AU2009316756B2 - A triazolothiadiazole inhibitor of c-Met protein kinase - Google Patents

A triazolothiadiazole inhibitor of c-Met protein kinase Download PDF

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Publication number
AU2009316756B2
AU2009316756B2 AU2009316756A AU2009316756A AU2009316756B2 AU 2009316756 B2 AU2009316756 B2 AU 2009316756B2 AU 2009316756 A AU2009316756 A AU 2009316756A AU 2009316756 A AU2009316756 A AU 2009316756A AU 2009316756 B2 AU2009316756 B2 AU 2009316756B2
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AU
Australia
Prior art keywords
compound
pharmaceutically acceptable
agents
compositions
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2009316756A
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English (en)
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AU2009316756A1 (en
Inventor
David Lauffer
Pan Li
Jianglin Liang
Dean Shannon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of AU2009316756A1 publication Critical patent/AU2009316756A1/en
Application granted granted Critical
Publication of AU2009316756B2 publication Critical patent/AU2009316756B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2009316756A 2008-11-19 2009-11-18 A triazolothiadiazole inhibitor of c-Met protein kinase Ceased AU2009316756B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11603308P 2008-11-19 2008-11-19
US61/116,033 2008-11-19
PCT/US2009/064909 WO2010059668A1 (en) 2008-11-19 2009-11-18 A triazolothiadiazole inhibitor of c-met protein kinase

Publications (2)

Publication Number Publication Date
AU2009316756A1 AU2009316756A1 (en) 2010-05-27
AU2009316756B2 true AU2009316756B2 (en) 2016-02-25

Family

ID=42027848

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009316756A Ceased AU2009316756B2 (en) 2008-11-19 2009-11-18 A triazolothiadiazole inhibitor of c-Met protein kinase

Country Status (18)

Country Link
US (3) US8217056B2 (enExample)
EP (1) EP2365977B1 (enExample)
JP (1) JP5596047B2 (enExample)
KR (1) KR20110094285A (enExample)
CN (1) CN102216309B (enExample)
AR (1) AR074379A1 (enExample)
AU (1) AU2009316756B2 (enExample)
BR (1) BRPI0921509A2 (enExample)
CA (1) CA2743000A1 (enExample)
CL (1) CL2011001152A1 (enExample)
ES (1) ES2393693T3 (enExample)
IL (1) IL212906A0 (enExample)
MX (1) MX2011005250A (enExample)
NZ (1) NZ592825A (enExample)
RU (1) RU2011124894A (enExample)
TW (1) TW201024309A (enExample)
WO (1) WO2010059668A1 (enExample)
ZA (1) ZA201103170B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2166010A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166008A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
JP5596047B2 (ja) * 2008-11-19 2014-09-24 バーテックス ファーマシューティカルズ インコーポレイテッド ｃ−Ｍｅｔタンパク質キナーゼのトリアゾロチアジアゾール阻害剤
SI2435443T1 (sl) * 2009-05-28 2013-12-31 Vertex Pharmaceuticals Incorporated Aminopirazol triazolotiadiazolni inhibitorji c-met protein kinaze
CA2762186A1 (en) * 2009-05-28 2010-12-02 Vertex Pharmaceuticals Incorporated Substituted pyrazole inhibitors of c-met protein kinase
WO2010138673A1 (en) * 2009-05-28 2010-12-02 Vertex Pharmaceuticals Incorporated Inhibitors of c-met protein kinase
CN109283279B (zh) * 2017-07-21 2019-11-01 南京正大天晴制药有限公司 通过高效液相色谱法分离测定雷替曲塞及其对映异构体的方法
CN109897054B (zh) * 2017-12-08 2021-12-10 中国药科大学 三唑并噻二唑类c-Met激酶抑制剂的制备方法及其用途
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007064797A2 (en) * 2005-11-30 2007-06-07 Vertex Pharmaceuticals Incorporated Inhibitors of c-met and uses thereof
WO2007138472A2 (en) * 2006-05-30 2007-12-06 Pfizer Products Inc. Triazolopyridazine derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101678014B (zh) * 2007-05-21 2012-12-12 Sgx药品公司 杂环激酶调节剂
JP5596047B2 (ja) * 2008-11-19 2014-09-24 バーテックス ファーマシューティカルズ インコーポレイテッド ｃ−Ｍｅｔタンパク質キナーゼのトリアゾロチアジアゾール阻害剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007064797A2 (en) * 2005-11-30 2007-06-07 Vertex Pharmaceuticals Incorporated Inhibitors of c-met and uses thereof
WO2007138472A2 (en) * 2006-05-30 2007-12-06 Pfizer Products Inc. Triazolopyridazine derivatives

Also Published As

Publication number Publication date
US20110207774A1 (en) 2011-08-25
AR074379A1 (es) 2011-01-12
KR20110094285A (ko) 2011-08-23
AU2009316756A1 (en) 2010-05-27
TW201024309A (en) 2010-07-01
US8343998B2 (en) 2013-01-01
EP2365977B1 (en) 2012-10-03
CA2743000A1 (en) 2010-05-27
WO2010059668A1 (en) 2010-05-27
BRPI0921509A2 (pt) 2016-03-08
ZA201103170B (en) 2012-08-29
US20100234423A1 (en) 2010-09-16
NZ592825A (en) 2013-01-25
IL212906A0 (en) 2011-07-31
JP2012509279A (ja) 2012-04-19
EP2365977A1 (en) 2011-09-21
CL2011001152A1 (es) 2012-02-24
JP5596047B2 (ja) 2014-09-24
US8217056B2 (en) 2012-07-10
CN102216309A (zh) 2011-10-12
ES2393693T3 (es) 2012-12-27
MX2011005250A (es) 2011-07-29
US20110301195A1 (en) 2011-12-08
RU2011124894A (ru) 2012-12-27
CN102216309B (zh) 2014-05-07

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
GM Mortgages registered

Name of requester: MACQUARIE US TRADING LLC

GMD Discharge of a mortgage

Effective date: 20160913

MK14 Patent ceased section 143(a) (annual fees not paid) or expired