TW201024309A - A triazolothiadiazole inhibitor of c-Met protein kinase - Google Patents
A triazolothiadiazole inhibitor of c-Met protein kinase Download PDFInfo
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- TW201024309A TW201024309A TW098139384A TW98139384A TW201024309A TW 201024309 A TW201024309 A TW 201024309A TW 098139384 A TW098139384 A TW 098139384A TW 98139384 A TW98139384 A TW 98139384A TW 201024309 A TW201024309 A TW 201024309A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
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| US11603308P | 2008-11-19 | 2008-11-19 |
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| TW201024309A true TW201024309A (en) | 2010-07-01 |
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| EP2166008A1 (en) * | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
| EP2166010A1 (en) * | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
| BRPI0921509A2 (pt) * | 2008-11-19 | 2016-03-08 | Vertex Pharma | inibidor triazolotiadiazol de proteína quinase c-met |
| MX2011012522A (es) * | 2009-05-28 | 2012-02-08 | Vertex Pharma | Inhibidores de pirazol sustituido de proteina cinasa c-met. |
| CN102448969A (zh) | 2009-05-28 | 2012-05-09 | 沃泰克斯药物股份有限公司 | C-met蛋白激酶抑制剂 |
| SG176574A1 (en) * | 2009-05-28 | 2012-01-30 | Vertex Pharma | Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase |
| CN109283279B (zh) * | 2017-07-21 | 2019-11-01 | 南京正大天晴制药有限公司 | 通过高效液相色谱法分离测定雷替曲塞及其对映异构体的方法 |
| CN109897054B (zh) * | 2017-12-08 | 2021-12-10 | 中国药科大学 | 三唑并噻二唑类c-Met激酶抑制剂的制备方法及其用途 |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
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| JP5144532B2 (ja) * | 2005-11-30 | 2013-02-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | ｃ−Ｍｅｔ阻害剤及び用法 |
| CA2651979A1 (en) * | 2006-05-30 | 2007-12-06 | Pfizer Products Inc. | Triazolopyridazine derivatives |
| WO2008144767A1 (en) * | 2007-05-21 | 2008-11-27 | Sgx Pharmaceuticals, Inc. | Heterocyclic kinase modulators |
| BRPI0921509A2 (pt) * | 2008-11-19 | 2016-03-08 | Vertex Pharma | inibidor triazolotiadiazol de proteína quinase c-met |
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| KR20110094285A (ko) | 2011-08-23 |
| JP2012509279A (ja) | 2012-04-19 |
| NZ592825A (en) | 2013-01-25 |
| EP2365977A1 (en) | 2011-09-21 |
| ES2393693T3 (es) | 2012-12-27 |
| CA2743000A1 (en) | 2010-05-27 |
| US20110207774A1 (en) | 2011-08-25 |
| WO2010059668A1 (en) | 2010-05-27 |
| IL212906A0 (en) | 2011-07-31 |
| ZA201103170B (en) | 2012-08-29 |
| MX2011005250A (es) | 2011-07-29 |
| US8217056B2 (en) | 2012-07-10 |
| JP5596047B2 (ja) | 2014-09-24 |
| RU2011124894A (ru) | 2012-12-27 |
| CN102216309A (zh) | 2011-10-12 |
| AR074379A1 (es) | 2011-01-12 |
| US20100234423A1 (en) | 2010-09-16 |
| EP2365977B1 (en) | 2012-10-03 |
| AU2009316756A1 (en) | 2010-05-27 |
| CN102216309B (zh) | 2014-05-07 |
| AU2009316756B2 (en) | 2016-02-25 |
| US20110301195A1 (en) | 2011-12-08 |
| US8343998B2 (en) | 2013-01-01 |
| CL2011001152A1 (es) | 2012-02-24 |
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