TW200716580A - (5Z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5H)-one - Google Patents
(5Z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5H)-oneInfo
- Publication number
- TW200716580A TW200716580A TW095119940A TW95119940A TW200716580A TW 200716580 A TW200716580 A TW 200716580A TW 095119940 A TW095119940 A TW 095119940A TW 95119940 A TW95119940 A TW 95119940A TW 200716580 A TW200716580 A TW 200716580A
- Authority
- TW
- Taiwan
- Prior art keywords
- quinoxalinylmethylidene
- thiazol
- dichlorophenyl
- compound
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68867105P | 2005-06-08 | 2005-06-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200716580A true TW200716580A (en) | 2007-05-01 |
Family
ID=37532819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW095119940A TW200716580A (en) | 2005-06-08 | 2006-06-06 | (5Z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5H)-one |
Country Status (21)
Country | Link |
---|---|
US (1) | US7674792B2 (zh) |
EP (1) | EP1888531A4 (zh) |
JP (1) | JP2008543770A (zh) |
KR (1) | KR20080014017A (zh) |
CN (1) | CN101193863A (zh) |
AP (1) | AP2007004241A0 (zh) |
AR (1) | AR054059A1 (zh) |
AU (1) | AU2006258032A1 (zh) |
BR (1) | BRPI0611096A2 (zh) |
CA (1) | CA2611480A1 (zh) |
EA (1) | EA200702457A1 (zh) |
IL (1) | IL187423A0 (zh) |
MA (1) | MA29567B1 (zh) |
MX (1) | MX2007015572A (zh) |
NO (1) | NO20080130L (zh) |
NZ (1) | NZ563421A (zh) |
PE (1) | PE20070083A1 (zh) |
TW (1) | TW200716580A (zh) |
UY (1) | UY29581A1 (zh) |
WO (1) | WO2006135712A2 (zh) |
ZA (1) | ZA200709813B (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080194466A1 (en) * | 2005-06-08 | 2008-08-14 | Duffy Kevin J | (5Z)-5-(6-Quinoxalinylmethylidene)-2-[(2,4,6-Trichlorophenyl)Amino]-1,3-Thiazol-4(5H)-One |
US20100286041A1 (en) * | 2007-03-22 | 2010-11-11 | Smithkline Beecham Corporation | (5z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5h)-one |
WO2008150837A1 (en) * | 2007-06-01 | 2008-12-11 | Smithkline Beecham Corporation | Methods of treatment |
Family Cites Families (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5545648A (en) | 1978-09-29 | 1980-03-31 | Teikoku Hormone Mfg Co Ltd | 2-formyldibenzazepin derivative and its preparation |
US5089516A (en) * | 1987-03-11 | 1992-02-18 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | 1-phenyl-3,5-pyrazolidinedione hydroxystyrene compounds which have tyrosine kinase inhibiting activity |
WO1988007035A1 (en) * | 1987-03-11 | 1988-09-22 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Hydroxystyrene derivatives |
US5202341A (en) * | 1987-03-11 | 1993-04-13 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Hydroxystyrene compounds having tyrosine kinase inhibiting activity |
JPH0197926A (ja) | 1987-10-09 | 1989-04-17 | Idemitsu Kosan Co Ltd | 有機非線型光学材料 |
DD270072A1 (de) | 1988-03-14 | 1989-07-19 | Univ Halle Wittenberg | Verfahren zur herstellung von 5-aryliden- hoch 2-thiazolin-4-onen |
US5306822A (en) | 1988-05-25 | 1994-04-26 | Warner-Lambert Company | Arylmethylenyl derivatives of oxazolidinone |
US5145753A (en) * | 1989-09-12 | 1992-09-08 | Mitsubishi Jukogyo Kabushiki Kaisha | Solid electrolyte fuel cell |
US5053420A (en) | 1989-10-13 | 1991-10-01 | Pershadsingh Harrihar A | Thiazolidine derivatives for the treatment of hypertension |
GB9004483D0 (en) * | 1990-02-28 | 1990-04-25 | Erba Carlo Spa | New aryl-and heteroarylethenylene derivatives and process for their preparation |
US5143928A (en) * | 1990-03-27 | 1992-09-01 | Warner-Lambert Company | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents |
JPH052200A (ja) | 1990-09-28 | 1993-01-08 | Toshiba Corp | 有機非線形光学材料 |
DE69318863T2 (de) | 1992-02-03 | 1998-09-24 | Fuji Photo Film Co Ltd | Verfahren zur Dispergierung eines Farbstoffs und ein Farbstoff enthaltendes photographisches Silberhalogenidmaterial |
JP2835246B2 (ja) | 1992-06-02 | 1998-12-14 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料 |
EP0915090A1 (en) * | 1992-09-10 | 1999-05-12 | Eli Lilly And Company | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease |
DE69331891T2 (de) * | 1992-09-11 | 2002-10-31 | Agfa Gevaert Nv | Photographisches Element,das einen Filterfarbstoff enthält, für Schnellverarbeitungs-Verwendungen |
DE69333314D1 (de) * | 1992-09-11 | 2004-01-08 | Agfa Gevaert Nv | Photographisches Element,das einen Filterfarbstoff enthält, für Schnellverarbeitungs-Verwendungen |
JPH06128234A (ja) | 1992-10-19 | 1994-05-10 | Fuji Photo Film Co Ltd | 不斉炭素原子を有する化合物およびそれからなる非線形光学材料 |
US5554767A (en) * | 1993-05-21 | 1996-09-10 | Warner-Lambert Company | Alpha-mercaptoacrylic acid derivatives having calpain inhibitory activity |
US6251928B1 (en) * | 1994-03-16 | 2001-06-26 | Eli Lilly And Company | Treatment of alzheimer's disease employing inhibitors of cathepsin D |
EP0687573A1 (en) * | 1994-06-13 | 1995-12-20 | Agfa-Gevaert N.V. | Dye donor element for use in a thermal dye transfer method |
JP3871354B2 (ja) * | 1994-07-29 | 2007-01-24 | 株式会社フジモト・コーポレーション | 新規な2−(n−シアノイミノ)チアゾリジン−4−オン誘導体 |
JPH08109176A (ja) | 1994-10-07 | 1996-04-30 | Torii Yakuhin Kk | イソローダニンn酢酸誘導体 |
IL117208A0 (en) | 1995-02-23 | 1996-06-18 | Nissan Chemical Ind Ltd | Indole type thiazolidines |
US5618835A (en) * | 1996-02-01 | 1997-04-08 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
JPH09255669A (ja) | 1996-03-22 | 1997-09-30 | Hisamitsu Pharmaceut Co Inc | 新規なベンジリデン誘導体 |
US5958957A (en) * | 1996-04-19 | 1999-09-28 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
US6632947B2 (en) * | 1997-02-18 | 2003-10-14 | Smithkline Beecham Plc | Process for the preparation of substituted thiazolidinedione |
US6011031A (en) * | 1997-05-30 | 2000-01-04 | Dr. Reddy's Research Foundation | Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them |
WO1999059586A1 (en) | 1998-05-19 | 1999-11-25 | Regents Of The University Of California | Thiazolidine and oxazolidine derivatives for the treatment of acute myocardial infarction and inhibition of cardiomyocyte apoptosis |
AU6330999A (en) | 1998-09-30 | 2000-04-17 | Roche Diagnostics Gmbh | Rhodanine derivatives for the treatment and prevention of metabolic bone disorders |
US6221613B1 (en) * | 1998-12-31 | 2001-04-24 | Synaptic Pharmaceutical Corporation | DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof |
US6689491B1 (en) * | 1999-02-08 | 2004-02-10 | Fuji Photo Film Co., Ltd. | Luminescent device material, luminescent device using the same, and amine compound |
JP2001072592A (ja) * | 1999-07-01 | 2001-03-21 | Kyowa Hakko Kogyo Co Ltd | テロメラーゼ阻害剤 |
EP1109808A1 (en) * | 1999-07-01 | 2001-06-27 | Geron Corporation | Substituted indole compounds and their use for the treatment of cancer |
US6720345B1 (en) * | 1999-11-05 | 2004-04-13 | Smithkline Beecham Corporation | Semicarbazone derivatives and their use as thrombopoietin mimetics |
US7005288B1 (en) * | 1999-11-10 | 2006-02-28 | Novozymes A/S | Fungamyl-like alpha-amylase variants |
JP2001348520A (ja) * | 2000-04-03 | 2001-12-18 | Fuji Photo Film Co Ltd | メチン化合物、固体微粒子分散物、インクジェット用記録液、およびインクジェット記録方法 |
CY2010012I2 (el) | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
EP1299362A4 (en) | 2000-07-05 | 2004-11-03 | Synaptic Pharma Corp | SELECTIVE RECEPTOR ANTAGONISTS OF MELANINE CONCENTRATING HORMON-1 (MCH1) AND THEIR USE |
US6410734B1 (en) * | 2000-07-17 | 2002-06-25 | Wyeth | 2-substituted thiazolidinones as beta-3 adrenergic receptor agonists |
DE10115227A1 (de) * | 2001-03-28 | 2002-12-19 | Bayer Ag | Optischer Datenträger enthaltend in der Informationsschicht eine lichtabsorbierende Verbindung mit mehreren chromophoren Zentren |
US6452014B1 (en) * | 2000-12-22 | 2002-09-17 | Geron Corporation | Telomerase inhibitors and methods of their use |
EP1372654A4 (en) * | 2001-04-06 | 2007-10-03 | Smithkline Beecham Corp | QUINOLINE INHIBITORS OF HYAK1 AND HYAK3 KINASES |
TW200304375A (en) * | 2001-12-06 | 2003-10-01 | Maxia Pharmaceuticals Inc | 2-Substituted thiazolidinone and oxazolidinone derivatives for the inhibition of phosphatases and the treatment of cancer |
US20050019825A9 (en) * | 2002-03-15 | 2005-01-27 | Qing Dong | Common ligand mimics: pseudothiohydantoins |
EP1556379A4 (en) * | 2002-10-16 | 2007-06-13 | Smithkline Beecham Corp | CHEMICAL COMPOUNDS |
AU2003298693B2 (en) * | 2002-11-22 | 2010-09-30 | Smithkline Beecham Corporation | Novel chemical compounds |
US7645421B2 (en) * | 2003-06-20 | 2010-01-12 | Roche Diagnostics Operations, Inc. | System and method for coding information on a biosensor test strip |
CA2531140C (en) * | 2003-07-28 | 2013-06-18 | Applied Research Systems Ars Holding N.V. | 2-imino-4-(thio) oxo-5-polycyclovinylazolines for use as pi3 kinase inhibitors |
EP1654380A4 (en) * | 2003-08-14 | 2009-09-09 | Insight Biopharmaceuticals Ltd | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR MODULATING HEPARANASE ACTIVATION AND USES THEREOF |
US20090270456A1 (en) | 2004-01-09 | 2009-10-29 | Masaichi Hasegawa | Novel chemical compounds |
JP2007520558A (ja) | 2004-02-04 | 2007-07-26 | スミスクライン・ビーチャム・コーポレイション | キナーゼ阻害剤として有用なピリミジノン化合物 |
WO2005082363A1 (en) | 2004-02-20 | 2005-09-09 | Board Of Regents, The University Of Texas System | Thiazolone compounds for treatment of cancer |
JP2007523957A (ja) | 2004-02-25 | 2007-08-23 | スミスクライン・ビーチャム・コーポレイション | 新規化学化合物 |
CN1984909A (zh) * | 2004-07-01 | 2007-06-20 | 霍夫曼-拉罗奇有限公司 | 噻唑啉酮未取代的喹啉 |
KR100856363B1 (ko) * | 2004-07-01 | 2008-09-04 | 에프. 호프만-라 로슈 아게 | Cdk1 항증식 활성을 갖는 퀴놀린 티아졸리논 |
US7253285B2 (en) * | 2004-09-17 | 2007-08-07 | Hoffmann-La Roche Inc. | Thiazolinone 4-monosubstituted quinolines |
TW200716132A (en) | 2005-05-03 | 2007-05-01 | Smithkline Beecham Corp | Novel chemical compounds |
US20090203692A1 (en) | 2005-05-23 | 2009-08-13 | Smithkline Beecham Corporation | Novel chemical compounds |
US20080194466A1 (en) | 2005-06-08 | 2008-08-14 | Duffy Kevin J | (5Z)-5-(6-Quinoxalinylmethylidene)-2-[(2,4,6-Trichlorophenyl)Amino]-1,3-Thiazol-4(5H)-One |
-
2006
- 2006-06-06 PE PE2006000617A patent/PE20070083A1/es not_active Application Discontinuation
- 2006-06-06 TW TW095119940A patent/TW200716580A/zh unknown
- 2006-06-07 UY UY29581A patent/UY29581A1/es unknown
- 2006-06-07 AR ARP060102377A patent/AR054059A1/es not_active Application Discontinuation
- 2006-06-08 EP EP06784680A patent/EP1888531A4/en not_active Withdrawn
- 2006-06-08 KR KR1020077028716A patent/KR20080014017A/ko not_active Application Discontinuation
- 2006-06-08 CN CNA2006800206173A patent/CN101193863A/zh active Pending
- 2006-06-08 AP AP2007004241A patent/AP2007004241A0/xx unknown
- 2006-06-08 BR BRPI0611096-7A patent/BRPI0611096A2/pt not_active IP Right Cessation
- 2006-06-08 NZ NZ563421A patent/NZ563421A/en not_active IP Right Cessation
- 2006-06-08 WO PCT/US2006/022385 patent/WO2006135712A2/en active Application Filing
- 2006-06-08 EA EA200702457A patent/EA200702457A1/ru unknown
- 2006-06-08 CA CA002611480A patent/CA2611480A1/en not_active Abandoned
- 2006-06-08 JP JP2008515941A patent/JP2008543770A/ja not_active Withdrawn
- 2006-06-08 AU AU2006258032A patent/AU2006258032A1/en not_active Abandoned
- 2006-06-08 MX MX2007015572A patent/MX2007015572A/es unknown
-
2007
- 2007-03-22 US US11/726,741 patent/US7674792B2/en not_active Expired - Fee Related
- 2007-11-14 ZA ZA200709813A patent/ZA200709813B/xx unknown
- 2007-11-15 IL IL187423A patent/IL187423A0/en unknown
- 2007-12-26 MA MA30514A patent/MA29567B1/fr unknown
-
2008
- 2008-01-08 NO NO20080130A patent/NO20080130L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NZ563421A (en) | 2010-07-30 |
CN101193863A (zh) | 2008-06-04 |
JP2008543770A (ja) | 2008-12-04 |
MX2007015572A (es) | 2008-02-25 |
KR20080014017A (ko) | 2008-02-13 |
US20070179144A1 (en) | 2007-08-02 |
PE20070083A1 (es) | 2007-01-27 |
NO20080130L (no) | 2008-01-08 |
WO2006135712A3 (en) | 2007-06-28 |
EP1888531A2 (en) | 2008-02-20 |
CA2611480A1 (en) | 2006-12-21 |
ZA200709813B (en) | 2008-09-25 |
MA29567B1 (fr) | 2008-06-02 |
EA200702457A1 (ru) | 2008-04-28 |
IL187423A0 (en) | 2008-02-09 |
AU2006258032A1 (en) | 2006-12-21 |
WO2006135712A2 (en) | 2006-12-21 |
UY29581A1 (es) | 2006-11-30 |
US7674792B2 (en) | 2010-03-09 |
EP1888531A4 (en) | 2009-06-17 |
AR054059A1 (es) | 2007-05-30 |
BRPI0611096A2 (pt) | 2010-12-21 |
AP2007004241A0 (en) | 2007-12-31 |
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