CN119662650A - 用于抑制α-ENaC表达的RNAi剂及使用方法 - Google Patents

用于抑制α-ENaC表达的RNAi剂及使用方法 Download PDF

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Publication number
CN119662650A
CN119662650A CN202411877733.3A CN202411877733A CN119662650A CN 119662650 A CN119662650 A CN 119662650A CN 202411877733 A CN202411877733 A CN 202411877733A CN 119662650 A CN119662650 A CN 119662650A
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Prior art keywords
enac
nucleotides
rnai agent
antisense strand
sense strand
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CN202411877733.3A
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Chinese (zh)
Inventor
李珍
朱锐
裴涛
A·尼古拉斯
E·W·布什
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Arrowhead Pharmaceuticals Inc
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Arrowhead Pharmaceuticals Inc
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Publication of CN119662650A publication Critical patent/CN119662650A/zh
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2320/00—Applications; Uses
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202411877733.3A 2017-07-06 2018-07-05 用于抑制α-ENaC表达的RNAi剂及使用方法 Pending CN119662650A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201762529132P 2017-07-06 2017-07-06
US62/529132 2017-07-06
US201862631683P 2018-02-17 2018-02-17
US62/631683 2018-02-17
US201862679549P 2018-06-01 2018-06-01
US62/679549 2018-06-01
PCT/US2018/040874 WO2019010274A1 (en) 2017-07-06 2018-07-05 RNAI AGENTS OF INHIBITION OF ALPHA-ENAC GENE EXPRESSION AND METHODS OF USE
CN201880045293.1A CN110832077B (zh) 2017-07-06 2018-07-05 用于抑制α-ENaC表达的RNAi剂及使用方法

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CN201880045293.1A Division CN110832077B (zh) 2017-07-06 2018-07-05 用于抑制α-ENaC表达的RNAi剂及使用方法

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Publication Number Publication Date
CN119662650A true CN119662650A (zh) 2025-03-21

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CN202411877733.3A Pending CN119662650A (zh) 2017-07-06 2018-07-05 用于抑制α-ENaC表达的RNAi剂及使用方法
CN201880045293.1A Active CN110832077B (zh) 2017-07-06 2018-07-05 用于抑制α-ENaC表达的RNAi剂及使用方法

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US (3) US10590416B2 (enExample)
EP (1) EP3649240A4 (enExample)
JP (2) JP2020526192A (enExample)
KR (1) KR20200024793A (enExample)
CN (2) CN119662650A (enExample)
AU (1) AU2018297262A1 (enExample)
BR (1) BR112019023650A2 (enExample)
CA (1) CA3061752A1 (enExample)
CL (1) CL2020000019A1 (enExample)
CO (1) CO2019014671A2 (enExample)
CR (1) CR20190572A (enExample)
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IL (1) IL271843A (enExample)
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TN (1) TN2019000308A1 (enExample)
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US12065458B2 (en) 2018-02-17 2024-08-20 Arrowhead Pharmaceuticals, Inc. Trialkyne linking agents and methods of use
TW202130809A (zh) * 2019-10-29 2021-08-16 美商愛羅海德製藥公司 用於抑制β-ENaC表現之RNAi藥劑、其組合物及使用方法
WO2023116607A1 (zh) 2021-12-21 2023-06-29 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
CA3259147A1 (en) * 2022-07-27 2024-02-01 E-Therapeutics Plc NUCLEIC ACID COMPOUNDS
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PE20200746A1 (es) 2020-07-24
US11214802B2 (en) 2022-01-04
TW201919654A (zh) 2019-06-01
JOP20190263A1 (ar) 2019-11-12
ECSP20000655A (es) 2020-05-29
WO2019010274A1 (en) 2019-01-10
EP3649240A1 (en) 2020-05-13
CA3061752A1 (en) 2019-01-10
CL2020000019A1 (es) 2020-06-12
KR20200024793A (ko) 2020-03-09
AU2018297262A1 (en) 2020-02-27
JP2020526192A (ja) 2020-08-31
IL271843A (en) 2020-02-27
CR20190572A (es) 2020-05-23
PH12019502660A1 (en) 2020-06-08
ZA202100643B (en) 2023-03-29
US20190010494A1 (en) 2019-01-10
CO2019014671A2 (es) 2020-01-17
MX2019014800A (es) 2020-02-10
TN2019000308A1 (en) 2021-05-07
US20200299691A1 (en) 2020-09-24
CN110832077A (zh) 2020-02-21
CN110832077B (zh) 2025-01-03
BR112019023650A2 (pt) 2020-06-02
UY37800A (es) 2019-01-02
US10590416B2 (en) 2020-03-17
EP3649240A4 (en) 2021-07-07
JP2023158192A (ja) 2023-10-26
US20220090077A1 (en) 2022-03-24

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