TW201144282A - Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds - Google Patents

Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds Download PDF

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Publication number
TW201144282A
TW201144282A TW099142648A TW99142648A TW201144282A TW 201144282 A TW201144282 A TW 201144282A TW 099142648 A TW099142648 A TW 099142648A TW 99142648 A TW99142648 A TW 99142648A TW 201144282 A TW201144282 A TW 201144282A
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TW
Taiwan
Prior art keywords
formula
solvent
compound
metal catalyst
hydrogen
Prior art date
Application number
TW099142648A
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English (en)
Chinese (zh)
Inventor
Hossein Razavi
Jonathan T Reeves
Sonia Rodriguez
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of TW201144282A publication Critical patent/TW201144282A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW099142648A 2009-12-08 2010-12-07 Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds TW201144282A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26753809P 2009-12-08 2009-12-08

Publications (1)

Publication Number Publication Date
TW201144282A true TW201144282A (en) 2011-12-16

Family

ID=43416915

Family Applications (1)

Application Number Title Priority Date Filing Date
TW099142648A TW201144282A (en) 2009-12-08 2010-12-07 Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds

Country Status (17)

Country Link
US (1) US20110137042A1 (cg-RX-API-DMAC10.html)
EP (1) EP2509952A1 (cg-RX-API-DMAC10.html)
JP (1) JP2013512954A (cg-RX-API-DMAC10.html)
KR (1) KR20120101667A (cg-RX-API-DMAC10.html)
CN (1) CN102596908A (cg-RX-API-DMAC10.html)
AR (1) AR079324A1 (cg-RX-API-DMAC10.html)
AU (1) AU2010328480A1 (cg-RX-API-DMAC10.html)
BR (1) BR112012013582A2 (cg-RX-API-DMAC10.html)
CA (1) CA2782384A1 (cg-RX-API-DMAC10.html)
CL (1) CL2012001300A1 (cg-RX-API-DMAC10.html)
EA (1) EA201200820A1 (cg-RX-API-DMAC10.html)
IL (1) IL219274A0 (cg-RX-API-DMAC10.html)
IN (1) IN2012DN05081A (cg-RX-API-DMAC10.html)
MX (1) MX2012006524A (cg-RX-API-DMAC10.html)
PH (1) PH12012501153A1 (cg-RX-API-DMAC10.html)
TW (1) TW201144282A (cg-RX-API-DMAC10.html)
WO (1) WO2011071730A1 (cg-RX-API-DMAC10.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2722923C (en) 2008-04-29 2016-08-02 Boehringer Ingelheim International Gmbh Indazole compounds as ccr1 receptor antagonists
JP5411927B2 (ja) * 2008-05-06 2014-02-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１アンタゴニストとしてのピラゾール化合物
BRPI0919844A2 (pt) 2008-09-26 2019-09-24 Boehringer Ingelheim Int compostos de azaindazol como antagonistas do receptor ccr1
HRP20140213T1 (hr) 2009-10-21 2014-04-11 Boehringer Ingelheim International Gmbh Spojevi indazola i pirazolopiridina kao antagonisti ccr1-receptora
JP5542214B2 (ja) 2009-10-27 2014-07-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体アンタゴニストとしての複素環化合物
JP5793182B2 (ja) 2010-04-30 2015-10-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体アンタゴニストとしてのアザインダゾールアミド化合物
WO2012087782A1 (en) 2010-12-23 2012-06-28 Boehringer Ingelheim International Gmbh Pyrazolopiperidine compounds as ccr1 receptor antagonists

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BRPI0919844A2 (pt) * 2008-09-26 2019-09-24 Boehringer Ingelheim Int compostos de azaindazol como antagonistas do receptor ccr1

Also Published As

Publication number Publication date
BR112012013582A2 (pt) 2016-07-05
EP2509952A1 (en) 2012-10-17
CL2012001300A1 (es) 2012-09-07
WO2011071730A1 (en) 2011-06-16
CN102596908A (zh) 2012-07-18
CA2782384A1 (en) 2011-06-16
AU2010328480A1 (en) 2012-05-17
MX2012006524A (es) 2012-07-17
AR079324A1 (es) 2012-01-18
JP2013512954A (ja) 2013-04-18
IL219274A0 (en) 2012-06-28
IN2012DN05081A (cg-RX-API-DMAC10.html) 2015-10-09
US20110137042A1 (en) 2011-06-09
KR20120101667A (ko) 2012-09-14
EA201200820A1 (ru) 2013-01-30
PH12012501153A1 (en) 2012-10-22

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