TW201919654A - 用於抑制α-ENaC表現之RNAi試劑及使用方法 - Google Patents
用於抑制α-ENaC表現之RNAi試劑及使用方法 Download PDFInfo
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- TW201919654A TW201919654A TW107123550A TW107123550A TW201919654A TW 201919654 A TW201919654 A TW 201919654A TW 107123550 A TW107123550 A TW 107123550A TW 107123550 A TW107123550 A TW 107123550A TW 201919654 A TW201919654 A TW 201919654A
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Classifications
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US12065458B2 (en) | 2018-02-17 | 2024-08-20 | Arrowhead Pharmaceuticals, Inc. | Trialkyne linking agents and methods of use |
| CA3089276A1 (en) * | 2018-02-17 | 2019-08-22 | Arrowhead Pharmaceuticals, Inc. | Trialkyne linking agents and methods of use |
| TW202130809A (zh) * | 2019-10-29 | 2021-08-16 | 美商愛羅海德製藥公司 | 用於抑制β-ENaC表現之RNAi藥劑、其組合物及使用方法 |
| KR20240117104A (ko) | 2021-12-21 | 2024-07-31 | 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 | 핵산, 핵산을 포함하는 조성물 및 접합체, 이들의 제조 방법 및 용도 |
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| IL305158A (en) | 2016-11-01 | 2023-10-01 | Arrowhead Pharmaceuticals Inc | Ligands of alpha-V beta-6 integrin and their uses |
| CR20190572A (es) * | 2017-07-06 | 2020-05-23 | Arrowhead Pharmaceuticals Inc | AGENTES DE iARN PARA LA INHIBICIÓN DE LA EXPRESIÓN DE ALFA-ENaC Y MÉTODOS DE USO |
| JP7445594B2 (ja) * | 2017-11-01 | 2024-03-07 | アローヘッド ファーマシューティカルズ インコーポレイテッド | インテグリンリガンドおよびその使用 |
| CA3089276A1 (en) * | 2018-02-17 | 2019-08-22 | Arrowhead Pharmaceuticals, Inc. | Trialkyne linking agents and methods of use |
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2018
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- 2018-07-05 MX MX2019014800A patent/MX2019014800A/es unknown
- 2018-07-05 US US16/028,006 patent/US10590416B2/en active Active
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- 2018-07-05 JP JP2019572571A patent/JP2020526192A/ja not_active Withdrawn
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- 2018-07-05 TN TNP/2019/000308A patent/TN2019000308A1/en unknown
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2019
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2020
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2021
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2023
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| PE20200746A1 (es) | 2020-07-24 |
| JP2020526192A (ja) | 2020-08-31 |
| ZA202100643B (en) | 2023-03-29 |
| IL271843A (en) | 2020-02-27 |
| CN119662650A (zh) | 2025-03-21 |
| CA3061752A1 (en) | 2019-01-10 |
| CN110832077B (zh) | 2025-01-03 |
| US11214802B2 (en) | 2022-01-04 |
| EP3649240A4 (en) | 2021-07-07 |
| US20200299691A1 (en) | 2020-09-24 |
| ECSP20000655A (es) | 2020-05-29 |
| MX2019014800A (es) | 2020-02-10 |
| AU2018297262A1 (en) | 2020-02-27 |
| US10590416B2 (en) | 2020-03-17 |
| US20190010494A1 (en) | 2019-01-10 |
| JOP20190263A1 (ar) | 2019-11-12 |
| CL2020000019A1 (es) | 2020-06-12 |
| US20220090077A1 (en) | 2022-03-24 |
| BR112019023650A2 (pt) | 2020-06-02 |
| TN2019000308A1 (en) | 2021-05-07 |
| JP2023158192A (ja) | 2023-10-26 |
| KR20200024793A (ko) | 2020-03-09 |
| UY37800A (es) | 2019-01-02 |
| PH12019502660A1 (en) | 2020-06-08 |
| EP3649240A1 (en) | 2020-05-13 |
| CO2019014671A2 (es) | 2020-01-17 |
| CN110832077A (zh) | 2020-02-21 |
| CR20190572A (es) | 2020-05-23 |
| WO2019010274A1 (en) | 2019-01-10 |
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