CA3061752A1 - Rnai agents for inhibiting expression of alpha-enac and methods of use - Google Patents
Rnai agents for inhibiting expression of alpha-enac and methods of use Download PDFInfo
- Publication number
- CA3061752A1 CA3061752A1 CA3061752A CA3061752A CA3061752A1 CA 3061752 A1 CA3061752 A1 CA 3061752A1 CA 3061752 A CA3061752 A CA 3061752A CA 3061752 A CA3061752 A CA 3061752A CA 3061752 A1 CA3061752 A1 CA 3061752A1
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- Prior art keywords
- rnai agent
- alpha
- enac
- sense strand
- nucleotides
- Prior art date
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- C12N15/09—Recombinant DNA-technology
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N2310/00—Structure or type of the nucleic acid
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762529132P | 2017-07-06 | 2017-07-06 | |
| US62/529,132 | 2017-07-06 | ||
| US201862631683P | 2018-02-17 | 2018-02-17 | |
| US62/631,683 | 2018-02-17 | ||
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| TN2019000308A1 (en) * | 2017-07-06 | 2021-05-07 | Arrowhead Pharmaceuticals Inc | RNAi AGENTS FOR INHIBITING EXPRESSION OF ALPHA-ENaC AND METHODS OF USE |
| EP3752166A4 (en) * | 2018-02-17 | 2022-04-06 | Arrowhead Pharmaceuticals, Inc. | TRIALKYN CONNECTORS AND METHOD OF USE |
| US12065458B2 (en) | 2018-02-17 | 2024-08-20 | Arrowhead Pharmaceuticals, Inc. | Trialkyne linking agents and methods of use |
| TW202130809A (zh) * | 2019-10-29 | 2021-08-16 | 美商愛羅海德製藥公司 | 用於抑制β-ENaC表現之RNAi藥劑、其組合物及使用方法 |
| CA3242059A1 (en) | 2021-12-21 | 2023-06-29 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing nucleic acid, preparation method thereof and use thereof |
| EP4562147A1 (en) * | 2022-07-27 | 2025-06-04 | E-Therapeutics plc | Nucleic acid compounds |
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| WO2024255759A1 (zh) * | 2023-06-13 | 2024-12-19 | 上海拓界生物医药科技有限公司 | 靶向MMP7的siRNA、siRNA缀合物及其医药用途 |
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| AU2018297262A1 (en) | 2020-02-27 |
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| US11214802B2 (en) | 2022-01-04 |
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| WO2019010274A1 (en) | 2019-01-10 |
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| CO2019014671A2 (es) | 2020-01-17 |
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