TW201321414A - 抗-HtrA1抗體及其使用方法 - Google Patents

抗-HtrA1抗體及其使用方法 Download PDF

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Publication number
TW201321414A
TW201321414A TW101137846A TW101137846A TW201321414A TW 201321414 A TW201321414 A TW 201321414A TW 101137846 A TW101137846 A TW 101137846A TW 101137846 A TW101137846 A TW 101137846A TW 201321414 A TW201321414 A TW 201321414A
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TW
Taiwan
Prior art keywords
seq
antibody
hvr
amino acid
acid sequence
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TW101137846A
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English (en)
Chinese (zh)
Inventor
Yan Wu
Menno Van Lookeren-Campagne
Daniel Kirchhofer
Michael Terry Lipari
Kenneth J Katschke
Paul M Moran
Scott Stawicki
Wei-Ching Liang
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Genentech Inc
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Publication of TW201321414A publication Critical patent/TW201321414A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
TW101137846A 2011-10-14 2012-10-12 抗-HtrA1抗體及其使用方法 TW201321414A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161547649P 2011-10-14 2011-10-14

Publications (1)

Publication Number Publication Date
TW201321414A true TW201321414A (zh) 2013-06-01

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Family Applications (1)

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TW101137846A TW201321414A (zh) 2011-10-14 2012-10-12 抗-HtrA1抗體及其使用方法

Country Status (33)

Country Link
US (3) US9738727B2 (https=)
EP (2) EP2766393B1 (https=)
JP (2) JP6532678B2 (https=)
KR (2) KR102102862B1 (https=)
CN (2) CN108373506A (https=)
AR (1) AR088322A1 (https=)
AU (2) AU2012322618A1 (https=)
BR (1) BR112014008862A2 (https=)
CA (1) CA2850032C (https=)
CL (1) CL2014000888A1 (https=)
CO (1) CO7020870A2 (https=)
CR (1) CR20140212A (https=)
DK (1) DK2766393T3 (https=)
EA (1) EA201490778A1 (https=)
ES (1) ES2687951T3 (https=)
HK (1) HK1255608A1 (https=)
HR (1) HRP20181457T1 (https=)
HU (1) HUE039133T2 (https=)
IL (1) IL232055B (https=)
LT (1) LT2766393T (https=)
MA (1) MA35712B1 (https=)
MX (2) MX390891B (https=)
PE (1) PE20141562A1 (https=)
PH (1) PH12014500841B1 (https=)
PL (1) PL2766393T3 (https=)
PT (1) PT2766393T (https=)
RS (1) RS57645B1 (https=)
SG (1) SG11201401477XA (https=)
SI (1) SI2766393T1 (https=)
TR (1) TR201811270T4 (https=)
TW (1) TW201321414A (https=)
WO (1) WO2013055998A1 (https=)
ZA (1) ZA201402172B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI747850B (zh) * 2015-10-30 2021-12-01 美商建南德克公司 抗HtrA1抗體及其使用方法
TWI774717B (zh) * 2016-12-22 2022-08-21 日商第一三共股份有限公司 老年性黃斑部變性症治療用肽及其製造方法
TWI906202B (zh) * 2018-06-21 2025-12-01 日商第一三共股份有限公司 視網膜色素變性治療用胜肽之用途

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AU2015253042A1 (en) 2014-05-01 2016-10-20 Genentech, Inc. Anti-factor D antibody variants and uses thereof
CR20170240A (es) 2014-11-10 2018-04-03 Genentech Inc Anticuerpos anti-interleucina-33 y sus usos
AU2016344133A1 (en) 2015-10-30 2018-05-17 Genentech, Inc. Anti-Factor D antibody formulations
US10407510B2 (en) 2015-10-30 2019-09-10 Genentech, Inc. Anti-factor D antibodies and conjugates
EP3368090A1 (en) 2015-10-30 2018-09-05 H. Hoffnabb-La Roche Ag Anti-factor d antibody variant conjugates and uses thereof
US10526315B2 (en) 2016-06-21 2020-01-07 Orion Ophthalmology LLC Carbocyclic prolinamide derivatives
PL3472149T3 (pl) 2016-06-21 2024-02-12 Orion Ophthalmology LLC Heterocykliczne pochodne prolinamidu
JP2018096930A (ja) * 2016-12-16 2018-06-21 公益財団法人ヒューマンサイエンス振興財団 加齢黄斑変性の診断マーカー、診断キット、診断補助方法、及び、発症リスク判定方法
US20200103419A1 (en) 2017-03-27 2020-04-02 The Schepens Eye Research Institute, Inc. Blood biomarkers and diagnostic methods for small vessel diseases
US11453718B2 (en) 2017-03-27 2022-09-27 The Schepens Eye Research Institute, Inc. NOTCH3 agonist compositions and methods for treating small vessel diseases
WO2019121838A1 (en) * 2017-12-21 2019-06-27 F. Hoffmann-La Roche Ag Companion diagnostic for htra1 rna antagonists
WO2020102680A1 (en) * 2018-11-16 2020-05-22 Gemini Therapeutics Inc. Antibody-based therapeutics for targeting htra1 and methods of use
WO2020109343A1 (en) 2018-11-29 2020-06-04 F. Hoffmann-La Roche Ag Combination therapy for treatment of macular degeneration
AU2019417720A1 (en) * 2018-12-24 2021-07-08 Visterra, Inc. Methods for identifying epitopes and paratopes
CA3136119A1 (en) * 2019-04-10 2020-10-15 University Of Utah Research Foundation Htra1 modulation for treatment of amd
PE20230252A1 (es) 2020-03-13 2023-02-07 Genentech Inc Anticuerpos anti-interleucina-33 y sus usos de estos
WO2022031680A1 (en) * 2020-08-04 2022-02-10 Exelixis, Inc. Cd47 binding agents and uses thereof
US20220251241A1 (en) * 2021-02-08 2022-08-11 Ngm Biopharmaceuticals, Inc. Htra1-binding agents and methods of use thereof

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