EP1478655A4 - VERFAHREN UND MATERIALIEN ZUR MODULIERUNG VON ENaC-BETA - Google Patents

VERFAHREN UND MATERIALIEN ZUR MODULIERUNG VON ENaC-BETA

Info

Publication number
EP1478655A4
EP1478655A4 EP02799996A EP02799996A EP1478655A4 EP 1478655 A4 EP1478655 A4 EP 1478655A4 EP 02799996 A EP02799996 A EP 02799996A EP 02799996 A EP02799996 A EP 02799996A EP 1478655 A4 EP1478655 A4 EP 1478655A4
Authority
EP
European Patent Office
Prior art keywords
beta
materials
methods
enac
modulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02799996A
Other languages
English (en)
French (fr)
Other versions
EP1478655A2 (de
Inventor
Samuel J Shuster
Ulf N G Arvidsson
Laura S Stone
Hong-Yan Zhang
Lucy Vulchanova Hart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALGOS THERAPEUTICS Inc
Original Assignee
ALGOS THERAPEUTICS Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALGOS THERAPEUTICS Inc filed Critical ALGOS THERAPEUTICS Inc
Publication of EP1478655A2 publication Critical patent/EP1478655A2/de
Publication of EP1478655A4 publication Critical patent/EP1478655A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP02799996A 2001-12-31 2002-12-31 VERFAHREN UND MATERIALIEN ZUR MODULIERUNG VON ENaC-BETA Withdrawn EP1478655A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34606901P 2001-12-31 2001-12-31
US346069P 2001-12-31
PCT/US2002/041850 WO2003057847A2 (en) 2001-12-31 2002-12-31 METHODS AND MATERIALS FOR MODULATING ENaC-BETA

Publications (2)

Publication Number Publication Date
EP1478655A2 EP1478655A2 (de) 2004-11-24
EP1478655A4 true EP1478655A4 (de) 2006-05-10

Family

ID=23357796

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02799996A Withdrawn EP1478655A4 (de) 2001-12-31 2002-12-31 VERFAHREN UND MATERIALIEN ZUR MODULIERUNG VON ENaC-BETA

Country Status (3)

Country Link
EP (1) EP1478655A4 (de)
AU (1) AU2002364612A1 (de)
WO (1) WO2003057847A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1190249A2 (de) 1999-06-08 2002-03-27 University Of Iowa Research Foundation Verbindungen und methoden zur erhöhung von raav-transduktion
AR066984A1 (es) 2007-06-15 2009-09-23 Novartis Ag Inhibicion de la expresion de la subunidad alfa del canal epitelial de sodio (enac) por medio de arni (arn de interferencia)
CN102985544A (zh) 2010-04-23 2013-03-20 诺瓦提斯公司 治疗β-ENaC-相关疾病的有机组合物
WO2013155406A1 (en) * 2012-04-12 2013-10-17 The Chinese University Of Hong Kong Contragestion and treating inflammation by modulating sodium channel activity in the epithelium
US11702672B2 (en) 2016-02-08 2023-07-18 University Of Iowa Research Foundation Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
CA3016985C (en) 2016-03-07 2023-07-04 University Of Iowa Research Foundation Aav-mediated expression using a synthetic promoter and enhancer
KR20200024793A (ko) 2017-07-06 2020-03-09 애로우헤드 파마슈티컬스 인코포레이티드 알파-ENaC의 발현을 억제하기 위한 RNAi 작용제 및 사용 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0975798A1 (de) * 1997-03-11 2000-02-02 Yale University Verfahren zur diagnose und behandlung von pathalogischen zustaenden in zusammenhang mit ionentransportdefizienzen so als pseudohypoaldostereonismus typ i
US20030077773A1 (en) * 2000-12-06 2003-04-24 Brandon Rhonda C. Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
DATABASE NCBI 11 June 1993 (1993-06-11), XP002370531, Database accession no. L15695 *
DATABASE NCBI 26 July 2000 (2000-07-26), XP002370524, Database accession no. AJ270360 *
DATABASE NCBI 28 September 1999 (1999-09-28), XP002370529, Database accession no. 1QMS_A *
DATABASE NCBI 3 October 1995 (1995-10-03), XP002370525, Database accession no. 1HAP_D *
DATABASE NCBI 5 June 1997 (1997-06-05), XP002370532, Database accession no. Y13518 *
DATABASE NCBI 6 March 2000 (2000-03-06), XP002370527, Database accession no. AJ132117 *
DATABASE NCBI 7 May 1993 (1993-05-07), XP002370528, Database accession no. S85712 *
DATABASE NCBI 7 May 1993 (1993-05-07), XP002370530, Database accession no. S81274 *
DATABASE NCBI 7 May 1996 (1996-05-07), XP002370526, Database accession no. X87698 *
JAIN LUCKY ET AL: "Antisense oligonucleotides against the alpha-subunit of ENaC decrease lung epithelial cation-channel activity", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 276, no. 6 PART 1, June 1999 (1999-06-01), pages L1046 - L1051, XP002370512, ISSN: 0002-9513 *
JAIN LUCKY ET AL: "Expression of highly selective sodium channels in alveolar type II cells is determined by culture conditions", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 280, no. 4 Part 1, April 2001 (2001-04-01), pages L646 - L658, XP002370510, ISSN: 0002-9513 *
MANO I ET AL: "DEG/ENAC CHANNELS A TOUCHY SUPERFAMILY THAT WATCHES ITS SALT", BIOESSAYS, CAMBRIDGE, GB, vol. 21, no. 7, July 1999 (1999-07-01), pages 568 - 578, XP008034073, ISSN: 0265-9247 *
ZUCCHI ILEANA ET AL: "Genetic dissection of dome formation in a mammary cell line: Identification of two genes with opposing action", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 96, no. 24, 23 November 1999 (1999-11-23), pages 13766 - 13770, XP002370511, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2003057847A3 (en) 2003-12-11
WO2003057847A2 (en) 2003-07-17
EP1478655A2 (de) 2004-11-24
WO2003057847A8 (en) 2004-01-15
AU2002364612A1 (en) 2003-07-24
AU2002364612A8 (en) 2003-07-24

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