TW201613558A - Novel vaccine compositions for porcine epidemic diarrhea virus and porcine deltacoronavirus - Google Patents

Novel vaccine compositions for porcine epidemic diarrhea virus and porcine deltacoronavirus

Info

Publication number
TW201613558A
TW201613558A TW104122566A TW104122566A TW201613558A TW 201613558 A TW201613558 A TW 201613558A TW 104122566 A TW104122566 A TW 104122566A TW 104122566 A TW104122566 A TW 104122566A TW 201613558 A TW201613558 A TW 201613558A
Authority
TW
Taiwan
Prior art keywords
porcine
diarrhea virus
epidemic diarrhea
deltacoronavirus
pedv
Prior art date
Application number
TW104122566A
Other languages
English (en)
Inventor
Jacqueline Gayle Marx
John Morgan Hardham
Paul Joseph Dominowski
Gabrielson Vicki Jon Rapp
Sanuy Monica Balasch
Sumsi Marta Cabana
Dilme Laia Plaja
Hostench Alicia Urniza
Galindo Oscar Romero
Original Assignee
Zoetis Services Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis Services Llc filed Critical Zoetis Services Llc
Publication of TW201613558A publication Critical patent/TW201613558A/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20061—Methods of inactivation or attenuation
    • C12N2770/20063—Methods of inactivation or attenuation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20071—Demonstrated in vivo effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW104122566A 2014-07-11 2015-07-13 Novel vaccine compositions for porcine epidemic diarrhea virus and porcine deltacoronavirus TW201613558A (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201462023302P 2014-07-11 2014-07-11
US201462037403P 2014-08-14 2014-08-14
US201462046256P 2014-09-05 2014-09-05
US201462093657P 2014-12-18 2014-12-18
US201562102712P 2015-01-13 2015-01-13
US201562115806P 2015-02-13 2015-02-13
US201562121193P 2015-02-26 2015-02-26
US201562143412P 2015-04-06 2015-04-06

Publications (1)

Publication Number Publication Date
TW201613558A true TW201613558A (en) 2016-04-16

Family

ID=53783917

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104122566A TW201613558A (en) 2014-07-11 2015-07-13 Novel vaccine compositions for porcine epidemic diarrhea virus and porcine deltacoronavirus

Country Status (14)

Country Link
US (2) US10251950B2 (zh)
EP (2) EP3954385A1 (zh)
CA (2) CA3161295A1 (zh)
DK (1) DK3166634T3 (zh)
ES (1) ES2899204T3 (zh)
HR (1) HRP20211451T1 (zh)
HU (1) HUE056025T2 (zh)
LT (1) LT3166634T (zh)
PL (1) PL3166634T3 (zh)
PT (1) PT3166634T (zh)
RS (1) RS62414B1 (zh)
SI (1) SI3166634T1 (zh)
TW (1) TW201613558A (zh)
WO (1) WO2016007576A2 (zh)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107875381A (zh) * 2017-11-07 2018-04-06 陕西诺威利华生物科技有限公司 猪流行性腹泻、猪δ冠状病毒二联灭活疫苗以及其制备方法
CN110545841A (zh) * 2017-01-30 2019-12-06 勃林格殷格翰动物保健美国有限公司 猪冠状病毒疫苗
TWI703983B (zh) * 2019-09-25 2020-09-11 台灣糖業股份有限公司 豬流行性下痢病毒ts分離株及其用途
US11413347B2 (en) 2019-09-02 2022-08-16 Reber Genetics Co., Ltd. Vaccine composition and method of preventing porcine epidemic diarrhea virus infection in swine

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10034934B2 (en) 2014-03-11 2018-07-31 Regents Of The University Of Minnesota Porcine epidemic diarrhea virus vaccines and methods of use thereof
WO2016007576A2 (en) * 2014-07-11 2016-01-14 Zoetis Services Llc Novel vaccine compositions for porcine epidemic diarrhea virus and porcine deltacoronavirus
JP6824177B2 (ja) * 2015-02-27 2021-02-03 アイオア・ステート・ユニバーシティー・リサーチ・ファンデーション・インコーポレーテッドＩｏｗａ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ Ｉｎｃｏｒｐｏｒａｔｅｄ 豚流行性下痢ウイルス株及びそれから得られる免疫原性組成物
TW201731525A (zh) * 2015-11-25 2017-09-16 薩斯喀徹溫大學 治療、預防及診斷豬流行性下痢病毒感染之方法
WO2017123201A1 (en) * 2016-01-11 2017-07-20 Zoetis Services Llc Novel cross protective vaccine compositions for porcine epidemic diarrhea virus
CN105861744A (zh) * 2016-03-24 2016-08-17 天津出入境检验检疫局动植物与食品检测中心 用于快速等温检测猪德尔塔冠状病毒的引物组和方法
CN105861756A (zh) * 2016-06-16 2016-08-17 天津市畜牧兽医研究所 一种用于检测猪德尔塔冠状病毒的引物及应用
JP6253210B1 (ja) * 2016-08-17 2017-12-27 一般財団法人日本生物科学研究所 豚流行性下痢の予防又は治療方法、ワクチン、及びワクチンキット
CN107815440A (zh) * 2016-09-14 2018-03-20 华中农业大学 猪德尔塔冠状病毒株的分离、灭活疫苗的制备与应用
CN106518989B (zh) * 2016-11-16 2020-12-11 江苏省农业科学院 用于检测猪Delta冠状病毒抗体的多肽、制备方法及其应用
CN107899007B (zh) * 2017-11-06 2018-12-28 陕西诺威利华生物科技有限公司 猪流行性腹泻、猪传染性胃肠炎和猪δ冠状病毒的三联灭活疫苗及其制备方法
CN107899008B (zh) * 2017-11-08 2019-05-10 陕西诺威利华生物科技有限公司 一种猪流行性腹泻、猪传染性胃肠炎、猪丁型冠状病毒病三联亚单位疫苗
CN109796531B (zh) * 2017-11-15 2022-03-11 中国农业科学院上海兽医研究所 猪Delta冠状病毒N蛋白单克隆抗体及其抗原表位和应用
CN108315490B (zh) * 2018-04-20 2022-03-11 咸阳职业技术学院 猪急性腹泻综合征冠状病毒与德尔塔冠状病毒rt-pcr诊断试剂盒及其检测方法
CN113194989B (zh) 2018-12-20 2024-01-30 英特维特国际股份有限公司 初免-强化免疫接种方案
CN110144332B (zh) * 2019-05-13 2020-12-08 中国农业科学院兰州兽医研究所 一株猪德尔塔冠状病毒毒株及其应用
CN110960675B (zh) * 2019-12-17 2024-02-06 天康生物制药有限公司 仔猪腹泻防控用肚脐贴片疫苗及其制备方法
CN112662821A (zh) * 2021-01-30 2021-04-16 福建傲农生物科技集团股份有限公司 一种猪流行性腹泻病毒m基因的荧光探针引物组合、试剂盒及应用
CN114790448B (zh) * 2022-03-21 2023-03-31 华中农业大学 一株猪δ冠状病毒强毒株及其在疫苗制备中的应用
CN116253798B (zh) * 2022-12-15 2023-10-27 华中农业大学 一株针对猪δ冠状病毒S1蛋白构象表位的中和性单克隆抗体
CN116875562B (zh) * 2023-07-14 2024-06-14 河南农业大学 一株猪δ冠状病毒传代致弱毒株及其应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084269A (en) 1986-11-06 1992-01-28 Kullenberg Fred W Adjuvant for dose treatment with antigens
MX9301736A (es) * 1992-03-30 1994-01-31 Smithkline Beecham Corp Vacuna de bacterina-toxoide de pasteurella haemolytica tipo a-1.
TW579372B (en) * 1998-07-29 2004-03-11 Sumitomo Chemical Co Process for producing alumina sintered body
AU769539B2 (en) 1999-01-29 2004-01-29 Zoetis Services Llc Adjuvants for use in vaccines
US6974577B2 (en) * 2001-02-04 2005-12-13 Novartris Ag Inactivated bovine scours vaccines, processes and method of preventing bovine scours
WO2004087204A2 (en) * 2003-04-04 2004-10-14 Pfizer Products Inc. Microfluidized oil-in-water emulsions and vaccine compositions
KR100502008B1 (ko) 2003-04-29 2005-07-18 녹십자수의약품(주) 약독화된 돼지 유행성설사병 바이러스, 그를 포함하는면역원성 조성물 및 상기 바이러스를 검출하는 방법
KR100962179B1 (ko) * 2008-03-20 2010-06-10 주식회사한국야쿠르트 돼지 유행성 설사병 바이러스 감염을 억제하는 신규락토바실러스 루테리 에이취와이 25101 및 이를 함유하는사료첨가제
KR101484469B1 (ko) * 2010-10-26 2015-01-21 주식회사 중앙백신연구소 돼지 써코바이러스 관련 질환을 예방하기 위한 ｐｃｖ-2의 전체 바이러스를 포함하는 혼합백신
CN109675026A (zh) 2013-09-19 2019-04-26 硕腾服务有限责任公司 油基佐剂
JP6395855B2 (ja) * 2014-04-03 2018-09-26 ベーリンガー インゲルハイム フェトメディカ インコーポレイテッド ブタ流行性下痢ウイルスワクチン
WO2015179412A1 (en) 2014-05-19 2015-11-26 Merial, Inc. Recombinant spike protein subunit based vaccine for porcine epidemic diarrhea virus (pedv)
WO2016007576A2 (en) * 2014-07-11 2016-01-14 Zoetis Services Llc Novel vaccine compositions for porcine epidemic diarrhea virus and porcine deltacoronavirus
WO2016022028A1 (en) 2014-08-08 2016-02-11 Universiteit Utrecht Holding B.V. Mutant porcine epizootic diarrhea virus for use in a vaccine
CN104383528B (zh) * 2014-10-24 2016-08-24 江苏省农业科学院 猪流行性腹泻灭活疫苗及其制备方法

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110545841A (zh) * 2017-01-30 2019-12-06 勃林格殷格翰动物保健美国有限公司 猪冠状病毒疫苗
CN107875381A (zh) * 2017-11-07 2018-04-06 陕西诺威利华生物科技有限公司 猪流行性腹泻、猪δ冠状病毒二联灭活疫苗以及其制备方法
CN110314228A (zh) * 2017-11-07 2019-10-11 陕西诺威利华生物科技有限公司 猪流行性腹泻、猪δ冠状病毒二联灭活疫苗以及其制备方法
CN110314228B (zh) * 2017-11-07 2022-10-28 陕西诺威利华生物科技有限公司 猪流行性腹泻、猪δ冠状病毒二联灭活疫苗以及其制备方法
US11413347B2 (en) 2019-09-02 2022-08-16 Reber Genetics Co., Ltd. Vaccine composition and method of preventing porcine epidemic diarrhea virus infection in swine
TWI785373B (zh) * 2019-09-02 2022-12-01 瑞寶基因股份有限公司 預防豬中豬流行性下痢病毒感染的疫苗組合物及方法
TWI703983B (zh) * 2019-09-25 2020-09-11 台灣糖業股份有限公司 豬流行性下痢病毒ts分離株及其用途

Also Published As

Publication number Publication date
WO2016007576A3 (en) 2016-03-03
CA2954632C (en) 2022-08-30
HUE056025T2 (hu) 2022-01-28
US20170202951A1 (en) 2017-07-20
PT3166634T (pt) 2021-09-29
RS62414B1 (sr) 2021-10-29
CA2954632A1 (en) 2016-01-14
DK3166634T3 (da) 2021-09-27
CA3161295A1 (en) 2016-01-14
SI3166634T1 (sl) 2021-11-30
PL3166634T3 (pl) 2021-12-27
WO2016007576A2 (en) 2016-01-14
US20190216919A1 (en) 2019-07-18
EP3166634A2 (en) 2017-05-17
LT3166634T (lt) 2021-11-10
US10251950B2 (en) 2019-04-09
EP3166634B1 (en) 2021-08-18
WO2016007576A8 (en) 2016-12-22
ES2899204T3 (es) 2022-03-10
EP3954385A1 (en) 2022-02-16
HRP20211451T1 (hr) 2021-12-24
US10953088B2 (en) 2021-03-23

Similar Documents

Publication Publication Date Title
TW201613558A (en) Novel vaccine compositions for porcine epidemic diarrhea virus and porcine deltacoronavirus
EA201691993A1 (ru) Вакцина к вирусу эпидемической диареи свиней
EA201790294A1 (ru) Средства на основе флагеллина и применения, включающие эффективную вакцинацию
EA201391515A1 (ru) Инактивированная вакцина вируса денге
PH12017501370A1 (en) Bivalent swine influenza virus vaccine
EA201991041A1 (ru) Вакцина против свиного парвовируса и вируса свиного репродуктивного и респираторного синдрома и способы ее получения
MX2017016896A (es) Vacunas inactivadas contra la influenza canina, metodos para elaborarlas y sus usos.
EA201990010A1 (ru) Вакцина против вируса инфекционного бронхита
CU24580B1 (es) Vectores atenuados de influenza para la prevención y/o tratamiento de enfermedades infecciosas y para el tratamiento de enfermedades oncológicas
PH12015501378A1 (en) Porcine parvovirus 5a, methods of use and vaccine
MY179251A (en) Methods and compositions for recombinant dengue viruses for vaccine and diagnostic development
NZ731659A (en) Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus
PH12018501750A1 (en) Porcine reproductive and respiratory syndrome vaccine virus
MX363149B (es) Vacunas de nucleoproteina de la influenza.
PH12015501721A1 (en) Porcine parvovirus 5b, methods of use and vaccine
BR112018074910A2 (pt) composição imunológica, e, método de indução de uma resposta imunológica contra o vírus da influenza equina em um sujeito
PH12017501795B1 (en) Pestivirus vaccines for congenital tremors
EA201892003A1 (ru) Лечение атопического дерматита собак
MX2019007924A (es) Vacunas contra la influenza.
EA202090236A1 (ru) Иммуногенные композиции senecavirus a и способы с ними
WO2018175580A3 (en) Development of an alternative modified live influenza b virus vaccine
PH12017502378A1 (en) Inactivated canine influenza vaccines and methods of making and uses thereof
MX2020008927A (es) Vacuna contra la influenza atenuada viva multivalente para la prevencion y el control del virus de la influenza equina (eiv) en caballos.
EA202190351A1 (ru) Композиция, входящая в состав вакцины против гриппа
MX2020006327A (es) Deteccion de vacunas vivas modificadas contra el virus de la gripe porcina.