.000 description 13
- 238000004458 analytical method Methods 0.000 description 12
- 239000007937 lozenge Substances 0.000 description 12
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- 239000000845 maltitol Substances 0.000 description 11
- 235000010449 maltitol Nutrition 0.000 description 11
- 229940035436 maltitol Drugs 0.000 description 11
- 230000001953 sensory effect Effects 0.000 description 11
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 10
- 235000013539 calcium stearate Nutrition 0.000 description 10
- 239000008116 calcium stearate Substances 0.000 description 10
- 239000001913 cellulose Substances 0.000 description 10
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 10
- 235000017557 sodium bicarbonate Nutrition 0.000 description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 235000017663 capsaicin Nutrition 0.000 description 9
- 229960002504 capsaicin Drugs 0.000 description 9
- 229920003124 powdered cellulose Polymers 0.000 description 9
- 235000019814 powdered cellulose Nutrition 0.000 description 9
- 239000000377 silicon dioxide Substances 0.000 description 9
- 235000012239 silicon dioxide Nutrition 0.000 description 9
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 8
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 7
- 239000001569 carbon dioxide Substances 0.000 description 7
- 229910002092 carbon dioxide Inorganic materials 0.000 description 7
- 238000000605 extraction Methods 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 239000011975 tartaric acid Substances 0.000 description 7
- 235000002906 tartaric acid Nutrition 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 6
- 239000002211 L-ascorbic acid Substances 0.000 description 6
- 235000000069 L-ascorbic acid Nutrition 0.000 description 6
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 6
- 229940093915 gynecological organic acid Drugs 0.000 description 6
- 235000005985 organic acids Nutrition 0.000 description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 6
- 206010039424 Salivary hypersecretion Diseases 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 210000002200 mouth mucosa Anatomy 0.000 description 5
- 229940116257 pepper extract Drugs 0.000 description 5
- 208000026451 salivation Diseases 0.000 description 5
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 5
- FCSSPCOFDUKHPV-UHFFFAOYSA-N 2-Propenyl propyl disulfide Chemical compound CCCSSCC=C FCSSPCOFDUKHPV-UHFFFAOYSA-N 0.000 description 4
- ATKWJXUJUNLTFU-UHFFFAOYSA-N 4-Hydroxybenzyl isothiocyanate Chemical compound OC1=CC=C(CN=C=S)C=C1 ATKWJXUJUNLTFU-UHFFFAOYSA-N 0.000 description 4
- 235000002566 Capsicum Nutrition 0.000 description 4
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 4
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 4
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 4
- ZOJBYZNEUISWFT-UHFFFAOYSA-N allyl isothiocyanate Chemical compound C=CCN=C=S ZOJBYZNEUISWFT-UHFFFAOYSA-N 0.000 description 4
- 230000000840 anti-viral effect Effects 0.000 description 4
- NEHNMFOYXAPHSD-UHFFFAOYSA-N citronellal Chemical compound O=CCC(C)CCC=C(C)C NEHNMFOYXAPHSD-UHFFFAOYSA-N 0.000 description 4
- PFRGXCVKLLPLIP-UHFFFAOYSA-N diallyl disulfide Chemical compound C=CCSSCC=C PFRGXCVKLLPLIP-UHFFFAOYSA-N 0.000 description 4
- UBAXRAHSPKWNCX-UHFFFAOYSA-N diallyl trisulfide Chemical compound C=CCSSSCC=C UBAXRAHSPKWNCX-UHFFFAOYSA-N 0.000 description 4
- -1 etc.) Substances 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 4
- 210000004877 mucosa Anatomy 0.000 description 4
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 4
- WVWHRXVVAYXKDE-UHFFFAOYSA-N piperine Natural products O=C(C=CC=Cc1ccc2OCOc2c1)C3CCCCN3 WVWHRXVVAYXKDE-UHFFFAOYSA-N 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 description 4
- 235000017550 sodium carbonate Nutrition 0.000 description 4
- 235000014620 theaflavin Nutrition 0.000 description 4
- 238000009210 therapy by ultrasound Methods 0.000 description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 3
- 235000002568 Capsicum frutescens Nutrition 0.000 description 3
- 241001562081 Ikeda Species 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 3
- 241000234314 Zingiber Species 0.000 description 3
- 235000006886 Zingiber officinale Nutrition 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 235000013325 dietary fiber Nutrition 0.000 description 3
- 210000005069 ears Anatomy 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 239000013022 formulation composition Substances 0.000 description 3
- 239000001530 fumaric acid Substances 0.000 description 3
- 235000011087 fumaric acid Nutrition 0.000 description 3
- 235000008397 ginger Nutrition 0.000 description 3
- 239000001630 malic acid Substances 0.000 description 3
- 235000011090 malic acid Nutrition 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 229960003975 potassium Drugs 0.000 description 3
- 229910000027 potassium carbonate Inorganic materials 0.000 description 3
- 235000011181 potassium carbonates Nutrition 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 235000013311 vegetables Nutrition 0.000 description 3
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 2
- MXXWOMGUGJBKIW-BPMFVRGZSA-N (2z,4e)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one Chemical compound C=1C=C2OCOC2=CC=1\C=C\C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-BPMFVRGZSA-N 0.000 description 2
- AAWZDTNXLSGCEK-LNVDRNJUSA-N (3r,5r)-1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid Chemical compound O[C@@H]1CC(O)(C(O)=O)C[C@@H](O)C1O AAWZDTNXLSGCEK-LNVDRNJUSA-N 0.000 description 2
- 239000001169 1-methyl-4-propan-2-ylcyclohexa-1,4-diene Substances 0.000 description 2
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 2
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 description 2
- 244000056139 Brassica cretica Species 0.000 description 2
- 235000003351 Brassica cretica Nutrition 0.000 description 2
- 235000003343 Brassica rupestris Nutrition 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 240000008574 Capsicum frutescens Species 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- AAWZDTNXLSGCEK-UHFFFAOYSA-N Cordycepinsaeure Natural products OC1CC(O)(C(O)=O)CC(O)C1O AAWZDTNXLSGCEK-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-DUZGATOHSA-N D-araboascorbic acid Natural products OC[C@@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-DUZGATOHSA-N 0.000 description 2
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 2
- ODBLHEXUDAPZAU-ZAFYKAAXSA-N D-threo-isocitric acid Chemical compound OC(=O)[C@H](O)[C@@H](C(O)=O)CC(O)=O ODBLHEXUDAPZAU-ZAFYKAAXSA-N 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 2
- 239000005792 Geraniol Substances 0.000 description 2
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 229920001144 Hydroxy alpha sanshool Polymers 0.000 description 2
- ODBLHEXUDAPZAU-FONMRSAGSA-N Isocitric acid Natural products OC(=O)[C@@H](O)[C@H](C(O)=O)CC(O)=O ODBLHEXUDAPZAU-FONMRSAGSA-N 0.000 description 2
- IPMYMEWFZKHGAX-UHFFFAOYSA-N Isotheaflavin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C(C1=C2)=CC(O)=C(O)C1=C(O)C(=O)C=C2C1C(O)CC2=C(O)C=C(O)C=C2O1 IPMYMEWFZKHGAX-UHFFFAOYSA-N 0.000 description 2
- 239000006002 Pepper Substances 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 241000722363 Piper Species 0.000 description 2
- 235000016761 Piper aduncum Nutrition 0.000 description 2
- 235000017804 Piper guineense Nutrition 0.000 description 2
- 235000008184 Piper nigrum Nutrition 0.000 description 2
- AAWZDTNXLSGCEK-ZHQZDSKASA-N Quinic acid Natural products O[C@H]1CC(O)(C(O)=O)C[C@H](O)C1O AAWZDTNXLSGCEK-ZHQZDSKASA-N 0.000 description 2
- PSKIOIDCXFHNJA-UHFFFAOYSA-N Sanshool Natural products CC=CC=CC=CCCC=CC=CC(=O)NC(C)C PSKIOIDCXFHNJA-UHFFFAOYSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- UXRMWRBWCAGDQB-UHFFFAOYSA-N Theaflavin Natural products C1=CC(C2C(CC3=C(O)C=C(O)C=C3O2)O)=C(O)C(=O)C2=C1C(C1OC3=CC(O)=CC(O)=C3CC1O)=CC(O)=C2O UXRMWRBWCAGDQB-UHFFFAOYSA-N 0.000 description 2
- 240000002657 Thymus vulgaris Species 0.000 description 2
- 235000007303 Thymus vulgaris Nutrition 0.000 description 2
- 208000036142 Viral infection Diseases 0.000 description 2
- 235000010724 Wisteria floribunda Nutrition 0.000 description 2
- 239000001361 adipic acid Substances 0.000 description 2
- 235000011037 adipic acid Nutrition 0.000 description 2
- 235000016720 allyl isothiocyanate Nutrition 0.000 description 2
- SBXYHCVXUCYYJT-UEOYEZOQSA-N alpha-Sanshool Chemical compound C\C=C\C=C\C=C/CC\C=C\C(=O)NCC(C)C SBXYHCVXUCYYJT-UEOYEZOQSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 2
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 description 2
- 229940116229 borneol Drugs 0.000 description 2
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000001390 capsicum minimum Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 229960005233 cineole Drugs 0.000 description 2
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 description 2
- MXXWOMGUGJBKIW-SRRWRRMSSA-N cis-trans-Piperin Natural products O=C(C=C/C=C/c1ccc2OCOc2c1)N3CCCCC3 MXXWOMGUGJBKIW-SRRWRRMSSA-N 0.000 description 2
- 229930003633 citronellal Natural products 0.000 description 2
- 235000000983 citronellal Nutrition 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000004318 erythorbic acid Substances 0.000 description 2
- 235000010350 erythorbic acid Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 229940113087 geraniol Drugs 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000000174 gluconic acid Substances 0.000 description 2
- 235000012208 gluconic acid Nutrition 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 229940026239 isoascorbic acid Drugs 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
- 239000011976 maleic acid Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 235000010460 mustard Nutrition 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 229940100629 oral lozenge Drugs 0.000 description 2
- 235000006408 oxalic acid Nutrition 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 210000003681 parotid gland Anatomy 0.000 description 2
- 150000007875 phellandrene derivatives Chemical class 0.000 description 2
- MXXWOMGUGJBKIW-YPCIICBESA-N piperine Chemical compound C=1C=C2OCOC2=CC=1/C=C/C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-YPCIICBESA-N 0.000 description 2
- 235000019100 piperine Nutrition 0.000 description 2
- 229940075559 piperine Drugs 0.000 description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 2
- 235000015497 potassium bicarbonate Nutrition 0.000 description 2
- 239000011736 potassium bicarbonate Substances 0.000 description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 235000019633 pungent taste Nutrition 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 229910000031 sodium sesquicarbonate Inorganic materials 0.000 description 2
- 235000018341 sodium sesquicarbonate Nutrition 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- IPMYMEWFZKHGAX-ZKSIBHASSA-N theaflavin Chemical compound C1=C2C([C@H]3OC4=CC(O)=CC(O)=C4C[C@H]3O)=CC(O)=C(O)C2=C(O)C(=O)C=C1[C@@H]1[C@H](O)CC2=C(O)C=C(O)C=C2O1 IPMYMEWFZKHGAX-ZKSIBHASSA-N 0.000 description 2
- 229940026509 theaflavin Drugs 0.000 description 2
- ODBLHEXUDAPZAU-UHFFFAOYSA-N threo-D-isocitric acid Natural products OC(=O)C(O)C(C(O)=O)CC(O)=O ODBLHEXUDAPZAU-UHFFFAOYSA-N 0.000 description 2
- 239000001585 thymus vulgaris Substances 0.000 description 2
- WCTAGTRAWPDFQO-UHFFFAOYSA-K trisodium;hydrogen carbonate;carbonate Chemical compound [Na+].[Na+].[Na+].OC([O-])=O.[O-]C([O-])=O WCTAGTRAWPDFQO-UHFFFAOYSA-K 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 description 1
- OQWKEEOHDMUXEO-UHFFFAOYSA-N (6)-shogaol Natural products CCCCCC=CC(=O)CCC1=CC=C(O)C(OC)=C1 OQWKEEOHDMUXEO-UHFFFAOYSA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 240000002234 Allium sativum Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 description 1
- 239000006000 Garlic extract Substances 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 240000009164 Petroselinum crispum Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 239000004373 Pullulan Substances 0.000 description 1
- 229920001218 Pullulan Polymers 0.000 description 1
- PHZOWSSBXJXFOR-MYMDCHNCSA-N Sinigrin Natural products S(=O)(=O)(O/N=C(\S[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O1)/CC=C)O PHZOWSSBXJXFOR-MYMDCHNCSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 244000228451 Stevia rebaudiana Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 244000131415 Zanthoxylum piperitum Species 0.000 description 1
- 235000008853 Zanthoxylum piperitum Nutrition 0.000 description 1
- OQWKEEOHDMUXEO-BQYQJAHWSA-N [6]-Shogaol Chemical compound CCCCC\C=C\C(=O)CCC1=CC=C(O)C(OC)=C1 OQWKEEOHDMUXEO-BQYQJAHWSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 150000008065 acid anhydrides Chemical class 0.000 description 1
- 229960000250 adipic acid Drugs 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000001099 ammonium carbonate Substances 0.000 description 1
- 235000012501 ammonium carbonate Nutrition 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 description 1
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 description 1
- 235000007746 carvacrol Nutrition 0.000 description 1
- 150000001765 catechin Chemical class 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 229960001681 croscarmellose sodium Drugs 0.000 description 1
- 229960000913 crospovidone Drugs 0.000 description 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 238000004332 deodorization Methods 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 description 1
- 150000001991 dicarboxylic acids Chemical class 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940030275 epigallocatechin gallate Drugs 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229960002598 fumaric acid Drugs 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- 235000020706 garlic extract Nutrition 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000002780 gingerol Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 125000004383 glucosinolate group Chemical group 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 238000000622 liquid--liquid extraction Methods 0.000 description 1
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229940098895 maleic acid Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000000874 microwave-assisted extraction Methods 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000012454 non-polar solvent Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- HEHINIICWNIGNO-UHFFFAOYSA-N oxosilicon;titanium Chemical compound [Ti].[Si]=O HEHINIICWNIGNO-UHFFFAOYSA-N 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 235000011197 perejil Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 229940112950 sage extract Drugs 0.000 description 1
- 235000020752 sage extract Nutrition 0.000 description 1
- 210000003079 salivary gland Anatomy 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- PHZOWSSBXJXFOR-PTGZALFTSA-N sinigrin Chemical compound OC[C@H]1O[C@@H](S\C(CC=C)=N\OS(O)(=O)=O)[C@H](O)[C@@H](O)[C@@H]1O PHZOWSSBXJXFOR-PTGZALFTSA-N 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- CLJTZNIHUYFUMR-UHFFFAOYSA-M sodium;hydrogen carbonate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].OC([O-])=O.OC(=O)CC(O)(C(O)=O)CC(O)=O CLJTZNIHUYFUMR-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/50—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by shape, structure or physical form, e.g. products with supported structure
- A23G3/52—Aerated, foamed, cellular or porous products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/10—Natural spices, flavouring agents or condiments; Extracts thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/20—Ingredients acting on or related to the structure
- A23V2200/226—Foaming agent
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Medicinal Preparation (AREA)
- Confectionery (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本發明提供一種發泡性經口固形製劑，其提高舌、頜下腺唾液之分泌，使該舌、頜下腺唾液之分泌持續且對口腔黏膜或牙齒之牙釉質無危害性。 本發明之發泡性經口固形製劑含有以下之成分(A)、(B)及(C)： (A)香辛料萃取物 0.001質量%以上且0.11質量%以下 (B)碳酸鹽 7質量%以上且40質量%以下 (C)有機酸或其鹽，且 成分(C)之酸基之莫耳數為50 mmol/100 g以上且600 mmol/100 g以下，成分(B)之莫耳數(mol)與成分(C)之酸基之莫耳數(mol)的比[(B)之莫耳數(mol)/(C)之酸基之莫耳數(mol)]為0.25以上且3.0以下。
Description
本發明係關於一種發泡性經口固形製劑。
已知唾液對於維持口腔內之恆常性較為重要，具有自淨作用、緩衝作用、保護黏膜作用、抗菌/抗病毒作用。唾液腺主要有3個，即朝臉頰內側之黏膜開口之腮腺、朝舌下開口之舌下腺、及頜下腺。報告有如下情況：唾液之抗病毒作用在來自舌、頜下腺之唾液中之效果高於在來自腮腺之唾液中之效果(非專利文獻1)。由此可知，為了提高唾液之抗病毒效果而預防病毒感染症，促進舌、頜下腺唾液之分泌尤其有用。
迄今為止，報告有利用有機酸及碳酸鹽或碳酸氫鹽之碳酸發泡(專利文獻1)、屬於山椒屬之植物之果實、其粉碎物、其壓榨物或其等之萃取物(專利文獻2)會促進唾液分泌，提出有調配有發泡成分及香辛料萃取物之經口固形製劑。
(專利文獻1)日本專利特開2002-184號公報 (專利文獻2)日本專利特開2011-68642號公報
(非專利文獻1)Oral Microbiology Immunology 2009年、24(1)、p.18-24
本發明提供一種發泡性經口固形製劑，其含有以下之成分(A)、(B)及(C)： (A)香辛料萃取物 0.001質量%以上且0.11質量%以下 (B)碳酸鹽 7質量%以上且40質量%以下 (C)有機酸或其鹽，且 成分(C)之酸基之莫耳數為50 mmol/100 g以上且600 mmol/100 g以下，成分(B)之莫耳數(mol)與成分(C)之酸基之莫耳數(mol)的比[(B)鹽之莫耳數(mol)/(C)之酸基之莫耳數(mol)]為0.25以上且3.0以下。
然而，有機酸之黏膜刺激性較強，無法為了提高唾液分泌量而調配足夠之量，又，會對口腔黏膜等產生危害性。又，發現利用有機酸及碳酸鹽或碳酸氫鹽之碳酸發泡存在唾液分泌不持續之問題。進而，關於藉由與香辛料萃取物組合所產生之舌、頜下腺唾液之分泌促進效果還未驗證。 本發明係關於提供一種發泡性經口固形製劑，其提高舌、頜下腺唾液之分泌，使該舌、頜下腺唾液之分泌持續，且對口腔黏膜無危害性。
本發明者進行了銳意研究，結果發現：藉由以特定量含有香辛料萃取物、碳酸鹽及有機酸或其鹽，且將碳酸鹽之莫耳數與有機酸或其鹽之酸基之莫耳數設為特定比，可獲得一種發泡性經口固形製劑，其不會對口腔黏膜等產生危害性，提高舌、頜下腺唾液之分泌，且其持續性亦優異。
根據本發明，可提供一種提高舌、頜下腺唾液之分泌，且使該舌、頜下腺唾液之分泌持續之發泡性經口固形製劑。本發明之發泡性經口固形製劑對口腔黏膜或牙齒之牙釉質無危害性，因此使用感亦良好。
於本說明書中，「發泡性經口固形製劑」意指於口腔內與唾液等水分接觸而產生二氧化碳之於20℃±15℃下為固形狀態之製劑。作為具體之製劑(劑型)，例如可列舉錠劑(包括咀嚼錠等)、膠囊劑、顆粒劑、散劑、口含劑等。其中，就提高舌、頜下腺唾液分泌量之觀點、及提高舌、頜下腺唾液之分泌持續性之觀點而言，較佳為錠劑或口含劑，更佳為口含劑。
本發明之發泡性經口固形製劑含有香辛料萃取物作為成分(A)。 於本說明書中，「香辛料萃取物」係自香辛料獲得之萃取物，於常溫下可為液狀、固形狀、半固形狀之任一種形態。 香辛料並無特別限制，可使用自植物之種子、果實、葉、花、蕾、莖、樹皮、根塊、根莖等部位所製備者，例如可列舉胡椒、薑、辣椒、山崳菜、芥末、鼠尾草、百里香、山椒、蒜等。該等可使用1種或將2種以上組合而使用。其中，就提高舌、頜下腺唾液之分泌持續性之觀點而言，較佳為薑、辣椒，更佳為薑。
獲得香辛料萃取物之萃取方法可為浸漬、煎出、浸出、回流萃取、蒸餾、超臨界萃取、超音波萃取、微波萃取等之任一種。 萃取溶劑可為極性溶劑、非極性溶劑之任一種，例如可列舉：水；甲醇、乙醇等醇類；次臨界或超臨界二氧化碳；油脂、蠟等其他油類；以及該等之混合物。 關於萃取中之溶劑之使用量、萃取條件，只要為可進行充分萃取之條件，則無特別限定，可適當地進行調整。 香辛料萃取物可為粗純化物，亦可為視需要藉由液液分配、固液分配、過濾膜、活性炭、吸附樹脂、離子交換樹脂、澱出等公知之技術實施了非活性之夾雜物之去除、除臭、脫色等處理者。又，亦可適當地將公知之分離純化方法進行組合而提高純度。作為純化方法，可列舉有機溶劑沈澱、離心分離、限界濾膜、高效液相層析法或管柱層析法等。 香辛料萃取物可使用6-薑酚(6-Gingerol)(富士膠片和光純藥工業(股)，純度100%)、6-薑醇(6-Shogaol)(富士膠片和光純藥工業(股)，純度100%)等市售品，又，亦可使用薑萃取物粉末E(池田糖化工業(股))等利用糊精或麥芽糖醇等賦形劑將萃取物進行粉末化而成者等。
於成分(A)為薑萃取物之情形時，亦可分別單獨含有6-薑酚及6-薑醇，但較佳為含有6-薑酚及6-薑醇。就提高舌、頜下腺唾液之分泌持續性之觀點而言，薑萃取物較佳為相對於薑萃取物總量含有合計50質量%以上之6-薑酚及6-薑醇，更佳為含有80質量%以上，進而較佳為含有100質量%。即，薑萃取物較佳為6-薑酚及6-薑醇。 又，於成分(A)為辣椒萃取物之情形時，較佳為含有辣椒素。就提高舌、頜下腺唾液之分泌持續性之觀點而言，辣椒萃取物較佳為相對於辣椒萃取物總量含有50質量%以上之辣椒素，更佳為含有80質量%以上，進而較佳為含有100質量%。即，辣椒萃取物較佳為辣椒素。 6-薑酚及6-薑醇、以及辣椒素可依照以下揭示之實施例中所記載之方法進行分析。
同樣地，於成分(A)為胡椒萃取物之情形時，較佳為含有異胡椒鹼及胡椒鹼，於成分(A)為山崳菜萃取物之情形時，較佳為含有黑芥酸鉀，於成分(A)為芥末萃取物之情形時，較佳為含有黑芥酸鉀、異硫氰酸烯丙酯、白芥苷及異硫氰酸對羥基苄酯，於成分(A)為鼠尾草萃取物之情形時，較佳為含有shravan、蒎烯、桉樹腦及冰片，於成分(A)為百里香萃取物之情形時，較佳為含有瑞香草酚及香旱芹酚，山椒萃取物之有效成分較佳為含有山椒醇、雙戊烯、香茅醛、香葉草醇及水芹烯，於成分(A)為蒜萃取物之情形時，較佳為含有二烯丙基二硫醚、丙基烯丙基二硫醚及二烯丙基三硫醚。上述各萃取物較佳為相對於萃取物總量含有50質量%以上之上述各成分，更佳為含有80質量%以上，進而較佳為含有100質量%。異胡椒鹼、胡椒鹼、黑芥酸鉀、異硫氰酸烯丙酯、白芥苷、異硫氰酸對羥基苄酯、shravan、蒎烯、桉樹腦、冰片、瑞香草酚、香旱芹酚、山椒醇、雙戊烯、香茅醛、香葉草醇、水芹烯、二烯丙基二硫醚、丙基烯丙基二硫醚、二烯丙基三硫醚之分析可藉由通常已知之分析法中適合於測定試樣之情況之方法來進行分析。
本發明之發泡性經口固形製劑中之成分(A)之含量為0.001質量%以上且0.11質量%以下。藉由使製劑以該特定量含有成分(A)，可提高舌、頜下腺唾液分泌量，且提高舌、頜下腺唾液之分泌之持續性。又，由於不會對口腔黏膜等產生危害性，故而可降低不快感。 關於發泡性經口固形製劑中之成分(A)之含量，就增加舌、頜下腺唾液分泌量之觀點、及提高舌、頜下腺唾液之分泌持續性之觀點而言，為0.001質量%以上，較佳為0.002質量%以上，更佳為0.005質量%以上，進而較佳為0.006質量%以上，進而更佳為0.008質量%以上，又，就降低黏膜之不快感之觀點而言，為0.11質量%以下，較佳為0.10質量%以下，更佳為0.07質量%以下，進而較佳為0.03質量%以下，進而較佳為0.025質量%以下。發泡性經口固形製劑中之成分(A)之含量為0.001～0.11質量%，較佳為0.002～0.10質量%，更佳為0.005～0.07質量%，進而較佳為0.006～0.03質量%，進而更佳為0.006～0.025質量%，尤佳為0.008～0.025質量%。
本發明之發泡性經口固形製劑含有碳酸鹽作為成分(B)。作為碳酸鹽，例如可列舉碳酸鈉、碳酸氫鈉、碳酸鉀、碳酸氫鉀、碳酸銨、倍半碳酸鈉等。該等可使用1種或將2種以上組合而使用。其中，就提高舌、頜下腺唾液分泌量之觀點而言，較佳為碳酸鈉、碳酸氫鈉、碳酸鉀，更佳為碳酸氫鈉。
本發明之發泡性經口固形製劑中之成分(B)之含量為7質量%以上且40質量%以下。藉由以該特定量含有成分(B)，可提高舌、頜下腺唾液之分泌，增加舌、頜下腺唾液分泌量。 關於發泡性經口固形製劑中之成分(B)之含量，就增加舌、頜下腺唾液分泌量之觀點、及提高舌、頜下腺唾液之分泌持續性之觀點而言，為7質量%以上，較佳為10質量%以上，更佳為15質量%以上，又，就降低黏膜之不快感之觀點而言，為40質量%以下，較佳為35質量%以下，更佳為30質量%以下。發泡性經口固形製劑中之成分(B)之含量為7～40質量%，較佳為10～35質量%，更佳為15～30質量%。 於本說明書中，成分(B)之含量為碳酸換算值。
本發明之發泡性經口固形製劑中之成分(B)之莫耳數(mmol/100 g)係指換算成成分(B)中之碳酸離子或碳酸氫離子時之莫耳數。 關於發泡性經口固形製劑中之成分(B)之含量，就增加舌、頜下腺唾液分泌量之觀點、及提高舌、頜下腺唾液之分泌持續性之觀點而言，較佳為80 mmol/100 g以上，更佳為115 mmol/100 g以上，進而較佳為175 mmol/100 g以上，又，就降低黏膜之不快感之觀點而言，較佳為480 mmol/100 g以下，更佳為420 mmol/100 g以下，進而較佳為360 mmol/100 g以下。發泡性經口固形製劑中之成分(B)之莫耳數(mmol/100 g)較佳為80～480 mmol/100 g，更佳為115～420 mmol/100 g，進而較佳為175～360 mmol/100 g。
關於本發明之發泡性經口固形製劑中成分(A)相對於成分(B)之含有質量比[(A)/(B)]，就增加舌、頜下腺唾液分泌量之觀點、提高舌、頜下腺唾液之分泌持續性之觀點、及降低黏膜之不快感之觀點而言，較佳為0.0001以上，更佳為0.0002以上，進而較佳為0.00025以上，又，就降低黏膜之不快感之觀點而言，較佳為0.0035以下，更佳為0.0015以下，進而較佳為0.001以下，進而更佳為0.0007以下。並且，成分(A)相對於成分(B)之含有質量比[(A)/(B)]較佳為0.0001～0.0035，更佳為0.0002～0.0015，進而較佳為0.0002～0.001，進而更佳為0.00025～0.0007。
本發明之發泡性經口固形製劑含有有機酸或其鹽作為成分(C)。有機酸或其鹽並無特別限制，較佳為選自羥基羧酸、二羧酸、抗壞血酸及該等之鹽中之1種或2種以上。 作為羥基羧酸，例如可列舉乳酸、檸檬酸、異檸檬酸、蘋果酸、酒石酸、葡萄糖酸、奎尼酸等。 作為二羧酸，例如可列舉草酸、丙二酸、琥珀酸、戊二酸、己二酸、富馬酸、馬來酸等。 抗壞血酸中包括作為立體異構物之L-抗壞血酸及異抗壞血酸。 作為鹽，較佳為鹼金屬鹽，進而較佳為選自鈉鹽及鉀鹽中之1種，進而較佳為鈉鹽。 其中，就增加舌、頜下腺唾液分泌量之觀點、提高舌、頜下腺唾液之分泌持續性之觀點、及降低黏膜之不快感之觀點而言，較佳為選自羥基羧酸、抗壞血酸及該等之鹽中之1種或2種以上，更佳為檸檬酸、酒石酸、L-抗壞血酸，就降低黏膜之不快感之觀點而言，進而較佳為檸檬酸。
本發明之發泡性經口固形製劑中之成分(C)之酸基之莫耳數(mmol/100 g)為50 mmol/100 g以上且600 mmol/100 g以下。藉由以成分(C)之酸基之莫耳數成為該特定量之方式含有成分(C)，可提高舌、頜下腺唾液之分泌，增加舌、頜下腺唾液分泌量。又，可緩和有機酸之刺激而降低黏膜之不快感。 關於發泡性經口固形製劑中之成分(C)之酸基之莫耳數(mmol/100 g)，就增加舌、頜下腺唾液分泌量之觀點、提高舌、頜下腺唾液之分泌持續性之觀點、及降低黏膜之不快感之觀點而言，為50 mmol/100 g以上，較佳為70 mmol/100 g以上，更佳為110 mmol/100 g以上，進而較佳為150 mmol/100 g以上，進而較佳為200 mmol/100 g以上，又，就同樣之觀點而言，為600 mmol/100 g以下，較佳為500 mmol/100 g以下，更佳為470 mmol/100 g以下，進而較佳為360 mmol/100 g以下，進而較佳為280 mmol/100 g以下。發泡性經口固形製劑中之成分(C)之酸基之莫耳數(mmol/100 g)為50～600 mmol/100 g，較佳為70～500 mmol/100 g，更佳為110～470 mmol/100 g，進而較佳為150～470 mmol/100 g，進而更佳為150～360 mmol/100 g，尤佳為200～280 mmol/100 g。 再者，於本發明中，將抗壞血酸作為具有1個酸基之有機酸而計算上述酸基之莫耳數。
關於本發明之發泡性經口固形製劑中之成分(C)之含量，就增加舌、頜下腺唾液分泌量之觀點、提高舌、頜下腺唾液之分泌持續性之觀點、及降低黏膜之不快感之觀點而言，較佳為5質量%以上，更佳為7質量%以上，進而較佳為10質量%以上，進而較佳為13質量%以上，又，就同樣之觀點而言，較佳為40質量%以下，更佳為30質量%以下，進而較佳為25質量%以下，進而較佳為18質量%以下。發泡性經口固形製劑中之成分(C)之含量較佳為5～40質量%，更佳為7～30質量%，進而較佳為10～25質量%，進而較佳為13～18質量%。 於本說明書中，成分(C)之含量為有機酸換算值。
本發明之發泡性經口固形製劑中成分(B)之莫耳數(mol)與成分(C)之酸基之莫耳數(mol)的比[(B)之莫耳數(mol)/(C)之酸基之莫耳數(mol)]為0.25以上且3.0以下。藉由將碳酸鹽之莫耳數與有機酸或其鹽之酸基之莫耳數設為該特定比，可降低黏膜之不快感。又，可提高舌、頜下腺唾液之分泌，增加舌、頜下腺唾液分泌量，且其持續性亦提高。 關於成分(B)之莫耳數(mol)與成分(C)之酸基之莫耳數(mol)的比[(B)之莫耳數(mol)/(C)之酸基之莫耳數(mol)]，就增加舌、頜下腺唾液分泌量之觀點、提高舌、頜下腺唾液之分泌持續性之觀點、及降低黏膜之不快感之觀點而言，為0.25以上，較佳為0.3以上，更佳為0.5以上，進而較佳為0.8以上，又，就同樣之觀點而言，為3.0以下，較佳為2.6以下，更佳為2.5以下，進而較佳為2以下，進而較佳為1.5以下。成分(B)之莫耳數(mol)與成分(C)之酸基之莫耳數(mol)的比[(B)之莫耳數(mol)/(C)之酸基之莫耳數(mol)]為0.25～3.0，較佳為0.3～2.6，更佳為0.3～2.5，進而較佳為0.5～2，進而較佳為0.5～1.5，進而更佳為0.8～1.5。
關於本發明之發泡性經口固形製劑中成分(B)相對於成分(C)之含有質量比[(B)/(C)]，就增加舌、頜下腺唾液分泌量之觀點、提高舌、頜下腺唾液之分泌持續性之觀點、及降低黏膜之不快感之觀點而言，較佳為0.35以上，更佳為0.4以上，進而較佳為0.65以上，進而更佳為1.0以上，又，就同樣之觀點而言，較佳為4.0以下，更佳為3.3以下，進而較佳為2.7以下，進而更佳為2.0以下。並且，本發明之發泡性經口固形製劑中成分(B)相對於成分(C)之含有質量比[(B)/(C)]較佳為0.3～4.0，更佳為0.4～3.3，進而較佳為0.65～2.7，進而更佳為1.0～2.0。
又，關於本發明之發泡性經口固形製劑中成分(B)及(C)之合計量相對於成分(A)之含有質量比[((B)＋(C))/(A)]，就降低黏膜之不快感之觀點、增加舌、頜下腺唾液分泌量之觀點、及提高頜下腺唾液之分泌之持續性之觀點而言，較佳為500以上，更佳為1,000以上，進而較佳為3,000以上，又，較佳為30,000以下，更佳為20,000以下，進而較佳為7,000以下。並且，本發明之發泡性經口固形製劑中成分(B)及(C)之合計量相對於成分(A)之含有質量比[((B)＋(C))/(A)]較佳為500～30,000，更佳為1,000～20,000，進而較佳為3,000～7,000。
本發明之發泡性經口固形製劑除上述成分以外，亦可於不損及本發明之效果之範圍內適當地調配甜味料、維生素、礦物質、表沒食子兒茶素沒食子酸酯、茶黃素或烏龍雙黃烷等茶兒茶素類、萃取物類、香料、著色料、防腐劑等。添加劑之含量可於不損及本發明之目的之範圍內適當地設定。
就降低黏膜之不快感之觀點而言，本發明之飲料用粉末食品中之成分(C)以外之酸味料之含量較佳為1質量%以下，更佳為0.5質量%以下，進而較佳為0.1質量%以下，進而更佳為實質上0質量%。
又，本發明之發泡性經口固形製劑視需要可含有容許之載體。例如可列舉：賦形劑(例如葡萄糖、半乳糖、果糖等單糖類；蔗糖、乳糖、麥芽糖、海藻糖、巴拉金糖等雙糖類；麥芽糖醇、木糖醇、赤藻糖醇、山梨糖醇、還原巴拉金糖等糖醇)；結合劑(例如羥丙基甲基纖維素、羥丙基纖維素、明膠、α化澱粉、聚乙烯吡咯啶酮、聚乙烯醇、支鏈澱粉、甲基纖維素、氫化油等)；崩解劑(例如羧甲基纖維素、羧甲基纖維素鈣、交聯羧甲基纖維素鈉、交聯聚維酮、玉米澱粉、低取代度羥丙基纖維素等)；潤滑劑(例如硬脂酸鈣、硬脂酸鎂、蔗糖脂肪酸酯、硬脂富馬酸鈉、滑石、二氧化矽等)；矯味劑(例如甜菊等)；寡醣、瓊脂、結晶纖維素、粉末纖維素、輕質矽酸酐、磷酸氫鈣、增量劑、界面活性劑、分散劑、緩衝劑、稀釋劑等載體。載體之含量可於不損及本發明之目的之範圍內適當地設定。
其中，就降低黏膜之不快感之觀點、增加舌、頜下腺唾液分泌量之觀點、及提高頜下腺唾液之分泌之持續性之觀點而言，本發明之發泡性經口固形製劑較佳為含有糖醇。糖醇可為酸酐、水合物之任一者。 關於發泡性經口固形製劑中之糖醇之含量，就降低黏膜之不快感之觀點而言，較佳為10質量%以上，更佳為20質量%以上，進而較佳為30質量%以上，又，就增加舌、頜下腺唾液分泌量之觀點、及提高頜下腺唾液之分泌之持續性之觀點而言，較佳為85質量%以下，更佳為80質量%以下。發泡性經口固形製劑中之糖醇之含量較佳為10～85質量%，更佳為20～85質量%，進而較佳為30～80質量%。 作為糖醇之定量法，可利用HPLC(High Performance Liquid Chromatography，高效液相層析法)。例如，可使用胺基系管柱並藉由示差折射率檢測法進行分析(食物纖維基礎與應用 監修：日本食物纖維學會 編纂：日本食物纖維學會編纂委員會 其他作者：青木誠一郎 出版社：第一出版股份有限公司 發售日：2008年10月)。
作為本發明中用以將發泡性經口錠劑封入之密封容器，較佳為空氣不透過性容器、尤其是二氧化碳不透過性容器，可使用各種塑膠與鋁等金屬之層壓包裝容器、或蒸鍍有鋁、二氧化矽等之包裝容器、以及利用金屬、玻璃等之容器。此處言及之二氧化碳不透過性係指二氧化碳透過度為50 cc/m2
・day・atm(ASTD-1434)以下之性質。藉由將使用此種素材之容器密封等而進行密閉，能夠以二氧化碳不洩露之方式進行密封。
本發明之發泡性經口固形製劑可依照常規方法進行製造，可採用適當之方法。例如，可將成分(A)、成分(B)及成分(C)、視需要之載體及/或添加劑以成分(A)及成分(B)之含量、成分(C)之酸基之莫耳數成為上述範圍內且成分(B)之莫耳數(mol)與成分(C)之酸基之莫耳數(mol)的比成為上述範圍內之方式進行混合而製造。各成分之混合順序並無特別限定，可以任意順序添加，亦可同時添加。作為混合方法，可採用攪拌、振盪等適當之方法，亦可使用混合裝置。混合裝置之混合方式可為容器旋轉型，亦可為容器固定型。作為容器旋轉型，例如可採用水平圓筒型、V型、雙錐型、立方型等。又，作為容器固定型，例如可採用帶型、螺旋型、圓錐形螺旋型、槳型、流動層型、飛利浦攪拌機等。 又，亦可藉由公知之造粒法製成造粒物。作為造粒方法，例如可列舉噴霧造粒、流動層造粒、壓縮造粒、滾動造粒、攪拌造粒、擠出造粒、粉末被覆造粒等。造粒條件可根據造粒方法適當地進行選擇。
於製成錠劑之情形時，可將成分(A)、成分(B)及成分(C)、視需要之載體及/或添加劑之混合物作為原料粉末直接壓縮而成形，亦可藉由上述造粒方法進行造粒後利用壓錠成形機將造粒物進行壓縮而成形。 於直接或將造粒物進行壓縮而成形而製造錠劑之情形時，作為壓錠成形機，可使用旋轉式壓錠機或單銃式壓錠機等通常使用之壓錠成形機。 關於壓錠時之壓縮成形壓力，就維持成形物之硬度之觀點而言，較佳為10～30 MPa左右。 又，錠劑硬度較佳為可耐受搬運或保存等之硬度，較佳為10 N～200 N左右。 錠劑之形狀可為圓形或橢圓形、長圓形、四邊形等具有面形之各種異形錠，就服用性之觀點而言，較佳為圓形。於為圓形錠之情形時，就服用性之觀點而言，直徑較佳為3～30 mm，更佳為10～20 mm。又，就簡便性及有效性之方面而言，錠劑較佳為每一製劑設為0.1～6 g、進而為0.3～3 g之重量。
由於本發明之發泡性經口固形製劑使唾液中抗病毒活性較高之舌、頜下腺唾液之分泌量增加，進而使其分泌持續，故而作為要求日常頻繁之預防應對之流行性感冒、感冒等之預防病毒感染用之製劑較有用。
就降低黏膜之不快感之觀點、增加舌、頜下腺唾液分泌量之觀點、及提高頜下腺唾液之分泌之持續性之觀點而言，本發明之發泡性經口固形製劑較佳為如下之發泡性經口固形製劑，其含有以下之成分(A)、(B)及(C)： (A)選自薑萃取物及辣椒萃取物中之1種以上 0.001質量%以上且0.11質量%以下 (B)碳酸鹽 7質量%以上且40質量%以下 (C)有機酸或其鹽，且 成分(C)之酸基之莫耳數為50 mmol/100 g以上且600 mmol/100 g以下，成分(B)之莫耳數(mol)與成分(C)之酸基之莫耳數(mol)的比[(B)鹽之莫耳數(mol)/(C)之酸基之莫耳數(mol)]為0.25以上且3.0以下，成分(B)及(C)之合計量相對於成分(A)之含有質量比[((B)＋(C))/(A)]為500以上且30,000以下。
就降低黏膜之不快感之觀點、增加舌、頜下腺唾液分泌量之觀點、及提高舌、頜下腺唾液之分泌之持續性之觀點而言，本發明之發泡性經口固形製劑較佳為如下之發泡性經口固形製劑，其含有以下之成分(A)、(B)及(C)： (A)選自薑萃取物及辣椒萃取物中之1種以上 0.001質量%以上且0.11質量%以下 (B)碳酸鹽 7質量%以上且40質量%以下 (C)有機酸或其鹽，且 成分(C)之酸基之莫耳數為50 mmol/100 g以上且600 mmol/100 g以下，成分(B)之莫耳數(mol)與成分(C)之酸基之莫耳數(mol)的比[(B)鹽之莫耳數(mol)/(C)之酸基之莫耳數(mol)]為0.25以上且3.0以下，成分(A)相對於成分(B)之含有質量比[(A)/(B)]為0.0001以上且0.0035以下，成分(B)及(C)之合計量相對於成分(A)之含有質量比[((B)＋(C))/(A)]為500以上且30,000以下。
就降低黏膜之不快感之觀點、增加舌、頜下腺唾液分泌量之觀點、及提高舌、頜下腺唾液之分泌之持續性之觀點而言，本發明之發泡性經口固形製劑較佳為如下之發泡性經口固形製劑，其含有以下之成分(A)、(B)及(C)： (A)薑萃取物 0.001質量%以上且0.11質量%以下 (B)碳酸鹽 7質量%以上且40質量%以下 (C)有機酸或其鹽，且 成分(C)之酸基之莫耳數為50 mmol/100 g以上且600 mmol/100 g以下，成分(B)之莫耳數(mol)與成分(C)之酸基之莫耳數(mol)的比[(B)鹽之莫耳數(mol)/(C)之酸基之莫耳數(mol)]為0.25以上且3.0以下，成分(A)相對於成分(B)之含有質量比[(A)/(B)]為0.0001以上且0.0035以下，成分(B)及(C)之合計量相對於成分(A)之含有質量比[((B)＋(C))/(A)]為500以上且30,000以下。
關於上述實施形態，本發明揭示以下之發泡性經口固形製劑。
＜1＞一種發泡性經口固形製劑，其含有以下之成分(A)、(B)及(C)： (A)香辛料萃取物 0.001質量%以上且0.11質量%以下 (B)碳酸鹽 7質量%以上且40質量%以下 (C)有機酸或其鹽，且 成分(C)之酸基之莫耳數為50 mmol/100 g以上且600 mmol/100 g以下，成分(B)之莫耳數(mol)與成分(C)之酸基之莫耳數(mol)的比[(B)鹽之莫耳數(mol)/(C)之酸基之莫耳數(mol)]為0.25以上且3.0以下。
＜2＞如＜1＞記載之發泡性經口固形製劑，其中成分(A)較佳為選自薑萃取物及辣椒萃取物中之1種或2種以上，更佳為薑萃取物。 ＜3＞如＜1＞或＜2＞記載之發泡性經口固形製劑，其中成分(A)之含量為0.001質量%以上，較佳為0.002質量%以上，更佳為0.005質量%以上，進而較佳為0.006質量%以上，進而更佳為0.008質量%以上，又，為0.11質量%以下，較佳為0.10質量%以下，更佳為0.07質量%以下，進而較佳為0.03質量%以下，進而較佳為0.025質量%以下，又，為0.001～0.11質量%，較佳為0.002～0.10質量%，更佳為0.005～0.07質量%，進而較佳為0.006～0.03質量%，進而更佳為0.006～0.025質量%，尤佳為0.008～0.025質量%。 ＜4＞如＜1＞至＜3＞中任一項記載之發泡性經口固形製劑，其中成分(B)較佳為選自碳酸鈉、碳酸氫鈉、碳酸鉀、碳酸氫鉀、碳酸鈣、碳酸鎂及倍半碳酸鈉中之1種或2種以上，更佳為選自碳酸鈉及碳酸氫鈉中之1種或2種，進而較佳為碳酸氫鈉。 ＜5＞如＜1＞至＜4＞中任一項記載之發泡性經口固形製劑，其中成分(B)之含量為7質量%以上，較佳為10質量%以上，更佳為15質量%以上，又，為40質量%以下，較佳為35質量%以下，更佳為30質量%以下，又，為7～40質量%，較佳為10～35質量%，更佳為15～30質量%。 ＜6＞如＜1＞至＜5＞中任一項記載之發泡性經口固形製劑，其中成分(B)之含量較佳為80 mmol/100 g以上，更佳為115 mmol/100 g以上，進而較佳為175 mmol/100 g以上，又，較佳為480 mmol/100 g以下，更佳為420 mmol/100 g以下，進而較佳為360 mmol/100 g以下，又，較佳為80～480 mmol/100 g，更佳為115～420 mmol/100 g，進而較佳為175～360 mmol/100 g。 ＜7＞如＜1＞至＜6＞中任一項記載之發泡性經口固形製劑，其中成分(A)相對於成分(B)之含有質量比[(A)/(B)]較佳為0.0001以上，更佳為0.0002以上，進而較佳為0.00025以上，又，較佳為0.0035以下，更佳為0.0015以下，進而較佳為0.001以下，進而更佳為0.0007以下，又，較佳為0.0001～0.0035，更佳為0.0002～0.0015，進而較佳為0.0002～0.001，進而更佳為0.00025～0.0007。 ＜8＞如＜1＞至＜7＞中任一項記載之發泡性經口固形製劑，其中成分(C)較佳為選自羥基羧酸、二羧酸、抗壞血酸及該等之鹽中之1種或2種以上，更佳為選自乳酸、檸檬酸、異檸檬酸、蘋果酸、酒石酸、葡萄糖酸、奎尼酸、草酸、丙二酸、琥珀酸、戊二酸、己二酸、富馬酸、馬來酸、L-抗壞血酸、異抗壞血酸及該等之鹽中之1種或2種以上，更佳為選自檸檬酸、蘋果酸、酒石酸、琥珀酸、富馬酸、L-抗壞血酸及該等之鹽中之1種或2種以上，進而較佳為選自檸檬酸、酒石酸、L-抗壞血酸及該等之鹽中之1種或2種以上，進而更佳為選自檸檬酸及該等之鹽中之1種或2種以上。 ＜9＞如＜1＞至＜8＞中任一項記載之發泡性經口固形製劑，其中成分(C)之酸基之莫耳數(mmol/100 g)為50 mmol/100 g以上，較佳為70 mmol/100 g以上，更佳為110 mmol/100 g以上，進而較佳為150 mmol/100 g以上，進而較佳為200 mmol/100 g以上，又，為600 mmol/100 g以下，較佳為500 mmol/100 g以下，更佳為470 mmol/100 g以下，進而較佳為360 mmol/100 g以下，進而較佳為280 mmol/100 g以下，又，為50～600 mmol/100 g，較佳為70～500 mmol/100 g，更佳為110～470 mmol/100 g，進而較佳為150～470 mmol/100 g，進而更佳為150～360 mmol/100 g，尤佳為200～280 mmol/100 g。 ＜10＞如＜1＞至＜9＞中任一項記載之發泡性經口固形製劑，其中成分(C)之含量較佳為5質量%以上，更佳為7質量%以上，進而較佳為10質量%以上，進而較佳為13質量%以上，又，較佳為40質量%以下，更佳為30質量%以下，進而較佳為25質量%以下，進而較佳為18質量%以下，又，較佳為5～40質量%，更佳為7～30質量%，進而較佳為10～25質量%，進而較佳為13～18質量%。 ＜11＞如＜1＞至＜10＞中任一項記載之發泡性經口固形製劑，其中成分(B)之莫耳數(mol)與成分(C)之酸基之莫耳數(mol)的比[(B)之莫耳數(mol)/(C)之酸基之莫耳數(mol)]為0.25以上，較佳為0.3以上，更佳為0.5以上，進而較佳為0.8以上，又，為3.0以下，較佳為2.6以下，更佳為2.5以下，進而較佳為2以下，進而較佳為1.5以下，又，為0.25～3.0，較佳為0.3～2.6，更佳為0.3～2.5，進而較佳為0.5～2，進而較佳為0.5～1.5，進而更佳為0.8～1.5。 ＜12＞如＜1＞至＜11＞中任一項記載之發泡性經口固形製劑，其中成分(B)相對於成分(C)之含有質量比[(B)/(C)]較佳為0.35以上，更佳為0.4以上，進而較佳為0.65以上，進而更佳為1.0以上，又，較佳為4.0以下，更佳為3.3以下，進而較佳為2.7以下，進而更佳為2.0以下，又，較佳為0.3～4.0，更佳為0.4～3.3，進而較佳為0.65～2.7，進而更佳為1.0～2.0。 ＜13＞如＜1＞至＜12＞中任一項記載之發泡性經口固形製劑，其中成分(B)及(C)之合計量相對於成分(A)之含有質量比[((B)＋(C))/(A)]較佳為500以上，更佳為1,000以上，進而較佳為3,000以上，又，較佳為30,000以下，更佳為20,000以下，進而較佳為7,000以下，又，較佳為500～30,000，更佳為1,000～20,000，進而較佳為3,000～7,000。 ＜14＞如＜1＞至＜13＞中任一項記載之發泡性經口固形製劑，其中成分(C)以外之酸味料之含量較佳為1質量%以下，更佳為0.5質量%以下，進而較佳為0.1質量%以下，進而更佳為實質上0質量%。 ＜15＞如＜1＞至＜14＞中任一項記載之發泡性經口固形製劑，其進而含有糖醇。 ＜16＞如＜15＞記載之發泡性經口固形製劑，其中糖醇之含量較佳為10質量%以上，更佳為20質量%以上，進而較佳為30質量%以上，又，較佳為85質量%以下，更佳為80質量%以下，又，較佳為10～85質量%，更佳為20～85質量%，進而較佳為30～80質量%。 ＜17＞如＜1＞至＜16＞中任一項記載之發泡性經口固形製劑，其被封入至較佳為空氣不透過性容器、更佳為二氧化碳不透過性容器中。 ＜18＞如＜1＞至＜17＞中任一項記載之發泡性經口固形製劑，其形態較佳為錠劑、膠囊劑、顆粒劑、散劑或口含劑，更佳為錠劑或口含劑，進而較佳為口含劑。 [實施例]
[6-薑酚、6-薑醇之分析] 6-薑酚、6-薑醇之含量係藉由高效液相層析法(HPLC)進行測定。將向試樣中添加水及甲醇並進行10分鐘超音波處理後進行定容所獲得者設為HPLC用分析試樣。 HPLC之分析條件如下所述。 ＜HPLC分析條件＞ 管柱：Inertsil ODS-2、
4.6 mm×250 mm、5 μm(GL Science(股)) 管柱溫度：40℃ 檢測器：UV(ultraviolet，紫外線)＝280 nm 流動相：水、乙腈、甲酸之混合液 流速：1.0 mL/min
[辣椒素之分析] 辣椒素之含量係藉由高效液相層析法(HPLC)進行測定。將向試樣中添加甲醇並進行10分鐘超音波處理後進行定容所獲得者設為HPLC用分析試樣。 HPLC之分析條件如下所述。 ＜HPLC操作條件＞ 管柱：Shim-pack FC-ODS4.6 mm×7.5 cm(SHIMADZU GLC(股)) 管柱溫度：50℃ 檢測器：螢光檢測器(激發波長：283 nm，測定波長：316 nm) 流動相：水、乙腈、乙酸之混合液 流速：1.0 mL/min
[碳酸鹽之分析] 發泡性經口固形製劑中之碳酸鹽之含量之分析方法如下所述。 採集發泡性經口固形製劑0.1～0.2 g，添加水10 mL及50%磷酸2 mL並栓緊。進行10分鐘超音波處理後，放置1小時而將頂隙氣體供於氣相層析儀而求出CO2
量，根據所產生之CO2
量算出。 ＜氣相層析儀操作條件＞ 機種：GC-14B、島津製作所(股) 檢測器：TCD(Thermal Conductivity Detector，熱導偵檢器) 管柱：Chromosorb101、80～100 mesh 玻璃管、3.2 mm×2 m 溫度：管柱50℃、注入口及檢測器100℃ 槽電流：75 mA 氣壓：氦氣(載體氣體)100 kPa 注入量：頂隙氣體0.2 mL
[有機酸之分析] 發泡性經口固形製劑中之有機酸之含量之分析方法如下所述。 採集發泡性經口固形製劑1 g，添加5%過氯酸20 mL，振盪10分鐘，藉此進行萃取。利用水將其定容為200 mL並進行10分鐘超音波處理。於過濾後供於高效液相層析儀(HPLC)。 ＜HPLC操作條件＞ 機種：LC-20AD、島津製作所(股) 檢測器：紫外可見吸光光度計SPD-20AV、島津製作所(股) 管柱：Shim-pack SCR-102H 300×80(長度×內徑(mm)) 島津製作所(股) 管柱溫度：40℃ 流動相：3 mmol/L之過氯酸 反應液：含有0.2 mmol/L溴瑞香草酚藍之15 mmol/L之磷酸氫二鈉溶液 流量：流動相1.0 mL/min、反應液1.4 mL/min 測定波長：445 nm
[原料] 薑萃取物：薑萃取物粉末E(池田糖化工業(股)，6-薑酚之含量：0.93質量%，6-薑醇：2.30質量%，6-薑酚＋6-薑醇：3.23質量%) 辣椒萃取物：辣椒素(富士膠片和光純藥工業(股)) 碳酸氫鈉：碳酸氫鈉(食品添加劑C)(Tosoh(股)) 檸檬酸：扶桑檸檬酸(酐)(扶桑化學工業(股)) 酒石酸：L-酒石酸(扶桑化學工業(股)) 抗壞血酸：L-抗壞血酸、Vitamin C TypeS(扶桑化學工業(股)) 麥芽糖醇：Amalty MR-50(三菱商事食品技術(股)) 粉末纖維素：KC Flock W400-G(NIPPON PAPER Chemicals(股)) 硬脂酸鈣：硬脂酸鈣(植物性)(太平化學產業(股)) 二氧化矽：Carplex FPS-500(DSL Japan)
實施例1～16及比較例1～14 以表1中所記載之調配組成將各成分進行混合。繼而，使用單銃式壓錠機(RIKEN製造)利用孔徑15 mm之環狀杵以18 MPa之壓錠壓力進行壓錠，獲得錠劑重量1 g/1錠、直徑15 mm之圓形錠劑。再者，於各組合物中，例如，於使用薑萃取物粉末E(池田糖化工業(股))製成錠劑之情形時，組合物中不可避免地含有糊精等賦形劑，但其等於表中未具體明示，包含於麥芽糖醇之含量中。 對所獲得之錠劑進行以下之評價。
[舌、頜下腺唾液分泌量] 對將上述各實施例及比較例中所獲得之錠劑於舌上靜置1分鐘時之舌、頜下腺唾液分泌量進行評價。評價基準設為如下，3名專業官能檢查員進行官能試驗，求出專業官能檢查員之評分之平均值，將小數點後第2位四捨五入而決定評價分數。再者，將服用時強烈確認到唾液分泌之實施例16評價為「5」，將略微確認到唾液分泌之比較例5評價為評價基準之「2」而以5個階段進行評價。評價基準
5：強烈確認到唾液分泌 4：確認到唾液分泌 3：稍微確認到唾液分泌 2：略微確認到唾液分泌 1：未確認到唾液分泌
[舌、頜下腺唾液分泌之持續性] 將上述各實施例及比較例中所獲得之錠劑於舌上靜置1分鐘後，將錠劑取出，對取出後10分鐘後之舌、頜下腺唾液分泌之持續性進行評價。評價基準設為如下，3名專業官能檢查員進行官能試驗，求出專業官能檢查員之評分之平均值，將小數點後第2位四捨五入而決定評價分數。再者，將服用時強烈確認到唾液分泌之實施例16評價為「5」，將略微確認到唾液分泌之比較例4評價為評價基準之「2」而以5個階段進行評價。評價基準
5：強烈確認到唾液分泌 4：確認到唾液分泌 3：稍微確認到唾液分泌 2：略微確認到唾液分泌 1：未確認到唾液分泌
[無黏膜之不快感] 對將上述各實施例及比較例中所獲得之錠劑於舌上靜置1分鐘時之黏膜之不快感進行評價。評價基準設為如下，3名專業官能檢查員進行官能試驗，求出專業官能檢查員之評分之平均值，將小數點後第2位四捨五入而決定評價分數。再者，將服用時完全感受不到刺激性味道所導致之不快感之實施例1評價為「5」，將強烈感受到刺激性味道所導致之不快感之比較例4評價為評價基準之「1」而以5個階段進行評價。評價基準
5：完全感受不到不快感 4：極少地感受到不快感 3：略微感受到不快感 2：感受到不快感 1：強烈感受到不快感 將結果示於表1-1及表1-2。
[表1-1]
| (質量%) | 實施例1 | 實施例2 | 實施例3 | 實施例4 | 實施例5 | 實施例6 | 實施例7 | 實施例8 | 實施例9 | 實施例10 | 實施例11 | 實施例12 | 實施例13 | 實施例14 | 實施例15 | 實施例16 |
| (A)薑萃取物1) | 0.002 | 0.002 | 0.002 | 0.002 | 0.006 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.03 | 0.03 | 0.03 | 0.10 |
| (B)碳酸氫鈉 | 8.50 | 10.00 | 20.00 | 30.00 | 20.00 | 10.00 | 10.00 | 20.00 | 20.00 | 20.00 | 25.00 | 30.00 | 10.00 | 20.00 | 30.00 | 30.00 |
| (C)檸檬酸 | 6.50 | 7.60 | 15.30 | 22.90 | 15.30 | 7.60 | 15.30 | 7.60 | 15.30 | 30.00 | 7.60 | 22.90 | 7.60 | 15.30 | 22.90 | 22.90 |
| 麥芽糖醇 | 77.00 | 74.40 | 56.70 | 39.10 | 56.69 | 74.39 | 66.69 | 64.39 | 56.69 | 41.99 | 59.39 | 39.09 | 74.37 | 56.67 | 39.07 | 39.00 |
| 粉末纖維素 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 |
| 硬脂酸鈣 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 |
| 二氧化矽 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| (合計) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 |
| (B)之莫耳數[mmol/100 g] | 101.18 | 119.03 | 238.07 | 357.10 | 238.07 | 119.03 | 119.03 | 238.07 | 238.07 | 238.07 | 297.58 | 357.10 | 119.03 | 238.07 | 357.10 | 357.10 |
| (C)之莫耳數[mmol/100 g] | 33.83 | 39.56 | 79.64 | 119.20 | 79.64 | 39.56 | 79.64 | 39.56 | 79.64 | 156.15 | 39.56 | 119.20 | 39.56 | 79.64 | 119.20 | 119.20 |
| (C)之酸基之莫耳數[mmol/100 g] | 101.50 | 118.68 | 238.91 | 357.59 | 238.91 | 118.68 | 238.91 | 118.68 | 238.91 | 468.46 | 118.68 | 357.59 | 118.68 | 238.91 | 357.59 | 357.59 |
| (B)之莫耳數(mol)/(C)之酸基之莫耳數(mol) | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.50 | 2.01 | 1.00 | 0.51 | 2.51 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| (B)/(C) | 1.31 | 1.32 | 1.31 | 1.31 | 1.31 | 1.32 | 0.65 | 2.63 | 1.31 | 0.67 | 3.29 | 1.31 | 1.32 | 1.31 | 1.31 | 1.31 |
| (B)＋(C) | 15.00 | 17.60 | 35.30 | 52.90 | 35.30 | 17.60 | 25.30 | 27.60 | 35.30 | 50.00 | 32.60 | 52.90 | 17.60 | 35.30 | 52.90 | 52.90 |
| (A)/(B) | 0.00024 | 0.00020 | 0.00010 | 0.00007 | 0.00030 | 0.00100 | 0.00100 | 0.00050 | 0.00050 | 0.00050 | 0.00040 | 0.00033 | 0.00300 | 0.00150 | 0.00100 | 0.00333 |
| [(B)＋(C)]/(A) | 7500.0 | 8800.0 | 17650.0 | 26450.0 | 5883.3 | 1760.0 | 2530.0 | 2760.0 | 3530.0 | 5000.0 | 3260.0 | 5290.0 | 586.7 | 1176.7 | 1763.3 | 529.0 |
| 舌、頜下腺唾液分泌量 | 3.7 | 3.7 | 4.3 | 4.7 | 4.7 | 3.7 | 4.3 | 4.0 | 4.7 | 4.0 | 4.0 | 5.0 | 4.0 | 4.7 | 5.0 | 5.0 |
| 舌、頜下腺唾液分泌之持續性 | 4.0 | 4.3 | 4.3 | 4.3 | 4.7 | 4.0 | 4.3 | 4.0 | 4.7 | 4.7 | 4.0 | 4.7 | 4.3 | 4.7 | 4.7 | 5.0 |
| 無黏膜之不快感 | 5.0 | 5.0 | 5.0 | 4.3 | 5.0 | 5.0 | 3.7 | 3.0 | 5.0 | 3.7 | 4.0 | 4.0 | 3.7 | 3.3 | 3.0 | 2.7 |
| 1)於表中之實施例中，薑萃取物為6-薑酚＋6-薑醇，數值表示6-薑酚＋6-薑醇合計量 |
[表1-2]
| (質量%) | 比較例1 | 比較例2 | 比較例3 | 比較例4 | 比較例5 | 比較例6 | 比較例7 | 比較例8 | 比較例9 | 比較例10 | 比較例11 | 比較例12 | 比較例13 | 比較例14 |
| (A)薑萃取物1) | 0.00 | 0.00 | 0.00 | 0.00 | 0.006 | 0.10 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.03 | 0.12 | 0.12 |
| (B)碳酸氫鈉 | 20.00 | 30.00 | 0.00 | 0.00 | 0.00 | 0.00 | 10.00 | 10.00 | 20.00 | 20.00 | 5.00 | 5.00 | 20.00 | 30.00 |
| (C)檸檬酸 | 15.30 | 22.90 | 7.60 | 15.30 | 0.00 | 0.00 | 2.00 | 40.00 | 2.00 | 40.00 | 3.80 | 3.80 | 15.30 | 22.90 |
| 麥芽糖醇 | 56.70 | 39.10 | 84.40 | 76.70 | 91.99 | 91.90 | 79.99 | 41.99 | 69.99 | 31.99 | 83.19 | 83.17 | 56.58 | 38.98 |
| 粉末纖維素 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 |
| 硬脂酸鈣 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 |
| 二氧化矽 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| (合計) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 |
| (B)之莫耳數[mmol/100 g] | 238.07 | 357.10 | 0.00 | 0.00 | 0.00 | 0.00 | 119.03 | 119.03 | 238.07 | 238.07 | 59.52 | 59.52 | 238.07 | 357.10 |
| (C)之莫耳數[mmol/100 g] | 79.64 | 119.20 | 39.56 | 79.64 | 0.00 | 0.00 | 10.41 | 208.20 | 10.41 | 208.20 | 19.78 | 19.78 | 79.64 | 119.20 |
| (C)之酸基之莫耳數[mmol/100 g] | 238.91 | 357.59 | 118.68 | 238.91 | 0.00 | 0.00 | 31.23 | 624.61 | 31.23 | 624.61 | 59.34 | 59.34 | 238.91 | 357.59 |
| (B)之莫耳數(mol)/(C)之酸基之莫耳數(mol) | 1.00 | 1.00 | - | - | - | - | 3.81 | 0.19 | 7.62 | 0.38 | 1.00 | 1.00 | 1.00 | 1.00 |
| (B)/(C) | 1.31 | 1.31 | - | - | - | - | 5.00 | 0.25 | 10.00 | 0.50 | 1.32 | 1.32 | 1.31 | 1.31 |
| (B)＋(C) | 35.30 | 52.90 | 7.60 | 15.30 | 0.00 | 0.00 | 12.00 | 50.00 | 22.00 | 60.00 | 8.80 | 8.80 | 35.30 | 52.90 |
| (A)/(B) | - | - | - | - | - | - | 0.00100 | 0.00100 | 0.00050 | 0.00050 | 0.00200 | 0.00600 | 0.00600 | 0.00400 |
| [(B)＋(C)]/(A) | - | - | - | - | - | - | 1200.0 | 5000.0 | 2200.0 | 6000.0 | 880.0 | 293.3 | 294.2 | 440.8 |
| 舌、頜下腺唾液分泌量 | 3.7 | 4.3 | 2.7 | 3.3 | 2.0 | 3.3 | 2.0 | 3.3 | 2.0 | 4.0 | 2.0 | 2.0 | 4.3 | 5.0 |
| 舌、頜下腺唾液分泌之持續性 | 1.7 | 2.0 | 2.0 | 2.0 | 3.3 | 4.0 | 3.7 | 3.7 | 3.7 | 3.7 | 3.7 | 3.7 | 4.7 | 5.0 |
| 無黏膜之不快感 | 4.7 | 3.7 | 1.3 | 1.0 | 3.7 | 1.7 | 3.3 | 1.7 | 2.7 | 1.7 | 4.3 | 3.3 | 1.3 | 1.3 |
| 1)於表中之實施例中，薑萃取物為6-薑酚＋6-薑醇，數值表示6-薑酚＋6-薑醇合計量 |
實施例17及18 以表2中所記載之調配組成將各成分均勻地混合，並藉由與實施例1相同之方法獲得錠劑。 藉由與實施例1相同之方法對所獲得之錠劑進行測定與官能評價。將其結果示於表2。
[表2]
| (質量%) | 實施例17 | 實施例18 | ||
| (A)薑萃取物1 ) | 0.01 | 0.01 | ||
| (B)碳酸氫鈉 | 20.00 | 20.00 | ||
| (C) | 酒石酸 | 18.00 | 0.00 | |
| 抗壞血酸 | 0.00 | 40.00 | ||
| 麥芽糖醇 | 53.99 | 31.99 | ||
| 粉末纖維素 | 5.00 | 5.00 | ||
| 硬脂酸鈣 | 2.00 | 2.00 | ||
| 二氧化矽 | 1.00 | 1.00 | ||
| (合計) | 100.00 | 100.00 | ||
| (B)之莫耳數[mmol/100 g] | 238.07 | 238.07 | ||
| (C)之莫耳數[mmol/100 g] | 119.93 | 227.12 | ||
| (C)之酸基之莫耳數[mmol/100 g] | 239.86 | 227.12 | ||
| (B)之莫耳數(mol)/(C)之酸基之莫耳數(mol) | 0.99 | 1.05 | ||
| (B)/(C) | 1.11 | 0.50 | ||
| (B)＋(C) | 38.00 | 60.00 | ||
| (A)/(B) | 0.00050 | 0.00050 | ||
| [(B)＋(C)]/(A) | 3800.0 | 6000.0 | ||
| 舌、頜下腺唾液分泌量 | 4.7 | 4.7 | ||
| 舌、頜下腺唾液分泌之持續性 | 4.7 | 4.7 | ||
| 無黏膜之不快感 | 4.0 | 3.3 | ||
| 1)於表中之實施例中，薑萃取物為6-薑酚＋6-薑醇，數值表示6-薑酚＋6-薑醇合計量。 |
實施例19～21 以表3中所記載之調配組成將各成分均勻地混合，並藉由與實施例1相同之方法獲得錠劑。 藉由與實施例1相同之方法對所獲得之錠劑進行測定與官能評價。將其結果示於表3。
[表3]
| (質量%) | 實施例19 | 實施例20 | 實施例21 |
| (A)辣椒萃取物2) | 0.01 | 0.002 | 0.10 |
| (B)碳酸氫鈉 | 20.00 | 20.00 | 20.00 |
| (C)檸檬酸 | 15.30 | 15.30 | 15.30 |
| 麥芽糖醇 | 56.69 | 56.70 | 56.60 |
| 粉末纖維素 | 5.00 | 5.00 | 5.00 |
| 硬脂酸鈣 | 2.00 | 2.00 | 2.00 |
| 二氧化矽 | 1.00 | 1.00 | 1.00 |
| (合計) | 100.00 | 100.00 | 100.00 |
| (B)之莫耳數[mmol/100 g] | 238.07 | 238.07 | 238.07 |
| (C)之莫耳數[mmol/100 g] | 79.64 | 79.64 | 79.64 |
| (C)之酸基之莫耳數[mmol/100 g] | 238.91 | 238.91 | 238.91 |
| (B)之莫耳數(mol)/(C)之酸基之莫耳數(mol) | 1.00 | 1.00 | 1.00 |
| (B)/(C) | 1.31 | 1.31 | 1.31 |
| (B)＋(C) | 35.30 | 35.30 | 35.30 |
| (A)/(B) | 0.00050 | 0.00010 | 0.00500 |
| [(B)＋(C)]/(A) | 3530.0 | 17650.0 | 353.0 |
| 舌、頜下腺唾液分泌量 | 4.7 | 4.3 | 4.7 |
| 舌、頜下腺唾液分泌之持續性 | 4.7 | 4.3 | 5 |
| 無黏膜之不快感 | 4.3 | 4.3 | 2.3 |
| 2)於表中之實施例中，辣椒萃取物為辣椒素，數值表示辣椒素量。 |
根據表1～3確認到：藉由將成分(A)及成分(B)之含量、成分(C)之酸基之莫耳數設為特定範圍內，且使成分(B)之莫耳數(mol)與成分(C)之酸基之莫耳數(mol)的比成為特定範圍內，可獲得提高舌、頜下腺唾液之分泌，進而使舌、頜下腺唾液之分泌持續之發泡性經口固形製劑。又，該發泡性經口固形製劑之黏膜之不快感亦較少。
可藉由常規方法分別製備下文所示之配方作為本發明之發泡性經口固形製劑。
[配方例1 發泡性經口固形製劑] 茶黃素 0.5質量% 薑萃取物(6-薑酚及6-薑醇) 0.01質量% 碳酸氫鈉 20.00質量% 檸檬酸 15.30質量% 麥芽糖醇 56.19質量% 粉末纖維素 5.00質量% 硬脂酸鈣 2.00質量% 二氧化矽 1.00質量% 共計 100質量% [配方例2 發泡性經口固形製劑] 茶黃素 1.0質量% 薑萃取物(6-薑酚及6-薑醇) 0.01質量% 碳酸氫鈉 20.00質量% 檸檬酸 15.30質量% 麥芽糖醇 55.69質量% 粉末纖維素 5.00質量% 硬脂酸鈣 2.00質量% 二氧化矽 1.00質量% 共計 100質量% [配方例3 發泡性經口固形製劑] 茶黃素 2.0質量% 薑萃取物(6-薑酚及6-薑醇) 0.01質量% 碳酸氫鈉 20.00質量% 檸檬酸 15.30質量% 麥芽糖醇 54.69質量% 粉末纖維素 5.00質量% 硬脂酸鈣 2.00質量% 二氧化矽 1.00質量% 共計 100質量%
Claims (5)
- 一種發泡性經口固形製劑，其含有以下之成分(A)、(B)及(C)： (A)香辛料萃取物 0.001質量%以上且0.11質量%以下 (B)碳酸鹽 7質量%以上且40質量%以下 (C)有機酸或其鹽，且 成分(C)之酸基之莫耳數為50 mmol/100 g以上且600 mmol/100 g以下，成分(B)之莫耳數(mol)與成分(C)之酸基之莫耳數(mol)的比[(B)之莫耳數(mol)/(C)之酸基之莫耳數(mol)]為0.25以上且3.0以下。
- 如請求項1之發泡性經口固形製劑，其中成分(A)為薑萃取物及/或辣椒萃取物。
- 如請求項1或2之發泡性經口固形製劑，其中成分(C)為選自羥基羧酸、抗壞血酸及該等之鹽中之1種或2種以上。
- 如請求項1或2之發泡性經口固形製劑，其中成分(B)及(C)之合計量相對於成分(A)之含有質量比[((B)＋(C))/(A)]為500以上且30,000以下。
- 如請求項1或2之發泡性經口固形製劑，其進而含有10質量%以上且85質量%以下之糖醇。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018-246295 | 2018-12-27 | ||
| JP2018246295 | 2018-12-27 | ||
| JP2019-102021 | 2019-05-31 | ||
| JP2019102021 | 2019-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202038920A true TW202038920A (zh) | 2020-11-01 |
Family
ID=71127720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW108147568A TW202038920A (zh) | 2018-12-27 | 2019-12-25 | 發泡性經口固形製劑 |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP2020195364A (zh) |
| KR (1) | KR20210095905A (zh) |
| CN (1) | CN113226046A (zh) |
| TW (1) | TW202038920A (zh) |
| WO (1) | WO2020138334A1 (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020147552A (ja) * | 2019-03-15 | 2020-09-17 | 花王株式会社 | 抗ウイルス活性向上剤 |
| JP7507015B2 (ja) | 2019-06-21 | 2024-06-27 | 三生医薬株式会社 | 唾液分泌促進用組成物及びその製造方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001097627A1 (fr) * | 2000-06-21 | 2001-12-27 | Kao Corporation | Agents therapeutiques pour la gorge |
| JP2002000184A (ja) | 2000-06-21 | 2002-01-08 | Kao Corp | のどケア用アメ |
| JP2003048838A (ja) * | 2001-08-03 | 2003-02-21 | Kao Corp | 喉ケア剤 |
| US6596313B2 (en) * | 2001-08-06 | 2003-07-22 | The Quigley Corporation | Nutritional supplement and methods of using it |
| US6592896B2 (en) * | 2001-08-06 | 2003-07-15 | The Quigley Corporation | Medicinal composition and method of using it |
| CN100431553C (zh) * | 2002-12-26 | 2008-11-12 | 株式会社山田养蜂场本社 | 改善咽下障碍用组合物 |
| WO2007046890A1 (en) * | 2005-10-14 | 2007-04-26 | Effrx, Inc. | Lozenge for treatment of dry mouth and related conditions |
| CN102292111A (zh) * | 2008-12-24 | 2011-12-21 | 好侍食品株式会社 | 复合物及其制造方法 |
| JP2011068642A (ja) | 2009-08-28 | 2011-04-07 | Arimento Kogyo Kk | 唾液分泌促進剤 |
| EP3111924B1 (en) * | 2011-05-16 | 2019-07-10 | Colgate-Palmolive Company | Oral care compositions |
| JP6032598B2 (ja) * | 2012-10-18 | 2016-11-30 | 国立大学法人高知大学 | 嚥下機能改善剤 |
-
2019
- 2019-12-25 TW TW108147568A patent/TW202038920A/zh unknown
- 2019-12-26 CN CN201980086373.6A patent/CN113226046A/zh active Pending
- 2019-12-26 KR KR1020217019510A patent/KR20210095905A/ko not_active Application Discontinuation
- 2019-12-26 WO PCT/JP2019/051234 patent/WO2020138334A1/ja active Application Filing
- 2019-12-26 JP JP2019236713A patent/JP2020195364A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN113226046A (zh) | 2021-08-06 |
| WO2020138334A1 (ja) | 2020-07-02 |
| JP2020195364A (ja) | 2020-12-10 |
| KR20210095905A (ko) | 2021-08-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW202038920A (zh) | 發泡性經口固形製劑 | |
| KR20150024782A (ko) | 경구 조성물 | |
| JP4347161B2 (ja) | ホップ抽出物含有組成物 | |
| EP2262534B1 (en) | Palatable solid composition comprising antacid and saliva stimulant | |
| US20200230185A1 (en) | Composition containing cannabinoids with improved bioavailability | |
| JP5917078B2 (ja) | 固形状組成物 | |
| JP2010265217A (ja) | 唾液分泌促進剤及び唾液分泌促進用組成物 | |
| KR20150145332A (ko) | 플라본계 화합물 또는 캠페리아 파비플로라 추출물을 함유하는 치주질환 개선 조성물 | |
| JP7463058B2 (ja) | Ａｃｅ阻害活性を有する組成物 | |
| JP2005082546A (ja) | α−グルコシダーゼ阻害剤 | |
| JP2005089374A (ja) | 血糖値上昇抑制機能性飲食品 | |
| JP2021024858A (ja) | 血圧降下用組成物 | |
| JP6881890B2 (ja) | カテキン類吸収促進剤 | |
| JP2014227366A (ja) | 圧縮成形製剤 | |
| WO2017068805A1 (ja) | 唾液分泌促進剤、これを含有する口腔用組成物及び飲料用組成物 | |
| KR101621502B1 (ko) | 생맥산을 함유하는 발포제의 제조방법 | |
| JP7253372B2 (ja) | 血圧降下用組成物 | |
| WO2016195089A1 (ja) | 唾液分泌促進剤、口腔乾燥抑制剤及び口腔内うるおい付与剤、及び組成物 | |
| JP7287587B1 (ja) | 固形組成物 | |
| JP7321743B2 (ja) | 固形状組成物 | |
| JP7262760B2 (ja) | シワ予防・改善用の医薬品、医薬部外品、化粧料又は飲食品組成物 | |
| JP7451124B2 (ja) | 内服組成物およびその吸湿抑制方法 | |
| JP4473338B1 (ja) | メントール含有食品 | |
| JP2022174474A (ja) | 固形組成物 | |
| TW202207912A (zh) | 密封容器裝之發泡性經口錠劑 |