TW200413377A - Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors - Google Patents

Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors Download PDF

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Publication number
TW200413377A
TW200413377A TW092124349A TW92124349A TW200413377A TW 200413377 A TW200413377 A TW 200413377A TW 092124349 A TW092124349 A TW 092124349A TW 92124349 A TW92124349 A TW 92124349A TW 200413377 A TW200413377 A TW 200413377A
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TW
Taiwan
Prior art keywords
group
compound
patent application
doc
cycloalkyl
Prior art date
Application number
TW092124349A
Other languages
English (en)
Chinese (zh)
Inventor
Timothy J Guzi
Kamil Paruch
Michael P Dwyer
Ronald J Doll
Viyyoor Moopil Girijavallabhan
W Dillard Lawrence
D Tran Vinh
Min He Zhen
Anthony James Ray
Park Haengsoon
Original Assignee
Schering Corp
Pharmacopeia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp, Pharmacopeia Inc filed Critical Schering Corp
Publication of TW200413377A publication Critical patent/TW200413377A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW092124349A 2002-09-04 2003-09-03 Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors TW200413377A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40803002P 2002-09-04 2002-09-04

Publications (1)

Publication Number Publication Date
TW200413377A true TW200413377A (en) 2004-08-01

Family

ID=31978549

Family Applications (1)

Application Number Title Priority Date Filing Date
TW092124349A TW200413377A (en) 2002-09-04 2003-09-03 Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors

Country Status (18)

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US (2) US7078525B2 (US20030162802A1-20030828-C00221.png)
EP (1) EP1534709B1 (US20030162802A1-20030828-C00221.png)
JP (2) JP2006501260A (US20030162802A1-20030828-C00221.png)
KR (1) KR20050058507A (US20030162802A1-20030828-C00221.png)
CN (1) CN1310918C (US20030162802A1-20030828-C00221.png)
AR (1) AR041134A1 (US20030162802A1-20030828-C00221.png)
AT (1) ATE364608T1 (US20030162802A1-20030828-C00221.png)
CA (1) CA2497444C (US20030162802A1-20030828-C00221.png)
DE (1) DE60314427T2 (US20030162802A1-20030828-C00221.png)
ES (1) ES2285164T3 (US20030162802A1-20030828-C00221.png)
HK (1) HK1071570A1 (US20030162802A1-20030828-C00221.png)
MX (1) MXPA05002573A (US20030162802A1-20030828-C00221.png)
MY (1) MY139336A (US20030162802A1-20030828-C00221.png)
NZ (1) NZ539162A (US20030162802A1-20030828-C00221.png)
PE (1) PE20041076A1 (US20030162802A1-20030828-C00221.png)
TW (1) TW200413377A (US20030162802A1-20030828-C00221.png)
WO (1) WO2004022559A1 (US20030162802A1-20030828-C00221.png)
ZA (1) ZA200501851B (US20030162802A1-20030828-C00221.png)

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Also Published As

Publication number Publication date
EP1534709A1 (en) 2005-06-01
AU2003268357A1 (en) 2004-03-29
MXPA05002573A (es) 2005-09-08
JP2010132704A (ja) 2010-06-17
US7078525B2 (en) 2006-07-18
CA2497444A1 (en) 2004-03-18
JP2006501260A (ja) 2006-01-12
AR041134A1 (es) 2005-05-04
US20060235025A1 (en) 2006-10-19
NZ539162A (en) 2006-07-28
DE60314427T2 (de) 2008-06-12
ES2285164T3 (es) 2007-11-16
KR20050058507A (ko) 2005-06-16
CA2497444C (en) 2010-11-30
US7470695B2 (en) 2008-12-30
ATE364608T1 (de) 2007-07-15
CN1738821A (zh) 2006-02-22
EP1534709B1 (en) 2007-06-13
CN1310918C (zh) 2007-04-18
PE20041076A1 (es) 2005-01-22
DE60314427D1 (de) 2007-07-26
ZA200501851B (en) 2005-09-08
MY139336A (en) 2009-09-30
US20040102451A1 (en) 2004-05-27
HK1071570A1 (en) 2005-07-22
WO2004022559A1 (en) 2004-03-18

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