BRPI0921509A2 - inibidor triazolotiadiazol de proteína quinase c-met - Google Patents

inibidor triazolotiadiazol de proteína quinase c-met

Info

Publication number
BRPI0921509A2
BRPI0921509A2 BRPI0921509A BRPI0921509A BRPI0921509A2 BR PI0921509 A2 BRPI0921509 A2 BR PI0921509A2 BR PI0921509 A BRPI0921509 A BR PI0921509A BR PI0921509 A BRPI0921509 A BR PI0921509A BR PI0921509 A2 BRPI0921509 A2 BR PI0921509A2
Authority
BR
Brazil
Prior art keywords
triazolothiadiazole
protein kinase
kinase inhibitor
met protein
met
Prior art date
Application number
BRPI0921509A
Other languages
English (en)
Portuguese (pt)
Inventor
David Lauffer
Dean Shannon
Jianglin Liang
Pan Li
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of BRPI0921509A2 publication Critical patent/BRPI0921509A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0921509A 2008-11-19 2009-11-18 inibidor triazolotiadiazol de proteína quinase c-met BRPI0921509A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11603308P 2008-11-19 2008-11-19
PCT/US2009/064909 WO2010059668A1 (en) 2008-11-19 2009-11-18 A triazolothiadiazole inhibitor of c-met protein kinase

Publications (1)

Publication Number Publication Date
BRPI0921509A2 true BRPI0921509A2 (pt) 2016-03-08

Family

ID=42027848

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0921509A BRPI0921509A2 (pt) 2008-11-19 2009-11-18 inibidor triazolotiadiazol de proteína quinase c-met

Country Status (18)

Country Link
US (3) US8217056B2 (enExample)
EP (1) EP2365977B1 (enExample)
JP (1) JP5596047B2 (enExample)
KR (1) KR20110094285A (enExample)
CN (1) CN102216309B (enExample)
AR (1) AR074379A1 (enExample)
AU (1) AU2009316756B2 (enExample)
BR (1) BRPI0921509A2 (enExample)
CA (1) CA2743000A1 (enExample)
CL (1) CL2011001152A1 (enExample)
ES (1) ES2393693T3 (enExample)
IL (1) IL212906A0 (enExample)
MX (1) MX2011005250A (enExample)
NZ (1) NZ592825A (enExample)
RU (1) RU2011124894A (enExample)
TW (1) TW201024309A (enExample)
WO (1) WO2010059668A1 (enExample)
ZA (1) ZA201103170B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2166008A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166010A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
MX2011005250A (es) * 2008-11-19 2011-07-29 Vertex Pharma Inhibidores de triazolotiadiazol de cinasa de proteina c-met.
WO2010138673A1 (en) * 2009-05-28 2010-12-02 Vertex Pharmaceuticals Incorporated Inhibitors of c-met protein kinase
UA106082C2 (uk) * 2009-05-28 2014-07-25 Вертекс Фармасьютікалз Інкорпорейтед АМІНОПІРАЗОЛ ТРИАЗОЛОТІАДІАЗОЛЬНІ ІНГІБІТОРИ ПРОТЕЇНКІНАЗИ c-МЕТ
US8269013B2 (en) * 2009-05-28 2012-09-18 Vertex Pharmaceuticals Incorporated Substituted pyrazole inhibitors of c-Met protein kinase
CN109283279B (zh) * 2017-07-21 2019-11-01 南京正大天晴制药有限公司 通过高效液相色谱法分离测定雷替曲塞及其对映异构体的方法
CN109897054B (zh) * 2017-12-08 2021-12-10 中国药科大学 三唑并噻二唑类c-Met激酶抑制剂的制备方法及其用途
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7728017B2 (en) * 2005-11-30 2010-06-01 Vertex Pharmaceuticals Incorporated Inhibitors of c-Met and uses thereof
CA2651979A1 (en) * 2006-05-30 2007-12-06 Pfizer Products Inc. Triazolopyridazine derivatives
US20090156594A1 (en) * 2007-05-21 2009-06-18 Sgx Pharmaceuticals, Inc. Heterocyclic kinase modulators
MX2011005250A (es) * 2008-11-19 2011-07-29 Vertex Pharma Inhibidores de triazolotiadiazol de cinasa de proteina c-met.

Also Published As

Publication number Publication date
US20100234423A1 (en) 2010-09-16
US8217056B2 (en) 2012-07-10
KR20110094285A (ko) 2011-08-23
CN102216309A (zh) 2011-10-12
NZ592825A (en) 2013-01-25
US20110207774A1 (en) 2011-08-25
US8343998B2 (en) 2013-01-01
MX2011005250A (es) 2011-07-29
ES2393693T3 (es) 2012-12-27
EP2365977A1 (en) 2011-09-21
CA2743000A1 (en) 2010-05-27
TW201024309A (en) 2010-07-01
CN102216309B (zh) 2014-05-07
ZA201103170B (en) 2012-08-29
WO2010059668A1 (en) 2010-05-27
AU2009316756A1 (en) 2010-05-27
JP5596047B2 (ja) 2014-09-24
JP2012509279A (ja) 2012-04-19
US20110301195A1 (en) 2011-12-08
RU2011124894A (ru) 2012-12-27
AU2009316756B2 (en) 2016-02-25
AR074379A1 (es) 2011-01-12
CL2011001152A1 (es) 2012-02-24
EP2365977B1 (en) 2012-10-03
IL212906A0 (en) 2011-07-31

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]