AR074379A1 - Inhibidor de triazolotiadiazola de la proteina quinasa c-met - Google Patents

Inhibidor de triazolotiadiazola de la proteina quinasa c-met

Info

Publication number
AR074379A1
AR074379A1 ARP090104468A ARP090104468A AR074379A1 AR 074379 A1 AR074379 A1 AR 074379A1 AR P090104468 A ARP090104468 A AR P090104468A AR P090104468 A ARP090104468 A AR P090104468A AR 074379 A1 AR074379 A1 AR 074379A1
Authority
AR
Argentina
Prior art keywords
met
triazolotiadiazola
inhibitor
quinasa
protein
Prior art date
Application number
ARP090104468A
Other languages
English (en)
Spanish (es)
Inventor
David J Lauffer
Pan Li
Dean Shannon
Jianglin Liang
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of AR074379A1 publication Critical patent/AR074379A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ARP090104468A 2008-11-19 2009-11-19 Inhibidor de triazolotiadiazola de la proteina quinasa c-met AR074379A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11603308P 2008-11-19 2008-11-19

Publications (1)

Publication Number Publication Date
AR074379A1 true AR074379A1 (es) 2011-01-12

Family

ID=42027848

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090104468A AR074379A1 (es) 2008-11-19 2009-11-19 Inhibidor de triazolotiadiazola de la proteina quinasa c-met

Country Status (18)

Country Link
US (3) US8217056B2 (enExample)
EP (1) EP2365977B1 (enExample)
JP (1) JP5596047B2 (enExample)
KR (1) KR20110094285A (enExample)
CN (1) CN102216309B (enExample)
AR (1) AR074379A1 (enExample)
AU (1) AU2009316756B2 (enExample)
BR (1) BRPI0921509A2 (enExample)
CA (1) CA2743000A1 (enExample)
CL (1) CL2011001152A1 (enExample)
ES (1) ES2393693T3 (enExample)
IL (1) IL212906A0 (enExample)
MX (1) MX2011005250A (enExample)
NZ (1) NZ592825A (enExample)
RU (1) RU2011124894A (enExample)
TW (1) TW201024309A (enExample)
WO (1) WO2010059668A1 (enExample)
ZA (1) ZA201103170B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2166010A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166008A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
JP5596047B2 (ja) * 2008-11-19 2014-09-24 バーテックス ファーマシューティカルズ インコーポレイテッド ｃ−Ｍｅｔタンパク質キナーゼのトリアゾロチアジアゾール阻害剤
SI2435443T1 (sl) * 2009-05-28 2013-12-31 Vertex Pharmaceuticals Incorporated Aminopirazol triazolotiadiazolni inhibitorji c-met protein kinaze
CA2762186A1 (en) * 2009-05-28 2010-12-02 Vertex Pharmaceuticals Incorporated Substituted pyrazole inhibitors of c-met protein kinase
WO2010138673A1 (en) * 2009-05-28 2010-12-02 Vertex Pharmaceuticals Incorporated Inhibitors of c-met protein kinase
CN109283279B (zh) * 2017-07-21 2019-11-01 南京正大天晴制药有限公司 通过高效液相色谱法分离测定雷替曲塞及其对映异构体的方法
CN109897054B (zh) * 2017-12-08 2021-12-10 中国药科大学 三唑并噻二唑类c-Met激酶抑制剂的制备方法及其用途
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080080584A (ko) * 2005-11-30 2008-09-04 버텍스 파마슈티칼스 인코포레이티드 ｃ-Ｍｅｔ의 억제제 및 이의 용도
JP2009538899A (ja) * 2006-05-30 2009-11-12 ファイザー・プロダクツ・インク トリアゾロピリダジン誘導体
CN101678014B (zh) * 2007-05-21 2012-12-12 Sgx药品公司 杂环激酶调节剂
JP5596047B2 (ja) * 2008-11-19 2014-09-24 バーテックス ファーマシューティカルズ インコーポレイテッド ｃ−Ｍｅｔタンパク質キナーゼのトリアゾロチアジアゾール阻害剤

Also Published As

Publication number Publication date
US20110207774A1 (en) 2011-08-25
KR20110094285A (ko) 2011-08-23
AU2009316756A1 (en) 2010-05-27
TW201024309A (en) 2010-07-01
US8343998B2 (en) 2013-01-01
EP2365977B1 (en) 2012-10-03
CA2743000A1 (en) 2010-05-27
WO2010059668A1 (en) 2010-05-27
BRPI0921509A2 (pt) 2016-03-08
ZA201103170B (en) 2012-08-29
US20100234423A1 (en) 2010-09-16
AU2009316756B2 (en) 2016-02-25
NZ592825A (en) 2013-01-25
IL212906A0 (en) 2011-07-31
JP2012509279A (ja) 2012-04-19
EP2365977A1 (en) 2011-09-21
CL2011001152A1 (es) 2012-02-24
JP5596047B2 (ja) 2014-09-24
US8217056B2 (en) 2012-07-10
CN102216309A (zh) 2011-10-12
ES2393693T3 (es) 2012-12-27
MX2011005250A (es) 2011-07-29
US20110301195A1 (en) 2011-12-08
RU2011124894A (ru) 2012-12-27
CN102216309B (zh) 2014-05-07

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