TW201028378A - Novel substituted octahydrocyclopenta[c]pyrrol-4-amines as calcium channel blockers - Google Patents

Info

Publication number

TW201028378A

TW201028378A TW098140141A TW98140141A TW201028378A TW 201028378 A TW201028378 A TW 201028378A TW 098140141 A TW098140141 A TW 098140141A TW 98140141 A TW98140141 A TW 98140141A TW 201028378 A TW201028378 A TW 201028378A

Authority

TW

Taiwan

Prior art keywords

octahydrocyclopenta

pyrrol

trifluoromethyl

methyl

phenyl

Prior art date

2008-11-26

Links

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• 239000000480 calcium channel blocker Substances 0.000 title description 23
• 150000001875 compounds Chemical class 0.000 claims abstract description 554
• -1 nitro, keto, phenyl Chemical group 0.000 claims description 287
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 272
• 125000000217 alkyl group Chemical group 0.000 claims description 151
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• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 139
• 125000003118 aryl group Chemical group 0.000 claims description 132
• 229910052739 hydrogen Inorganic materials 0.000 claims description 131
• 239000001257 hydrogen Substances 0.000 claims description 131
• 150000001412 amines Chemical class 0.000 claims description 112
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• 125000001072 heteroaryl group Chemical group 0.000 claims description 71
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• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 69
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