TW201120034A - Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts - Google Patents
Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts Download PDFInfo
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- TW201120034A TW201120034A TW099133406A TW99133406A TW201120034A TW 201120034 A TW201120034 A TW 201120034A TW 099133406 A TW099133406 A TW 099133406A TW 99133406 A TW99133406 A TW 99133406A TW 201120034 A TW201120034 A TW 201120034A
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- NWRUDSBAGUHOPD-UHFFFAOYSA-N 2-[5-(phenoxymethyl)-2-piperidin-1-yl-6-(tetrazol-1-yl)pyrimidin-4-yl]-1,3-thiazole Chemical class N=1C=CSC=1C=1N=C(N2CCCCC2)N=C(N2N=NN=C2)C=1COC1=CC=CC=C1 NWRUDSBAGUHOPD-UHFFFAOYSA-N 0.000 title 1
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- -1 pyridinium-pyridylpyrimidine Chemical compound 0.000 claims description 13
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Classifications
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
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| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| AU2008279447A1 (en) | 2007-07-19 | 2009-01-29 | Metabolex, Inc. | N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the RUP3 or GPR119 receptor for the treatment of diabetes and metabolic disorders |
| PL2280704T3 (pl) * | 2008-03-31 | 2015-10-30 | Cymabay Therapeutics Inc | Związki oksymetylenoarylowe i ich zastosowania |
| US20110160222A1 (en) * | 2008-11-26 | 2011-06-30 | Metabolex, Inc. | Modulators of glucose homeostasis for the treatment of diabetes and metabolic disorders |
| EP2483281B1 (en) * | 2009-10-01 | 2014-06-04 | Cymabay Therapeutics, Inc. | Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts |
| US20110313160A1 (en) * | 2010-06-04 | 2011-12-22 | Metabolex, Inc. | Preparation of 5-ethyl-2--pyrimidine |
| BR112012032248A2 (pt) * | 2010-06-23 | 2016-09-13 | Metabolex Inc | composições de 5-etil-2-{4-[-4(-4-tetrazol-1-il-fenoximetil)-tiazol-2-il]-piperidin-1-il}-pirimidina |
| KR101913619B1 (ko) | 2011-06-09 | 2018-12-28 | 리젠 파마슈티컬스 소시에떼 아노님 | Gpr-119의 조절제로서의 신규한 화합물 |
| CN103910710B (zh) * | 2012-12-29 | 2017-06-16 | 乳源东阳光药业有限公司 | 阿格列汀新晶型及其制备方法 |
| US20190008864A1 (en) * | 2014-01-23 | 2019-01-10 | Pharmedix.Co., Ltd. | Pharmaceutical composition containing gpr119 ligand as effective ingredient for preventing or treating non-alcoholic steatohepatitis |
| WO2018026890A1 (en) | 2016-08-03 | 2018-02-08 | Cymabay Therapeutics | Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions |
| US11634442B2 (en) * | 2017-07-18 | 2023-04-25 | Basf Se | Methods for the purification of L-glufosinate |
| MX2022010548A (es) | 2020-02-28 | 2022-09-23 | Kallyope Inc | Agonistas de gpr40. |
| MX2022014505A (es) | 2020-05-19 | 2022-12-13 | Kallyope Inc | Activadores de la ampk. |
| CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
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| US3108117A (en) | 1959-02-12 | 1963-10-22 | Mead Johnson & Co | 3-benzyl-1, 2-diloweralkyl-3-pyrrolidinols |
| US3778443A (en) | 1969-02-13 | 1973-12-11 | Ciba Geigy Ag | 4-tetrahydro pyridyl,hydroxy alkyl pyrazoles |
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
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| DE2701705A1 (de) | 1976-01-28 | 1977-08-04 | Sandoz Ag | Neue organische verbindungen, ihre verwendung und herstellung |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| CA1146866A (en) | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
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| WO1996022977A1 (en) | 1995-01-23 | 1996-08-01 | Suntory Limited | Ameliorant or remedy for symptoms caused by ischemic diseases and compounds useful therefor |
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-
2010
- 2010-09-20 EP EP10759779.1A patent/EP2483281B1/en active Active
- 2010-09-20 CA CA2775840A patent/CA2775840C/en active Active
- 2010-09-20 ES ES10759779.1T patent/ES2497566T3/es active Active
- 2010-09-20 US US12/886,470 patent/US8410127B2/en not_active Expired - Fee Related
- 2010-09-20 WO PCT/US2010/049486 patent/WO2011041154A1/en not_active Ceased
- 2010-09-20 JP JP2012532124A patent/JP5909185B2/ja not_active Expired - Fee Related
- 2010-09-20 CN CN201080042922.9A patent/CN102666553B/zh not_active Expired - Fee Related
- 2010-09-22 AR ARP100103461A patent/AR078434A1/es unknown
- 2010-09-30 TW TW099133406A patent/TW201120034A/zh unknown
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2013
- 2013-03-28 US US13/853,000 patent/US8815886B2/en active Active
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2014
- 2014-08-25 US US14/468,253 patent/US9150567B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2483281B1 (en) | 2014-06-04 |
| ES2497566T3 (es) | 2014-09-23 |
| EP2483281A1 (en) | 2012-08-08 |
| CA2775840A1 (en) | 2011-04-07 |
| CA2775840C (en) | 2018-02-06 |
| WO2011041154A1 (en) | 2011-04-07 |
| US9150567B2 (en) | 2015-10-06 |
| JP5909185B2 (ja) | 2016-04-26 |
| AR078434A1 (es) | 2011-11-09 |
| US20140038971A1 (en) | 2014-02-06 |
| CN102666553B (zh) | 2015-05-06 |
| US20110152270A1 (en) | 2011-06-23 |
| JP2013506670A (ja) | 2013-02-28 |
| US8410127B2 (en) | 2013-04-02 |
| HK1174617A1 (en) | 2013-06-14 |
| US20150197518A1 (en) | 2015-07-16 |
| US8815886B2 (en) | 2014-08-26 |
| CN102666553A (zh) | 2012-09-12 |
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