AR079324A1 - Proceso para la sintesis de compuestos intermedios de utilidad para preparar compuestos sustituidos de indazol y azaindazol - Google Patents

Proceso para la sintesis de compuestos intermedios de utilidad para preparar compuestos sustituidos de indazol y azaindazol

Info

Publication number
AR079324A1
AR079324A1 ARP100104528A ARP100104528A AR079324A1 AR 079324 A1 AR079324 A1 AR 079324A1 AR P100104528 A ARP100104528 A AR P100104528A AR P100104528 A ARP100104528 A AR P100104528A AR 079324 A1 AR079324 A1 AR 079324A1
Authority
AR
Argentina
Prior art keywords
compounds
compound
formula
azaindazol
indazol
Prior art date
Application number
ARP100104528A
Other languages
English (en)
Inventor
Jonathan T Reeves
Hossein Razavi
Sonia Rodriguez
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR079324A1 publication Critical patent/AR079324A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

Los compuestos son de utilidad como compuestos intermedios para preparar compuestos sustituidos con indazol y azaindazol. Reivindicacion 1: Un proceso de preparacion de un compuesto de la formula (1) en forma de una sal ionica, caracterizado porque comprende: i) hidrogenar un compuesto de la formula (2) usando un catalizador metálico con hidrogeno, durante 2-20 horas a 0-100sC, y ii) filtrar el catalizador seguido de tratamiento con una solucion ácida o gas, en donde la reaccion se lleva a cabo en un disolvente seleccionado de un disolvente de alcohol, disolventes de éster, ácidos acuosos, éteres y tolueno u otros disolventes hidrocarbonados aromáticos, para proporcionar un compuesto de la formula (1) en donde R es hidrogeno o alquilo C1-10.
ARP100104528A 2009-12-08 2010-12-07 Proceso para la sintesis de compuestos intermedios de utilidad para preparar compuestos sustituidos de indazol y azaindazol AR079324A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26753809P 2009-12-08 2009-12-08

Publications (1)

Publication Number Publication Date
AR079324A1 true AR079324A1 (es) 2012-01-18

Family

ID=43416915

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100104528A AR079324A1 (es) 2009-12-08 2010-12-07 Proceso para la sintesis de compuestos intermedios de utilidad para preparar compuestos sustituidos de indazol y azaindazol

Country Status (16)

Country Link
US (1) US20110137042A1 (es)
EP (1) EP2509952A1 (es)
JP (1) JP2013512954A (es)
KR (1) KR20120101667A (es)
CN (1) CN102596908A (es)
AR (1) AR079324A1 (es)
AU (1) AU2010328480A1 (es)
BR (1) BR112012013582A2 (es)
CA (1) CA2782384A1 (es)
CL (1) CL2012001300A1 (es)
EA (1) EA201200820A1 (es)
IL (1) IL219274A0 (es)
IN (1) IN2012DN05081A (es)
MX (1) MX2012006524A (es)
TW (1) TW201144282A (es)
WO (1) WO2011071730A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009134666A1 (en) 2008-04-29 2009-11-05 Boehringer Ingelheim International Gmbh Indazole compounds as ccr1 receptor antagonists
WO2009137338A1 (en) * 2008-05-06 2009-11-12 Boehringer Ingelheim International Gmbh Pyrazole compounds as ccr1 antagonists
NZ591115A (en) 2008-09-26 2012-10-26 Boehringer Ingelheim Int Azaindazole compounds as ccr1 receptor antagonists
AU2010308277A1 (en) 2009-10-21 2012-04-26 Boehringer Ingelheim International Gmbh Indazole and pyrazolopyridine compounds as CCR1 receptor antagonists
JP5542214B2 (ja) 2009-10-27 2014-07-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体アンタゴニストとしての複素環化合物
WO2011137109A1 (en) 2010-04-30 2011-11-03 Boehringer Ingelheim International Gmbh Azaindazole amide compounds as ccr1 receptor antagonists
JP5684406B2 (ja) 2010-12-23 2015-03-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体アンタゴニストとしてのピラゾロピペリジン化合物

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Also Published As

Publication number Publication date
TW201144282A (en) 2011-12-16
BR112012013582A2 (pt) 2016-07-05
JP2013512954A (ja) 2013-04-18
EA201200820A1 (ru) 2013-01-30
CA2782384A1 (en) 2011-06-16
MX2012006524A (es) 2012-07-17
IN2012DN05081A (es) 2015-10-09
CN102596908A (zh) 2012-07-18
WO2011071730A1 (en) 2011-06-16
IL219274A0 (en) 2012-06-28
US20110137042A1 (en) 2011-06-09
EP2509952A1 (en) 2012-10-17
KR20120101667A (ko) 2012-09-14
AU2010328480A1 (en) 2012-05-17
CL2012001300A1 (es) 2012-09-07

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