CO6251209A2 - Esteres ciclicos de boro y composiciones que los contienen - Google Patents

Esteres ciclicos de boro y composiciones que los contienen

Info

Publication number
CO6251209A2
CO6251209A2 CO09145296A CO09145296A CO6251209A2 CO 6251209 A2 CO6251209 A2 CO 6251209A2 CO 09145296 A CO09145296 A CO 09145296A CO 09145296 A CO09145296 A CO 09145296A CO 6251209 A2 CO6251209 A2 CO 6251209A2
Authority
CO
Colombia
Prior art keywords
proviso
unsubstituted
substituted
compositions containing
compounds
Prior art date
Application number
CO09145296A
Other languages
English (en)
Spanish (es)
Inventor
Stephen Baker
Rashmi Sharma
Vincent Hernandez
James Nieman
Tsutoma Akama
Yong-Kang Zhang
Jacob J Plattner
Michael Richard Alley
Rajesshwar Singh
Fernando Rock
James Phillips
Ming Ha
Xiaosong Lu
Original Assignee
Anacor Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40156702&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6251209(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Anacor Pharmaceuticals Inc filed Critical Anacor Pharmaceuticals Inc
Publication of CO6251209A2 publication Critical patent/CO6251209A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CO09145296A 2007-06-20 2009-12-18 Esteres ciclicos de boro y composiciones que los contienen CO6251209A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94529407P 2007-06-20 2007-06-20
US4117808P 2008-03-31 2008-03-31

Publications (1)

Publication Number Publication Date
CO6251209A2 true CO6251209A2 (es) 2011-02-21

Family

ID=40156702

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09145296A CO6251209A2 (es) 2007-06-20 2009-12-18 Esteres ciclicos de boro y composiciones que los contienen

Country Status (29)

Country Link
US (4) US7816344B2 (enExample)
EP (1) EP2164331B1 (enExample)
JP (3) JP5530923B2 (enExample)
KR (3) KR20150100945A (enExample)
CN (2) CN104017008A (enExample)
AR (1) AR067105A1 (enExample)
AU (1) AU2008265630B2 (enExample)
BR (1) BRPI0813450B8 (enExample)
CA (1) CA2692135C (enExample)
CL (1) CL2008001855A1 (enExample)
CO (1) CO6251209A2 (enExample)
CR (1) CR11224A (enExample)
DK (1) DK2164331T3 (enExample)
DO (1) DOP2009000281A (enExample)
EA (1) EA020530B1 (enExample)
ES (1) ES2655299T3 (enExample)
IL (1) IL202379A (enExample)
JO (1) JO3396B1 (enExample)
MA (1) MA31675B1 (enExample)
MX (1) MX347688B (enExample)
MY (1) MY162692A (enExample)
NO (1) NO2164331T3 (enExample)
NZ (1) NZ582706A (enExample)
PE (1) PE20090840A1 (enExample)
SG (1) SG182219A1 (enExample)
TW (1) TW200911822A (enExample)
UY (1) UY31171A1 (enExample)
WO (1) WO2008157726A1 (enExample)
ZA (2) ZA200909003B (enExample)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2872962T3 (es) * 2005-02-16 2021-11-03 Anacor Pharmaceuticals Inc Boronoftalidas para uso terapéutico
US7767657B2 (en) 2005-02-16 2010-08-03 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
RU2642628C2 (ru) 2006-02-16 2018-01-25 Анакор Фармасьютикалз, Инк. Бор-содержащие малые молекулы в качестве противовоспалительных средств
BRPI0711155A2 (pt) 2006-05-02 2011-08-23 Anacor Pharmaceuticals Inc terapêuticos contendo boro resistentes hidroliticamente e métodos de uso
JO3396B1 (ar) 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
EP3246034A1 (en) 2008-03-06 2017-11-22 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-inflammatory agents
US20100256092A1 (en) * 2008-05-12 2010-10-07 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US8461336B2 (en) 2008-09-04 2013-06-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2010027975A1 (en) * 2008-09-04 2010-03-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US9493489B2 (en) 2008-10-15 2016-11-15 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agents
SG172040A1 (en) 2008-12-17 2011-07-28 Anacor Pharmaceuticals Inc Polymorphs of (s)-3-aminomethyl-7-(3-hydroxy-propoxy)-3h-benzo[c][1,2] oxaborol-1-ol
WO2010132833A1 (en) * 2009-05-14 2010-11-18 The Regents Of The University Of Michigan Streptococcus vaccine compositions and methods of using the same
EP2458995A1 (en) * 2009-07-28 2012-06-06 Anacor Pharmaceuticals, Inc. Trisubstituted boron-containing molecules
AP4039A (en) 2009-08-14 2017-02-28 Daitao Chen Boron-containing small molecules as antiprotozoal agents
WO2011019616A1 (en) 2009-08-14 2011-02-17 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
WO2011019612A1 (en) 2009-08-14 2011-02-17 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
US20110207701A1 (en) * 2009-08-19 2011-08-25 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
US20110124597A1 (en) * 2009-09-25 2011-05-26 Anacor Pharmaceuticals, Inc. Boron containing small molecules
US8979820B2 (en) 2009-10-09 2015-03-17 Cynthia S. Bailey Method and apparatus for improving the appearance of nails affected by onychomycosis through the topical application of an aqueous solution containing boric acid and camphor or other terpenes
WO2011049971A1 (en) 2009-10-20 2011-04-28 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
US8461134B2 (en) 2009-11-11 2013-06-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US8716478B2 (en) 2010-01-27 2014-05-06 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2011116348A1 (en) 2010-03-19 2011-09-22 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agent
AU2011237681B2 (en) * 2010-04-07 2015-01-22 Glaxosmithkline Llc Process for preparing benzoxaboroles
DK2613788T3 (en) * 2010-09-07 2017-08-07 Anacor Pharmaceuticals Inc BENZOXABOROLD DERIVATIVES FOR TREATMENT OF BACTERIA INFECTIONS
WO2013025975A1 (en) * 2011-08-17 2013-02-21 Glaxosmithkline Llc Combination treatments for hepatitis c
US9162999B2 (en) 2011-09-28 2015-10-20 Wisconsin Alumni Research Foundation Catalytic conversion of cellulose to fuels and chemicals using boronic acids
AR088668A1 (es) 2011-11-21 2014-06-25 Lilly Co Eli Moleculas pequeñas que contienen boro
AR088669A1 (es) 2011-11-21 2014-06-25 Lilly Co Eli Derivados de dihidrodibenzo[c][1,2]oxaborol y dihidroisoxazol utiles para el control de ectoparasitos
US8530452B2 (en) 2011-12-22 2013-09-10 Micurx Pharmaceuticals, Inc. Tricyclic boron compounds for antimicrobial therapy
WO2013154759A1 (en) 2012-04-14 2013-10-17 Anacor Pharmaceuticals, Inc. Benzoxaborole compounds and uses thereof
US9585396B2 (en) 2013-01-30 2017-03-07 Agrofresh Inc. Volatile applications against pathogens
US8669207B1 (en) 2013-01-30 2014-03-11 Dow Agrosciences, Llc. Compounds and compositions
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
AR094666A1 (es) 2013-01-30 2015-08-19 Dow Agrosciences Llc Uso de benzoxaborolas como agentes antimicrobianos volátiles en carnes, plantas o partes de plantas
US8778365B1 (en) 2013-01-31 2014-07-15 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US9452173B2 (en) 2013-01-31 2016-09-27 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US9446131B2 (en) 2013-01-31 2016-09-20 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US9433680B2 (en) 2013-01-31 2016-09-06 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
AP2015008638A0 (en) 2013-02-01 2015-08-31 Anacor Pharmaceuticals Inc Boron-containing small molecules as antiprotozoal agents
AU2014202928B1 (en) * 2013-06-05 2014-09-11 Agrofresh Inc. Compounds and compositions
KR101636431B1 (ko) 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
US20160251380A1 (en) * 2013-08-09 2016-09-01 Glaxosmithkline Intellectual Property (No.2) Limited Tricyclic benzoxaborole compounds and uses thereof
EA038093B1 (ru) * 2013-12-20 2021-07-05 Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед Способ лечения заболевания, вызванного инфекцией комплекса mycobacterium tuberculosis, с использованием (s)-(3-хлор-7,8-дигидро-2h-1,6,9-триокса-9a-борабензо[cd]азулен-2-ил)метанамина или его фармацевтически приемлемой соли
BR112016018483A2 (pt) * 2014-02-17 2018-07-10 Syngenta Participations Ag benzoxaboróis ativos do ponto de vista microbicida
CN106459097A (zh) * 2014-07-01 2017-02-22 第三共株式会社 作为抗菌剂的三环苯并氧杂硼杂环戊烯类
US9738664B2 (en) * 2014-10-29 2017-08-22 Wisconsin Alumni Research Foundation Boronic acid inhibitors of HIV protease
MA41495A (fr) 2015-02-12 2017-12-19 Anacor Pharmaceuticals Inc Composés benzoxaborole et leurs utilisations
CA2981773C (en) 2015-04-09 2022-03-15 The Penn State Research Foundation Synergistic benzoxaborole-containing anti-fungicidal composition
WO2017024022A1 (en) * 2015-08-06 2017-02-09 The Penn State Research Foundation Benzoxaborole-containing coating resistant to cellulose-supportable fungus
CN109152932B (zh) 2016-03-02 2021-09-28 比尔及梅琳达盖茨基金会 含硼小分子
US10874679B2 (en) 2016-03-02 2020-12-29 Bill & Melinda Gates Foundation Boron-containing small molecules
US10611780B2 (en) 2016-03-02 2020-04-07 Bill And Melinda Gates Foundation Boron-containing small molecules
WO2017155879A1 (en) 2016-03-07 2017-09-14 Agrofresh Inc. Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
PE20190119A1 (es) 2016-05-12 2019-01-17 Anacor Pharmaceuticals Inc Esteres de oxaborol y sus usos
US10961261B2 (en) 2017-03-01 2021-03-30 Anacor Pharmaceuticals, Inc. Oxaborole analogs and uses thereof
CN107090000B (zh) * 2017-04-27 2019-07-12 上海交通大学 一种苯并硼唑7位脂肪酸的衍生物及其制备与用途
FI4265332T3 (fi) 2017-06-13 2025-05-21 Veterinary Diagnostics Inst Inc Järjestelmä ja menetelmä verinäytteiden stabiloimiseksi, säilyttämiseksi ja ottamiseksi talteen
US20190159457A1 (en) * 2017-11-30 2019-05-30 Boragen, Inc. Combinatorial Compositions of Benzoxaboroles and Biologic Agents
MX2020005464A (es) * 2017-11-30 2020-12-03 Boragen Inc Compuestos de benzoxaborol y formulaciones de los mismos.
EP3836938A4 (en) 2018-08-18 2022-05-11 Boragen, Inc. SOLID FORMS OF SUBSTITUTED BENZOXAZOLE AND COMPOSITIONS THEREOF
AR116305A1 (es) * 2018-09-07 2021-04-21 Boragen Inc Compuestos que contienen boro y sus usos
US11058695B2 (en) * 2019-11-08 2021-07-13 Myongji University Industry And Academia Cooperation Foundation Inhibitor of carbapenem-hydrolyzing class D beta-lactamases
WO2022043936A1 (en) 2020-08-31 2022-03-03 Pfizer Inc. Methods of protecting rna
WO2023076453A1 (en) * 2021-10-29 2023-05-04 An2 Therapeutics, Inc. Treating neuroinflammatory conditions
JP2025520237A (ja) * 2022-06-23 2025-07-03 ミクウルク ファーマシューティカルズ， インコーポレイテッド ホウ素化合物を用いて非結核性マイコバクテリア感染症を治療する方法及びその用途、並びに同じ疾患を治療するための医薬組成物
CA3239097A1 (en) 2022-06-23 2023-12-28 Shanghai Micurx Pharmaceutical Co., Ltd. Prodrugs of boron compounds and their use in treating bacterial infections
US12482208B2 (en) 2023-05-30 2025-11-25 Snap Inc. Mirroring 3D assets for virtual experiences

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2260336A (en) * 1939-10-16 1941-10-28 Dow Chemical Co Method of preparation of organic borates
GB1396904A (en) 1972-08-11 1975-06-11 Ici Ltd Method for the control of micro-organisms
US5962498A (en) * 1986-06-11 1999-10-05 Procyon Pharmaceuticals, Inc. Protein kinase C modulators. C. indolactam structural-types with anti-inflammatory activity
US4919934A (en) 1989-03-02 1990-04-24 Richardson-Vicks Inc. Cosmetic sticks
US5594151A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexing reagents derived from aminosalicylic acid
GB9411587D0 (en) * 1994-06-09 1994-08-03 Zeneca Ltd Compound, composition and use
US6083903A (en) * 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US5831046A (en) * 1996-08-05 1998-11-03 Prolinx, Incorporated Boronic acid-contaning nucleic acid monomers
US6306628B1 (en) * 1999-08-25 2001-10-23 Ambergen, Incorporated Methods for the detection, analysis and isolation of Nascent proteins
AU7995300A (en) * 1999-10-05 2001-05-10 Bethesda Pharmaceuticals, Inc. Dithiolane derivatives
WO2002006316A2 (en) * 2000-07-14 2002-01-24 Zycos, Inc. Alpha-msh related compounds and methods of use
US6537733B2 (en) * 2001-02-23 2003-03-25 Applied Materials, Inc. Method of depositing low dielectric constant silicon carbide layers
GB0117645D0 (en) * 2001-07-19 2001-09-12 Isis Innovation Therapeutic stratergies for prevention and treatment of alzheimers disease
DE10143979A1 (de) 2001-09-07 2003-03-27 Clariant Gmbh Verfahren zur Herstellung von Bisallylboranen und nicht-aromatischen Boronsäuren
US7217701B2 (en) * 2001-10-11 2007-05-15 Katsuhiko Mikoshiba Intracellular calcium concentration increase inhibitors
CN1325504C (zh) 2002-01-10 2007-07-11 宾夕法尼亚州研究基金会 制备二芳基硼酸烷基酯和络合的二芳基硼酸的方法
UA80131C2 (en) * 2002-05-28 2007-08-27 Dimensional Pharm Inc Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
CN1829521B (zh) * 2003-06-16 2011-01-26 安纳考尔医药公司 耐水解的含硼治疗剂和使用方法
CN1980694B (zh) * 2004-05-12 2012-09-26 布赖汉姆妇女医院有限公司 凝溶胶蛋白治疗感染的用途
US7767657B2 (en) 2005-02-16 2010-08-03 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
ES2872962T3 (es) * 2005-02-16 2021-11-03 Anacor Pharmaceuticals Inc Boronoftalidas para uso terapéutico
RU2642628C2 (ru) * 2006-02-16 2018-01-25 Анакор Фармасьютикалз, Инк. Бор-содержащие малые молекулы в качестве противовоспалительных средств
US20070286822A1 (en) * 2006-06-12 2007-12-13 Anacor Pharmaceuticals Inc. Compounds for the Treatment of Periodontal Disease
BRPI0713010A2 (pt) * 2006-06-12 2012-10-09 Anacor Pharmaceuticals Inc compostos para o tratamento de doença periodontal
DE102006038471A1 (de) 2006-08-17 2008-04-10 Wala-Heilmittel Gmbh Platanencreme, Verfahren zu ihrer Herstellung und Verwendung
JO3396B1 (ar) * 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
US20100256092A1 (en) * 2008-05-12 2010-10-07 Anacor Pharmaceuticals, Inc. Boron-containing small molecules

Also Published As

Publication number Publication date
US7816344B2 (en) 2010-10-19
JP5530923B2 (ja) 2014-06-25
US9796735B2 (en) 2017-10-24
CA2692135C (en) 2017-01-24
KR20160049025A (ko) 2016-05-04
US20100292504A1 (en) 2010-11-18
BRPI0813450B8 (pt) 2021-05-25
CN101772302A (zh) 2010-07-07
WO2008157726A1 (en) 2008-12-24
TW200911822A (en) 2009-03-16
MX347688B (es) 2017-05-09
EP2164331A1 (en) 2010-03-24
US10533021B2 (en) 2020-01-14
US8895534B2 (en) 2014-11-25
ES2655299T3 (es) 2018-02-19
EA200901617A1 (ru) 2010-06-30
BRPI0813450A2 (pt) 2014-12-30
EP2164331B1 (en) 2017-11-29
KR101578351B1 (ko) 2015-12-17
DK2164331T3 (da) 2018-01-29
AU2008265630B2 (en) 2013-06-20
CR11224A (es) 2010-06-28
ZA201104573B (en) 2014-03-26
US20150133402A1 (en) 2015-05-14
PE20090840A1 (es) 2009-07-08
JO3396B1 (ar) 2019-10-20
CL2008001855A1 (es) 2009-05-29
ZA200909003B (en) 2022-03-30
KR20150100945A (ko) 2015-09-02
JP2016040275A (ja) 2016-03-24
JP2010530881A (ja) 2010-09-16
CA2692135A1 (en) 2008-12-24
IL202379A (en) 2016-02-29
EA020530B1 (ru) 2014-11-28
NZ582706A (en) 2012-07-27
UY31171A1 (es) 2009-04-30
KR101685656B1 (ko) 2016-12-12
NO2164331T3 (enExample) 2018-04-28
AR067105A1 (es) 2009-09-30
BRPI0813450B1 (pt) 2019-05-07
CN104017008A (zh) 2014-09-03
US20090227541A1 (en) 2009-09-10
JP6570391B2 (ja) 2019-09-04
SG182219A1 (en) 2012-07-30
DOP2009000281A (es) 2010-07-31
US20180016285A1 (en) 2018-01-18
CN101772302B (zh) 2014-05-07
KR20100051615A (ko) 2010-05-17
MA31675B1 (fr) 2010-09-01
MY162692A (en) 2017-07-14
AU2008265630A1 (en) 2008-12-24
IL202379A0 (en) 2010-06-30
JP2014148531A (ja) 2014-08-21
EP2164331A4 (en) 2011-09-07

Similar Documents

Publication Publication Date Title
AR067105A1 (es) Moleculas pequenas que contienen boro
UY28877A1 (es) Compuestos de metil-aril o heteroaril-amida sustituida y composiciones
ES2477940T3 (es) Imidazoles condensados y composiciones que los incluyen para el tratamiento de enfermedades parasitarias tales como por ejemplo malaria
PE20170247A1 (es) Derivados de pirrolidina-2,5-diona, composiciones farmaceuticas y metodos para usar como inhibidores ido1
AR083760A1 (es) Agentes antibacterianos y composiciones farmaceuticas
AR071833A1 (es) Inhibidores de quinasas (limk2), composiciones que los comprenden y metodos para tratar o prevenir enfermedades
PE20040450A1 (es) Heteroariloxi-aril-espiro-pirimidina-2,4,6-triona n-sustituida como inhibidores de metaloproteinasa
CL2008001669A1 (es) Compuestos derivados de piperidina/piperazina inhibidora de dgat-1; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso en el tratamiento de la obesidad, dislipidemia, fibrosis hepatica y diabetes tipo ii, entre otras.
PE20181045A1 (es) Compuestos utiles como inmunomoduladores
UY28878A1 (es) Compuestos de aril-o heteroarilamida ortosustituidos y composiciones
EA201001682A1 (ru) Производные фенил- и бензодиоксинилзамещенных индазолов
AR066881A1 (es) Derivados de oxadiazol, una composicion farmaceutica que los comprende y su uso en la preparacion de medicamentos para el tratamiento de trastornos asociados con la disfuncion del glutamato.
SV2008003045A (es) Aminotetrahidropiranos como inhibidores de dipertidil, peptidasa-iv para el tratamiento o prevencion de diabetes
AR091858A1 (es) INHIBIDORES DE CISTATIONIN-g-LIASA (CSE)
PT2421879E (pt) Novos 7-deazapurina nucleósidos para utilizações terapêuticas
AR069490A1 (es) Agonistas de los receptores de glucocorticoides
AR091156A1 (es) Nucleosidos de espirooxetano de uracilo
AR072261A1 (es) Derivados piperazin-pirazolicos, composiciones farmaceuticas que los contienen y usos de los mismos como agentes anticancerigenos.
MX2012002031A (es) Moleculas pequeñas que contienen boro como agentes antiprotozoarios.
ECSP077402A (es) Derivados de 2-amido-4-feniltiazol, su preparación y su aplicación en terapéutica
ECSP088457A (es) Compuestos de benzamida útiles como inhibidores de la histona deacetilasa
AR085327A1 (es) Inhibidores del virus de la hepatitis c
PE20250739A1 (es) Agonistas inversos del pparg y usos de los mismos
CO6150149A2 (es) Compuestos azabiciclicos como inhibidfores de la recaptacion de monoaminas
MA39043A1 (fr) Dérivés de purine substitués en positions 2 et 6, et leur utilisation dans le traitement des désordres prolifératifs

Legal Events

Date Code Title Description
FC Application refused