CL2011001152A1 - Compuesto cristalino 6-((s)-1-(6-(1-metil-1h-pirazol-4-il)-[1,2,4]triazolo[3,4-b][1,3,4]tiadiazol-3-il)etil)quinolina, inhibidor de la proteina kinasa c-met; composicion farmaceutica; y metodo para tratar o disminuir la gravedad de un trastorno proliferativo tal como cancer metastasico de colon, mama y hepatico, entre otros. - Google Patents
Compuesto cristalino 6-((s)-1-(6-(1-metil-1h-pirazol-4-il)-[1,2,4]triazolo[3,4-b][1,3,4]tiadiazol-3-il)etil)quinolina, inhibidor de la proteina kinasa c-met; composicion farmaceutica; y metodo para tratar o disminuir la gravedad de un trastorno proliferativo tal como cancer metastasico de colon, mama y hepatico, entre otros.Info
- Publication number
- CL2011001152A1 CL2011001152A1 CL2011001152A CL2011001152A CL2011001152A1 CL 2011001152 A1 CL2011001152 A1 CL 2011001152A1 CL 2011001152 A CL2011001152 A CL 2011001152A CL 2011001152 A CL2011001152 A CL 2011001152A CL 2011001152 A1 CL2011001152 A1 CL 2011001152A1
- Authority
- CL
- Chile
- Prior art keywords
- thiadiazol
- triazolo
- pyrazol
- quinoline
- colon
- Prior art date
Links
- AMVSPCWTSDZDPI-NSHDSACASA-N 6-(1-methylpyrazol-4-yl)-3-[(1s)-1-quinolin-6-ylethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole Chemical compound N=1N2C([C@@H](C)C=3C=C4C=CC=NC4=CC=3)=NN=C2SC=1C=1C=NN(C)C=1 AMVSPCWTSDZDPI-NSHDSACASA-N 0.000 title abstract 2
- 208000026310 Breast neoplasm Diseases 0.000 title abstract 2
- 102000008022 Proto-Oncogene Proteins c-met Human genes 0.000 title abstract 2
- 108010089836 Proto-Oncogene Proteins c-met Proteins 0.000 title abstract 2
- 210000000481 breast Anatomy 0.000 title abstract 2
- 210000001072 colon Anatomy 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 229940043355 kinase inhibitor Drugs 0.000 title abstract 2
- 210000004185 liver Anatomy 0.000 title abstract 2
- 208000014018 liver neoplasm Diseases 0.000 title abstract 2
- 208000037819 metastatic cancer Diseases 0.000 title abstract 2
- 208000011575 metastatic malignant neoplasm Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000002062 proliferating effect Effects 0.000 title abstract 2
- 239000003909 protein kinase inhibitor Substances 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11603308P | 2008-11-19 | 2008-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2011001152A1 true CL2011001152A1 (es) | 2012-02-24 |
Family
ID=42027848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2011001152A CL2011001152A1 (es) | 2008-11-19 | 2011-05-18 | Compuesto cristalino 6-((s)-1-(6-(1-metil-1h-pirazol-4-il)-[1,2,4]triazolo[3,4-b][1,3,4]tiadiazol-3-il)etil)quinolina, inhibidor de la proteina kinasa c-met; composicion farmaceutica; y metodo para tratar o disminuir la gravedad de un trastorno proliferativo tal como cancer metastasico de colon, mama y hepatico, entre otros. |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8217056B2 (enExample) |
| EP (1) | EP2365977B1 (enExample) |
| JP (1) | JP5596047B2 (enExample) |
| KR (1) | KR20110094285A (enExample) |
| CN (1) | CN102216309B (enExample) |
| AR (1) | AR074379A1 (enExample) |
| AU (1) | AU2009316756B2 (enExample) |
| BR (1) | BRPI0921509A2 (enExample) |
| CA (1) | CA2743000A1 (enExample) |
| CL (1) | CL2011001152A1 (enExample) |
| ES (1) | ES2393693T3 (enExample) |
| IL (1) | IL212906A0 (enExample) |
| MX (1) | MX2011005250A (enExample) |
| NZ (1) | NZ592825A (enExample) |
| RU (1) | RU2011124894A (enExample) |
| TW (1) | TW201024309A (enExample) |
| WO (1) | WO2010059668A1 (enExample) |
| ZA (1) | ZA201103170B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2166010A1 (en) * | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
| EP2166008A1 (en) * | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
| WO2010059668A1 (en) * | 2008-11-19 | 2010-05-27 | Vertex Pharmaceuticals Incorporated | A triazolothiadiazole inhibitor of c-met protein kinase |
| CA2762190A1 (en) * | 2009-05-28 | 2010-12-02 | Vertex Pharmaceuticals Incorporated | Aminopyrazole triazolothiadiazole inhibitors of c-met protein kinase |
| JP2012528188A (ja) | 2009-05-28 | 2012-11-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | ｃ−Ｍｅｔタンパク質キナーゼの阻害剤 |
| US8269012B2 (en) * | 2009-05-28 | 2012-09-18 | Vertex Pharmaceuticals Incorporated | Aminopyrazole triazolothiadiazole inhibitors of c-met protein kinase |
| CN109283279B (zh) * | 2017-07-21 | 2019-11-01 | 南京正大天晴制药有限公司 | 通过高效液相色谱法分离测定雷替曲塞及其对映异构体的方法 |
| CN109897054B (zh) * | 2017-12-08 | 2021-12-10 | 中国药科大学 | 三唑并噻二唑类c-Met激酶抑制剂的制备方法及其用途 |
| MX2021009863A (es) | 2019-03-21 | 2021-11-12 | Onxeo | Una molecula dbait en combinacion con inhibidor de quinasa para el tratamiento del cancer. |
| WO2021089791A1 (en) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2630884A1 (en) | 2005-11-30 | 2007-06-07 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-met and uses thereof |
| JP2009538899A (ja) | 2006-05-30 | 2009-11-12 | ファイザー・プロダクツ・インク | トリアゾロピリダジン誘導体 |
| EA200971077A1 (ru) * | 2007-05-21 | 2010-04-30 | ЭсДжиЭкс ФАРМАСЬЮТИКАЛЗ, ИНК. | Гетероциклические модуляторы киназы |
| WO2010059668A1 (en) * | 2008-11-19 | 2010-05-27 | Vertex Pharmaceuticals Incorporated | A triazolothiadiazole inhibitor of c-met protein kinase |
-
2009
- 2009-11-18 WO PCT/US2009/064909 patent/WO2010059668A1/en not_active Ceased
- 2009-11-18 MX MX2011005250A patent/MX2011005250A/es active IP Right Grant
- 2009-11-18 BR BRPI0921509A patent/BRPI0921509A2/pt not_active Application Discontinuation
- 2009-11-18 EP EP09756109A patent/EP2365977B1/en active Active
- 2009-11-18 KR KR1020117011277A patent/KR20110094285A/ko not_active Withdrawn
- 2009-11-18 RU RU2011124894/04A patent/RU2011124894A/ru unknown
- 2009-11-18 US US12/620,845 patent/US8217056B2/en not_active Expired - Fee Related
- 2009-11-18 NZ NZ592825A patent/NZ592825A/xx not_active IP Right Cessation
- 2009-11-18 CN CN200980146238.2A patent/CN102216309B/zh not_active Expired - Fee Related
- 2009-11-18 CA CA2743000A patent/CA2743000A1/en not_active Abandoned
- 2009-11-18 AU AU2009316756A patent/AU2009316756B2/en not_active Ceased
- 2009-11-18 ES ES09756109T patent/ES2393693T3/es active Active
- 2009-11-18 JP JP2011536613A patent/JP5596047B2/ja not_active Expired - Fee Related
- 2009-11-19 AR ARP090104468A patent/AR074379A1/es unknown
- 2009-11-19 TW TW098139384A patent/TW201024309A/zh unknown
-
2011
- 2011-04-29 ZA ZA2011/03170A patent/ZA201103170B/en unknown
- 2011-05-03 US US13/099,643 patent/US8343998B2/en not_active Expired - Fee Related
- 2011-05-16 IL IL212906A patent/IL212906A0/en unknown
- 2011-05-18 CL CL2011001152A patent/CL2011001152A1/es unknown
- 2011-08-10 US US13/206,954 patent/US20110301195A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0921509A2 (pt) | 2016-03-08 |
| EP2365977B1 (en) | 2012-10-03 |
| WO2010059668A1 (en) | 2010-05-27 |
| IL212906A0 (en) | 2011-07-31 |
| JP5596047B2 (ja) | 2014-09-24 |
| KR20110094285A (ko) | 2011-08-23 |
| CN102216309B (zh) | 2014-05-07 |
| NZ592825A (en) | 2013-01-25 |
| TW201024309A (en) | 2010-07-01 |
| JP2012509279A (ja) | 2012-04-19 |
| US20110301195A1 (en) | 2011-12-08 |
| ES2393693T3 (es) | 2012-12-27 |
| AU2009316756A1 (en) | 2010-05-27 |
| AU2009316756B2 (en) | 2016-02-25 |
| MX2011005250A (es) | 2011-07-29 |
| RU2011124894A (ru) | 2012-12-27 |
| ZA201103170B (en) | 2012-08-29 |
| US20100234423A1 (en) | 2010-09-16 |
| US20110207774A1 (en) | 2011-08-25 |
| CN102216309A (zh) | 2011-10-12 |
| US8217056B2 (en) | 2012-07-10 |
| EP2365977A1 (en) | 2011-09-21 |
| CA2743000A1 (en) | 2010-05-27 |
| AR074379A1 (es) | 2011-01-12 |
| US8343998B2 (en) | 2013-01-01 |
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