EP1478655A4 - METHODS AND MATERIALS FOR MODULATING ENaC-BETA - Google Patents

METHODS AND MATERIALS FOR MODULATING ENaC-BETA

Info

Publication number
EP1478655A4
EP1478655A4 EP02799996A EP02799996A EP1478655A4 EP 1478655 A4 EP1478655 A4 EP 1478655A4 EP 02799996 A EP02799996 A EP 02799996A EP 02799996 A EP02799996 A EP 02799996A EP 1478655 A4 EP1478655 A4 EP 1478655A4
Authority
EP
European Patent Office
Prior art keywords
beta
materials
methods
enac
modulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02799996A
Other languages
German (de)
French (fr)
Other versions
EP1478655A2 (en
Inventor
Samuel J Shuster
Ulf N G Arvidsson
Laura S Stone
Hong-Yan Zhang
Lucy Vulchanova Hart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALGOS THERAPEUTICS Inc
Original Assignee
ALGOS THERAPEUTICS Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALGOS THERAPEUTICS Inc filed Critical ALGOS THERAPEUTICS Inc
Publication of EP1478655A2 publication Critical patent/EP1478655A2/en
Publication of EP1478655A4 publication Critical patent/EP1478655A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP02799996A 2001-12-31 2002-12-31 METHODS AND MATERIALS FOR MODULATING ENaC-BETA Withdrawn EP1478655A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34606901P 2001-12-31 2001-12-31
US346069P 2001-12-31
PCT/US2002/041850 WO2003057847A2 (en) 2001-12-31 2002-12-31 METHODS AND MATERIALS FOR MODULATING ENaC-BETA

Publications (2)

Publication Number Publication Date
EP1478655A2 EP1478655A2 (en) 2004-11-24
EP1478655A4 true EP1478655A4 (en) 2006-05-10

Family

ID=23357796

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02799996A Withdrawn EP1478655A4 (en) 2001-12-31 2002-12-31 METHODS AND MATERIALS FOR MODULATING ENaC-BETA

Country Status (3)

Country Link
EP (1) EP1478655A4 (en)
AU (1) AU2002364612A1 (en)
WO (1) WO2003057847A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2376400A1 (en) 1999-06-08 2000-12-14 University Of Iowa Research Foundation Compounds and methods to enhance raav transduction
AR066984A1 (en) 2007-06-15 2009-09-23 Novartis Ag INHIBITION OF THE EXPRESSION OF THE ALFA SUBUNITY OF THE SODIUM EPITELIAL CHANNEL (ENAC) THROUGH ARNI (INTERFERENCE RNA)
EA034363B1 (en) 2010-04-23 2020-01-30 Эрроухед Фармасьютикалс, Инк. PHARMACEUTICAL COMPOSITION FOR INHIBITING BETA-ENaC GENE EXPRESSION AND USE THEREOF
WO2013155406A1 (en) * 2012-04-12 2013-10-17 The Chinese University Of Hong Kong Contragestion and treating inflammation by modulating sodium channel activity in the epithelium
WO2017139381A1 (en) 2016-02-08 2017-08-17 University Of Iowa Research Foundation Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
EA201892006A1 (en) 2016-03-07 2019-04-30 Юниверсити Оф Айова Рисерч Фаундейшн AAV-MEDIATED EXPRESSION USING THE SYNTHETIC PROMOTER AND ENCHANSER
US10590416B2 (en) 2017-07-06 2020-03-17 Arrowhead Pharmaceuticals, Inc. RNAi agents for inhibiting expression of alpha-ENaC and methods of use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998040516A1 (en) * 1997-03-11 1998-09-17 Yale University Method to diagnose and treat pathological conditions resulting from deficient ion transport such as pseudohypoaldosteronism type-1
US20030077773A1 (en) * 2000-12-06 2003-04-24 Brandon Rhonda C. Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
DATABASE NCBI 11 June 1993 (1993-06-11), XP002370531, Database accession no. L15695 *
DATABASE NCBI 26 July 2000 (2000-07-26), XP002370524, Database accession no. AJ270360 *
DATABASE NCBI 28 September 1999 (1999-09-28), XP002370529, Database accession no. 1QMS_A *
DATABASE NCBI 3 October 1995 (1995-10-03), XP002370525, Database accession no. 1HAP_D *
DATABASE NCBI 5 June 1997 (1997-06-05), XP002370532, Database accession no. Y13518 *
DATABASE NCBI 6 March 2000 (2000-03-06), XP002370527, Database accession no. AJ132117 *
DATABASE NCBI 7 May 1993 (1993-05-07), XP002370528, Database accession no. S85712 *
DATABASE NCBI 7 May 1993 (1993-05-07), XP002370530, Database accession no. S81274 *
DATABASE NCBI 7 May 1996 (1996-05-07), XP002370526, Database accession no. X87698 *
JAIN LUCKY ET AL: "Antisense oligonucleotides against the alpha-subunit of ENaC decrease lung epithelial cation-channel activity", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 276, no. 6 PART 1, June 1999 (1999-06-01), pages L1046 - L1051, XP002370512, ISSN: 0002-9513 *
JAIN LUCKY ET AL: "Expression of highly selective sodium channels in alveolar type II cells is determined by culture conditions", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 280, no. 4 Part 1, April 2001 (2001-04-01), pages L646 - L658, XP002370510, ISSN: 0002-9513 *
MANO I ET AL: "DEG/ENAC CHANNELS A TOUCHY SUPERFAMILY THAT WATCHES ITS SALT", BIOESSAYS, CAMBRIDGE, GB, vol. 21, no. 7, July 1999 (1999-07-01), pages 568 - 578, XP008034073, ISSN: 0265-9247 *
ZUCCHI ILEANA ET AL: "Genetic dissection of dome formation in a mammary cell line: Identification of two genes with opposing action", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 96, no. 24, 23 November 1999 (1999-11-23), pages 13766 - 13770, XP002370511, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2003057847A3 (en) 2003-12-11
WO2003057847A2 (en) 2003-07-17
WO2003057847A8 (en) 2004-01-15
AU2002364612A1 (en) 2003-07-24
EP1478655A2 (en) 2004-11-24
AU2002364612A8 (en) 2003-07-24

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