AR074226A1 - Octahidrociclopenta[c]pirrol-4-aminas sustituidas como bloqueantes de los canales de calcio, composiciones farmaceuticas que las comprenden y el uso de las mismas para el tratamiento del dolor. - Google Patents
Octahidrociclopenta[c]pirrol-4-aminas sustituidas como bloqueantes de los canales de calcio, composiciones farmaceuticas que las comprenden y el uso de las mismas para el tratamiento del dolor.Info
- Publication number
- AR074226A1 AR074226A1 ARP090104557A ARP090104557A AR074226A1 AR 074226 A1 AR074226 A1 AR 074226A1 AR P090104557 A ARP090104557 A AR P090104557A AR P090104557 A ARP090104557 A AR P090104557A AR 074226 A1 AR074226 A1 AR 074226A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- haloalkyl
- aryl
- independently
- pyrrol
- Prior art date
Links
- 108090000312 Calcium Channels Proteins 0.000 title 1
- 102000003922 Calcium Channels Human genes 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 22
- 125000001188 haloalkyl group Chemical group 0.000 abstract 9
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- -1 nitro, oxo, phenyl Chemical group 0.000 abstract 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- BJLUORNGPCXNHM-UHFFFAOYSA-N 1h-pyrido[3,2-d]pyrimidine-2,4-dione Chemical compound C1=CN=C2C(=O)NC(=O)NC2=C1 BJLUORNGPCXNHM-UHFFFAOYSA-N 0.000 abstract 1
- KWNQIIMVPSMYEM-UHFFFAOYSA-N 6,7-dimethoxy-1h-quinazoline-2,4-dione Chemical compound N1C(=O)NC(=O)C2=C1C=C(OC)C(OC)=C2 KWNQIIMVPSMYEM-UHFFFAOYSA-N 0.000 abstract 1
- GMIUFMBOWKDFBV-UHFFFAOYSA-N CC1C(NC2=C(S1)C=CC=N2)=O Chemical compound CC1C(NC2=C(S1)C=CC=N2)=O GMIUFMBOWKDFBV-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004367 cycloalkylaryl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- YAYWAEXAPGFIKA-UHFFFAOYSA-N n-(1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrol-4-yl)acetamide Chemical compound C1NCC2C(NC(=O)C)CCC21 YAYWAEXAPGFIKA-UHFFFAOYSA-N 0.000 abstract 1
- OCKCLLMPGDCTOY-UHFFFAOYSA-N n-(2-trityl-3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c]pyrrol-4-yl)acetamide Chemical compound C1C2C(NC(=O)C)CCC2CN1C(C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 OCKCLLMPGDCTOY-UHFFFAOYSA-N 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- HODGRZURVLFVKM-UHFFFAOYSA-N tert-butyl n-(1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrol-4-yl)carbamate Chemical compound C1NCC2C(NC(=O)OC(C)(C)C)CCC21 HODGRZURVLFVKM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11799508P | 2008-11-26 | 2008-11-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR074226A1 true AR074226A1 (es) | 2010-12-29 |
Family
ID=42124348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090104557A AR074226A1 (es) | 2008-11-26 | 2009-11-25 | Octahidrociclopenta[c]pirrol-4-aminas sustituidas como bloqueantes de los canales de calcio, composiciones farmaceuticas que las comprenden y el uso de las mismas para el tratamiento del dolor. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8129417B2 (enExample) |
| EP (1) | EP2367790A2 (enExample) |
| JP (1) | JP2012509940A (enExample) |
| KR (1) | KR20110091784A (enExample) |
| CN (1) | CN102292319A (enExample) |
| AR (1) | AR074226A1 (enExample) |
| AU (1) | AU2009319796A1 (enExample) |
| BR (1) | BRPI0921184A2 (enExample) |
| CA (1) | CA2742350A1 (enExample) |
| CL (1) | CL2011001176A1 (enExample) |
| CO (1) | CO6382118A2 (enExample) |
| CR (1) | CR20110304A (enExample) |
| EC (1) | ECSP11011160A (enExample) |
| IL (1) | IL212484A0 (enExample) |
| MX (1) | MX2011005537A (enExample) |
| NZ (1) | NZ592507A (enExample) |
| PA (1) | PA8850301A1 (enExample) |
| PE (1) | PE20110833A1 (enExample) |
| RU (1) | RU2011126215A (enExample) |
| TW (1) | TW201028378A (enExample) |
| UY (1) | UY32261A (enExample) |
| WO (1) | WO2010062927A2 (enExample) |
| ZA (1) | ZA201103538B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102292319A (zh) | 2008-11-26 | 2011-12-21 | 雅培制药有限公司 | 作为钙通道阻滞剂的取代八氢环戊二烯并(c)吡咯-4-胺 |
| MX2011006169A (es) * | 2008-12-12 | 2011-06-27 | Univ Vanderbilt | Inhibidores 3.3.0-biciclicos de giyt1 y metodos para hacer y utilizar los mismos. |
| US8815869B2 (en) | 2010-03-18 | 2014-08-26 | Abbvie Inc. | Lactam acetamides as calcium channel blockers |
| WO2011149995A1 (en) * | 2010-05-25 | 2011-12-01 | Abbott Laboratories | Novel substituted octahydrocyclopenta [c]pyrrol-4-amines as calcium channel blockers |
| WO2011149993A2 (en) * | 2010-05-25 | 2011-12-01 | Abbott Laboratories | SUBSTITUTED OCTAHYDROCYCLOPENTA[c]PYRROLES AS CALCIUM CHANNEL MODULATORS |
| FR2976285B1 (fr) * | 2011-06-08 | 2013-05-24 | Servier Lab | Procede de synthese et forme cristalline du chlorhydrate de 4-{3-[cis-hexahydrocypenta[c]pyrrol-2(1h)-yl]propoxy}benzamide ainsi que les compositions pharmaceutiques qui la contiennent |
| UY34349A (es) | 2011-09-29 | 2013-04-05 | Abb Vie Inc | OCTAHIDROPIRROLO[1,2-a]PIRAZINA SULFONAMIDAS SUSTITUIDAS COMO BLOQUEADORES DE CANALES DE CALCIO |
| WO2013049164A1 (en) | 2011-09-29 | 2013-04-04 | Abbvie Inc. | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS |
| AU2013359533A1 (en) | 2012-12-12 | 2015-05-28 | Abbvie, Inc. | Diazepine derivatives useful as calcium channel blockers in the treatment of pain |
| WO2017063563A1 (zh) * | 2015-10-13 | 2017-04-20 | 四川海思科制药有限公司 | 一种八氢环戊烷并[c]吡咯衍生物及其制备方法和在医药上的用途 |
| JP7447002B2 (ja) * | 2017-09-11 | 2024-03-11 | クルーゾン・ファーマシューティカルズ・インコーポレイテッド | ＳＨＰ２のオクタヒドロシクロペンタ［ｃ］ピロールのアロステリック阻害剤 |
| WO2019173188A1 (en) | 2018-03-05 | 2019-09-12 | Arcus Biosciences, Inc. | Arginase inhibitors |
| AU2020480829A1 (en) | 2020-12-07 | 2023-07-20 | Kimberly-Clark Worldwide, Inc. | Methods and consumer products for detecting a metabolite |
| TWI924832B (zh) * | 2021-04-01 | 2026-05-11 | 日商小野藥品工業股份有限公司 | Abhd6拮抗劑 |
| TW202421635A (zh) | 2022-09-30 | 2024-06-01 | 日商小野藥品工業股份有限公司 | Abhd6拮抗劑 |
| KR20240046089A (ko) | 2022-09-30 | 2024-04-08 | 오노 야꾸힝 고교 가부시키가이샤 | Abhd6 길항제를 함유하는 약학 조성물 |
| JP7852604B2 (ja) * | 2022-09-30 | 2026-04-28 | 小野薬品工業株式会社 | Ａｂｈｄ６アンタゴニストを含有する医薬組成物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0278659A (ja) | 1988-09-12 | 1990-03-19 | Shionogi & Co Ltd | アザビシクロアルカン類化合物 |
| ATE269848T1 (de) * | 1999-04-07 | 2004-07-15 | Univ Virginia | Calciumkanalblocker als antikrebsmittel |
| US8163769B2 (en) * | 2002-03-12 | 2012-04-24 | Abbott Laboratories | Antibacterial compounds |
| US7223754B2 (en) | 2003-03-10 | 2007-05-29 | Dynogen Pharmaceuticals, Inc. | Thiazolidinone, oxazolidinone, and imidazolone derivatives for treating lower urinary tract and related disorders |
| MXPA05009688A (es) * | 2003-03-12 | 2005-12-05 | Abbott Lab | Derivados de naftiridina como agentes antibacterianos. |
| US7230022B2 (en) * | 2004-02-19 | 2007-06-12 | Bristol-Myers Squibb Company | Substituted fused bicyclic amines as modulators of chemokine receptor activity |
| US7381738B2 (en) * | 2004-02-19 | 2008-06-03 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
| WO2006012396A1 (en) * | 2004-07-22 | 2006-02-02 | Glaxo Group Limited | Antibacterial agents |
| DE102004039789A1 (de) * | 2004-08-16 | 2006-03-02 | Sanofi-Aventis Deutschland Gmbh | Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| CA2603876A1 (en) * | 2005-04-19 | 2006-10-26 | Merck & Co., Inc. | N-alkyl-azacycloalkyl nmda/nr2b antagonists |
| EP2350002A1 (en) * | 2008-10-02 | 2011-08-03 | Abbott Laboratories | Novel compounds as calcium channel blockers |
| CN102292319A (zh) | 2008-11-26 | 2011-12-21 | 雅培制药有限公司 | 作为钙通道阻滞剂的取代八氢环戊二烯并(c)吡咯-4-胺 |
| MX2011006169A (es) | 2008-12-12 | 2011-06-27 | Univ Vanderbilt | Inhibidores 3.3.0-biciclicos de giyt1 y metodos para hacer y utilizar los mismos. |
-
2009
- 2009-11-25 CN CN2009801553748A patent/CN102292319A/zh active Pending
- 2009-11-25 AR ARP090104557A patent/AR074226A1/es not_active Application Discontinuation
- 2009-11-25 US US12/625,754 patent/US8129417B2/en not_active Expired - Fee Related
- 2009-11-25 JP JP2011538682A patent/JP2012509940A/ja active Pending
- 2009-11-25 BR BRPI0921184A patent/BRPI0921184A2/pt not_active IP Right Cessation
- 2009-11-25 TW TW098140141A patent/TW201028378A/zh unknown
- 2009-11-25 PA PA20098850301A patent/PA8850301A1/es unknown
- 2009-11-25 WO PCT/US2009/065847 patent/WO2010062927A2/en not_active Ceased
- 2009-11-25 RU RU2011126215/04A patent/RU2011126215A/ru not_active Application Discontinuation
- 2009-11-25 PE PE2011001093A patent/PE20110833A1/es not_active Application Discontinuation
- 2009-11-25 AU AU2009319796A patent/AU2009319796A1/en not_active Abandoned
- 2009-11-25 MX MX2011005537A patent/MX2011005537A/es unknown
- 2009-11-25 NZ NZ592507A patent/NZ592507A/xx not_active IP Right Cessation
- 2009-11-25 KR KR1020117014731A patent/KR20110091784A/ko not_active Withdrawn
- 2009-11-25 CA CA2742350A patent/CA2742350A1/en not_active Abandoned
- 2009-11-25 UY UY0001032261A patent/UY32261A/es not_active Application Discontinuation
- 2009-11-25 EP EP09764953A patent/EP2367790A2/en not_active Withdrawn
-
2011
- 2011-04-26 IL IL212484A patent/IL212484A0/en unknown
- 2011-05-13 ZA ZA2011/03538A patent/ZA201103538B/en unknown
- 2011-05-19 CL CL2011001176A patent/CL2011001176A1/es unknown
- 2011-05-27 CO CO11065858A patent/CO6382118A2/es not_active Application Discontinuation
- 2011-06-06 CR CR20110304A patent/CR20110304A/es not_active Application Discontinuation
- 2011-06-24 EC EC2011011160A patent/ECSP11011160A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2011126215A (ru) | 2013-01-10 |
| MX2011005537A (es) | 2011-06-21 |
| KR20110091784A (ko) | 2011-08-12 |
| CL2011001176A1 (es) | 2011-11-11 |
| CR20110304A (es) | 2011-10-27 |
| ZA201103538B (en) | 2012-11-28 |
| ECSP11011160A (es) | 2011-07-29 |
| WO2010062927A3 (en) | 2010-07-22 |
| AU2009319796A1 (en) | 2010-06-03 |
| BRPI0921184A2 (pt) | 2018-03-13 |
| WO2010062927A2 (en) | 2010-06-03 |
| JP2012509940A (ja) | 2012-04-26 |
| US8129417B2 (en) | 2012-03-06 |
| CN102292319A (zh) | 2011-12-21 |
| PE20110833A1 (es) | 2011-12-21 |
| CO6382118A2 (es) | 2012-02-15 |
| UY32261A (es) | 2010-06-30 |
| PA8850301A1 (es) | 2010-07-27 |
| IL212484A0 (en) | 2011-06-30 |
| CA2742350A1 (en) | 2010-06-03 |
| AU2009319796A8 (en) | 2011-06-30 |
| TW201028378A (en) | 2010-08-01 |
| US20100130558A1 (en) | 2010-05-27 |
| NZ592507A (en) | 2013-08-30 |
| EP2367790A2 (en) | 2011-09-28 |
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