JP2020526192A - アルファ−ＥＮａＣの発現を阻害するためのＲＮＡｉ剤、および使用方法 - Google Patents

アルファ−ＥＮａＣの発現を阻害するためのＲＮＡｉ剤、および使用方法 Download PDF

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JP2020526192A
JP2020526192A JP2019572571A JP2019572571A JP2020526192A JP 2020526192 A JP2020526192 A JP 2020526192A JP 2019572571 A JP2019572571 A JP 2019572571A JP 2019572571 A JP2019572571 A JP 2019572571A JP 2020526192 A JP2020526192 A JP 2020526192A
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rnai agent
alpha
enac
nucleotides
sense strand
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JP2020526192A5 (enExample
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ゼン リ，
ゼン リ，
ルイ ジュー，
ルイ ジュー，
タオ ペイ，
タオ ペイ，
アンソニー ニコラス，
アンソニー ニコラス，
エリック ダブリュー． ブッシュ，
エリック ダブリュー． ブッシュ，
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アローヘッド ファーマシューティカルズ インコーポレイテッド
アローヘッド ファーマシューティカルズ インコーポレイテッド
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2019572571A 2017-07-06 2018-07-05 アルファ−ＥＮａＣの発現を阻害するためのＲＮＡｉ剤、および使用方法 Withdrawn JP2020526192A (ja)

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JP2023146393A JP2023158192A (ja) 2017-07-06 2023-09-08 アルファ－ＥＮａＣの発現を阻害するためのＲＮＡｉ剤、および使用方法

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US201762529132P 2017-07-06 2017-07-06
US62/529,132 2017-07-06
US201862631683P 2018-02-17 2018-02-17
US62/631,683 2018-02-17
US201862679549P 2018-06-01 2018-06-01
US62/679,549 2018-06-01
PCT/US2018/040874 WO2019010274A1 (en) 2017-07-06 2018-07-05 RNAI AGENTS OF INHIBITION OF ALPHA-ENAC GENE EXPRESSION AND METHODS OF USE

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JP2023146393A Pending JP2023158192A (ja) 2017-07-06 2023-09-08 アルファ－ＥＮａＣの発現を阻害するためのＲＮＡｉ剤、および使用方法

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CN (2) CN119662650A (enExample)
AU (1) AU2018297262A1 (enExample)
BR (1) BR112019023650A2 (enExample)
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US12065458B2 (en) 2018-02-17 2024-08-20 Arrowhead Pharmaceuticals, Inc. Trialkyne linking agents and methods of use
CA3089276A1 (en) * 2018-02-17 2019-08-22 Arrowhead Pharmaceuticals, Inc. Trialkyne linking agents and methods of use
TW202130809A (zh) * 2019-10-29 2021-08-16 美商愛羅海德製藥公司 用於抑制β-ENaC表現之RNAi藥劑、其組合物及使用方法
KR20240117104A (ko) 2021-12-21 2024-07-31 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 핵산, 핵산을 포함하는 조성물 및 접합체, 이들의 제조 방법 및 용도
WO2024023254A1 (en) * 2022-07-27 2024-02-01 E-Therapeutics Plc Nucleic acid compounds
US20250368992A1 (en) * 2022-07-27 2025-12-04 E-Therapeutics Plc Nucleic acid compounds
WO2024255759A1 (zh) * 2023-06-13 2024-12-19 上海拓界生物医药科技有限公司 靶向MMP7的siRNA、siRNA缀合物及其医药用途

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