TW200911822A - Boron-containing small molecules - Google Patents

Boron-containing small molecules Download PDF

Info

Publication number
TW200911822A
TW200911822A TW097123257A TW97123257A TW200911822A TW 200911822 A TW200911822 A TW 200911822A TW 097123257 A TW097123257 A TW 097123257A TW 97123257 A TW97123257 A TW 97123257A TW 200911822 A TW200911822 A TW 200911822A
Authority
TW
Taiwan
Prior art keywords
group
compound
substituted
unsubstituted
exemplary embodiment
Prior art date
Application number
TW097123257A
Other languages
English (en)
Chinese (zh)
Inventor
Stephen J Baker
Vincent S Hernandez
Rashmi Sharma
James A Nieman
Tsutomu Akama
Yong-Kang Zhang
Jacob J Plattner
Michael Richard Kevin Alley
Rajeshwar Singh
Fernando Rock
Original Assignee
Anacor Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40156702&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200911822(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Anacor Pharmaceuticals Inc filed Critical Anacor Pharmaceuticals Inc
Publication of TW200911822A publication Critical patent/TW200911822A/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW097123257A 2007-06-20 2008-06-20 Boron-containing small molecules TW200911822A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94529407P 2007-06-20 2007-06-20
US4117808P 2008-03-31 2008-03-31

Publications (1)

Publication Number Publication Date
TW200911822A true TW200911822A (en) 2009-03-16

Family

ID=40156702

Family Applications (1)

Application Number Title Priority Date Filing Date
TW097123257A TW200911822A (en) 2007-06-20 2008-06-20 Boron-containing small molecules

Country Status (29)

Country Link
US (4) US7816344B2 (enExample)
EP (1) EP2164331B1 (enExample)
JP (3) JP5530923B2 (enExample)
KR (3) KR20150100945A (enExample)
CN (2) CN101772302B (enExample)
AR (1) AR067105A1 (enExample)
AU (1) AU2008265630B2 (enExample)
BR (1) BRPI0813450B8 (enExample)
CA (1) CA2692135C (enExample)
CL (1) CL2008001855A1 (enExample)
CO (1) CO6251209A2 (enExample)
CR (1) CR11224A (enExample)
DK (1) DK2164331T3 (enExample)
DO (1) DOP2009000281A (enExample)
EA (1) EA020530B1 (enExample)
ES (1) ES2655299T3 (enExample)
IL (1) IL202379A (enExample)
JO (1) JO3396B1 (enExample)
MA (1) MA31675B1 (enExample)
MX (1) MX347688B (enExample)
MY (1) MY162692A (enExample)
NO (1) NO2164331T3 (enExample)
NZ (1) NZ582706A (enExample)
PE (1) PE20090840A1 (enExample)
SG (1) SG182219A1 (enExample)
TW (1) TW200911822A (enExample)
UY (1) UY31171A1 (enExample)
WO (1) WO2008157726A1 (enExample)
ZA (2) ZA200909003B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12482208B2 (en) 2023-05-30 2025-11-25 Snap Inc. Mirroring 3D assets for virtual experiences

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767657B2 (en) 2005-02-16 2010-08-03 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
SI2343304T1 (sl) 2005-02-16 2015-08-31 Anacor Pharmaceuticals, Inc. Biocidne boroftalidne spojine
BRPI0708051A2 (pt) * 2006-02-16 2011-05-17 Anacor Pharmaceuticals Inc moléculas pequenas contendo boro como agentes antiflamatórios
WO2007131072A2 (en) 2006-05-02 2007-11-15 Anacor Pharmaceuticals, Inc. Hydrolytically-resistant boron-containing therapeutics and methods of use
JO3396B1 (ar) 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
NZ587955A (en) 2008-03-06 2012-10-26 Anacor Pharmaceuticals Inc Boron-containing small molecules as anti-inflammatory agents
EP2285384A4 (en) * 2008-05-12 2012-04-25 Anacor Pharmaceuticals Inc BORN SMALL MOLECULES
EP2348863A4 (en) * 2008-09-04 2012-03-07 Anacor Pharmaceuticals Inc BORN SMALL MOLECULES
US8461336B2 (en) 2008-09-04 2013-06-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2010045503A1 (en) * 2008-10-15 2010-04-22 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agents
US8461364B2 (en) * 2008-12-17 2013-06-11 Glaxosmithkline Llc Polymorphs of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[C][1,2]oxaborol-1-OL
US8668911B2 (en) * 2009-05-14 2014-03-11 The Regents Of The University Of Michigan Streptococcus vaccine compositions and methods of using the same
JP2013500974A (ja) * 2009-07-28 2013-01-10 アナコール ファーマシューティカルズ,インコーポレイテッド 三置換ホウ素含有分子
US9440994B2 (en) * 2009-08-14 2016-09-13 Anacor Pharmaceuticals, Inc. Boron containing small molecules as antiprotozoal agents
WO2011019612A1 (en) 2009-08-14 2011-02-17 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
WO2011019616A1 (en) 2009-08-14 2011-02-17 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
US20110207701A1 (en) * 2009-08-19 2011-08-25 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
WO2011037731A1 (en) * 2009-09-25 2011-03-31 Anacor Pharmaceuticals, Inc. Boron containing small molecules
US8979820B2 (en) 2009-10-09 2015-03-17 Cynthia S. Bailey Method and apparatus for improving the appearance of nails affected by onychomycosis through the topical application of an aqueous solution containing boric acid and camphor or other terpenes
US9346834B2 (en) 2009-10-20 2016-05-24 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
WO2011060196A1 (en) * 2009-11-11 2011-05-19 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US8716478B2 (en) 2010-01-27 2014-05-06 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US8623911B2 (en) 2010-03-19 2014-01-07 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agent
SG184268A1 (en) * 2010-04-07 2012-10-30 Glaxosmithkline Llc Process for preparing benzoxaboroles
BR112013005426B1 (pt) * 2010-09-07 2021-08-24 Anacor Pharmaceuticals, Inc Composto, composição, combinação, e, formulação farmacêutica
WO2013025975A1 (en) * 2011-08-17 2013-02-21 Glaxosmithkline Llc Combination treatments for hepatitis c
US9162999B2 (en) 2011-09-28 2015-10-20 Wisconsin Alumni Research Foundation Catalytic conversion of cellulose to fuels and chemicals using boronic acids
AR088668A1 (es) 2011-11-21 2014-06-25 Lilly Co Eli Moleculas pequeñas que contienen boro
AR088669A1 (es) 2011-11-21 2014-06-25 Lilly Co Eli Derivados de dihidrodibenzo[c][1,2]oxaborol y dihidroisoxazol utiles para el control de ectoparasitos
CN104136032B (zh) * 2011-12-22 2018-11-13 盟科医药技术公司 可用于抗菌治疗的三环类硼化合物
WO2013154759A1 (en) 2012-04-14 2013-10-17 Anacor Pharmaceuticals, Inc. Benzoxaborole compounds and uses thereof
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US9585396B2 (en) 2013-01-30 2017-03-07 Agrofresh Inc. Volatile applications against pathogens
US8669207B1 (en) 2013-01-30 2014-03-11 Dow Agrosciences, Llc. Compounds and compositions
ES2636962T3 (es) 2013-01-30 2017-10-10 Agrofresh Inc. Uso de benzoxaboroles como agentes antimicrobianos volátiles en carnes, plantas o partes de plantas
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
US9433680B2 (en) 2013-01-31 2016-09-06 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US9446131B2 (en) 2013-01-31 2016-09-20 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US8778365B1 (en) 2013-01-31 2014-07-15 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US9452173B2 (en) 2013-01-31 2016-09-27 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
WO2014121124A1 (en) 2013-02-01 2014-08-07 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
AU2014202928B1 (en) * 2013-06-05 2014-09-11 Agrofresh Inc. Compounds and compositions
KR101636431B1 (ko) * 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
KR102093783B1 (ko) * 2013-08-09 2020-03-26 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 트리시클릭 벤족사보롤 화합물 및 이의 용도
EA038093B1 (ru) * 2013-12-20 2021-07-05 Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед Способ лечения заболевания, вызванного инфекцией комплекса mycobacterium tuberculosis, с использованием (s)-(3-хлор-7,8-дигидро-2h-1,6,9-триокса-9a-борабензо[cd]азулен-2-ил)метанамина или его фармацевтически приемлемой соли
WO2015121442A1 (en) * 2014-02-17 2015-08-20 Syngenta Participations Ag Microbiocidally active benzoxaboroles
ES2732465T3 (es) 2014-07-01 2019-11-22 Daiichi Sankyo Co Ltd Benzoxaboroles tricíclicos como agentes antibacterianos
WO2016069955A1 (en) * 2014-10-29 2016-05-06 Wisconsin Alumni Research Foundation Boronic acid inhibitors of hiv protease
MA41494B1 (fr) * 2015-02-12 2020-10-28 Glaxosmithkline Ip No 2 Ltd Composés benzoxaborole substitués en position 4 et utilisations associées
CA2981773C (en) * 2015-04-09 2022-03-15 The Penn State Research Foundation Synergistic benzoxaborole-containing anti-fungicidal composition
US10160867B2 (en) * 2015-08-06 2018-12-25 The Penn State Research Foundation Benzoxaborole-containing coating resistant to cellulose-supportable fungus
US10874679B2 (en) 2016-03-02 2020-12-29 Bill & Melinda Gates Foundation Boron-containing small molecules
EP3423159A4 (en) 2016-03-02 2019-11-06 Anacor Pharmaceuticals, Inc. BORN SMALL MOLECULES
CN113563368A (zh) 2016-03-02 2021-10-29 比尔及梅琳达盖茨基金会 含硼小分子
NZ745681A (en) 2016-03-07 2022-05-27 Agrofresh Inc Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
EP3455227A1 (en) 2016-05-12 2019-03-20 Anacor Pharmaceuticals, Inc Oxaborole esters and uses thereof
US10961261B2 (en) 2017-03-01 2021-03-30 Anacor Pharmaceuticals, Inc. Oxaborole analogs and uses thereof
CN107090000B (zh) * 2017-04-27 2019-07-12 上海交通大学 一种苯并硼唑7位脂肪酸的衍生物及其制备与用途
FI3639005T3 (fi) 2017-06-13 2024-07-25 Veterinary Diagnostics Inst Inc Menetelmä verinäytteiden uuttamiseksi kuivatuista veripisaroista
CA3120974A1 (en) * 2017-11-30 2019-06-06 Boragen, Inc. Combinatorial compositions of benzoxaboroles and biologic agents
US11834466B2 (en) 2017-11-30 2023-12-05 5Metis, Inc. Benzoxaborole compounds and formulations thereof
CA3148168A1 (en) 2018-08-18 2020-02-27 Chun Yu Liu Solid forms of substituted benzoxaborole and compositions thereof
WO2020051575A1 (en) * 2018-09-07 2020-03-12 Boragen, Inc. Boron containing compounds and their uses
US11058695B2 (en) * 2019-11-08 2021-07-13 Myongji University Industry And Academia Cooperation Foundation Inhibitor of carbapenem-hydrolyzing class D beta-lactamases
WO2022043936A1 (en) 2020-08-31 2022-03-03 Pfizer Inc. Methods of protecting rna
KR20250026145A (ko) * 2022-06-23 2025-02-25 상하이 미큐알엑스 파마슈티컬 컴퍼니 리미티드 비결핵성 마이코박테리움 감염 치료에서의 붕소 화합물의 방법 및 용도 및 상기 감염의 치료를 위한 제약 조성물
CN119233977A (zh) * 2022-06-23 2024-12-31 上海盟科药业股份有限公司 硼化合物的前药及其在治疗细菌感染中的用途

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2260336A (en) * 1939-10-16 1941-10-28 Dow Chemical Co Method of preparation of organic borates
GB1396904A (en) * 1972-08-11 1975-06-11 Ici Ltd Method for the control of micro-organisms
US5962498A (en) * 1986-06-11 1999-10-05 Procyon Pharmaceuticals, Inc. Protein kinase C modulators. C. indolactam structural-types with anti-inflammatory activity
US4919934A (en) 1989-03-02 1990-04-24 Richardson-Vicks Inc. Cosmetic sticks
US5594151A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexing reagents derived from aminosalicylic acid
GB9411587D0 (en) * 1994-06-09 1994-08-03 Zeneca Ltd Compound, composition and use
US6083903A (en) * 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US5831046A (en) * 1996-08-05 1998-11-03 Prolinx, Incorporated Boronic acid-contaning nucleic acid monomers
US6306628B1 (en) * 1999-08-25 2001-10-23 Ambergen, Incorporated Methods for the detection, analysis and isolation of Nascent proteins
AU7995300A (en) * 1999-10-05 2001-05-10 Bethesda Pharmaceuticals, Inc. Dithiolane derivatives
WO2002006316A2 (en) * 2000-07-14 2002-01-24 Zycos, Inc. Alpha-msh related compounds and methods of use
US6537733B2 (en) * 2001-02-23 2003-03-25 Applied Materials, Inc. Method of depositing low dielectric constant silicon carbide layers
GB0117645D0 (en) * 2001-07-19 2001-09-12 Isis Innovation Therapeutic stratergies for prevention and treatment of alzheimers disease
DE10143979A1 (de) 2001-09-07 2003-03-27 Clariant Gmbh Verfahren zur Herstellung von Bisallylboranen und nicht-aromatischen Boronsäuren
JPWO2003033002A1 (ja) * 2001-10-11 2005-02-03 御子柴 克彦 細胞内カルシウム濃度上昇抑制剤
JP4138662B2 (ja) 2002-01-10 2008-08-27 ザ・ペンシルバニア・ステイト・リサーチ・フアウンデイシヨン アルキルジアリールボリネートおよび錯化ジアリールボロン酸を調製するための方法。
JP2005538953A (ja) * 2002-05-28 2005-12-22 3−ディメンショナル ファーマシューティカルズ, インコーポレイテッド 新規チオフェンアミジン、それらの組成物、および補体媒介疾患および病気を治療する方法
CA2529792A1 (en) 2003-06-16 2005-02-17 Anacor Pharmaceuticals, Inc. Hydrolytically-resistant boron-containing therapeutics and methods of use
EP2335722B1 (en) * 2004-05-12 2019-03-13 The Brigham and Women's Hospital, Inc. Use of gelsolin to treat infections
US7767657B2 (en) * 2005-02-16 2010-08-03 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
SI2343304T1 (sl) * 2005-02-16 2015-08-31 Anacor Pharmaceuticals, Inc. Biocidne boroftalidne spojine
BRPI0708051A2 (pt) 2006-02-16 2011-05-17 Anacor Pharmaceuticals Inc moléculas pequenas contendo boro como agentes antiflamatórios
US20070286822A1 (en) * 2006-06-12 2007-12-13 Anacor Pharmaceuticals Inc. Compounds for the Treatment of Periodontal Disease
MX2008015918A (es) 2006-06-12 2009-01-14 Anacor Pharmaceuticals Inc Compuestos para el tratamiento de enfermedad periodontal.
DE102006038471A1 (de) 2006-08-17 2008-04-10 Wala-Heilmittel Gmbh Platanencreme, Verfahren zu ihrer Herstellung und Verwendung
JO3396B1 (ar) * 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
EP2285384A4 (en) * 2008-05-12 2012-04-25 Anacor Pharmaceuticals Inc BORN SMALL MOLECULES

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12482208B2 (en) 2023-05-30 2025-11-25 Snap Inc. Mirroring 3D assets for virtual experiences

Also Published As

Publication number Publication date
CA2692135C (en) 2017-01-24
MA31675B1 (fr) 2010-09-01
MX347688B (es) 2017-05-09
WO2008157726A1 (en) 2008-12-24
BRPI0813450A2 (pt) 2014-12-30
EA020530B1 (ru) 2014-11-28
CN101772302A (zh) 2010-07-07
US20150133402A1 (en) 2015-05-14
KR20160049025A (ko) 2016-05-04
NZ582706A (en) 2012-07-27
AU2008265630A1 (en) 2008-12-24
CL2008001855A1 (es) 2009-05-29
US10533021B2 (en) 2020-01-14
CA2692135A1 (en) 2008-12-24
DOP2009000281A (es) 2010-07-31
SG182219A1 (en) 2012-07-30
EP2164331A4 (en) 2011-09-07
ES2655299T3 (es) 2018-02-19
US20100292504A1 (en) 2010-11-18
ZA201104573B (en) 2014-03-26
US20180016285A1 (en) 2018-01-18
JP5530923B2 (ja) 2014-06-25
EP2164331A1 (en) 2010-03-24
KR20100051615A (ko) 2010-05-17
KR101685656B1 (ko) 2016-12-12
JP2016040275A (ja) 2016-03-24
JP2014148531A (ja) 2014-08-21
DK2164331T3 (da) 2018-01-29
US9796735B2 (en) 2017-10-24
JP6570391B2 (ja) 2019-09-04
IL202379A0 (en) 2010-06-30
AU2008265630B2 (en) 2013-06-20
IL202379A (en) 2016-02-29
US20090227541A1 (en) 2009-09-10
PE20090840A1 (es) 2009-07-08
MY162692A (en) 2017-07-14
BRPI0813450B1 (pt) 2019-05-07
US7816344B2 (en) 2010-10-19
CR11224A (es) 2010-06-28
EA200901617A1 (ru) 2010-06-30
KR20150100945A (ko) 2015-09-02
EP2164331B1 (en) 2017-11-29
NO2164331T3 (enExample) 2018-04-28
CO6251209A2 (es) 2011-02-21
CN104017008A (zh) 2014-09-03
ZA200909003B (en) 2022-03-30
CN101772302B (zh) 2014-05-07
JP2010530881A (ja) 2010-09-16
AR067105A1 (es) 2009-09-30
US8895534B2 (en) 2014-11-25
BRPI0813450B8 (pt) 2021-05-25
KR101578351B1 (ko) 2015-12-17
UY31171A1 (es) 2009-04-30
JO3396B1 (ar) 2019-10-20

Similar Documents

Publication Publication Date Title
TW200911822A (en) Boron-containing small molecules
JP6491294B2 (ja) 細菌感染治療用のベンゾオキサボロール誘導体
CN116370479B (zh) 化合物atv014在制备用于治疗新冠病毒感染的产品中的用途
EP2444411B1 (en) Tripeptide boronic acid or boronic ester, preparative method and use thereof
US11905276B2 (en) Bicyclic compound that acts as CRBN protein regulator
CN116969957A (zh) 一种吲唑类化合物及其制备方法与应用
KR20060127906A (ko) 4'-치환된 카보버와 아바카비어 유도체 및 hiv와 hcv항바이러스 활성을 갖는 관련 화합물
WO2019096241A1 (zh) 抗HBV的四氢异噁唑并[4,3-c]吡啶类化合物
KR20030063113A (ko) 펩티드 데포르밀라제 저해제
JPH03188088A (ja) 新規リゾホスファチジルセリン
WO2025235516A1 (en) Development of lysine-specific demethylase 1 (lsd1) inhibitors as anti-cancer reagents
CN106518886A (zh) 制备手性3‑芳基‑3‑羟甲基‑2‑吲哚酮化合物
Sozanschi Benzyltetrahydroisoquinoline and bis-benzyltetrahydroisoquinoline alkaloids as anti-parasitic agents
CN121399119A (en) Integrin ligand and its use
HK40086425A (zh) 秋水仙碱衍生物的制备方法及其用途
JPS6219598A (ja) 2,3,2′,3′−テトラ−O−アルキル−α,α−トレハロ−ス誘導体
HK1141681B (en) Boron-containing small molecules
HK1242627B (zh) 治疗丝状病毒科病毒感染的方法