CL2011001176A1 - Compuestos octahidrociclopenta[c]pirrol-4-amina sustituidos, bloqueadores de los canales de calcio; composicion farmaceutica; y su uso en el tratamiento del dolor, tal como dolor agudo, dolor cronico y dolor neuropatico y para trastornos del sistema nervioso central tales como accidente cerebrovascular y epilepsia, entre otros. - Google Patents

Compuestos octahidrociclopenta[c]pirrol-4-amina sustituidos, bloqueadores de los canales de calcio; composicion farmaceutica; y su uso en el tratamiento del dolor, tal como dolor agudo, dolor cronico y dolor neuropatico y para trastornos del sistema nervioso central tales como accidente cerebrovascular y epilepsia, entre otros.

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Publication number
CL2011001176A1
CL2011001176A1 CL2011001176A CL2011001176A CL2011001176A1 CL 2011001176 A1 CL2011001176 A1 CL 2011001176A1 CL 2011001176 A CL2011001176 A CL 2011001176A CL 2011001176 A CL2011001176 A CL 2011001176A CL 2011001176 A1 CL2011001176 A1 CL 2011001176A1
Authority
CL
Chile
Prior art keywords
pain
pyrrol
epilepsy
disorders
stroke
Prior art date
Application number
CL2011001176A
Other languages
English (en)
Inventor
Andrew Stewart
Xenia Searle
Daria Darczak
Ming YEUNG
Stanley Didomenico
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42124348&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2011001176(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of CL2011001176A1 publication Critical patent/CL2011001176A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos octahidrociclopenta[c]pirrol-4-amina sustituidos, bloqueadores de los canales de calcio; composición farmacéutica; y su uso en el tratamiento del dolor, tal como dolor agudo, dolor crónico y dolor neuropático y para trastornos del sistema nervioso central tales como accidente cerebrovascular y epilepsia, entre otros.
CL2011001176A 2008-11-26 2011-05-19 Compuestos octahidrociclopenta[c]pirrol-4-amina sustituidos, bloqueadores de los canales de calcio; composicion farmaceutica; y su uso en el tratamiento del dolor, tal como dolor agudo, dolor cronico y dolor neuropatico y para trastornos del sistema nervioso central tales como accidente cerebrovascular y epilepsia, entre otros. CL2011001176A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11799508P 2008-11-26 2008-11-26

Publications (1)

Publication Number Publication Date
CL2011001176A1 true CL2011001176A1 (es) 2011-11-11

Family

ID=42124348

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011001176A CL2011001176A1 (es) 2008-11-26 2011-05-19 Compuestos octahidrociclopenta[c]pirrol-4-amina sustituidos, bloqueadores de los canales de calcio; composicion farmaceutica; y su uso en el tratamiento del dolor, tal como dolor agudo, dolor cronico y dolor neuropatico y para trastornos del sistema nervioso central tales como accidente cerebrovascular y epilepsia, entre otros.

Country Status (23)

Country Link
US (1) US8129417B2 (es)
EP (1) EP2367790A2 (es)
JP (1) JP2012509940A (es)
KR (1) KR20110091784A (es)
CN (1) CN102292319A (es)
AR (1) AR074226A1 (es)
AU (1) AU2009319796A1 (es)
BR (1) BRPI0921184A2 (es)
CA (1) CA2742350A1 (es)
CL (1) CL2011001176A1 (es)
CO (1) CO6382118A2 (es)
CR (1) CR20110304A (es)
EC (1) ECSP11011160A (es)
IL (1) IL212484A0 (es)
MX (1) MX2011005537A (es)
NZ (1) NZ592507A (es)
PA (1) PA8850301A1 (es)
PE (1) PE20110833A1 (es)
RU (1) RU2011126215A (es)
TW (1) TW201028378A (es)
UY (1) UY32261A (es)
WO (1) WO2010062927A2 (es)
ZA (1) ZA201103538B (es)

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Publication number Priority date Publication date Assignee Title
MX2011005537A (es) 2008-11-26 2011-06-21 Abbott Lab Nuevas octahidrociclopenta[c]pirrol-4-aminas sustituidas como bloqueadores del canal de calcio.
US8691865B2 (en) 2008-11-26 2014-04-08 Abbvie Inc. Substituted octahydrocyclopenta[C]pyrrol-4-amines as calcium channel blockers
WO2010068851A1 (en) * 2008-12-12 2010-06-17 Vanderbilt Universtiy 3.3.0 bicyclic glyt1 inhibitors and methods of making and using same
US8815869B2 (en) 2010-03-18 2014-08-26 Abbvie Inc. Lactam acetamides as calcium channel blockers
US8796470B2 (en) 2010-05-25 2014-08-05 Abbvie Inc. Substituted octahydrocyclopenta[c]pyrroles as calcium channel modulators
FR2976285B1 (fr) * 2011-06-08 2013-05-24 Servier Lab Procede de synthese et forme cristalline du chlorhydrate de 4-{3-[cis-hexahydrocypenta[c]pyrrol-2(1h)-yl]propoxy}benzamide ainsi que les compositions pharmaceutiques qui la contiennent
WO2013049164A1 (en) 2011-09-29 2013-04-04 Abbvie Inc. SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS
WO2013049174A1 (en) 2011-09-29 2013-04-04 Abbvie Inc. Substituted octahydropyrrolo[1,2-a]pyrazine sulfonamides as calcium channel blockers
BR112015013948A2 (pt) 2012-12-12 2017-07-11 Abbvie Inc derivados diazepínicos úteis como bloqueadores do canal de cálcio no tratamento de dor
CN107849009B (zh) * 2015-10-13 2021-03-02 四川海思科制药有限公司 一种八氢环戊二烯并[c]吡咯衍生物及其制备方法和在医药上的用途
MA50245A (fr) * 2017-09-11 2020-07-22 Krouzon Pharmaceuticals Inc Inhibiteurs allostériques octahydrocyclopenta[c]pyrrole de shp2
JPWO2022211060A1 (es) * 2021-04-01 2022-10-06
KR20240046089A (ko) 2022-09-30 2024-04-08 오노 야꾸힝 고교 가부시키가이샤 Abhd6 길항제를 함유하는 약학 조성물

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JPH0278659A (ja) * 1988-09-12 1990-03-19 Shionogi & Co Ltd アザビシクロアルカン類化合物
JP4932994B2 (ja) 1999-04-07 2012-05-16 ユニバーシテイ・オブ・バージニア・パテント・フアウンデーシヨン 抗癌性カルシウムチャンネル遮断薬
US8163769B2 (en) * 2002-03-12 2012-04-24 Abbott Laboratories Antibacterial compounds
US7223754B2 (en) * 2003-03-10 2007-05-29 Dynogen Pharmaceuticals, Inc. Thiazolidinone, oxazolidinone, and imidazolone derivatives for treating lower urinary tract and related disorders
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US7381738B2 (en) 2004-02-19 2008-06-03 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
US7230022B2 (en) * 2004-02-19 2007-06-12 Bristol-Myers Squibb Company Substituted fused bicyclic amines as modulators of chemokine receptor activity
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CA2603876A1 (en) 2005-04-19 2006-10-26 Merck & Co., Inc. N-alkyl-azacycloalkyl nmda/nr2b antagonists
JP2012504640A (ja) * 2008-10-02 2012-02-23 アボット・ラボラトリーズ カルシウムチャネル遮断薬としての新規な化合物
MX2011005537A (es) 2008-11-26 2011-06-21 Abbott Lab Nuevas octahidrociclopenta[c]pirrol-4-aminas sustituidas como bloqueadores del canal de calcio.
WO2010068851A1 (en) 2008-12-12 2010-06-17 Vanderbilt Universtiy 3.3.0 bicyclic glyt1 inhibitors and methods of making and using same

Also Published As

Publication number Publication date
TW201028378A (en) 2010-08-01
AU2009319796A1 (en) 2010-06-03
CO6382118A2 (es) 2012-02-15
JP2012509940A (ja) 2012-04-26
CA2742350A1 (en) 2010-06-03
UY32261A (es) 2010-06-30
WO2010062927A3 (en) 2010-07-22
NZ592507A (en) 2013-08-30
US20100130558A1 (en) 2010-05-27
CN102292319A (zh) 2011-12-21
RU2011126215A (ru) 2013-01-10
ZA201103538B (en) 2012-11-28
MX2011005537A (es) 2011-06-21
IL212484A0 (en) 2011-06-30
KR20110091784A (ko) 2011-08-12
BRPI0921184A2 (pt) 2018-03-13
EP2367790A2 (en) 2011-09-28
PE20110833A1 (es) 2011-12-21
PA8850301A1 (es) 2010-07-27
AR074226A1 (es) 2010-12-29
CR20110304A (es) 2011-10-27
AU2009319796A8 (en) 2011-06-30
ECSP11011160A (es) 2011-07-29
WO2010062927A2 (en) 2010-06-03
US8129417B2 (en) 2012-03-06

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