CN102292319A - 作为钙通道阻滞剂的取代八氢环戊二烯并(c)吡咯-4-胺 - Google Patents

作为钙通道阻滞剂的取代八氢环戊二烯并(c)吡咯-4-胺 Download PDF

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Publication number
CN102292319A
CN102292319A CN2009801553748A CN200980155374A CN102292319A CN 102292319 A CN102292319 A CN 102292319A CN 2009801553748 A CN2009801553748 A CN 2009801553748A CN 200980155374 A CN200980155374 A CN 200980155374A CN 102292319 A CN102292319 A CN 102292319A
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China
Prior art keywords
pyrrol
trifluoromethyl
methyl
octahydrocyclopentadieno
sulfonyl
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Pending
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CN2009801553748A
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English (en)
Chinese (zh)
Inventor
A.斯特瓦特
X.西尔勒
D.达扎克
杨铭
S.迪多梅尼科
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AbbVie Inc
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Abbott GmbH and Co KG
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42124348&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102292319(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott GmbH and Co KG filed Critical Abbott GmbH and Co KG
Publication of CN102292319A publication Critical patent/CN102292319A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2009801553748A 2008-11-26 2009-11-25 作为钙通道阻滞剂的取代八氢环戊二烯并(c)吡咯-4-胺 Pending CN102292319A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11799508P 2008-11-26 2008-11-26
US61/117995 2008-11-26
PCT/US2009/065847 WO2010062927A2 (en) 2008-11-26 2009-11-25 Novel substituted octahydrocyclopenta(c)pyrrol-4-amines as calcium channel blockers

Publications (1)

Publication Number Publication Date
CN102292319A true CN102292319A (zh) 2011-12-21

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ID=42124348

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CN2009801553748A Pending CN102292319A (zh) 2008-11-26 2009-11-25 作为钙通道阻滞剂的取代八氢环戊二烯并(c)吡咯-4-胺

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Country Link
US (1) US8129417B2 (enExample)
EP (1) EP2367790A2 (enExample)
JP (1) JP2012509940A (enExample)
KR (1) KR20110091784A (enExample)
CN (1) CN102292319A (enExample)
AR (1) AR074226A1 (enExample)
AU (1) AU2009319796A1 (enExample)
BR (1) BRPI0921184A2 (enExample)
CA (1) CA2742350A1 (enExample)
CL (1) CL2011001176A1 (enExample)
CO (1) CO6382118A2 (enExample)
CR (1) CR20110304A (enExample)
EC (1) ECSP11011160A (enExample)
IL (1) IL212484A0 (enExample)
MX (1) MX2011005537A (enExample)
NZ (1) NZ592507A (enExample)
PA (1) PA8850301A1 (enExample)
PE (1) PE20110833A1 (enExample)
RU (1) RU2011126215A (enExample)
TW (1) TW201028378A (enExample)
UY (1) UY32261A (enExample)
WO (1) WO2010062927A2 (enExample)
ZA (1) ZA201103538B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107849009A (zh) * 2015-10-13 2018-03-27 四川海思科制药有限公司 一种八氢环戊二烯并[c]吡咯衍生物及其制备方法和在医药上的用途
CN111201223A (zh) * 2017-09-11 2020-05-26 克鲁松制药公司 SHP2的八氢环戊二烯并[c]吡咯别构抑制剂

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2011126215A (ru) 2008-11-26 2013-01-10 Эбботт Лэборетриз НОВЫЕ ЗАМЕЩЕННЫЕ ОКТАГИДРОЦИКЛОПЕНТА[c]ПИРРОЛ-4-АМИНЫ В КАЧЕСТВЕ БЛОКАТОРОВ КАЛЬЦИЕВЫХ КАНАЛОВ
US8691865B2 (en) 2008-11-26 2014-04-08 Abbvie Inc. Substituted octahydrocyclopenta[C]pyrrol-4-amines as calcium channel blockers
MX2011006169A (es) * 2008-12-12 2011-06-27 Univ Vanderbilt Inhibidores 3.3.0-biciclicos de giyt1 y metodos para hacer y utilizar los mismos.
WO2011115813A1 (en) * 2010-03-18 2011-09-22 Abbott Laboratories Lactam acetamides as calcium channel blockers
US8796470B2 (en) 2010-05-25 2014-08-05 Abbvie Inc. Substituted octahydrocyclopenta[c]pyrroles as calcium channel modulators
FR2976285B1 (fr) * 2011-06-08 2013-05-24 Servier Lab Procede de synthese et forme cristalline du chlorhydrate de 4-{3-[cis-hexahydrocypenta[c]pyrrol-2(1h)-yl]propoxy}benzamide ainsi que les compositions pharmaceutiques qui la contiennent
US8669255B2 (en) 2011-09-29 2014-03-11 Abbvie Inc. Substituted octahydropyrrolo[1,2-a]pyrazines as calcium channel blockers
US8648074B2 (en) 2011-09-29 2014-02-11 Abbvie Inc. Substituted octahydropyrrolo[1,2-a]pyrazine sulfonamides as calcium channel blockers
EP2931727A1 (en) 2012-12-12 2015-10-21 Abbvie Inc. Diazepine derivatives useful as calcium channel blockers in the treatment of pain
EA202092086A1 (ru) 2018-03-05 2021-02-09 Аркус Байосайенсиз, Инк. Ингибиторы аргиназы
WO2022211060A1 (ja) 2021-04-01 2022-10-06 小野薬品工業株式会社 Ａｂｈｄ６アンタゴニスト
TW202421635A (zh) 2022-09-30 2024-06-01 日商小野藥品工業股份有限公司 Abhd6拮抗劑
JP2024052624A (ja) * 2022-09-30 2024-04-11 小野薬品工業株式会社 Ａｂｈｄ６アンタゴニストを含有する医薬組成物
KR20240046089A (ko) 2022-09-30 2024-04-08 오노 야꾸힝 고교 가부시키가이샤 Abhd6 길항제를 함유하는 약학 조성물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0278659A (ja) 1988-09-12 1990-03-19 Shionogi & Co Ltd アザビシクロアルカン類化合物
ATE269848T1 (de) 1999-04-07 2004-07-15 Univ Virginia Calciumkanalblocker als antikrebsmittel
US8163769B2 (en) * 2002-03-12 2012-04-24 Abbott Laboratories Antibacterial compounds
US7223754B2 (en) 2003-03-10 2007-05-29 Dynogen Pharmaceuticals, Inc. Thiazolidinone, oxazolidinone, and imidazolone derivatives for treating lower urinary tract and related disorders
JP2006514964A (ja) * 2003-03-12 2006-05-18 アボット・ラボラトリーズ 抗菌剤としてのナフチリジン誘導体
US7381738B2 (en) * 2004-02-19 2008-06-03 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
US7230022B2 (en) * 2004-02-19 2007-06-12 Bristol-Myers Squibb Company Substituted fused bicyclic amines as modulators of chemokine receptor activity
JP2008507543A (ja) * 2004-07-22 2008-03-13 グラクソ　グループ　リミテッド 抗細菌剤
DE102004039789A1 (de) * 2004-08-16 2006-03-02 Sanofi-Aventis Deutschland Gmbh Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CA2603876A1 (en) * 2005-04-19 2006-10-26 Merck & Co., Inc. N-alkyl-azacycloalkyl nmda/nr2b antagonists
EP2350002A1 (en) 2008-10-02 2011-08-03 Abbott Laboratories Novel compounds as calcium channel blockers
RU2011126215A (ru) 2008-11-26 2013-01-10 Эбботт Лэборетриз НОВЫЕ ЗАМЕЩЕННЫЕ ОКТАГИДРОЦИКЛОПЕНТА[c]ПИРРОЛ-4-АМИНЫ В КАЧЕСТВЕ БЛОКАТОРОВ КАЛЬЦИЕВЫХ КАНАЛОВ
MX2011006169A (es) 2008-12-12 2011-06-27 Univ Vanderbilt Inhibidores 3.3.0-biciclicos de giyt1 y metodos para hacer y utilizar los mismos.

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107849009A (zh) * 2015-10-13 2018-03-27 四川海思科制药有限公司 一种八氢环戊二烯并[c]吡咯衍生物及其制备方法和在医药上的用途
CN107849008A (zh) * 2015-10-13 2018-03-27 四川海思科制药有限公司 一种八氢环戊烷并[c]吡咯衍生物及其制备方法和在医药上的用途
CN107849009B (zh) * 2015-10-13 2021-03-02 四川海思科制药有限公司 一种八氢环戊二烯并[c]吡咯衍生物及其制备方法和在医药上的用途
CN107849008B (zh) * 2015-10-13 2021-04-09 四川海思科制药有限公司 一种八氢环戊烷并[c]吡咯衍生物及其制备方法和在医药上的用途
CN111201223A (zh) * 2017-09-11 2020-05-26 克鲁松制药公司 SHP2的八氢环戊二烯并[c]吡咯别构抑制剂

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CL2011001176A1 (es) 2011-11-11
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ECSP11011160A (es) 2011-07-29
EP2367790A2 (en) 2011-09-28
WO2010062927A3 (en) 2010-07-22
AU2009319796A1 (en) 2010-06-03
CO6382118A2 (es) 2012-02-15
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KR20110091784A (ko) 2011-08-12
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IL212484A0 (en) 2011-06-30
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US8129417B2 (en) 2012-03-06

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