TW201113269A - New compounds, pharmaceutical composition and methods relating thereto - Google Patents
New compounds, pharmaceutical composition and methods relating thereto Download PDFInfo
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- TW201113269A TW201113269A TW099120497A TW99120497A TW201113269A TW 201113269 A TW201113269 A TW 201113269A TW 099120497 A TW099120497 A TW 099120497A TW 99120497 A TW99120497 A TW 99120497A TW 201113269 A TW201113269 A TW 201113269A
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- alkyl
- group
- aryl
- compound
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 87
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 9
- 238000000034 method Methods 0.000 title abstract description 81
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- 150000003839 salts Chemical class 0.000 claims abstract description 37
- 238000011282 treatment Methods 0.000 claims abstract description 22
- 239000012453 solvate Substances 0.000 claims abstract description 13
- -1 cyano, hydroxyl Chemical group 0.000 claims description 86
- 125000000217 alkyl group Chemical group 0.000 claims description 64
- 125000001424 substituent group Chemical group 0.000 claims description 39
- 125000003118 aryl group Chemical group 0.000 claims description 38
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 33
- 125000000623 heterocyclic group Chemical group 0.000 claims description 32
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
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- 208000024891 symptom Diseases 0.000 claims description 18
- 229910052736 halogen Inorganic materials 0.000 claims description 15
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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| US22012509P | 2009-06-24 | 2009-06-24 |
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| WO (1) | WO2010149685A1 (OSRAM) |
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| EP2686312B1 (en) | 2011-03-14 | 2016-08-31 | Boehringer Ingelheim International GmbH | N-cyclopropyl-n-piperidinylbenzamides as gpr119 modulators |
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| CN116655598B (zh) * | 2023-01-11 | 2025-04-25 | 黑龙江中医药大学 | 一种用于降血糖的药物及其制备方法 |
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| AR077214A1 (es) | 2011-08-10 |
| US8481731B2 (en) | 2013-07-09 |
| US20110021491A1 (en) | 2011-01-27 |
| WO2010149685A1 (en) | 2010-12-29 |
| JP2012530758A (ja) | 2012-12-06 |
| EP2445901A1 (en) | 2012-05-02 |
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