TW200407073A - Benzanilide compound and preventing and eradiating agent for pest containing the same - Google Patents

Benzanilide compound and preventing and eradiating agent for pest containing the same Download PDF

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Publication number
TW200407073A
TW200407073A TW092123397A TW92123397A TW200407073A TW 200407073 A TW200407073 A TW 200407073A TW 092123397 A TW092123397 A TW 092123397A TW 92123397 A TW92123397 A TW 92123397A TW 200407073 A TW200407073 A TW 200407073A
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Taiwan
Prior art keywords
alkyl
group
substituted
formula
cycloalkyl
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TW092123397A
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English (en)
Inventor
Takeshi Mita
Yoshihiro Kudo
Takashi Mizukoshi
Hiroyasu Hotta
Kazushige Maeda
Takii Shinji
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Nissan Chemical Ind Ltd
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Publication of TW200407073A publication Critical patent/TW200407073A/zh

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
    • A01N37/30—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof containing the groups —CO—N< and, both being directly attached by their carbon atoms to the same carbon skeleton, e.g. H2N—NH—CO—C6H4—COOCH3; Thio-analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
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    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
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    • C07C233/75—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
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  • Plural Heterocyclic Compounds (AREA)

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200407073 玫、發明說明： 【發明所屬之技術領域】 _本發明係、關於新穎的取A N-I (甲）酿笨胺匕合物及其 ^ ’以及以該化合物做為有效成分之有害生物防止與去除 二。：本發明中’所謂「有害生物防止與去除劑」意指以 :園藝領域或畜產、衛生領域（動物藥或家庭用及業務用殺 蟲劑）中有害的節肢動物為對象之害蟲防止與去除劑。又在 X月中所明之展藥意指農藝•園藝領域中之殺蟲及滅虱 劑、殺線蟲劑、除草劑及殺菌劑。 【先前技術】 、先岫已知特疋之取代N-苯甲醯苯胺衍生物具有細皰 激素產生抑㈣〉舌性及加壓素拮抗活性等，被做為醫藥品使 (例如苓知、專利文獻i至3)。又，已知特定之取代N_苯 甲Sm苯胺衍生物具有殺蟲活性（例如參照專利文獻4至 i〇)但疋，對於本發明相關之取代N-苯（甲）醯苯胺化合物 則無任何揭示。 專利文獻1 專利文獻2 專利文獻3 專利文獻4 國際公開第98/024771號公報 國際公開第99/05 1580號公報 特開2002-249473號公報 歐洲專利申請案公開第0919542號說明 專利文獻5歐洲專利申請案公開第丨〇〇6 1 07號說明 書 專利文獻6 國際公開第01/02 1 576號公報 7 314918 200407073 專利文獻7國際公開第01/046124號公報 專利文獻8特開2001-33 55 59號公報 專利文獻9國際公開第02/062807號公報 專利文獻10國際公開第02/094765號公報 【發明内容】 [發明欲解決之問題] 由於長年使用例如殺蟲劑及殺菌劑之有害生物防止及 去除劑，近年病害蟲獲得抗藥性，先前所使用之殺蟲劑及 殺菌劑變得難以防止及去除害蟲。又’由於既存之有害生 物防止及去除劑之-部分毒性高或某些有長期殘留性因 此正擾亂著生態系。在此情況下，隨時期待著低毒性或低 殘邊性之新减有害生物防止及去除劑之開發。 [解決課題之手段] 本發明者以解決上述課題為目標經反覆深入研究之結 $，發現本發明之下述通式⑴表示之新穎取代N-苯（甲）醯 本fe化合物具有優異之有害生物防除活性，尤其顯示殺蟲 及殺蟎活性’而且對於哺乳動物、魚類及益蟲等非標的生 物在大體上無不良影響，為極有用之化合物。於是完成本 發明。 亦即本發明係關於下述[1 ]至[1 9]。 [1]種通式⑴表示之取代N-苯（甲）醯苯胺化合物戍 其鹽： 314918 8 200407073
r2：N'r3 (1) [式中 G表不包含至少i個從氧原子、硫原子及氮原子中選 出之原子且環内存在至少、！個雙鍵之5員或6員非芳香族 雜環，包含2個從氧料、硫原子及氮原子中選出之原子 之5員或6員飽和雜環或3員至6員之環烷基環； W1及W2各自獨立，分別表示氧原子或硫原子； X表示鹵素原子、氰基、硝基、疊氮基、-SCN、_SF^、 CV6烧基、被R7任意取代之（Cl 6)烷基、c38環烷基、被R7 任意取代之環烧基、C2_6烯基、被R7任意取代之（c2 6)烯基、c3_8環烯基、c3_8鹵代環烯基、c2_6炔基、被R7 任意取代之 c2_6 炔基、-OH、-OR8、-〇s(〇)2R8、-SH、- S(0)rR8、-CHO、-C(0)R9、-C(0)0R9、-C(0)SR9、-C(O) NHR10、-C(O)N(R10)R9、-C(S)OR9、-C(S)SR9、-C(S)NHR10、 -C(S)N(R1Q)R9、-CH=NORn、-C(R9)=NORn、.S(0)2〇R9、 -S(O)2NHR]0、-S(O)2N(R1())R9、-Si(R13)(R14)R12、可被（z1：^ 取代之苯基、L*M，m表示2、3或4時，各個x可彼 此相同或相異’再者’在2個x鄰接之情況’可藉由鄰接 之 2 個 X 形成-CH2CH2CH2-、-CH2CH2〇-、-CH2OCH2-… 9 314918 200407073 och2o-、-ch2ch2s-、-ch2sch2-、-ch2ch2n(r15)-、-ch2n(r15)ch2-、-ch2ch2ch2ch2，、-ch2ch2ch2o-、-ch2ch2och2-、-ch2och2o-、-och2ch2o-、-och2ch2s-、 -CH2CH = CH-、-OCH = CH-、-SCH=CH-、-N(R15)CH=CH-、 -OCH=N-、-SCH=N-、-N(R15)CH=N-、-N(R15)N=CH-、 -CH=CHCH=CH-、-〇CH2CH = CH-、-N = CHCH = CH-、-N=CHCH=N-或-N = CHN = CH-，且與各個所鍵結之碳原子共 同形成5員環或6員環，此時，形成環之各個碳原子所鍵 結之氫原子可被Z1任意取代，再者，在同時被2個以上之 Z1取代之情況，各個Z1可彼此相同或相異； 又，G表示包含至少1個從氧原子、硫原子及氮原子 中選出之原子且環内存在至少1個雙鍵之5員或6員非芳 香族雜環時，X可另表示-N(R17)R16、-N=CHOR12或-N=C (R9)OR12 ; Y表示鹵素原子、氰基、硝基、疊氮基、-SCN、-SF5、 CV6烷基、被R7任意取代之（CV6)烷基、C3_8環烷基、被R7 任意取代之（C3_8)環烷基、-OH、-OR8、-0S(0)2R8、-SH、 -S(0)rR8、-NH2、C】.6 烷胺基、二（CV,烷基）胺基、Si(R13) (R14)R12、可被（Z1：^取代之苯基、L或Μ，n表示2、3或 4時，各個Υ可彼此相同或相異； 再者，在2個Υ鄰接之情況，藉由鄰接之2個Υ形成-CH2 ch2ch2-、-ch2ch2o-、-ch2och2-、'och2o-、-ch2ch2s-、 -CH2SCH2-、-SCH2S-、-CH2CH2CH2CH2-、-CH2CH2CH20-、 -CH2CH20CH2-“CH20CH20-、-0CH2CH20-、-OCH2CH2S-、 10 314918 200407073 -SC^CHJ-、-OCH=N-或-SCH=N…2個γ之各個與其所 鍵結之碳原子可形成5員環或6員環，此時，形成環之各 個碳原子所鍵結之氫原子可被Ζ1任意取代，再者，在同時 被2個以上之Ζι取代之情況，各個ζι可彼此相同或相異； R1，R2及R3各自獨立，分別表示氫原子、氰基、q-I2烷基、被R18任意取代之（C]·!2)烷基、c3 i2環烷基、被 R18任意取代之（C3.,2)環燒基、Cm烯基、被R!8任意取代 之（C3-12)烯基、〔3-12環烯基、C3.12鹵代環烯基、炔基、 被R18任意取代之（C3_12)炔基、-OH、Cu烷氧基、c3_8烯 氧基、Cw鹵代烯氧基、可被（ζι)ρΐ取代之苯氧基、可被 (Z1)P1取代之苯基（C〗.4)烧氧基、Ch6烷硫基、CY6鹵代烷硫 基、可被（Ζ〗）ρ1 取代之苯硫基、-§(0)2119、-81^(；112()；)1119、_ S(0)2N(R，R9、-N(R22)R21、-C(0)R9、-C(〇)〇r9、-c(0)sr9、 -C(0)N(R，R9、-C(S)OR9、-C(S)SR9、_c(s)n(r1〇)r9、可 被（Z1)&quot;取代之苯基、L或M，或者表示藉由R2與R3 一起 形成Gw伸烷基鏈，並與鍵結之氮原子共同形成之3至7 員環，此時該伸烧基鏈可包含1個氧原子、硫原子或氮原 子，且可被鹵素原子、c1-6烷基、Ci 6鹵代烷基、Ci 6烷氧 基、C ! .6烧魏基或C】·6烧氧戴基任意取代； R4表示氫原子、鹵素原子、氰基、Ci6烷基、Cl6鹵 代烷基、被R23任意取代之（CK6)烷基、被R23任意取代之 (Cb6)鹵代烷基、C3_8環烷基、c3-8鹵代環烷基、被R23任 意取代之（C3·8)環烷基、被R23任意取代之（c3 8)鹵代環烷 基、C3.6烯基、C3_6鹵代烯基、c3.6炔基、C3.6鹵代炔基、 π 314918 200407073 -OR8、-S(〇)rR8、-N(R10)R9、_CH0、_c(〇)R9、_c(〇)〇r9、 -C(0)SR9、-C(〇)NHR1G、-C(0)N(r，r9、4(8)〇κ9、_c(s) SR9、-C(S)NHR1G、-C(S)N(R1G)R9、-CH=NOR&quot;、_c(R9)二 NOR&quot;、-Si(R，（RH)Ru、p(〇)(〇R24)2、可被（z2)p】取代之 苯基、1-萘基、2-萘基、L或M ; R5 (a) G表示包含至少1個從氧原子、硫原子及氮原子中選出 之原子且環内存在至少i個雙鍵之5員或6員非芳香族雜 環，或者包含2個從氧原子、硫原子及氮原子中選出之原 子之5員或6員飽和雜環時，R5表示氫原子、鹵素原子、 氰基、c〗·6烧基、Cu鹵代烧基、被r23任意取代之（Cu) 烧基、被R23任意取代之（CY6)鹵代烷基、c3 8環烷基、c3.8 i代環烧基、被R23任意取代之（c3 8)環烷基、被R23任意 取代之（C3-8)鹵代環烧基、c3_6烯基、c3_6鹵代烯基、c3_6 快基、C3_6 iS 代炔基、_〇R8、-S^OLR8、_N(R1G)R9、_CHQ、 -C(0)R9、-C(0)0R9、-C(0)SR9、-C(0)NHR1G、-C(0)N(R10) R9、-C(S)OR9、-C(S)SR9、-C(S)NHR1G、-C(S)N(R1G)R9、 -CH^NOR11、-(^(R^pNOR11、可被（z2)p]取代之苯基、i-萘基、2-萘基、L或Μ ; (b) G表示3員至6員之環烷基環且R4表示氫原子、鹵素 原子、C!.6烧基或Cw鹵代烧基時，R5表示氰基、被R2 3 任意取代之（C!·6)烷基、被R23任意取代之（Ci 6)鹵代烷基、 C3-8環烷基、Cs_8鹵代環烷基、被R23任意取代之（c3 8)環 烷基、被R23任意取代之（(：:3·8)鹵代環烷基、c3.6烯基、C3_6 12 314918 200407073 鹵代烯基、C3.6炔基、C3_6鹵代炔基、-0118、-3(0)氺8、-N(R1G)R9、-CHO、-C(0)R9、-C(0)0R9、-C(0)SR9、-C(O) NHR10、_C(O)N(R10)R9、-C(S)OR9、-C(S)SR9、-C(S)NHR10、 _C(S)N(R10)R9、_CH=N〇RH、_C(R9)=N0Ru、_Si(Ri3)(Ri4) R】2、可被（Z2)pl取代之苯基、i-萘基、2-萘基、L或M ; (c)G表示3員至6員之環烷基環，且R4表示氰基、被r23 任意取代之（C^)烷基、被R23任意取代之6)鹵代烷基、 C3_8環烷基、C3_8鹵代環烷基、被R23任意取代之（c3_8)環 烷基、被R23任意取代之（C3_8)鹵代環烷基、C3.6烯基、C3-6 鹵代烯基、C3_6炔基、C3_6鹵代炔基、-〇以8、_3(〇)氺8、- N(R10)R9、-CHO、-C(0)R9、-C(0)OR9、-C(0)SR9、-C(O) NHR10、-C(O)N(R10)R9、-C(S)OR9、-C(S)SR9、-C(S)NHR10、 -C(S)N(R10)R9 ^ -CH=NORn ^ -C(R9)=NORn &gt; -Si(R13)(R14) R12、-P(0)(0R24)2、可被（Z2)pl取代之苯基、i-萘基、2-萘 基、L或Μ時，R5表示氫原子、鹵素原子、氰基、（Ci6) 烷基、（C^6)鹵代烷基、被R23任意取代之（Ci 6)烷基、被 R任思取代之（C〗_ 6)鹵代烧基、C 3 _ 8環烧基、C 3 _ 8鹵代環：)：完 基、被R23任意取代之（C3_8)環烷基、被R23任意取代之（c3_8) 鹵代環烷基、C3_6烯基、c3_6鹵代烯基、c3_6炔基、c3_6鹵 代炔基、-0118、-8(0)#8、-：^(111())119、-(：110、-(：(0)119、- C(0)0R9、-C(0)SR9、-C(0)NHR1Q、-C(0)N(R1G)R9、-C(S) OR9、_C(S)SR9、-C(S)NHR1G、-C(S)N(R】G)R9、-Ch^NOR11、 -C(R9 卜 NOR&quot;、-Si(R，（RM)Ri2、可被（z2)p]取代之苯基、 l-蔡基、2 -奈基、二或Μ; 】3 314918 200407073 R6表示氫原子、ii素原子、氰基、（Gy)烷基、（Cw) 鹵代烷基、被R23任意取代之（CK6)烷基、被R23任意取代 之（Cu)鹵代烧基、Cs_8壞院基、c3-8鹵代環烧基、被R23 任意取代之（C：3·8)環烷基、被R23任意取代之（C3_8)鹵代環烷 基、C!·6：)：完氧基、CV,鹵代烧氧基、Cl_6烷硫基、Cw鹵代 烷硫基、-S(0)2R9、-C(0)R9、、c(〇)〇R9、-C(0)SR9、-C(S) OR9、-C(S)SR9、-C(0)N(R1G)R9、·ϋ(8)Ν(κ1〇)κ9 _p(〇) (OR24),、-p(s)(〇R，2、可被（Z2)P1取代之苯基、萘基、鲁 2-奈基、L或Μ，1表示2以上之整數，各個R6可彼此相 同或相異； 再者，在R6與R4鄰接之情況，可表示藉由鄰接之…及r6 形成CM伸烷基鏈，並與鍵結之原子共同形成之5至7員 環；此時之伸烷基鏈可包含丨個氧原子或硫原子，且可被 C 1-6烷基任意取代； L表不式L-1至L-58之任一者所表示之芳香族雜環： 14918 14 200407073
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N^/*N L-54 IT% ! f N 〗/71、N一人7叫人，yAJF(z )p：ANi L-55 N 1-56 L-57 N L-58 M表示式M-l至M-28之任一者所表示之飽和雜環 16 314918 200407073 M-l -Ο M-2 ώ° / M-3 ,25 )q2 (〇)r Μ-4 Μ-5 Μ-6 Μ-7
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V
26 (R% ，)rR2Vy Λ-16 R26 ι ,Ν、 Μ-17 Μ·18 (β2% (R25)q3 (R2%4 \25 )q4 Μ-19 Μ20 Μ-21 Μ-22 Μ-23 (R25),3
0 0人V . (R〜V) ^/j M-24 M-25 M-26 s/i (R2%3 由2%3 M-27 M-28 ]7 334918 200407073 Z1表示鹵素原子、氰基、硝基、Ci 6烷基、Cw鹵代 烷基、C3·6環烷基、cs_6鹵代環烷基、6烯基、鹵代 烯基、C2·6炔基、C2_6鹵代炔基、C16烷氧基、鹵代烷 氧基、c】_6烷硫基、Cw ii代烷硫基、Ci 6烷亞磺醯基、Ci-0 鹵代烧亞磺醯基、Cw烷磺醯基、Ci 6鹵代烷磺醯基、Cl_ 6烧胺基、二（Cw烷基）胺基、Ci 6烷氧羰基、ci 6鹵代烷 氧羰基或可被鹵素原子任意取代之苯基，pl，p2，p3或p4 表示2以上之整數時’各個z1可彼此相同或相異； Z2表示鹵素原子、氰基、硝基、胺基、疊氮基、、 _SF5、C1-6烧基、被R7任意取代之Cu烷基、C3-8環烷基、 被R7任意取代之（Cs_8)環烷基、c2_6烯基、被R7任意取代 之（C2_6)稀基、c3-8環稀基、c3-8鹵代環烯基、c2_6炔基、 被 R7 任意取代之（C2_6)炔基、-OH、-OR8、-〇S(〇)2R8、-SH、 -S(0)rR8' -N(R10)R9' - N(R10)CHO&gt; -N(R10)C(O)R9 &gt; -N(R10) C(0)0R9、-N(R10)C(O)SR9、-N(R10)C(S)OR9、- N(R10)C(S) SR9、-N(R10)S(O)2R9、-CHO、_C(0)R9、-C(0)OR9、-C(0) NHR10、-C(O)N(R10)R9、-C(S)NHR10、-C(S)N(R10)R9、-S(〇)2 OR9、-S(0)2NHR10、_S(〇）2N(R10)R9、_Si(R13)(R14)Ri2、可 被取代之苯基、L或M，pl表示2以上之整數時， 各個Z2可彼此相同或相異； 再者，在2個Z2鄰接之情況，可藉由鄰接之2個Z2形成 •ch2ch2ch2-、-CH2CH20-、-CH2OCH2-、-0CH20-、、CH2 ch2s- ^ -CH2SCH2- ' -ch2ch2ch2ch2- &gt; -ch2ch2ch2〇.. -ch2ch2och2-、-ch2och2o-、-OCH2CH2〇-或-och2 3]4918 18 200407073 CHj 並/、2個Z之各個鍵結之碳原子共同形成5員環 或6員壞，此時，形成環之各個碳原子所鍵結之氫原子可 被鹵素原子或Cl-6烷基任意取代； R7表示i素原子、氰基、c3-8環烷基、c38鹵代環烷 基、-OH、-OR8、-SH、-S(〇) r8、_n(r1())r9、n(r1G)ch〇、 -N(R1Q)C(0)R9、- n(riq)c(〇)〇R9、n(r】〇)c(〇)sr9、-N(r10) C(S)OR9、-N(R10)c(S)SR9、-N(R1g)S(O)2R9、-C(O)OR9、- C(C〇N(n1())R9、_Si(Ri3)(Rl4)Rl2、可被（z】)pi 取代之苯基、 L或Μ ; R8表不C1-6烷基、被R27任意取代之烷基、c3 8 環烧基、被R27任意取代之（C3 8)環烷基、C2 6烯基、被r” 任意取代之（C2_6)烯基、C3-8環烯基、c3_8鹵代環烯基、c3.6 快基被R任意取代之（c3_6)炔基、可被（z】）pl取代之苯 基、L或Μ ; r9表示c&quot;烷基、c】_6鹵代烷基、c3_6環烷基（(：】_4)烷 基、c】·6烧氧基（Ci4)烧基、Ci6烧硫基（Ci4)烧基、氰基（Ci6) 烧基、可被（Z%]取代之苯基（Cl_4)烷基、l-(CV4)烷基、Μ-(Cw)烷基、c3_8環烷基、c3-8鹵代環烷基、c3_6烯基、c3_ 6鹵代烯基、c3.6炔基或可被（z1)^取代之苯基；
RlG表示氫原子或（：〗·6烷基，或者表示藉由R9與RK 一起形成C2_6伸烷基鏈，並與鍵結之原子共同形成之3至 7員環，此時之伸烷基鏈可含有1個氧原子、硫原子或氮 原子’且可被鹵素原子、C】.6烷基、（^_6烷氧基、曱醯基、 C】_ 6少元基基或c ] _ 6烧氧基幾基任意取代； 19 314918 200407073 R11表示氫原子、C】_6烷基、Ci6 _代烷基、可被（π)〆 取代之苯基（C〗·4)烷基、Cw烯基、c3 6鹵代烯基、c3 6炔 基或Cs_6鹵代炔基，或者表示藉由R9與Rll 一起形成 伸院基鏈，並與鍵結之原子共同形成之5至7員環，此時 之伸烷基鏈可含有1個氧原子、硫原子或氮原子，且可被 鹵素原子或烷基任意取代； R12表示Cw烷基、Cl_6鹵代烷基、c3 6烯基或可被（zl)w 取代之苯基； R13及R14各自獨立，表示Ci6院基或Ci_6 _代烷基； R15表示氫原子、Cw烷基、Ci 6 _代烷基、Ci 6烷氧 基羰基（c^)烷基、Cl·6鹵代烷氧基羰基（Ci 4)烷基、可被 (z )pl取代之笨基（Ch)烷基、cs_6烯基、c3-6鹵代烯基、 c^6炔基或cs_6鹵代炔基、Ci_6烷氧基、6烷氧基羰基、 c^鹵代烷氧基羰基或可被（ζι)ρ】取代之苯基； R表示氫原子、Cw烷基、c〗_6鹵代烷基、c:3 6環烷 基（Cw)烷基、c^4烷氧基（Ci4)烷基、Gy烷硫基（Ci4)烷 基可被（Z )pi取代之苯硫基（Cw)烷基、氰基（Ci6)烷基、 烷氧基羰基（c】·4)烷基、（：]_6烷胺羰基（Ci 4)烷基、二 (^!·6烷基）胺基羰基（Cw)烷基、可被（zl)pi取代之苯基（Cw) 浼基、L-(CY4)烷基、M_(Ci 4)烷基、6環烷基、C3_6烯基、 c3.6鹵代烯基、c3_6炔基、c3-6鹵代炔基、_〇H、C16烷羰 氧基、C】·6烷硫基、c]·6鹵代烷硫基、可被取代之苯 ’丨L基C】-6燒石男®强基、C]·6鹵代烧石黃酸基、可被（ζι)ρ】取代 之笨磺醯基、-SN(R2G)R】9、C10烷胺磺醯基、二（c&quot;烷基） 314918 20 200407073 胺磺醯基、-CHO、-C(0)R9、-C(0)0R9、-C(0)SR9、-C(0) nhri、c(0)n(ri〇)r、c(s)〇r9、_c(s)sr9、_c(s)nhr】0、 -C(S)N(R1〇)R^ -C(0)C(〇)R9^ -c(〇)C(〇)〇r9&gt; -p(〇)(〇r24)2 或-P(S)(〇R2”2 ; R17表示氫原子、c〗_6烷基、Cw鹵代烷基、c3 8環烷 基（Cl-6)烧基、C3_8環：)：完基、c3-6烯基、c3_6鹵代烯基、c3_ 6快基、c3_6鹵代炔基、-CH0、Ci-6烷羰基、ci6鹵代烷羰 基或Cl-6烧氧羰基；或者表示藉由R16與7 一起形成 伸烧基鏈，並與鍵結之原子共同形成之3至7員環，此時 之伸烷基鏈可含有丨個氧原子、硫原子或氮原子，且可被 鹵素原子、Cw烷基或C!·6鹵代烷基任意取代；再者可表 示藉由R&quot;與R2 —起形成Ci_2伸烷基鏈，並與鍵結之原子 共同形成之與苯環稠合之6或7員雜環，此時之伸烧基鏈 可被氧原子或C!_6烷基任意取代； R18表示鹵素原子、氰基、硝基、c：3 8環烷基、鹵 代環烷基、-OR28、-N(R29)R28 …SH、_s(〇) r3g、、 -c(o)R3i、c(0)OH、_c(〇)〇r31、c(〇)sr31、c⑼随r32、 -c(o)n(r3”R3〗…c(0)c(〇)〇r31、-c(r34)，〇h、c(r34)= N〇R33、Si(Ri3)(RH)Rl2、p(〇)(〇R24)2、p(s)(〇R24)2、邛（苯
基）2、-P(0)(苯基）2、可被（Zl)pl取代之笨基、L或M 垸氧基（c^ 2)燒基、可 鹵代烯基、 烧氣纟炭基或
Rl9表示〇ν12烷基、C].12鹵代烷基、Ci 1 - ]2)燒基、氰基烷基、（^12烷氧羰基（C] 被（Z1：^取代之苯基（c]4)烷基、C312烯基、c， J -
块基、C3_12鹵代炔基、c】_12烷羰基、G J # 314918 21 200407073 可被（z1)&quot;取代之苯基； R20表不CVi2烷基、C]12 _代烷基、烷氧基（q 〗2)烷基、氰基（C卜】2)烷基、Ci·】2烷氧羰基（C1_】2)烷基、可 被（z1：^取代之苯基（C〗·4)烷基、C3_u烯基、c3」2鹵代烯基、 C：3·】2炔基、Cm _代炔基、或可被（zl)y取代之苯基，或 者表示藉由R與R2G —起形成C4 7伸烧基鏈，並與鍵結 之II原子共同形成之5至8員環，此時之伸烧基鍵可含有 1個氧原子或硫原子，且可被Ci_4烷基或Ci 4烷氧基任意 取代； R21表不氫原子、Cb6烷基、（：卜6鹵代烷基、可被（z〇pi 取代之苯基（q·4)烧基、c：3_6烯基、c3 6鹵代烯基、c3 6炔 基、-cho、cv6烷羰基、Ci 6鹵代烷羰基、Ci 6烷氧羰基、 Cu鹵代烧氧魏基、可被（ζι)ρΐ取代之苯基（Ci 4)烷氧羰基、 可被（ZOpi取代之苯氧羰基、可被（ζι)ρΐ取代之苯羰基或可 被（Z1)^取代之苯基； R22表示氫原子、Cu烷基、-CHO、CV6烷羰基、Cu 鹵代烷羰基或（^_6烷氧羰基； R23表示氰基、C3_8環烷基、c3_8鹵代環烷基、-OH、 -OR8、-SH、-S(0)rR8、-N(R10)R9、-N(R10)CHO、_N(R10)C (O)R9、-N(R10)C(O)OR9、-n(R10)C(O)SR9、-N(R10)C(S) OR9、-N(R10)C(S)SR9、·ν(Κ】0)8(Ο)2Ι19、-C(0)0R9、-C(0)N (R1G)R9、-Si(R13)(R14)Ri2、可被（zl)M 取代之苯基、L 或 M; R24表示C]_6烷基或Cw鹵代烷基； R25表示鹵素原子、氰基、（:]6烷基、CV6鹵代烷基、 22. 314918 200407073 經基u烧基、c]_4燒氧基（Ci4)烧基 4)烧基、C&quot;烧氧基、C “说氧板基（C]- I·6烷虱铍基或可被（ζΟρ]取代之苯 基，…、q2、q3 $ q4表示2以上之整數時各個ρ可彼 此相同或可彼此相異； —表尸、氫原子烧基、C〗_6鹵代烧基、-CH〇、 吖6烷羰基、。“由代烷羰基、可被(zl)p丨取代之苯基％ 4)烷羰基、Cl·6烷氧羰基、Ci·6齒代烷氧羰基、可被（zi)m 取代之苯基（Cw)烷氧羰基、Ci_6烷胺羰基、二（Cw烷基） 胺羰基、C!-6烷胺硫羰基、二（Cw烷基）胺硫羰基、可被（zl)pi 取代之苯羰基' C!·6烷磺醯基、ci 6鹵代烷磺醯基、可被 (Z1)^ 取代之苯磺醯基、-p(〇)(〇R24)2 或 _p(s)(〇R24)2 ; R27表示鹵素原子、氰基、C3 8環烷基、C3 8鹵代環烷 基、Cu烧氧基、Cw鹵代烷氧基、c1-6烷硫基、cv6鹵代 烧硫基、CV6烧續酸基、cv6鹵代烧磺it基、cU6烧胺基、 二（c】_6烧基）胺基、-CHO、C1-6烧羰基、C1-6鹵代烧羰基、 C】-6烷氧羰基、CV6鹵代烷氧羰基、-CH^NOR11、-C(R9) = NOR11、可被（Z1)^取代之苯基、L或Μ ; R28表示氫原子、Cw烷基、可被R35任意取代之（CV8) 烷基、C3_8環烷基、可被R35任意取代之（C3_8)環烷基、C3.8 烯基、可被R35任意取代之（C3.8)烯基、C3_8炔基、可被R35 任意取代之（C3_8)炔基、-CHO、-C(0)R31、-C(0)0R31、-C(O) SR31、-C(0)NHR32、-C(0)N(R32)R31、-C(0)C(0)R3】、_C(0)C (0)〇R31、-C(S)R3】、-C(S)OR31、-C(S)SR31、-C(S)NHR32、 -C(S)N(R32)R3】…S(0)2R31、_S(0)2N(R32)R3]、-Si(R13)(R】4) 23 3J4918 200407073 R12、-P(〇K〇R24)2、-P(s)(〇r24)2、可被（zl)M 取代之苯基、 L或Μ ; R表示氫原子、CK0烧基、（^·6鹵代烷基、c3 6環烷 基或c^6烷氧基，或者表示藉由尺以與R29 一起形成 伸烷基鏈，並與鍵結之氮原子共同形成之3至6員環，此 時之伸烷基鏈可含有丨個氧原子或硫原子，且可被鹵素原 子、烷基、Cw烷氧基或可被（zi)w取代之笨基取代； 表不C&quot;烷基、可被R35任意取代之（u烷基、 C3.8環烷基、可被R35任意取代之（(：3 8)環烷基、烯基、 可被R35任意取代之⑷3·8)烯基、Cw炔基、可被R35任意 取代之（cs_8)炔基、_SH、Ci 6烷硫基、6鹵代烷硫基、可 被（z )P1 取代之苯硫基、-(^110、-(^(0)尺31、-(^(0)0以31、_ C(0)SR31、-C(〇)NHR32、-C(0)N(R32)R31、-C(0)C(0)R31、 -C(0)C(0)0R:1、_C(S)R31、-c⑻〇r3〗、_c(s)sr3i、_c(s) NHR32、-C⑻N(R32)R31、-P(0)(0R24)2、-p(s)(or24)2、可 被（Z1)^ 取代之苯基、、L-21、L-25、L-30 至 L-35、 L-45 、 L-48 、 L-49 或 M ; 表示c1-6烷基、cv6鹵代烷基、c3.8環烷基（u 少兀基C1-6烧氧基（C^4)烧基、C〗-6鹵代烧氧基（ci-4)烧基、 Cu燒硫基（C14)烷基、cl 6鹵代烷硫基（Ci 4)烷基、Ci 6烷 石只酉皿基（C】·4)烷基、C16鹵代烷磺醯基（c】_4)烷基、氰基（c】_6) 少兀基、c】_6烧羰基（Ci 4)烷基、C16鹵代烷羰基（Ci 4)烷基、 Cl·6烷氧羰基（c】.4)烷基、二（C^6烷基）胺羰基（U烷基、 二（C】·4烷基）矽烷基烷基、可被（Z】)pl取代之苯基（Ci 4) 314918 24 200407073 烧基、l-((v4)垸基、M-(c】_4)烷基、c3_yf、烷基、c3 8鹵代 環烷基、c2_6烯基（C3_8)環烷基、C2 6 _代烯基（C3 8)環烷 基、c2_6烯基、c2_6鹵代烯基、c2_6炔基、c2-6鹵代炔基、 可被（Z1)^取代之笨基、L或Μ ; R表示氫原子、Ci_6烧基、C】_6鹵代烧基或可被（zi)y 取代之苯基，或者表示藉由R3】與R32 一起形成C25伸烷 基鏈’並與鍵結之氮原子共同形成之3至6員環，此時之 伸烧基鏈可含有1個氧原子、硫原子或氮原子，且可被鹵 素原子、ον,烷基、Cl_6烷氧基、甲醯基、Cl 6烷羰基、Ci 6 烧氧羰基或可被（冗^…取代之苯基任意取代； R33表示氫原子、C!.8烷基、被R35任意取代之（Ci8) 烷基、cs_8環烷基、C3·8烯基、被r35任意取代之烯 基、Cs_8炔基或被R35任意取代之（c3 8)快基； R34表示氳原子、Cw烷基、C16鹵代烷基、c3-8環烷 基（c!_4)烧基、c^6：)：完氧基（u烧基、c!_6鹵代烧氧基d. 4)燒基、C!·6烧硫基（CY4)烧基、Cb6 _代烧硫基（Cw)烷基、 C!·6烷磺醯基（C^4)烷基、Cu鹵代烷磺醯基（cl-4)烷基、可 被（Z])p】取代之苯基（Ch4)烷基或可被（ζι)ρΐ取代之苯基； R35表示鹵素原子、氰基、硝基、C3_8環烷基、c3_8鹵 代環烧基、-OH、-OR36、-SH、-S(〇)rR36、-NHR37、-N(R37) R。6、- CHO、- C(0)R31、C(0)0R31、c(0)SR31、- C(0)NHR32、 ‘C(〇)N(R32)R31、-C(0)C(0)0R3】、-CH=N〇R&quot;、-C(R9) = nor】1、-Si(Rh)(R14)R12、-P(〇)(〇r24)2、p(s)(〇R24)2、p(笨 基）2、-P(0)(苯基）2、可被（z】)pl取代之苯基、L或M ; 25 314918 200407073 R36表示C1-6烷基、C]_6鹵代烷基、C】_6烷氧基（C1-4) 烷基、CV6烷硫基（Cm)烷基、可被（Z〗）pl取代之苯基（U 烷基、（C3_8)環烷基、（C3_8)鹵代環烷基、C3_6烯基、C3-6鹵 代烯基、C3_8環烯基、C3_8鹵代環烯基、C3_6炔基、c3_6鹵 代炔基、-CHO、cv6烷羰基、C〗_6鹵代烷羰基、C&quot;烷氧 爹炭基、Cu鹵代烧氧獄基、C1-6烧胺^基、一（CK6烧基）胺 罗炭基、可被（冗^…取代之苯幾基、烧胺硫幾基、二（C] 6烷基）胺硫羰基、可被（z])pl取代之苯基、L或M; R37表示氫原子、Cw烧基、C】_6鹵代烧基、c3_8環烧 基、c3_6烯基、c3_6炔基、c!_6烧幾基、c〗_6鹵代烧幾基、 C!-6烷氧羰基、Cl_6鹵代烷氧羰基、可被（z1)^取代之苯氧 罗炭基、可被（zi)pl取代之苯羰基、Cw烷磺醯基、Ci 6鹵代 烧磺醯基、可被（z1：^取代之苯基、L或M，或者表示藉由 R36與R37 —起形成C2·5伸烧基鏈，並與鍵結之氮原子共同 形成之3至6員環，此時之伸烷基鏈可含有1個氧原子或 硫原子，且可被鹵素原子或曱基取代； 1表示0至9之整數； m表示〇至4之整數； n表示0至4之整數；
Pi表示1至5之整數； P2表示〇至4之整數； P3表示〇至3之整數； P4表示〇至2之整數； P5表示〇或1之整數， 314918 26 200407073 ql表示0至3之整數； q2表示0至5之整數； q3表示0至7之整數； q4表示〇至9之整數； r表示0至2之整數；以及 t表示0或1之整數]。 [2]如上述[1]之取代1苯（甲）醯苯胺化合物或其鹽 其中： 八里 X表示幽素原子、氰基、硝基、_SF5、Ci6烷基、 鹵代烷基、C：2·6炔基、Ci_6烷氧基、Ci_6鹵代烷氧基、 烷硫基、C!·6鹵代烷硫基、Ci·6烷亞磺醯基、_代烷亞 磺醯基'Cw烷磺醯基、Ci_6鹵代烷磺醯基、c“烷氧羰基、 烷胺羰基、二（Ci_6烷基）胺羰基或可被取代之苯 基，m表示2、3或4時，各個X可彼此相同或相異， 再者，在2個X鄰接之情況，可藉由鄰接之2個χ形成_ ch2ch2ch2-&gt; -ch2ch2〇^ -ch2och2-&gt; -och2o— -ch2ch2 S-、-ch2sch2·、_ch2ch2ch2ch2·、_ch2ch2ch2o…ch2 CH2〇CH2-、-CH2〇CH2〇-、_〇ch2CH20-、-och2ch2s-或- CH-CHCI^CH- ’且與各個所鍵結之碳原子共同形成5員 %或6員ί哀’此時，形成環之各個碳原子所鍵結之氫原子 可被函素原子、C】·4少完基或C!-4鹵代烧基任意取代； 又 G表示包含至少1個從氧原子、硫原子及氮原子 中廷出之原子且環内存在至少1個雙鍵之5員或6員非芳 曰私7Γ隹環妗，X可另表示-N(R】7)R】6、-N=CH〇Ri2或 27 314918 200407073 (R9)OR12 ; Y表示鹵素原子、氰基、Ci6烷基、C16鹵代烷基、羥 基（CI-6)烷基、CN3烷氧基（Ci3)烷基、烷氧基、鹵 代烷氧基、Cw烷硫基、ci 6鹵代烷硫基、烷胺基、二 (Cw烷基）胺基、可被（ζι)ρΐ取代之苯基或可被（zl)w取代 之苯氧基，η表示2、3或4時，各個γ可彼此相同或相異， 再者，在2個Υ鄰接之情況，可藉由鄰接之2個γ形成^ ch2ch2ch2_、-ch2ch20-、-ch2och2-、-och2o-、-CH2CH2 ch2ch2-、-ch2ch2ch2〇-、-ch2ch2och2-、-ch2och2o、 -OCH2CH20_、·〇〇：Η=Ν·或_S_CH=N_，且與各個所鍵結之碳 原子共同形成5員環或6員環，此時，形成環之各個碳原 子所鍵結之氫原子可被_素原子、C14烷基或c14鹵代烷 基任意取代； R1及R2各自獨立，分別表示氫原子、c】_6烷基、C&quot; 鹵代烷基、Cw烷氧基（Ci_4)烷基、Ci_4鹵代烷氧基（U 烷基、c^4烷硫基（c】_4)烷基、Ci 4鹵代烷硫基（Ci 4)烷基、 C!-4烷磺醯基烷基、Ci_4鹵代烷磺醯基（Ci4)烷基、可 被取代之苯硫基（Ci_4)烷基、Cs·6烯基、c3 6 ώ代烯 基、C3_6炔基、c3_6鹵代炔基、Ci 6烷硫基、6 _代烷硫 基、可被（冗^…取代之苯硫基或-SN(R2〇)Rl9 ; R'表示C】_8烷基、被RI8任意取代之（Ci j烷基、 3-8 環:^基、C]-4烧硫基（c3.6)環燒基、Cu :)：完亞續酿基（匕J 壞烷基、C】·4烷磺醯基（C：3·6)環烷基、羥曱基（(：3_6)環烷基、 C]-4烷氧甲基（c3_6)環烷基、1_4烷硫甲基（c3_6)環烷基、c _ 314918 28 200407073 烷亞磺醯甲基（cw)環烷基、c】_4烷磺醯甲基（c3_6)環烷基、 C3-8烯基、q·6烷胺羰基（c36)烯基、可被（zi)w取代之苯 基（C3_6)烯基、c38炔基、可被（zl)pi取代之苯基（Cm)炔基、 奈基（C3·6)炔基、l-(c3_6)炔基、Ci-8烷氧基、c3 8鹵代烯氧 基、M-4、M-5、M-8、M-9、M-13 至 M-19、M-21、M-22、 M-2 5或M-28,或者藉由R2與R3 一起形成c2 6伸烷基鏈， 亚與鍵結之氮原子共同形成之3至7員環，此時之伸烷基 鏈可含有1個氧原子或硫原子，且可被Ci 6烷基任意取 代； R4表示氫原子、鹵素原子、Cl_6烷基、鹵代烷基、 被R23任意取代之（C!·6)烷基、被R23任意取代之（(^_6)鹵代 烧基、Cw環烧基、C3 8鹵代環烷基、被r23任意取代之（c J衣烧基、被R23任意取代之（C3_8)鹵代環烷基、C3_6烯基、 C3-6 i 代烯基、C3_6 炔基、c3-6 鹵代炔基、-OR8、-S(0)rR8、 -N(R]〇)R9、ci-6 院氧羰基、_CH=N〇Rn、_C(R9)=NOR&quot;、 •Si(R13)(r&quot;)r12、_p(〇)(〇R24)2、可被取代之苯基、 案基、2-萘基、L或μ ; R5 U)G表示含有至少1個從氧原子、硫原子及氮原子中選出 之原子且環内存在至少1個雙鍵之5員或6員非芳香族雜 5展或者含有2個從氧原子、硫原子及氮原子中選出之原子 之5員或6員飽和雜環時，R5表示氫原子、鹵素原子、氰 基、C】·6烧基、Ci 6鹵代烷基、被r23任意取代之（Ci 6)烷 基、被R23任意取代之（c]6)鹵代烷基、C3.8環烷基、c3_8 29 314918 200407073 鹵代環烷基、被R23任意取代之（C3_8)環烷基、被R23任意 取代之（C3.8)鹵代環烷基、C3_6烯基、C3-6鹵代烯基、C3_6 炔基、C3_6 鹵代炔基、-OR8、-S(0)rR8、-N(R10)R9、-CHO、 -C(0)R9、-C(0)0R9、-C(0)SR9、-C(〇)N(R1())R9、-C(S)N (R1G)R9、-CH=NORn、-C(R9)=NOR&quot;、可被（Z2)pl 取代之苯 基、1-蔡基、2-蔡基、L或]VI; (b) G表示3員至6員之環烷基環且R4表示氫原子、鹵素 原子、C1-6烧基或Cb6鹵代烧基時’ R5表示氰基、被R2*3 任意取代之（c^)烷基、被R23任意取代之（Chd鹵代烷基、 C3_8環烷基、C3_8鹵代環烷基、被R23任意取代之（C3_8)環 烷基、被R23任意取代之（C3_8)鹵代環烷基、C3_6烯基、C3-6 鹵代烯基、C3_6炔基、C3_6鹵代炔基、-OR8、-S(0)rR8、-N (R10)R9、-CHO、-C(0)R9、_C(0)0R9、-C(0)NHR1G、-C(0)N (R10)R9、-C(S)NHR1Q、-C(S)N(R1Q)R9、-CH=NORn、-C(R9) = NOR11、-Si(R13)(R14)R12、可被（Z2)pl 取代之苯基、1-萘基、 2-萘基、L或Μ ; (c) G表示3員至6員之環烷基環，且R4表示氰基、被R23 任意取代之（Cb6)烷基、被R23任意取代之（Cu)鹵代烷基、 C3_8環烧基、C3-8鹵代環燒基、被R2。任意取代之（匸3-8)壞 烧基、被R2&quot;3任意取代之（C3-8)鹵代壞烧基、C3-6炸基、Cg-6 鹵代烯基、c3.6炔基、c3.6 i|代炔基、-OR8…S(0)rR8、-N(R1G)R9、c】_6 烷氧羰基、-Si(R13)(R14)R】2、-P(0)(0R24)2、 可被（Z2)pI取代之本基、1-蔡基、蔡基、L或Μ時’ R-表示氫原子、鹵素原子、氰基、Cl-6烷基、C】_6鹵代烷基、 30 314918 200407073 被R23任意取代之（Cb6)烷基、被R23任意取代之（c]-6)_代 烷基、c3_8環烷基、c3_8鹵代環烷基、被R23任意取代之（C3·8) 環烷基、被R”任意取代之（C3_8)鹵代環烷基、C3·6烯基、 C3_6 鹵代稀基、C3_6 快基、C3_6 ii 代炔基、-OR8、-S(0)rR8、 -n(r1g)r9、-cho、-c(o)r9、-c(o)or9、-c(o)nhr1()、- C(0)N(R1g)R9、-C(S)NHR1g、-C(S)N(R1g)R9、-CH=NORn、 -C(R9)=NOR&quot;、-Si(R13)(R14)R12、可被（Z2)pl 取代之苯基、 1-萘基、2-萘基、L或Μ ; R6表示氫原子、鹵素原子、氰基、CV6烷基、Cw鹵 代烷基、被R23任意取代之（Cb6)烷基、被R23任意取代之 (CVJ鹵代烷基、（：3_8環烷基、C3.8鹵代環烷基、被R23任 意取代之（C3_8)環烷基、被R23任意取代之（C3_8)鹵代環烷 基、-S(0)2R9、Cw烷羰基、CV6鹵代烷羰基、可被（Ζ])ρ1 取代之苯羰基、-C(〇)〇R9、-C(0)SR9、-C(0)N(R1G)R9、二 (Cw烷基）磷醯基、二（Cw烷基）硫代磷醯基、可被（z2)pl 取代之苯基、L或μ ;或者在R6與R4鄰接之情況，可表 示藉由鄰接之R4及R6 —起形成C3_5伸烷基鏈，並與鍵結 之原子共同形成之5至7員環；此時之伸烷基鏈可包含1 個氧原子或硫原子，且可被Cl_6烷基任意取代； Z2表示鹵素原子、氰基、硝基、胺基、cK6烷基、〇ν6 i代烧基、烷氧基（Ci 3)烷基、Cl_3鹵代烷氧基（Cl 3) 烧基、Cw烧硫基（C]3)烧基、Cl3 _代烧硫基烷基、 c】·3烧亞續si基（c】3)烷基、c]3鹵代烷亞磺醯基（Ci3)烷 基、C】-3烧石黃酿基（c】_3)烷基、c】_3鹵代烷磺醯基 31 314918 200407073 基、氰基（Cw)烧基、無基（c]_3)鹵代烧基、c^3燒氧基（q 3) 鹵代烷基、Cw鹵代烷氧基（C!.3)鹵代烷基、〇38環烧基、
Cs·8鹵代環烧基、c〗_6烧氧基、Cw鹵代烧氧基、鹵代 少元氧基d.3)鹵代烧氧基、C^6烧續酿氧基、C ! 6 _代烧石黃 醯氧基、可被（Z”pl取代之苯氧基、-〇(L-45)、Ch6烧硫基、 C^6鹵代烧硫基、C^8環烧硫基、可被（z1)^取代之苯硫美、 -S(L-45)、C〗_6烧亞石黃酸基、C1-6鹵代烧亞石黃酿基、c，環 烧亞磺酸基、可被（Z1)^取代之苯亞續驢基、_§(〇)仏_4〇、 C i _6烧磺醯基、C i _6鹵代烧續醯基、C3 _8環烧續酿基、可被 (Z1：^取代之苯磺醯基、-S02(L-45)、Cb6烷胺基、二（c 烧基）胺基、Cw烧胺％ 基、二（C!·6烧基）胺續酿基、〔 6烷磺醯胺基、CV6鹵代烷磺醯胺基、-C(0)NH、「 ^ ’ 2 烷胺 羰基、二（CV6 烷基）胺羰基、-C(S)NH2、-Si(Ri5)(Rl6)Rl4、 可被（Z】）pl 取代之苯基、L-5、L-14、L-24、L-36、 L-41、L-42、L-43、L-44或M，pi表示2以上之整數护 各個Z2可彼此相同或相異； 形成 再者，在2個Z2鄰接之情況，可藉由鄰接之2個z: -CF2CF20-、_CF2OCF2 -或- 0CF20-並與各個所鍵么士 山 &lt;兔原 子共同形成5員環； 環燒基(C， ^鹵代烯 R8表示CV6烧基、CV6鹵代烷基、c 基、c3.8環烷基、c3-8鹵代環烷基、c2_6烯基、c 基、C3.8環烯基、C3-8鹵代環烯基、C3-6炔基、C 基、可被（Z%]取代之苯基、L或Μ ; 環烷基(CK4)烷
R9表示C】_6烧基、CV6鹵代烧基、C 3149] 8 32 200407073 基、可被（Ζ%ι取代之苯基（Ci·4)烷基、l_(Ci_4)烷基、M兴Ci j
烧基 ^3·8環烧基、C3.8鹵代環烧基或可被（zi)pi取代之苯 基； 。I R表示氫原子或c〗·6烧基，或者表示藉由尺9與尺1〇 起形成6伸烧基鏈，並與鍵結之氮原子共同形成之3 至7員環，此時之伸烷基鏈可含有丨個氧原子或硫原子； R表示氫原子、cK0烷基、c1-6鹵代烷基或可被（ζι)ρΐ 取代之苯基（C1·4)烷基，或者藉由R9與R11 —起形成c2_3 伸烷基鏈，並與鍵結之原子共同形成5或6員環，此時之 伸烷基鏈可含有i個氧原子、硫原子或氮原子，且可被 烷基任意取代； R表不C】·6烷基或可被（ζι)ρΐ取代之苯基； R及R14各自獨立，表示C16烷基； R表示C1-0烧基、Cu鹵代烧基、可被（ζι)ρΐ取代之 苯基（C〗_4)烷基或可被（ζι)ρΐ取代之苯基； R表不氫原子、c〗·6烷基、c36環烷基（Ci4)烷基、 c】_4烷氧基（C&quot;)烷基、Ci_4烷硫基（Ci 4)烷基、環烷基、 c3二1基、c3_6i代烯基、Cs_6炔基、C3 6函代炔基、 烧”1基（3】.6_代烧績酸基、4只0、-(](0)以9、-(1；(0)0119、 C(0)SR、-C(〇)N(R10)R9、-C(s)〇r9、c(s)sr9 或 _c(s)N (R10)R9 ; R”表不氫原子或烷基，或者藉由R17與R2 —起 形成Cu伸烷基鏈，並與鍵結之原子共同形成與苯環稠合 之6貝或7貝雜環，此時之伸烧基鏈可被烧基任意取 314918 200407073 代； R18表示鹵素原子、氰基、C3_6環烷基、_〇R28、_n&lt;r2~ R28、-SH、-S(0)rR3G、-CHO、CV6 烷羰基、c] 6 烷氧魏基、 _C(0)N(R32)R3】、-C(R34)二NOH、C(R34)=N〇R33、_si(Ri3) (R14)R12、可被（Zi)pl 取代之苯基、L-l、L-2、、 L-45 、 L-46 、 L-47 或 M ; R19表示cv6烷基、cv6烷氧羰基烷基或Cl 6烷 氧羰基； R2G表示CV6烷基，或者藉由rb與r2〇 一起形成c 伸烷基鏈，並與鍵結之氮原子共同形成之5員環或6員環， 此時之伸烷基鏈可含有1個氧原子或硫原子，且可被甲基 或曱氧基任意取代； 表示氰基、C3·8環烷基、C：3 8鹵代環烷基、烷 氧基、C】·6鹵代烷氧基、可被（ζι)ρΐ取代之苯氧基、烷 硫基、可被（z】）pl取代之苯硫基、Ci_6烷磺醯基、_代 烧〜基、可被（z )pl取代之苯確酿基、ci 6烧孰幾基、c 土 1-6 鹵代燒氧羰基、二（CV6统基）胺羰基、-Si(R13)(R14)Rl2、可 被取代之苯基、L或Μ ; R25表示Cu烷基、c1-6鹵代烷基或c1-6烷氧基，ql、 q2、q3或q4表示2以上之整數時，各個R25可彼此相同， 亦可彼此相異； R26表不-CHO、Cw烷羰基、烷氧羰基、Gy烷胺 叛基、二（C〗.6烷基）胺羰基、可被^。…取代之苯羰基、 烧石頁釀基或c ]· 6鹵代燒石黃酿基； 314918 34 200407073 R28表示氫原子、Ci_6烧基、c].6鹵代烧基、C]_4少兀氧 基（Cw)：)：完基、（^_4烧硫基（Ci_4)烧基、可被（ζ1)^^*代之本 基（Cw)烷基、c3.8環烷基、C3_8烯基、c3_8炔基、-CHO、 CV6烷羰基、〇^_6鹵代烷羰基、c3_6環烷羰基、可被（Ζ1)^ 取代之苯羰基、C16烷氧羰基、-C(0)N(R32)R31、-C(S)N (R32)R31、Cw烷磺醯基、c^.6鹵代烷磺醯基、可被（Z])pl 取代之苯磺醯基、二（Ci_6烷基）胺磺醯基、二（CN6烷基）磷 醯基、二（C1-6烷基）硫代磷醯基、-Si(R13)(R14)R12或可被 (ZDpl取代之苯基； R29表示氫原子、Cb6烷基或Cw烷氧基； R3G表示CV6烷基、被R35任意取代之（Ch)烷基、c3_ 6環烧基、C3_6烯基、c3_6炔基、cIe6烷硫基、可被（ζι)ρ1 取代之苯硫基、C16烷羰基、Ci6烷胺羰基、二（Ci4烷基） 胺獄基、（^_6烷胺硫羰基、二（C14烷基）胺硫羰基、可被（zl)pl 取代之苯基、L-21、L-35、L-45 或 L-48 ; R表示cv6烧基、CV6鹵代烷基、C3_8環烷基（c1-4) 烧基、Gw烷氧基（Ci_4)烷基、Ci·4烷硫基（Ci4)烷基、可被 (Ζ])ρ1取代之笨基（c〗4)烷基、（]_45)- (c】4)烷基、（L_46)_ (Cw)烷基、（L-47HCi_4)烷基、C3 6環烷基、C3 6烯基、 快基、或可被（zl)pi取代之苯基； R32表示氫原子或Cl_6烷基，或者表示藉由RS1與R32 起形成C2·5伸烷基並與鍵結之氮原子共同形成之3至6 貝％，此時之伸烷基鏈可含有1個氧原子、硫原子或氮原 子，且可被c〗.6烷基、c]·6烷氧基、曱醯基、6烷羰基 314918 35 200407073 或C!.6燒氧幾基任意取代； 烧基、c3.6環烧基(Ci4)垸基、c“烧氧基 〜冰基、Cl-4烧硫基(Ci-4)烧基、Ci4燒氧幾基(c&quot;)烧 基、-（C“4烧基）胺幾基（Ci4)烧基、c36稀基或 取代之苯基（C1.4)烷基； )pl 〔表示氫原子、u基或可被（Z%取代之苯基； 、表不_素原子、QH、c&quot;燒氧基、烧幾氧基、
Cl·4鹵代烷叛氧基、Cl·4烷硫基、Ci-4烷羰基、C】_4烷氧羰 基、一（Cw 烷基）胺羰基、_si(Rl3)(Rl4)Ri2 被 代之苯基。 化取 [3]上迷[2]之取代笨（甲）醯苯胺化合物或其鹽，苴 中： ^ G表示式G-ι、彳r 卜 、 式 G_4、式 G-5、式 G-6、式 G-7、式 G-8、式 G_u、式 Λ 广 π 、h12、式 G-13、式 G-14、式 G-15、式 G-17、式 G-18、式 式 4 、b·21、式 G-22、式 G-23、式 G-32、 式 G~33、式 G-40、々 〇 之任一 式G、41、式G-42、式G-53或式G_54 有表示之非:夭 飽和雜環，或式G·7〗表· p万曰族雜環，式G-55或式G-56表示之 ^ ^ ^ ^ 〜 示之環烷基環： 36 314918 200407073 R5
R5
Rfia G-7
Rfib
R5
R5
R5
R5
R5
R5
RS
R5 I
R5
/'TV r6c N II n’、r6c r6c G-53
37 314918 200407073
G-55
G-71 W1及W2表示氧原子 X表示鹵素原子、硝基、c“烷基、c&quot;鹵代烷基、 c]-0烷氧基、Cw鹵代烷氧基、C16烷硫基、Ci 6鹵代烷硫 基' CVA亞㈣基' cK6 ώ代燒亞伽基、&amp;.6烧續酿基 或C&quot;鹵代Μ酸基’ m表示2或3 _，各個乂可彼此相 同或相異’ 行丨饮、I月况，可藉由鄰接 再者，在 …w nr *3文〜i I印八71夕力乂- 0CF20 -或- 0CF2CF20_，且鱼夂伽 ό 14各個所鍵結之碳原子共同形成 5員環或6員環； 又’ G表不以式G · 1、r 、〇 i 式 G-4、式 G_5、式 G_6、式 G-7、式 G-8、式 G-11、式 G_12、^ z 式 G-13、式 G-14、式 G-15、式 G-17、式 Gl8 _jb ^ . 式 &amp;18、式 G_21、式 G 22、式 n 式 G-32、式 G-33、式 Πζΐη ^ 式 G-40、式 G_41、式 g_42 或式G-54之任一者表 ° 矛不之非方香私雜環時，χ另 N(R17)R16 ； 』表不- Y表示_素原子 烧基、c1-s：j：完氧基（Ci 表示2或3時，各個 R1表示氫原子； 、Cw烷基、C16鹵代烷基、羥基（^ ) 3)烷基、Cl_6烷氧基或C】-6烷硫基:二 γ可彼此相同或彼此相異； R2表示 氫原子、c
烷基'Cl·4烷氧基（C1·4)烷基或C 314918 38 200407073 少市基， R3表示CY8烷基、被任意取代之（Ci 8)烷基、Cy 環烷基、c3_8烯基、Ci 6烷胺羰基（C3 6)烯基、可被π、！ 取代之苯基（cs_6)烯基、Cw炔基、可被（ζ1)ρι取代之苯基 (Cw)炔基、萘-1-基炔基、萘炔基、（L_ l)-(c3.6)炔基、（L_2)_(C3 6)炔基、（LdHCw)炔基、（L_4)_ (C3_6)炔基、（L45HC3_6)炔基、（L_46)_(C3 6)炔基、（L_47) -(C3_6)炔基、M-4、M-5、m-8、M-9、M-13 至 M-19、M-21 或M-22,或者表示藉由…與R3 一起形成Ch伸烷基鏈並 與鍵結之氮原子共同形成之3至7貝冑，此時之伸烧基鏈 可含有1個氧原子或硫原子； R4表示氫原子、Cl.6烷基、Ci 6 _代烷基、c“環烷基 (CV4)烷基、C3-6鹵代環烷基（Ci 4)烷基、Ci 4烷氧基（CM) 烷基、Cw鹵代烷氧基（Ci·4)烷基、Ci_4烷硫基（u烷基、 Cw鹵代烷硫基（c】·4)烷基、Ci·4烷亞磺醯基（Ci_d烷基、q ^ 鹵代烷亞磺醯基（Cb4)烷基、Ci_4烷磺醯基（C1_4)烷基、C1 鹵代烷磺醯基（Ci·4)烷基、氰基（Ci_6)烷基、Ci_4鹵代烷氧基 (C】·4)鹵代烷基、C3_8環烷基、c3 8鹵代環烷基、 NOR&quot;、-C(R&gt;NORi】、可被（ζ2)ρΐ取代之笨基、丨_萘基、 2-萘基、L_1 至 L-4、L-8 至 L_13、L_15 至 L_23、L 25 至 L-35、L-37、L-38、L-40、L-43 至 L_58、M_4、m_5、 8、M-9、M-14 至 M-18 或 M-19 ; 又，G為以G-7 1表示之環烷基環時，R4可以另外表 不鹵素原子、c&quot;烷氧基、Ci 6鹵代烷氧基、c“烷硫基 3M918 39 200407073 c〗_6 i代烧硫基、ci 6烷亞磺醯基、Ci 6鹵代烷亞磺醯基、
Cl·6烷磺醯基或cK6鹵代烷磺醯基、 R5 (a)G為以式g_4、式g_5、式g-6、式G-7、式G-8、式 G-U、式 G-12、式 G-13、式 G-14、式 G-15、式 G-17、式 G_18、式 G-21、式 G-22、式 G-23、式 G-32、式 G-33、 式G_40、式G-41、式G-42、式G-53或式G-54之任一者 表不之非芳香族雜環，或以式G-55或式G-50表示之飽和 雜環時，R5表示氫原子、^素原子、氰基、Ci6烷基、Ci6 鹵代烷基、C3-6環烷基（Cw)烷基、Cm鹵代環烷基（Ci 4) 烷基、Cl-4烷氧基（ci·4)烷基、C1-4鹵代烷氧基（ci 4)烷基、 cv4烷硫基（Cl.4)烷基、Ci 4 _代烷硫基（Ci 4)烷基、Ci 4烷 亞石戸、基（C!_4)燒基、cl 4鹵代烧亞石黃醯基烧基、 烷％ fe基（C!·4)烷基、Ci_4鹵代烷磺醯基（u烷基、氰基 (cv6)烷基、〇3.8環烷基、c3-8鹵代環烷基、c】6烷氧基、 6-6鹵代烷氧基、可被（zl)pl取代之苯氧基、c^烷硫基、 q-6 _代烷硫基、可被（21)151取代之苯硫基、烷亞磺醯 基、C]·6 _代烷亞磺醯基、可被（ζ】)ρι取代之笨亞磺醯基、 C】·6烷磺醯基、Cw i代烷磺醯基、可被（Z1)P1取代之苯碏 醯基、C】·6烧胺基、二（Cj·6烧基）胺基、[]&amp;σ各燒_1_美、口四 唑烷-3-基、噻唑烷-3-基、哌啶-1-基、嗎福啉基、_c(〇) -C(0)0R^ -C(0)SR^.C(0)N(R^)R9_C(S)N(r1〇)r9 ^ -CH=NORH、-C(R9)=N0R11、可被（Z2)P1 取代之笨基、卜 萘基、2 -萘基、L或Μ ; 314938 40 200407073 (b)G為以G-71表示之環燒基，且R4表示氫原子、由素原 子、C!·6烷基或C&quot;鹵代烷基時，R5表示氰基、q罈严 基（c】_4)烷基、Cw鹵代環烷基（Ci_4)烷基、烷氧基（q 4)烷基、Cw _代烷氧基（c^4)烷基、c】_4烷硫基（c】J烷基、 匸“齒代烷硫基^“^烷基^以烷亞磺醯基^^燒4^、^“ 鹵代烷亞磺醯基（Cw)烷基、Ci_4烷磺醯基（Ci 4)烷基、Cl 4 鹵代烷磺醯基（C】·4)烷基、氰基（Ci_6)烷基、環烷基、 C3·8函代環烷基、可被（zl)pi取代之苯氧基、可被π】）ρΐ取 代之苯硫基、可被（ζ1)^取代之苯亞磺醯基、可被（ζΐ)Ρρΐ取 代之苯磺醯基、-CHO、-C(0)R9、_c(〇)〇R9、、 -C(0)N(R1G)R9、-C(S)nhrio、c(s)n(r1())r9、韻⑽】、 -C(R9)=NORH、-Si(R13)(Ri4)Ri2、可被（Z2)pi 取代之苯基、 1-萘基、2-萘基、L或μ ; (c)G為以G-71表示之環烷基，且R4表示C36環烷基（c“) 烷基、CM齒代環烷基（Ci_4)烷基、Ci·4烷氧基（Ci 4)烷基、 CV4鹵代烷氧基（c】_4)烷基、Ci_4烷硫基（Ci·4)烷基、c】_4鹵 代烷硫基（Ch)烷基、Cl_4烷亞磺醯基（Ci·4)烷基、Ci 4 _代 烷亞磺醯基（C】—4)烷基、Ci·4烷磺醯基（Ci·4)烷基、_代 烷磺醯基（c^)烷基、氰基（Ci 6)烷基、Ci 4鹵代烷氧基（c^) 鹵代烷基、Cw環烷基、cs_8鹵代環烷基、ci6烷氧基、 鹵代烷氧基、烷硫基、Cw ii代烷硫基、C16烷亞磺醯 基、C〗.6 ii代烷亞續fe基、Ci·6烷績醯基、函代烷磺醯 基、可被（Z2)p】取代之笨基、1-萘基、2_蔡基、至L-4、 L-8 至 L-13 、 L-15 至 L-23 、 L-25 至 L-35 、 L-37 、 L-38 、 314918 41 200407073 L-40、L-43 至 L-58、H M-5、M-8、M-9、M-14 至 Μ- 18或M-19時，R5表示氳原子、鹵素原子、氰基、c“烷 基、c&quot;鹵代烧基、c3 6環烷基（c&quot;)烧基、_代環烷 基（Cw)烷基、CM烷氧基（Ci 4)烷基、鹵代烷氧基 J烷基、Cw烷硫基（u烷基、Ci 4鹵代烷硫基（Ci 4)烷基、 (:^烷亞磺醯基^^“烷基〜匕^鹵代烷亞磺醯基^^烷 基、c]·4烷磺醯基（u烷基、Ci 4鹵代烷磺醯基（Ci 4)烷 基、氰基（Cw )烷基、c3_8環烷基、C3 8鹵代環烷基、ci 6 烷氧基、C!_6鹵代烷氧基、可被（zl)取代之苯氧基、C 烷硫基、Cw鹵代烷硫基、可被（ζ1)ρΐ取代之苯硫基、ci 6 烷亞磺醯基、Cu鹵代烷亞磺醯基、可被（ζι)ρΐ取代之苯亞 磺醯基、烷磺醯基、cK6鹵代烷磺醯基、可被（z1)^取 代之苯磺醯基、-CHO、-C(0)R9、-C(C〇〇R9、-C(C〇NHR10、 -C(0)N(R1G)R9、-C(S)NHR1G、-C(S)N(R1Q)R9、-CH=NORu、 -C(R9)=NORn、-Si(R13)(RI4)R12、可被（z2)pl 取代之苯基、 1-萘基、2-萘基、L或Μ ; R6a、R6b、R6c及R6d各自獨立，表示氫原子、鹵素原 子、氰基、Cw烷基、C】_6鹵代烷基或可被（z2)p]取代之笨 基； R6e表示氫原子、cv6烷基、（^.6烷磺醯基、c]_6鹵代 烷磺醯基、可被（ζι)ρ1取代之苯磺醯基、Cl 6烷羰基、c^6 鹵代烷羰基、可被（z])pl取代之苯羰基、Cw烷氧羰基、c1-6 鹵代烷氧羰基、可被（z])pl取代之苯氧羰基、二（C,.6烷基） 磷醯基或可被（z2)pl取代之苯基； 42 314918 200407073 、R6g及R6h各自獨立，表示氫原子、Ci 6烷基、c]_ 鹵代烧基或可被（z2)pl取代之苯基， R61表示氫原子、鹵素原子、氣基、C】_6烧基、（^_6鹵 代烷基、C1-6烷氧羰基或Cw鹵代烷氧羰基； R6j及R6k各自獨立，表示氫原子、鹵素原子、氰基、 C1-6烧基或Cudi代烧基； Z2表示鹵素原子、氰基、硝基、胺基、CY6烷基、cv6 鹵代烧基、C1-3烧氧基（C〗_3)烧基、c】_3鹵代：):完氧基（ci3) 烷基、Cw烷硫基（Cl 3)烷基、c1-3鹵代烷硫基（c^)烷基、
Cu烧亞續st基（Cw)烧基、Cw鹵代烧亞續酿基（Cu)：)：完 基、CV3烷磺醯基（(^_3)烷基、cN3鹵代烷磺醯基（Ci_3)烷
基、氰基（C1-0)烧基、c3-8環烧基、c3_8鹵代環烧基、c, A 1-6 烷氧基、鹵代烷氧基、Cis鹵代烷氧基（Ci3)鹵代烷氧 基、c^6烷磺醯氧基、Cw鹵代烷磺醯氧基、可被（21)131取 代之苯氧基、-0(L-45)、〇】_6烷硫基、Cl.6 IS代烷硫基、c 3-8 環烷硫基、Cw烷亞磺醯基、c】_6鹵代烷亞磺醯基、 環烷亞磺醯基、c】_0烷磺醯基、Ci 6鹵代烷磺醯基、Cu 裱烷磺醯基、c】_6烷胺基、二（Ci 0烷基）胺基、Cw烷胺磺 醯基、二（Cl_6烷基）胺磺醯基、_c(〇)Nh2、烷胺羰基、 二（Cw烷基）胺羰基、-C(S)NH2或三（c】_6烷基）矽烷基，w 表示2以上之整數時，各個Z2可彼此相同或相異； 再者在2個Z鄰接之情況，可藉由鄰接之2個汐形成 -〇CF^·並與各個所鍵結之碳原子共同形成5員環； R表不C]-6烷基、C]·6鹵代烷基、可被（z])pi取代之笨 334918 43 200407073 基（Cl·4)烷基、Cw環烷基、或可被（z1)^取代之笨基； R 10 矣- 土 衣不氫原子或Cw烷基，或者藉由…與Rl〇 一起 开y成Cw伸烷基鏈，並與鍵結之氮原子共同形成5員環或 6員％ ’此時之伸烷基鏈可包含1個氧原子或硫原子； + R]1表示Cw烷基、Cl·6 A代烷基或可被（ζι)ρΐ取代之 苯基（Cl·4)烷基，或者藉由R9與R11 —起形成c2_3伸烷基 鏈’並與鍵結之原子共同形《5員環或6員環，此時之伸 烧基鍵可被cK6烷基任意取代； &amp;15表示烷基或可被（z1)^取代之苯基； R16☆表示氫原子、Cw烷基、C】_4烷氧基（Cl_4)烷基、 C&quot;烧硫，（cK4)院基、_CH〇、Ci 6烧戴基、u代烧幾 基、cs_6環烷羰基、Ci_6烷氧羰基、cw函代烷氧羰基或 (V6烷硫羰基； 表示·SL原子或Cu烧基，或者R17與r2可一起形 成-CH2-。 y R18表示i素原子、氰基、c3 6環烧基、_or28、_n(r29) R28、_S(0)rR3G、Ci 6 烷氧羰基、_c(〇)n(r32)r31、= NOH、-C(R34) &gt;n〇r33、三（CV4 烷基）矽烷基、可被（zi)p] 取代之苯基、Ι_1、L-2、L-3、L-4、L-45、L-46、L-47 戍 M ; R25表示ch4烷基； R26表不c】4烷羰基或c16烷氧羰基； R28表不氫原子、Cw烷基、Ci·6鹵代烷基、c】4烷氧 基（c】·4)烷基、Ci_4烷硫基（c】·4)烷基、可被（以^取代之苯 314918 44 200407073 基（u烷基、C〗·6烷羰基、c3 0環烷羰基、Cw烷氧羰基、 -c(o)N(R32)R31、〇]_6烷磺醯基、二（Ci 6烷基）胺磺醯基、 可被代之笨磺醯基、二（Ci6烷基）磷醯基、二（Ci_6
烷基）硫代磷醯基、三（Ci 4烷基）矽烷基或可被（ζ1)Μ取代之 苯基； P R29表示氫原子或Ci6烷基； 表不c1-6烷基、c】_6鹵代烷基、羥基（u烷基、 CV4烷氧基（Cw)烷基、Ci 4烷硫基（U烷基、Cl&quot;烷羰基 (U烷基、烷氧羰基（Ci_4)烷基、二（Cw烷基）胺羰基 (Cl·4)院基 一（Cl-4院基）石夕烧基（CK4)烧基、可被（z1)^取 代之苯基（C〗·4)烷基、Cs_0烯基、c36炔基、C&quot;烷硫基、 可被（Z%】取代之苯基、L-21或L-45 ; R31表示cK6烷基、Ci4烷硫基（Ci4)烷基、可被（zl)pi 取代之苯基（Cw)烷基、CM環烷基、C3 6烯基或可被（zl)y 取代之苯基； R表不氫原子或Cw烷基，或者表示藉由尺31與R32 一起形成C2·5伸烷基鏈，並與鍵結之氮原子共同形成之3 至6員環，此時之伸烷基鏈可含有丨個氧原子或硫原子； R”表示c】·6烷基或可被（z】）pi取代之苯基（Ci 4)烷 基； R。4表示氫原子或Ci_6烷基； m表示0至3之整數； n表示〇至3之整數； q2表示〇至3之整數； 314918 45 200407073 q3表示0至2之整數；以及 q4表示0至2之整數。 [4]上述[3]之取代苯（甲）醯苯胺化合物或其鹽，其 中： G表示以式G-4、式g_5、式G_6、式G_7、式G_u、 式 G-13、式 G-14、式 G_l5、式 G_17、式 G」8、式 〇_21、 式G-22或式g-23之任一者表示之非芳香族雜環，或式 G-71表示之環烷基環； X表示鹵素原子、硝基、Ci4烷基、CY4i|代烷基、 CV4烷氧基、Cw ii代烷氧基、Ci 4烷硫基、_代烷硫 基、C〗_4院亞磺S&amp;基、CK4鹵代烷亞磺醯基、Cl 4烷磺醯基 或Cw i代烧磺醯基，m表示2時，各個X可彼此相同或 相異； Y表示鹵素原子、cK4烷基、Cl 4鹵代烷基、Cl_4烷氧 基或C! ·4烷硫基，η表示2或3時，各個Y可彼此相同或 彼此相異， R2表示氫原子或CK6烷基； R3表示C】_8烷基、被R]8任意取代之（Ci 8)烷基、Gy 烯基或C3_8炔基； R4表示氫原子、CN6烷基、CV6鹵代烷基、C3_6環烷 基（Cle4)烧基、C!_4烷氧基（U烷基、cle4鹵代烷氧基（c]_ 4)烷基、Cw烧硫基（&lt;^·4)烧基、c14鹵代烧硫基（Cl_4)烷基、 c3.8環烷基、〇3_8鹵代環烷基、可被（z2)pl取代之苯基、2-萘基、L-1 至 L-4、L-15 至 L-17、L-19、L-20、L-22、L- 46 314918 200407073 M-8 - M-9 &gt; M-14
23、L-45 至 L-47、L-50、VM、M 至 M-18 或 M-19 ; 又’ G為以式G-71表示之環烷基環時 R4可以另外 表示鹵素原子、cle6 C ^ _ 6 _代院硫基、C R5 元氧基代烷氧基、CY6烷硫基 i·6烷、fe基或C1_6齒代烷磺醯基； ⑷G為以式G-4、式G-5、式匕6、式G-7、式G_n、式 G-13、sG-14、^G_15n17n18m 式G-22或式G-23之任一者表示之非芳香族雜環時，…表 示氫原子、i素原子、氰基基、㈣基、 C：3-6環烷基（Cw)烷基、C〗_4烷氧基（Ci 4)烷基、鹵代烷 氧基（Ch)烷基、Cw烷硫基（Ci_4)烷基、Ci 4 _代烷硫基 (Cm)烷基、Ch烷亞磺醯基（Ci·4)烷基、Ci 4鹵代烷亞磺醯 基（CV4)烷基、CV4烷磺醯基（Ci_4)烷基、Cw _代烷磺醯基 (C〗-4)烷基、C3·8環烷基、cs_8鹵代環烷基、烷氧基、 鹵代烷氧基、Cw烷硫基、Ci 6鹵代烷硫基、Cw烷亞 磺醯基、Cw鹵代烷亞磺醯基、Ci 6烷磺醯基、C1_6鹵代烷 石頁&amp;&amp;基、一（c!·6烷基）胺基、吡咯烷_丨_基、嘿唑烧_3•基、 喧σ坐烧-3-基、脈11疋-1 -基、嗎福n林基、、 可被（Z2)pl取代之苯基、1-萘基、2·萘基、L、M_4、M_5、 Μ - 8、Μ - 9、Μ -1 4 至 Μ -1 8 或]VI -1 9 · (b)G為以G-71表不之環烷基環，且R4表示氫原子、鹵素 原子、c】·6烧基或c】_6鹵代烧基時，R5表示c3 6環烷基（Ci 4) 烷基、c】·4烷氧基（c】_4)烷基、c】4鹵代烷氧基烷基、 314918 47 200407073
Gy烷硫基（C]_4)烷基、Cm ^代烷硫基（c〗_4)烷基、[Η烷 亞磺醯基（Cl_4)烷基、Cw鹵代烷亞磺醯基（Cl_4)烷基、Ch 烷磺醯基（C】·4)烷基、Ci·4齒代烷磺醯基（c】·4)烷基、C3 8環 烷基、C3.8 鹵代環烷基、_c(r9)=n〇r&quot;、-叫r13)(r&quot;)r】2、 可被（Z2)pl取代之苯基、萘基、2_萘基、L、、M巧、 M-8、M-9、M-14 至 M-18 或 M-19 ; (C)GfU G_71表示之環烷基環，且R4表示Cs6環烷基 (一 I-4)少兀土 c】-4垸氧基（c^)烧基、Cw鹵代烧氧基（c〖 烷基、Ch烷硫基（C]·4)烷基、Ci·4 _代烷硫基（(^4)烷基、 C3-8環烷基、（：3·^代環烷基、Ci·6烷氧基、Ci 6鹵代烷氧 基、Cw烷硫基、Ci·6鹵代烷硫基、Ci·6烷磺醯基、Cw鹵 代烷磺醯基、M-4、M-5、M-8、M-9、M-14 至 M-18 或 M-19 時’ R5表示氫原子、鹵素原子、氰基、C&quot;烷基、函 代烷基、c3_6環烷基（Ci 4)烷基、Ci 4烷氧基（Ci 4)烷基、 鹵代烷氧基（Cw)烷基、Ci_4烷硫基（Ci 4)烷基、鹵代烷 硫基（Cw)烷基、c]_4烷亞磺醯基（Ci 4)烷基、鹵代烷亞 石戸、I基（C^4)烷基、C]_4烷磺醯基烷基、匚1_4鹵代烷磺 fe基（C】·4)烷基、C:，·8環烷基、Cw鹵代環烷基、Cw烷氧 基、c]·6鹵代烧氧基、C&quot;烧硫基、c] j鹵代烧硫基、 烷亞磺醯基、Cw函代烷亞磺醯基、Ci 6烷磺醯基、Cw 鹵代烷磺醯基、.C^Rq-NOR11、-Si(R】3)(Ri4)R】2、M-4、 M-5、M-8、M-9、M-14 至 M,18 或 M-19 ; (d) G為以式G-71表示之環烷基環，且R4表示可被（Z2)p】 取代之笨基、1-萘基、2_萘基、至L^、L_】5至L_n、 314918 48 200407073 L-19、L-20、L-22、L-23、L-45 至 L-47 或]_5〇 時，r5 表 示氫原子、鹵素原子、氰基、c&quot;烷基或cK6鹵代烷基； R6a、R6b、R6e及R6d表示氫原子； R表示c】-6：j：完基、c1-6烧石黃基、Cl6燒氧幾基、二 (C1·6烷基）磷醯基或可被（Z2)pi取代之苯基； R61表示氫原子、鹵素原子或c!_6烧基； R6j及R6k各自獨立，表示氫原子、鹵素原子、氰基戋 甲基； 月土〆 R9表不Cu烷基、c]_6鹵代烷基、C3_8環烷基、或可 被（z1)^取代之笨基； R11表示C〗·6烷基或C&quot;鹵代烷基，或者表示藉由R9 與R11 —起形成Cw伸烷基鏈，並與鍵結之原子共同形成 之5員環或6員環，此時之伸烷基鏈可被Ci 6烷基任意取 代； &quot; R18 表示-OR28、-N(R29)R28、-s(0)rR30、-C(R34)=n〇H、 -C(R34) =NOR33或可被（zl)p]取代之苯基； R28表示氫原子、Ci_6烷基、Gw烷羰基、Cw烷氧羰 基、Cl·6烷胺羰基、cs·6環烷胺羰基、二（Cw烷基）胺羰基、 可被（冗”…取代之笨胺羰基、可被（zl)p】取代之笨基（Cw) 烷胺羰基、Cw烷磺醯基、二（c〗 6烷基）硫代磷醯基或可被 (Z1)&quot;取代之苯基； R30表不CV0烷基、c】·6烷硫基、可被（ζ】）ρι取代之笨 基或L-45 ; R33表示CV6烷基； 49 314918 200407073 R34表示氫原子； m表示0至2之整數；以及 η表示〇至2之整數。 [5]上述[1]至[4]之取代Ν-苯（甲）酿苯胺化合物或其 鹽，其中： G為以式G- 4 式G-11、式 式 G-5、式 G-6、式 G-7、 G-13、式 G-14、式。15、式 G]7、式 G]8、式 G 2i、 式G_252或式G_23之任一者表示之非芳香族雜環； R表不Gw%烷基（Ci_4)烷基、Ci4烷氧基do烷基、 Cm鹵代烷虱基（Ch)烷基、烷硫基（Ci_j烷基、〔η鹵 代烧硫基（Cw)烧基、Ci·4烷亞磺醯基π&quot;)烷基、[Μ鹵代 烷亞磺醯基（Ch)烷基、Ci]烷磺醯基（Ci 4)烷基、函代 烷磺醯基（Cl·4)烷基、環烷基、C3_8 _代環烷基、吡咯 烷小基、噚哇烧-3-基、噻唾烧-3_基、哌唆小基、嗎福啉 -1-基、-c(r9)=nori】、可被（Z2)pi取代之苯基、丨_萘基、2· 奈基、L、M-4、M-5、M-8、M-9、M-14 至 M-18 或 M-19。 [6]上述[1]至[4]之取代N-苯（甲）醯苯胺化合物或其 鹽，其中： G為以式G-4、式G-5、式G_6、式匕7、式G_u、式 G-13、式 G-14、式 G-15、式 G-17、式 G-18、式 G-21、 式G-22或式G-23之任一者表示之非芳香族雜環； R4表示Cw環烷基（Cl_4)烷基、Ci4烷氧基（Ci4)烷基、 c】4鹵代烷氧基（C】 4)烷基、c14烷硫基（c】_4)烷基、4鹵 代烷硫基（Cw)烷基、C：3 8環烷基、c3 8函代環烷基、可被 314918 50 200407073 (Z2)pl取代之苯基、2-萘基、L-1至L-4、L-15至Ul7 τ L、19、 L-20、L-22、L_23、L-45iL-47、L-50、M_4 3 8、M-9、M-14 至 M-18 或 M-19。 [7]上述[1]至[3]之取代N-苯（甲）醯苯胺化合物 ^ 或其之 鹽，其中：
G為以式G-4、式G-5、式G-6、式G-7、式G G-13、式 G-14、式 G-15、式 G-17、式（M8、斗 式 ^ G-21 式G-22或式G-23之任一者表示之非芳香族雜譬·
R3表示CY8烷基、Cl 8鹵代烷基、氰基（c m 1'8)現基、C 壞燒基（CV8)烧基、三（Cw烧基）石夕烧基（cl s)垸烏 3'6 (z )P1取代之笨基（C卜8)烧基、（L-l)- (C&quot;)垸基、（L 2 °被 烷基、（1^3)-((^.8)烷基、（L_4)_(Ci-8)烷基、（L_45) )、（CV8) 烷基、（1^46)-((^.8)烷基、（L_47)_(Ci 8)烷基、c s(Ck8) ^ - 8 vJ&amp; -a* c3-8烯基、可被（zi)p】取代之苯基（C3 6)烯基、c 、 土、 ，取代之苯基(c“)快基、萘-1切3·^ 基（C3-6)炔基、（L-lHc3 6)炔基、（L_2MC3 6)炔 本-2- (Cs-6)炔基或α-47)·υ炔基，或者藉由κ2Ά、3 成C2·6伸烷基鏈並與鍵結之氮原子共同、 .[8]上述[4]之取代Ν-苯（曱）醯苯胺化合物或至其 (C3-6)炔基、（L_4)-(C3-6)炔基、（L-45)-(C3 6)炔義&quot;、、（L〇)' (C3·,)快基或（L-47WC，，、执 I，土土 、一、土、(L_46)' 起形 I環 ，其 G 為以式 g_4、4 jb ^ ^ 式 G-5、式 G-6、式 g_7、 G-13、式 G，14、式 Γ 1 ς p 1、j 式 G-15、式 G-17、式 G i8 式G-22或式〇_23之 式G-21、 之非方香族雜環；以及 314918 51 200407073 V表示Cw烷基、可被（ζι)ρ〗取代之苯基（Ci8)烷基、 c3_8浠基或c3.8炔基。 [9]上述[1]至[3]之取代N-苯（甲）醯苯胺化合物或其 鹽，其中： G為以式G-4、式G-5、式G-6、式G-7、式G-11、式 G-13、式 G_14、式 G-15、式 G-17、式 G-18、式 g_21、 式G-22或式G-23之任一者表示之非芳香族雜環； R3表示被Ris任意取代之（Ci 8)烷基、Ci 6烷胺羰基 (U烯基、14、M-5、M-8、M-9、M-13 至 M-19、M-21 或Μ 22’或者可藉由R2與R3 一起形成包含1個氧原子或 ’IL原子之C 2 _6伸烧基鍵，並與鍵結之氮原子共同形成3至 7員環； R4表示氣原子、C&quot;烷基或c】_6鹵代烷基； R表不氣原子、鹵素原子、氰基、cv6烷基、cv6鹵 代烧基、cKe烷氧基、Ci 6鹵代烷氧基、6烷硫基、Cw 鹵代烷硫基、Ci 6烷亞磺醯基、鹵代烷亞磺醯基、Ci_ 6烧石H酷基、Cl-6鹵代烷磺醯基或二（(^_6)烷胺基； R18 表示、〇R28、_n(r29)r28、_s(〇)rR3()、烷氧羰基、 Cl·6 烷胺羰基、-C(0)N(R32)R31、-C(R34)=NOH、-C(R34) = NOR33 或 Μ ; R表示氫原子、Ci 6烷基、Gw鹵代烷基、烷氧 基（CV4)烧基、烷硫基（Cy)烷基、可被（z】）pi取代之笨 基（C】·4)烧基CN6烧獄基、（23.6環：)：完幾基、Cw烧氧獄基、 -C(0)N(R，R3]、C】_6烷磺醯基、二（c].6烷基）胺磺醯基、 52 3149Ϊ8 200407073 可被（冗^^取代之苯磺醯基、二（c]_6烷基）填醯基、二（Cu 烷基）硫代磷醯基、三（Cw烷基）矽烷基或可被（z1)^取代之 苯基； R29表示氫原子或（^_6烧基； R30表示CV6烷基、CY6鹵代烷基、羥基（(γ4)烷基、 CV4烷氧基（Ci-4)烷基、c〗_4烷硫基（c〗_4)烷基、Cb4烷羰基 (C〗·4)烷基、Cw烷氧羰基（cv4)烷基、二（Cw烷基）胺羰基 (Cl-4)烧基、二（Ci_4烧基）秒烧基（C1-4)烧基、可被（Z 1 ) p】取 代之苯基（CV4)烷基、c3_6烯基、c3_6炔基、Cu烷硫基、 可被（Z%〗取代之苯基、L-21或L-45 ; R31表示Cu烷基、cU4烷硫基（C1-4)烷基、可被（zi)y 取代之苯基（&lt;^_4)烷基、c^6環烷基、c3_6烯基或可被（zl)pi 取代之笨基； R32表示氫原子或Cu烷基，或者可藉由R3i與R32 一 起形成Cm伸烷基鏈，並與結合之氮原子共同形成3至6 員環，此時之伸烷基鏈可含有丨個氧原子或硫原子； R表不C!·6烷基或可被（Ζ”ρι取代之苯基（Ci_4)烷 基， R34表示氫原子或C16烷基； q2表示〇至3之整數； q3表示0至2之整數；以及 q4表示〇至2之整數。 Π0]上述[4]之取代N—苯（甲）醯苯胺化合物或其鹽，其 中： 、I /、 314918 53 200407073 G為以式G-4、式 八、式G-6、式G-7、式G-n、式 G-13、式 G_14、式 g_15、 i：)、式 G-17、式 G-18、式 G-21、 式G-22或式（3-23之任_本主- 1 士 者表不之非芳香族雜環； R 表不被-QR、·Ν(Κ29)κ28、s(〇) r3G、C(r34)=n〇h 或-c(R34)=NOR33任意取代之C&quot;烧基； R4表不虱原子、Cl_6烷基或c&quot;鹵代烷基； R5表示氫原子、ώ素原子、氰基、CV6烧基、ClJ 代烷基、CV6烷氧基、C“鹵代烷氧基、烷硫基、c“ 鹵代烷硫基、Cw烷亞磺醯基、Ci 6 _代烷亞磺醯基、 6烷磺醯基、Cw鹵代烷磺醯基或二（Ci6)烷胺基； R28表示氮原子、Cw烷基、C16烷羰基、Cl_6烷氧羰 基、Ci_6烷胺羰基、C：3·6環烷胺羰基、二（Ci 6烷基）胺羰基、 可被（冗”…取代之笨胺羰基、可被（zl)p!取代之苯基 烷胺羰基、Cw烷磺醯基、二（Ci 6烷基）硫代磷醯基或可被 (Z1)〆取代之苯基； R表示Cu燒基、C】·6烧硫基、可被（^^取代之苯 基或L-45 ; R33表示Cu烷基；以及 R。4表不鼠原子。 [11]上述[1]至[5]或上述[7]至[8]之取代N-苯（曱）醢笨 胺化合物或其鹽，其中： G 為以式 G-7、式 G-13、式 G-14、式 G-15、式 G-17 或式G-1 8之任一者表示之非芳香族雜環； X表示i素原子、硝基、c]_4烷基、Ci一鹵代烷基、 54 314918 200407073 c〗_4烷硫基、Ci_4烷亞磺醯基或Ci4烷磺醯基，m表示2 時，各個X可彼此相同或相異； 丫表不南素原子或ci_4烷基，η表示2時，各個Y可 彼此相同或相異； 表示元基或cN6鹵代烧基；以及 R5表示可被（Ζ2)ρι取代之苯基、卜萘基、萘基、 至 L-5 、 L-8 至 L-24 、 L-28 至 L-36 、 L-39 、 L-41 、 L-42 、 L-45 至 L-47 或 L-50 。 [12]上述至[4]或上述[6]至[8]之取代N-苯（甲）醯苯 胺化合物或其鹽，其中·· G 為以式 G-7、式 G-13、式 G-14、式 G-15、式 G-17 或G-18之任一者表示之非芳香族雜環； X表不鹵素原子、硝基、c】_4烷基、Cl 4鹵代烷基、 C】_4烷硫基、Cl_4烷亞磺醯基或c】_4烷磺醯基，㈤表示2 時，各個X可彼此相同或相異； Y表示鹵素原子或Ch烷基，n表示2時，各個γ可 彼此相同或相異； R4表示可被（Z2)P1取代之苯基、2_萘基、L]至L-4、 至 L 17 L-19 、 L-20 、 L-22 、 L-23 、 L-45 、 L-46 或 L-47 ;以及 R5表示ii素原子、Ci6烷基、q
烷磺醯基或二（cK6)烷胺基。 [13]上述[4]之取代N-苯（曱）醯笨 元基、Cl 6鹵代烧基、Ci.6烧乳 CK6烷亞磺醯基、Cw 胺化合物或其鹽，其 55 314918 200407073 中： G為以式G-7 1表示之環统基環； X表示鹵素原子、硝基、C]-4烷基、c]4鹵代烷基、 C〗·6焼硫基、C!·6烧亞續酸基或Ci 6烷磺醯基，m表示2 時，各個X可彼此相同或相異； Y表示鹵素原子或C!_6烷基，η表示2時，各個Y可 彼此相同或相異； R3 表示被-OR28、-N(R29)r28、-s(0)rR3。、-C(R34)=NOH 或-C(R34)=NOR33任意取代之ci-8烷基； R4表示氫原子、鹵素原子、Cw烷基或（^_6鹵代烷基； R5表示可被（Z2)P1取代之苯基、丨-萘基、2_萘基、Lq 至 L - 4、L -1 5 至 L -1 7、L -1 9、L - 2 0、L - 2 2、L - 2 3、L - 4 5、 L-46 或 L-47 ; R28表示氫原子、Gw烷基、Cle6烷羰基、〇γ6烷氧羰 基、c&quot;烧胺幾基、c3 6環烷胺魏基、二（Ci 6烷基）胺羰基、 可被（冗^…取代之笨胺羰基、可被（ζι)ρΐ取代之苯基（Cy) 烷胺羰基、Cw烷磺醯基、二（Ci 6烷基）硫代磷醯基或可被 (Z1)^取代之苯基； R·30表示CN0烷基、Ci·6烷硫基、可被（21)^取代之笨 基或L-45 ; R3。表示Ci·6烷基；以及 R34表示氫原子。 [14]上述[4]之取代n-笨（曱）醯笨胺化合物或其鹽，其 中： /、 314918 56 200407073 G為以式G-71表示之環烧基壤’ R4表示可被（Z2)pl取代之苯基、2_奈基、L-1至L-4、 L-15 至 L-17、L-19、L-2〇、L_22、L_23、L-45、L-46 或 L-47 ;以及 R5表示氫原子、鹵素原子或C】-6燒基。 [15]上述[14]之取代N-苯（甲）酸苯胺化合物或其鹽， 其中： X表示鹵素原子、石肖基、Ch烧基、cK4鹵代烷基、 Cu ；)：完硫基、Cw烧亞磺醯基或（V6垸續酿基，m表示2 時，各個X可彼此相同或相異； 2時，各個Υ可 Y表不鹵素原子或Ci_6烧基，η表示 彼此相同或相異； R5表示氫原子； R6i表示氫原子； R6j及R6k各自獨立，表示氫原子、 [16] —種通式（2)或通式（3)表示之n 酞醯亞胺或取代苯胺基或彼等之臨 ’眾于、ii素原子或氰基。 示之N-取代苯基-3-硝基 R4 R5
[式中： 314918 57 200407073 G 表示式 G-4、式 G-5、式 G-7、式 G-ll、式 G-13、 式G-14、式G-15、式G-17、式G-18或式23之任一者表 示之非芳香族雜環，或者式G-71表示之環烷基環：
R4 R6i a^r5 R5
G-18
G-71 y1代表鹵素原子、CV6烷基、CV6鹵代烷基、羥基（CV6) 烷基、cv3烷氧基（Cy)烷基、CV6烷氧基、CV6鹵代烷氧 基、烷硫基或Cb6 i代烷硫基； Y2代表鹵素原子、CP6烷基、烷氧基或（^.6烷硫 基，nl表示2時，各個Y2可彼此相同或相異； R4， (a)G 為以式 G-4、式 G-5、式 G-7、式 G-11、式 G-13、式 G-15、式G-17、式G-18或G-23之任一者表示之非芳香族 雜環時，R4表示CV6烷基、CK6鹵代烷基、C3_6環烷基（cv4) 58 314918 200407073 I基、Cl·4烷氧基（C]-4)烷基、Cl-4鹵代烷氧基（q ο烧基、 Cl_4烷硫基（Cl-4)烷基、鹵代烷硫基（Ci 4)烷基、c烷 亞只酉皿基（Ci·4)烧基、C卜4鹵代烧亞石黃酿基（q 4)燒芙、匸 烷磺醯基（c^4)烷基、Cl·4齒代烷磺醯基（Ci_4)烷基鹵4 代烷氧基（Cm)齒代烷基、CM環烷基、C38_代環烷y、 Q、卜萘基、2-萘基、L-1 至 L-4、L-8 至 L-13、L-15 至 L-23、 L-30 至 L-35、L_45 至 L_53、M_4、M_5、M 8、M 9、m_ 14 至 M-18 或 M-19 ; (b) G為以式G-14表示之非芳香族雜環時，R4表示c 函 代烷基、c3_6環烷基（c1-4)烷基、cN4烷氧基（Ci 4)烷基、* 鹵代烷氧基（c^·4)烷基、Cw烷硫基（c^·4)烷基、Ci 4鹵代烷 硫基（C〗·4)烷基、c!.4烷亞磺醯基（Ci_4)烷基、Ci 4鹵代烷亞 磺醯基（Cw)烷基、Cw烷磺醯基（Ci_4)烷基、Ci 4鹵代烷磺 醯基（Cw)烷基、CV4鹵代烷氧基（Ci_4)函代烷基、環烷 基、C3_8鹵代環烷基、Q、卜萘基、萘基、LJ至L_4、 L-8 至 L-13 、 L-15 至 L-23 、 L-30 至 L-35 、 L-45 至 L-53 、 M-4、M-5、M-8、M-9、M-14 至 M-18 或 M-19 ; (c) G為以G-71表示之環烷基環時，R4表示鹵素原子、 1-6 烷基、Cw鹵代烷基、Cw環烷基（Ci 4)烷基、Ci 4烷氧基 (Cw)烷基、cle4鹵代烷氧基烷基、c】_4烷硫基（u 烷基、Cw鹵代烷硫基（υ烷基、Ci 4烷亞磺醯基（u 烷基、Cw i代烷亞磺醯基（Ci4)烷基、烷磺醯基（c^) 烷基、CV4鹵代烷磺醯基（Ci-4)烷基、4鹵代烷氧基（Cw) i代烷基、cs·8環烷基、Cw ^代環烷基、ci 6烷氧基、6 314918 59 200407073 函代烧氧基、ci-6烷硫基、CN6鹵代烷硫基、Cw烷亞磺醯 基、q·6 1¾代烷亞磺醯基、€16烷磺醯基、齒代烷磺醯 基、Q、1-萘基、2-萘基、L-1 至 L-4、L-8 至 L-13、L-15 至 L-23、L-30 至 L-35、L-45 至 L-53、M-4、M-5、M-8、 M-9、M-14 至 M-18 或 M-19 ; R5， (a) G 為以式 G_4、式 G-5、式 g_7、式 G-11、式 G-13、式 G-14、式G-15、式G-17、式G_18或G 23之任一者表示
之非芳香族雜環時，R5表示氫原子、鹵素原子、氰基、C 1-6 烧基 Ci·6鹵代烧基、cs_6環烧基（c1-4)烧基、cl-4燒氧基 (C^)烷基、c14鹵代烷氧基（Ci 4)烷基、Ci 4烷硫基（U 烧基 Ci·4鹵代烧硫基（C!·4)烧基、（^_4烧亞磺醯基（c】4) 烷基、鹵代烷亞磺醯基（Ci4)烷基、烷磺醯基（c“4) 烧基、Ch _代烷磺醯基（Ci 4)烷基、c3 8環烷基、c3 8鹵 代％烷基、Cw烷氧基、CY6鹵代烷氧基、c]6烷硫基、ci6 鹵代烷硫基、C】-6烷亞磺醯基、ci 6 _代烷亞磺醯基、Cl 6烷磺醯基、Cw函代烷磺醯基、二（Ci 6烷基）胺基、吡咯 烷_1_基、噚唑烷-3-基、噻唑烷基、哌啶_丨_基、嗎福啉 + 基、-C(R&gt;N0Rn、Q、i 萘基、2 蔡基、L、M 4、M 5、 M-8、M-9、M-14 至 M-18 或 M-19 ; (b) G為以式G-71表示之環烷基環，且R4表示鹵素原子、 (^6沅基或（：1_6鹵代烷基時，115表示（：36環烷基（(：14)烷 基、c】_4烷氧基（c】_4)烷基、4鹵代烷氧基烷基、Cy 烷硫基（c】·4)烷基、Cl·4鹵代烷硫基（Cw)烷基、烷亞磺 314918 60 200407073 酉&amp;基（C〗_4)烧基、C】·4鹵代烧亞石黃酿基（c〗_4)烧基、c〗4燒石备 醯基（C】_4)烷基、Cw鹵代烷磺醯基（Ci_4)烷基、c3 8環烷 基、C3_8 il 代環烷基、-C(R9)=N〇Rll、_Si(Rl3)(Rl4)Rl2、Q、 h萘基、2-萘基、L-1 至 l_4、L-8 至 L-13、L-15 至 L-23、 L-30 至 L-35、L-45 至 L-53、M-4、M-5、M-8、M-9、 14 至 M-18 或 M-19 ; (c)G為以式G-71表示之環烷基環，且R4表示Gy環院基 (Cw)烧基、Cw：)：完氧基（c14)烧基、c1-4鹵代烧氧基（Cu) 烷基、Cm烷硫基（u烷基、CV4鹵代烷硫基（c“4)烷基、 Ci_4烷亞磺醯基（Ci·4)烷基、C! — 4鹵代烷亞磺醯基烷 基、C】·4烷磺醯基（c^4)烷基、Cw鹵代烷磺醯基（ci 4)烷 基、cv4函代烷氧基（Cl_4)鹵代烷基、c3 8環烷基、_ 代環烧基、Cw烷氧基、Cw鹵代烷氧基、c^6烷硫基、 ώ代烧硫基、Cw烧亞磺醯基、cy6 ii代烧亞確醯基、c 1 - 6烧磺醯基、CV6 i代烷磺醯基、]y[-4、M-5、M-8、M-9、 M-14至Μ-18或M-19時，R5表示氫原子、鹵素原子、氰 基、C1-6烧基、Cw鹵代烧基、c3_6環烧基（Cw)烧基、c 1 - 4院氧基（C】_4)烧基、Cl.4 i代烷氧基（C】_4)烷基、Ci 4烷硫 基（Cb4)烷基、C】·4鹵代烷硫基（c]·4)烷基、c1-4烷亞磺醯基 (c】_4)烧基、c】.4鹵代烧亞石頁酉监基（c】_4)烧基、cN4烧石黃酸基 (c〗·4)烷基、CV4鹵代烷磺醯基（c】-4)烷基、c3_8環烷基、c, 3-8 鹵代環烷基、C】-6烷氧基、Cw鹵代烷氧基、〇16烷硫基、 C】_6鹵代烧硫基、Cu烧亞確醯基、C].6 ι|代烧亞續驗基、 C]-6烧石黃醒基、Cu鹵代烧石黃醯基、-C(R9)=NORn、-Si(R13) 314918 61 200407073 (R14)R12、M-4、M-5、M-8、M-9、M_14 至 M-18 或 Μ·19 ; (d)G為以式G-71表示之環烷基環，且R4表示Q、1-萘基、 2-萘基、L-1 至 L-4、L-8 至 L-13、L-15 至 L_23、L-30 至 L-3 5、L-4 5至L-5 2或L-53時，R5表示氫原子、i素原子、 氰基、CV6烷基或CV6 _代烷基； R6a、R6b、R6e及R6d表示氫原子； R6e表示CV6烷基、CV6烷磺醯基、CV6烷氧羰基、二 (C^烷基）磷醯基或Q ; R6i表示氫原子、鹵素原子或Cp6烷基； R6j及R6k各自獨立，表示氫原子、鹵素原子、氰基或 甲基； Q為以下列Q-1至Q-11之任一者表示之可被取代之苯 基··
62 314918 200407073 L為以下列式L-1至式L-58之任一者表示之芳香族雜
L-l L-2 L-3 L-4 (z\2 L-5
(zV N L-11 (Z、4「S L-12
L-13 L-14 R15
(2%4 L-15
L-16 R15
(zV
L-20 (2^4
L 21 L-22 L-23 (Ζ\3rh L-24
R15(zV N L*25
63 314918 200407073 (Z%5 (Z%5 (Z%5 (ZA)ps y°~\ -v L-31 L-32 L-33 L-34 (zV R15 R；5 (Z1)P4 N-N L-36 L-37 L-38 L-39 (¾ (zV R15 N-N N IT R15 N-N, -V L-41 L-42 L-43 L-44 R;5 (Z\5 s—{ N L-35
N V L-40
L-45 L-46 L-47 L-48 L-49
M-4、M-5、M-8、Μ·9、M-14 至 M-18 或 M-19 各表示 下述之飽和雜環： 64 314918 v200407073 M-4 (〇)r (〇)χ M-5
(R25),4?&quot;Ί °
AJ M-14 Μ·15 ,25
(〇)i rs、 M-18 (R'4
M-19 Z1表示齒素原子〜氰基〜硝基〜^^烷基〜^^函代 烷基、Cw烷氧基、Cw鹵代烷氧基、Ci 6烷硫基、6鹵 代烷硫基、C!·6烷亞磺醯基、cK6 _代烷亞磺醯基、 1-0 烷磺醯基、Cb6 胺基，p 1、p 2、 彼此相同或相異 鹵代烷磺醯基、C16烷胺基或二 _ 、1 -6况基） p3或p4表示2以上之整數护， • τ ’各個Z1 w
Z 2 a Z2b及z2d各自獨立，表示鹵素原子、 胺基、烧基 氰基、 硝基、 、Cuiii代烧基、C1&gt;&gt;3烧氧基 C&quot;鹵代烧氧基（c]_3)烧基、Cl_3烧硫基（Cq)燒基、 代烧硫基（C〗·3)烧基、C卜3烧亞石黃酿基（C】-3)燒義 c 烧亞磺醯基（Ci.3)烷基、C〗·3烷磺醯基（c^3)燒義Cl·3 烧石黃酸基（C〗·3)烷基、氰基（C】·6)烷基、Cs.8環 &amp;基、
C •3鹵 鹵代 鹵代 'ίΓ鹵 3】49]8 65 200407073 代環烧基、Cw烷氧基、ci 6 _代烷氧基、Ci 6烷磺醯氧基、 Ci_6鹵代烧磺醯氧基、可被（ζι)ρΐ取代之苯氧基、5_三氟甲 基吡啶-2-基氧、3_氯_5_三氟甲基吡啶-2_基氧、Ci6烷硫 基、C〗·6鹵代烷硫基、c3_8環烷硫基、Cl.6烷亞磺醯基、Cb6 _代烧亞磺醯基、（：3_8環烷亞磺醯基、烷磺醯基、Ch 6 _代烷磺醯基、C3_8環烷磺醯基、c^6烷胺基、二（Cle6烷 基）½基、C1-6烧胺續基、二（cI6烧基）胺續驢基、-c(〇) NH2、C1-6烷胺羰基、二（ci-6烷基）胺羰基、_c(S)NH2或三 (c]_6烧基）碎烧基； 再者，可藉由Z2a與Z2b或者z2a與z2d形成-0CF20-，並各 與鍵結之碳原子共同形成5員環； z2e表示鹵素原子、C1-6烷基或ci-6鹵代烷基； R9表示C&quot;烧基、Ci·6鹵代烷基、c3_8環烷基或可被 (z1)&quot;取代之苯基； R11表示C&quot;烷基或Cw鹵代烷基，或者可藉由&amp;9與 R —起形成C2·3伸烧基鍵’並與鍵結之原子共同形成5 員環或6員環，此時之伸烷基鏈可被CK6烷基任意取代； R”表示烷基或可被（z1)^取代之苯基； R13及R14各自獨立表示Cw烷基； R15表示C】·6烧基或可被取代之苯基； R25表示（^_4烧基； nl表示0至3之整數； P1表示1至5之整數； p2表示0至4之整數； 66 314918 200407073 p3表示〇至3之整數； ρ4表示〇至2之整數 Ρ5表示0或1之整數 q3表示〇至2之整數 q4表示〇至2之整數； r表示0至2之整數；以及 t表不0或1之整數。 Π7] 一種有害生物防治及去除劑，其特徵為 述⑴至叫之N·苯曱Si苯胺化合物及其鹽中選出之 2種以上化合物為有效成分者。 或 Π8] —種農藥，其特徵為含 田林— S ,攸上述[U至[15]之N-笨 曱^本胺化合物及其鹽中選出之丨 有效成分者。 種42種以上化合物為 Π9]—種殺蟲劑或滅虱劑，其特徵為含有從上述[1]至 [15]之N_苯甲醯笨胺化合物及其鹽中選出之}種或2種2 上化合物為有效成分者。 [發明之效果] 由於長年使用殺蟲劑及殺菌劑，近年來病害蟲獲得抵 抗性，因此用先前之殺蟲劑及殺菌劑防止及除去病害蟲變 知困難又’部分毒性咼之殺蟲劑因長期殘留在環境中而 出現擾亂生態系之問題。另一方面，本發明化合物對於多 數辰業告蟲及蟎有優異之殺蟲及殺蟎活性，對於對既存之 殺蟲劑有抗藥性之害蟲可以發揮充分的防止及去除效果。 再者’對於哺乳類、魚類及益蟲大體無不良影響，且為低 314918 200407073 負荷亦輕。 可提供有用 之新穎有害生物之防止與 殘留性，對於環境之 因此’本發明係 去除劑。 【實施方式】 [發明之最佳實施形態] 广/ ^月所包5之化合物中，視取代基之種類，有時 存在E-體及Z-體二種幾何異構物，本發明亦包含此等&amp; 體、z-體或以任意比率包含E_體與z_體之混合物。又，就 本發明所包含之化合物而言’存在因i個或2個以上之不 對稱碳原子之存在所造成之光學活性體，而本發明則包含 全部光學活性體或外消旋體。再者，在以通式⑴表示之本 發明化合物中，R1或R2為氫原子時，視情況存在以下式 表示之互變異構體，而本發明亦包含此等構造。
314918 68 200407073 本發明所包含之化合物中，可以依照習用方法做成酸 、力凰例如氫氟酸、鹽酸、氫漠酸及氫硬酸等氫鹵酸之 鹽’硝酸、硫酸、磷酸、氯酸及過氣酸等無機酸之鹽，甲 八酉文、乙石頁酸、三氟甲磺酸、苯磺酸及對_甲笨磺酸等磺酸 之鹽，曱酸、乙酸、丙酸、三氟乙酸、反丁烯二酸、酒石 酸、草酸、順丁烯二酸、蘋果酸、琥珀酸、笨曱酸、苯乙 醇fee抗壞血酸、乳酸、葡萄糖酸及檸檬酸等緩酸之鹽， 或者榖胺酸及天冬胺酸等胺基酸之鹽。 或者’在本發明所包含之化合物之中，依照習用方法 做成金屬鹽者，例如鉀、鈉及鋰等鹼金屬之鹽，鈣、鋇及 鎮等鹼土金屬之鹽或者鋁鹽。 在本纟兄明書中所式之各取代基之具體例如以下所示。 其中，η-意指「正」，i-意指「異」，s_意指「第二」，^意 指「第三」，以及ph意指「笨基」。 在本發明化合物中，做為G之包含至少i個從氧原 子、硫原子及氮原子中選出之原子且環内存在至少一個雙 鍵之5員或6員非芳香族雜S，例如為以下列式G]至式 G-54等所表示之非芳香族雜環： 3H918 69 200407073
R6d
G-5
κ^?Λ -R5 R5 R4 G-7 G-8
(〇)r
G-17 R5
R5 r6c aN ^R4?、lR5 R6a G-ll R5
R'N R6a G-14 R5 W〈s^^R6b G-18 O Rfib
R5 R4 &quot;sXi R6b
G-20 R6c / R4，N1 R5
N G-21 R5
70 314918 200407073
R5
N
S G-28
R6d
人〇 R5 tR6d，X^'r6c R石这 G^40
R5R6eTA
G4S 71 314918 200407073
在本發明化合物中，做為G之包含2個從氧原子 原子及氮原子中選出之原子之5員或6員飽和雜環， 為以下列式G-55至式G-70等所表示之飽和雜環·· 、硫 例如 R6g T,6h R6h
〇 R5
O G-55 G-56
R6§ 6f
R6h ^iLs Rs R4丫、R
»6f G-60 R5 ^6f
G-59
〇…R5 .0 A (R6)i G-64 G-65 G66
72 314918 200407073 在本發明化合物中， 例如為以下列式G-71至 做為G之3員至6員環烷基環， 式G-78等所表示之環烷基環：
G-71
G-76
G-73 R4 R5
G-75 r4 R5 G-77 G-74
G-78 在本發明化合物φ 氣屌子、皇眉；爲 為鹵素原子者，例如為氟原子、 * . 八原子。又本說明書中之「鹵代（halo) 表不此等之_素原子。 ^兄月曰中之Ca-b烷基表示碳原子數為a至b個之 直鏈狀或分枝鏈狀烴基，其之具體例可列舉如為甲基、乙 基、正丙基、異丙基、正丁基、第二丁基、異丁基、第三 丁基、正戊基、1-甲基丁基、2_甲基丁基、3_甲基丁基、卜 乙基丙基、1小二甲基丙基、i，二甲基丙基、新戊基、正 基〗甲基戊基、2 -甲基戊基、3 -甲基戊基、4_甲基戊基、 1-乙基丁基、2-乙基丁基、二甲基丁基、〗，2-二甲基丁 基、1，3_二甲基丁基、2,2-二甲基丁基、2,3-二甲基丁基、 3’3 一甲基丁基、丨，1，2·三甲基丙基、1，2,2-三甲基丙基、 卜乙基甲基丙基、^乙基甲基丙基、庚基、1-甲基己 基、二甲基戊基、1，1，3-三甲基丁基、辛基、^甲基庚 314918 73 200407073 基、壬基、1-甲基辛基、；[，κ二甲其&amp; # ， Τ基庚基、癸基、基壬 基、十一烷基、1-甲基癸基、十二 嗓 ^ „ 杌暴及1-甲基十一烷基 寻，在各個指定之碳原子數之範圍内選擇。 在本說明書中之c 產代嫁其主一 基表不與碳原子鍵結之氫 原子被鹵素原子任意取代且碳原 斗、\ , 卞数為a至b個之直鏈狀 或分枝鏈狀烴基，此時，被2個 _ 上之鹵素原子取代之愔 況，此等鹵素原子可彼此相 列兴4备田* ;J J相兴。其之具體例可 歹J舉如贶甲基、氯甲基、溴 =氟甲美-… 氟甲基、二氯甲基、 一 iLT暴、二氣甲基、翕—翁 A . 虱一虱甲基、溴二氟甲基' 2_氟乙 基、1-氯乙基!、白 r其&quot; 1乙基、漢乙基、2-漠乙基、2,2_二氟 一 Γ ，-一虱乙基、2,2二氯乙基、2-漠-2-氯乙基、2 2 2_ 二氟乙基、2,2,2-三氯乙基、j &quot; =氟乙A、2、ΐ · ,1，2,2-四氟乙基、2-氯 四氣乙基、丨-氣-1 2 2 2基、五氣乙基、2_氯-1，1,2,2· 基、&amp;二氯氟乙基、2_漠仙 1-氣丙A 2^ 鼠乙基、2,2,2-三氣-1，1-二氟乙基、 1氣丙基、2-氣丙基、3·Λ 乙美2 ^ 1 ”丙土、3-溴丙基、2-氟-1_甲基 乙基、2-虱-甲基乙基、2 ^ ^ Τ 基乙基、2,2,3,3,3-五氟 土、，，2,3,3,3‘六氟丙基 友 七產而其、1 〇 ^ ，2,2·二齓三氟甲基乙基、 土 ，，，2‘四氟小三氟甲基乙基、2-溴-1 1 2 3 3 3 六㈣、4-氯丁基、2_氣] 肩1，丨，2,3,3,3- 甲基乙基、3,3,3 ’ 土乙基、2冬1山二 2,3-二漠甲：甲基丙基、九氣丁基、5_氯戊基、 基己基、十心™ 、土 10 -氣癸基、11-淳十一惊某、19 溴十二烷基等，扃夂义 关卞烷暴12- 口固指定之碳原子數之範圍内選擇。 314918 74 200407073 在本說明書中之經基(Cab)_表示與碳原子鍵結之 氣原子被备基任意取代 八从，厌原千數為a至b個之直鏈狀或 刀枝鍵狀烧基’盆之且㈣々丨 ^ 〃之具體例可列舉如羥甲基、1-羥基乙基、 2 -經基乙基、3 -經基丙其 ？、，一 L丞丙基、2-羥基-1-甲基乙基、4-羥基丁 基、2 -羥基-1，1_二甲基 美、 一 -λ ^ . 土 羥土 - _甲基丙基及6_羥基 土、 。固指定之碳原子數之範圍内選擇。 尸 本兄月奇中之氰基（Ca-b)烷基表示與碳原子鍵結之 =子被氰基任意取代且碳原子數為aΗ個之直鍵狀或 /刀枝鏈狀烷基’其之具體例可列舉如為氰基甲基、卜氰基 乙基、2-氣基乙基、3-·其1 ^ ^ ^ 虱基丙基、丨-氰基-1-甲基乙基、4- 氧基丁基、2 -氰基-11- —甲美^ ^ T基乙基、^氰基-l_甲基丙基及 6_氰基己基等，在各個拮宗 口知疋之石反原子數之範圍内選擇。 在本說明書中之C 主-tUrr* ^ U衣烷基表不碳原子數為&amp;至b個 之環狀烴基，可以形成3昌擇$ &amp;吕了四 σο 〜战*3貝％至ό貝裱之單環或複環構造。 又，各個環可被在指定之碳原子數 反你卞數之乾圍内之烷基任意取 代。其之具體例可列舉如環丙美、 ^ 牛X衣内丞 ^甲基環丙基、2-甲基 玉衣丙基、2，2 -二曱基環兩其、 衣内暴 2,2,3,3-四甲基環丙基、環丁 基、私戍基、1-甲基環成美、2甲|：^丄、# 土衣戍丞甲基裱戊基、3-甲基環戊 基、環己基、1-甲基環己某、2甲茸 衣匕丞2甲基裱己基、3-曱基環己 基、4 -曱基環己基、雙環『2211廣9 I楚 备 又衣庾-2-基寺，在各個指定之 碳原子數之範圍内選擇。 卜在本σ兒月曰中之Ca-b鹵代環烷基表示與碳原子鍵結之 虱原子被*素原子任意取代且碳原子數 烴基’可以形成3員環至6員環之單環或複環料。:， 314918 75 200407073 :衣可被在之碳原子數之範圍内之烧基任意取代， =科之取代可在環構造部位，亦可在側鏈部分，或者 [再者，在被2個以上幽素原子取代之情況， 、、皇、戸 H或相異。其之具體例可列舉如1- ’田衣丙基、2,2-二氯環丙基、2,2_二漠環 甲基環丙基、2,2_二氯小 ，= 衣門丞2,2-一溴_卜甲基環 2气土广，2_二氯_3丄二甲基環丙基、2,2,3,3_四氟環丁基、 己基，2-氯環己基、3_氯環己基、心氯環己基、2_ :虱：基環己基、3_三敗甲基環己基及心三氟甲基環己基 寺，在各個指定之碳原子數之範圍内選擇。 在本5兄明書中之c 橋其# ;八
La_b烯基表不分子内具有1個或2個 二:鍵之碳原子數為個之直鏈狀或分枝鍵狀不飽 和扭基’其之具體例可列舉如乙稀基、卜丙稀基、卜甲基 乙烯基、2-丙烯基、卜丁烯基、】_甲基小丙稀基」·甲基 广丙稀基、2-丁稀基、卜甲基_2·丙稀基、2-甲基-2·丙稀基、 3-丁稀基、丁二稀基、卜甲基_2_ 丁烯基、2_甲基2 丁 :基、3-甲基-2-丁稀基、二甲基丄丙稀基、2_己土稀基、 1基-2-戊烯基' u·二曱基_2_丁稀基、i山三甲基士 丙：：、二甲基_3_丁烯基、2,4_己二烯基、2·庚烯基、 2-辛細基、i•甲基2_庚稀基、2•十—烯基、…十一煉基、 2 一十一細基、II-十二稀基等，在夂個；^ 圍内選擇。 在。们“之唆原子數之範 在本說明書中之Caj代稀基表示與石炭原子鍵結之氣 原子被齒素原子任意取代，1分子内具有i個或2個以上 314918 76 雙鍵之碳原子數為 基。此時，祐 b個之直鏈狀或分枝鏈狀不飽和烴 饥2個以 原子可彼此相同，，、之鹵素原子取代之情況，此等鹵素 烯基、2-溴乙烯爲亦可相異。其之具體例可列舉如2-氯乙 溴-2-丙烯基、丨氯2’2、二氯乙烯基、2,2_二溴乙烯基、3_ 氟甲基乙烯基、2氧氯甲基乙烯基、2_溴-1-甲基乙烯基、卜三 二氟乙烯基、3’3,3-二氟丙烯基、1-三氟甲基-2,2-氯-2-丙烯基、23乳3~2_丙稀基、3,3-二氟_2_丙烯基、3,3-二 4,4-二氟丁烯美 '、二氟_2-丙烯基、2,3,3-三氯-2-丙烯基、 2-丁 烯基、3,3,3_ 土 3,4,4-三氟_3_ 丁烯基、3-氯_4,4,4-三氟 氟_1_甲基_1_丙烯基、3,3,3-三氟 氟甲基-1，烯基、-三氟|三 基、4,4,5,5,6,66 鼠I戊稀基、4,5,5-三氟-4-戊烯 在各個扑定夕2亂己烯基及2_全氟己基乙烯基等’ θ 妷原子數之範圍内選擇。 在本說明查φ + ^ 雙鍵且碳原子i為“環烯基表示具有1個或2個以上 成3員環至6丄…個之環狀不飽和烴基，其可以形 、 早％或複環構造。又，各個環在指定 Γ:=之範圍内可被烧基任意取代，再者，雙鍵可為 門句或外向之任_形斗、 V式。/、之具脰例可列舉如環戊烯-1 一 二、戊烯小基、3_環戊烯小基、環己烯小基、環己 稀'^基、環己稀基、2·甲基-2-環己稀+基、3_甲基_ 2’己烯小基基及雙環[2·2·⑽庚稀|基等，在各個：定 之碳原子數範圍内選擇。 卜在本況明書中之Ca_b鹵代環烯基表示與碳原子鍵結之 氫原子被鹵素原子任意取代之具有丨個或2個以上雙鍵且 314918 77 407073 碳原子數為a _ ^ 们之環狀不飽和烴基，苴可以形成1昌 锿至6員環之單環 ，、了以形成3貝 子數之範圍内可被二。又，各個環在指定之碳原 外向之任—开”。 思取代，再者，雙鍵可為内向或 亦可在側鏈部分，或者叮“ 代了在私構造部分， 原子取代之情、在此二部分；在被2個以上齒素 且-合m a月/ ^寺齒素原子可彼此相同或相異。苴之 具肢例例如為2-氯雙環[⑴卜庚稀 二^ 之碳原子數之範圍内選擇。 寺在口個‘疋 在本說明書中之C炔基 以上參鍵之碳原子赵或 刀子内具有1個或2個 和烴美，1 1 ’”、a至b個之直鏈狀或分枝鏈狀不飽 =其…例可列舉如乙块基、“丙块基、I丙炔 ” Λ Sr基、2_ 丁块基、3_ 丁块基、2·戊快基、 美、Γ^Γ -甲基_3_丁块基、二甲基_2-丙快 2-戊块基、丁块I基2·己块基、卜甲基 Μ 壬炔基、2-癸块基及2-十一炔美 寻，在各個才旨定之碳原子數之範圍内€#。 土 片子^二月書中之Ca-b_块基表示與碳原子鍵結之氫 ==任意取代，且分子内具有1個或2個以上 m 至b個之直鏈狀或分枝鏈狀不飽和烴 =厂被2個以上之由素原子取代之情況’此等齒素 ==相同，亦可相異。其之具體例可列舉如2-氯乙 臭乙块基、2_埃乙块基、3-氯：丙块基、3-漠-2_ 丙块基、…-丙块基、3,3,3_三氣小丙块基、3'氣·&quot; 3M918 78 200407073 基-2·丙炔基、溴-卜甲基-2_丙炔基、弘诚4 〃 T基-2-丙炔 基、3-氯-二甲基_2_丙快基、^臭^山二甲基^丙快基 及3-碘-ΐ，ι_二甲基_2_丙炔基等，在各個指定之碳原子數之 範圍内選擇。 在本說明書中之ca_b烷氧基表示碳原子翁 了 丁数為a至b個 之如上述之烷基基，其之具體例可列舉如 广 1年L暴、乙氧 基、正丙氧基、異丙氧基、正丁氧基、第-^ 矛一丁虱基、異丁 氧基、第三丁氧基、正戊氧基、1-甲基丁氧基、h甲美丁 氧基、3 -甲基丁氧基、1-乙基丙氧基、11_二甲其 τ I丙氧基、 12_二甲基丙氧基、新戊氧基、正己氧基及込丨-二曱美丁 氧基等，在各個指定之碳原子數範圍内選擇。 在本說明書中之Ca_b鹵代烧氧基表示碳原子數為至 b個之如上述定義之鹵代烷基基，其之呈齅 斤 &lt; 丹例可列舉如 二氟曱氧基、三氟甲氧基、氯二氟曱氧基、溴-急 ^ 天一鼠曱氧基、 2 -氟乙氧基、2 -氯乙氧基、2，2,2-三氟乙氧基、1 丄，丄，2，2-四 氟乙氧基、2 -氯-1，1，2 -三氟乙氧基、2 -溴-1 1 2•二&amp; 基、五氟乙氧基、2-&gt;臭-1，1，2,2 -四I乙氧基、22 - &amp; _ ，-一氣 _ 1，1，2- 二氟乙氧基、2,2,2-二氯_1，1_二氟乙氧基、2_氯丙氧美、3 氯丙氧基、七氟丙氧基、2,2,2-三氟-1-三氟曱基乙^美 2,2,3,3-四氟丙乳基、1，1，2,3,3,3-六氟丙氧基及溴1 1 2 3，3,3-六氟丙氧基等，在各個指定之碳原子數範圍内選擇。 在本說明書中之Ca-b烯氧基表示碳原子數兔 j双钓a至b個 之如上述定義之烯基-0-基，其之具體例可列舉， 干乂 2 -丙焊 氧基、2-丁烯氧基、2 -曱基-2-丙烯氧基及3 -曱基^ 314918 79 200407073 基專在各個指定之碳原子數範圍内選擇。 在本說明書中之U代烯氧基表示碳原子數為&amp;至 b個之如上述定義之鹵代烯基基，复 ’’、、 0 /、之具體例可列舉如 鼠-_丙烯氧基、3-氯-2-丙烯氧基、n -其、 ，—鼠_2-丙烯氧 土 3,3-二氯-2-丙烯氧基及2,3,3-三氟_2%降-姑 机A丙烯氧基等，在 σ個指定之碳原子數範圍内選擇。 在本况明書中之C“烧硫基表示碳原子數為&amp;至匕個 之如上述定義之烷基_s_基’其之具體例可列舉如甲硫基、 乙硫基、正丙硫基、異丙硫基、正丁硫基、第二丁:二、 異丁硫基、第三丁硫基、正戊硫基、丨_甲基丁硫基、展=甲 基丁硫基、3_曱基丁硫基、1-乙基丙硫基、二甲基丙石产 ’一甲基丙硫基、新戊硫基及正己硫基辈，产* ^ ”L丞寻，在各個 夺曰疋之碳原子數範圍内選擇。 在本次明書中之Ca_b鹵代烷硫基表示碳原子數為&amp;至 们之如上述疋義之鹵代烷基_s_基，其之具體例可兴 二 Ψ Γτί? J 牛如 一弗L τ瓜基、三鼠甲硫基、溴二氟甲硫基、2 2 2 -知 基、1 1 2 9尸 ，5 —鼠乙硫 ，i，2，h四氟乙硫基、丨，^ —三氟_2_氯_乙硫基、五氟 石瓜基、2-溴四氟乙硫基、七氟丙硫基、 乙 il 1 二 e m ，夂-四 •二鼠甲基乙硫基及九氟丁硫基等，在各個指定之# E 子數範圍内選擇。 反原 在本說明書中之ca_b環烷硫基表示碳原子數為a至匕 上述疋義之環烧基-s -基，其之具體例可列舉如琿 硫基、裱丁硫基、環戊硫基及環己硫基等，在各個护^丙 碳原子數範圍内選擇。 9疋之 314918 80 200407073 在本說明書中之Ca_b烧亞確醯基表示碳原子數為 b個之如上述定義之烷基-S(O)-基，其之具體例可列舉如甲 亞磺醯基、乙亞磺醯基、正丙亞磺醯基、異丙亞碏醉美 正丁亞磺醯基、第二丁亞磺醯基、異丁亞磺醯基及第二 亞石頁si基等，在各個指定之碳原子數範圍内選擇。 在本5兒明書中之Ca-b 代烧亞續酿基表示碳原子數為 a至b個之如上述定義之鹵代烷基-S(〇)-基，复 、昇體例可 列舉如二氟甲亞磺醯基、三氟曱亞磺醯基、 /六一氣甲亞石酱 基、2,2,2-三氟乙亞磺醯基、2-漠-1，1，2,2_四氟乙亞續酿 土丨’2’2，2 -四氟_卜二氟曱基乙亞磺酿基及九氟丁亞石黃鲈 基等，在各個指定之碳原子數範圍内選擇。 m 在本說明書中之Ca_b環烷亞磺醯基表示碳原子數為&amp; 至b個之如上述定義之環烷基_8(〇)_基，其之具體例可、列a 舉如環丙基μ喊、環了基亞俩基、環絲亞料芙 及環己基亞伽基等，在㈣指定之碳原子數範圍内^ 擇0 、 在本說明書中之C“烧石黃醯基表示碳原子數為a =如上述定義之烧基_叫基，其之具體例可列舉如甲錯 二土乙％酿基、正丙石黃醯基、異丙石黃酿基、正丁 =確醯基、異丁續醯基、第三丁確醯基、正戍二 及正己㈣基等，在各個指定之碳原子數範圍内選擇， 在本祝明書中之、函代院磺醯基表示碳原 至b個之如上較義之_代烧基 ，，、、 舉如二氟甲硭疏| _ /、之具體例可列 哭1 土、二氟甲磺醯基、氯二氟甲磺醯基、 314918 81 200407073 二氟曱磺醯基、2,2,2-三氟乙磺醯基、丨 ，丄，zz 口氣乙石黃酿 基及1，1，2-三氣-2-氯乙磺酸基等，在各個指定之碳原 範圍内選擇。 ' 在本&quot;兒月曰中之Ca_b環烧石黃醯基表示碳原子數為a至 b個之如上述定義之環烷基·8〇2_*，其之具體例可列舉如 環丙基磺醯基、環丁基磺醯基、環戊基磺醯基及環己基磺 Sm基專，在各個才曰疋之碳原子數範圍内選擇。
在本說明書中之c“烧胺基表示氯原？之一者被碳原 子數為a至b個之如上述定義之烷基取代之胺基，其之呈 體例可列舉如甲胺基、乙胺基、正丙胺基、異丙胺基、I 丁胺基、異丁胺基及第三丁胺基等，在各個指定之：原子 數範圍内選擇。 在本說明書中之二（Cw烷基）胺基表示二氫原子被可 彼此相同或相異之碳原子數為a至b個之上述烷基取代之 胺基，其之具體可列舉如二甲胺基、乙基（甲基）胺基、二 乙胺基、正丙基（曱基）胺基、異丙基（甲基）胺基、二（正丙 基）月女基、正丁基（曱基）胺基、異丁基（曱基）胺基及第三丁 基（甲基）胺基等，在各個指定之碳原子數範圍内選擇。 在本說明書中之ca_b烷羰基表示碳原子數為a至b個 之如上述定義之烷基-c(0)-，其之具體例可列舉如 (〇)-基、ch3ch2c(o)-基、ch3ch2ch2c(o&gt;基、（ch3)2CHC (〇)-基、ch3(ch2)3c(o卜基、（CH3)2CHCH2C(〇)-基、CH3CH2 ch(ch3)c(o)-基、（ch3)3cc(o)-基、CH3(CH2)4C(0)-基及 CH3(CH2)5C(0)-基等’在各個指定之碳原子數範圍内選 82 314918 200407073 擇。 在本說明書中之Ca_b鹵代烷羰基表示碳原子數為a至 b個之如上述定義之鹵代烷基-C(O)-基，其之具體例可列 舉如 fch2c(o)-基、C1CH2C(0)-基、f2chc(o)-基、C12CH2 C(O)-基、CF3C(0)-基、C1CF2C(0)-基、BrCF2C(0)-基、 cci3c(o)-基、cf3cf2c(o)-基、C1CH2CH2CH2C(0)-基、 CF3CF2CF2C(0)-基及 C1CH2C(CH3)2C(0)-基等，在各個指 定之碳原子數範圍内選擇。 在本說明書中之Ca_b環烷羰基表示碳原子數為a至b 個之如上述定義之環烷基-c(o)-基，其之具體例可列舉如 環丙基-C(O)-基、1-甲基環丙基-C(O)-基、2-甲基環丙基-C(O)-基、2,2-二曱基環丙基-C(O)-基、2,2,3,3-四甲基環丙 基-C(O)-基、環丁基-C(O)-基、環丁基-C(O)-基、環戊基-c(o)-基及環己基-C(O)-基等，在各個指定之碳原子數範圍 内選擇。 在本說明書中之Ca.b烷氧羰基表示碳原子數為a至b 個之如上述定義之烷基-O-C(O)-基，其之具體例可列舉如 ch3oc(o)-基、ch3ch2oc(o)-基、ch3ch2ch2oc(o)-基、 (ch3)2choc(o)-基、ch3(ch2)3oc(o)-基、（ch3)2chch2 oc(o)-基及（ch3)3coc(o)-基等，在各個指定之碳原子數 範圍内選擇。 在本說明書中之Ca_b鹵代烷氧羰基表示碳原子數為a 至b個之如上述定義之鹵代烷基-O-C(O)-基，其之具體例 可列舉如C1CH2CH20C(0)-基及CF3CH20C(0)-基等，在各 83 314918 200407073 個指定之碳原子數範圍内選擇。 在本說明書中之Ca-b烷硫羰基表示碳原子數為a至b 個之如上述定義之烷基-S-C(O)-基，其之具體例可列舉如 ch3sc(o)-基、ch3ch2sc(o)-基、ch3ch2ch2sc(o)-基、 (ch3)2chsc(o)-基、ch3(ch2)3sc(o)-基、（ch3)2chch2 sc(o)-基及（ch3)3csc(o)-基等，在各個指定之碳原子數範 圍内選擇。 在本說明書中之ca-b烷胺羰基表示氫原子之一者被碳 原子數為a至b個之如上述定義之烷基取代之胺甲醯基， 其之具體例可列舉如ch3nhc(o)-基、ch3ch2nhc(o)-基、ch3ch2ch2nhc(o)-基、（ch3)2chnhc(o)-基、ch3 (ch2)3nhc(o)-基、（ch3)2chch2nhc(o)-基、ch3ch2ch (ch3)nhc(o)-基及（ch3)3cnhc(o)-基等，在各個指定之碳 原子數範圍内選擇。 在本說明書中之ca_b環烷胺羰基表示氫原子之一者被 碳原子數為a至b個之如上述定義之環烧基取代之胺甲酸 基，其之具體例可列舉如環丙基-NHC(O)-基、環丁基-NHC(O)-基、環戊基-NHC(O)-基及環己基-NHC(O)-基等， 在各個指定之碳原子數範圍内選擇。 在本說明書中之二（ca.b烷基）胺羰基表示二氫原子被 可彼此相同或相異之碳原子數為a至b個之上述烷基取代 之胺曱醯基，其之具體例可列舉如（CH3)2NC(0)-基、CH3 ch2n(ch3)c(o)-基、（ch3ch2)2nc(o&gt;基、（ch3ch2ch2)2 nc(o&gt;-基及（ch3ch2ch2ch2)2nc(o)-基等，在各個指定之 84 314918 200407073 碳原子數範圍内選擇。
在本說明書中之ca_b烷胺硫羰基表示氫原子之一者被 碳原子數為a至b個之如上述定義之烷基取代之硫代胺甲 醯基，其之具體例可列舉如CH3NHC(S)-基、CH3CH2NHC (s)-基、ch3ch2ch2nhc(s)-基、（ch3)2chnhc(s)-基、ch3 (ch2)3nhc(s)-基、（ch3)2chch2nhc(s)-基、ch3ch2ch (ch3)nhc(s)-基及（ch3)3cnhc(s)-基等，在各個指定之碳 原子數範圍内選擇。 在本說明書中之二（ca_b烷基）胺硫羰基表示二氫原子 可被彼此相同或相異之礙原子數為a至b個之上述烷基取 代之硫代胺甲醯基，其之具體例可列舉如（ch3)2nc(s)- 基、ch3ch2n(ch3)c(s)-基、（ch3ch2)2nc(s)-基、（ch3 ch2ch2)2nc(s)-基及（ch3ch2ch2ch2)2nc(s)-基等，在各 個指定之碳原子數範圍内選擇。 在本說明書中之caeb烷胺磺醯基表示氫原子之一者被 碳原子數為a至b個之如上述定義之烷基取代之胺磺醯 基，其之具體例可列舉如ch3nhso2-基、ch3ch2nhso2-基、ch3ch2ch2nhso2-基、（ch3)2chnhso2-基、ch3(ch2)3 nh so2-基、（ch3)2chch2nhso2-基、ch3ch2ch(ch3) nhso2-基及（ch3)3cnhso2-基等，在各個指定之碳原子數 範圍内選擇。 在本說明書中之二（ca_b烷基）胺磺醯基表示二氫原子 可被彼此相同或相異之碳原子數為a至b個之上述烷基取 代之胺磺醯基，其之具體例可列舉如（ch3)2nso2-基、ch3 85 314918 200407073 CH2N(CH3)so2^ ^ (ch3ch2)2nso2-&amp; . (CH3CH2CH2)2 NSCV基及（CHsCHA^CHANSO2-基等，在各個指定之碳 原子數範圍内選擇。 在本說明書中之二（ca b烷基）磷醯基表示二氫原子可 被彼此相同或相異之碳原子數為u b個之上述烧基取代 之磷醯基，其之具體例可列舉如（CH3〇)2p(〇)_基及（CH3 CH2〇)2P(〇)-基等，在各個指定之碳原子數範圍内選擇。 在本說明書中之二（Ca_b烷基）硫代磷醯基表示二氫原 子可被彼此相同或相異之碳原子數為3至b個之上述烷基 取代之硫代磷醯基，其之具體例可列舉如（CH30)2P(S)_基 及（CHsCH2〇)2P(S)-基等，在各個指定之碳原子數範圍内選 擇。 在本u兒明曰中之二（Ca_b烧基）石夕烧基表示可被彼此相 同或相異之碳原子數為a至b個之上述烷基取代之矽烷 基，其之具體例可列舉如三甲矽烷基、三乙矽烷基、三（正 丙基）石夕烧基、乙基一甲基石夕烧基、正丙基二甲基石夕烧基、 正丁基二甲基矽烷基、異丁基二甲基矽烷基及第三丁基二 曱基矽烷基等，在各個指定之碳原子數範圍内選擇。 在本說明書中之Ca_b烧羰氧基表示碳原子數為a至b 個之如上述定義之烧基·〇(〇)-〇-基，其之具體例可列舉如 CH3C(0)-0·基、ch3ch2c(o)-o-基、ch3ch2ch2c(o)-〇_ 基、（CH3)2CHC(0)-0-基、CH3(CH2)3C(0)-〇一基、（ch3)2 chch2c(0)-0-基、ch3ch2ch(ch3)c(0)-0-基及（ch3)3 CC(ο)-Ο-基等，在各個指定之碳原子數範圍内選擇。 314918 86 200407073 在本說明書中之ca_b鹵代烧羰氧基表示碳原子數為&amp; 至b個之如上述定義之鹵代烷基-c(0)-0-基，其之具體例 可列舉如 FCH2C(0)-〇-基、ClCH2C(0)-0-基、F2CHC(〇广 〇-基、ci2chc(o)-〇-基、cf3c(o)-o-基、cicf2c(0卜〇·基、
BrCF2C(〇h〇-基、CCl3C(0)-0-基、CF3CF2C(0)-CK基、 CF3CF2CF2C(〇)-〇-基及 C1CH2CH2CH2C(〇)_〇-* 等在夂 個指定之碳原子數範圍内選擇。 在本說明書中之ca_b烷磺醯氧基表示碳原子數為a至 b個之如上述定義之烷基4〇2_〇_基，其之具體例可列舉如 3 〇2 〇 基、CH3CH2S02-0-基、CH3CH2CH2S02-〇-基、 (ch3)2chso2-0-基、CH3(CH2)3S(V〇-基、（CH3)2CHc% S〇2 Ο-基、CH3CH2CH(CH3)S02-0_ 基及（CH3)3CS02-CK 基 等’在各個指定之碳原子數範圍内選擇。 在本說明書中之ca b鹵代烷磺醯氧基表示碳原子數為 a至b個之如上述定義之鹵代烷基_s〇2_〇_基，其之具體例 可列舉如CFSSCVCU基及CF3CF2S〇2_〇_基等，在各個指定 之碳原子數範圍内選擇。 在本說明書中之Cab環烧基（Cde)烧基、代環埃 基（Cd_e)烷基、Ca b烷氧基（Cd J烷基、Ca b鹵代烷氧基 e)烷基Ca-b烷硫基（Cde)烷基、鹵代烷硫基（c“）烷基、 口、（ ）pl取代之笨硫基（C“）烷基、ca-b烷亞磺醯基（c“) 烷基、鹵代烧亞石黃酿基（c“）烧基、u石黃驢基 烷基、C“鹵代烧確gf基（Cd e)院基、c“烧魏基（c“）烧基/ C“鹵代烷羰基(Cde)烷基、c“烷氧羰基(c“)烷基 a - b 314918 87 200407073 鹵代烷氧羰基（cd_e)烷基、（:“烷胺羰基（c“）烷基、二（Ca· b烷基）胺羰基（CH)烷基、三（Ca.b烷基）矽烷基（Cd.e)烷基、 可被（Z〗）pl取代之苯基（Cd e)烷基、L-(Cd e)烷基或M_(Cd J 烧基等’表示與碳原子鍵結之氫原子分別被如上述定義之 任意Ca_b環烷基、Ca b鹵代環烷基、b烷氧基、ca b鹵代 烷氧基、Ca.b烷硫基、ca b鹵代烷硫基、可被（zl)pi取代之 苯石爪基、Caeb烷亞磺醯基、ca b鹵代烷亞磺醯基、ca b烷磺 鹼基、ca-b鹵代烷磺醯基、ca b烷羰基、ca b鹵代烷羰基、 ca-b烷氧羰基、ca b ή代烷氧羰基、Ca b烷胺羰基、二（Ca_ b烧基）胺％基、二（Cab烧基）矽烷基、可被（zl)pi取代之苯 基L·基或Μ基取代之碳原子數為dse個之直鏈狀或分 枝狀烴基，在各個指定之碳原子數範圍内選擇。 在本說明書中被R7任意取代之（Ca-b)烷基、被Ris任意 2代之（Ca_b)烷基、被R23任意取代之（Ca b)烷基、被r27任 思取代之（Ca_b)烷基或被R35任意取代之（Cw)烷基表示與 石反原子鍵結之氫原子被任意之R7、R】8、R23、R27或R35任 意取代之碳原子數為u b個之錢狀或分枝鏈狀之煙 基，在各個指定之碳原子數範圍内選擇。此時，各個（c“） 烧基上之取代基R7、Ru、R23、r27或R35存在2個以上時， 各個R、R 、R23、R27或r35可彼此相$或相異。 在本Λ明書中之U代烧氧基（c“）i代;^基，表示 與碳原子鍵結之氫原子^素原子被如上述定義之任意
Ca-b鹵代烷氧基取代之碳原子數為4至e個之如上述定義 之齒代烧基，其之呈辦办丨7 x丨ώ /、例可列舉如2,2,2-三氟-1-(2,2,2-三 3】49]8 88 200407073 氟乙氧基）+(三a甲基）乙基及mi，2_二氯-丨，2,2_三氟乙 虱基）-1，1，2,2,3,3-六氟丙基等，在各個指定之碳原子數範 圍内選擇。 /本說明書中可被R23任意取代之I)齒代烧基表示 與碳原子鍵結之氫原子或鹵素原子被任意之R 2 3取代之碳 原子數為汪至b個之直鏈狀或分枝鍵狀之煙基，在各個指 定之碳原子數範圍内選擇。此時，各個I)烷基上之取代 基R23存在2個以上時，各個R23可彼此相同或相異。 在本說明書中之經甲基（Cde)環烧基、U氧甲基 (cd-e)環院基、ca_b烧硫f基（Cd e)環烷基、c“燒亞磺醯甲 ϋ)環院基、C“烧續酿甲基（Cd e)環烧基、c“稀基“ :二土、c“鹵代烯基(c“)環烷基、C“烷硫基(Cd e)環烷 二从“院亞❹基U環燒基或烧伽基U環院 :寺，表示與碳原子鍵結之氫原子分別被如上述定義之任 思羥基、ca.b烷氧基、c m A . “烯基、Ca_b _代烯基、Ca b烷硫 二“烧亞〜^基或c“燒石黃驢基任意取代之碳原子數 马dSe個之如上述定義 2-乙烯美m 4之5衣烷基，其之具體例可列舉如 丙基、3,3-二甲基-吵甲基]-丙婦基）環丙 I蠢」（2,2:二氯乙稀基）·3,3-二甲基環丙基、2_(2-氯_3,3,3-!(甲丙烯基)-J，3-二甲基環丙基、(甲硫甲基)環丙基、 醯甲基)環丙基(削醯甲基)環丙基、“(甲 氧f美/ 丁基、2·婦丙基環戍基、1-(經甲基）環戊基、1-(甲 乳甲基）環戊基、甲炉w (甲 環戊基、甲其’： _(甲亞磺酿甲基） 基）環戊基、2_(f氧基）環戊基”·（甲 314918 89 200407073 在各個指定之碳原子 硫基）環戊基及2 -(甲硫基）環己基等 數範圍内選擇。 在本說明書中被U任意取代之（Cab)環燒基、被^任 意取代之U環烧基、被R23任意取代之環烧基、被 R任意取代之(Ca.b)環烧基或被R35任意取代之％。環燒 基寻表不與奴原子鍵結之氫原子被任意之r7、、KM、 R27或R35任意取代之碳原子數為&amp;至b個之如上述定義之 環烧基。此時，R7、Rl8、R23、R27或R35之取代可在環構 造部气，亦可在側鏈部分’或者在此二部分，再者，各個 (Ca.b)環烷基上之取代基R7、Rl8、r23、R27或R35存在2 個以上時’各個仏^^^或…可彼此相同或相 異0 在本說明書中可被R23任意取代之I纖環烧基， 表不與碳原子鍵結之氫原子㈣素原子被任意之^取代 之厌原子數為a至b個之如上述定義之環烷基，此時r” ^取代可在壤構造部分，亦可在側鏈部分，或者在此二部 刀，再者，各個（Ca b)環烷基上之取代基KM存在2個以上 時，各個R23可彼此相同或相異。 、j本°兄明書中ca-b烷胺羰基（Cd e)烯基或可被（zl)pi取 代之苯i(C“）烯基等，表示與碳原子鍵結之氫原子分別被 坻疋義之任思Ca-b烷胺羰基或可被（Zi)pl取代之苯基 任意取代之碳房+ * ，、子數為d至e個之如上述定義之烯基，在 各個指定之碳原子數範圍内選擇。 在本°兄明書中被R7任意取代之(C“)烯基、被R18任意 314918 90 200407073 取代之（Ca_b)稀基、被R27任意取代之（Ca b)烯基或被R35任 意取代之（ca_b)烯基，表示與碳原子鍵結之氫原子被任意之 R7、R 、R或R。5任意取代之破原子數為a至b個之如 上述定義之稀基，在各個指定之碳原子數範圍内選擇。此 時，各個（ca-b)烯基上之取代基r7、Rl8、r27或r35存在2 個以上時，各個R7、RlS、R27或R35可彼此相同或相異。 在本說明書中之可被（zl)pi取代之苯基（c“）炔基、萘 基（Cd_e)炔基或L-(Cd_e)炔基等，表示與碳原子鍵結之氫原 子被任意之可被（Ζι)ρΐ取代之苯基、萘基或L基任意取代 之碳原子數為d至e個之如上述定義之炔基，在各個指定 之碳原子數範圍内選擇。 在本說明書中被R7任意取代之（ca_b)炔基、被Ru任意 取代之（Ca_b)炔基、被R27任意取代之（Ca b)炔基或被R35任 意取代之（ca_b)炔基，表示與碳原子鍵結之氫原子被任意之 R7、Rl8、R27或R35任意取代之碳原子數為a至b個之如 C疋義之炔基，在各個指定之碳原子數範圍内選擇。此 時’各個（Ca_b)炔基上之取代基R7、RU、r27或r35存在2 個以上時，各個R7、RU、反27或R35可彼此相同或相異。 一在本說明書中之可被（z】）p】取代之苯基（Ca b)烷氧基表 不與碳原子鍵結之氫原子被可被（zl)pi取代之苯基任意取 代之如上述定義之（Ca b)烷氧基，（Ca b)烷氧基之具體例可 列舉如-CH2〇-基、-CH(CH3)〇-基、-C(CH3)2〇-基、-CH2 CH20-基、-CH(CH3)CH20·基及-c(CH3)2CH2〇-基等，在各 個指定之碳原子數範圍内選擇。 σ 3]49]8 91 200407073 在本說明書中之可被（z1)^取代之苯基（ca_b)烷羰基表 示與碳原子鍵結之氫原子被可被（ΖΟρ!取代之苯基任意取 代之如上述定義之（ca_b)烷羰基，（ca_b)烷羰基之具體例可 列舉如-ch2c(o)-基、-ch(ch3)c(o)-基、-c(ch3)2c(o)_ 基、-ch2ch2c(o)-基、-ch(ch3)ch2c(o)·基、-c(ch3)2ch2 c(o)-基、-ch2ch(ch3)c(o)-基、-ch2c(ch3)2c(o)-基及-ch2ch2ch2c(o)-基等，在各個指定之碳原子數範圍内選 擇。 在本說明書中之可被（z1)^取代之苯基（ca_b)烷氧羰基 表示與碳原子鍵結之氫原子被可被（z1)^取代之苯基任意 取代之如上述定義之（ca_b)烷氧羰基，（ca.b)烷氧羰基之具 體例可列舉如-CH20-C(0)-基、-CH(CH3)0-C(0)-基、- c(ch3)2o-c(o)-基、-ch2ch2o-c(o)基、-ch(ch3)ch2o-c(o)_基及-c(ch3)2ch2o- c(o)-基等，在各個指定之碳原 子數範圍内選擇。 在本說明書中之可被（z1：^取代之苯基（ca_b)烷胺羰基 表示與碳原子鍵結之氫原子被可被（Ζ1)^取代之苯基任意 取代之如上述定義之（ca_b)烷胺羰基，（ca_b)烷胺羰基之具 體例可列舉如-CH2NH-C(0)-基、-CH(CH3)NH-C(0)-基、- c(ch3)2nhc(o)-基、-ch2ch2nhc(o)-基、-ch(ch3)ch2 NH-C(O)-基及-C(CH3)2CH2NH-C(0)-基等，在各個指定之 碳原子數範圍内選擇。 在本說明書中， 「可藉由R2與R3 —起形成C2_6伸烷基鏈，並與鍵結 92 314918 200407073 之氮原子共同形成3至7員環，此時之伸烷基鏈亦可包含 1個氧原子、硫原子或氮原子」， 「可藉由R19與R2〇 一起形成C4 7伸烷基鏈，並與鍵 結之氮原子共同形成5至8員環，此時之伸烷基鏈亦可包 含1個氧原子或硫原子」， 起形成C2_5伸烷基鏈，並與 與 結之氮原子共同形成3纟6員環，此時之伸烷基鏈亦可包 含1個氧原子或硫原子」， ^ 「可藉由R31與R32 一起形成C2-5伸烷基鏈，並與鍵 結之氮原子共同形成3 1 6員環’此時之伸烷基鏈亦可包 S 1個氧原子、硫原子或氮原子」，以及 「可藉由&amp;36與R37 一起形成C2·5伸烷基鏈，並與鍵 結之氮原子共同形成…員環，此時之伸烷基鏈亦可包 2 1個虱原子或硫原子」之具體例可列舉如氮雜環丙烷、 ，雜環丁烧、吼。各烧、帳、噻錢、味錢、脈咬基、 二代嗎，啉、哌哄、高贿及七甲基亞胺基二， 们才曰疋之妷原子數範圍内選擇。 在本說明書中， 「可藉由R9盥Rl〇 一 之原子共同形成3至7員》：C2·6伸燒基鏈’並與鍵結 個氧原子、硫原子或氮；；’：時之伸燒基鍵亦可包幻 燒、氮雜環丁炫、氮===體例可列舉如氮雜環丙 _、嗜唾烧、嗜唾烧相、噻奸^°各炫'^各燒士 味唑烷-2-酮、哌啶、哌…。烷_2’、。米唑烷、 …、嗎福啉、四氫-1，3,井_ 314918 93 200407073 酉同、脈D井、四氫。密口定 在各個指定之碳原子 顯I、硫代嗎福啉、四氫q，3_噻哄-2 - 21同、高碳哌啶及高碳哌啶_2_酮等， 數範圍内選擇。
「可藉由R9與R&quot; 一起形成C 2·4評沉基鏈，亚與鍵結 :!子共同形成…員環’此時之伸院基鏈亦可包含i 乳原一子:硫原子或氮原子」之具體例可列舉如異噚唑啉、 ，’2-一卩亏唑啉、M，2_噚噻唑啉、丨，^卩萼二唑啉、二 1，2 « 口萼哄、二氫_ J 4 2 _ - 口骂井-气里 4H]52,4-口萼二畊及四氫q 2-口等 ^ 子數範圍内選擇。 …寺’在各個指定之碳原 :::明所包含之化合物中，以G表示之雜環 “之对圍’例如為g-H+g-sk'g G-Π、G]2、G-13、G-14、G」5、r 17 广 、 Γ ^ l5、G_17、G-18m22、 G-23 、 G-32 、 G-33 、 G-4G 、 G 41 、 Γ r ^ G_41、GA、G-53、G_54、 G-55、G-56及G-71組成之群。 在本發明所包含之化合物中，以_或w 基，例如氧眉子或石*原早 一 又不之取代 乳原子或石&quot;原子，其中以氧原子為較佳。 在本發明所包含之化合物中，以 圍例如包含下述各群： |代基之範 n :鹵素原子； m:氰基及硝基； mi ·虱原子、Ci_6烷基及c】6鹵代烷基； X_IV · Cl·6烷氧基及C】‘6鹵代烷氧基； nc]_6烧硫基、c】4代烧硫基、完亞仙基、 3]4918 94 200407073 c】_6鹵代燒亞石黃醯基、c】_6烧石黃酸基及cv6鹵代垸石黃醯基； X-VI ·· -N(R17)R16[其中，R16表示氫原子、Cl6烧基、 元氧基（Cw)烧基、C1-4烧硫基（Cw)烧基、-CH〇、C! 6丈元Ik基、C1-0鹵代烧罗厌基、Cs·6環烧幾基、ci-6烧氧幾基、 Cu鹵代烧乳.基或Cu烧硫幾基，以及R17表示氫原子 或C&quot;烷基，或者R17與R2亦可一起形成_CH2_]。 在本發明所包含之化合物中，以γ表示之取代基之範 圍例如包含下述各群： Y-1 :氫原子； Y-II :鹵素原子； Y -111 ·· C1 _ 6 烧基； Y-IV:C卜6鹵代烷基、羥基（Cl_6)烷基及Ci4烷氧基（C14) 烷基； Y-v : c卜6烷氧基； Y-VI ·· Cw烷硫基。 在本發明所包含之化合物中，以R1表示之取代基以氫 原子為較佳。 ’ 在本發明所包含之化合物中，以R2表示之取代基之範 圍例如包含下述各群： R2-I :氫原子； R2-n : C卜6烷基； R2-III : c】_4烷氧基（Ci4)烷基及Ci4烷硫基（Cw)烷 基； RMv : C3_6烯基及c3 6炔基。 314918 95 200407073 在本發明所包含之化合物中，以R3表示之取代基之範 圍例如包含下述各群： R3-i : Cw烷基及c3_8環烷基； R3-ii : c3_8烯基及c3_8炔基； R3-III : R280-(Cl_8)烷基[其中，r28 表示 Cl_6 烷基或- C(0)N(R32)R31，其中r3】表示Ci 6烷基及R32表示氫原子 或c烧基]; R3-IV : Rno^Cu)烷基[其中，R2 8表示氫原子、c 1-6 烧基、Cu鹵代烷基、C】_4烷氧基（Cl-4)烷基、Cw烷硫基 (C1·4)烷基、可被（Z1)”取代之苯基（CY4)烷基、Cu烷羰基、 C3-6環烷羰基、-c(o)n(r32)r31、二（c】_6烷基）磷醯基、二 (ci-6烷基）硫代磷醯基、三（C1-4烷基）矽烷基或可被（z1)^ 取代之苯基，R31表示CV6烷基、Cw烷硫基（cv4)烷基、 可被（z1)”取代之苯基（CV4)烷基、cs·6環烷基、C：3·6烯基或 可被（Z1)!^取代之苯基，R32表示氫原子或C!·6烷基，或者 亦可藉由R31與R32 —起形成C2·5伸烷基鏈並與鍵結之氮 原子共同形成3至6員環，此時之伸烷基鏈亦可含有1個 氣原子或硫原子]、（M-l)-(C〗-8)烧基、（M_2)-(Ch)烧基、 (MJHCu)烷基、烧基、（Μ_5)-(ζν8)烷基、 (16)-((^8)烷基、烷基、烷基、 (M-15)-((^.8)烷基、（M-16)-(CV8)烷基、烷基、 (^1-24)-((^.8)烧基、8)烧基、M-4、M-5 ' M-14、 M-15 及 M-16 ; R3-V表示CV8鹵代烷基、C3_6環烷基（C】_8)烷基、三（c 96 3149]8 200407073 烷基）矽烷基（C^8)烷基、可被（ζι)ρι取代之苯基烷 基、（L-1)-(CV8)烧基、（L-2)-(CV8)烷基、（L-3HCH)烷基、 (L-4)-(CV8)烧基、（145)-((^8)烷基、（L-46)-(C1-8)烷基、 (L-47)-(C】_8)烷基、C3-8烯基、可被（Zypi取代之笨基（c36) 烯基、CM炔基、可被（ζι)ρι取代之苯基（C3 6)炔基、萘-^ 基 _(C3_6)炔基、萘-2-基-((：3·6)炔基、（L-1)-(C3_6)炔基、（L-2)-(C3_6)炔基、（L-3)-(C3_6)炔基、（L-4)-(C3_6)炔基、（L-45) -(C3_6)炔基、（L-46)-(C3_6)炔基及（1^47)-((：3_6)炔基； R3-VI ··氰基（C&quot;)烧基、Cu烧氧幾基（Cu)烧基、Cw 烷胺羰基（CV8)烷基、二（cv6烷基）胺羰基（cv8)烷基、HON= qRWMCu)烷基、ν3〇Νβ(Κ34)-((ν8)烷基[其中 R33 表示 C1-6烧基或可被（Z1)^取代之苯基（Cb4)烧基，R34表示氫原 子或Cw烷基]以及Cb6烷胺羰基（c3.6)烯基； R3-VII : CV4烷硫基（CV4)烷基、Cw烷亞磺醯基（CV4) 烧基及Cw烧石黃酿基（Ci-4)烧基； R3-VIII : ΗΟΝ=€Η_(〇ν8)烷基、烧基 [其中，R33表示Cu烷基]; R3-IX : R28(R29)N- (Cu)烷基[其中 R28 表示 c&quot;烷氧 罗炭基、C1-6烧績酿基或二（C〗.6烧基）硫代ί粦酸基，R29表示 氫原子或c^6烷基]; R3-X : R30S(O)r-(C】_8)烷基[其中，R30 表示 CV6 烷基、 CV6鹵代烷基、羥基（Cw)烷基、C,.4烷氧基（Cb4)烷基、cv4 烷硫基（CV4)烷基、CV4烷羰基（(^.4)烷基、Cm烷氧羰基 (CV4)烷基、二（cv4烷基）胺羰基（U烷基、三（CV4烷基） 97 3Ϊ4918 200407073 矽烷基（CV4)烷基、可被（z1：^取代之苯基（Ci4)烧基、 細基、C3_6快基、C].6烧硫基、可被（Ζ!)Ρ1取代之苯基、l_2i 或 L-45，r 表示 0 至 2 之整數]、（M-8)-(Ci8)烷基、（Μ-9)-(c】_8)烷基、（]^_1〇)-((：卜8)烷基、（m_ii)-(Ci_8)烷基、（Μ-17) -(Cu)燒基、（M-18)· (CV8)烧基、（Μ-19)- (ci8)烧基、（Μ-26) -(C 】· 8)燒基、（Μ - 2 7) _ (C 】_ 8)院基、（Μ _ 2 8) - (c! 8)烧基、μ - 8、 Μ_9、Μ-17、Μ-18 及 Μ-19 ; R3-XI : r28(r29)n- (Cu)烷基[其中R28表示c〗_6烷羰 基、CS·6環烷羰基、C!·6烧氧羰基、二（ci-6烷基）胺羰基、 Cu烧續酿基、二（C!·6烧基）胺續酿基、可被（z1)”取代之 苯磺醯基或二（C^烷基）硫代磷醯基，R29表示氫原子或 Cu 烧基]、（M-12)-((^.8)烷基、（M-13)- (U烷基、（M-20) -(Cu)烷基、（M-2 1)-((^.8)烷基、（1^-22)-((^4)烷基、M-13、 M-21 及 一22 ; R3-XII : R2與R3 —起形成之3至7員環，如氮雜環丙 烧、氮雜環丁烷、吡咯烷、噚唑烷、噻唑烷、哌啶、嗎福 啉、硫代嗎福啉及高碳哌啶； R χΠΐ: C〗_8烷基、c3_8環烷基、c3.8烯基及c3.8炔基； R3'XIV : C〗_6烷基、cv4烷硫基（Ci 4)烷基、c】_4烷亞 石頁&amp;基（clM)烷基及c】4烷磺醯基（u烷基； R _XV : R28〇兴C】_8)烷基[其中，r28表示c】_6烷基或_ =(0)N(R )R3】，其中RS1表示烷基及R32表示氫原子 或Cl·6烷基]、C,·4烷硫基（ci-4)烷基、CV4烷亞磺醯基（c“ 4)烷基及cK4烷磺醯基（(^_4)烷基； 314918 98 200407073 R3-XVI : CV6烧基、r28〇_(c】-8)烧基[其中，R28表示
Cl_6烷基或-C(〇)N(R32)R3l，其中R”表示Ci6烷基及R32 表示氫原子或Cw烷基]、Ci 4烷硫基（Ci 4)烷基、 L 1.4况亞 磺醯基（Cw)烷基、Cy烷磺醯基（Cw)烷基、R28(r29)n_ (Cw)烷基[其中R28表示c]_6烷氧羰基、Ci_6烷磺醯基或二 (Cw烷基）硫代磷醯基，R29表示氫原子或Cw烷基]、 HON-CH-CC&quot;)：^ 基及 r3 3〇n=ch_(c&quot;)烧基[其巾，r33 表 示Cw烷基]。 、 在本發明所包含之化合物中，以R4表示之取代基之範 圍例如包含下列各群： R4·1 : Cw烷基及ci 6鹵代烷基； R 11 . c3-6環燒基（c14)烧基、c3_6鹵代環烧基（c卜4) 烷基、CV4烷氧基（Ci 4)烷基、Ci 4鹵代烷氧基（U烷基、 Cle4烧硫基（C1-4)烷基、cN4鹵代烷硫基（CV4)烷基、CV4烷 亞確酸基（(^_4)烷基、c] 4鹵代烷亞磺醯基（Ci 4)烷基、 烧石只基（c】·4)燒基、c1-4鹵代烧石黃醯基（cv4)烧基、氰基 (C]·6)：!：完基及C1-4鹵代烷氧基（(^4)鹵代烷基； R ·ΙΙΙ · C3_8環烧基、C3_8鹵代環烧基、M-4、M-5、 M-8、M-9、M-14 至 M-18 及 M-19 ; R4-IV :可被（ζι)ρι取代之苯基、丨_萘基及2_萘基； R4-V : L-1 至 L-4 、 L-8 至 L-13 、 L-15 至 L-23 、 L-25 至 L-35、L-37、L-38、L-40、L-43 至 L-57 及-58 ; R4H··氫原子、C】.6烷基及Cm鹵代烷基； R -VII ·氫原子、鹵素原子、（^_6 ：)：完基及C^6鹵代烧 99 314918 200407073 基； r4-viii : c“烷氧基、Cl 6 _代烷氧基、Cl_6烷硫基、 &lt;^_6鹵代烷硫基、cle6烷亞磺醯基、Cl.6鹵代烷亞磺醯基、 c^·6烷磺醯基及c1-6鹵代烷磺醯基； R-IX·鹵素原子及代烧基。 在本發明所包含之化合物中，以R5表示之取代基之範 圍例如包含下列各群： R5]:氫原子 '鹵素原子、氰基、CY6烷基、Cu鹵代 烧基、Cw烷氧基、Cl_6鹵代烷氧基、可被（Ζι)ρι取代之苯 氧基、Cl-6烧硫基、Ch6鹵代烧硫基、可被（z1；^取代之苯 硫基、Cw烷亞磺醯基、Cl_6鹵代烷亞磺醯基、可被（Z1)^ 取代之苯亞磺醯基、C16烷磺醯基及Cw鹵代烷磺醯基、 可被（Z1：^取代之苯磺醯基、Ci6烷胺基及二（Cw烷基）胺 基； RMl : C3_6環烷基（Cm)烷基、C3_6齒代環烷基（cv4) 烧基、Ch垸氧基（Ci 4)烧基、c14 _代烧氧基（c] 4)烷基、 &lt;^_4烧硫基（c1-4)烷基、Ci 4鹵代烷硫基（Ci 4)烷基、Cl_4烷 亞石黃酸基（CK4)烷基、C]4鹵代烷亞磺醯基（Ci4)烷基、 烧確酿基（c】-4)烷基、Ci 4鹵代烷磺醯基（Ci 4)烷基及氰基 (cv6)烷基； R5-ni : C3.8環烷基、C3_8鹵代環烷基、吼咯烷-1-基、 曙唾烧-3-基、噻唑烷_3_基、哌啶-^基、嗎福啉-丨·基及M; R5-!V ： -CHO ^ -C(0)R9 ^ -C(0)0R9 &gt; -C(0)SR9 &gt; -C(0)NHR10^ -C(O)N(R10)R9&gt; -C(S)NHR10^ -C(S)N(R]°)R9 ^ 100 314918 200407073 -CH=NORU 及-C(r9)=NOR&quot;[其中，r9 表示 c“烷基、c“ 鹵代烷基、可被（Ζ1)^取代之苯基（Ci·4)烷基、C3 8環烷基6 或可被（Ζ〇Ρ1取代之苯基，其中Rl〇表示氫原子或c^烷 基；或者亦可藉由R9與—起形成CrC5伸烷基鏈，並 與鍵結之氮原子共同形成5員環或6員環，此時之伸烧基 鏈亦可含有1個氧原子或硫原子，rii表示Ci6燒基、^ 鹵代烷基、或可被（z1)^取代之苯基（Cl·4)烷基，或者可藉 由R與R —起形成CfC3伸燒基鏈，並與鍵結之原子共 同形成5員環或6員環，此時之伸烷基鏈可被烷基任 意取代]; R V· 了被（ζ )ρι取代之本基、ι_蔡基、2_蔡基及l; r5-vi · i素原子、Ci 6烷基、c&quot;鹵代烷基、C3_6環 烷基、Cw _代烷氧基、Cl_6烷硫基、Ci 6烷亞磺醯基、c 1-6 烷磺醯基或二（C1-6)烷胺基； R5-VII :可被（Ζι)ρι取代之苯基、至L-5、L-8至 L-24 、 L-28 至 L_36 、 l，39 、 L_41 、 L-42 、 L-45 至 L-47 或 L-50 ； R5-VIII ·氫原子、鹵素原子、C16烷基及ci 6鹵代烷 基； R5-IX :氛基、c36環烷基（c】_4)烷基、c36鹵代環烷基 (C1-4)烧基、Cb4烷氧基（Ci 4)烷基、Cl 4鹵代烷氧基（Ci 4) 烧基、CV4烧硫基（c]_4)烷基、Ci-4鹵代烷硫基（Ci 4)烷基、 Cy烧亞續酿基（u烷基、Cl.4鹵代烷亞磺醯基（u烷 基、c】-4烧石黃酸基（cK4)烷基、cv4鹵代烷磺醯基（Cm)烷基 101 314918 200407073 及氰基（Cl-6)烷基； R x . c3_8環烷基、c3 8鹵代環烷基及M ; R5-XI ^ p 斤备甘 I-6烷乳基、CK0鹵代烷氧基、可被（zl)取 代之本氧基、C ^ h-6烷4基、C〗_6鹵代烷硫基、可被（zl 取 、 1-6烷亞石頁基、cv6鹵代烷亞磺醯基、可 被（冗1)?1取代之絮π ^ 长 、 本亞、&amp;基、C】_6烷磺醯基、c〗_6 _代烷磺 I基可被（Z1)P1取代之笨磺醯基及Si(R13)(Rl4)Rl2 ; R -XII .可被（ζ1)ρι取代之苯基、卜萘基或2_萘基； R -XIII · L-1 至 L-4、L-15 SL-17、L-19、L-20、L- 22 、 L-23 、 L-45 至 L-47 或 l_5〇 ; ΚΛΧίν :氫原子； R5-XV :氫原子、C1-6烷基及c&quot;鹵代烷基。 在本發明所包含之化合物中，以R6表示之取代基之範 圍例如包含下述各群。 R6-I : R63及R6b各自獨立，表示氫原子、鹵素原子、 Ci_6烧基或Cw鹵代烧基； R6-II : R6a及R6b各自獨立，表示氫原子或Ch6烷基， R6e表示氫原子、鹵素原子、氰基或Ci.6烷基； R、III ·· R6a、R6b、R6e及R6d各自獨立，表示氫原子、 鹵素原子、C ! _ 6烧基或C i _ 6鹵代烧基； RMV : R6a及R6b各自獨立，表示氫原子、鹵素原子、 Cb6烷基或C】_6鹵代烷基，R6c表示氫原子； R6-V ·· R6a及R6b各自獨立，表示氫原子、鹵素原子、 C!-6烷基或C】-6鹵代烷基，R6e及R6d各自獨立，表示氫原 102 314918 200407073 子或Cw烷基； R6-VI ·· R6a及R6b各自獨立， R6e , ^ E 表不虱原子或Cw烷基， 义不氮原子、Cu燒基、Cl6烧石:±而衣| siA . ^ ^ ·6 兀 基、Cl6 鹵代烷磺 〜基及可被（Ζι)ρ1取代之苯磺醯基、 A 1 &gt; 1 Cl_6烷碳基、CV6鹵代 心放基、可被（ζι)ρΐ取代之苯羰基、 代垸氧m基及可被（2%取代之苯㈣基、c“函 酿基或可被（z%取代之苯基；元㈣ R6-VII : Rh及R6e各自獨立 矛不虱原子或cv6烷基； R6-VIII : 及R6b各自獨立， ,0 ^ 表不虱原子、c】_6烷基 或_代烧基； R6-IX: R“、R6b、心及 R6d 夂 0 、 σ自獨立，表示氫原子、
Ci-6烧基或代燒基； R6-X : R6f、R6g 及 R6h 各自 合目獨立，表示氫原子、c 烷基或CV6鹵代烷基； R6_XI:R6i表示氯原子、鹵素原子、氰基、Cl6^、 代烧基U氧幾基或u代燒氧幾基；心及 R6k各自獨立，表示氫原子、鹵专盾尽 团f原子、鼠基、C“烷基或 鹵代烷基； R6-XII:e表示氫原子’ R6j及R6k各自獨立，表示氫 原子、鹵素原子、氰基或Ci烷基。 工 在本發明m包含之此等化合物中，《示各取代義之範 圍之各群可任意地組合，且分別表示本發明化合物1範 圍。關於G、R4、R5及Μ之範圍之組合之例子，例如為下 表1所示之組合，不過第i表所列之組合係為了例示’ 314918 10： 200407073 發明並非僅限於此。 第1表
G R4 R5 R6 G-1 R4-I R5-VII R6 - II G-1 R4 -1 R5-XII R6 - II G-1 R4-IV R5-VI R6 - II G-1 R4-IV R5-VIII R6 - II G-1 R4-IV R5-XIV R6 - II G-1 R4 - V R5-YI RMI G-1 R4-V R5-VIII R6 - II G-1 R4 - VI R5-VII RMI G-1 R4 - VI R5-XII R6 - II G-4 R4-1 R5 - V R6 - ΙΠ G-4 R4 -1 R5-VII R6 - ΙΠ G-4 R4-I R5-XII R6-III G- 4 R4-I R5-XIII R6 - ΙΠ G-4 R4 - II R5-VII R6-III G-4 R4 - II R5-XII R6-III G- 4 R4-III R5-I R6-III G-4 RMII R5 - II R6-III G-4 R4-III R5 - VI R6-III G-4 R4-III R5-VIII R6 - m G-4 R4-IV R5-1 RMII G-4 R4 - IV R5 - VI R6-III G-4 R4-IV R5-VIII R6-III G-4 R4 - V R5-I R6-III G-4 R4 - V R5 - VI R6-III G- 4 R4 - V r5 - vm R6-III G-6 R4 -1 R5-V R6 - IV G- 6 R4-1 RMII R6-IV G-6 R4-I R5-XII R6 - IV G- 6 R4-I R5~XII1 R6 - IV G-6 R4-II R5-VII R6-IV 第1表（接下頁)
G R4 R5 R6 G-41 R4-I R5-VII R6-IX G- 41 R4-I R5-XII R6-IX G~41 R4-IV R5 - VI R6-IX G-41 R4-IV R5-VIII R6 - IX G- 41 R4-IV R5-XIV ’R6-IX G-41 R4 - V R5-VI R6-IX G-41 R4 - V R5-VIII R6-IX G-41 R4 - VI R5-VII R6 - IX G~41 R4-VI R5-XII R6 - IX G-5 R4 -1 R5 - V R6-V G- 5 R4 -1 R5-VII . R6-V G-5 R4-I R5-XII R6 - V G-5 R4 -1 R5-XIII R6-V G-5 R4-II R5~VII R6 - V G-5 R4 - II RMII R6_V G-5 R4-III R5-I R6-V G-5 Mil R5-II R6-V G-5 R4 - m R5-VI R6 - V G- 5 R4-III R5 - vm R6 - V G-5 R4 - IV R5 -1 R6 - V G-5 R4-IV R5-VI R6-V G- 5 R4 - IV Rs-VIII R6 - V G-5 R4 - V R5 -1 R6-V G-5 R4-V R5 - VI R6-V G-5 R4 - V R5-VIII R6 - V G-6 R4-III R5 - VI R6-IV G-6 R4-III R5-VIII R6-IV G^6 R4 - IV R5 -1 R6 - IV G-6 R4_IV R5-VI R6-IV G-6 R4-IV R5-VIII R6-IV 314918 200407073 G-6 R4 - II R5-XII R6-IV G-6 R4-V R5-I R6 - IV G*~6 R4-III R5 -1 R6-IV G-6 R4~V R5 -VI R6-IV G-6 R4-III R5-II R6-IV G-6 R4-V R5-VIII R6-IV G-7 R4-I R5-I R6 -1 G-7 R4 - IV R5_I R6-I G-7 R4-I R5-II R6-I G-7 R4 - IV R5-II R6-I G-7 R4-I R5-III R6-I G-7 R4-IV R5-III R6~I. G-7 R4 -1 R5-IV R6-I G-7 R4-IV R5 - IV R6 -1 G-7 R4-I R5-V R6 -1 G-7 R4 - IV R5 - V R6 -1 G-7 R4 -1 R5 - VI R6-I G-7 R4-IV R5 - VI R6 -1 G-7 R4-I R5-VII R6-I G-7 R4-IV R5-VII R6 -1 G-7 R4 -1 R5-VIII R6-1 G- 7 R4 - IV R5-VIII R6 -1 G-7 R4-I R5 - IX R6 -1 G-7 R4-IV R5 - IX ’R6-I G-7 R4-I R5-X R6 -1 G-7 R4-IV R5 - X R6-I G-7 R4-I R5 - XI R6 -1 G-7 R4-IV R5 - XI R6-I G-7 R4-I R5-XII R6-I G-7 R4-IV R5-XII R6-I G-7 R4-I R5-XIII R6 -1 G-7 R4-1V R5-XIII R6-I G-7 RMI R5 -1 R6_I G-7 R4-V R5-I R6-1 G- 7 R4-II R5 - II R6-I G~7 R4-V R5-II . R6-I G-7 RMI R5-III R6-1 G-7 R4-V R5-III RM G-7 R4-II R5-IV R6_I G-7 R4-V R5 - IV R6-I G-7 R4 - II R5-V R6 -1 G-7 R4-V R5 - V R6-I G-7 R4 - II R5 - VI R6 -1 G- 7 R4 - V R5 - VI R6 -1 G-7 R4-II R5-VII R6-1 G-7 R4 - V R5-VII R6 -1 G-7 R4-II R5-VIII R6 -1 G-7 R4-V R5-VIII R6 -1 G-7 R4-II R5 - IX R6 -1 G-7 R4 - V R5-IX R6-I G-7 R4 - II R5-X R6 -1 G-7 R4-V R5 - X R6-I G-7 R4-II R5-XI R6-I G-7 r-v R5-XI R6 -1 G-7 r-n R5-XII R6_I G-7 R4-V R5-XII R6-I G-7 R4 - II R5-XIII R6 -1 G-7 R4 - V R5-XIII R6 -1 G-7 R4-III Rs -1 R6 -1 G-7 R4 - VI R5 -1 R6 -1 G-7 R4-III R5 - II R6 -1 G-7 RM，I R5 - II R6 -1 G-7 R4 - ΙΠ R5-III R6-I G-7 R4 - VI R5-III R6-I G-7 R4*-III R5 - IV R6-I G-7 R4 - VI R5 - IV R6-I G-7 R4-III R5 - V R6-1 G-7 R4-VI R5-V R6-I G-7 R4~Ili R5-VI R6-I G-7 R4-VI R5_VI R6 -1 G-7 R4-III R5-VII R6 -1 G-7 R4-V1 R5-VII R6 -1 G-7 r4 - m R5-VIII R6 -1 G-7 R4 - VI R5-VIII R6 -1 105 314918 200407073
G-7 R4-III R5-IX R6 -1 G-7 R4-III R5-X R6-I G-7 R4-III R5-XI R6 -1 G-7 R4-III R5-XII R6 -1 G-7 R4-III R5-XIII R6-I G-11 R4-I R5-VII R6 - VI G-11 R4 -1 R5-XII R6-VI G-11 R4-IV R5 -1 R6-VI G-11 R4-IV R5 - VI R6 - VI G-ll R4-IV R5-VIII R6 - VI G-11 R4-IV R5-XIV R6-VI G-ll R4-VI R5 -1 R6 - VI G-ll R4 - VI R5 - V R6 - VI G~ll R4-VI R5 - VI R6 - VI G-ll R4-VI R5-VII R6-VI G -11 R4 -VI R5-VIII R6 - VI G-ll R4-VI R5-XIV R6-VI G-12 R4 -1 R5-I r - vi G -12 R4 -1 R5 - VI R6-VI G-12 R4-I R5-VII R6 - VI G-12 R4 -1 R5-VIII R6 - VI G-12 R4 -1 R5-X R6 - VI G -12 R4 -1 R5-XII R6 - VI G-12 R4-I R5-XIV R6-VI G-12 R4 - IV RM R6 - VI G -12 R4 - IV R5 - VI R6 - VI G-12 RMV R5-VIII R6-VI G-12 R4-IV R5-XIV R6-VI G-12 R4-VI R5-I R6-VI G-]2 R4 - VI R5 - VI R6-VI G-12 R4-VI R5-VIII R6-VI G-12 R4 - VI R5-XIV R6-VI G-13 R4-I R5-III R6-VI11 G -13 R4-I R5-V R6-VIII G-13 R4-I R5-V1I RM，III G-13 R4-I R5 - X RMqn G-13 R4-I R5-XII R6-VIII G-7 R4 - VI R5-IX R6 -1 G-7 R4-VI R5-X R6 -1 G- 7 R4-VI R5 - XI R6 -1 G-7 R4-VI R5-XII R6 -1 G-7 R4-VI R5~XIII R6 -1 G- 21 R4-I R5-VII R6-VI G-21 R4 -1 R5-XII R6-VI G-21 R4-IV R5-I R6-VI G-21 R4-IV R5-VI R6-VI G-21 R4-IV R5-VIII R6-VI G-21 R4-IV R5-XIV R6 - VI G-21 R4-VI R5 -1 ’R6-VI G-21 R4-VI R5-V R6 - VI G-21 R4 - VI R5 - VI R6 - VI G-21 R4 - VI R5-VII R6-VI G-21 R4-VI R5-VIII R6 - VI G- 21 R4 - VI R5-XIV R6-VI G - 22 R4 -1 R5 -1 . R6-VI G - 22 R4 -1 R5 - VI R6-VI G - 22 R4 -1 R5-VII R6-VI G-22 R4-I R5-VIII R6 - VI G-22 R4 -1 R5 - X R6-VI G - 22 R4-I R5-XII R6-VI G-22 R4 -1 R5-XIV R6-VI G - 22 R4-IV R5_I R6-VI G-22 R4 - IV R5 - VI R6-VI G-22 r-iv R5-VIII R6-VI G-22 R4 - IV R5~XIV R6-VI G-22 R4-VI R5 -1 R6 - VI .G-22 R4-VI R5 - VI R6 - VI G-22 R4 - VI R5-VI11 R6 - VI G-22 R4 - VI R5-XIV R6 - VI G -17 R4-I R5 - ΠΙ R6-VIII G-17 R4 -1 R5 - V R6-VIII G -17 R4 -1 R5-VII R6-VIII G-17 R4 -1 R5-X mil G-17 R4-I RMII R6-VI11
106 314918 200407073
G-13 R4 -1 R5-XIII R6-VIII G-13 R4-II R5-VII r-vni G-13 R4-III R5 -1 R6-VIII G-13 RMII R5 - II R6-VI11 G-13 R4-III R5 - VI R6-VIII G -13 R4-III Mill R6-YIII G-13 R4-III R5-XIV R6-VIII G-13 R4-IV R5-I R6-VIII G-13 R4-IV R5-VI R6-VIII G-13 R4-IV R5-VIII R6-VIII G-13 R4 - IV R5-XI R6-VIII G-13 R4 - IV R5-XIV R6-VIII G-13 R4-V R5 -1 R6-VIII G-13 R4-V R5 - VI R6-VIII G-13 R4 - V R5-VIII R6-VIII G-13 R4_V R5-XI R6-VI11 G -13 R4-V r5-)αν R6-VIII G-14 R4 -1 R5-III R6-VIII G -14 R4 -1 R5-V R6-VIII G-14 R4 -1 R5-VII R6-VIII G-14 RM R5-X R6-VIII G-14 R4 -1 R5-XII R6-VIII G~14 R4-I R5-XIII R6-VIII G-14 R4-II R5-VII R6-VIII G-14 RMII R5 -1 R6-VIII G-14 R4-III R5-II R6-VIII G-14 R4-III R5-VI R6-VIII G-14 R4-III R5-VIII R6-VIII G-14 R4-III R5-XIV R6-VI11 G-14 R4-IV R5-I R6-VIII G-14 R4 - IV R5 - VI R6-VI11 G_14 R4-IV R5-VIII nm G'14 R4 - IV R5-XI R6-VIII G-14 R4 - IV R5-XIV R6-VIII G-14 R4-Y R5 -1 r6 - vm G-14 R4 - V R5-VI R6-VIII G-14 R4 - V R5-VI1I R6-VIII
G-17 R4 -1 R5-XIII R6-VIII G -17 R4 - II R5-VII r6 - vm G-17 R4-III R5-I R6-VIII G-17 R4-III R5 - II R6-Y1II G-17 R4-III R5-VI R6-VIII G-17 R4*III R5-VIII R6-VIII G-17 R4-III R5-XIV R6-VIII G-17 R4-IV R5-I R6-VIII G-17 R4 - IV R5-V1 R6-VIII G-17 R4 - IV R5-VIII R6-VIII G-17 R4-IV R5 - XI R6-VIII G-17 R4-IV R5-XIV R6-VIII G-17 R4-V R5-I R6-VIII G-17 R4-V R5 - VI R6-VIII G -17 R4-V R5-VIII R6-VIII G-17 R4-V R5 - XI R6-VIII G-17 R4 - V R5-XIV R6-VIII G -18 R4 -1 R5-ΠΙ . R6-VIII G-18 R4 -1 R5 - V R6-VIII G-18 R4 -1 R5-VII R6-VIII G-18 R4 -1 R5 - X R6-VIII G-18 R4-I R5-XII R6-VIII G-18 R4-I R5-XIII R6-VIII G-18 R4-II R5-VII R6-VIII G-18 RMII R5 -1 R6-VIII G-18 R4-III R5-II R6-VIII G-18 RMII R5*VI R6-VIII G-18 R4-III R5-VIII R6-VIII G-18 R4-III R5-XIV R6-VIII G -18 R4 - IV R5 -1 R6-VIII G-18 R4-IV R5-VI R6-VIII G-18 R4 - IV RM，III R6-VIII G-18 R4-IV R5-XI R6-VIII G-18 R4-IV R5-XIV R6-VIII G-18 R4-V· R5-I R6-VIII G-18 R4-V R5-VI R6-VIII G~18 R4-Y R5-YIII R6-VIII 107 314918
G-14 R4 - V R5-XI r6 - vm G -14 R4-V R5-XIV R6-VIII G -15 R4 -1 R5 - V R6-VIII G-15 R4-I R5-VII R6-VIII G-15 R4 -1 R5-XII R6-VIII G -15 R4 - i R5-XIII R6-VIII G-15 R4-II R5-VII R6-VIII G -15 R4-III R5 -1 R6-VIII G-15 R4«III R5 - Π R6-VIII G-15 R4-III R5-YI R6-VIII G-15 R4-IV R5-I r6 - vm G-15 R4 - IV R5 - VI R6-VIII G-15 R4-V R5-I R6-VIII G-15 R4 - V R5 -VI r6 - vm G-32 R4 -1 R5-VII R6 - V G-32 R4 -1 R5-XII R6-V G-32 R4 - IV R5 - VI R6-V G - 32 R4 - V R5 - VI R6 - V G-32 R4-VI R5-VII R6-V G-32 R4 - VI R5-XII R6-V G~40 R4-I R5-VII R6 - V G-40 R4-1 R5-XII R6 - V G~40 R4 - IV R5 - VI R6 - V G~40 R4-V R5 -VI R6 - V G-40 R4-VI R5-VII R6-V G-40 R4 - VI R5-XII RM G-53 R4-I R5-VII R6 - Vn G - 53 R4 -1 R5-XII R6-VII G-53 R4-IV R5-VI R6-VII G-53 R4 - V R5-VI R6-VII G-53 R4 - VI R5-XII R6-VII G-55 R4 -1 R5-VII R6-X G-55 R4 -1 R5'XII R6-X G-55 R4-IV R5'XIV R6 - X G - 55 R4-IV R5-XV R6-X G-55 RM'r R5-X1V R6 - X G - 55 R4 - V R5-XV R6-X
G -18 R4 - V R5 - XI R6-VIII G-18 R4-V R5-XIV R6-VIII G-23 RM R5 - V - G - 23 R4-I R5-VII - G - 23 R4 -1 R5-XII - G - 23 R4-1 R5-XIII - G - 23 R4-II R5-VII - G-23 R4-III R5-I - G - 23 R4-III R5 - II 一 G-23 R4-III R5-VI - G-23 R4 - IV R5-I · - G-23 R4-IV R5-VI * - G-23 R4-V R5 -1 - G-23 R4 - V R5-VI - G - 33 R4 -1 R5-VII R6-III G-33 R4 -1 R5-XII R6-III G-33 R4-IV R5-VI R6-III G-33 R4 - V R5-VI · R6-III G-33 R4-VI R5-VII R6-III G - 33 R4 - VI R5-XII R6-III G - 42 R4-I R5-VII K6 - V G_42 R4 -1 R5-XII R6-V G-42 R4 - IV R5 - VI R6 - V G-42 R4-V R5-VI Rf)-V G-42 R4 - VI R5-VII R6-V G-42 R4-VI R5-XII R6-V G-54 RM R5-VII R6-YII G-54 R4-I R5-XII R6-VII G-54 R4-IV R5 - VI R6-VII G-54 R4 - V R5 - VI R6-VII G-54 R4 - VI R5-XII R6-VII G-56 R4-I R5-VII R6-X G - 56 R4 -1 R5-XII R6-X G-56 R4-IV R5-XIV R6-X G-56 R4-IV R5 -XV R6-X G-56 R4_V R5-XIV R6-X G-56 R4-V R5-XV R6-X 108 314918
G- 71 R4 -1 R5-II R6-XI G-71 R4 -1 R5 - V R6 - XI G- 71 R4 -1 R5-VII R6-XI G-71 R4 -1 R5-IX R6-XI G-71 R4 -1 R5 - X R6 - XI G-71 R4-I R5-XI R6-XI G-71 R4-I R5-XII R6-XI G-71 R4 -1 R5-XIII R6 - XI G-71 R4-II R5-II R6 - XI G-71 R4 - II R5-IV R6 - XI G-71 RMI R5 - V R6-XI G-71 R4-II R5-VII R6-XI G-71 R4 - II R5-VIII R6-XI G-71 R4 - II R5 - IX R6 - XI G- 71 R4 - II R5-X R6 - XI G-71 R4 - II R5-XI R6 - XI G-71 R4-II R5-XII R6 - XI G-71 RMI R5-XIII R6 - XI G-71 R4-II R5-XIV R6-XI G-71 R4-III R5-II R6 - XI G-71 R4-III R5 - IV R6 - XI G-71 R4-III R5 - V R6 - XI G-71 R4-III R5-VII R6 - XI G-71 R4-III R5-VIII R6 - XI G-71 R4 - ΠΙ R5-IX R6-XI G-71 R4-III R5 - X R6-XI G-71 R4-III R5 - XI RMI G-71 R4-III R5-XII R6-XI G-71 R4-III RMIII R6-XI G-71 R4-III R5-XIV R6 - XI G-71 R4 - IV R5-II R6-XI G-71 R4-IV R5-IV R6-XI G-71 R4 - IV R5-VIII R6-XI G-71 R4 - IV R5 - IX R6 - XI G-71 R4-IV R5-X R6 - XI G-71 R4 - IV R5-XI R6-XI G-71 RMV R5-XIV R6 - XI
G-71 R4-V R5-VIII R6-XI G-71 R4-V R5-IX R6-XI G-71 R4 - V R5 - X R6-XI G- 71 R4 - V R5-XI R6 - XI G-71 R4-V R5-XIV R6 - XI G-71 R4-VI R5 - II R6-XI G-71 R4-VI R5 - V R6-XI G-71 R4 - VI R5-VII R6 - XI G-71 R4-VI R5-IX R6-XI G-71 R4 - VI R5 - X R6 - XI G-71 R4-VI R5-XI R6 - XI G-71 R4 - VI R5-XII ’R6-XI G-71 R4-VI R5-XIII R6 - XI G-71 R4-VII R5 - II R6 - XI G-71 R4-VII R5 - V R6-XI G-71 R4-VII R5-VII R6-XI G-71 R4-VII R5 - IX R6 - XI G-71 R4-VII R5 - X . R6-XI G-71 R4-VII R5-XI R6 - XI G- 71 R4-VII R5-XII R6-XI G-71 R4-VII R5-XIII R6 - XI G-71 r4 - vm R5-II R6 - XI G-71 mil R5-V R6-XI G-71 R4-VIII Mil R6-XI G-71 R4-VIII R5-VIII R6-XI G-71 R4-VIII R5-IX R6-XI G-71 R4-VI11 R5 - X R6-XI G-71 R4-VIII R5-XII R6-XI G-71 R4-VIII R5-XIII R6-XI G- 71 R4-VIII R5-XIV R6 - XI G-71 R4 - IX R5 - II R6 - XI G-71 R4-IX R5-IV R6 - XI G-71 R4-IX R5-V R6-XI G-71 R4-IX R5-VII R6-XI G-71 R4 - IX R5 - IX R6 - XI G-71 R4-IX R5-X R6-XI G-71 R4 - IX R5 - XI R6-XI 109 314918 200407073
G- 71 R4-V
G-71 R4-V
G- 71 RCIV
本發明化 製造法A
RMI R6.XI
R5-IV R6〜XI R5-XIV _ 合物例如可以 G-71 R4〜ΐχ G-71 R4〜ix G- 71 R4-y 藉由以下之2 R5-XII R6-xi R5-ΧΠΙ R6—XI R5 - 谓 R6-xn 法製造。
藉由使通式（4)表示之化合物[式中m Y、RH卜n表示與上述者相同之意義]^ 式（5)[式中，R3表示與上述者相同之意^表示之化 合物在對於該反應無活性之溶劑中或無溶劑下（在必要時 於催化劑之存在下）反應’可以得到在通式⑴中R1為氯居 子之通式（1-1)[式中，G、W丨、W2、X、γ、R2、R3、r4、 r5、r6、i、…表示與上述者相同之意義]表示之本發 明化合物。 反應基質之量，相對於通式（4)表示之化合物〗當量 可以使用1至50當量之通式（5)表示之化合物。 田 使用溶劑之情況，所用之溶劑若不會抑制反應之進 行，任一者皆可，例如苯、甲笨及二甲苯等芳香：烴類 314918 110 己燒及庚烷等脂肪族烴類，璟 二氣策笨苦夭B %己烷等脂環式烴類，氣苯及 一虱本寻方香族鹵化烴類，二 1，·二氯乙烧、U山三氣乙广坑1仿、四氯化碳、 肪族_化烴類、乙醚、丨，2_二 ”乙烯寺月曰 - 相 甲虱乙烷、四氫呋喃及1，4- 一 4烷寺醚類，乙酸乙酯及丙 胺、二甲基乙醯胺及N甲其2 D，二甲基甲酿 曱基-2-吼咯烷酮等醯胺 乙酸及丙酸等羧酸類，三乙胺、二 笙欧相叫A — 丁月女、N，N-二曱基苯胺 寺U，吼0疋及2-甲㈣ 醇等醇類，乙腈、二甲其四庶 土 礪、裱丁楓、1，3-二甲基_2-咪 嗤烧嗣及水專。此等溶劑可單 __ 剜』早獨使用，亦可將二種以上混 合使用。 使用催化劑之情況’彳以使用例如鹽酸、硫酸及硝酸 等礦酉夂—：酉夂、乙酸、丙酸、三氟乙酸、甲磺酸、苯磺酸 及、寸甲苯’、酉夂等有機酸’二乙胺鹽酸鹽及吡啶鹽酸鹽等胺 方員之4 ^成现，以及氯化鋅、碘化鋅、四氯化鈦、氯化鈽、 三乳甲石頁酸镱及三氟化硼·醚配位化合物等路易士酸做為 反應催化劑，其之使用量相當於通式（4)表示之化合物之 0.001至1當量。 反應/里度’可以设定為從_6〇它至反應混合物之回流溫 度中之=何溫度’反應時間，雖視反應基質之濃度及反應 ✓皿度而又化’但通常可在5分鐘至1 〇 〇小時之範圍内任意 設定° 一 I而言’以在下列條件下進行反應為較佳：例如相 對於通式（4)表示之化合物1當量，使用1至當量之通 111 314918 200407073 式（5 )表示之化合物，不使用溶齊I]或使用四氧D夫喃或1，心二 噚烷等溶劑，在50。(：至反應混合物之回流溫度之溫度範圍 内，進行3 0分鐘至20小時之反應。
製造法B
(1-2) 藉由使通式（6)表示之化合物[式中，G、、
R4、R5、R6、l、m月主 t Y 中述者相同之意義]與通式（5)[ Α 示與上述者相同之意義]表示之化合物在 衣k法Α同樣之條 切在 氧原子且 ^件下反應’可以得到在通式⑴中W2
R2、R3、R4 7原子之通式㈣[式中，G、W、X、Y
表示之本發明化合：:、…表示與上述者相同之意^ 製造法C 314918 112 200407073
⑻
(1-3) 藉由使通式（7)表示之化合物[式中，W2、X、R3及m 表示與上述者相同之意義]與通式（8)[式中，G'Y'R1、 R4、R5、R6、1及η表示與上述者相同之意義]表示之化合 物在與製造法Α同樣之條件下反應，可以得到在通式（I) 中W2為氧原子且R2為氫原子之通式（1-3)[式中，G、W2、 X、Y、R1、R3、R4、R5、R6、1、m及η表示與上述者相 同之意義]表示之本發明化合物。
製造法D
(9) (5)
113 314918 200407073 藉由使通式（9)表示之化合物[式中’ G、wl、χ、γ、 r1 m卜。及η表示與上述者相同之意義]盥 通式（5)[式中，R2及R3表示與上述者相同 、 J、思我j表示之 化合物，在對於該反應無活性之溶劑中或無溶劑下，使用 縮合劑(在必要時可於驗存在下)進行反應，可以得到在通 式（I)中W2為氧原子之通式（1-4)[式中，g、W1 ν …表示盘上述者:χ门Y、R1、 一 一上边者相同之意義 所表示之本發明化合物。 反應基質之量，相對於通式（9)所表示之化人物1 A 量，可以使用！至100當量之通式⑺所表示之;3匕合^ 縮合劑，若為通常醯胺合成所使用者，將無特殊限制， 例如可以使用向山試藥（2_氯4甲基吼鏡峨化物）、咖 (1，3-二氯己基碳化二亞胺)、wsc(i_乙基二甲胺 基）碳化二亞胺鹽酸鹽）、CDI(羰基二咪唑 土 鎏溴化物、丙炔基：茉其4&quot;儿私 —Τ基丙烯基 土 —本基心臭化物及DEPC(氰基•二乙 酉曰）等’其之使用量相對一 當量。 祁對於通式（Μ表不之化合物為丨至4 進行使Γ=Γ，所使用之溶劑只要不會抑制反應之 % ρ ^ 為本、甲本及二甲苯等芳香族_ 類，己烷及庚烷等脂肪族_ n〆, 原焱類，壞己烷等脂環式烴類，氣 本及一氣苯等芳香族南化 、、 〇 G 4力員，—虱甲烷、氯仿、四氣化 石反、】上二氯乙烷、1 1 1 — ^ 四乳化 ^ _ ，—虱乙烷、二氣乙烯及四負r鯈 寺月曰肪族_化烴類、乙醚 虱乙烯 1 4 - π- ^ Λ. ，2_一甲乳乙烷、四氫呋喃及 ，专统㈣類’乙酸乙醋及丙酸乙醋等醋類，二甲基 1】4 314918 200407073 T 胺、二曱基乙醯胺及N_曱基_2_吼咯烷酮等醯胺類， 二乙胺、三丁胺、N，N_二甲基苯胺等胺類，吡啶及2_甲基 吼σ疋等吼咬類，乙腈及二曱基亞楓等，此等溶劑可單獨使 用’亦可將二種以上混合使用。 驗之添加可需要或不需要，不過在使用鹼之情況，所 用之鹼例如為氫氧化鈉及氫氧化鉀等鹼金屬氫氧化物，碳 酸鈉、碳酸鉀及碳酸氫鈉等鹼金屬碳酸鹽，三乙胺、三丁 胺、Ν，Ν-二曱基苯胺、吡啶、4-(二甲胺基）吼啶、咪唑及 1，8-二氮雜雙環[5·4〇]-7-十一烯等有機鹼等，其之使用 里’相對於通式（9)所表示之化合物，為1至4當量。 反應溫度’可以設定為從-60°C至反應混合物之回流溫 度中之任何溫度，反應時間，雖視反應基質之濃度及反應 溫度而變化，但通常可在5分鐘至100小時之範圍内任意 設定。 一般而5，以在下列條件下進行反應為較佳：例如相 對於以通式（9)表示之化合物丨當量，使用丨至2〇當量之 以通式（5)表示之化合物以及i至4當量之WS(：(i•乙基 (3-二甲胺丙基）-碳化二亞胺鹽酸鹽及CDI(羰基二咪唑）等 縮合劑’而要日才可存在1至4當量之碳酸鉀、三乙胺、吡 啶及4-(一曱胺基）吡啶等鹼，無溶劑或使用二氯甲烷、氯 仿、乙醚、四氫呋喃及丨，扣二噚烷等溶劑，在〇。〇至此等
溶劑之回流溫度之範圍内進行10分鐘至24小時之反應。 製造法E 115 314918 200407073
藉由使通式（10)表示之化合物[式中，W2、X、R2、R3 及m表示與上述者相同之意義]與通式（8)[式中，G、Y、 R1、R4、R5、R6、1及η表示與上述者相同之意義]表示之 化合物在與製造法D同樣之條件下反應，可以得到在通式 (I)中W1為氧原子之通式（1-5)[式中，G、W2、X、Υ、R1、 R2、R3、R4、R5、R6、卜m及η表示與上述者相同之意義]
表示之本發明化合物。 製造法F
藉由將通式（II)表示之化合物[式中，X、R3及m表示 116 314918 200407073 與上述者相同之意義]依照文獻公知之
Rev· 1990 年，类。 / 例如 Chem. 年，9〇卷，879頁等記载之方 性鋰化後，盥通4 進仃位置選揭 ”通式（12)[式中，G、、γ、r4 “ 及η表示與上述者 、、R、 仰丨j之思義]表不之化入 到在通式φ w2 ☆斤 σ物反應，可以得
、飞⑴中W為氧原子且R 6)[式中 WX、Y、r3、r4、r5、r6'〜^ :與上述者相同之意義]表示之本發明化合物：：= 又示丁基鋰等烷基鋰試藥。
製造法G
^ (1-7) 精由使通式（13)表示之化合物[式中，〇、χ、 R5、R6、卜 Κ Λ 及η表示與上述者相同之意義]與通式 中’ W2及R3主-t ’L式 制 、不共上述者相同之意義]表示之化合物在與
A法F同樣之條件下反應’可以得到在通式⑴中W 氧原子且R1及R2兔$盾 —…、 人八马虱原子之通式（1-7)[式中，g、W2、 Y T3 3 4 入、 、R、尺5、尺6、1、111及11表示與上述者相同之咅義 j不之本發明化合物。又，R-Li表示丁基鋰等烷基鋰試· 314918 117 200407073 製造法Η
精由使通式⑴中氧原子 (I，[式中，G、W2、χ、γ 3為風原子之通式 月 η 矣 _ t R、R4、R5、R6、1、m 及η表不與上述者相同之意義 t , Ri . ]表不之本發明化合物與通 脫離二 與上述者相同之意義，J1表示… 脫離基如氯原子、溴
乙醯4其、广 /、原子、Cy烷羰氧基（三f J 土）、匸】-4烷磺醯基（例如 石甚硫I /μ, ’八^乳D、Ci_4鹵代烧 石只I基（例如三氟T磺醯氧 其、 J方、驗基（例如苯磺醯氧 ==甲本續醯氧基）或唾基（例如❹小基）】表示之化合 ==在必要時可存在驗基以及於必要時可使用對該反 ^二、「 劑），可以㈣在通式⑴中W】為氧原子之通 式（W)[式中，G、W2、X、Y、R】、r2、r3、r4、r5 r6、 表示與上述者相同之意義]所表示之本發明化合 物0
反應基質之量’相對於通式㈣表示之化合物！當 可以使用1至50當量之通式（15)表示之化合物。 使用溶劑之情況，只要所用之溶劑不會妨礙反應之進 314918 ]18 407073 行’任-者皆可，例如苯、甲苯及二甲 己烷及庚烷等脂肪族&gt; . s私蛵類， 矢4類，壞己烷等脂環式烴 二氯苯等芳香族南化，_胃¥ p 飞二頦，虱苯及 c心颂，一虱甲烷、氯仿、四 1，2-二氣乙烷、二友 一斤 乳化石反、 ，一虱乙烷、二氣乙烯及四氯乙 肪族鹵化烴類、乙鍵 、烯寺月曰 1，2-一甲虱乙烷、四氫呋 二噚烷等醚類，乙酸乙 雨及1，4- 吸C S曰及丙酸乙酯等酯類，二 胺、二甲基乙醯胺及Na 土甲fe ^ 夂N-甲基-2-口比咯烷酮等醯胺類，三乙 ^ 丁胺N，N•—甲基苯胺等胺類，吡啶及2_甲基 等㈣員’甲_、乙醇及乙二醇等醇類，乙腈、二甲基比亞疋 楓、ί衣丁楓、1，3_二甲基丄咪唑烷酮及水等。此等溶劑可 單獨使用，亦可將二種以上混合使用。 在使用鹼之情况，所用之鹼例如為氫化鈉及氫化鉀等 鹼孟屬氫化物，氫氧化鈉及氫氧化鉀等鹼金屬氫氧化物， 乙氧化鈉及弟一丁氧氧化鉀等驗金屬烧氧化物，二異丙酸 月女鋰、六甲基二矽氮烷鋰及醯胺鈉等鹼金屬醯胺類，第三 丁基鋰等有機金屬化合物，碳酸鈉、碳酸鉀及碳酸氫鈉等 鹼金屬碳酸鹽，三乙胺、三丁胺、Ν，Ν_二甲基苯胺、吡啶、 4-(二甲胺基）口比啶、咪唑及ι8_二氮雜二環[5·4 〇]-7-十一 烯等有機驗等，相對於通式所表示之化合物，其使用 量為1至4當量。 反應溫度，可以設定為從_6〇°c至反應混合物之回流溫 度中之任何溫度，反應時間，雖視反應基質之濃度及反應 溫度而變化，但通常可在5分鐘至1 〇〇小時之範圍内任意 設定° 1]9 314918 200407073 一般而言，以在下列條件下進行反應為較佳：例如相 對於以通式（1-8)表示之化合物i當量，使用i至1〇當量之 以通式（I5)表示之化合物，在四氫呋喃、丨，4-二卩萼烷、乙腈 及N，N-二甲基曱醯胺等極性溶劑中進行，必要時可使用諸 如氫化鈉、第三丁氧化鉀、A氧化鉀、碳酸鉀、三乙胺及 :啶等之鹼，其量相對於以通式(1，表示之化合物工當 里為1至3當！，以及在〇至9〇〇c之溫度範圍内進行 分鐘至24小時之反應。
製造法I
藉由使在通式⑴中w2炎_店π 〇 W為虱原子且r2為氯 (1-9)[式中，G、wi、χ ^ Χ Υ、R】、R3、R4、R5、R6、i、】 及n表示與上述者相同 之思義]表不之本發明化合物與诵 式（16)[式中，y及ji表示盥 ^ ^ ^ ^ ^ ^ , /、上11者相同之意義]表示之4 a物在與1造法η同樣 ,^ ^ 饰仟 &gt; 反應，可以得到在通式（ 中W為氧原子之通式（ I 式仏4)[式中，G、W】、X、Y、r1、r2 R 、 R 、 R5 、 r6 、 j 、 01及n表示與上述者相 示之本發明化合物。 々心義]表 314918 120 200407073
製造法J
(1-10) R5 V=N—OH J2
(18) 藉由使通式（17)[式中，wl、W2、x y ri r2 r3、 R4、R6a、R6b、茁 表不與上述者相同之意義]表示之化 合物與通式（18)[式中，R5本一命L丄 玩千R表不與上述者相同之意義，以及 表不氫原子，或者氯原子及漠原子等_素原子]表示之化 合物，依照文獻[如如㈣―Η%年，a卷，pH頁； J. Heterocyclic Chem., 199〇 ^ ^ 27 4 &gt; 769 I ； Justus
Liebigs Ann‘ Chem·，1989 年，985 頁；丁咖㈣而： 切__，1997 年，8 卷，245 頁；TetrhedronLett•，蘭 年’ 27卷’ 4647頁；國際公開WO01/12613號公報及WO 02/076956號公報]記載之方法反應’ 或者藉由通式（17)表示之化合物與通式（19)[式中R5 表不與上述者相同之意義]表示之化合物依照文獻[Chem. ’ 1990 年 559 頁；Synthesis, 1997 年，309 頁；Synth. C〇mmun.，1988年，18卷，23i5頁]記載之方法反應， 可以得到在通式（I)中 G為G-7之通式（1_10)[式中，W1、 121 314918 200407073 m及 W χ、γ、Rl、r2、RJ、r4、r5、R6a、 與上述者相同之意義]表示之化合物。 在製造法A至製造法j中，對於反應終了後 合物進行戶斤士田「古4立、曲^ &lt;反應斤匕 明直接滾、，値，或者於溶於有機溶劑及水洗後 卜、、§或者投入冰水並用有機溶劑萃取後濃縮 德虛理，4又的 可以得到目的之本發明化合物。又， 可以驻Α π 而聲精製時， 一 9 結晶、管柱層析、薄層層析、液體層析分取箄 任思之精製方法分離及精製。 寻 即通=製造法Α中，供製造本發明化合物之原料化合物， 弋（4)表不之化合物以及通式（4)中w】及W2為氧原子 且（X)m為3位硝基之通式（2)表示之化合物可如卞述合成。 反應式1
122 314918 200407073
亦即’藉由將通式（20)[式中’ X及m表示與上述者相 同之思義]表示之化合物與為通式（8)中ri為氫原子之通式 (8-1)[式中，G、Y、R4、R5、R6、丨及η表示與上述者相同 之意義]表示之化合物，依照文獻記載之公知方法[例如 Dtsch. Chem· Ges” 19〇7 年，40 卷，3m 頁；】s〇c， 1954 年 ’ 2023 頁，J· Chem· Soc· Perkin Trans. 1，1994 年， 2975頁等記載之方法]反應，可以容易地合成通式（句中f 及W2為氧原子之通式（4_υ[式中，〇、X、γ、R4、r5、r6、 1、m及n表示與上述者相同之意義]表示之化合物。 又，藉由將市售之3-硝基酞酸酐（2〇_1}與通式（3)[式 中：G、Υ1、…、“、丨及^表示與上述者相： 之意義]表示之化合物在同樣之條件下反應，可以合成通式 (2)[式中 ’ G、X、Υ】、γ2、R4、R5、R6、卜 m &amp; ηΐ 表示 與上述者相同之意義]表示之化合物。 _製造法A、製造法B及製造法D所使用之通式⑺所表 示之化合物之某些為公知之化合物，一部分可從市售品得 到又，此外可依照Chem. Pharm. Bull. 1982年，30卷， 314918 123 200407073 1921 頁；J· Am· Chem. Soc.，1986 年，1〇8 卷 國際公開公報（W〇 01/23350號公報）等 3811頁及 占丨 J寻5己载之方法w菸办 獻記載之其他丨級或2級烷胺類各個一 成。 一叙合成方法合 、在製造法B中，供製造本發明化合物之原料化合物， 即通式（6)表示之化合物可如下述合成。 反應式2
-H20
(X)m 、0 W1 ㈣ (6) 亦即，藉由將通式（9)中Ri為氫原子之通式（9_ι}[式 中，G、Wi、X、Υ、R4、R5、r6、】、m 苁 . K 1 m及η表示與上述者 相同之意義]表示之化合物進行文獻記載之一般脫水環化 合成異醯胺之反應，例如依照j. Am. Chem. Soc·, 1975年， 97 卷，5582 頁；J. Med· Chem·，1967 年，1〇 卷，982 頁· J· Org. Chem·，1963年，28卷，2018頁等記載之方法進疒 環化，可容易地合成通式（6)[式中，G、w1、X、γ、R4 R5、R6、1、m及η表示與上述者相同之意義]表示之化八 物。 在製造法C中，供製造本發明化合物之原料化合物， 即通式（7)表示之化合物可如下述合成。 3]49]8 124 200407073 反應式3
亦即，藉由使通式（10)中R2為氫原子之通式（1〇_1}[式 中 W2、X、R3&amp;m表示與上述者相同之意義]表示之化 一物進行與反應式2同樣之反應，可以容易地合成通式（7) [式中，W2、X、R3及m表示與上述者相同之意義]表示之 化合物。 在製造法C及製造法E中所使用之通式（8)表示之化合 物及通式（3)表示之化合物，例如可以使用下述反應式4至 反應式16表示之方法等合成。 R5
V=N〜〇H
(21)
(8-2) J2 (18) —»· (R、CH2N〇2、 V (19&gt; ) 猎由使通式（2υ[式中，Y、Rl、R4、R6ann; 示與上述者相同之意義，P表示乙醯基、特戍醢基、节i 基、弟二丁氧幾基及〒氧纟 _ ^ 一 1孔放基寺一般所使用之胺基之保 基]表示之化合物，與通式（18)[式中，】2表示與上 314918 125 200407073 者相同之意義]表示之化合物， 上述者相同之意義]表示之化 5(19狀中，R5表示與 件下反應，形成異^與製造法J同樣之條 m w ^ 對於各個保護基以一般使 2M式中，丫、6^、二(二中〇為“之通式(8- 同之意義]表示之化合物。 及η表示與上述者相 反應式5
(24) 藉由將通式（22)[式中，γ、R丨、R4、R6a、_、 (25)j (Y)n R4〇
n及P 表示與上述者相同之意義]表示之化合物與通、^ 中，R5表不與上述者相同之意義，以及R表示[式 等低級烷基]表不之化合物，依照文獻記載之方法=乙基 照Chem. Ber.，1958年，91卷，1098頁等記載之方J如依 々冼縮合 3M918 126 200407073 後對於各個保護基以一般使用《方法脫保護，可以得到 通6式（8)中G為G-13之通式（8-3)[式中，γ、R1、R4、R5、 R6、心及η表示與上述者相同之意義]表示之化合物。 、或者藉由將通式（22)表示之化合物與公知之通式（24) [式中，R5表示與上述者相同之意義，j3表示脫離基，諸如 子、Cl·4烧氧基（例如甲氧基及乙氧基）、彡氧基（例 如本虱基）、Cl·4烷羰氧基（例如特戊醯氧基）或Ci 4烷氧羰 氧基（例如異丁氧羰氧基）]表示之化合物或公知之通式（25) [式中’ R表不與上述者相同之意義]表示之化合物，依照 文獻記載之一般胺之醯化反應[例如依照J. Am. chem. S〇c·，2_ 年，122 卷，2149 頁；Tetrahedr〇n: Asymmetry， 1993年，4卷，205頁及國際公開公報（w〇 99/24393號公 報）。己載之方法]進行反應，得到通式（26)[式中，Y、r1、Μ、 R、汉63、化6、！1及1&gt;表示與上述者相同之意義]表示之化 。物’將其依照文獻公知之方法[例如依照Ber Dtsch hem· Ges·，1940 年 ’ 73 卷，656 頁；J. Heterocyclic Chem·， 2〇00年’ 37卷’ 343頁及歐洲專利公報（EP 0 895 992號公 報）等記載之方法]進行脫水環化，形成噚唑啉環後，對於 各個保護基以一般使用之方法脫保護，可以得到通式（8_3) 表示之化合物。 其中所使用之通式（23)表示之化合物為公知之化合 物 部分可以市售品得到。又，此以外者，可以依照文 獻。己載之公知方法’例如Chem Ber· 1959年，92卷，330 頁及 1985 年，118 卷，3089 頁以及 J· Am. Chem· Soc·，1948 127 314918 200407073 年，70卷 反應式6 165頁等記載 之方法容易地合成
㈣） 藉由將通式（27)[式中，γ、 與上述者相同之意義，j4# 表不 漠原子、峨原子、…酿基(例如&quot;醯氧二子、 ，基續酸基(例如三氣甲_基)或芳續酸基(例： 本石頁酸氧基、對-甲苯碏醯氧 +八EU乳基）]表示之化合物，依照文獻 記載之公知方法[例如依照BuU. Chem· s〇e. 一 1996年， 69卷’ 3345頁及德國專利公報⑽⑼sms ?虎公報）等記 載之方法]形成啊啉環後’對於各個保護基以—般使用之 方法脫保護，可以得到通式⑷中〇為GW且r“及R6f 為51原子之通式（8·4)[式中，YH、R5及η表示與上 述者相同之意義]表示之化合物。 反應式7
(S-5) 314918 128 200407073 藉由將通式（26)[式中，γ、、r4、r5、R“、R6b、η jp 一 、 八/、上述者相同之意義]表示之化合物，依照文獻記 載之A知方法[例如J·〇rg· Chem·，1997年，62卷，1106 頁等兮己'Mi : 之方法]與五硫化一碟或勞森試劑等反應，形成噻 唾，環後，對於各個保護基以_般使用之方法脫保護，可 以$付，通式（8)中G為G-17之通式（8 — 5)[式中，y、r1、r4、 R R 、Rb&amp;n表示與上述者相同之意義]表示之化合物。 反應式8 〇〇, R4
NH R5 R6a R«b (28)
p2s5 OH
NC -R5 X (30) /-P (8·6)
(29) 藉由將通式（28)[式中，Y、Rl、r4、r5、R6a ' R6b、n 及p表示與上述者相同之意義]表示之化合物，依照文獻記 載之公知方法[例如德國專利公報（DE 19528778號公報）等 圮載之方法]與五硫化二磷或勞森試劑等反應，形成噻唑啉 129 314918 τ後對於各個保護基以一般使用之方、# Βί? / β 到通式(8)中Γ “ 另又使用之方法脫保護’可以得 R6a、R6b 〜_18 之通式（8·6)[式中，Y、Rl、Rl R5、 式本及1表不與上述者相同之意義]表示之化合物。 _’藉由將通式（29)[式中，Y、R1、R4、R6a、R6b、 與上述者相同之意義]表示之化合物與公知之通 ilR5表示與上述者相同之意義]表示之化合 物依知文獻記載之方法「你口 τ ^ 卷，U47 頁等 〇rg.Chem·，1960 年，25 各個保護基以使用=反應’形成噻哇啉環後，對於 表示之化合物。又法脫保護，可以得到通式（8-6) 反應式9
一藉由將通式（31)[式中，Y、RI、R4、R5、R6am 表不舁上6述者相同之意義]表示之化合物與公知之通式(32 [式中，R6e表示血上咸本 &quot; ^ I者相同之思義]表示之肼化合物，依 314918 130 200407073 照文獻記載之方法[例如j· Chem s〇c，i964年，6〇72頁等
載之方法]反應，形成吼。坐琳環後，對於各個保護其以一 =使用之方法脫保護’可以得到通式⑻中G為G-U^R6b 為虱原子之通式（8_7)[式中，Y、Rl、R4R5、R6a、R 表示與上述者相同之意義]表示之化合物。 η 藉由將通式⑴）表示之化合物與公知 中，表示與上述者相同之意 M33)[式 文獻記載之方法[例如，j 合物，依照 发 m 百yChCChem.，l989 年，26 卷，251頁寺]反應，形成3,4_二氯㈣環後， 護基以-般使用之方法脫保護，可以得到 /個保 Μ3且以為氫原子之通式㈣[式中，Y、R1 ^為 R6a、r6c及n表示金 、R5、 反應式1〇 …者相同之意義]表示之化合物。
藉由將通式（34)[式中，γ、R1、&amp;、 述者相同之意義]表示之化合物與通式V: 14示與」 表示與上述者相同之意義]或通式（19)[式中中，反5及 述者相同之意義]表示之化合物，在與製，R5表示與 下反應，形成二噚唑啉環後，對於各個：:】同樣之條 之方法脫保護，可以得到通式、\土以〜般使 马 &gt;、s 之通式（8- 314918 131 200407073 [式中，Y、R 示之化合物。 反應式11 R4、R5及η表示與上述者相同之意義]表
(8-10) 將通式（34)[式中，γ、、r4 相同之音墓^- 及p表不與上述： 述者相；；]表示之化合物與通式（35)[式中，R5表示與 法[例/之意義]表示之化合物’依照文獻記載之公知之 可 em.Lett·，1998年，U9頁等記載之方法]反應 了以侍到通式（36)[式中，γ 八 Κ 、η及Ρ主一 上述者相同之咅差1车- 又不 表不之化合物，將其依照文獻記载之 知之方法[例如 TetrahedronLettl992 h ^之 等記載之方法]，經由通式（37)[式中 及…與上述者相同之意義]表示 、 成 保護 成:，5_二氣物，對於各個保護基以一般使用：：ι 曼，可以得到通式（8)令 法月 15之通式（8^〇)f式中： 3M9I8 132 200407073 Y、R1、R4、R5及η表示與上述者相同之意義]表*之化人 物。 σ 其中所使用之通式（35)表示之化合物為公知化合物， -部分為市售品…除此以外者，依照文獻記栽：公知 方法[例如依照 Chem. Pharm. Bull·, 1965 年，13 卷， 頁等記載之方法]易從對應之公知胺基酸合成。 反應式1 2
(21_1) \ (39) f (8·11).
[式中==) 子之通式⑺， 之化合物與通式⑽[式中/Rr及=者相；1之意義⑷ 意義]表示之化合物，依 ，、上述者相心 j Chem Sop rv, ^载之公知方法[例如依照
Soc. Chem. C〇mmun 法]反應，形成45 _·，987年，919頁等記載之j 少月乂 4，：)- 一氧□夫喃環， 用之方法脫保護，可以得 ⑻中°個保護基以-般右 ⑴[式中，Y、ri、r4 r5式（8)中G為G-l之通式（8 八 KR、R6c 另 * 一 意義]表示之化合物。 &amp;示與上述者相同之 或者藉由將通式（21_ [式中…表示與上述者相同C與公知之通式(3 J足思義，以及表示烷氧美 314918 133 200407073 基及氰基等電子吸引基]表示之化合物，依照文獻記載之公 知方法[例如依照 Tetrahedron Lett·，1996 年，37 卷，4949 頁等記載之方法]反應，可以得到通式（8-11)中R6。表示電 子吸引基之化合物。 其中所使用之通式（38)表示之化合物為公知化合物， 又’除此以外者，依照文獻記載之公知方法[例如依照Chem.
Lett·，1981 年，1135 頁及 J. 〇rg. Chem·，1992 年，57 卷， 45 55頁記載之方法]可容易地合成。 再者’通式（39)表示之化合物為公知化合物，一部分 為市售品。又，除此以外者，依照文獻記载之公知方法[例 如依照 J. Heterocyclic Chem·，1984 年，21 卷，1849 頁及 J· Med· Chem·，1979年，22卷，1385頁等記載之方法]容 易地合成。 反應式1 3
藉由將通式（34)[式，
表示與上述者相 之思義]表示之价 相同之意義]表示
314918 334 200407073 头方法[例如，依照Synthesis，1 983年，203頁，曰本專 利公開公報（jp 06/092957號公報）及；Flu〇rine chem 1989年，44卷，377頁等記载之方法]反應，形成二氧雜 =裱後，、對於各個保護基以一般使用之方法脫保護，可以 ^到通式（8)中G為G-55之通式（8_12)[式中，γ、R】、r4、 R及η表示與上述者相同之意義]表示之化合物。 立=中所使用之通式（40)表示之化合物為公知化合物， 邛分為市售品。又，除此以外者，依照文獻記載之公知 方法[例如依照 J.Am.Chem.s〇c.，1966 l884,2i94 頁，、Madron Lett·，1995 年，36 卷，3277 頁及 2_ 年， 卷7847頁等記載之方法]，可容易地合成。 又，通式（41)表示之化合物為公知化合物，又，除此 以外者，依照文獻記載之公知方法[例如依照Jchem s〇c
Perkin Trans」，1983 年，3〇2〇 頁等 ， 干貝4圮載之方法]可容易地 合成。 反應式1 4 R6a Rib
(42)
(8-13) 藉由將通式（21)[式中，Y、Ri、R4、R 表示與上述者相同之意義]表示之化合物與通式（42)[式 中’ R6C表不可被（Z2)p]取代之苯基]表示之 R(
η及P 化合物，依照文 314918 135 200407073 獻記載之A 士、丄r A知方法[例如依照J· Org· Chem·，1971年，36 卷’ 3316頁等記載之方法]反應，形成3,4-二氫-2H-吡咯 衣然後對於各個保護基以一般使用之方法脫保護，可以 付到通式（8)中G為G-6且R5為氫原子之通式（8_13)[式 中，Y、R1、Μ、R“，及n表示與上述者相同之意義， 以及R6e表示可被（Ζ2)ρ1取代之苯基]表示之化合物。 其中所使用之通式（42)表示之化合物為公知化合物， 一部分為市售品。又，除此以外者，可依照文獻記載之公 知方法[例如依照Angew· Chem·，1965年，77卷，492頁，
Chem.Ber.，1960年，93卷，239頁等記載之方法]容易地 合成。 反應式1 5 314918 136 200407073 ch2i2 _ p
R6i
(8-14)
(8-15)
(8· 16)
(8-17) 藉由將通式（43)[式中，γ、R]、R4、R5、R6i、n及p 表示與上述者相同之意義]表示之化合物及二碘曱烷依照 文獻把載之公知方法[例如Chem· Pharm· Bull·，1992年， 〜卷3 1 8 9頁等記載之方法]反應，形成環丙烷環後，對 :::保護基以一般使用之方法脫保護，可以得到通細 為G-7!且及為氫原子之通式（8·】q[式中，γ、
5J491S 137 200407073 R1、R4、R5 ’ R61及η表不與上述者相同之意義]表示之化 合物。 又，藉由將通式（43)表示之化合物，依照文獻記載之 公知方法[例如依照Tetrahedron, 1979年，35卷，1919頁· Tetrahedron Lett.，1975年，1820頁等記載之方法]與氟二 碘曱烷反應，或者依照文獻記載之公知方法[例如依照j.
Org. Chem.，1994 年，59 卷 ’ 4087 頁；Tetrahedron，197〇 年，26 卷，4203 頁；及 Tetrahedron Lett., 1987 年，28 卷， 5075頁記載之方法]與二氯曱烷或二溴甲烷反應，可以得 到通式（8)中G為G-7 1且RQ為氫原子之通式（8_丨5)[式中， Y、R1、R4、R5，及n表示與上述者相同之意義以及 R6j表示氟原子、氯原子或溴原子]表示之化合物。 或者，藉由將通式（43)表示之化合物與六氟_丨，2_環氧 丙烷或公知之通式（44)[式中，及Rek各自獨立，表示氟 j子、氣原子或漠原子，J5表示氫原子、氣原子或漠原子 等以及J表不氣原子、溴原子、羧基或烷氧羰基等]表 示之化合物，依照文獻記載之公知方法[例如依照J chem S〇c·，Perkin Trans· 1995 年，653 頁；】〇rg 以⑽，i964 年，29 卷，1 886 頁’ 1986 年，51 卷，974 頁及 i99〇 年， Μ 卷，5420 頁；Tetrahedr〇n，1989 年，45 卷，2925 頁， Β9〇年，46卷，1911頁及1999年，55卷丨〇325頁； Tetrahedr〇n, Lett，1971 年，3869 頁，1988 年，π 卷，67钩 頁及1998年，39卷’ 3〇13胃等記栽之方法]反應可以得 到通式（8)中G為G-71之通式（8-16)[式中，γ、R,、R4、 314918 138 200407073 R5 ’ R61及η表示與上述者相同之意義，以及r6」·及rq各 自獨立，表示氟原子、氯原子或溴原子]表示之化合物。 再者’藉由將通式（43)表示之化合物與公知之丙二腈 衍生物，依照文獻記載之公知方法[例如依照j. Chem. s〇c.
Chem· Commun·，1989 年 ’ 1286 頁，丁etrahedron lett 1966 年，1415頁等記載之方法]反應，可以得到通式（8)中G為 G 71’且Rj及r為氰基之通式（8_17)[式中，y、r]、r4、 R ’R61及η表示與上述者相同之意義]表示之化合物。 反應式1 6
藉由將通式（45)[式中，γ、Ri、R4、R6j、R6k、η及ρ 表不與上述者相同之意義]表示之化合物與通式（4 ό)[式 :R表不可被G2)?1取代之苯基，R6i表示氫原子或烷氧 羰基等，J7表示:基或=NNHS〇2Ph_4_CH3基等]表示 之化口物，用文獻記載之一般铑催化劑進行加成反應，例 友…、J· Am· Chem· Soc· 2001 年，123 卷，2695 頁以及 =際公開公報（W0 98/347〇號公報）等記載之方法進行反 應，或者藉由將通式（45)表示之化合物及通式（47)[式中， 表丁可被（Z )p]取代之苯基，R6!表示氟原子、氣原子或 314918 139 200407073 溴原子，以及J8表示氣原子或溴原子]表示之化合物，依 照文獻§己載之公知方法[例如依照J · 〇 r g · C h e m ·，1 9 6 2年， 27 卷，2685 頁；Tetrahedron Lett” 1965 年，3445 頁及 1968 年，1 1 962頁等記載之方法]反應，形成環丙烷環後，對於 各個保護基以一般使用之方法脫保護，可以得到通式（8) 中〇為〇-71之通式（8-16)[式中，丫、尺1、114、1^、1161^及 η表示與上述者相同之意義，R5表示可被（Z2)pi取代之苯 基，以及R61表示氫原子、氟原子、氯原子、溴原子或烷 氧幾基]表示之化合物。 其中所使用之通式（46)表示之化合物及通式（47)表示 之化合物，分別依照對應之上述文獻記載之方法合成。 在製造法D中，供製造本發明化合物之原料化合物， 即通式（9)表示之化合物，例如可以用下述反應式1 7或反 應式1 8所示之方法合成。 反應式1 7
藉由將通式（20)[式中，X及m表示與上述者相同之意 義]表示之化合物與通式（8)[式中，G、Y、R1、R、R5、r6、 314918 140 200407073 1及η表示與上述者相同之竟羞 ^ 表不之化合物在盘掌』造法 A同樣之條件下反應，可以 在，、衣仏汝 〈于^通式（巧中wl 通式（9-2)[式中，G、X、γ、Ri 4 ’、 R、R4、R5、R6、！、m 及 n 表不與上述者相同之意義]表示之化合物。 反應式1 8
m I ^j&gt;£C Μΰ ν lax -r 載之公知方法[例如依照Chem. Rev.，199〇年，9〇卷，879 頁等記載之方法]進行位置選擇性鐘化後，與二氧化礙反 應，可以得到通式（9)中W1 A氧原子且RU氫原子之通式 (9_3)[式中’ G、X、Y、R4、r5、R6、卜m及n表示與上 述者相同之意義]表示之化合物。X，R-Li |示丁基裡等 烷基鋰試藥。 在製造法E中，供製造本發明化合物用之原料化合 物’即通式（1 〇)表示之化合物，例如可以使用下述之反應 式19或反應式2〇表示之方法等合成。 反應式1 9 141 314918
糟由將通式（20)[式中， 義]表示之化合物與通式 m表示與上述者相同之
相同之意義]表示之化人你/ ，R2及R3表示與上述$ 應，可以得到通式(10);與製造法A同樣之條件下万 表示與上述者=子:通式⑽術 反應式20 同之意義]表不之化合物
Η 、R3
C〇2 (11)
藉由將通式（11)[式中，χ、 之咅羞！本- 及m表不與上述者 得到诵々， 仃”反應式12同樣之反應， 、式（10)中W為氧原子且r2 [式中，γ γ Κ為虱原子之通式（1( 物。又R、。及m表示與上述者相同之意義]表示之 ，R-U表示丁基鋰等烷基鋰試藥。 在i k法F中’供製造本發明化八私田 物，即通々m、本- 月化合物用之原料化 分可;^古I 一馮A知化合物，一 J处市售品獲得。又，除此以外 卜者亦可依照文獻！ 3J49I8 142 200407073 之公知方法[例如依照Bull. Chem. Soc· Jpn·，1985年，58 卷，3291 頁，J· 〇rg· Chem·，1991 年，56 卷，2395 頁， Tetrahedron Lett·，1994 年，35 卷，2113 頁及國際公開公 報（WO 98/23581號公報）等記載之方法]容易地合成。 製造法F所用之通式（12)表示之化合物可以如下述合 成。 反應式2 1
W1 crc、a (48) 或光氣對等物
亦即，藉由將通式（8)中…為氫原子之通式（8_丨）[式 中’G、Ym、lAn表示與上述者相同之意義] 表示之化合物與通式（48)[式中，^表示氧原子或硫原子] 表示之市售光氣、硫代光氣或彼等之對等物，依照文獻記 載之Λ知方法[例如依知、Angew Chem Engl , 1987 年 26 卷，894 頁及 1995 年，34 卷 ’ 2497 頁，j 〇rg Chem , 76 年 ’ 41 卷 ’ 2070 頁，Synthesis，1988 年，99〇 頁， 1997年，38卷，919頁等]反應，可以容 易地合成通式⑽[式中，G、w]、Y、R4、R5 R6、Un 表不與上述者相同之意義]表示之化合物。 之原 料化合物 即 通 在衣ie法G中，供製造本發明化合物 式（13)表示之化合物，如下述合成。 314918 143 200407073 反應式2 2
亦即’藉由將通式（49)[式中，χ及功 同之意義]表示之化合物及通式（8)中R1 :不與上述者才 (8-1)[式中，G、丫^^叫及以氧原子之通式 之意義]表示之化合物在與製造法 ：卞與上述者相斤 或者將通式（49)表示之化合物用公知之方之條件下反應， 虱、五氣化磷或草醯氯等鹵化劑 (例士亞钬 後，與通式㈣U之化合物反應酸氯化物 03)[式中，G、x、y、r4、r5、r6、卜4易地合成通式 者相同之意義]表示之化合物。 巾及η表不與上述 其中所使用之通式（49)表示 部分可從市售品得到。 物為公知化合物’ 又’製造法G中所你用夕、g斗/ ! Μ “一， 式（14)表示之化合物之某 些為公知化合物，部分可從 〇 ^ ^ 〇 〇口侍到。除此以外者，亦 可依照文獻記載之一妒入士、士y 瓜合成方法，例如依照j 〇rg chem·， 1996 年，61 卷，3883 頁，3 929 百 b ' 頁及 6575 頁，以及 Tetrahedron 年，40卷，363頁及6121頁等記載之方法容易 3149J8 144 200407073 地合成。 製造法Η所使用之通式〇5)表示之化合物及製造法I 所使用之通式（16)表不之化合物之某些為公知化合物，部 分可從市售品獲得。又，除此以外者，亦可依照文獻記載 之一般合成方法[例如依照Chem· Lett· 1976年，373頁， J· Am· Chem· Soc·，1964 年，86 卷，4383 頁，】〇巧 ， 1976 年，41 卷，4028 頁及 1978 年，43 卷，3244 頁，〇rg· synth.，1988 年，集合本第 6 卷，1〇1 頁，Tetrahedr〇nLeu 1972年，4339頁，英國專利（GB2，161，8〇2號公報）及歐洲 專利（EP| 005 1273號公報）等記載之方法]容易地合成。 在製造法J中，供製造本發明化合物之原料化合物， 即通式（17)表不之化合物，藉由將通式（21)表示之化合物以 一般使用之方法脫保護後，用製造法A至製造法G同樣地 合成本發明化合物。 衣造法J所使用之通式（18)表示之化合物及通式（19) 表丁之化合物之某些為公知化合物，部分可從市售品獲 行又’除此以外者，各化合物亦可依照文獻記載之公知 方法[例如就通式（18)表示之化合物而言，依照Chem. Lett.， 1 9 δ 6 ，i 〇 〇 '•gp 貝 ’ J· Org. Chem” 1980 年，45 卷，3916 頁 及1990年，輿 )巷 ’ 4585 頁，Tetrahedron Lett·，1993 年， 34 卷，283 1 w 貝及1996年，37卷，5699頁等記載之方法； 就通式（1 9、矣一 、不之化合物而言，依照J. Fluorine Chem.， 1991 年，5S 主 I ’ M9 頁及 j· 〇rg· Chem·，1979 年，44 卷， 3 872頁算## 寺δ己載之方法]容易地合成。 145 314918 200407073 通式（20)表示之化合物之某些為公知化合物，部分可 從市售品獲得。又，除此以外者，例如可如下述合成。 反應式2 3 r^YC00R /^^COOR (X)m (50)
亦即，藉由將通式（50)[式中，乂及爪表示與上述者相 同之意義’以及R表示甲基及乙基等低級烷基]表示之化合 物，依照文獻記載之一般水解反應[例如依照Αη§，· Cbm. 195 1 平，6 3 329 頁及 J· Am. Chem· Soc·，1929 年 卷，1865頁等記載之方法]，做成通式（51)[式中’=上=相同之意義]表示之駄酸衍生物後，進行文獻 :載5之2:=水環：反應，例如於依…—^ 9頁寻δ己載之方法之條件下進行反應， 付到通式（20)[式中，又及 心 示之化合物。 表不铃上述者相同之意義]表 其中所使用之通式（50)表 部分可從市售品獲得。 不之化合物為公知祀合物 通式（21)表示之化合物 反應式2 4 例如可如下述合成。 314918 146 200407073
TR
NIP
4R (34) 亦即，可藉由將通式（52)[式中，Y、Rl、n&amp;p表示 兵上述者相同之意義，以及J9表示脫離基諸如溴原子、埃 原i代磺酸基（例如氟磺醯氧基）、Ci_4 _代烷磺酸基（例 士一銳甲石黃醯氧基）]表示之化合物及通式（53)[式中，r4、 及R6b表示與上述者相同之意義，以及J1G表示溴原子 及碘原子等鹵素原子]表示之化合物，用文獻記載之一般鈀 等過渡金屬催化劑進行交聯偶合反應，例如依照j. 〇%·
Chem·，1991 年，56 卷，7336 頁及 Tetrahedron Lett.，2001 年，42卷，4083頁等記載之方法進行反應，可以得到通式 (21)[式中，γ、R!、R4、R“、Ra、n &amp; p表示與上述者相 同之意義]表示之化合物。 其中所使用之通式（5 3)表示之化合物之某些為公知化 合物，部分可從市售品獲得。又，除此以外者，亦可依辟 文獻記載之公知方法[例如依照J. Am. Chem. Soc.，1971 年，93 卷，1 925 頁及 Tetrahedron lett·，1990 年，31 卷， 314918 147 200407073 1919頁等記載之方法]容易地合成。 或者，可藉由使通式（34)[式中，γ、R1、r4、n及p ^ /、 t者相同之意義]表不之化合物進行文獻記載之 公知之幾基之烯烴化反應，例如依照⑽§· η·，Η% 年 ’ 51 卷，5252 頁及 1994 年，59 卷，2898 頁，Synthesis， 洲年，29 頁及 Tetrahedron lett·，1985 年，26 卷，5579 頁等記載之方法進行反應，可以得到通式⑼表示之化合 物0 L式（22)表示之化合物，例如可如下述合成。 反應式2 5
(22) 亦即’藉由將通式（54)[式中，γ、Rl、r4、R6a、R6b η及P表示與上述者相同之音羞 ― a T u心心我j表不之化合物，依照文獻 記載之方法，例如依照j· Am· Chem s〇c，1951年，73卷， 96頁及1965年，87卷，1358百笪々被少古土 a — 貝寺§己載之方法與氨反應， 或者依照Heterocycles，1986年，24卷，931頁等記載之 方法進行醯胺化反應後予以還原，可以得到通式（22)[式 中，Y、R1 、R4、R6a、R6b、 κ 11及ρ表不與上述者相同之意 義]表示之化合物。 通式（2 7)表示之化合物例如可如下述合成。 反應式2 6 314918 148 200407073
(28-1) 亦即，藉由將通式（55)[式中，γ、 本千盥卜、+、土 4门立 R 、R4、J4、η及Ρ 表不/、上述者相同之意義]表示之化 「4中，Ρ β 了3主- Λ L 初马公知之通式（24) [式宁R及J表不與上述者相同之意義1#一 ^ 、系彳丄 , ^義]表不之化合物或 通式（25)[式中，尺5表示與上 ^ ^ . 百邳U之思義]表示之化合 物，在一反應式5同樣之條件下進^ 卞卜進仃反應，可以得到通式 (27)[式中，γ、R1、R4、R5 4 ^ n&amp;p表不與上述者相同 之意義]表示之化合物。 或者，將通式（28)中尺“及為氫原子之通式（28_υ [式中，^、^、…、…、^^及卩表示與上述者相同之意義] 表示之化合物，依照文獻§己載之公知方法，例如依照j 〇rg
Chem.，2000 年，65 卷 ’ 9223 頁，Tetrahedron lett.5 1995 年’ 36卷，1223頁及德國專利公報（DE 19528778號公報） 等記載之方法反應，可以得到通式（27)表示之化合物。 通式（28)表示之化合物例如可如下述合成。 149 314918 200407073 反應式27
(56) \ (25)
\ ^ ^ I m 亦即，藉由將通式（56u 一々, )[式中，丫、尺】、尺4、11及？表 不與上述者相同之意義〗表 r , , s π之化合物與公知之通式（24) [式中，R5及J6表示與上流土上 ν 者相同之意義]表示之化合物或 公知之通式（25)[式中，R5 ^ 表示與上述者相同之意義]表示 之化a物，在文獻記載之公 T + w 夭方法，例如依照Angew. Chem.
Int· Ed· Engl” 1996 年，主 1〇„ # , 卷，2487 頁，J.Am.Chem.Soc.， 1953 年，75 卷，5896 頁，ς u 皋，33W 百笙々 I 、 ynth· C〇mmun·，1998 年，28 巷 3317頁寻§己載之方法谁 成進仃反應，可以得到诵 中，Y、R1、R4、V、n 另 Ό 士 J 通式（28)[式 及P表示與上述者相 示之化合物。 I心義]表 通式（29)表示之化八你 口物例如可如下述合 反應式28 (Υ):
(29) 亦即，藉由將通式（54)[式中，γ、Ri η及P表示與上述者相同咅 、R a、、 相门之思義]表示之化合物，依照文獻 314918 150 200407073 記載之公知方法，例如依照Chem. Pharm· Bull·，1 993年， 41 卷，1035 頁，J· Chem· Soc·，1951 年，778 頁及 1960 年， 2 635頁等記載之方法反應，可以得到通式（29)[式中，Y、 R1、R4、R6a、R6b、n及p表示與上述者相同之意義]表示 之化合物。 通式（3 1)表示之化合物例如可如下述合成。 反應式2 9 0 0人β (57) PFh3 R5 Ο ιι C. ,PPh3 * J8· (58)
r4C ο ιι.c 、R4 (59) R4
0 O II C
C base T PPh3
(60)
、RS
亦即，藉由將公知之通式（57)[式中，R5 p .... τ 久」表不遍卜 法 二者相同之意義]表示之化合物，依照文獻記载之公知方 ’例如依照 J.〇rg· Chem 1998 年，矣 c 千，53卷，5558頁等記 314918 151 200407073 載：方法’做成通式(58)[式中，尺5及J8表示與上述者相同 之意義]表示之鱗鹽後，與公知之通式（59)[式中，Μ表一 舁上述者相同之意義]表示之化合物反應，得到通式（的） [式中，R4及R5表示與上述者相同之意義]表示之化合物， 將其依照文獻記載之公知方法，例如依照j. chd he. Perkin Trans·丨，1996年，253 1頁等記載之方法與通式 (52)9[式中，Y、R〗、n&amp;P表示與上述者相同之意義，以 及J9表示溴原子或碘原子]表示之化合物藉由鹵素-金屬交 換反應所得到之鋰鹽，可以得到通式（31)[式中，Y、、 及P表示與上述者相同之意義]表示之化合物。 又了藉由將通式（52)表示之化合物與公知之通式（6 j) [ 表示與上述者相同之意義]表示之化合物，依照 文獻。己載之公知之方法[例如依照1 989年，869 頁等圮載之方法]反應，可以得到通式（3 1)中R4為氫原子 之通式（3Μ)[式中，Y、R1、R5、η及P表示與上述者相同 之意義]表示之化合物。 通式（34)表示之化合物例如可如下述合成。 反應式3 0 152 314918 200407073
、、亦P，糟由將通式（62)[式中，γ、Rl、U p表示與 i述者/目^意義]表示之化合物與公知之通式（63)[式 中’ R表不與上述者相同之意義，以及J11表示脫離基諸 如鹵素原子、三氟曱磺醯氧基及2_吡啶氧基等]表示之化合 物’依照文獻記載之—般芳香環之醯化反應，例如依照 Chem.Lett.，199(^，78H&amp;J〇rgChem，i99^，56 卷’ '963胃#記載之方法反應，可以得到通式（34)[式中， Y R、R4、η及P表示與上述者相同之意義]表示之化合 物0 或者，可藉由將通式（52)[式中，γ、R】、^ ρ表示 與上述者相同之意a，以及J9表示漠原子或碘原子]表示 之化合物’依照文獻記載之一般方法，例如依照J. Am.
Chem.s〇c·，1955 年，77 卷，3如頁及 wr〇nLett·， _年，21卷，2129頁及1991年，32卷，·頁及美 國專利公報（US5,514,816號公報）等記載之方法，經化後， 314918 153 200407073 與公知之通式（64)[式中，r4表示與上述者相同之意義， 表不鹵素原子、羥基、金屬鹽（例如-OLi及-〇Na)、C] 4烷 ^基㈤如曱氧基及乙氧基）、u基）胺基(例如Z 安基）C〗_4 ：):兀氧基（q·4烷基）胺基（例如ο,ν—二曱基麫胺某） 或環狀胺基（例如哌咬-丨_基基、嗎福啉基基及4^甲基;底 哄-1-基基)]表示之化合物或公知之通式(59)表示之化合物 反應；或者依照Heterocycles，1987年，25卷，221頁， Synth· Commun·，1985 年，15 卷，1291 頁及 199〇 年，2〇 卷’ 1469頁及德國專利公報（DE 19727042號）等記載之方 法，於形成葛里納反應試劑後，與通式（64)表示之化合物 或通式（59)表示之化合物反應，可以得到通式（3句表示之化 合物。 通式（43)表示之化合物及通式（45)表示之化合物，可與 通式（21)表示之化合物同樣地合成。 通式（52)表示之化合物例如可如下述合成。 反應式3 1 3149)8 154 200407073
亦即，藉由將公知之通式（65)[式中，Υ、R1、n及j9 表不與上述者相同之意義]表示之取代苯胺，依照文獻記載 之叙方法’例如依照J· Med· Chem·，1996年，39卷，673 頁及1997年，40卷，3542頁等記載之方法保護胺基，可 以付到通式（52)[式中，丫、111、；9、11及1&gt;表示與上述者相 同之意義]表示之化合物。 與上述者相同之意義]表示之取代胺基紛，在同樣條件下 護胺基’做成通式(67)[式中…^…表示血上, 者相同之意義]表*之化合物後，進行文獻記載之-般於 基反應，例如依照；.〇rg.Chem，1994 3、 及，年，卷，1216頁等記載之方法 9: 或氟磺酸酐反應，可以得到j9 、虱甲石只酉文 氧基之通式⑻表示之化合物為三氟曱伽氧基或氣^ 通式(54)表示之化合物例如可如下述合成。 314918 155 200407073 反應式3 2
亦即’藉由將通式（21)[式中，Y Ri R4、R6a、R6b 表二與上述者相同之意義]表示之化合物，依照文獻 吕己戟之公知方法，例如佑昭Λ
Angew. Chem. Int. Ed. Engl 2000 年 ’ 39 卷，3473 頁，j Am c OA ’ · Am· Chem· Soc·，2001 年，123 卷: 2933頁及Synthesis，1999年，249頁等記载之方 行氧化，可以得到通式（54)[式中，γ、r1、r4、&quot;an n及P表示與上述者相同之意義]表示之化合物。 通式（55)表示之化合物例如可如下述合成。 反應式3 3 R1
(56-1)
π乳屌于之通式 (56-D[式中’ Y'mu ρ表示與上述者相同之意&quot; 表示之化合物，依照文獻記載之公知古、、:t 1 ^ Λ知万法，例如依照J.0]
Chem·，1959 年，24 卷，527 ¥，ςνη心。· 、· 只 Synthesis，1987 年，4 頁及Tetrahedron，1993年，49卷，1993頁笪々恭 只寻C載之方 314918 156 200407073 反應，可以得到通式（55)[式中，丫、尺1、尺4、了4、11及？表 示與上述者相同之意義]表示之化合物。 通式（5 6 )表示之化合物例如可如下述合成。 反應式34
亦即，藉由將通式（68)[式中，Y、R1、R4、η及P表 示與上述者相同之意義，以及R表示氫原子或者甲基及乙 基等低級烷基]表示之化合物，依照文獻記載之公知方法， 例如依照 Chem. Pharm. Bull·，1965 年，13 卷，999 頁，夂 Org· Chem·，1993年，58卷，3568頁及德國專利公報（DE 19528778號公報）等記載之方法還原，可以得到通式（56) 中1163及1161)為氫原子之通式（56-1)[式中，丫、111、114、11 及P表示與上述者相同之意義]表示之化合物。 通式（6 8)表示之化合物例如可如下述合成。 反應式3 5 157 314918 200407073
亦即’藉由將通式（34)[式中，γ、ri、r4、η及p表 不與上述者相同之意義]表示之化合物，例如依照j· Am. Chem· Soc.，196〇 年，82 卷，_ 頁及 Tetrahedr〇n :扣， 1996年，37卷，8655頁等記載之胺基酸合成方法，做成 通式(69)[式中，Y、R1、R4、…表示與上述者相同之 意義]表&gt;示之胺基腈後，依照例如；chem.s〇c，i962年，
79頁等5己載之方法水解，或者依照j Am乂‘ s 1943年m …I 年 頁及丁etrahedron : Asymmetry，1 997 卷2913頁及德國專利公報（DE 19528778號公報） 二=，做成通式(7。)[式中，Y、R1、R4、nw 到通式(:=:!，示之㈣二酮後水解， 為虱原子之通式（68-1)[式中，y、r】、r4、 、不與上述者相同之意義]表示之化合物。 314918 158 200407073 在此等之各個反應中，於反應終了後，藉由進行通常 之後處理，可以得到能形成製造法A至製造法j之原料化 合物之各個製造中間體。 〃 又，藉由此等方法製造之各個製造中間體，可在未單 離及精製下，分別用於本身之接續步驟之反應中。 早 斤本發明所包含之化合物，具體而言，例如為在第2表 至第7表中所示之化合物。但是，第2表至第7表之化人 物僅係為了例示，但本發明不限於此。 又’在表中，Et表示乙基，n-Pr及Pr-n表示正丙基， i 及P卜i表示異丙基，c-Pr及Pr-c表示環丙基，n_gu 及Bu-n表示正丁基，s_Bu及Bu-s表示第二丁基，及 Bu_i表示異丁基，t-Bu及Bu-t表示第三丁基，及Bu_c 表示環丁基，n-Pen及Pen_n表示工戊基，c-Pen及Pen-C 表示環戊基，n-Hex及Hex-n表示$己基，c_Hex及Hex-C 表示環己基，Oct表示辛基，Pll表系苯基，^Naph表示^ 萘基，2-Naph表示2-萘基。 表中T-1至T-24，各個表示下述之構造·· 159 314918 200407073
Cl
Wei
Br
F T-1: Τ -4: Τ -7: Τ-10： Τ-13: Τ-16 ： Τ -19: Τ - 22: 表
Cl
XI c T-2：—〈
Br \^Br :-7&lt; T-3: CH3 ch2sch3 T-b： —7&lt;J T-6 : ch3 CH2S(0)CH3 &gt; T—8:
ch2so2ch3 ch2sch3 C T~9 ： - J CH2OH CH2SCH3 CH2S(0)CH3 T -11: T -12: f o o o ch2so2ch3 o T-14： T-17 CF, sch3
T-15 '〇 ch3 T-18：
T- 20 : —N Ο T-21 ： —N S —V T_23:飞‘ CF3 -CHi T-24 : —/—CF3 N—0 中L-la至L-55a表示之芳香族雜環，各表示下述之 160 314938 200407073 構造： L-la : L-ld ： L-lg ： L - 2a : L - 3b : z L-3e : L-3h - L-3k： 卜比:卜1c L-le：-O^CF, L~lf so2ch3 L_lh:/^N〇2 L-仏 L~2b
Br L - 3a :
、S L-3C:，SXC1 L， L - 3f ··
S^cF3 L - 3g
s
Cl
S L-3j : L~3m - S〇2CH3 200407073 L-4b：
Cl
Br NO, / 2 Wc : L-4d : L-4e：
L 一 5a: L - 5b:
F ΐ L 一 6a :
CK3 Br CH3 N〇2 N-. L-6b: L· \ L~6c：.
CH3
CH3 L - 6d:
Br L - 8a
N
Br L-lOa ： /sch3 L-lOd ： o L 一 10b ·· L-lOc : L-Ub ： L-Ue ：
Ν=λ L - 14d N： L - 14a : ^
N
CF, N： L^Uf : l-Us：
L-:Uh :
L一16a : &gt;、c秘rL—16b: chf2 162 314918 200407073 ci
L-17a ： Ji N &quot;V ch3 L-21a :
s
L - 20a
O
L-21c : ，-Br L-21d ：
L_21e
CT3
L-2H : 广N〇2 O L-22a ：
L-22b ： L - 22c L-22d
SCH3 L-23a
〇 L-23b：
λλ1 &quot; vv L^3e: /-SCH3
λ L-23d ·· /^ 入n〇2 S
L-23c： &gt;-Br S CH3 C\\ L-23h：^S^SCH3
L-23f·· 乂 'Cl S 〇
XjtTAs, ••力
1-7M l-U\&gt;: L一24e ··
lr24c: /N^Br
N〇2 314918 163 200407073 CH3 L 一 25a: L~25b ： CH3 Ni CH3 L-25d ：
cf3 Cl L-31a :
N—N 、0
Cl ---- L-25c L - 25e L - 31b
N—N ch3 L - 30a L - 31c
N： L 一 34a: L-36b ： L-36e ： L—3&amp;a : 乂 Ph L-36a ： ^ ^ F Cl &lt; ^={ L-36c ·· L~36d N02 ch3 N—N ch3 N- L - 38a:^^ci L-38b
Br
Br CH3 L-38c :
N—N N02 W5a：
L一45b :
4
Cl I L 一45c L-45f
r^r-C1 L-45d ： J| N L-45e ：
Br L 一 45g:
CF3 L-45h
N〇2 164 314918 200407073
L一45© : L -46c ·· ^Br ：J〇f L~m： L^46e : W6h :
L^46i : L-461 ： :ifVV% CF3
l-47b: fiN L-47a
200407073
ci I
N L-47e 八PT0
L-48a : || I
Br N. N…Cl L一48b : L-50c ： L一50f : L 一 50a: L - 50d: • N、/S02CH3 L一51a : L一50b : N·
IT L-50e ： -N SCH3.Cl L-51b ：
N ,SCH, N〆^丨〆0 L一51c : I丨 I L—53a :
N I N L-55a ： ^ 、N·
；N 再者，表中M-4a至M-22a表示之脂肪族雜環，各表 示下述之構造： Ϊ 一 5a: M-4a：
M-8a：
S Ϊ - 9a: O〇 Ha: 〇3 ch3 o M-9b: —/^Ί Ϊ 一 9c: ^S02 Ϊ一16a :
Ο Ϊ一19a :
S M-22a：
N—C Ο OEt 166 314918 200407073 下述第2表中，以通式[1]-22表示之化合物中，不存 在對應於表中R2之取代基。 第2表
314918 200407073
168 314918 200407073
R5 5r 3 F c
、o R5 14 ] R4
[1] - 16
169 314918 200407073
170 314918 200407073
-4
0
R5 [l]-28 5r
R5 4 ΤΊ
R5 9 2 - 1 1 [ 1J IX [ o 3 171 314918 200407073
R5 [1]-31
R5 [l]-32 c
R5 4
R5 3 3 I u 1 n
34 I 1J
R5
4 P
R5 [l]-35 7 [l]-36 9 172 314918 200407073
c
R5
5r 9 3 I 1J 1 [
0 4 1 1 1 r-L
5r -4
R5 [l]-42 173 314918 200407073
R5
5r 43 1 1 [
TJ 4 4 c
R5
[l]-46 45 * r----- ^ 1 n
5r
R5 [1] -47 [l]-48 174 314918 200407073
175 314918 200407073
5r 5rr5 [ij-59 ， [l]-60 176 314918 200407073 134
R5
Br
61 1 ί 1 η [1卜62
R5
3 6 I TJ 1 [ [1]·64 -4
R5
5 6 - u 1 ruL
[1]-66 177 314918 200407073
R5 7 6 • u 1 [
R5 9 6 - 1J X [ 4r
R5
1 I u 1 [
178 314918 200407073
5r
73 - u 1X rL
R5
5r JO I TJ 1 n 4r
R5
5r
77 • 1J 1 rL
87 I TJ ]79 314918 200407073
5r
[1]- 80 [l]-79
H ch3 ch3 cf3 Ph-4-F H ch3 ch3 cf3 Ph-4-Cl H ch3 ch3 cf3 Ph-4-Br H ch3 ch3 cf3 Ph-4-I H ch3 ch3 cf3 Ph-4-CF3 H ch3 ch3 cf3 Ph-4~0CHF2 H ch3 ch3 cf3 Ph-4-0CF3 H ch3 ch3 cf3 Ph-4-0CF2Br H ch3 ch3 cf3 Ph-4-0CF2CHF2 H ch3 ch3 cf3 Ph-4-0CF2CHFCl H ch3 ch3 cf3 Pb-4-0CF2CHFCF3 H ch3 ch3 cf3 Ph-4-0CF2CHF0CF3 H ch3 ch3 cf3 Ph-4-0CF2CHF0CF2CF2CF3 180 314918 200407073
Η ch3 ch3 cf3 Ph-4-0S02CH Η ch3 ch3 cf3 Ph+SCH3 Η ch3 ch3 cf3 Ph-4-S (0) CH； Η ch3 ch3 cf3 Ph-4-S02CH3 Η ch3 ch3 cf3 Ph-4-NO2 Η ch3 ch3 cf3 Ph-4-CN Η ch3 ch3 cf3 Ph~4~C (0) NH； Η ch3 ch3 cf3 Ph-4-C (S) NH； Η ch3 ch3 cf3 Ph-3, 4-Cl2 Η ch3 ch3 cf3 L - 46d Η ch3 ch3 cf3 L - 46e Η ch3 ch3 cf3 L-46f Η ch3 ch3 cf3 L-46g Η ch3 ch3 cf3 L-46j Η ch3 ch3 cf3 L-46k Η ch3 ch3 cf3 L-46r Η ch3 ch3 Ph-4-F ch3 Η ch3 ch3 Ph-4-C1 ch3 Η ch3 ch3 Ph_4-Br ch3 Η ch3 ch3 Ph-4-I ch3 Η ch3 ch3 Ph+CF3 ch3 Η ch3 ch3 Ph-4-0CHF2 ch3 Η ch3 ch3 Ph-4-0CF3 ch3 Η ch3 ch3 Ph-4-0CF2Br ch3 Η ch3 ch3 Ph-4-0CF2CHF2 ch3 Η ch3 ch3 Ph-4-0CF2CHFCl ch3 Η ch3 ch3 Ph-4-0CF2CHFCF3 ch3 Η ch3 ch3 Ph-4-0CF2CHF0CF3 ch3 Η ch3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 ch3 Η ch3 ch3 Ph-4-CN ch3 Η ch3 ch3 Ph-3,4-Cl ch3 ch3 ch3 ch3 cf3 Ph+SCH3 ch3 ch3 ch3 cf3 Ph+S (0) CH: ch3 ch3 ch3 cf3 Ph+S02CH3 ch3 ch3 ch3 Ph-4-Cl ch3 ch3 ch3 ch3 Ph-4-0CF3 ch3 H Et ch3 ch3 Ph-4-F
181 3)4918 200407073 Η Et ch3 Et Ph-4-S02CH3 Η Et ch3 n-Pr L - 46d Η Et ch3 i-Pr Ph-4-F Η Et ch3 chf2 Ph-4-S02CH3 Η Et ch3 cf3 Cl Η Et ch3 cf3 ch3 Η Et ch3 cf3 〇ch3 Η Et ch3 cf3 sch3 Η Et ch3 cf3 N(CH3)2 Η Et ch3 cf3 Ph_4_F Η Et ch3 cf3 Ph-4-Cl Η Et ch3 cf3 Ph-4-Br Η Et ch3 cf3 Ph-4-I Η Et ch3 cf3 Ph-4-CF3 Η Et ch3 cf3 Ph-4-0CHF2 Η Et ch3 cf3 Ph-4-OCFa Η Et ch3 cf3 Ph-4-0CF2Br Η Et ch3 cf3 Ph-4-0CF2CHF^ Η Et ch3 cf3 Ph-4-0CF2CHFCl Η Et ch3 cf3 Ph-4-0CF2CHFCF3 Η Et ch3 cf3 Ph-4_0CF2CHF0CF3 Η Et ch3 cf3 Ph-4-0CF2CHF0CF2CF2CF3 Η Et ch3 cf3 Ph-4-0S02CH3 Η Et ch3 cf3 Ph-4-SCH3 Η Et ch3 cf3 Ph+S(0)CH3 Η Et ch3 cf3 Ph-4-S02CH3 Η Et ch3 cf3 Ph-4-N02 Η Et ch3 cf3 Ph-4-CN Η Et ch3 cf3 Ph-4-C (0) NH2 Η Et ch3 cf3 Ph-4-C (S)NH2 Η Et ch3 cf3 Ph-3.4-F2 Η Et ch3 cf3 Ph-3-F-4-C1 Η Et ch3 cf3 Ph-3,4-Cl2 Η Et ch3 cf3 L-lc Η Et ch3 CFs L - 3d Η Et ch3 CF3 L-23e Η Et ch3 cf3 L-45g 182 314918 200407073 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 H Et ch3 cf3 cf3 cf3 cf3 cf3 cf3 cf2ci cf2cf3
Ph-4-F Ph-4-Cl Ph-4-Br Ph-4-I Ph-4-CF3 Ph-4-0CHF2 Ph-4-0CF3 Ph-4-0CF2Br Ph-4_0CF2CHF2 Ph-4-0CF2CHFCl Ph-4-0CF2CHFCF3 Ph-4-0CF2CHF0CF3 Ph-4-0CF2CHF0CF2CF2CF3 Ph-4-0S02CH3 Ph-4-SCH3 Ph-4-S02CH3 Ph-4-CN Ph-3, 4-F2 Ph~3~F~4_C1 Ph-3, 4-Cl2 L-lb L - lc L-le L-li L-2b L-3c L - 3d L~3f L-3k L-46d L-46g L-46j L - 46m L - 47a L-47e L-46d Ph-4-F CH3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 . ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 183 314918 200407073 Η Et ch3 L-31 ch3 Η Et ch3 L - 4b ch3 Η Et ch3 L - 4c ch3 Η Et ch3 L-45e ch3 Η Et ch3 L-45g ch3 Η Et ch3 L - 46g ch3 Η Et ch3 L - 46j ch3 Η Et ch3 L-46k ch3 Et Et ch3 cf3 Ph-4-F Et Et ch3 cf3 Ph-4-Cl Et Et ch3 cf3 Ph-4-0S02CH Et Et ch3 cf3 Ph-4-SCH3 Et Et •ch3 cf3 Ph-4-S (0) CH； Et Et ch3 cf3 Ph-4-S02CH3 Et Et ch3 cf3 Ph+N02 Et Et ch3 cf3 Ph+CN Et Et ch3 cf3 Ph-3, 4-Cl2 Et Et ch3 cf3 L-46d Et Et ch3 Ph-4-F ch3 Et Et ch3 Ph-4-Cl ch3 Et Et ch3 Ph-4-Br ch3 Et Et ch3 Ph-4-CF3 ch3 Et Et ch3 Ph-4-0CHF2 ch3 Et Et ch3 Ph_4-0CF3 ch3 Et Et ch3 Ph+0S02CH3 ch3 Et Et ch3 Ph-4-SCH3 ch3 Et Et ch3 Ph-4-S02CH3 ch3 Et Et ch3 Ph-4-CN ch3 Et Et ch3 Ph-3, 4-Cl2 ch3 H n-Pr ch3 ch3 P11-4-S02CH3 H n-Pr ch3 Et L-46d H n-Pr ch3 n-Pr Ph-4-F H n-Pr ch3 i-Pr Ph-4-S02CH3 H n-Pr ch3 chf2 L-46d H n-Pr ch3 cf3 Cl H n-Pr ch3 cf3 ch3 H n~Pr ch3 cf3 〇CH3 184 314918 200407073 Η η-Ργ ch3 cf3 sch3 Η π-Ργ ch3 cf3 N(CH3) 2 Η n-Pr ch3 cf3 Ph-4-F Η n-Pr ch3 cf3 Ph-4-Cl Η n-Pr ch3 cf3 Ph-4-Br Η n-Pr ch3 cf3 Ph-4-0CF3 Η n-Pr ch3 cf3 Ph-4-0S02CH Η n-Pr ch3 cf3 Ph-4-SCH3 Η n-Pr ch3 cf3 Ph-4-S (0) CH； Η n-Pr ch3 cf3 Ph-4-S02CH3 Η n-Pr ch3 cf3 Ph-4-N02 Η n-Pr ch3 cf3 Ph-4-CN Η n-Pr ch3 cf3 Ph-4-C (0)NH； Η n-Pr ch3 cf3 Ph-4-C (S) NH； Η n-Pr ch3 cf3 Ph-3,4-Cl2 Η n-Pr ch3 cf3 L - 46d Η n-Pr ch3 cf3 L - 47a Η n-Pr ch3 cf3 L - 47e Η n-Pr ch3 cf2ci Ph-4~F Η n-Pr ch3 cf2cf3 Ph-4-S02CH3 Η n-Pr ch3 Ph-4-F ch3 Η n-Pr ch3 Ph-4-Cl ch3 Η n-Pr ch3 Ph-4-Br ch3 Η n-Pr ch3 Ph-4-CF3 ch3 Η n-Pr ch3 Ph-4-0CHF2 ch3 Η n-Pr ch3 Ph-4-0CF3 ch3 Η n-Pr ch3 Ph-4-0CF2Br ch3 Η n-Pr ch3 Ph-4-0CF2CHF2 ch3 Η n-Pr ch3 Ph~4-0CF2CHFC1 ch3 Η n-Pr ch3 Ph-4-0CF2CHFCF3 ch3 Η n-Pr ch3 Ph-4-0CF2CHF0CF3CH3 Η n-Pr ch3 Ph-4-0S02CH3 ch3 Η n-Pr ch3 Ph+SCH3 ch3 Η n-Pr ch3 Ph-4-S02CH3 ch3 Η n-Pr ch3 Ph-4-CN ch3 Η n-Pr ch3 Ph-3, 4-F2 ch3 Η n-Pr ch3 Ph-3_F-4~C1 ch3 ]85 314918 200407073 H n-Pr Η n-Pr Η n-Pr Η n-Pr CH3 n-Pr CH3 n-Pr CH3 n-Pr CH3 n-Pr CH3 n-Pr CH3 n-Pr Et n-Pr Et n-Pr n-Prn-Pr n-Prn-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr
CH3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 H H H H H H H H H H H H F F F F F F F F F F F
Ph-3, 4-Cl2 ch3 L-3c ch3 L - 3k ch3 L-4b ch3 cf3 P1i+SCH3 cf3 Ph-4-S (0) CH cf3 Ph-4-S02CH3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 Ph+S02CH3 ch3 cf3 Ph-4-F Ph-4-0CF3 ch3 cf3 Ph-4-S02CH3 Ph-4-0CF3 ch3 cf3 ch3 cf3 Ph-4-F cf3 Ph-4-C1 cf3 Ph-4-0S02CH cf3 Ph-4-SCH3 cf3 Ph-4-S (0) CH； cf3 Ph+S02CH3 cf3 Ph-4-CN cf3 L-46d Ph-4-F ch3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 cf3 Cl cf3 ch3 cf3 〇ch3 cf3 sch3 cf3 n(ch3)2 cf3 Ph-4-F cf3 Ph+Cl cf3 Ph+0S02CH cf3 Ph+SC.H3 CF3 Ph-4-S (0)CH, cf3 PtH - S02CH3
186 314918 200407073 i - Pr F cf3 Ph-4-CN i - Ργ F cf3 L - 22c i-Pr F cf3 卜23e i-Pr F cf3 L-46d i - Pr F cf3 L-46in i-Pr F PIi-4-Cl ch3 i-Pr F Ph-4-0CF3 ch3 i-Pr Cl ch3 L-47a i-Pr Cl Et Ph-4-F i-Pr Cl n-Pr Ph-4-S02CH3 i-Pr Cl i-Pr L-46d i-Pr Cl chf2 Ph-4_F i-Pr Cl cf3 Cl i-Pr Cl cf3 ch3 i-Pr Cl cf3 och3 i-Pr Cl cf3 sch3 i-Pr Cl cf3 n(ch3)2 i-Pr Cl cf3 Ph-4~F i-Pr Cl cf3 Ph-4-Cl i-Pr Cl cf3 Ph-4-0S02CH3 i-Pr Cl cf3 Ph-4-SCH3 i-Pr Cl cf3 Ph-4-S (0) CH3 i-Pr Cl cf3 Ph-4-S02CH3 i-Pr Cl cf3 Ph-4-NO2 i-Pr Cl cf3 Ph-4-CN i-Pr Cl cf3 Ph-4-C(0)NH2 i - Pr Cl cf3 Ph_4-C(S)NH2 i-Pr Cl cf3 L-lc i-Pr Cl cf3 L_3d i-Pr Cl cf3 L，22c i-Pr Cl cf3 L - 23e i-Pr Cl cf3 L-36a i-Pr Cl cf3 L - 45a i-Pr Cl cf3 L-45d i-Pr Cl cf3 L-45e i-Pr Cl cf3 L - 45g i-Pr Cl cf3 L-45m 187 314918 200407073 H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i&gt;Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl H i-Pr Cl cf3 L - 46d cf3 L - 46e cf3 L-46f cf3 L - 46g cf3 L-46j cf3 L - 46k cf3 L - 46m cf3 L-46r cf3 L - 47a cf3 L - 47e cf2ci Ph+S02CH cf2cf3 L-46d Ph-4-F ch3 Ph-4-Cl ch3 Ph-4-Br ch3 Ph-4-1 ch3 Ph-4-CF3 ch3 Ph-4-0CHF2 ch3 Ph-4_0CF3 ch3 Ph-4-0CF2Br ch3 Ph-4-0CF2CHF2 ch3 Ph-4_0CF2CHFC1 ch3 Ph-4-0CF2CHFCF3 CH3 Ph-4-0CF2CHF0CF3CH3 Ph-4-0S02CH3 ch3 Ph-4-SCH3 ch3 Ph-4-S02CH3 ch3 Ph-4-CN ch3 Ph-3, 4-F2 ch3 Ph-3**F-4-Cl ch3 Ph-3,4-Cl2 ch3 L - lc ch3 L-le ch3 L-li ch3 L-2b ch3 L-3c ch3 L-3d ch3
188 314918 200407073 Η i-Pr Cl L - 3ί ch3 Η i-Pr Cl L - 3k ch3 Η i-Pr Cl L-31 ch3 Η i-Pr Cl L - 4b ch3 Η i-Pr Cl L-4c ch3 Η i-Pr Cl L-45e ch3 Η i-Pr Cl L - 45g ch3 Η i-Pr Cl L-46e ch3 Η i-Pr Cl L-46g ch3 Η i-Pr Cl L-46j ch3 Η i-Pr Cl L-46k ch3 Η i-Pr Br cf3 Cl Η i-Pr Br cf3 ch3 Η i-Pr Br cf3 och3 Η i-Pr Br cf3 sch3 Η i-Pr Br cf3 N(CH3)2 Η i-Pr Br cf3 Ph-4~F Η i-Pr Br cf3 Ph-4-C1 . Η i-Pr Br cf3 Ph-4-0S02CH3 Η i-Pr Br cf3 Ph-4-SCH3 Η i-Pr Br cf3 Ph+S(0)CH3 Η i-Pr Br cf3 Ph_4-S〇2 CH3 Η i-Pr Br cf3 Ph-4-N02 Η i-Pr Br cf3 Ph_4-CM Η i-Pr Br cf3 Ph-4-C (0) NH2 Η i-Pr Br cf3 Ph-4-C (S) NH2 Η i-Pr Br cf3 L - 22c Η i-Pr Br cf3 L-23e Η i-Pr Br cf3 L - 46d Η i-Pr Br cf3 L~46m Η i-Pr Br cf3 L-47a Η i-Pr Br Ph-4-F ch3 Η i - Pr Br Ph+Cl ch3 Η i-Pr Br Ph-4-Br ch3 Η i-Pr Br Ph-4-CF3 ch3 Η i-Pr Br Ph-4-0CHF2 ch3 Η i-Pr Br Ph-4-0CF3 ch3 189 314918 200407073 Η 卜Ργ Br Ph-4-0CF2Br ch3 Η ι-Ργ Br Ph-4-0CF2CHF2 ch3 Η i-Pr Br Ph-4-0CF2CHFCl ch3 Η i - Pr Br Ph-4-0CF2CHFCF, 1 CH3 Η i-Pr Br Ph-4-0CF2CHF0CF3CH3 Η i-Pr I cf3 Ph-4-F Η i - Pr I cf3 Ph-4-Cl Η i-Pr I cf3 Ph-4-0S02CH3 Η i - Pr I cf3 Ph-4-SCH3 Η i-Pr I cf3 Ph-4-S02CH3 Η i-Pr I cf3 Ph-4-CN Η i-Pr I cf3 L-46d Η i-Pr I Ph-4-Cl ch3 Η i-Pr I Ph-4~0CF3 ch3 Η i-Pr ch3 H Ph_4-F Η i-Pr ch3 H Ph-4-Cl Η i-Pr ch3 H Ph-4-S02CH3 Η 卜Pr ch3 ch3 ch3 . Η i - Pr ch3 ch3 cf3 Η i-Pr ch3 ch3 Ph Η i-Pr ch3 ch3 Ph_4-F Η i-Pr ch3 ch3 Ph-4-Cl Η i-Pr ch3 ch3 Ph-4-Br Η i-Pr ch3 ch3 Ph-4-I Η i-Pr ch3 ch3 Ph-4-CF3 Η i-Pr ch3 ch3 Ph-4-CH2SCH3 Η i-Pr ch3 ch3 Ph-4-CH2S02CH3 Η i-Pr ch3 ch3 Ph+CH2SCF3 Η i-Pr ch3 ch3 Ph-4-CH2S02CF3 Η i-Pr ch3 ch3 Ph-4-0CHF2 Η i-Pr ch3 ch3 Ph-4-0CF3 Η i-Pr ch3 ch3 Ph-4-0S02CH3 Η i-Pr ch3 ch3 Ph-4-SCH3 Η i-Pr ch3 ch3 Ph-4-S (0) CH3 Η i-Pr ch3 ch3 Ph~4-S02CH3 Η i-Pr ch3 ch3 Ph-4-SEt Η i-Pr ch3 ch3 Ph-4-S (0)Et 190 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H 卜 Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
ch3 Ph-4-S02Et ch3 Ph-4-SPr-n ch3 Ph - 4-S(0)Pr - n ch3 Ph-4-S02Pr-n ch3 Ph+SPr-i ch3 Ph-4-S (O)Pr-i ch3 Ph-4-S02Pr-i ch3 Ph-4-SCHF2 ch3 Ph-4_S(0)CHF2 ch3 Ph-4-S02CHF2 ch3 Ph-4-SCF3 ch3 Ph-4-S(0)CF3 ch3 Ph-4_S02CF3 ch3 Ph-4-SCF2Cl ch3 Ph-4-S (0) CF2C1 ch3 Ph-4-S02CF2Cl ch3 Ph+SCF2Br ch3 Ph-4-S(0) CF2Br ch3 Ph-4-S02CF2Br ch3 Ph+N02 ch3 Ph-4-CN ch3 Ph-4-C (0) NH2 ch3 Ph-4-C (S) NH2 ch3 Ph-3, 4-F2 ch3 Ph-3-F_4-Cl ch3 Ph-3_F-4-CF3 ch3 Ph-3, 4-Cl2 ch3 Ph-3-Cl-4-0CF3 ch3 2-Naph ch3 L-lb ch3 L-lf ch3 L - lg ch3 L-2b ch3 L - 3c ch3 L~3h ch3 L-3i ch3 L-3j 191 314918 200407073 卜Pr ch3 ch3 L-3k i-Pr ch3 ch3 L~3m i-Pr ch3 ch3 L-3n i-Pr ch3 ch3 L - 4b i-Pr ch3 ch3 L-lOb i-Pr ch3 ch3 L- lOd i-Pr ch3 ch3 L-14b i-Pr ch3 ch3 L - Mi i-Pr ch3 ch3 L_14h i-Pr ch3 ch3 L_17a i-Pr ch3 ch3 L-21b i-Pr ch3 CHa L - 22b i-Pr ch3 ch3 L-22c i-Pr ch3 ch3 L-22d i-Pr ch3 ch3 L - 23b i-Pr ch3 ch3 L-23e i-Pr ch3 ch3 L - 23i i-Pr ch3 ch3 L - 23h i-Pr ch3 ch3 L - 24a i-Pr ch3 ch3 L - 24b i-Pr ch3 ch3 L~3 la i-Pr ch3 ch3 L - 31c i-Pr ch3 ch3 L - 36a i-Pr ch3 ch3 L-36c i-Pr ch3 ch3 L-45d i-Pr ch3 ch3 L - 45e i-Pr ch3 ch3 L - 45g i-Pr ch3 ch3 L - 46d i-Pr ch3 ch3 L_46e i-Pr ch3 ch3 L - 46g i-Pr ch3 ch3 L-46m i-Pr ch3 ch3 L - 46n i-Pr ch3 ch3 L - 47a i-Pr ch3 ch3 L-47e i-Pr ch3 ch3 L - 48b i-Pr ch3 ch3 L-50b i-Pr ch3 ch3 L-50e 192 314918 200407073 Η i - Ργ ch3 ch3 L - 50i Η i-Pr ch3 ch3 L-51b Η i-Pr ch3 ch3 L - 51c Η i-Pr ch3 ch3 L-53a Η i-Pr ch3 Et Cl Η i-Pr ch3 Et ch3 Η i-Pr ch3 Et cf3 Η i-Pr ch3 Et och3 Η i-Pr ch3 Et sch3 Η i-Pr ch3 Et N(CH3)2 Η i-Pr ch3 Et Ph-4-F Η i-Pr ch3 Et Ph-4-Cl Η i-Pr ch3 Et Ph-4-Br Η i-Pr ch3 Et Ph-4-I Η i-Pr ch3 Et Ph-4-CF3 Η i_Pr ch3 Et Ph-4-CH2SCH3 Η i-Pr ch3 Et Ph-4-CH2S02CH Η i-Pr ch3 Et Ph-4-CH2SCFa Η i-Pr ch3 Et Ph-4-CH2S02CF Η i-Pr ch3 Et Ph-4-0CHF2 Η i-Pr ch3 Et Ph-4-0CF3 Η i-Pr ch3 Et Ph-4-0S02CH3 Η i-Pr ch3 Et Ph-4-SCH3 Η i-Pr ch3 Et Ph-4-S (0) CH3 Η i-Pr ch3 Et Ph-4-S02CH3 Η i-Pr ch3 Et Ph-4_SEt Η i-Pr ch3 Et Ph-4-S (0)Et Η i-Pr ch3 Et Ph_4_S02Et Η i-Pr CHa Et Ph-4-SPr-n Η i-Pr ch3 Et Ph-4 - S(0)Pr-n Η i~Pr CHa Et Ph-4-S02Pr-n Η i - Pr ch3 Et Ph+SPr-i Η i-Pr ch3 Et Ph-4-S (O)Pr-i Η i-Pr ch3 Et Ph-4-S02Pr-i Η i-Pr ch3 Et Ph-4-SCHF2 Η i-Pr ch3 Et Ph-4-S(0) CHF2 Η i-Pr ch3 Et Ph-4-S02CHF2
193 314918 200407073 Η i - Pr ch3 Et Ph-4-SCF3 Η i-Pr ch3 Et Ph-4-S (0) CF3 Η i-Pr ch3 Et Ph-4-S02CF3 Η i-Pr ch3 Et Ph-4-SCF2Cl Η i-Pr ch3 Et Ph-4-S (0) CF2C1 Η i-Pr ch3 Et Ph-4-S02CF2Cl Η i-Pr ch3 Et Ph-4-SCF2Br Η i-Pr ch3 Et Ph-4-S (0) CF2Br Η i-Pr ch3 Et Ph-4_S〇2CF2Br Η i-Pr ch3 Et Ph-4-N02 Η i-Pr ch3 Et Ph-4-CN Η i-Pr ch3 Et Ph-4-C(0)NH2 Η i - Pr ch3 Et Ph-4-C ⑸ NH2 Η i-Pr ch3 Et Ph-3, 4-F, Η i-Pr ch3 Et Ph-3-F-4-Cl Η i-Pr ch3 Et Ph-3_F-4-CF3 Η i-Pr ch3 Et Ph-3, 4-Cl2 Η i-Pr ch3 Et Ph-3-Cl-4~0CF3 Η i-Pr ch3 Et L-lc Η i-Pr ch3 Et L_lg Η i-Pr ch3 Et L - 3d Η i-Pr ch3 Et L-3i Η i-Pr ch3 Et L-31 Η i-Pr ch3 Et L-3n Η i-Pr ch3 Et L-4c Η i-Pr ch3 Et L-lOc Η i-Pr ch3 Et L-14c Η i_Pr ch3 Et L-14h Η i-Pr ch3 Et L - 17a Η i-Pr ch3 Et L~2 lc Η i-Pr ch3 Et L - 22c Η i-Pr ch3 Et L - 23c Η i_Pr ch3 Et L-23e Η i-Pr ch3 Et L - 24c Η i-Pr ch3 Et L - 31b Η i-Pr ch3 Et L - 36c Η i-Pr ch3 Et L-36d 194 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
Et L-45d Et L-45e Et L-45g Et L-46d Et L-46e Et L-46g Et L - 46m Et L-46n Et L-47a Et L-47e Et L-50c Et L-50e Et L-51b Et L-53a n-Pr Cl n-Pr ch3 n-Pr cf3 n-Pr och3 n-Pr sch3 n-Pr N(CH3) 2 n-Pr Ph~4~F n-Pr Ph-4-Cl n-Pr Ph-4-0S02CH n-Pr Ph-4-SCH3 n-Pr Ph-4-S02CH3 n-Pr Ph-4-CN n-Pr L-46d i-Pr Cl i-Pr ch3 i-Pr Et i-Pr i-Pr i_Pr c-Pr i-Pr n-Bu i-Pr cf3 i-Pr ch2ch2cf3 i-Pr CH (CH3)CF3 i-Pr ch2och3 195 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i_Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H 卜Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 i-Pr CH2SCH3 i-Pr och3 i-Pr OEt i-Pr OCH2CF3 i-Pr OCH(CF3) 2 i-Pr sch3 i_Pr SEt i-Pr SCH2CF3 i-Pr N(CH3)2 i-Pr Ph-4-F i-Pr Ph-4-C1 i-Pr Ph-4-Br i-Pr Ph-4-I i-Pr Ph-4-CF3 i-Pr Ph-4-CH2SCH3 i-Pr Ph-4-CH2S02CH3 i-Pr Ph-4-CH2SCF3 i-Pr Ph-4-CH2S02CF3 i-Pr Ph-4_0CHF2 i-Pr Ph-4-0CF3 i-Pr Ph-4-0S02CH3 i-Pr * pihi-sch3 i-Pr Ph-4-S (0) CH3 i-Pr Ph-4-S02CH3 i-Pr Ph-4-SEt i-Pr Ph-4-S (O)Et i-Pr Ph-4-S02Et i-Pr Ph-4-SPr-n i-Pr Ph-4-S (O)Pr-n i-Pr Ph-4-S02Pr-n i-Pr Ph-4-SPr-i i-Pr Ph-4-S(0)Pr-i i-Pr Ph-4-S02Pr-i i-Pr Ph-4-SCHF2 i-Pr Ph-4-S(0) CHF2 i-Pr Ph-4-S02CHF2 i-Pr Ph-4-SCF3 196 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
H i-Pr CH
H i-Pr CH
H i-Pr CH
H i-Pr CH
i-Pr Ph-4-S (0) CF3 i-Pr Ph-4-S02CF3 i-Pr Ph-4-SCF2C1 i-Pr Ph+S(0)CF2C1 i-Pr Ph-4-S02CF2C1 i-Pr Ph-4-SCF2Br i-Pr Ph-4-S (0) CF2Br i-Pr Ph-4-S02CF2Br i-Pr Ph-4-N02 i-Pr Ph-4-CN i-Pr Ph-4-C (0) NH2 i-Pr Ph-4-C(S)NH2 ' i-Pr Ph-3, 4-F2 i-Pr Ph-3_F*~4-Cl i-Pr Ph-3,4-Cl2 i-Pr He i~Pr L - lg i-Pr L~3c . i-Pr L_3i i-Pr L-3k i-Pr L - 3n i-Pr L-4b i-Pr L-lOb i-Pr L-14b i-Pr L-14f i-Pr L- 17a i-Pr L - 21b i-Pr L-22b i-Pr L-23b i-Pr L-23e i-Pr L - 24b i-Pr L-31a i-Pr L-36b i-Pr L - 36c i-Pr L-45d i-Pr L - 45g i-Pr L-46d 197 314918 200407073 卜Pr ch3 i-Pr L - 46e i-Pr ch3 i-Pr L-46m i-Pr ch3 i-Pr L - 46n i-Pr ch3 i-Pr L - 47a i-Pr ch3 i-Pr L-47e i-Pr ch3 i-Pr L-50b i-Pr ch3 i-Pr L-50f i-Pr ch3 i-Pr L-51b i-Pr ch3 i-Pr L-53a i-Pr ch3 c-Pr Cl i-Pr ch3 c - Pr ch3 i-Pr ch3 c - Pr cf3 i-Pr ch3 c-Pr och3 i-Pr ch3 c-Pr sch3 i-Pr ch3 c-Pr N(CH3)2 i-Pr ch3 c-Pr Ph-4-F i-Pr ch3 c-Pr Ph+Cl i-Pr ch3 c-Pr Ph-4-0S02CH i-Pr ch3 c_Pr Ph-4-SCH3 i-Pr ch3 c-Pr Ph-4-S02CH3 i-Pr ch3 c-Pr Ph-4-CN i-Pr ch3 c-Pr Ph-3,4-Cl2 i-Pr ch3 c-Pr L-46d i-Pr ch3 n-Bu Cl i-Pr ch3 n-Bu ch3 i-Pr ch3 n-Bu cf3 i-Pr ch3 n-Bu och3 i-Pr ch3 n-Bu sch3 i-Pr ch3 n-Bu N(CH3)2 i-Pr ch3 n-Bu Ph-4-F i-Pr ch3 n-Bu Ph-4-Cl i-Pr ch3 n-Bu Ph-4-0S02CH i-Pr ch3 n-Bu Ph-4-SCH3 i-Pr ch3 n-Bu Ph-4-S02CH3 i-Pr ch3 n-Bu Ph-4-CN i-Pr ch3 n-Bu L - 46d i-Pr ch3 s-Bu ch3
198 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
s~Bu Ph-4-F s-Bu Ph-4-Cl i-Bu ch3 i-Bu Ph-4-Cl i-Bu Ph-4_S02CH3 c-Bu ch3 c-Bu Ph-4-Cl c-Bu L-46d n-Pen ch3 n-Pen Ph_4~F n - Pen Ph-4-C1 c-Pen ch3 ‘ c-Pen Ph-4-Cl c-Pen Ph-4-S02CH3 n-Hex ch3 n - Hex Ph-4-Cl n - Hex L - 46d c - Hex CH3 . c-Hex Ph-4-F c-Hex Ph-4-C1 CH2F Ph-4-Cl ch2f Ph-4-S02CH3 ch2ci Ph-4-Cl ch2ci L - 46d CH2Br Ph-4-F CH2Br Ph-4-Cl chf2 ch3 chf2 Ph-4-F chf2 Ph-4-Cl chf2 Ph-4-Br chf2 Ph-4-I chf2 Ph-4-CF3 chf2 Ph-4-CH2SCH3 chf2 Ph-4-CH2S02CH3 chf2 Ph-4-CH2SCF3 chf2 Ph-4-CH2S02CF3 chf2 Ph-4-0C:HF2 199 314918 200407073 H i_Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
chf2 Ph-4-0CF3 chf2 Ph~4~OS〇2CH3 chf2 Ph-4-0S02CF3 chf2 Ph-4-SCH3 chf2 Ph-4-S (0) CH3 chf2 Ph-4-S02CH3 chf2 Ph-4-SEt chf2 Ph-4-S (0)Et chf2 Ph-4-S〇2Et chf2 Ph-4-SPr-n chf2 Ph+S(0)Pr-n chf2 Ph-4-S02Pr-n chf2 Ph-4-SPr-i chf2 Ph-4-S (O)Pr-i chf2 Ph-4-S02Pr-i chf2 Ph+SCHF2 chf2 Ph-4-S (0) CHF2 chf2 Ph~4-S02CHFZ chf2 Ph-4-SCF3 chf2 Ph-4-S (0) CF3 chf2 Ph-4-S02CF3 chf2 Ph-4-SCF2C1 chf2 Ph-4-S (0) CF2C1 chf2 Ph-4-S02CF2Cl chf2 Ph-4-SCF2Br chf2 Ph-4-S (0) CF2Br chf2 Ph-4~S〇2CF2Br chf2 Ph-4-N02 chf2 Ph-4-CN chf2 Ph - 4-C(0)NH2 chf2 Ph-4-C ⑸ NH2 chf2 Ph-3,4-F2 chf2 Ph_3-F_4-C1 chf2 Ph-3, 4-Cl2 chf2 L-lb chf2 L-lc chf2 L - Ig 200 314918 200407073 Η Η i-Pr ch3 chf2 L-3c i-Pr ch3 chf2 L - 3d i - Pr ch3 chf2 L-3i i-Pr ch3 chf2 L-3i i-Pr ch3 chf2 L - 3k i-Pr ch3 chf2 L-31 i-Pr ch3 chf2 L-3n i-Pr ch3 chf2 L-4b i-Pr ch3 chf2 L - 4c i-Pr ch3 chf2 L-lOb i-Pr ch3 chf2 L- 10c i-Pr ch3 chf2 L-14b i-Pr ch3 chf2 L-14d i-Pr ch3 chf2 L-14f i-Pr ch3 chf2 L-17a i-Pr ch3 chf2 L-21b i-Pr ch3 chf2 L - 22b i - Pr ch3 chf2 L - 22c i-Pr ch3 chf2 L-23e i-Pr ch3 chf2 L - 24b i-Pr ch3 chf2 L~31a i-Pr ch3 chf2 L-31b i-Pr ch3 chf2 L - 36c i-Pr ch3 chf2 L-36d i-Pr ch3 chf2 L-45d i-Pr ch3 chf2 L - 45e i-Pr ch3 chf2 L-45g i - Pr ch3 chf2 L - 46d i-Pr ch3 chf2 L - 46e i-Pr ch3 chf2 L-46g i-Pr ch3 chf2 L - 46m i-Pr ch3 chf2 L-46n i - Pr ch3 chf2 L - 47a i - Pr ch3 chf2 L-47e i-Pr ch3 chf2 L-50b i-Pr ch3 chf2 L_50c i-Pr ch3 chf2 L-50f 201 314918 200407073 i_Pr ch3 chf2 L - 51b i-Pr ch3 chf2 L-53a i-Pr ch3 cf3 Cl i-Pr ch3 cf3 Br i-Pr ch3 cf3 ch3 i-Pr ch3 cf3 Et i-Pr ch3 cf3 n_Pr i-Pr ch3 cf3 i-Pr i-Pr ch3 cf3 c-Pr i-Pr ch3 cf3 n-Bu i-Pr ch3 cf3 s - Bu i-Pr ch3 cf3 i-Bu i-Pr ch3 cf3 t-Bu i-Pr ch3 cf3 c-Bu i-Pr ch3 CF3 n-Pen i-Pr ch3 cf3 CH2CH2CH (CH3) i-Pr ch3 cf3 CH2CH (CH3)Et i-Pr ch3 cf3 c - Pen i-Pr ch3 cf3 n-Hex i-Pr ch3 cf3 c-Hex i-Pr ch3 cf3 CH2F i-Pr CH3 cf3 ch2ci i-Pr ch3 cf3 CH2Br i-Pr ch3 cf3 chf2 i-Pr ch3 cf3 cf3 i-Pr ch3 •cf3 cf2ci i-Pr ch3 cf3 cfci2 i-Pr ch3 cf3 . CHCICH3 i-Pr ch3 cf3 * CF2CHF2 i-Pr ch3 cf3 cf2cf3 i-Pr ch3 cf3 c(ch3)2ci i-Pr ch3 cf3 ch2ch2cf3 i-Pr ch3 cf3 CH (CH3)CF3 i-Pr ch3 cf3 T-l i-Pr ch3 cf3 T-2 i-Pr ch3 CFa T-3 i-Pr ch3 cf3 T-4 202 314918 200407073 H i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr CH3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3
CH cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 CFs cf3 T-5 ch2och3 ch2ch2och3 ch2sch3 ch2so2ch3 ch2scf3 ch2so2cf3 ch2ch2sch3 ch2ch2so2ch3 ch2ch (CH3)SCH3 CH2CH (CH3)SEt CH2CH2Ph ‘ CH (CH3)CH2Ph M - 4a M-5a 0CH3 OEt OPr-n OPr-i OBu-n OBu-i OCH2Pr-c OBu-s OBu -1 OPen-n OPen-c OHex-n OHex-c OCH2CF3 OCH (CF3) 2 OPh 0(Ph-2 - Cl) 0(Ph-3-Cl) 0(Ph-4-Cl) SCH3 so2ch3 SEt
203 314918 200407073 H i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i - Pr H i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr H i-Pr CH3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 CH3 CFa ch3 cf3 ch3 cf3 ch3 cf3 ch3
CF S02Et SPr - n S02Pr-n SPr-i S02Pr-i SBu - n S02Bu-n SPen-n S02Pen-n SPen-c S02Pen~c SHex-n S02Hex-n SHex-c SO2Hex-c SCH2CH2Br SCH2CF3 SCH2Ph S02CH2Ph SPh S (0) Ph S02Ph N(CH3) 2 N(CH3)Et N(Et) 2 T-16 T-1T T-18 M9 T - 20 T-21 C(0) CH3 C(0)Bu-1 C(0) OCH3 C(0) OEt C(0) OPr-n C(0) OPr-i 204 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 cf3 C (0) OBu-n cf3 C(0) OBu-t cf3 C(0) och2cf3 cf3 C(0) SEt cf3 C(0)N(CH3)2 cf3 CH=NOH cf3 C(CH3)=NOCH cf3 T-22 cf3 T-23 cf3 T-24 cf3 ch:c(ch3)2 cf3 C(C1)=CH2 cf3 CBr=CHBr CFa cf=cf2 cf3 CC1=CC12 cf3 C(CH3)=CHBr cf3 Ph cf3 Ph-2-F cf3 Ph_3~F cf3 Ph-4-F cf3 Ph-2-CI cf3 Ph-3-Cl cf3 Ph-4-Cl cf3 Ph-3-Br cf3 Ph-4-Br cf3 Ph-3-I cf3 Ph+I cf3 Ph-2-CH3 cf3 Ph-3-CH3 cf3 Ph-4-CH3 cf3 Ph~4~Et cf3 Ph-4-Pr-n cf3 Ph-4-Pr-i cf3 Ph-4-Bu-n cf3 Ph_4_Bu-i cf3 Ph-4~Bu*_t cf3 Ph-3-CF3 200407073 Η i-Pr ch3 cf3 Ph-4-CF3 Η i-Pr ch3 cf3 Ph-4-C (CF3)20H Η i-Pr ch3 cf3 Ph-4-CH20CH3 Η i-Pr ch3 cf3 Ph-4-CH20CH2CF3 Η i-Pr ch3 cf3 Ph-4-CH2SCH3 Η i-Pr ch3 cf3 Ph-4-CH2S(0) CH3 Η i-Pr ch3 cf3 Ph-4-CH2S02CH3 Η i-Pr ch3 cf3 Ph-4-CH2SEt Η i-Pr ch3 cf3 Ph-4-CH2S(0)Et Η i-Pr ch3 cf3 Ph-4-CH2S02Et Η i-Pr ch3 cf3 Ph-4-CH2SPr-n Η i-Pr ch3 cf3 Ph-4-CH2S02Pr:n Η i-Pr ch3 cf3 Ph-4-CH2SPr-i Η i-Pr ch3 cf3 Ph-4-CH2S02Pr-i Η i - Pr ch3 cf3 Ph-4-CH2SPr-c Η i-Pr ch3 cf3 Ph-4-CH2S02Pr-c Η i-Pr ch3 cf3 Ph-4~CH2SBu-n Η i-Pr ch3 cf3 Ph-4-CH2S02Bu~n Η i-Pr ch3 cf3 Ph-4-CH2SCF3 Η i-Pr ch3 cf3 Ph-4-CH2S(0) CF3 Η i-Pr ch3 cf3 Ph-4_CH2S02CF3 Η i - Pr ch3 cf3 Ph+CH2SCH2CF3 Η i-Pr ch3 cf3 Ph-3-0H Η i-Pr ch3 cf3 Ph-4-0H Η i-Pr ch3 cf3 Ph-2-0CH3 Η i-Pr ch3 cf3 Ph-3-0CH3 Η i-Pr ch3 cf3 Ph-4-0CH3 Η i-Pr ch3 cf3 Ph-3-0Et Η i-Pr ch3 cf3 Ph~4~0Et Η i-Pr ch3 cf3 Ph-4-0Pr-n Η i-Pr ch3 cf3 Ph-4-0Pr-i Η i-Pr ch3 cf3 Ph-4-0Bu-n Η i-Pr ch3 cf3 Ph-4-OBu-t Η i-Pr ch3 cf3 Ph-2-0CHF2 Η i-Pr ch3 cf3 Ph-3-0CHF2 Η i-Pr ch3 cf3 Ph-4-0CHF2 Η i-Pr ch3 cf3 Ph-3-0CF3
206 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
H i-Pr CH
H i-Pr CH
H i-Pr CH
H i-Pr CH
cf3 Ph-4-0CF3 cf3 Ph_3-OCFpBr cf3 Ph-4-0CF2Br cf3 Ph-4-0CH2CH2Cl cf3 Ph-4-OCH2CF3 cf3 Ph-3-0CF2CHF2 cf3 Ph-4-0CF2CHF2 cf3 Ph-3-0CF2CHFCl cf3 Ph-4-0CF2CHFCl cf3 Ph-4-0CF2CHFCF3 cf3 Ph-4-0CH2CH=CH2 cf3 Ph-4-0CH2CH=CF2 cf3 Ph-4-OCH2CF=CF2 cf3 Ph-4-0CH2CH=CC12 cf3 Ph-4-0CH2CCl=CCl cf3 Ph-2-OCH2Ph cf3 Ph - 3-OCH2Pti cf3 Ph-4-0CH2Ph . cf3 Ph-4-0S02CH3 cf3 Ph-4*OS02Et cf3 Ph-4-0S02Pr_n cf3 Ph-4-0S02Pr-i cf3 Ph-4-0S02Pr-c cf3 Ph - 4-OSO2B11 - π cf3 Ph-4-0S02CHCl2 cf3 Ph-4-0S02CF3 cf3 Ph-4-0S02CH2CF3 cf3 Ph-3-OPh cf3 Ph-4-0Ph cf3 Ph - 4-0 (L-45g) cf3 Ph-4-0 (L-451) cf3 Ph-2-SCH3 cf3 Ph-3-SCH3 cf3 Ph-4-SCH3 cf3 Ph-4~S (0) CH3 cf3 Ph-4-S02CH3 cf3 Ph-4-SEt 207 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 cf3 Ph+S_ cf3 Ph~4-S02Et cf3 Ph-4-SPr-n cf3 Ph-4-S(0)Pr-n cf3 Ph-4-S02Pr-n cf3 Ph-4-SPr-i cf3 Ph-4-S (O)Pr-i cf3 Ph-4-S02Pr-i cf3 Ph_4~SBu~n cf3 Ph~4~S (0) Bu_n cf3 Ph-4 - S02Bii-n cf3 Ph-2~SBu~t cf3 Ph_4-SBu_t cf3 Ph~4~S (0) Bu~t cf3 Ph-4 - SO2B11 -1 cf3 Ph-2-SCHF2 cf3 Ph-3-SCHF2 CFs Ph+SCH2F . cf3 Ph-4-S (0) CH2F cf3 Ph+S02CH2F cf3 Ph+SCHF2 cf3 Ph-4-S(0) CHF2 cf3 Ph-4-S02CHF2 cf3 Ph-3-SCF3 cf3 Ph-4-SCF3 cf3 Ph-4-S(0) CF3 cf3 Ph-4-S02CF3 cf3 Ph-4-SCF2Cl cf3 Ph-4-S (0) CF2C1 cf3 Ph-4-S02CF2C1 cf3 Ph-4~SCF2Br cf3 Ph-4-S(0)CF2Br cf3 Ph-4-S02CF2Br cf3 Ph-3-N02 cf3 Ph-4-N02 cf3 Ph+N(CH3) 2 CFs Ph-4-N (Et)2 208 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 cf3 Ph-4- (T-16) cf3 Ph-2-CN cf3 Ph-3-CN cf3 Ph-4-CN cf3 Ph-4-C (0) 0CH3 cf3 Ph-4-C (0) NH2 cf3 Ph-4-C (0) NHCH3 cf3 Ph-4-C (0) NHEt cf3 Ph+C(0)N(CH3) 2 cf3 Ph-4-C (S) NH2 cf3 Ph-3-Ph cf3 Ph-4-Ph cf3 Ph-4- (L-5a) cf3 Ph-4-(L- 14a) cf3 Ph-4- (L-24a) cf3 Ph-4- (L-36a) cf3 Ph-2, 3-F2 cf3 Ph-2,4-F2 . cf3 Ph-2,5-F2 cf3 Ph-2, 6-F2 cf3 Ph-3, 4-F2 cf3 Ph-3,5-F2 cf3 Ph-2-C卜4-F cf3 Ph-2_F_3_C1 cf3 Ph+CH-F cf3 Ph-2-F-4-Cl cf3 Ph-3-F-4-Cl cf3 Ph-2-F-6-C1 cf3 Ph-2,3-Cl2 cf3 Ph-2, 4-Cl2 cf3 Ph-2, 5-Cl2 cf3 Ph-2,6-Cl2 cf3 Ph-3,4-Cl2 cf3 Ph-3,5-Cl2 cf3 Ph-2-F-4-Br cf3 Ph-3-CH3-4-F cf3 Ph-2,4-(CH3) 2 209 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H 卜Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
cf3 Ph-2,6_(CH3)2 cf3 Ph-3,4一 (CH3)2 cf3 Ph-3-0CH3-4-F cf3 Ph-2-F-4-0CH3 cf3 Ph - 3-CH - 0CH3 cf3 Ph-3-Br-4_0CH3 cf3 Ph-3-CH3-4-0CH3 cf3 Ph-2-F-5-0CH3 cf3 Ph-3-F-4-0CHF2 cf3 Ph-3-Cl-4-0CHF2 cf3 Ph-3-F-4-0CF3 cf3 Ph-3-0Ph-4-F cf3 Ph-3-N02-4-F cf3 Ph-3-N02-4-Cl cf3 Ph-2-F-5-N02 cf3 Ph-3-CN-4-F cf3 Ph-2, 3, 4-F3 cf3 Ph-2, 3,5-F3 . cf3 Ph-2,3, 6-F3 cf3 Ph-2,4,5_F3 cf3 Ph-2, 4, 6_F3 cf3 Ph-3, 4,5-F3 cf3 Ph-2, 6-F2-3-Cl cf3 Ph-2, 6-F2-3-CH3 cf3 Ph-2, 3-F2+CH3 cf3 Ph_2, 3, 5, 6-F4 cf3 Ph~2, 3, 4,5,6-F5 cf3 1-Naph cf3 2-Naph cf3 L-la cf3 L-lb cf3 L-lc cf3 L-ld cf3 L-le cf3 L-li cf3 L-lg cf3 L-lh 210 314918 200407073 i-Pr ch3 cf3 L-li i-Pr ch3 cf3 L - 2a i-Pr ch3 cf3 L-2b i-Pr ch3 cf3 L-3a i-Pr ch3 cf3 L-3b i-Pr ch3 cf3 L - 3c i-Pr ch3 cf3 L - 3d i-Pr ch3 cf3 L~3e i-Pr ch3 cf3 L-3f i-Pr ch3 cf3 L-3g i-Pr ch3 cf3 L-3h i-Pr ch3 cf3 L-3i i-Pr ch3 cf3 L - 3j i-Pr ch3 cf3 L - 3k i-Pr ch3 cf3 L-31 i-Pr ch3 cf3 L~3m i-Pr ch3 cf3 L-3n i-Pr ch3 cf3 L-3o i-Pr ch3 cf3 L-4a i-Pr ch3 cf3 L - 4b i-Pr ch3 cf3 L-4c i-Pr ch3 cf3 L - 4d i-Pr ch3 cf3 L - 4e i-Pr ch3 cf3 L - 5a i-Pr ch3 cf3 L - 5b i-Pr ch3 cf3 L-6a i-Pr ch3 cf3 L - 6b i-Pr ch3 cf3 L - 6c i-Pr ch3 cf3 L_6d i-Pr ch3 cf3 L - 6e i-Pr ch3 cf3 L - 8a i-Pr ch3 cf3 L-lOa i-Pr ch3 cf3 L - 10b i-Pr ch3 cf3 L - 10c i-Pr ch3 cf3 L- lOd i-Pr ch3 cf3 L - 11a i-Pr ch3 cf3 L-14a 211 314918 200407073 Η Η Η i-Pr ch3 cf3 L - 14b i-Pr ch3 cf3 L-14c i_Pr ch3 cf3 L-14d i-Pr ch3 cf3 L-14e i-Pr ch3 cf3 L-14f i-Pr ch3 cf3 L-14g i-Pr ch3 cf3 L-14h i-Pr ch3 cf3 L-16a i-Pr ch3 cf3 L-16b i-Pr ch3 cf3 L-17a i-Pr CH3 cf3 L - 19a i - Pr ch3 cf3 L-20a i-Pr ch3 cf3 L-21a i-Pr ch3 cf3 L-21b i-Pr ch3 cf3 L~2 lc i-Pr ch3 cf3 L-21d i-Pr ch3 cf3 L - 21e i-Pr ch3 cf3 L-21f i-Pr ch3 cf3 L-22a i-Pr ch3 cf3 L-22b i-Pr ch3 cf3 L - 22c i-Pr ch3 cf3 L - 22d i-Pr ch3 cf3 L - 23a i-Pr ch3 cf3 L-23b i-Pr ch3 cf3 L-23c i-Pr ch3 cf3 L-23d i-Pr ch3 cf3 L - 23e i-Pr ch3 cf3 L-23i i-Pr ch3 cf3 L - 23g i-Pr ch3 cf3 L - 23h i-Pr ch3 cf3 L-24a i-Pr ch3 cf3 L-24b i-Pr ch3 cf3 L-24c i-Pr ch3 cf3 L-24d i-Pr ch3 cf3 L-24e i-Pr ch3 cf3 L-24f i-Pr ch3 cf3 L-25a 212 314918 200407073 Η Η Η Η Η Η Η Η Η Η i-Pr ch3 cf3 L-25b i-Pr ch3 cf3 L-25c i-Pr ch3 cf3 L - 25d i-Pr ch3 cf3 L - 25e i-Pr ch3 cf3 L-30a i-Pr ch3 cf3 L-31a i-Pr ch3 cf3 L-31b i-Pr ch3 cf3 L-31c i-Pr ch3 cf3 L - 34a i-Pr ch3 cf3 L-35a i-Pr ch3 cf3 L - 36a i-Pr ch3 cf3 L - 36b i-Pr ch3 cf3 L - 36c i-Pr ch3 cf3 L - 36d i-Pr ch3 cf3 L~36c i-Pr ch3 cf3 L - 38a i-Pr ch3 cf3 L-38b i-Pr ch3 cf3 L~38c i-Pr ch3 cf3 L - 45a i-Pr ch3 cf3 L-45b i-Pr ch3 cf3 L-45c i - Pr ch3 cf3 L-45d i-Pr ch3 cf3 L - 45e i-Pr ch3 c‘f3 L - 45i i-Pr ch3 cf3 L - 45g i-Pr ch3 cf3 L-45h i-Pr ch3 cf3 L-45i i-Pr ch3 cf3 L-45j i-Pr ch3 cf3 L-45k i-Pr ch3 cf3 L-451 i-Pr ch3 cf3 L - 45m i-Pr ch3 cf3 L-46a i-Pr ch3 cf3 L-46b i-Pr ch3 cf3 L - 46c i-Pr ch3 cf3 L-46d i-Pr ch3 cf3 L-46e i-Pr ch3 cf3 L-46i 213 314918 200407073 i - Pr ch3 cf3 L-46g i-Pr ch3 cf3 L-46h i-Pr ch3 cf3 L - 46i i - Pr ch3 cf3 L-46j i-Pr ch3 cf3 L-46k i-Pr ch3 cf3 L-461 i-Pr ch3 cf3 L-46m i-Pr ch3 cf3 L-46n i-Pr ch3 cf3 L-46o i-Pr ch3 cf3 L - 46p i-Pr ch3 cf3 L-46q i-Pr ch3 cf3 L-46r i-Pr ch3 cf3 L - 47a i-Pr ch3 cf3 L-47b i-Pr ch3 cf3 L-47c i-Pr ch3 cf3 L - 47d i-Pr ch3 CFa L - 47e i-Pr ch3 cf3 L - 48a i-Pr ch3 cf3 L - 48b i-Pr ch3 cf3 L - 50a i-Pr ch3 cf3 L-50b i-Pr ch3 cf3 L - 50c i-Pr ch3 cf3 L-50d i-Pr ch3 cf3 L-50e i-Pr ch3 cf3 L-50f i-Pr ch3 cf3 L-51a i-Pr ch3 cf3 L-51b i-Pr ch3 cf3 L-51c i-Pr ch3 cf3 L - 53a i-Pr ch3 cf3 L - 55a i-Pr ch3 cf2ci Cl i-Pr ch3 cf2ci Br i-Pr ch3 cf2ci ch3 i-Pr ch3 cf2ci Et i-Pr ch3 cf2ci i-Pr i-Pr ch3 cf2ci c - Pr i-Pr ch3 cf2ci n-Bu 214 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
H i-Pr CHS H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
CF2C1 ch2ch2cf3 cf2ci ch(ch3)cf3 cf2ci ch2och3 cf2ci ch2sch3 cf2ci och3 cf2ci OEt cf2ci OPr-n cf2ci OPr - i cf2ci OBu-n cf2ci och2cf3 cf2ci OCH (CF3) 2 cf2ci sch3 cf2ci SEt cf2ci SPr-n CF2C! SPr-i cf2ci SBu-n cf2ci SCH2CF3 cf2ci SPh cf2ci n(ch3)2 cf2ci Ph-4-F cf2ci Ph-4-Cl cf2ci Ph+Br cf2ci Ph-4-1 cf2ci Ph-4-CF3 cf2ci Ph-4_CH2SCH3 cf2ci Ph-4-CH2S02CH cf2ci Ph-4-CH2SCF3 cf2ci Ph-4-CH2S02CF cf2ci Ph-4-0CHF2 cf2ci Ph-4-0CF 3 cf2ci Ph-4-0S02CH3 cf2ci Ph-4-SCH3 cf2ci Ph-4-S (0) CH3 cf2ci Ph-4-S02CH3 cf2ci Ph-4-SEt cf2ci Ph-4-S (O)Et cf2ci Ph-4-S02Et 215 314918 200407073 Η i-Pr ch3 cf2ci Ph-4-SPr-n Η i-Pr ch3 cf2ci Ph-4-S (O)Pr-n Η i-Pr ch3 cf2ci Ph-4-S02Pr-n Η i-Pr ch3 cf2ci Ph+SPH Η i-Pr ch3 cf2ci Ph-4-S (O)Pr-i Η i-Pr ch3 cf2ci Ph-4-S02Pr-i Η i-Pr ch3 cf2ci Ph-4-SCHF2 Η i-Pr ch3 cf2ci Ph-4-S (0) CHF2 Η i-Pr ch3 cf2ci Ph-4-S02CHF2 Η i-Pr ch3 cf2ci Ph+SCF3 Η i-Pr ch3 cf2ci Ph-4-S (0) CF3 Η i-Pr ch3 cf2ci Ph+S02CF3 ' Η i-Pr ch3 cf2ci Ph-4-SCF2Cl Η i-Pr ch3 cf2ci Ph-4-S (0) CF2C1 Η i-Pr ch3 cf2ci Ph-4-S02CF2Cl Η i-Pr ch3 cf2ci Ph-4-SCF2Br Η i-Pr ch3 cf2ci Ph-4-S (0) CF2Br Η i-Pr ch3 cf2ci Ph-4-S02CF2B.r Η i-Pr ch3 cf2ci Ph-4-N02 Η i-Pr ch3 cf2ci Ph-4-CN Η i-Pr ch3 cf2ci Ph&gt;4-C (0) NH2 Η i-Pr ch3 cf2ci Ph - 4-C(S)NH2 Η i-Pr ch3 cf2ci Ph-3, 4-F2 Η i-Pr ch3 cf2ci Ph_3-F-4-C1 Η i-Pr ch3 cf2ci Ph-3-F-4-CF 3 Η i-Pr ch3 cf2ci Ph - 3,4-Cl2 Η i-Pr ch3 cf2ci L-lb Η i-Pr ch3 cf2ci L-lg Η i-Pr ch3 cf2ci L-3b Η i-Pr ch3 cf2ci L-3c Η i-Pr ch3 cf2ci L-3i Η i-Pr ch3 cf2ci L - 3k Η i-Pr ch3 cf2ci L-3n Η i-Pr ch3 cf2ci L-4b Η i - Pr ch3 cf2ci L-lOb Η i-Pr ch3 cf2ci IH4b Η i-Pr ch3 cf2ci L - 14e 216 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i_Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 CF2C1 L - 14f cf2ci L-17a cf2ci L - 21b cf2ci L - 22b cf2ci L-23b cf2ci L-23e cf2ci L - 24b cf2ci L~31a cf2ci L-36b cf2ci L - 36c cf2ci L-45c cf2ci L-45d cf2ci L-46c cf2ci L - 46d cf2ci L_46m cf2ci L - 46n cf2ci L-47a cf2ci L-50b . cf2ci L - 50e cf2ci L - 51b cf2ci L-53a CF2Br Cl CF2Br ch3 CF2Br och3 CF2Br sch3 CF2Br N(CH3)2 CF2Br Ph-4-F CF2Br Ph-4-Cl CF2Br Ph-4-Br CF2Br Ρίι-4 -1 CF2Br Ph-4-CF3 CF2Br Ph-4-CH2SCH3 CF2Br Ph-4-CH2S02CH3 CF2Br Ph+CH2SCF3 CF2Br Ph-4-CH2S02CF3 CF2Br Ph - 4-0CHF2 CF2Br Ph-4_0CF3 217 314918 200407073 H i-Pr ch3 CF2Br Ph-4-0S02CH3 Η i-Pr ch3 CF2Br Ph-4-SCH3 Η i-Pr ch3 CF2Br Ph-4-S (0) CH3 Η i-Pr ch3 CF2Br Ph-4-S02CH3 Η i-Pr ch3 CF2Br Ph-4-SEt Η i-Pr ch3 CF2Br Ph - 4-S(0)Et Η i-Pr ch3 CF2Br Ph-4-S02Et Η i-Pr ch3 CF2Br Ph-4-SPr-n Η i-Pr ch3 CF2Br Ph - 4-S(0)Pr-n Η i-Pr ch3 CF2Br Ph-4-S02Pr-n Η i-Pr ch3 CF2Br Ph-4-SPr-i Η i-Pr ch3 CF2Br Ph-4-S(0)Pr-i ’ Η i-Pr ch3 CF2Br Ph-4-S02Pr-i Η i-Pr ch3 CF2Br Ph-4-SCHF2 Η i-Pr ch3 CF2Br Ph-4-S (0) CHF2 Η i-Pr ch3 CF2Br Ph-4~S02CHF2 Η i-Pr ch3 CF2Br Ph-4-SCF3 Η i-Pr ch3 CF2Br Ph-4-S (0) CF3. Η i-Pr ch3 CF2Br Ph-4-S02CF3 Η i-Pr ch3 CF2Br Ph-4&gt;SCF2C1 Η i-Pr ch3 CF2Br Ph-4 - S(0)CF2C1 Η i-Pr ch3 CF2Br Ph-4-S02CF2C1 Η i-Pr ch3 CF2Br Ph-4-SCF2Br Η i-Pr ch3 CF2Br Ph-4-S (0) CF2Br Η i-Pr ch3 CF2Br Ph-4-S02CF2Br Η i-Pr ch3 CF2Br Ph+N02 Η i-Pr ch3 CF2Br Ph-4-CN Η i-Pr ch3 CF2Br Ph-4-C (0) NH2 Η i-Pr ch3 CF2Br Ph-4-C (S) NH2 Η i-Pr ch3 CF2Br Ph-3, 4-F2 Η i-Pr ch3 CF2Br Ph-3_F-4-Cl Η i-Pr ch3 CF2Br Ph-3, 4-Cl2 Η i-Pr ch3 CF2Br L-46d Η i-Pr ch3 CF2Br L-47a Η i-Pr ch3 CF2CHF2 Cl Η i-Pr ch3 cf2chf2 ch3 Η i-Pr ch3 cf2chf2 och3
218 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H 卜Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
cf2chf2 sch3 cf2chf2 n(ch3)2 cf2chf2 Ph-4-F cf2chf2 Ph-4-Cl cf2chf2 Ph-4-0S02CH cf2chf2 Ph-4-SCH3 cf2chf2 Ph+S02CH3 cf2chf2 Ph-4-CN cf2chf2 Ph-3,4-Cl2 cf2chf2 L - 46d cf2chf2 L-47a cf2cf3 Cl cf2cf3 Br cf2cf3 ch3 cf2cf3 Et cf2cf3 i-Pr cf2cf3 c - Pr cf2cf3 n-Bu cf2cf3 ch2ch2cf3 cf2cf3 ch(ch3)cf3 cf2cf3 ch2och3 cf2cf3 ch2sch3 cf2cf3 〇ch3 cf2cf3 OEt cf2cf3 OPr-n cf2cf3 OPr-i cf2cf3 OBu-n cf2cf3 och2cf3 cf2cf3 OCH (CF3)2 cf2cf3 sch3 cf2cf3 SEt cf2cf3 SPr-n cf2cf3 SPr - i cf2cf3 SBu-n cf2cf3 SCH2CF3 cf2cf3 SPh cf2cf3 N(CH3)2 219 314918 200407073 Η i-Pr ch3 cf2cf3 Ph-4-F Η i-Pr ch3 cf2cf3 Ph-4-Cl Η i-Pr ch3 cf2cf3 Ph-4-I Η i-Pr ch3 cf2cf3 Ph-4-CF3 Η i-Pr ch3 cf2cf3 Ph-4-CH2SCH3 Η i-Pr ch3 cf2cf3 Ph-4-CH2S02CHc Η i-Pr ch3 cf2cf3 Ph-4-CH2SCF3 Η i-Pr ch3 cf2cf3 Ph-4-CH2S02CF3 Η i-Pr ch3 cf2cf3 Ph-4-0CHF2 Η i-Pr ch3 cf2cf3 Ph-4-0CF3 Η i-Pr ch3 cf2cf3 Ph_4_OS〇2CH3 Η i-Pr ch3 cf2cf3 Ph-4-0S02CF3 ’ Η i-Pr ch3 cf2cf3 Ph-4-SCH3 Η i-Pr ch3 cf2cf3 Ph-4-S (0) CH3 Η i~Pr ch3 cf2cf3 Ph-4-S02CH3 Η i-Pr ch3 cf2cf3 Ph_4-SEt Η i-Pr ch3 cf2cf3 Ph-4 - S(0)Et Η 卜Pr ch3 cf2cf3 Ph+S02Et . Η i-Pr ch3 cf2cf3 Ph-4-SPr-n Η i-Pr ch3 cf2cf3 Ph-4 - S (0) Pr-n Η i-Pr ch3 cf2cf3 Ph-4-S02Pr-n Η i-Pr ch3 cf2cf3 Ph-4-SPr-i Η i-Pr ch3 cf2cf3 Ph+S(0)Pr，i Η i-Pr ch3 cf2cf3 Ph-4-S0,Pr-i Η i-Pr ch3 cf2cf3 Ph+SCHF2 Η i-Pr ch3 cf2cf3 Ph-4-S (0) CHF2 Η i-Pr ch3 cf2cf3 Ph-4-S02CHF2 Η i-Pr CHs cf2cf3 Ph-4-SCF3 Η i-Pr ch3 cf2cf3 Ph-4_S (0) CF3 Η i-Pr ch3 cf2cf3 Ph-4-S02CF3 Η i-Pr ch3 cf2cf3 Ph-4-SCF2Cl Η i-Pr ch3 cf2cf3 Ph-4 - S(0)CF2C1 Η i-Pr ch3 cf2cf3 Ph-4-S02CF2C1 Η i-Pr ch3 cf2cf3 PlHhSCF2Br Η i-Pr ch3 cf2cf3 Ph-4-S (0) CF2Br Η i-Pr ch3 cf2cf3 Ph-4-S02CF2Br Η i-Pr ch3 cf2cf3 Ph+N02
220 314918 200407073 Η i-Pr ch3 cf2cf3 Ph-4-CN Η i - Ργ ch3 cf2cf3 Ph - 4-C(0)NH Η i-Pr ch3 cf2cf3 Ph-4-C (S) NH Η i-Pr ch3 cf2cf3 Ph-3, 4-F2 Η i-Pr ch3 cf2cf3 Ph+F - 4-C1 Η i-Pr ch3 cf2cf3 Ph_3-Cl-4_F Η i-Pr ch3 cf2cf3 Ph_3~F_4-CF Η i-Pr ch3 cf2cf3 Ph-3,4-Cl2 Η i-Pr ch3 cf2cf3 L-lc Η i-Pr ch3 cf2cf3 L-lg Η i-Pr ch3 cf2cf3 L-3c Η i-Pr ch3 cf2cf3 L-3d Η i-Pr ch3 cf2cf3 L-3i Η i-Pr ch3 cf2cf3 L-31 Η i-Pr ch3 cf2cf3 L - 3n Η i - Pr ch3 cf2cf3 L-4c Η i-Pr ch3 cf2cf3 L_10c Η i - Pr ch3 cf2cf3 L_14c Η i-Pr ch3 cf2cf3 L - 14f Η i-Pr CH3 cf2cf3 L - 14h Η i-Pr ch3 cf2cf3 L - 17a Η i-Pr ch3 cf2cf3 L-21c Η i-Pr ch3 cf2cf3 L-22b Η i-Pr ch3 cf2cf3 L-22c Η i-Pr ch3 cf2cf3 L~23c Η i-Pr ch3 cf2cf3 L-23e Η i-Pr ch3 cf2cf3 L-24c Η i-Pr ch3 cf2cf3 L - 31b Η i-Pr ch3 cf2cf3 L-36c Η i-Pr ch3 cf2cf3 L - 36d Η i-Pr ch3 cf2cf3 L-45d Η i-Pr ch3 cf2cf3 L - 45e Η i-Pr ch3 cf2cf3 L-45g Η i-Pr ch3 cf2cf3 L-46d Η i-Pr ch3 cf2cf3 L”46e Η i-Pr ch3 cf2cf3 L - 46g Η i-Pr ch3 cf2cf3 L-46ni 221 314918 200407073 Η i-Pr ch3 cf2cf3 L-46n Η i-Pr ch3 cf2cf3 L-47a Η i-Pr ch3 cf2cf3 L-47e Η i-Pr ch3 cf2cf3 L - 50c Η i-Pr ch3 cf2cf3 L-50e Η i-Pr ch3 cf2cf3 L-51b Η i-Pr ch3 cf2cf3 L - 53a Η i-Pr ch3 cf2cf2ci Cl Η i-Pr ch3 cf2cf2ci ch3 Η i - Pr ch3 cf2cf2ci och3 Η i-Pr ch3 cf2cf2ci sch3 Η i-Pr ch3 cf2cf2ci n(ch3)2 Η i-Pr ch3 cf2cf2ci Ph-4-F Η i-Pr ch3 cf2cf2ci Ph-4-Cl Η i-Pr ch3 cf2cf2ci Ph-4-0S02CH Η i-Pr ch3 cf2cf2ci Ph-4-SCH3 Η i - Pr ch3 cf2cf2ci Ph-4-S02CH3 Η i-Pr ch3 cf2cf2ci Ph-4-CN Η i-Pr ch3 cf2cf2ci L-46d Η i-Pr ch3 CF2CF2Br Cl Η i-Pr ch3 CF2CF2Br ch3 Η i-Pr ch3 CF2CF2Br 0CH3 Η i-Pr ch3 CF2CF2Br sch3 Η i-Pr ch3 CF2CF2Br N(CH3) 2 Η i-Pr ch3 CF2CF2Br Ph~4~F Η i-Pr ch3 CF2CF2Br Ph-4-Cl Η i-Pr ch3 CF2CF2Br Ph-4-S02CH3 Η i-Pr ch3 CF2CF2Br L - 46d Η i-Pr ch3 CFCICF3 Cl Η i-Pr ch3 CFCICF3 ch3 Η i-Pr ch3 CFC1CF3 0CH3 Η i-Pr ch3 CFC1CF3 sch3 Η i-Pr ch3 CFCICF3 N(CH3)2 Η i-Pr ch3 CFCICF3 Ph-4-F Η i-Pr ch3 CFCICF3 Ph-4-Cl Η i-Pr ch3 CFCICF3 Ph-4-S02CH3 Η i-Pr ch3 CFCICF3 L-46d 222 3)4918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i~Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
H i-Pr CHS H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
CFBrCF3 Cl CFBrCF3 ch3 CFBrCF3 och3 CFBrCF3 sch3 CFBrCF3 n(ch3)2 CFBrCF3 Ph-4-F CFBrCF3 Ph-4-Cl CFBrCF3 Ph-4-S02CH3 CFBrCF3 L_46d CFC1CF2C1 Cl cfcicf2ci ch3 cfcicf2ci 〇CH3 cfcicf2ci sch3 cfcicf2ci n(ch3)2 cfcicf2ci Ph-4~F cfcicf2ci Ph+Cl cfcicf2ci Ph-4-S02CH3 cfcicf2ci L-46d CF2CF2CF3 Cl CF2CF2CF3 ch3 cf2cf2cf3 0CH3 CF2 CF2CF3 sch3 cf2cf2cf3 N(CH3)2 cf2cf2cf3 Ph-4-F CF 2 CF2 CF 3 Ph-4-Cl cf2cf2cf3 Ph-4-0S02CH cf2cf2cf3 Ph-4-SCH3 cf2cf2cf3 Ph-4-S02CH3 cf2cf2cf3 Ph-4-CN cf2cf2cf3 卜46d CF (CF3)2 Cl CF (CF3)2 ch3 CF (CF3)2 〇CH3 CF (CF3)2 sch3 CF (CF3)2 N(CH3)2 CF (CF3)2 Ph-4-F CF (CF3) 2 Ph-4-Cl 223 314918 200407073 i-Pr ch3 i - Pr ch3 i-Pr ch3 i - Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 卜Pr ch3 i-Pr ch3 i - Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr CHs
cf(cf3)2 Ph-4-0S02CH3 CF (CF3) 2 Ph-4-SCH3 CF (CF3)2 Ph-4-S02CH3 CF (CF3) 2 Ph-4-CN CF (CF3)2 L - 46d cf2cfcicf2ci Cl cf2cfcicf2ci ch3 cf2cfcicf2ci och3 cf2cfcicf2ci sch3 cf2cfcicf2ci n(ch3)2 cf2cfcicf2ci Ph-4-Cl cf2cfcicf2ci Ph-4-S02CH3 cf2cf2cf2chf2 Cl cf2cf2cf2chf2 ch3 cf2cf2cf2chf2 och3 cf2cf2cf2chf2 sch3 cf2cf2cf2chf2 n(ch3)2 cf2cf2cf2chf2 Ph-4-Cl . cf2cf2cf2chf2 L-46d CF2CF2CF2CF3 Cl CF2CF2CF2CF3 ch3 cf2cf2cf2cf3 och3 CF2CF2CF2CF3 sch3 cf2cf2cf2cf3 N(GH3)2 cf2cf2cf2cf3 Ph_4~F cf2cf2cf2cf3 Ph-4-Cl cf2cf2cf2cf3 Ph-4-0S02CH3 cf2cf2cf2cf3 Ph-4-SCH3 CF2CF2CF2CF3 Ph+S02CH3 cf2cf2cf2cf3 Ph-4-CN cf2cf2cf2cf3 L-46d CF (CF3)CF2CF3 Cl CF (CF3)CF2CF3 ch3 CF (CF3)CF2CF3 0CH3 CF (CF3)CF2CF3 sch3 CF (CF3)CF2CF3 n(c.h3)2 CF (CF3)CF2CF3 Ph-4-F
224 3]4918 200407073 i-Pr ch3 cf2cf2cf2cf2ci Cl i-Pr ch3 cf2cf2cf2cf2ci ch3 i - Pr ch3 cf2cf2cf2cf2ci och3 i-Pr ch3 cf2cf2cf2cf2ci sch3 i-Pr ch3 cf2cf2cf2cf2ci N(CH3)2 i-Pr ch3 cf2cf2cf2cf2ci Ph+S02CH i-Pr ch3 CF2CF2CF2CF2CF2CF3 Cl i-Pr ch3 CF2CF2CF2CF2CF2CF3 ch3 i-Pr ch3 CF2CF2CF2CF2CF2CF3 och3 i-Pr ch3 cf2cf2cf2cf2cf2cf3 sch3 i-Pr ch3 CF2CF2CF2CF2CF2CF3 n(ch3)2 i-Pr ch3 cf2cf2cf2cf2cf2cf3 Ph-4-F i-Pr ch3 T-l Cl i-Pr ch3 T-1 ch3 i-Pr ch3 T-l cf3 i-Pr ch3 T-1 och3 i-Pr ch3 T-l sch3 iHPr ch3 T-1 n(ch3)2 i-Pr ch3 T-2 Cl i-Pr ch3 T-2 ch3 i-Pr ch3 T-2 cf3 i-Pr ch3 T-2 och3 i-Pr ch3 T-2 sch3 i-Pr ch3 T-2 N(CH3) 2 i-Pr ch3 T-3 Cl i-Pr ch3 T-3 ch3 i-Pr ch3 T-3 cf3 i-Pr ch3 T-3 och3 i-Pr ch3 T-3 sch3 i-Pr ch3 T-3 N(CH3) 2 i-Pr ch3 T-4 Cl i-Pr ch3 T-4 ch3 i-Pr ch3 T-4 cf3 i-Pr ch3 T-4 och3 i-Pr ch3 T-4 sch3 i-Pr ch3 T-4 Cl i-Pr ch3 T-5 CHs
225 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H 卜Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i~Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 T- 5 cf3 T-5 och3 T_5 sch3 T-5 N(CH3)2 CH20CH3 Ph-4-F ch2och3 Ph_4-Cl ch2och3 Ph-4-0S02CH ch2och3 Ph-4-SCH3 ch2och3 Ph-4-S02CH3 ch2och3 Ph-4-CN ch2och3 Ph- 3,4-Cl2 ch2och3 L-46d’ ch2och3 L-47a CH20Et ch3 CH20Et Ph-4-F CH20Et Ph-4-Cl CH20Et Ph-4-S02CH3 CH20Et L*46d CH20CH2CF3 Cl ch2och2cf3 ch3 ch2och2cf3 cf3 ch2och2cf3 och3 ch2och2cf3 sch3 ch2och2cf3 n(ch3)2 ch2och2cf3 Ph~4~F ch2och2cf3 Ph-4-Cl ch2och2cf3 Ph-4-S02CH3 ch2och2cf3 L-46d ch2och2cf2cf3 Cl ch2och2cf2cf3 ch3 ch2och2cf2cf3 cf3 ch2och2cf2cf3 〇ch3 ch2och2cf2cf3 sch3 ch2och2cf2cf3 N(CH3)2 ch2och (CF3)〇 Cl ch2och(cf3)2 ch3 ch2och(cf3)2 cf3 226 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH.3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i~Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
CH20CH (CF3) 2 och3 CH20CH (CF3)2 sch3 CH20CH(CF3)2 N(CH3)2 cf2ocf2cf2ocf3 Cl cf2ocf2cf2ocf3 ch3 cf2ocf2cf2ocf3 och3 cf2ocf2cf2ocf3 sch3 cf2ocf2cf2ocf3 N(CH3)2 cf2ocf2cf2ocf3 Ph-4-F CF (CF3)0CF2CF2CF3 Cl CF (CF3)〇CF2CF2CF3 ch3 CF (CF3)〇CF2CF2CF3 och3 CF (CF3)〇CF2CF2CF3 sch3 CF (CF3)〇CF2CF2CF3 N(CH3) 2 CF (CF3)0CF2CF2CF3 Ph-4-S02CH3 ch2sch3 Ph-4-F ch2sch3 Ph+Cl ch2sch3 Ph-4r0S02CH ch2sch3 Ph+SCH3 ch2sch3 Ph-4-S02CH3 ch2sch3 Ph-4_CN ch2sch3 Ph-3,4-Cl2 ch2sch3 L-46d ch2sch3 L-47a ch2so2ch3 Ph_4-F ch2so2ch3 Ph-4-Cl ch2so2ch3 Ph-4-S02CH3 ch2so2ch3 L-46d CH2SEt ch3 CH2SEt Ph~4_F CH2SEt Ph-4-Cl CH2SEt Ph+S02CH3 CH2SEt L-46d ch2ch2sch3 P1HK1 ch2ch2sch3 Ph-4-S02CH3 ch2scf3 Cl ch2scf3 ch3 227 314918 200407073 Η i-Pr ch3 ch2scf3 cf3 Η i-Pr ch3 ch2scf3 och3 Η i - Pr ch3 ch2scf3 sch3 Η i - Ργ ch3 ch2scf3 N(CH3)2 Η i-Pr ch3 ch2scf3 Ph_4_F Η i - Pr ch3 ch2scf3 Ph-4-Cl Η i-Pr ch3 ch2scf3 Ph-4-0S02CH3 Η i-Pr ch3 ch2scf3 Ph-4-SCH3 Η i_Pr ch3 ch2scf3 Ph-4-S02CH3 Η i-Pr ch3 ch2scf3 Ph-4-CN Η i-Pr ch3 ch2scf3 Ph-3, 4-CI2 Η i-Pr ch3 ch2scf3 L-46d Η i-Pr CH3 ch2scf3 L-47a Η i-Pr ch3 ch2ch2scf3 ch3 Η i-Pr ch3 ch2ch2scf3 Ph-4-Cl Η i-Pr ch3 ch2ch2scf3 Ph-4-S02CH3 Η i-Pr ch3 CH2SPh Cl Η i-Pr ch3 CH2SPh ch3 . Η i-Pr ch3 CH2SPh cf3 Η i-Pr ch3 CH2SPh och3 Η i-Pr ch3 CH2SPh sch3 Η i-Pr ch3 CH2SPh n(ch3)2 Η i-Pr ch3 CH2SPh Ph-4-F Η i-Pr ch3 CH2SPh Pii - 4-C1 Η i-Pr ch3 CH2SPh Ph-4-S02CH3 Η i-Pr ch3 CH2SPh L - 46d Η i-Pr ch3 CN Ph-4-Cl Η i-Pr ch3 C(CH3)=N0CH3 ch3 Η i-Pr ch3 T - 22 ch3 Η i-Pr ch3 T - 23 ch3 Η i-Pr ch3 T-24 ch3 Η i-Pr ch3 Ph ch3 Η i-Pr ch3 Ph cf3 Η i-Pr ch3 Ph Ph-4-C1 Η i-Pr ch3 Ph Ph-4-S02CH3 Η i-Pr ch3 Ph-2-F ch3 Η i-Pr ch3 Ph-3-F ch3
228 314918 200407073 Η i - Pr ch3 Ph+F Cl Η i - Pr ch3 Ph~4_F Br Η i-Pr ch3 Ph-4-F ch3 Η i - Pr ch3 Ph+F 〇ch3 Η i-Pr ch3 Ph-4-F sch3 Η i_Pr ch3 Ph-4-F n(ch3)2 Η i-Pr ch3 Ph-4-F Ph-4-Cl Η i-Pr ch3 Ph-4-F Ph-4-S02CH Η i-Pr ch3 Ph-2-Cl ch3 Η i-Pr ch3 Ph-3-Cl ch3 Η i-Pr ch3 Ph-4-Cl Cl Η i-Pr ch3 Ph-4-Cl Br Η i-Pr ch3 Ph-4-Cl ch3 Η i - Pr ch3 Ph-4-C1 Et Η i-Pr ch3 Ph-4-Cl n-Pr Η i-Pr ch3 Ph-4-Cl i-Pr Η i-Pr ch3 Ph-4-C1 c-Pr Η i - Pr ch3 Ph+Cl cf3 Η i-Pr ch3 Ph-4-C1 och3 Η i-Pr ch3 Ph-4-Cl OPr - i Η i-Pr ch3 Ph-4-Cl OCH2CF3 Η i-Pr ch3 Ph_4-Cl 0CH(CF3) 2 Η i-Pr ch3 Ph-4-Cl sch3 Η i-Pr ch3 Ph-4-Cl N(CH3) 2 Η i-Pr ch3 Ph-4-Cl Ph-4-Cl Η i-Pr ch3 Ph-4-Cl Ph-4-S02CH: Η i-Pr ch3 Ph-4-Br Cl Η i-Pr ch3 Ph~4~*Br ch3 Η i-Pr ch3 Ph-4-Br och3 Η i-Pr ch3 Ph-4-I ch3 Η i-Pr ch3 Ph-4-CH3 ch3 Η i - Pr ch3 Ph-4-Et ch3 Η i-Pr ch3 Ph-4-CF3 Cl Η i-Pr ch3 Ph-4-CF3 ch3 Η i-Pr ch3 Ph-4-CF3 och3 Η i-Pr ch3 Ph-4-CH20CH3 ch3 Η i-Pr ch3 Ph-4-CH2SCH3 ch3
229 314918 200407073 H i-Pr CH3 H 卜Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i~Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr . CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
Ph - 4-CH2S(0)CH3 ch3 Pli-4 - CH2S02CH3 ch3 Ph-4-CH2SCF3 ch3 Ph-4-CH2S(0) CF3 ch3 Ph-4-CH2S02CF3 ch3 Ph+0CH3 ch3 Ph-4-0CHF2 ch3 Ph-4-0CF3 Cl Ph-4-0CF3 Br Ph-4-OCFs ch3 Ph-4-0CF3 Et Ph-4-0CF3 n-Pr Ph-4-0CF3 i-Pr Ph-4-0CF3 c-Pr Ph-4-0CF3 chf2 Ph-4-0CF3 cf3 Ph-4_0CF3 och3 Ph-4-0CF3 OEt . Ph-4-0CF3 OPr-n Ph-4-0CF3 OPr - i Ph-4-0CF3 OCH2CF3 Ph-4-0CF3 OCH (CF3)2 Ph-4-0CF3 sch3 Ph-4-0CF3 SEt Ph-4-0CF3 SPr - n Ph-4-0CF3 SPr-i Ph-4-0CF3 N(CH3)2 Ph-4-0CF3 N(CH3)Et Ph-4-0CF3 N(Et)2 Ph-4-0CF3 Ph-4-Cl Ph-4-0CF3 Ph-4-S02CH3 Ph-4-0CF2Br Cl Ph-4-0CF2Br ch3 Ph-4-0CF2Br 〇ch3 Ph-4-0CF2CHF2 Cl Ph_4_0CF2CHF2 ch3 Ph-4-0CF2CHF2 OCH, 230 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
Ph-4-0CF2CHFCl ch3 Ph-4-0CF2CHFCF3 Cl Ph-4-0CF2CHFCF3 ch3 Ph-4-0CF2CHFCF3 och3 Ph-4-0CF2CHF0CF3 Cl Ph-4_0CF2CHF0CF3 ch3 Ph-4-0CF2CHF0CF3 och3 Ph-4-0CF2CHF0CF2CF2CF3 Cl Ph-4-0CF2CHF0CF2CF2CF3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 och3 Ph-4-0S02CH3 ch3 Ph-4-0S02CF3 ch3 Ph-4-0 (Ph-4-CF3) Cl Ph-4_0 (Ph-4-CF3) Br Ph-4-0 (Ph-4-CF3) ch3 Ph-4-0 (Ph-4-CF3) och3 Ph-4-0 (Ph-4-CF3) sch3 Ph-4-0 (Ph-4-CF3) N(CH3)2 Ph-4-0 (L-45g) Cl Ph-4-0 (L-45g) Br Ph-4-0 (L-45g) ch3 Ph-4-0 (L-45g) och3 Ph-4-0 (L-45g) sch3 Ph-4-0 (L-45g) N(CH3)2 Ph-4-0 (L-451) ch3 Ph-4-SCH3 ch3 Ph-4-S (0) CH3 ch3 Ph-4-S02CH3 ch3 Ph-4-SCH2F ch3 Ph-4-SCHF2 ch3 Ph-4-SCF3 ch3 Ph-4-SCF2Cl ch3 Ph-4-SCF2Br ch3 Ph - 4'N02 ch3 Ph-4-CN ch3 Ph-2,3-F2 ch3 Ph-2, 4-F2 ch3 231 314918 200407073 Η 卜Ργ ch3 Ph-2, 5-F2 CH Η i-Pr ch3 Ph-3, 4-F2 CH Η 卜Pr ch3 Ph-3, 5-F2 CH Η i - Pr ch3 Ph-2 - CH-F CH Η i-Pr ch3 Ph_2-F-3-C1 CH Η i - Pr ch3 Ph-3-CH-F CH Η i-Pr ch3 Ph-2-F-4-C1 CH Η i_Pr ch3 Ph-3-F-4-Cl CH Η i-Pr ch3 Ph-2, 3-Cl2 CH, Η i-Pr ch3 Ph-2, 4&lt;\2 CH, Η i-Pr ch3 Ph-2, 5-Cl 2 CH； Η i-Pr ch3 Ph-3,4-Cl2 CH； Η i-Pr ch3 Ph-3,5-Cl2 CH； Η i-Pr ch3 Ph_3_Br-4HF CH： Η i-Pr ch3 Ph-2-F-4-Br CH； Η i-Pr ch3 Ph-2-F-5-Br CH； Η i-Pr ch3 Ph-3, 4-Br2 CH： Η i-Pr ch3 Ph~3,5~Br 2 CH： Η i-Pr ch3 Ph-3-CH3-4-F CH: Η i-Pr ch3 Ph-3~F~4-CH3 CH： Η i-Pr ch3 Ph-2-F-5-CH3 CH, Η i-Pr ch3 Ph-2-F-3-CF3 CH, Η i-Pr ch3 Ph-3-CF3-4-F CH, Η i-Pr ch3 Ph-3_CF 3~4~C1 ch3 Η i-Pr ch3 Ph_2-F-4-CF 3 CHa Η i-Pr ch3 Ph-3-F-4-CF3 ch3 Η i-Pr ch3 Ph-2-Cl-4-CF3 ch3 Η i-Pr ch3 Ph-2-F-5-CF3 ch3 Η i-Pr ch3 Ph-3 - F+CF3 ch3 Η i-Pr ch3 Ph-3-0CH3-4-F ch3 Η i-Pr ch3 Ph-2-F-4-0CH3 ch3 Η i-Pr ch3 Ph-3-Cl-4-0CH3 ch3 Η i-Pr ch3 Ph-3-Br-4-0CH3 CH3 Η i-Pr ch3 Ph-2-F-5-0CH3 CH3 Η i-Pr ch3 Ph-3-F-4-0CHF2 ch3 Η i-Pr ch3 Ph-3-Cl-4~0CHF2 ch3 Η i-Pr ch3 Ph-3-Br-4-0CHF2 ch3 232 314918 200407073 H i - Pr ch3 Ph-3-F-4-0CF3 CH H i-Pr ch3 Ph-3-Cl-4-0CF3 CH Η i-Pr ch3 Ph-3-Br-4-0CF3 CH Η i-Pr ch3 Ph-3-F-4-0CF2Br CH Η i-Pr ch3 Ph-2,3,4HF3 CH Η i-Pr ch3 Ph-2, 3,5-F3 CH Η i-Pr ch3 Ph-2,4,5-F3 CH Η i-Pr ch3 Ph-3, 4,5-F3 CH Η i - Pr ch3 Ph-2, 3-F2-4-CH3 CH, H i-Pr ch3 Ph-2, 3-F2~4-CF3 CH, Η i-Pr ch3 Ph - 3,4-F2-5-CF3 CH； Η i-Pr ch3 1-Naph CH； Η i-Pr ch3 2-Naph CH； Η i-Pr ch3 L-lb CH； Η i-Pr ch3 L-lc CH； Η i-Pr ch3 L - Id CH； Η i-Pr ch3 L - le CH； Η i-Pr ch3 L- li CH： Η i-Pr ch3 L - 2b CH： Η i-Pr ch3 L-3c CH； Η i-Pr ch3 L - 3d CH： Η i-Pr ch3 L - 3e CH： Η i-Pr ch3 L - 3i CH, Η i-Pr ch3 L-3j CH, Η i-Pr ch3 L-3k CH, Η i-Pr ch3 L-31 CH, Η i-Pr ch3 L-3o CH, Η i-Pr ch3 L - 4b CH, Η i-Pr ch3 L-4c CH, Η i-Pr ch3 L - 4d CH, Η i-Pr ch3 L - 4e ch3 Η i-Pr ch3 L - 6a CH, Η i-Pr ch3 L - 6b ch3 Η i-Pr ch3 L - 6d ch3 Η i-Pr ch3 L-6e ch3 Η i-Pr ch3 L-lOb ch3 Η i-Pr ch3 L-lOc ch3 233 314918 200407073 i-Pr ch3 L-16a CH i-Pr ch3 L-16b CH i-Pr ch3 L-17a CH i-Pr ch3 L - 21b CH i-Pr ch3 L-21c CH i-Pr ch3 L-21e CH i-Pr ch3 L-22b CH i-Pr ch3 L-22c CH i-Pr ch3 L-23b CH i-Pr ch3 L - 23c CH i-Pr ch3 L-23i CH i-Pr ch3 L - 23g CH i-Pr ch3 L-25a CH i-Pr ch3 L - 25b CH i-Pr ch3 L - 25d CH i-Pr ch3 L~31a CH i-Pr ch3 L - 31b CH i-Pr ch3 L-38a CH； i-Pr ch3 L - 38b CH； i-Pr ch3 L - 45a CH： i-Pr ch3 L-45c CH： i-Pr ch3 L-45d CH； i-Pr ch3 L-45e CH； i-Pr ch3 L-45I CH； i-Pr ch3 L - 45g CH； i-Pr ch3 L - 45h CH； i-Pr ch3 L-45m CH； i-Pr ch3 L - 46a CH； i-Pr ch3 L-46c CH； i-Pr ch3 L - 46d CH； i-Pr ch3 L - 46e CH； i-Pr ch3 L - 46i CH； i-Pr ch3 L-46g CH； i - Pr ch3 L - 46j CH： i-Pr ch3 L-46k CH： i-Pr ch3 L - 46q CH： i-Pr ch3 L-46r CH, 234 314918 200407073 H i - Pr ch3 L - 47a ch3 H i-Pr ch3 L - 47e ch3 Η i-Pr ch3 L - 48b ch3 Η i-Pr ch3 L - 50b ch3 Η i-Pr ch3 L - 50c ch3 Η i-Pr ch3 L - 50d ch3 Η i-Pr ch3 L-51b ch3 Η i-Pr ch3 L - 53a ch3 Η i-Pr Et cf3 Cl Η i-Pr Et cf3 ch3 Η i-Pr Et cf3 och3 Η i-Pr Et cf3 sch3 Η i-Pr Et cf3 N(CH3)2 Η i-Pr Et cf3 Ph-4-F Η i-Pr Et cf3 Ph-4-Cl Η i-Pr Et cf3 Ph-4-0S02CH3 Η i-Pr Et cf3 Ph+SCH3 Η i-Pr Et cf3 Ph~4-S02CH3 . Η i-Pr Et cf3 Ph+CN Η i-Pr Et cf3 L-46d Η i-Pr Et Ph-4-F ch3 Η i-Pr Et Ph-4-Cl ch3 Η i-Pr Et Ph-4-0CF3 ch3 Η i-Pr n-Pr cf3 Ph-4-Cl Η i-Pr i-Pr Ph-4-0CF3 ch3 Η i-Pr n - Bu cf3 Ph-4-Cl Η i-Pr cf3 Ph-4-0CF3 ch3 Η i-Pr cf2cf3 cf3 Ph-4-Cl Η i-Pr ch2oh cf3 Cl Η i-Pr ch2oh cf3 ch3 Η i-Pr ch2oh cf3 och3 Η i-Pr ch2oh cf3 sch3 Η i-Pr ch2oh cf3 n(ch3)2 Η i-Pr ch2oh cf3 Ph-4-F Η i-Pr ch2oh cf3 Ph-4-Cl Η i-Pr ch2oh cf3 Ph-4-0S02CH3 Η i-Pr ch2oh cf3 Ph-4 - SC.H3
235 314918 200407073 Η i - Pr CH20H cf3 Ph-4-S02CH3 Η i-Pr ch2oh cf3 Ph-4-CN Η i-Pr ch2oh cf3 L-46d Η i-Pr ch2oh Ph-4-F ch3 Η i-Pr ch2oh Ph-4-Cl ch3 Η i-Pr ch2oh Ph-4_0CF3 ch3 Η i-Pr 〇ch3 cf3 Ph-4-C1 Η i-Pr och3 Ph-4-0CF3 ch3 Η i-Pr OEt cf3 Pli-4-Cl Η i-Pr OPr-1 Ph-4-0CF3 ch3 Η i-Pr 〇cf3 cf3 Ph-4-Cl Η i-Pr OPh Ph-4-OCF3 ch3 Η i-Pr sch3 cf3 Ph-4-Cl Η i-Pr sch3 Ph-4-OCF 3 ch3 Η i-Pr SEt cf3 Ph+Cl Η i-Pr SPr-I Ph-4-0CF3 ch3 Η i-Pr schf2 cf3 Ph-4-Cl Η i-Pr n(ch3)2 Ph-4-0CF3 ch3 . Η i-Pr CN cf3 Ph-4-Cl Η i-Pr Ph Ph_4-0CF3 ch3 Η i-Pr L - 14a cf3 Ph+Cl Η i-Pr L-14b Ph-4-0CF3 ch3 Η i-Pr L - 14d cf3 Ph-4-Cl Η i-Pr L-14i Ph-4-0CF3 ch3 Η i-Pr L - 14h cf3 Ph-4-Cl ch3 i-Pr ch3 cf3 Ph-4-Cl ch3 i - Pr ch3 Ph-4-0CF3 ch3 Et i-Pr ch3 cf3 Ph~4~S〇2CH3 Et i - Pr ch3 Ph-4-OCF3 ch3 i-Pr i-Pr ch3 cf3 Ph-4-F i - Pr i-Pr ch3 Ph-4_0CF3 ch3 CH20CH3 i-Pr ch3 cf3 Ph-4-Cl ch2och3 i-Pr ch3 Ph-4-OCF3 ch3 H c-Pr ch3 cf3 Ph~4~F H c-Pr ch3 cf3 Ph-4-Cl H c-Pr ch3 cf3 Ph-4-0S02CH3 H c-Pr ch3 cf3 Ph-4-SCH3
236 314918 200407073 Η c-Pr ch3 cf3 Ph-4 - S(0)CH Η c-Pr ch3 cf3 Ph-4-S02CH3 Η c-Pr ch3 cf3 Ph-4-N02 Η c-Pr ch3 cf3 Ph-4-CN Η c-Pr ch3 cf3 Ph-4-C (0) NH； Η c-Pr ch3 cf3 Ph-4-C (S)NH： Η c-Pr ch3 cf3 Ph-3,4-Cl2 Η c-Pr ch3 cf3 L-46d Η c-Pr ch3 cf3 L-47a Η c-Pr ch3 cf3 L-47e Η c-Pr ch3 Ph-4-F ch3 Η c-Pr ch3 Ph-4-Cl ch3 Η c-Pr ch3 Ph-4-Br ch3 Η c-Pr ch3 Ph-4-I ch3 Η c-Pr ch3 Ph-4-CF3 ch3 Η c-Pr ch3 Ph-4-0CHF2 ch3 Η c-Pr ch3 Ph-4-0CF3 ch3 Η c-Pr ch3 Ph-4-0CF2Br ch3 Η c-Pr ch3 Ph-4-0CF2CHF2 ch3 Η c-Pr ch3 Ph-4-0CF2CHFCl ch3 Η c_Pr ch3 Ph-4-0CF2CHFCF3 ch3 Η c-Pr ch3 Ph-4-0CF2CHF0CF: 3CH3 Η c-Pr ch3 Ph-4-CN ch3 Η c-Pr ch3 Ph~3, 4~F 2 ch3 Η c-Pr ch3 Ph-3-F-4-C1 ch3 Η c-Pr ch3 Ph-3, 4-Cl2 ch3 Η n-Bu ch3 cf3 Ph-4-F Η n~Bu ch3 cf3 Ph-4-Cl Η n-Bu ch3 cf3 Ph-4-0S02CH: Η n-Bu ch3 cf3 Ph+SCH3 Η n-Bu ch3 cf3 Ph-4-S (0) CH, Η n-Bu ch3 cf3 Ph+S02CH3 Η n-Bu ch3 cf3 Ph-4-N02 Η n-Bu ch3 cf3 Ph-4-CN Η n-Bu ch3 cf3 Ph-4-C (0) NH5 Η n-Bu ch3 cf3 Ph-4 - C(S)NH, Η n-Bu ch3 cf3 L-46d
237 314918 200407073 H n-Bu CH3 H n-Bu CH3 H n-Bu CH3 H i-Bu CH3 H i-Bu CH3 H i-Bu CH3 H i-Bu CH3 CH3 i-Bu CH3 CH3 i-Bu CH3 H CH2Pr_c CH3
H s-Bu F H s-Bu Cl H s-Bu Cl H s-Bu Br H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3 H s-Bu CH3
Ph~4~F ch3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 cf3 Ph-4-F cf3 Ph+Cl cf3 Ph-4-S02CH3 Ph-4-0CF3 ch3 cf3 Ph-4-Cl Ph-4-0CF3 ch3 cf3 Ph-4-S02CH3 cf3 Ph-4-F cf3 Ph-4-Cl ' Ph-4-0CF3 ch3 cf3 Ph~4-S02CH3 ch3 Ph-4-F ch3 Ph-4-Cl ch3 Ph-4-S02CH3 ch3 L-46d . Et Ph+F Et Ph-4-Cl Et Ph+S02CH3 Et L-46d n-Pr Ph-4-F i-Pr Ph_4-S〇2 CH3 chf2 L-46d cf3 Cl cf3 ch3 cf3 och3 cf3 sch3 cf3 N(CH3)2 cf3 Ph-4-F cf3 Ph-4-Cl cf3 Ph-4-Br cf3 Ph-4-I cf3 Ph-4-CF3 cf3 Ph-4-CH2SCH3 cf3 Ph-4-CH2S02CH3 238 314918 200407073 Η s-Bu ch3 cf3 Ph-4-CH2SCF3 Η s-Bu ch3 cf3 Ph-4-CH2S02CF： Η s - Bu ch3 cf3 Ph-4-0CHF2 Η s - Bu ch3 cf3 Ph_4-OCF 3 Η s-Bu ch3 cf3 Ph-4-0S02CH3 Η s-Bu ch3 cf3 Ph-4-SCH3 Η s-Bu ch3 cf3 Ph - 4-S(0)CH3 Η s-Bu ch3 cf3 Ph_4-SO2CH3 Η s-Bu ch3 cf3 Ph_4-SEt Η s-Bu ch3 cf3 Ph-4-S (O)Et Η s-Bu ch3 cf3 Ph_4~S〇2Et Η s-Bu ch3 cf3 Ph-4-SPr-n Η s-Bu ch3 cf3 Ph-4-S (O)Pr-n Η s-Bu ch3 cf3 Ph-4-S02Pr-n Η s-Bu ch3 cf3 Ph-4-SPr-i Η s-Bu ch3 cf3 Ph-4 - S(0)Pr- i Η s-Bu ch3 cf3 Ph-4-S02Pr-i Η s-Bu ch3 cf3 Ph-4-SCHF2 . Η s-Bu ch3 cf3 Ph-4-S (0) CHF2 Η s-Bu ch3 cf3 Ph-4-S02CHF2 Η s-Bu ch3 cf3 Ph-4-SCF3 Η s-Bu ch3 cf3 Ph+S(0)CF3 Η s-Bu ch3 cf3 Ph-4-SO2CF3 Η s-Bu ch3 cf3 Ph-4-SCF2Cl Η s-Bu ch3 cf3 Ph-4-S (0) CF2C1 Η s-Bu ch3 cf3 Ph-4-S02CF2Cl Η s-Bu ch3 cf3 Ph-4-SCF2Br Η s-Bu ch3 cf3 Ph-4-S (0) CF2Br Η s-Bu ch3 cf3 Ph-4-S02CF2Br Η s-Bu ch3 cf3 Ph-4-N02 Η s-Bu ch3 cf3 Ph-4-CN Η s-Bu ch3 cf3 Ph-4-C(0)NH2 Η s-Bu ch3 cf3 Ph-4-C (S) NH2 Η s-Bu ch3 cf3 Ph - 3,4-F2 Η s-Bu ch3 cf3 Ph~3-F_4-C] Η s-Bu ch3 cf3 Ph-3, 4-Cl2 Η s-Bu ch3 cf3 L-lb 239 314918 200407073 Η s-Bu ch3 cf3 L~lc Η s-Bu ch3 cf3 L-lf Η s-Bu ch3 cf3 L-lg Η s-Bu ch3 cf3 L-li Η s-Bu ch3 cf3 L-2b Η s-Bu ch3 cf3 L-3b Η s-Bu ch3 cf3 L-3c Η s-Bu ch3 cf3 L-3d Η s-Bu ch3 cf3 L-3g Η s-Bu ch3 cf3 L - 3h Η s-Bu ch3 cf3 L-3i Η s-Bu ch3 cf3 L - 3j Η s-Bu ch3 cf3 L-3k Η s-Bu ch3 cf3 L-31 Η s-Bu ch3 cf3 L - 3m Η s-Bu ch3 cf3 L-3n Η s-Ba ch3 cf3 L-4b Η s-Bu ch3 cf3 L - 4c Η s-Bu ch3 cf3 L - 4d Η s-Bu ch3 cf3 L - 4e Η s-Bu ch3 cf3 L-lOb Η s-Bu ch3 cf3 L- 10c Η s-Bu ch3 cf3 L-lOd Η s-Bu ch3 cf3 L-14b Η s-Bu ch3 cf3 L-14c Η s-Bu ch3 cf3 L- 14d Η s-Bu ch3 cf3 L-14f Η s-Bu ch3 cf3 L-14h Η s-Bu ch3 cf3 L- 17a Η s-Bu ch3 cf3 L-21b Η s-Bu ch3 cf3 L-22b Η s-Bu ch3 cf3 L - 22c Η s-Bu ch3 cf3 L - 22d Η s-Bu ch3 cf3 L-23b Η s-Bu ch3 cf3 L-23c Η s-Ba ch3 cf3 L-23e Η s-Bu ch3 cf3 L - 24b
240 314918 200407073 Η s-Bu ch3 cf3 L - 24c Η s-Bu ch3 cf3 L - 24d Η s-Bu ch3 cf3 L-24e Η s-Bu ch3 cf3 L-31a Η s-Bu ch3 cf3 L - 31b Η s-Bu ch3 cf3 L_31c Η s-Bu ch3 cf3 L-36c Η s-Bu ch3 cf3 L - 36d Η s-Bu ch3 cf3 L - 45d Η s-Bu ch3 cf3 L-45e Η s-Bu ch3 cf3 L-45g Η s-Bu ch3 cf3 L-45m Η s-Bu ch3 cf3 L-46d Η s-Bu ch3 cf3 L-46e Η s-Bu ch3 cf3 L-46g Η s-Bu ch3 cf3 L-46j Η s-Bu ch3 cf3 L-46k Η s-Bu ch3 cf3 L - 46m Η s-Bu ch3 cf3 L - 46n Η s-Bu ch3 cf3 L-46o Η s-Bu ch3 cf3 L - 46p Η s-Bu ch3 cf3 L-46r Η s-Bu ch3 cf3 L-47a Η s-Bu ch3 cf3 L-47e Η s-Bu ch3 cf3 L-48b Η s-Bu ch3 cf3 L-50b Η s-Bu ch3 cf3 L-50c Η s-Bu ch3 cf3 L-50e Η s-Bu ch3 cf3 L-51b Η s-Bu ch3 cf3 L-51c Η s-Bu ch3 cf2ci Ph一4-F Η s-Bu ch3 cf2cf3 Ph-4-S02CH3 Η s-Bu ch3 Ph-4-F ch3 Η s-Bu ch3 Ph-4-C1 ch3 Η s-Bu ch3 Ph-4-Br ch3 Η s-Bu ch3 PH -1 ch3 Η s-Bu ch3 Ph-4-CF3 ch3
241 314918 200407073 Η s-Bu ch3 Ph-4_0CHF2 ch3 Η s-Bu ch3 Ph-4-0CF3 ch3 Η s-Bu ch3 Ph^4**0CF2Br ch3 Η s-Bu ch3 Ph-4-0CF2CHF2 ch3 Η s-Bu ch3 Ph-4_0CF2CHFC1 ch3 Η s-Bu ch3 Ph-4-0CF2CHFCF3 ；ch3 Η s-Bu ch3 Ph-4-0CF2CHF0CF3CH3 Η s-Bu ch3 Ph-4-CN ch3 Η s-Bu ch3 Ph-3. 4-F2 ch3 Η s-Bu ch3 Ph-3-F-4_C1 ch3 Η s-Bu ch3 Ph-3,4-Cl2 ch3 Η s-Bu ch3 L - lc ch3 • Η s-Bu ch3 L - Id ch3 Η s-Bu ch3 L-le ch3 Η s-Bu ch3 L-li ch3 Η s-Bu ch3 L-2b ch3 Η s-Bu ch3 L - 3d ch3 Η s-Bu ch3 卜3e ch3 Η s-Bu ch3 L-3f ch3 Η s-Bu ch3 L-31 ch3 Η s-Bu ch3 L - 3o ch3 Η s-Bu ch3 L_4c ch3 Η s-Bu ch3 L- 10c ch3 Η s-Bu ch3 L - 22c ch3 • Η s-Bu ch3 L-23c ch3 Η s-Bu ch3 L - 45e ch3 Η s-Bu ch3 L - 45i ch3 Η s-Bu ch3 L - 45g ch3 Η s-Bu ch3 L - 45m ch3 Η s-Bu ch3 L_46d ch3 Η s-Bu ch3 L - 46e ch3 Η s-Bu ch3 L - 46i ch3 Η s-Bu ch3 L - 46g ch3 Η s-Bu ch3 L - 46j ch3 Η s-Bu ch3 L-46k ch3 Η s-Bu ch3 L - 46r ch3 Η s-Bu ch3 L-47a ch3 242 314918 200407073 H s-Bu CH3
H t-Bu F H 卜Bu Cl H t-Bu Cl H t-Bu Br H 卜Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Βυ CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 H t-Bu CH3 L-47e ch3 cf3 Ph-4-Cl cf3 Ph+S02CH3 Ph-4_0CF3 ch3 cf3 Ph~4~F ch3 Ph-4-F ch3 Ph-4-C1 ch3 Ph-4-S02CH3 ch3 L-46d Et Ph-4-F Et Ph-4-C1 Et Ph-4-S02CH3 ’ Et L-46d n - Pr Ph-4-F i-Pr Ph-4-S02CH3 chf2 L - 46d cf3 Cl cf3 ch3 . cf3 och3 cf3 sch3 cf3 N(CH3)2 cf3 Ph-4-F cf3 Ph-4-Cl cf3 Ph~4~Br cf3 Ph-4-I cf3 Ph-4-CF3 cf3 Ph-4-CH2SCH3 cf3 Ph-4-CH2S02CH3 cf3 Ph-4-CH2SCF3 cf3 Ph-4-CH2S02CF3 cf3 Ph-4-0CHF2 cf3 Ph-4-0CF3 cf3 Ph-4-0S02CH3 cf3 Ph-4~0S02CF3 cf3 Ph-4-SCHa cf3 Ph-4 - S(0)CH3 cf3 Ph-4'S02CH3 243 314918 200407073 t-Bu ch3 cf3 Ph-4-SEt t - Bu ch3 cf3 Ph~4 - S (0) Et t-Bu ch3 cf3 Ph+S02Et t-Bu ch3 cf3 Ph-4-SPr-n t-Bu ch3 cf3 Ph+S(0)Pr-n t-Bu ch3 cf3 Ph-4-S02Pr-n t-Bu ch3 cf3 Ph-4-SPr-i t-Bu ch3 cf3 Ph-4-S (O)Pr-i t - Bu ch3 cf3 Ph-4-S02Pr-i t_Bu ch3 cf3 Ph-4-SCHF2 t-Bu ch3 cf3 Ph-4-S (0) CHF2 t-Bu ch3 cf3 Ph-4-S02CHF2 ' t-Bu ch3 cf3 Ph-4-SCF3 t-Bu ch3 cf3 Ph - 4-S(0)CF3 t-Bu ch3 cf3 Ph-4-S02CF3 t~Bu ch3 cf3 Ph-4-SCF2Cl t-Bu ch3 cf3 Ph_4 - S(0)CF2C1 t-Bu ch3 cf3 Ph - 4-S02CF2C.l t-Bu ch3 cf3 Ph-4-SCF2Br t-Bu ch3 cf3 Ph-4-S (0) CF2Br t-Bu ch3 cf3 Ph-4-S02CF2Br t-Bu ch3 cf3 Ph-4-N02 t-Bu ch3 cf3 Ph-4-CN t-Bu ch3 cf3 Ph-4-C (0) NH2 t-Bu ch3 cf3 Ph-4-C (S) NH2 t-Bu ch3 cf3 Ph-3, 4-F2 t_Bu ch3 cf3 Ph-3-F-4-C1 t-Bu ch3 cf3 Ph-3, 4-Cl2 t-Bu ch3 cf3 L-lb t-Bu ch3 cf3 L - lc t-Bu ch3 cf3 L - le t-Bu ch3 cf3 L-lf t - Bu ch3 cf3 L-lg t-Bu ch3 cf3 L-li t-Bu ch3 cf3 L-2b t-Bu ch3 cf3 L-3c t~Bu ch3 cf3 L-3h
244 314918 200407073 Η Η t - Bu ch3 cf3 L-3i t-Bu ch3 cf3 L-3j t_Bii ch3 cf3 L-3k t - Bu ch3 cf3 L_3m t-Bu ch3 cf3 L - 3n t-Bu ch3 cf3 L-4b t-Bu ch3 cf3 L - 4e t-Bu ch3 cf3 L-lOb t-Bu ch3 cf3 L-10c t-Bu ch3 cf3 L-lOd t_Bu ch3 cf3 L-14b t-Bu ch3 cf3 L-14f t - Bu ch3 cf3 L - 17a t-Bu ch3 cf3 L-21b t_Bii ch3 cf3 L - 22b t-Bu ch3 cf3 L-22c t-Bu ch3 cf3 L - 22d t-Bu ch3 cf3 L - 23b t-Bu ch3 cf3 L - 23c t-Bu ch3 cf3 L-23e t_Bu ch3 cf3 L - 24b t-Bu ch3 cf3 L - 24c t - Bu ch3 cf3 L-24e t-Bu ch3 cf3 L-31a t-Bu ch3 cf3 L-31b t-Bu ch3 cf3 L~3 lc t-Bu CHa cf3 L-36c t-Bu ch3 cf3 L-36d t-Bu ch3 cf3 L - 45d t-Bu ch3 cf3 L-45e t-Bu ch3 cf3 L - 45g t-Bu ch3 cf3 L-45m t-Bu ch3 cf3 L-46d t~Bu CHa cf3 L-46e t_Bu ch3 cf3 L-46g t-Bu ch3 cf3 L-46j t-Bu ch3 cf3 L - 46k 245 314918 200407073 t_Bu ch3 cf3 L - 46m t-Bu ch3 cf3 L-46n t-Bu ch3 cf3 L-46o t~Bu ch3 cf3 L-46p t-Bu ch3 cf3 L-46r t-Bu ch3 cf3 L - 47a t-Bu ch3 cf3 L - 47e t - Bu ch3 cf3 L-48b t-Bu ch3 cf3 L-50b t-Bu ch3 cf3 L-50c t-Bu ch3 cf3 L-50e t-Bu ch3 cf3 L-51b t-Bu ch3 cf3 L-5 lc t-Bu ch3 cf2ci Ph-4-F t-Bu ch3 cf2cf3 Ph-4-S02CH t-Bu ch3 Ph-4-F ch3 t-Bu ch3 Ph-4-Cl ch3 t-Bu ch3 Ph-4-Br ch3 t-Bu ch3 Ph-4-CF3 ch3 t-Bu ch3 Ph-4-0CHF2 ch3 t-Bu ch3 Ph-4-0CF3 ch3 t-Bu ch3 Ph-4-0CF2Br ch3 t-Bu ch3 Ph-4-0CF2CHF2 ch3 t-Bu ch3 Ph-4-0CF2CHFCl CH t-Bu ch3 Pb-4_0CF2CHFCF3 CH t-Bu ch3 Ph-4-0CF2CHF0CF: 3 CH t-Bu ch3 Ph-4-CN ch3 t-Bu ch3 Ph-3, 4-F2 ch3 t-Bu ch3 Ph-3-F-4-Cl ch3 t~Bu ch3 Ph-3,4-Cl2 ch3 t-Bu ch3 L-lc ch3 t-Bu ch3 L - Id ch3 t-Bu ch3 L - le ch3 t-Bu ch3 L-li ch3 t-Bu CHa L-2b ch3 t~Bu ch3 L-3d ch3 t-Bu ch3 L-3e ch3
246 314918 200407073 Η t~Bu ch3 L-3i ch3 Η t-Bu ch3 L - 31 ch3 Η t-Bu ch3 L-3o ch3 Η t_Bu ch3 L-4c ch3 Η t-Bu ch3 L-4e ch3 Η t_Bu ch3 L-21c ch3 Η t-Bu ch3 L - 21e ch3 Η t-Bu ch3 L - 22c ch3 Η t-Bu ch3 L-23c ch3 Η t-Bu ch3 L_3 lb ch3 Η t-Bu ch3 L-45e ch3 Η t-Bu ch3 L-45f ch3 Η t-Bu ch3 L - 45g ch3 Η t-Bu ch3 L-45m ch3 Η t_Bu ch3 L - 46e ch3 Η t-Bu ch3 L-46f ch3 Η t - Bu ch3 L-46g ch3 Η t-Bu ch3 L-46j ch3 Η t-Bu ch3 L - 46k ch3 Η t-Bu ch3 L-46r ch3 Η t - Bu ch3 L-47a ch3 Η t-Bu ch3 L-47e ch3 Η c_Bu ch3 cf3 L - 46d Η n - Pen ch3 cf3 Ph-4-Cl Η CH2CH2Pr-I ch3 Ph-4-0CF3 ch3 Η CH2CH(CH3)Et ch3 cf3 Ph-4_C1 Η CH2Bu-t ch3 Ph-4-0CF3 ch3 Η CH (CH3)Pr-n ch3 cf3 Ph-4-F Η CH (CH3)Pr-n ch3 cf3 Ph-4-Cl Η CH(CH3)Pr - n ch3 cf3 Ph-4-0S02CH3 Η CH(CH3)Pr-n ch3 cf3 Ph-4-SCH3 Η CH (CH3)Pr-n ch3 cf3 Ph-4-S (0) CH3 Η CH(CH3)Pr - n ch3 cf3 Ph-4-S02CH3 Η CH (CH3)Pr-n ch3 cf3 Ph+CN Η CH (CH3)Pr-n ch3 cf3 L - 46d Η CH (CH3)Pr-n ch3 Ph_4_F ch3 Η CH(CH3)Pr-n ch3 Ph-4-Cl ch3
247 3149]8 200407073 Η CH (CH3)Pr-n ch3 Ph-4-0CF3 ch3 Η CH (CH3)Pr-i ch3 cf3 Ph-4-Cl Η CH (Et)2 ch3 Ph~4~0CF 3 ch3 Η C(CH3) 2Et ch3 cf3 Ph-4-F Η C(CH3)2Et ch3 cf3 Ph-4-C1 Η C(CH3) 2Et ch3 cf3 Ph-4-S02CH3 Η C(CH3)2Et ch3 Ph-4-C1 ch3 Η C(CH3) 2Et ch3 Ph&gt;4-0CF3 ch3 Η c-Pen ch3 cf3 Ph-4-Cl Η c-Pen ch3 cf3 Ph-4-S02CH3 Η n-Hex ch3 cf3 Ph-4-Cl Η n-Hex ch3 cf3 Ph-4-S02CH3 ' • Η CH(CH3)Bu - i ch3 cf3 Ph-4-C1 Η CH (CH3)Bu-i ch3 cf3 Ph-4-S02CH3 Η C(CH3) 2Pr-n ch3 cf3 Ph-4-F Η C(CH3) 2Pr-n ch3 cf3 Ph-4-Cl Η C(CH3) 2Pr-n ch3 cf3 Ph+S02CH3 Η C(CH3)2Pr-n ch3 cf3 Ph-4_CN . Η C(CH3) 2Pr-n ch3 cf3 L-46d Η C(CH3)2Pr-n ch3 Ph-4-F ch3 Η C(CH3)2Pr - n ch3 Ph-4-Cl ch3 Η C.(CH3) 2Pr-n ch3 Ph-4-0CF3 ch3 Η c-Hex ch3 cf3 Ph+Cl Η c-Hex ch3 cf3 Ph-4-S02CH3 • Η CH2Hex-c ch3 cf3 Ph-4-Cl Η Oct ch3 Ph-4-0CF3 ch3 Η C(CH3) 2CH2Bu-t ch3 cf3 Ph-4-S02CH3 -CH2CH2CH2CH2- ch3 cf3 PM-Cl -ch2ch2ch2ch2ch2- ch3 Ph+0CF3 ch3 -CH2CH2CH (CH3)CH2CH2- ch3 cf3 Ph-4-Cl - ch2ch(ch3)ch2ch(ch3)ch2_ ch3 Ph+OCF3 ch3 - ch2ch2ch2ch2ch2ch2- ch3 cf3 Ph+Cl Η CH2CH2F ch3 cf3 Ph+Cl Η ch2ch2f ch3 cf3 Ph-4-S02CH3 Η ch2ch2ci ch3 cf3 Ph+Cl Η ch2ch2ci ch3 cf3 Ph+S02CH3 Η ch2cf3 ch3 cf3 Ph-4-Cl 248 314918 200407073
H CH (CH3)CH2F
H CH (CH3)CH2F H CH (CH3)CH2F(S)
H CH (CH3)CH2F
H CH (CH3)CH2F
H CH (CH3)CH2F
H CH (CH3)CH2F
H CH (CH3)CH2F H CH (CH3)CH2C1 H CH (CH3)CH2C1 H CH (CH3)CH2C1 H CH (CH3)CH2C1 H CH (CH3)CH2C1 H CH (CH3)CH2C1 H CH (CH3)CH2C1 H CH (CH3)CH2Br(R) H CH (CH3)CH2Br(S) H CH (CH3)CH2Br H C(CH3) 2CH2C1 H C(CH3) 2CH2C1 H C(CH3)2CH2C1 H C(CH3) 2CH2C1 H C(CH3) 2CH2C1 H C(CH3) 2CH2C1 H C(CH3) 2CH2C1 H C(CH3) 2CH2Br H C(CH3)2CH2Br H C(CH3) 2CHBrCH2Br H CH20CH3 H CH2CH20CH3 H CH2CH20et CH2CH20Et CH2CH20Et CH2CH20Et CH2CH20Et H CH2CH20C (0) NHEt H CH2CH20Ph H CH2CH20(Ph-2-Cl) H CH2CH20(Ph-3-Cl) ch3 cf3 Ph-4-F ch3 cf3 Ph-4-Cl ch3 cf3 Ph-4-Cl ch3 cf3 Ph-4-S02CH3 ch3 cf3 L-46d ch3 Ph-4-F ch3 ch3 Ph+Cl ch3 ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-F ch3 cf3 Ph-4-Cl ch3 cf3 Ph-4-S02CH3 ch3 cf3 L-46d ch3 Ph-4-F ch3 ch3 Ph-4-Cl ch3 ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-F ch3 cf3 Ph-4-Cl ch3 cf3 Ph+S02CH3 ch3 cf3 L-46d ch3 Ph-4_F ch3 ch3 Ph-4-Cl ch3 ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-C1 ch3 Ph-4-OCFs ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4_0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-C1 ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3
249 314918 200407073 Η CH2CH20(Ph-4-Cl) ch3 cf3 Ph-4-Cl Η CH2CH (OH) CH3 ch3 Ph_4-OCF3 ch3 Η CH2CH (OH)Et ch3 cf3 Ph-4-Cl Η CH2CH (OH) Ph ch3 Ph-4-0CF3 ch3 Η CH2CH (OH) CH2Ph ch3 cf3 PM-Cl Η CH2C(CH3)2OSi(CH3)3 ch3 cf3 Pti-4_F Η CH2C(CH3) 2〇Si (CH3) a ch3 cf3 Ph-4-Cl Η CH2C(CH3) 2OSi (CH3) a ch3 cf3 Ph-4-0S02CH Η CH2C(CH3) 2〇Si(CH3)3 ch3 cf3 Ph-4_SCH3 Η CH2C(CH3) 2〇Si (CH3) 3 ch3 cf3 Ph-4-S (0) CH； Η CH2C(CH3)2OSi(CH3)3 ch3 cf3 Ph-4-S02CH3 Η CH2C(CH3)2OSi(CH3)3 ch3 cf3 Ph-4-NO2 Η CH2C(CH3) 2〇Si (CH3) a ch3 cf3 Ph-4-CN Η CH2C(CH3)2OSi(CH3)3 ch3 cf3 Ph-4-C (0) NH； Η CH2C(CH3) 2〇Si (CH3) a ch3 cf3 Ph-4 - C(S)NH: Η CH2C(CH3)2OSi(CH3)3 ch3 cf3 L-46d Η CH2C(CH3) 2〇Si(CH3) 3 ch3 Ph-4-F ch3 Η CH2C(CH3)2OSi(CH3)3 ch3 Ph-4-Cl ch3 Η CH2C(CH3)2OSi(CH3)3 ch3 Ph-4-Br ch3 Η CH2C(CH3) 2〇Si (CH3) a ch3 Ph-4-I ch3 Η CH2C(CH3)2OSi(CH3)3 ch3 Ph-4-CF3 ch3 Η CH2C(CH3)2OSi(CH3)3 ch3 Ph-4_0CF3 ch3 Η CH2CH (OEt) 2 ch3 cf3 Ph-4-C1 Η CH (CH3)CH2OH ch3 cf3 Ph_4~0CF 3 Η ch(ch3)ch2oh(r) ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2OH (S) ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2OH ch3 cf3 Ph-3,心Cl2 Η CH (CH3)CH2OH ch3 Ph-4-OCFa ch3 Η CH (CH3)CH2OCH3 ch3 ch3 Ph-4_F Η CH (CH3)CH2OCH3 ch3 ch3 Ph-4-C1 Η CH (CH3)CH2OCH3 ch3 ch3 Ph-4-S02CH3 Η CH (CH3)CH2OCH3 ch3 ch3 L-46d Η CH (CH3)CH2OCH3 ch3 Et Ph-4-F Η CH (CH3)CH2OCH3 ch3 n-Pr Ph-4-S02CH3 Η CH (CH3)CH2〇CH3 ch3 i-Pr L-46d Η CH (CH3)CH20CH3 ch3 chf2 Ph-4-F Η CH (CH3)CH2OCH3 ch3 cf3 Cl
250 314918 200407073 Η CH(CH3)CH2OCH3 ch3 CFs ch3 Η ch(ch3)ch2och3 ch3 cf3 och3 Η CH (CH3)CH20CH3 ch3 cf3 sch3 Η ch(ch3)ch2och3 ch3 cf3 N(CH3) 2 Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-F Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-Cl Η CH (CH3)CH20CH3 ch3 cf3 Ph_4-Br Η CH (CH3)CH20CH3 ch3 cf3 Ph+I Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-CF3 Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-0CHF2 Η CH (CH3)CH20CH3 ch3 cf3 Ph~4~0CF 3 Η CH (CH3)CH20CH3 ch3 cf3 Ph_4-0CF2Br Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-0CF2CHF2 Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-0CF2CHFCl Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-0CF2CHFCF3 Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-0CF2CHF0CF3 Η CH (CH3)CH20CH3 ch3 cf3 Ph-4~0CF2CHF0CF2CF2CF3 Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-0S02CIU Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-SCH3 Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-S (0) CH3 Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-S02CH3 Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-N02 Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-CN Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-C (0)NH2 Η CH(CH3)CH2OCH3 ch3 cf3 Ph-4-C (S) NH2 Η CH (CH3)CH20CH3 ch3 cf3 Ph-3, 4-F2 Η CH (CH3)CH20CH3 ch3 cf3 Ph-3-F-4-Cl Η CH (CH3)CH20CH3 ch3 cf3 Ph-3,4—Cl2 Η CH (CH3)CH20CH3 ch3 cf3 L-45d Η CH (CH3)CH20CH3 ch3 cf3 L - 45e Η CH (CH3)CH20CH3 ch3 cf3 L-45g Η CH (CH3)CH20CH3 ch3 cf3 L-45in Η CH (CH3)CH20CH3 ch3 cf3 L_46d Η CH (CH3)CH20CH3 ch3 cf3 L-46e Η CH (CH3)CH2〇CH3 ch3 cf3 L-46g Η CH (CH3)CH20CH3 ch3 cf3 L-46j Η CH (CH3)CH2〇CH3 ch3 cf3 L-46k 251 314918 200407073 Η CH (CH3)CH20CH3 ch3 cf3 L-46m Η CH (CH3)CH20CH3 ch3 cf3 L - 46o Η CH (CH3)CH20CH3 ch3 cf3 L - 46p Η CH (CH3)CH20CH3 ch3 cf3 L-46r Η CH (CH3)CH20CH3 ch3 cf3 L-47a Η CH (CH3)CH20CH3 ch3 cf3 L - 47e Η CH (CH3)CH20CH3 ch3 cf2ci Ph-4-S02CH Η CH (CH3)CH20CH3 ch3 CF2Br L - 46d Η CH (CH3)CH20CH3 ch3 cf2cf3 Ph-4-F Η CH (CH3)CH20CH3 ch3 Ph-4-F ch3 Η CH (CH3)CH20CH3 ch3 Ph-4-Cl ch3 Η CH (CH3)CH20CH3 ch3 Ph-4-Br ch3 Η CH (CH3)CH20CH3 ch3 Ph+CF3 ch3 Η CH (CH3)CH20CH3 ch3 Ph-4-0CHF2 ch3 Η CH (CH3)CH20CH3 ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH20CH3 ch3 Ph-4-0CF2Br ch3 Η CH (CH3)CH20CH3 ch3 Ph-4-0CF2CHF2 ch3 Η CH (CH3)CH20CH3 ch3 Ph-4-0CF2CHFCl ch3 Η CH (CH3)CH20CH3 ch3 Ph-4-0CF2CHFCF3 CH3 Η CH (CH3)CH20CH3 ch3 Ph-4-0CF2CHF0CF 3CH3 Η CH (CH3)CH20CH3 ch3 Ph-4_0CF2CHF0CF2CF2CF3 CH Η CH (CH3)CH20CH3 ch3 Ph-3, 4-F2 ch3 Η CH (CH3)CH20CH3 ch3 Ph-3-F-4-Cl ch3 Η CH (CH3)CH20CH3 ch3 Ph-3, 4-Cl 2 ch3 Η CH (CH3)CH20CH3 ch3 L-lc ch3 Η CH (CH3)CH20CH3 ch3 L-ld ch3 Η CH (CH3)CH20CH3 ch3 L-le ch3 Η CH (CH3)CH20CH3 ch3 L-li ch3 Η CH (CH3)CH20CH3 ch3 L-2b ch3 Η CH (CH3)CH20CH3 ch3 L~3d ch3 Η CH (CH3)CH20CH3 ch3 L-3e ch3 Η CH (CH3)CH20CH3 ch3 L-3i ch3 Η CH (CH3)CH20CH3 ch3 L-31 ch3 Η CH (CH3)CH20CH3 ch3 L - 3o ch3 Η CH (CH3)CH20CH3 ch3 L-4c ch3 Η CH (CH3)CH20Et ch3 cf3 Ph-4-Cl Η CH(CH3)CH2OPr-n ch3 Ph-4-0CF3 ch3
252 314918 200407073 Η CH(CH3)CH2OBu-i ch3 cf3 Ph-4-Cl Η CH (CH3)CH20CH2CH20CH3 ch3 Ph+0CF3 ch3 Η CH (CH3)CH2OCH2CH2SCH3 ch3 cf3 Ph-4-C1 Η CH (CH3)CH2OCH2CH2SEt ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2OCH2Ph ch3 cf3 Ph-4-Cl Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph+F Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-Cl Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-Br Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-I Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-CF3 Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-0CHF2 Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-0CF2Br Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-0CF2CHF2 Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4~0CF2CHFCF3 Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-CN Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-3, 4-F2 Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-3:F-4-C1 Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-3, 4-Cl2 Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-F ch3 Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-Cl ch3 Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-Br ch3 Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-CF3 ch3 Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-0CHF2 ch3 Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-0CF2Br ch3 Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-0CF2CHF2 ch3 Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-0CF2CHFCF3 CH3 Η CH (CH3)CH20C (0) ch3 ch3 Ph-3, 4-Cl2 ch3 Η CH (CH3)CH20C (0) cf3 ch3 cf3 Ph-4-Cl Η CH (CH3)CH20C (0)NHCH3 ch3 cf3 Cl Η CH (CH3)CH20C (0) nhch3 ch3 cf3 ch3 Η CH (CH3)CH20C (0) nhch3 ch3 cf3 och3 Η CH (CH3)CH20C (0)NHCH3 ch3 cf3 sch3 Η CH (CH3)CH20C (0)NHCH3 ch3 cf3 N(CH3)2 Η CH (CH3)CH20C (0)NHCH3 ch3 cf3 Ph-4-F Η CH (CH3)CH20C(0)NHCH3 ch3 cf3 Ph-4-Cl
253 314918 200407073 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0)NHCH3 H CH (CH3)CH20C (0)NHCH3 H CH (CH3)CH20C (0)NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0) NHCH3 H CH (CH3)CH20C (0)NHCH3 H CH (CH3)CH20C (0)iNHCH3 H CH (CH3)CH20C (O)NHEt
ch3 cf3 Ph-4-Br ch3 cf3 Ph-4-I ch3 cf3 Ph-4-CF3 ch3 cf3 Ph-4-0CHF2 ch3 cf3 Ph-4-0CF3 ch3 cf3 Ph-4-0CF2Br ch3 cf3 Ph-4-0CF2CHF2 ch3 cf3 Ph-4-0CF2CHFCl ch3 cf3 Ph-4-0CF2CHFCF3 ch3 cf3 Ph-4-0CF2CHF0CF3 ch3 cf3 Ph-4-0CF2CHF0CF2CF2CF3 ch3 cf3 Ph-4-SCH3 · ch3 cf3 Ph-4-S (0&gt; CH3 ch3 cf3 Ph-4-S02CH3 ch3 cf3 Ph-4-SCFa ch3 cf3 Ph+CN ch3 cf3 Ph-3, 4~F2 ch3 cf3 Ph-3-F-4-C1 . ch3 cf3 Ph-3-F-4-CF3 ch3 cf3 Ph-3,4-Cl2 ch3 cf3 Ph-3-Cl-4-0CF3 ch3 cf3 L-46d ch3 Ph~4~F ch3 ch3 Ph+Cl ch3 ch3 Ph-4-Br ch3 ch3 Ph-4-I ch3 ch3 Ph-4-CF3 ch3 ch3 Ph-4-0CHF2 ch3 ch3 Ph+OCF3 ch3 ch3 Ph-4-〇CF 2Br ch3 ch3 Ph-4-0CF2CHF2 ch3 ch3 Ph-4-0CF2CHFCl ch3 ch3 Ph-4-0CF2CHFCF3 ch3 ch3 Ph-4-0CF2CHF0CF: 3 CH3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 CH3 ch3 Ph - 3,4-Cl2 ch3 F cf3 Ph~4^F
254 314918 200407073 Η CH (CH3)CH20C (0) NHEt Cl cf3 Ph-4-CI Η CH (CH3)CH20C (0) NHEt Cl Ph-4-0CF3 ch3 Η CH (CH3)CH20C (0) NHEt Br cf3 Ph+S02CH3 Η CH (CH3)CH20C (0) NHEt ch3 ch3 Ph~4_F Η CH (CH3)CH20C (0) NHEt ch3 Et Ph-4-S02CH3 Η CH (CH3)CH20C (0) NHEt ch3 n-Pr L - 46d Η CH (CH3)CH20C (0) NHEt ch3 i-Pr Ph-4-F Η CH (CH3)CH20C (0) NHEt ch3 chf2 Ph-4-S02CH3 Η CH (CH3)CH20C (0) NHEt ch3 cf3 Cl Η CH (CH3)CH20C (O)NHEt ch3 cf3 ch3 Η CH (CH3)CH2OC (O)NHEt ch3 cf3 och3 Η CH (CH3)CH2OC (O)NHEt ch3 cf3 sch3 ’ Η CH (CH3)CH2OC (0) NHEt ch3 cf3 N(CH3)2 Η CH (CH3)CH2OC (0) NHEt ch3 cf3 Ph-4-F Η CH (CH3)CH2OC (O)NHEt ch3 cf3 Ph-4-Cl Η CH (CH3)CH2OC (O)NHEt ch3 cf3 Ph-4-Br Η CH (CH3)CH2OC (0) NHEt ch3 cf3 Ph+I Η CH (CH3)CH2OC (0) NHEt ch3 cf3 Ph-4-CF3 . Η CH (CH3)CH2OC (0) NHEt ch3 cf3 Ph~4-0CHF2 Η CH (CH3)CH2OC (0) NHEt ch3 cf3 Ph-4-OCFa Η CH (CH3)CH2OC (0) NHEt ch3 cf3 Ph-4-0CF2Br Η CH (CH3)CH2OC (0) NHEt ch3 cf3 Ph-4-0CF2CHF2 Η CH (CH3)CH2OC (0) NHEt ch3 cf3 Ph-4-0CF2CHFCl Η CH (CH3)CH2OC (0) NHEt ch3 cf3 Ph-4-OCF2CHFCF3 Η CH (CH3)CH2OC (0) NHEt ch3 cf3 Ph-4-0CF2CHF0CF3 Η CH (CH3)CH2〇C (0) NHEt ch3 cf3 Ph-4-0CF2CHF0CF2CF2CF3 Η CH (CH3)CH2OC (O)NHEt ch3 cf3 Ph-4-SCH3 Η CH (CH3)CH2OC (O)NHEt ch3 cf3 Ph-4-S (0) CH3 Η CH (CH3)CH2OC (0) NHEt ch3 cf3 Ph-4-S02CH3 Η CH (CH3)CH2OC (0) NHEt ch3 cf3 Ph+SCF3 Η CH (CH3)CH2OC (0) NHEt ch3 cf3 Ph_4_CN Η CH (CH3)CH2OC (0) NHEt ch3 cf3 Ph-3, 4-F 2 Η CH (CH3)CH2OC (0) NHEt ch3 cf3 Ph-3-F_4_C1 Η CH (CH3)CH2OC (0) NHEt ch3 cf3 Ph-3-F-4-CF3 Η CH (CH3)CH2OC (O)NHEt ch3 cf3 Ph-3, 4-Cl2 Η CH (CH3)CH2OC (O)NHEt ch3 cf3 Ph+CH-〇CF3 Η CH (CH3)CH2OC (0) NHEt ch3 cf3 L-14b 255 314918 200407073 Η CH (CH3)CH20C (0) NHEt ch3 cf3 L - 14c Η CH (CH3)CH20C (0) NHEt ch3 cf3 L-14d Η CH (CH3)CH20C (O)NHEt ch3 cf3 L - 14i Η CH (CH3)CH2OC (O)NHEt ch3 cf3 L-14h Η CH (CH3)CH2OC (O)NHEt ch3 cf3 L - 24b Η CH (CH3)CH2OC (0) NHEt ch3 cf3 L-24c Η CH (CH3)CH2OC (0) NHEt ch3 cf3 L - 24e Η CH (CH3)CH2OC (0) NHEt ch3 cf3 L - 36c Η CH (CH3)CH2OC (O)NHEt ch3 cf3 L - 36d Η CH (CH3)CH2OC (0) NHEt ch3 cf3 L-45d Η CH (CH3)CH2OC (O)NHEt ch3 cf3 L-45e Η CH (CH3)CH2OC (0) NHEt ch3 cf3 L - 45g Η CH (CH3)CH2OC (0) NHEt ch3 cf3 L-45m Η CH (CH3)CH2OC (O)NHEt ch3 cf3 L-46d Η CH (CH3)CH2OC (0) NHEt ch3 cf3 L - 46e Η CH (CH3)CH2OC (0) NHEt ch3 cf3 L - 46g Η CH (CH3)CH2OC (0) NHEt ch3 cf3 L - 46j Η CH (CH3)CH2OC (0) NHEt ch3 cf3 L_46k Η CH (CH3)CH2OC (0) NHEt ch3 cf3 L - 46r Η CH (CH3)CH2OC (0) NHEt ch3 CF2Ci L - 46d Η CH (CH3)CH2OC (0) NHEt ch3 cf2cf3 Ph-4~F Η CH (CH3)CH2OC (0).NHEt ch3 Ph-4-F ch3 Η CH (CH3)CH2OC (0) NHEt ch3 Ph-4-Cl ch3 Η CH (CH3)CH20C (O)NHEt ch3 Ph_4-Br ch3 Η CH (CH3)CH2OC (0) NHEt ch3 Ph-4-I ch3 Η CH (CH3)CH20C (0) NHEt ch3 Ph~4_CF 3 ch3 Η CH (CH3)CH2OC (0) NHEt ch3 Ph-4-0CHF2 ch3 Η CH (CH3)CH2OC (O)NHEt ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2OC (0) NHEt ch3 Ph-4-OCF2Br ch3 Η CH (CH3)CH2OC (O)NHEt ch3 Ph-4-0CF2CHF2 ch3 Η CH (CH3)CH2OC (O)NHEt ch3 Ph-4-0CF2CHFCl CH Η CH (CH3)CH2OC (O)NHEt ch3 Ph-4-0CF2CHFCF3 CH Η CH (CH3)CH2OC (0) NHEt ch3 Ph-4-0CF2CHF0CF； 3 CH Η CH (CH3)CH2〇C (O)NHEt ch3 Ph-4_0CF2CHF0CF2CF2CF3 CH Η CH (CH3)CH2OC (O)NHEt ch3 Ph-3, 4_F2 ch3 Η CH (CH3)CH2OC (O)NHEt ch3 Ph-3 - F+Cl ch3 Η CH (CH3)CH2OC (O)NHEt ch3 Ph-3, 4-Cl2 ch3
256 314918 200407073 Η CH (CH3)CH20C (O)NHEt ch3 L - lc ch3 Η CH (CH3)CH2OC (O)NHEt ch3 L~ld ch3 Η CH (CH3)CH2OC (0) NHEt ch3 L-le ch3 Η CH (CH3)CH2OC (0) NHEt ch3 L-li ch3 Η CH (CH3)CH2OC (0) NHEt ch3 L-2b ch3 Η CH (CH3)CH2OC (0) NHEt ch3 L_3d ch3 Η CH (CH3)CH2OC (0) NHEt ch3 L - 3e ch3 Η CH (CH3)CH2〇C (0) NHEt ch3 L-3i ch3 Η CH (CH3)CH2OC (0) NHEt ch3 L-31 ch3 Η CH (CH3)CH2OC (O)NHEt ch3 L - 3o ch3 Η CH (CH3)CH2OC (0) NHEt ch3 L-4c ch3 Η CH (CH3)CH2OC (O)NHPr-n ch3 cf3 Ph_4~F Η CH (CH3)CH2OC (0) NHPr-n ch3 cf3 Ph+Cl Η CH (CH3)CH2OC (0) NHPr-n ch3 cf3 Ph-4-Br Η CH (CH3)CH2OC (0) NHPr-n ch3 cf3 Ph-4-I Η CH (CH3)CH2OC (0) NHPr-n ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2OC (0) NHPr-n ch3 cf3 Ph-4-0CHF2 Η CH (CH3)CH2OC (0) NHPr-n ch3 cf3 Ph-4-OCF 3 , Η CH (CH3)CH20C (0) NHPr-n ch3 cf3 Ph-4-OCFgBr Η CH (CH3)CH2OC (0) NHPr-n ch3 cf3 Ph-4-0CF2CHF2 Η CH (CH3)CH2OC (0) NHPr-n ch3 cf3 Ph-4-0CF2CHFCF Η CH (CH3)CH2OC (0) NHPr-n ch3 cf3 Ph-4-CN Η CH (CH3)CH2OC (0) NHPr-n ch3 cf3 Ph-3, 4-F2 Η CH (CH3)CH2OC (0) NHPr-n ch3 cf3 Ph-3-F-4-Cl Η CH (CH3)CH2OC (0) NHPr-n ch3 cf3 Ph-3, 4-Cl2 Η CH (CH3)CH20C (0) NHPr-n ch3 Ph-4_F ch3 Η CH (CH3)CH2OC (0) NHPr-n ch3 Ph-4-Cl ch3 Η CH (CH3)CH2OC (0) NHPr-n ch3 Ph-4-Br ch3 Η CH (CH3)CH2OC (0) NHPr-n ch3 Ph+CF3 ch3 Η CH (CH3)CH2OC (0) NHPr-n ch3 Ph-4-0CHF2 ch3 Η CH (CH3)CH2OC (0) NHPr-n ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2OC (0) NHPr-n ch3 Ph~4-OCF2Br ch3 Η CH (CH3)CH20C (0) NHPr-n ch3 Ph-4_0CF2CHF2 ch3 Η CH (CH3)CH2OC (0) NHPr-n ch3 Ph-4-0CF2CHFCF3 ch3 Η CH (CH3)CH2OC (0) NHPr-n ch3 Ph-3, 4-Cl2 ch3 Η C，H (CH3)CH20C (O)NHPr-i ch3 cf3 Ph-4-F Η CH (CH3)CH2OC (O)NHPr-i ch3 CF3 Ph-4-C1
257 314918 200407073 Η CH (CH3)CH20C (0) NHPr-i ch3 cf3 Ph - 4*~Br Η CH (CH3)CH20C (0) NHPr-i ch3 cf3 Ph-4-CF3 Η CH (CH3)CH20C (0) NHPr-i ch3 cf3 Ph-4-0CHF2 Η CH (CH3)CH20C (O)NHPr-i ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2OC (0) NHPr-i ch3 cf3 Ph-4-〇CF2Br Η CH (CH3)CH2OC (0) NHPr-i ch3 cf3 Ph-4-0CF2CHF2 Η CH (CH3)CH2OC (0) NHPr-i ch3 cf3 Ph-4-0CF2CHFCF Η CH (CH3)CH2OC (0) NHPr-i ch3 cf3 Ph-4-CN Η CH (CH3)CH2OC (0) NHPr-i ch3 cf3 Ph-3, 4-F2 Η CH (CH3)CH2OC (0) NHPr-i ch3 cf3 Ph-3-F-4-CI Η CH (CH3)CH2OC (0) NHPr~i ch3 cf3 Ph_3,4-Cl2 Η CH (CH3)CH2OC (0) NHPr-i ch3 Ph_4-F ch3 ’ Η CH(CH3)CH20C(0)NHPr-i ' ch3 Ph-4-Cl ch3 Η CH (CH3)CH2OC (0) NHPr-i ch3 Ph-4-Br ch3 Η CH (CH3)CH2OC (0) NHPr~i ch3 Ph-4-CF3 ch3 Η CH (CH3)CH2OC (0) NHPr-i ch3 Ph-4-OCHF2 ch3 Η CH (CH3)CH2OC (0) NHPr-i ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2OC (0) NHPr-i ch3 Ph-4-OCF2Br ch3 . Η CH (CH3)CH2OC (0) NHPr-i ch3 Ph-4-OCF2CHF2 ch3 Η CH (CH3)CH2OC (0) NHPr-i ch3 Ph-4-OCF2CHFCF3 CH3 Η CH (CH3)CH2〇C (0) NHPr-i ch3 Ph-3, 4-Cl 2 ch3 Η CH (CH3)CH2OC (0) NHPr-c ch3 cf3 Ph-4-F Η CH (CH3)CH2OC (0) NHPr-c ch3 cf3 Ph-4-Cl Η CH (CH3)CH2OC (0) NHPr-c ch3 cf3 Ph~4~Br Η CH (CH3)CH2OC (0) NHPr-c ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2OC (0) NHPr-c ch3 cf3 Ph-4-0CHF2 Η CH (CH3)CH2OC (0) NHPr-c ch3 cf3 Ph-4-OCFs Η CH (CH3)CH2OC (0) NHPr-c ch3 cf3 Ph-4-0CF2Br Η CH (CH3)CH2OC (0) NHPr-c ch3 cf3 Ph-4-0CF2CHF2 Η CH (CH3)CH2OC (0) NHPr-c ch3 cf3 Ph-4-0CF2CHFCF Η CH (CH3)CH2OC (0) NHPr-c ch3 cf3 Ph-4-CN Η CH (CH3)CH2OC (0) NHPr-c ch3 cf3 Ph-3, 4-F2 Η CH (CH3)CH2OC (0) NHPr-c ch3 cf3 Ph-3-F-4-C1 Η CH (CH3)CH2OC (0) NHPr~c ch3 cf3 Ph-3, 4~C12 Η CH (CH3)CH2OC (0) NHPr-c ch3 Ph-4-F ch3 Η CH(CH3)CH20C(0)NHPr - c ch3 Ph-4-C1 ch3 Η CH (CH3)CH2OC (0) NHPr-c ch3 Ph~4~Br ch3 258
314918 200407073 H CH (CH3)CH20C (0) NHPr-c H CH (CH3)CH20C (0) NHPr-c H CH (CH3)CH2〇C (0) NHPr-c H CH (CH3)CH20C (0) NHPr-c H CH (CH3)CH20C (0) NHPr-c H CH (CH3)CH20C (0) NHPr-c H CH (CH3)CH20C (0) NHPr-c H CH (CH3)CH20C (0) NHBu-t H CH (CH3)CH20C (0)NHCH2CF3 H CH (CH3)CH20C (0) NHCH2CH20CH3 H CH (CH3)CH20C (0) NHCH2CH2SCH3 H CH (CH3) CH20C (0) NHCH2CH2CH2SCH3 H CH (CH3)CH20C (0) NHCH2CH=CH2 H CH (CH3)CH20C (0) NHCH2Ph H CH (CH3)CH20C (0) NHCH2Ph H CH (CH3)CH20C (0) NHCH2Ph H CH (CH3)CH20C (0) NHCH2Ph H CH (CH3)CH20C (0) NHCH2Ph H CH (CH3)CH20C (0) NHCH2Ph H CH (CH3)CH20C (0) NHCH2Ph H CH (CH3)CH20C (0)NHCH2Ph H CH (CH3)CH20C (0)NHCH2Ph H CH (CH3)CH20C (0) NHCH2Ph H CH (CH3)CH20C (0) NHCH2Ph H CH (CH3)CH20C (0) NHCH2Ph H CH (CH3)CH20C (0) NHCH2Ph H CH (CH3)CH20C (0)NHCH2Ph H CH (CH3)CH20C (0) NHCH2Ph H CH (CH3)CH20C (0) NHCH2Ph H CH (CH3)CH20C (0) NHCH2Ph H CH (CH3)CH20C (0) NHCH2Ph H CH (CH3)CH20C (0)NHCH2Ph H CH(CH3)CH20C (0) NHCH2Ph H CH (CH3)CH20C (0)NHCH2Ph H CH (CH3)CH20C (0)NHCH2Ph H CH (CH3)CH20C (0)NHCH2Ph H CH (CH3)CH20C (0) NHCH2Ph
ch3 Ph+C.F3 ch3 ch3 Ph-4-0CHF2 ch3 ch3 Ph-4-0CF3 ch3 ch3 Ph_4-0CF2Br ch3 ch3 Ph-4-0CF2CHF2 ch3 ch3 Ph-4-0CF2CHFCF3 ch3 ch3 Ph-3,4-Cl2 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-F ch3 cf3 Ph-4-Cl ch3 cf3 Ph-4-Br ch3 cf3 Ph-4-I ch3 cf3 Ph-4：CF3 ch3 cf3 Ph-4-0CHF2 ch3 cf3 Ph-4-0CF3 ch3 cf3 Ph-4-0CF2Br ch3 cf3 Ph-4-0CF2CHF2 ch3 cf3 Ph-4-0CF2CHFCF ch3 cf3 Ph-4-CN ch3 cf3 Ph-3,4-F2 ch3 cf3 Ph-3-F-4-C1 ch3 cf3 Ph&gt;3, 4-CI2 ch3 Ph-4-F ch3 ch3 Ph-4-Cl ch3 ch3 Ph-4-Br ch3 ch3 Ph-4-CF3 ch3 ch3 Ph-4-0CHF2 ch3 ch3 Ph+0CF3 ch3 ch3 Ph-4-0CF2Br ch3 ch3 Ph-4-0CF2CHF2 CH3 ch3 Ph-4-0CF2CHFCF3 ch3 ch3 Ph-3, 4-C12 ch3 259 314918 200407073 Η CH (CH3)CH20C (0) NHCH2 (Ph-4*C1) ch3 cf3 Ph-4-Cl Η CH (CH3) CH20C (0) NHCH2 (Ph-4-0CH3) CH3 Ph-4-0CF3 ch3 Η CH (CH3)CH20C (0) NHCH2(L-46a) ch3 cf3 Ph+Cl Η CH (CH3)CH20C (0) NHCH2(L~47a) ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH20C (0) NHPh ch3 cf3 Ph_4_F Η CH (CH3)CH20C (0) NHPh ch3 cf3 Ph+Cl Η CH (CH3)CH20C (0) NHPh ch3 cf3 Ph-4-Br Η CH (CH3)CH20C (0) NHPh ch3 cf3 Ph-4-I Η CH (CH3)CH20C (O)NHPh ch3 cf3 Ph+CF3 Η CH (CH3)CH2OC (0) NHPh ch3 cf3 Ph-4-0CHF2 Η CH (CH3)CH2OC (0) NHPh ch3 cf3 Ph-4_0CF3 Η CH (CH3)CH2OC (0) NHPh ch3 cf3 Ph-4-0CF2Br Η CH (CH3)CH2OC (0) NHPh ch3 cf3 Ph-4-0CF2CHF2 Η CH (CH3)CH2OC (0) NHPh ch3 cf3 Ph-4-0CF2CHFCF Η CH (CH3)CH2OC (0) NHPh ch3 cf3 Ph-4-CN Η CH (CH3)CH2OC (0) NHPh ch3 cf3 Ph-3, 4-F2 Η CH (CH3)CH2OC (0) NHPh ch3 cf3 Ph-3-F-4-C1 Η CH (CH3)CH2OC (0) NHPh ch3 cf3 Ph-3,4-Cl2 Η CH (CH3)CH2OC (0) NHPh ch3 Ph-4-F ch3 Η CH (CH3)CH2OC (0) NHPh ch3 Ph-4-Cl ch3 Η CH (CH3)CH2OC (0) NHPh ch3 Ph-4-Br ch3 Η CH (CH3)CH2〇C (0) NHPh ch3 Ph-4-CF3 ch3 Η CH (CH3)CH20C (0) NHPh ch3 Ph-4-0CHF2 ch3 Η CH (CH3)CH2OC (0) NHPh ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2OC (0) NHPh ch3 Ph-4-0CF2Br ch3 Η CH (CH3)CH2OC (0) NHPh ch3 Ph-4_0CF2CHF2 ch3 Η CH (CH3)CH2OC (0) NHPh ch3 Ph-4-OCF2CHFCF3 CH3 Η CH (CH3)CH2OC (0) NHPh ch3 Ph-3, 4~C12 ch3 Η CH(CH3)CH2OC (0)N(CH3) 2 ch3 cf3 Ph-4-Cl Η CH (CH3)CH2OC (O)N(Et) 2 CHa cf3 Ph-4-F Η CH (CH3)CH2OC (0)N(Et)2 ch3 cf3 Ph-4-Cl Η CH (CH3)CH2OC (O)N(Et) 2 ch3 cf3 Ph+Br Η CH (CH3)CH2OC (O)N(Et) 2 ch3 cf3 Ph-4-I Η CH (CH3)CH2OC (0)N(Et)2 ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2OC (0)N(Et)2 ch3 cf3 Ph-4-0CHF2 Η CH (CH3)CH20C (0)N(Et)2 ch3 cf3 Ph-4-0CF3 Η CH (GH3)CH20C(0)N(Et)2 ch3 cf3 Ph-4-0CF2Br
260 314918 200407073 Η CH(CH3)CH20C (O)N(Et) 2 ch3 cf3 Ph-4-0CF2CHF2 Η CH (CH3)CH2OC (O)N(Et) 2 ch3 cf3 Ph-4-0CF2CHFCF Η CH (CH3)CH2OC (O)N(Et) 2 ch3 cf3 Ph-4-CN Η CH (CH3)CH2OC (O)N(Et) 2 ch3 cf3 Ph-3, 4-F2 Η CH (CH3)CH2OC (0)N(Et)2 ch3 cf3 Ph-3-F-4-Cl Η CH (CH3)CH2OC (O)N(Et) 2 ch3 cf3 Ph-3,4-Cl2 Η CH (CH3)CH2OC (O)N(Et) 2 ch3 Ph-4_F ch3 Η CH (CH3)CH2OC (O)N(Et) 2 ch3 Ph-4-Cl ch3 Η CH (CH3)CH2OC (O)N(Et) 2 ch3 Ph-4-Br ch3 Η CH (CH3)CH2OC (O)N(Et) 2 ch3 Ph-4-CF3 ch3 Η CH (CH3)CH2OC (0)N(Et)2 ch3 Ph-4-0CHF2 ch3 Η CH (CH3)CH2OC (O)N(Et) 2 ch3 Ph-4-0CF3 ch3 ‘ Η CH (CH3)CH2OC (0)N(Et)2 ch3 Ph-4-0CF2Br ch3 Η CH (CH3)CH2OC (0)N(Et)2 ch3 Ph-4-0CF2CHF2 ch3 Η CH (CH3)CH2OC (0)N(Et)2 ch3 Ph-4-OCF2CHFCF3 CH3 Η CH (CH3)CH2OC (O)N(Et) 2 ch3 Ph-3, 4-Cl2 ch3 Η CH (CH3)CH2OC (0)N(Pr-i)2 ch3 cf3 Ph-4-C1 Η CH (CH3)CH2OC (0)N(CH3)Ph ch3 Ph-4-0CF3 ch3 . Η CH(CH3)CH20C(0) (T-16) ch3 cf3 Ph-4-Cl Η CH(CH3)CH20C(0) (T-19) ch3 Ph+OCF3 ch3 Η CH(CH3)CH20C(0) (T-20) ch3 cf3 Ph-4-C1 Η CH(CH3)CH20C(0) (T-21) ch3 Ph-4-OCF3 ch3 Η CH(CH3)CH20P(0) (OEt) 2 ch3 cf3 Ph-4-Cl Η CH(CH3)CH2〇P(S) (OCH3) 2 ch3 cf3 Ph~4~F Η CH(CH3)CH2OP ⑸（0CH3) 2 ch3 cf3 Ph-4-Cl Η CH(CH3)CH2OP(S) (OCH3) 2 ch3 cf3 Ph-4-Br Η CH(CH3)CH2OP(S) (OCH3) 2 ch3 cf3 Ph-4-I Η CH(CH3)CH2OP(S) (OCH3) 2 ch3 cf3 Ph-4-CF3 Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 cf3 Ph-4-OCHF2 Η CH(CH3)CH2OP(S) (OCH3) 2 ch3 cf3 Ph-4-0CF3 Η CH(CH3)CH2OP(S) (OCH3) 2 ch3 cf3 Ph-4-0CF2Br Η CH(CH3)CH2OP(S) (OCH3) 2 ch3 cf3 Ph-4-0CF2CHF2 Η CH(CH3)CH2OP(S) (OCH3) 2 ch3 cf3 Ph-4-0CF2CHFCF, Η CH(CH3)CH2OP(S) (OCH3) 2 ch3 cf3 Ph-4-CN Η CH(CH3)CH2OP(S) (OCH3) 2 ch3 cf3 Ph-3,4-F2 Η CH(CH3)CH2OP(S) (〇ch3) 2 ch3 cf3 Ph-3-F-4-C1 Η CH(CH3)CH20P(S) (OCH3) 2 ch3 cf3 Ph-3, 4-Cl2
261 314918 200407073 Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph_4~F ch3 Η CH(CH3)CH20P(S) (0CH3) 2 ch3 Ph-4-Cl ch3 Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph~4~Br ch3 Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph+CF3 ch3 Η CH(CH3)CH20P(S) (0CH3) 2 ch3 Ph-4-0CHF2 ch3 Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph-4-0CF3 ch3 Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph~4-0CF2Br ch3 Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph-4-0CF2CHF2 ch3 Η CH(CH3)CH20P(S) (0CH3) 2 ch3 Ph-4-0CF2CHFCF3 CH3 Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph-3, 4-Cl2 ch3 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-4-F Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-4-Cl Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph~4~Br Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-4-I Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-4-CF3 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-4-OCHF2 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-4-0CF3 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-4-0CF2Br . Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-4_0CF2CHF2 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-4-0CF2CHFCF Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-4-CN Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-3, 4-F2 Η CH(CH3)CH20P(S) (OEt) 2 ch3 cf3 Ph-3-F-4-Cl Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-3, 4-Cl2 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph-4-F ch3 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph-4-Cl ch3 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph-4-Br ch3 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph-4-CF3 ch3 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph-4-0CHF2 ch3 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph-4-0CF3 ch3 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph~4~0CF 2Br ch3 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph-4-OCF2CHF2 ch3 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 PIHK)CF2CHFCF3 ch3 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph-3, 4-Cl2 ch3 Η CH (CH3)CH2OPh ch3 cf3 Ph-4-Cl Η CH(CH3)CH20(Ph-4-C1) ch3 cf3 Ph-4-F Η CH (CH3)CH20(Ph-4-Cl) ch3 cf3 Ph-4-Cl
262 314918 200407073 Η CH(CH3)CH20(Ph+Cl) ch3 cf3 Ph-4-0S02CH3 Η CH (CH3)CH20(Ph-4-Cl) ch3 cf3 PM - SCH3 Η CH (CH3)CH20(Ph-4-Cl) ch3 cf3 Ph+S(0)CH3 Η CH(CH3)CH20(Ph-4 - Cl) ch3 cf3 Ph-4-S02CH3 Η CH (CH3)CH20(Ph-4-Cl) ch3 cf3 Ph-4-CN Η CH(CH3)CH20(Ph+Cl) ch3 Ph-4-F ch3 Η CH (CH3)CH20(Ph-4-Cl) ch3 Ph-4-Cl ch3 Η CH(CH3)CH20(Ph-4 - Cl) ch3 Ph~4~Br ch3 Η CH (CH3)CH20(Ph-4-Cl) ch3 Ph-4-CF3 ch3 Η CH (CH3)CH20(Ph-4-Cl) ch3 Ph-4-0CHF2 ch3 Η CH(CH3)CH20(Ph+Cl) ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH20(Ph-4-Cl) ch3 Ph-4-0S02CH3 ch3 Η CH (CH3)CH20(Ph-4-Cl) ch3 Ph+SCH3 ch3 Η CH(C.H3)CH20(Ph - 4-Cl) ch3 Ph-4-S (0) CH3 ch3 Η CH(CH3)CH20(Ph - 4-C1) ch3 Ph-4-S02CH3 ch3 Η CH (CH3)CH20(Ph-4-Cl) ch3 Ph-4-CN ch3 Η CH (CH3)CH20(Ph-3-CF3) ch3 cf3 Ph-4-Cl Η CH (CH3)CH20(Ph-3-CF3) ch3 Ph-4_0CF3 ch3 . Η CH (Et)CH20H ch3 cf3 Ph-4-Cl Η CH (Et)CH20H ch3 Ph-4-0CF3 ch3 Η CH (Et)CH20CH3 ch3 cf3 Ph-4-Cl Η CH (Ph) CH20H ch3 Ph-4_0CF3 ch3 Η CH (Ph) CH20H (R) ch3 cf3 Ph-4-Cl Η CH (Ph-2-Cl)CH20H ch3 Ph-4-0CF3 ch3 Η CH (Ph-4-Cl)CH20H ch3 cf3 Ph-4-C1 Η CH (Ph-4-Ph) CH20H ch3 Ph-4-0CF3 ch3 Η c(ch3)2ch2oh ch3 cf3 Ph-4-Cl Η c(ch3)2ch2och3 ch3 cf3 Ph-4-F Η c(ch3)2ch2och3 ch3 cf3 Ph+Cl Η c(ch3)2ch2och3 ch3 cf3 Ph-4-Br Η c(ch3)2ch2och3 ch3 cf3 Ph-4] Η C(CH3)2CH20CH3 ch3 cf3 Ph+CF3 Η C(CH3) 2ch2och3 ch3 cf3 Ph-4-0CHF2 Η C(CH3)2CH20CH3 ch3 cf3 Ph-4-0CF3 Η c(ch3)2ch2och3 ch3 cf3 Ph-4-0CF2Br Η c(ch3) 2ch2och3 ch3 cf3 Ph-4-0CF2CHF2 Η C(CH3) 2ch2och3 ch3 cf3 Ph-4-0CF2CHFCl
263 314918 200407073 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3)2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3)2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3)2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C (CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3)2CH20CH3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3
CH3 Ph_4-F CH3 Ph-4-Cl CH3 Pli - 4-Br
CH3 Ph-4-I CH3 Ph+CF3 CH3 Ph-4-0CHF2 CH3 Ph-4_0CF3 CH3 ch3 ch3 ch3 ch3 ch3 ch3 ch3
Ph-4-0CF2CHFCF3 Ph-4-0CF2CHF0CF3 Ph-4-0CF2CHF0CF2CF2CF Ph-4-0S02CH3 Ph-4-SCHs Ph-4 - S(0)CH3 Ph+S02CH3 Ph-4-SEt Ph-4-S02Et Ph-4-SPr-i Ph-4-S02Pr-i Ph-4-N02 ' Ph-4-CN Ph-4-C (0) NH2 Pb-4-C ⑸ NH2 Ph-3, 4-F2 Ph-3-F-4-Cl Ph-3,4-Cl2 . L - 46d L-46e L-46f L - 46g CH3 ch3 ch3 ch3 ch3 ch3 ch3
Ph-4-0CF2Br CH3 Ph-4_0CF2CHF2 CH3 Ph-4-0CF2CHFCl CH3 Ph-4-0CF2CHFCF3 CH3 Ph-4_0CF2CHF0CF3CH3 Ph-4_0CF2CHF0CF2CF2CF3 CH3 Ph-4-CN CH3 Ph-3,4-Cl2 CH3 264 314918 200407073 Η C(CH3) 2ch2oc (0) ch3 ch3 cf3 Ph-4-Cl Η C(CH3) 2CH20C (0) cf3 ch3 Ph-4-0CF3 CHa Η C(CH3) 2CH20C (0)NHCH3 F cf3 Ph+Cl Η C(CH3) 2CH20C (0)NHCH3 Cl cf3 Ph-4-S02CH3 Η C(CH3) 2CH20C (0) nhch3 Cl Ph-4-0CF3 ch3 Η C(CH3) 2ch2oc (0)NHCH3 Br CFs Ph-4-F Η C(CH3) 2CH20C (0)NHCH3 ch3 ch3 L-46d Η C(CH3) 2CH20C (0)NHCH3 ch3 Et Ph_4-F Η C(CH3) 2ch2oc (0)NHCH3 ch3 n-Pr Ph-4-S02CH3 Η c(ch3) 2ch2oc(o)nhch3 ch3 i - Pr L-46d Η c(ch3) 2ch2oc(o)nhch3 ch3 chf2 Ph-4-F Η C(CH3) 2CH20C (0) nhch3 ch3 cf3 Cl 1 Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 ch3 Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 och3 Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 sch3 Η C(CH3) 2ch2oc (0)NHCH3 ch3 cf3 N(CH3) 2 Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 Ph_4-F Η c(ch3) 2ch2oc(o)nhch3 ch3 cf3 Ph-4：C1 Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 Ph-4-Br Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 Ph-4-1 Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 Ph-4-CF3 Η C (CH3) 2ch2oc (0)NHCH3 ch3 cf3 Ph-4-0CHF2 Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 Ph-4*-0CF3 Η c(ch3) 2ch2oc(o)nhch3 ch3 cf3 Ph-4-0CF2Br Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 Ph-4-0CF2CHF2 Η c(ch3) 2ch2oc(o)nhch3 ch3 cf3 Ph-4-0CF2CHFCl Η C(CH3) 2CH20C (0) nhch3 ch3 cf3 Ph-4-0CF2CHFCF3 Η C(CH3) 2ch2oc (0)NHCH3 ch3 cf3 Ph-4-0CF2CHF0CF3 Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 Ph-4-0CF2CHF0CF2CF2CF Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 Ph+SCH3 Η C(CH3) 2ch2oc (0)NHCH3 ch3 cf3 Ph-4-S (0) CH3 Η C(CH3) 2CH20C (0) nhch3 ch3 cf3 Ph+S02CH3 Η c(ch3) 2ch2oc(o)nhch3 ch3 cf3 Ph-4-SCF3 Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 Ph-4-N02 Η c(ch3) 2ch2oc(o)nhch3 ch3 CFs Ph - 4-CNT Η c(ch3) 2ch2oc(o)nhch3 ch3 cf3 Ph-4-C (0)NH2
265 314918 200407073 Η C(CH3) 2ch2oc (0)NHCH3 ch3 cf3 Ph-4-C (S)NH2 Η C(CH3) 2CH20C (0) nhch3 ch3 cf3 Ph-3,4-F2 Η C(CH3) 2CH20C (0) nhch3 ch3 cf3 Ph-3 -F+Cl Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 Ph-3-F-4-CF3 Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 Ph-3, 4-Cl 2 Η C(CH3) 2CH20C (0) NHCHs ch3 cf3 Ph+CH-OCF Η C(CH3) 2CH20C (0) NHCHa ch3 cf3 L-14b Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 L - 14c Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 L-14d Η C(CH3) 2CH20C (0) NHCHs ch3 cf3 L-14f Η C(CH3) 2CH20C (0) NHCHs ch3 cf3 L-14h Η C(CH3) 2CH20C (0) nhch3 ch3 cf3 L - 24b Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 L-24c Η c(ch3) 2ch2oc(o)nhch3 ch3 cf3 L - 24e Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 L-36c Η c(ch3) 2ch2oc(o)nhch3 ch3 cf3 L-36d Η C(CH3) 2CH20C (0) nhch3 ch3 cf3 L - 45d Η C(CH3) 2CH20C (0) nhch3 ch3 cf3 L-45e . Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 L - 45g Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 L-45m Η C(CH3) 2CH20C (0) nhch3 ch3 cf3 L - 46d Η C(CH3) 2CH20C (0) NHCHs ch3 cf3 L-46e Η C(CH3) 2CH20C (0) nhch3 ch3 cf3 L-46g Η c(ch3) 2ch2oc(o)nhch3 ch3 cf3 L - 46j Η C(CH3) 2CH20C (0)NHCH3 ch3 cf3 L - 46k Η C(CH3) 2CH20C (0) nhch3 ch3 cf3 L - 46r Η C(CH3) 2CH20C (0) NHCHa ch3 cf2ci Ph-4-S02CH3 Η C(CH3) 2CH20C (0) nhch3 ch3 cf2cf3 L - 46d Η C(CH3) 2CH20C (0)NHCH3 ch3 Ph-4~F ch3 Η c(ch3) 2ch2oc(o)nhch3 ch3 Ph-4-Cl ch3 Η C(CH3) 2CH20C (0) nhch3 ch3 Ph_4-Br ch3 Η C(CH3) 2CH20C (0)NHCH3 ch3 Ph+I ch3 Η C(CH3) 2CH20C (0)NHCH3 ch3 Ph-4-CF3 ch3 Η C(CH3) 2ch2oc (0)NHCH3 ch3 Ph-4-0CHF2 ch3 Η C(CH3) 2CH20C (0) nhch3 ch3 Ph-4-0CF3 ch3 Η C(CH3) 2CH20C (0) nhch3 ch3 Ph-4~0CF2Br ch3 Η C(CH3) 2CH20C (0) NHCHa ch3 Ph-4-0CF2CHF2 ch3
266 314918 200407073 H C(CH3) 2CH20C (0) nhch3 H C(CH3) 2CH20C (0) nhch3 H C(CH3) 2CH20C (0) nhch3 H C(CH3) 2CH20C (0)NHCH3 h c(ch3) 2ch2oc(o)nhch3 H C(CH3) 2CH20C (0)NHCH3 H C(CH3) 2CH20C (0)NHCH3 H C(CH3) 2CH20C (0)NHCH3 h c(ch3) 2ch2oc(o)nhch3 H C(CH3) 2CH20C (0) nhch3 H C(CH3) 2CH20C (0) nhch3 H C(CH3) 2CH20C (0) nhch3 H C(CH3) 2CH20C (0)NHCH3 H C(CH3) 2CH20C (0) nhch3 H C(CH3) 2CH20C (0) nhch3 H C(CH3) 2ch2oc (0)NHCH3 H C(CH3) 2CH20C (0) NHCHs H C(CH3) 2CH20C (0) nhch3 H C(CH3) 2CH20C (0) nhch3 H C(CH3) 2CH20C (0) NHEt H C(CH3) 2CH20C (O)NHEt H C(CH3) 2CH2OC (O)NHEt H C(CH3) 2CH2OC (O)NHEt H C(CH3) 2CH2OC (O)NHEt H C(CH3) 2CH2OC (O)NHEt H C(CH3) 2CH2OC (0) NHEt H C(CH3) 2CH2OC (0) NHEt H C(CH3) 2CH2OC (0) NHEt H C(CH3) 2CH2OC (O)NHEt H C(CH3)2CH2OC (O)NHEt H C(CH3)2CH2OC (O)NHEt H C(CH3) 2CH2OC (O)NHEt H C(CH3)2CH2OC (O)NHEt H C(CH3) 2CH2OC (0) NHEt H C(CH3) 2CH2OC (O)NHEt H C(CH3) 2CH2OC (O)NHEt H C(CH3) 2CH2OC (O)NHEt ch3 Ph-4-0CF2CHFC1 ch3 Ph-4-0CF2CHFCF3 ch3 Ph-4-OCF2CHFOCF ch3 Ph-4-0CF2CHF0CF ch3 Ph_4-CN ch3 Ph-3, 4-F2 ch3 Ph-3-F-4-Cl ch3 Ph-3, 4-Cl2 ch3 L_]c ch3 L-ld ch3 L - le ch3 L-li ch3 L - 2b ch3 L - 3d ch3 L-3e ch3 L-3f ch3 L-31 ch3 L-3o ch3 L - 4c ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 ch3 ch3 cf2cf3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3. ch3
Ph-4-F Ph-4-C1 Ph-4-Br Ph+I Ph-4-CF3 Ph-4-0CHF2 Ph-4-OCF3 Ph-4-0CF2Br Ph-4OCF2CHF2 Ph-4-0CF2CHFCl Ph-4OCF2CHFCF3 Ph-4-0CF2CHF0CF3 Ph-4_0CF2CHF0CF2CF2CF3 Ph-4-SCH3 Ph-4-S (0) CH3 Ph-4-S02CH3 PlHl-SCF3 Ph~4_N02
267 314918 200407073 Η C(CH3) 2CH20C (0) NHEt ch3 cf3 Ph-4-CN Η C(CH3) 2CH20C (0) NHEt ch3 cf3 Ph-3, 4-F 2 Η C(CH3) 2CH20C (0) NHEt ch3 cf3 Ph-3-F-4-Cl Η C(CH3) ,CH20C (O)NHEt ch3 cf3 Ph-3-F-4-CF3 Η C(CH3) 2CH20C (0) NHEt ch3 cf3 Ph-3,4-Cl2 Η C(CH3) 2CH20C (0) NHEt ch3 cf3 Ph-3-Cl-4-0CF3 Η C(CH3) 2CH2OC (0) NHEt ch3 cf3 L-46d Η C(CH3) 2CH2OC (O)NHEt ch3 Ph-4-F ch3 Η C(CH3) 2CH2OC (O)NHEt ch3 Ph-4-Cl ch3 Η C(CH3) 2CH20C (O)NHEt ch3 Ph-4-Br ch3 Η C(CH3) 2CH2OC (O)NHEt ch3 Ph~4~*I ch3 Η C(CH3) 2CH2OC (O)NHEt ch3 Ph-4-CF3 ch3 Η C(CH3) 2CH2OC (O)NHEt ch3 Ph+OCHF2 ch3 Η C(CH3) 2CH2OC (0) NHEt ch3 Ph-4-0CF3 ch3 Η C(CH3) 2CH20C (0) NHEt ch3 Ph-4-0CF2Br ch3 Η C(CH3) 2CH2OC (0) NHEt ch3 Ph-4-0CF2CHF2 ch3 Η C(CH3) 2CH2OC (0) NHEt ch3 Ph-4-0CF2CHFCl ch3 Η C(CH3)2CH2OC (0) NHEt ch3 Ph-4-0CF2CHFCF3 ch3. Η C(CH3) 2CH2OC (0) NHEt ch3 Ph-4-0CF2CHF0CF3 CH3 Η C(CH3) 2CH2OC (0) NHEt ch3 Ph_4-0CF2CHF0CF2CF2CF3CH3 Η C(CH3) 2CH2OC (0) NHEt ch3 Ph-3, 4-F2 ch3 Η C(CH3) 2CH2OC (0) NHEt ch3 Ph-3-F-4-Cl ch3 Η C(CH3) 2CH2OC (0) NHEt ch3 Ph - 3,4-Cl2 ch3 Η C(CH3) 2CH2OC (O)NHPr-n ch3 cf3 Ph-4-F Η C(CH3) 2CH2OC (0) NHPr-n ch3 cf3 Ph-4-Cl Η C(CH3) 2CH2OC (0) NHPr-n ch3 cf3 Ph-4-Br Η C(CH3)2CH2OC (O)NHPr-n ch3 cf3 Ph-4-1 Η C(CH3) 2CH2OC (0) NHPr-n ch3 cf3 Ph-4-CF3 Η C(CH3) 2CH20C(0)NHPr-n ch3 cf3 Ph-4-OCHF2 Η C(CH3) 2CH2OC (0)NHPr-n ch3 cf3 Ph-4-0CF3 Η C(CH3) 2CH2OC (0) NHPr-n ch3 cf3 Ph-4-OCF2Br Η C(CH3) 2CH2OC (0) NHPr-n ch3 cf3 Ph-4-0CF2CHF2 Η C(CH3) 2CH2OC (0)NHPr-n ch3 cf3 Ph-4-0CF2CHFCF Η C(CH3) 2CH2OC (0) NHPr-n ch3 cf3 Ph+CN Η C(CH3) 2CH2OC (0) NHPr-n ch3 cf3 Ph - 3,4-F2 Η C(CH3) 2CH2OC (0)NHPr-n ch3 cf3 Ph-3-F-4-Cl Η C(GH3) 2CH2OC (0) NHPr-n ch3 cf3 Ph_3, 4-C12
268 314918 200407073 H C(CH3) 2CH20C (O)NHPr-n H C(CH3) 2CH2OC (0) NHPr-n H C(CH3) 2CH2OC (0) NHPr-n H C(CH3) 2CH2OC (0) NHPr-n H C(CH3) 2CH2OC (0) NHPr-n H C(CH3) 2CH2OC (0) NHPr-n H C(CH3) 2CH2OC (0) NHPr-n H C(CH3) 2CH2OC (0) NHPr-n H C(CH3) 2CH2OC (0) NHPr-n H C(CH3) 2CH2OC (0) NHPr-i H C(CH3) 2CH2OC (0) NHPr-c H C(CH3) 2ch2oc (0)NHCH2CF3 H C(CH3) 2CH2OC (0) NHCH2CH2OCH3 H C(CH3) 2CH2OC (0) nhch2ch2sch3 H C(CH3) 2CH2OC (0) nhch2ch2ch2sch3 H C(CH3) 2CH2OC (0)NHCH2CH=CH, H C(CH3) 2CH2OC (0) NHCH2Ph H C(CH3) 2CH2OC (0) NHCH2Ph H C(CH3) 2CH20C(0)NHCH2Ph H C(CH3) 2CH2OC (0)NHCH2Ph H C(CH3) 2CH2OC (0)NHCH2Ph H C(CH3) 2CH2OC (0)NHCH2Ph H C(CH3) 2CH2OC (0)NHCH2Ph H C(CH3) 2CH2OC (0)NHCH2Ph H C(CH3) 2CH2OC (0) NHCH2Ph H C(CH3) 2CH2OC (0)NHCH2Ph H C(CH3) 2CH2OC (0)NHCH2Ph H C(CH3) 2CH2OC (0)NHCH2Ph H C(CH3) 2CH20C(0)NHCH2Ph H C(CH3) 2CH2OC (0)NHCH2Ph H C(CH3) 2CH2OC (0) NHCH2Ph H C(CH3) 2CH2OC (0)NHCH2Ph H C(CH3) 2CH2OC (0)NHCH2Ph H C(CH3) 2CH2OC (0) NHCH2Ph H C(CH3) 2CH2OC (0) NHCH2Ph H C(CH3) 2CH2OC (0)NHCH2Ph
ch3 Ph~4~F ch3 ch3 Ph+Cl ch3 ch3 Ph-4-Br ch3 ch3 Ph-4-I ch3 ch3 Ph-4-CF3 ch3 ch3 Ph-4_0CHF2 ch3 ch3 Ph-4-0CF3 ch3 ch3 Ph~4~0CF2Br ch3 ch3 Ph-3, 4-Cl2 ch3 ch3 cf3 Ph-4-Cl ch3 Ph_4-OCF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4_0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4_0CF3 ch3 ch3 cf3 Ph-4-C1 ch3 cf3 Ph-4-F ch3 cf3 Ph - 4.-C1 ch3 cf3 Ph_4-Br ch3 cf3 Ph-4-I ch3 cf3 Ph-4-CF3 ch3 cf3 Ph-4-OCHF2 ch3 cf3 Ph-4-0CF3 ch3 cf3 Ph-4-0CF2Br ch3 cf3 Ph-4~0CF2CHF2 ch3 cf3 Ph-4-OCF2CHFCF ch3 cf3 Ph-4-SCH3 ch3 cf3 Ph-4-S02CH3 ch3 cf3 Ph-4-CN ch3 cf3 Ph-3, 4-F 2 ch3 cf3 Ph-3-F-4-Cl ch3 cf3 Ph_3, 4-Cl 2 ch3 Ph-4-F ch3 ch3 Ph-4-Cl ch3 ch3 Ph-4-Br ch3 ch3 Ph-4-I ch3 269 314918 200407073 ch3 Ph+CF3 ch3 Ph-4-0CHF2 ch3 Ph-4-OCFs ch3 Ph-4_0CF2Br ch3 Ph-4-SCH3 ch3 Ph-4-S02CH3 ch3 Ph+CN ch3 Ph-3, 4-Cl2 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 Ph+F ch3 Ph-4-Cl ch3 Ph+Br ch3 Ph-4-I ch3 Ph-4-CF3 ch3 Ph-4-0CHF2 ch3 Ph-4-OCF3 ch3 Ph - tOCFgBr ch3 Ph-4-0CF2CHF2 ch3 Ph-4-0CF2CHFCF3 ch3 Ph-4-0CF2CHF0CF ch3 Ph-3,4-Cl2 ch3 cf3 270 H C(CH3)2CH20C (0)NHCH2Ph H C(CH3) 2CH20C(0)NHCH2Ph H C(CH3) 2CH20C (0)NHCH2Ph H C(CH3) 2CH20C (0)NHCH2Ph H C(CH3) 2CH20C (0)NHCH2Ph H C(CH3) 2CH20C (0)NHCH2Ph H C(CH3) 2CH20C(0)NHCH2Ph H C(CH3) 2CH20C (0) NHCH2Ph H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2〇H2OC (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3) 2CH20C (0)N(CH3) 2 H C(CH3&gt; 2CH20P ⑸（0CH3) 2 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3
Ph，4-F Ph-4-Cl Ph-4_Br
Ph-4-ί φ
Ph-4-CF 3
Ph-4_0CHF2
Ph-4-OCF 3
Ph-4-0CF2Br
Ph-4-0CF2CHF2
Ph-4r〇CF2CHFCF3
Ph-4-SCH3
Ph-4-S02CH3
Ph-4-CN
Ph-3, 4-F2
Ph-3HF-4-Cl
Ph-3,4-Cl2 _ ch3 零 CH3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3
Ph-4-Cl 314918 200407073 H CH2CH2CH20H Η CH2CH2CH2OCH3 Η CH (CH3)CH2CH2OCH3 H CH (CH3)CH2CH20CH3 H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH20Et H CH (CH3)CH2CH20Et H CH (CH3)CH2CH20Et H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH20Et H CH (CH3)CH2CH20Et H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH20Et H CH (CH3)CH2CH20Et H CH (CH3)CH2CH20Et H CH (CH3)CH2CH20Et H CH (CH3)CH2CH20Et H CH (CH3)CH2CH20Et H CH (CH3)CH2CH20Et H CH (CH3)CH2CH20Et H CH (CH3)CH2CH20Et H CH (CH3)CH2CH20Et H CH (CH3)CH2CH20Et H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH20Et H CH (CH3)CH2CH20Et H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH2OEt ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 cf3 Ph-4-CI ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-F ch3 cf3 Ph-4-Cl ch3 cf3 Ph-4-Br ch3 cf3 Ph+l ch3 cf3 Ph-4-CF 3 ch3 cf3 Ph-4-0CHF2 ch3 cf3 Ph-4-0CF3 ch3 cf3 Ph-4-0CF2Br ch3 cf3 Ph-4-0CF2CHF2 ch3 cf3 Ph-4-0CF2CHFCF ch3 cf3 Ph_4_0S02CH3 ch3 cf3 Ph-4-SCH3 ch3 cf3 Ph-4-S (0&gt; CH3 ch3 cf3 Ph-4rS02CH3 ch3 cf3 Ph-4-SCF3 ch3 cf3 Ph-4-NO2 ch3 cf3 Ph+CN ch3 cf3 Ph-3, 4-F2 ch3 cf3 Ph-3-F-4-Cl ch3 cf3 Ph-3, 4-Cl2 ch3 cf3 L-46d ch3 cf3 L - 47a ch3 Ph-4-F ch3 ch3 Ph-4-Cl ch3 ch3 Ph-4-Br ch3 ch3 Ph-4-I ch3 ch3 Ph-4-CF3 ch3 ch3 Ph-4-0CHF2 ch3 ch3 Ph-4-0CF3 ch3 ch3 Ph_4_0CF2Br ch3 ch3 Ph-4-0CF2CHF2 ch3 ch3 Ph-4-0CF2CHFCF3 ch3 ch3 Ph-4-0CF2CHF0CF· 3 ch3
271 314918 200407073 H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH2OPr-n H CH (CH3)CH2CH2OBu-i H CH (CH3)CH2CH2OCH2CF3 H CH (CH3)CH2CH2OCH2CH2OCH3 H CH (CH3)CH2CH20C (0) NHEt H CH2CH2CH2CH2OC (0) NHEt H CH2CH2CH2CH20C (0) NHPr-i H CH2CH2CH2CH2CH20C (0) NHEt Η T-10 H M-4a H M-5a H CH2 (M-7a) H CH2 (M-16a) -CH2CH20CH2CH2-H CH2SCH3 H CH2CH2SCH3 H CH2CH2Set H CH2CH2SPr-i H CH2CH (CH3)SCH3 H CH2CH (CH3)S02CH3 H CH2CH (CH3)SEt H CH2CH (CH3)S02Et
H CH (CH3)CH2SH H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3
ch3 Ph-3, 4-F2 ch3 ch3 Ph-3-F4-Cl ch3 ch3 Ph-3,4-Cl2 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-OCFs ch3 ch3 cf3 Ph-4-Cl ch3 Ph&gt;4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-C1 ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl F cf3 Ph一4一f F cf3 PlHhCl F cf3 Ph-4-Br F cf3 Ph-4-OCFs F Ph-4-0CF3 ch3 Cl cf3 Ph~4~F Cl cf3 Ph_4_Cl Cl cf3 Ph-4-Br Cl cf3 Ph-4-CF3 Cl cf3 Ph-4-OCHF Cl cf3 Ph-4-0CF3 272 314918 200407073 Η CH (CH3)CH2SCH3 Cl Η CH (CH3)CH2SCH3 Cl Η CH (CH3)CH2SCH3 Cl Η CH (CH3)CH2SCH3 Cl Η CH (CH3)CH2SCH3 Cl Η CH (CH3)CH2SCH3 Cl Η CH (CH3)CH2SCH3 Cl Η CH (CH3)CH2SCH3 Cl Η CH (CH3)CH2SCH3 Br Η CH (CH3)CH2SCH3 Br Η CH (CH3)CH2SCH3 Br Η CH (CH3)CH2SCH3 Br Η CH (CH3)CH2SCH3 Br Η CH (CH3)CH2SCH3 CH： Η CH (CH3)CH2SCH3 CH： Η CH (CH3)CH2SCH3 CH： Η CH (CH3)CH2SCH3 CH： Η CH (CH3)CH2SCH3 CH： Η CH (CH3)CH2SCH3 CH： Η CH (CH3)CH2SCH3 CH： Η CH (CH3)CH2SCH3 CH, Η CH (CH3)CH2SCH3 CH： Η CH (CH3)CH2SCH3 CH： Η CH (CH3)CH2SCH3 CH, Η CH (CH3)CH2SCH3 CH： Η CH (CH3)CH2SCH3 CH, Η CH (CH3)CH2SCH3 CH： Η CH (CH3)CH2SCH3 CH, Η CH (CH3)CH2SCH3 CH： Η CH (CH3)CH2SCH3 CH, Η CH (CH3)CH2SCH3 CH, Η CH (CH3)CH2SCH3 CH: Η CH (CH3)CH2SCH3 CH, Η CH (CH3)CH2SCH3 CH, Η CH (CH3)CH2SCH3 CH, Η CH (CH3)CH2SCH3 CH. Η CH (CH3)CH2SCH3 CH, 273 CF3 Ph-4-CN cf3 Ph-3,4-Cl2 Ph_4-F ch3 Ph-4-Cl ch3 Ph-4-Br ch3 Ph-4-CF3 ch3 Ph-4-0CHF2 ch3 Ph-4_0CF3 ch3 cf3 Ph-4-F cf3 Ph-4-Cl cf3 Ph~4~Br cf3 Ph-4-0CF3 Ph-4-0CF3 ch3 ch3 Ph-4~F ch3 Ph-4-Cl ch3 Ph-4-Br ch3 Ph-4-I ch3 Ph-4-CF3 ch3 Ph-4-0CHF2 ch3 Ph-4-0CF3 ch3 Ph-4_0CF2Br ch3 Ph-4-0CF2CHF2 ch3 Ph-4-0CF2CHFCl ch3 Ph-4-0CF2CHFCF3 ch3 Ph-4-0CF2CHF0CF ch3 Ph-4-0CF2CHF0CF2CF2C ch3 Ph-4-0S02CH3 ch3 Ph-4-CN ch3 Ph- 3，[F2 ch3 Ph-3-F-4-Cl ch3 Ph-3, 4-Cl2 Et Ph_4_F Et Ph+Cl Et Ph-4-Br Et Ph-4-CF3 Et Ph+0CHF2 Et Ph+0CF3 314918 200407073 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH(CH3)CH2SCH3 ch3 n - Pr ch3 n-Pr ch3 n-Pr ch3 n，Pr ch3 n - Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 i-Pr ch3 n-Bu ch3 chf2 ch3 chf2 ch3 chf2 ch3 chf2 ch3 chf2 ch3 chf2 ch3 chf2 ch3 chf2 ch3 chf2 ch3 chf2 ch3 chf2 ch3 chf2 ch3 chf2 ch3 chf2 ch3 chf2 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3
Ph-4-F Ph-4-Cl Ph-4-Br Ph-4-CF3 Ph-4-0CF3 Ph-4-F Ph-4-Cl Ph_4-Br Ph-4-CF3 Ph-4-0CF3 Ph-4-Cl Ph~4_F Ph-4-Cl Ph-4-Br Ph-4-I Ph-4-CF3 Ph-4-0CHF2 Ph-4-0CF3 . Ph-4-0CF2Br Ph-4-0CF2CHF2 Ph-4-0CF2CHFCF Ph-4-0S02CH3 Ph-4-CN Ph-3,4-F2 Ph-3-F-4-C1 Ph-3,4-Cl2 Cl Br CH3 Et n~Pr i-Pr c-Pr n-Bu c-Bu c-Pen
274 314918 200407073
Η CH (CH3)CH2SCH3 ch3 cf3 c-Hex Η CH (CH3)CH2SCH3 ch3 cf3 ch2ch2cf3 Η CH (CH3)CH2SCH3 ch3 cf3 CH (CH3)CF； Η CH (CH3)CH2SCH3 ch3 cf3 M Η CH (CH3)CH2SCH3 ch3 cf3 T-2 Η CH (CH3)CH2SCH3 ch3 cf3 T-3 Η CH (CH3)CH2SCH3 ch3 cf3 T-4 Η CH (CH3)CH2SCH3 ch3 cf3 T-5 Η CH (CH3)CH2SCH3 ch3 cf3 och3 Η CH (CH3)CH2SCH3 ch3 cf3 OEt Η CH (CH3)CH2SCH3 ch3 cf3 OPr-n Η CH (CH3)CH2SCH3 ch3 cf3 OPr-i Η CH (CH3)CH2SCH3 ch3 cf3 OBu-n Η CH (CH3)CH2SCH3 ch3 cf3 OBu-i Η CH (CH3)CH2SCH3 ch3 cf3 OCH2Pr-c Η CH (CH3)CH2SCH3 ch3 cf3 OBu-s Η CH (CH3)CH2SCH3 ch3 cf3 OBu-t Β CB XB3) CB2SCB3 ch3 CFs DHex-n Η CH (CH3)CH2SCH3 ch3 cf3 OCH2CF3 Η CH (CH3)CH2SCH3 ch3 cf3 OCH (CF3) 2 Η CH (CH3)CH2SCH3 ch3 cf3 sch3 Η CH (CH3)CH2SCH3 ch3 cf3 SEt Η CH (CH3)CH2SCH3 ch3 cf3 SPr-n Η CH (CH3)CH2SCH3 ch3 cf3 SPr-i Η CH (CH3)CH2SCH3 ch3 cf3 SBu-n Η CH (CH3)CH2SCH3 ch3 cf3 sch2cf3 Η CH (CH3)CH2SCH3 ch3 cf3 SPh Η CH (CH3)CH2SCH3 ch3 cf3 N(CH3) 2 Η CH (CH3)CH2SCH3 ch3 cf3 N(CH3)Et Η CH (CH3)CH2SCH3 ch3 cf3 N(Et)2 Η CH (CH3)CH2SCH3 ch3 cf3 C(0)0Bu -1 Η CH (CH3)CH2SCH3 ch3 cf3 C(0) 0CH2CF Η CH (CH3)CH2SCH3 ch3 cf3 T-22 Η CH (CH3)CH2SCH3 ch3 cf3 T-23 Η CH (CH3)CH2SCH3 ch3 cf3 T-24 Η CH (CH3)CH2SCH3 ch3 cf3 Ph Η CH (CH3)CH2SCH3 ch3 cf3 Ph-2-F 275 314918 200407073 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3(R) H CH(CH3)CH2SCH3 ⑸ H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH 2SCH3 ch3 cf3 Ph-3-F ch3 cf3 Ph-4-F ch3 cf3 Ph+Cl ch3 cf3 Ph-4-C1 ch3 cf3 Ph+Cl ch3 cf3 Ph-4-Cl ch3 cf3 Ph-4-Br ch3 cf3 Ph-4-I ch3 cf3 Ph-4-CF3 ch3 cf3 Ph-4-0CHF2 ch3 cf3 Ph-4-0CF3 ch3 cf3 Ph_4_0CF2Br ch3 cf3 Ph-4-0CH2CF3 ch3 cf3 Ph-4-0CF2CHF2 ch3 cf3 Ph-4-0CF2CHFC1 ch3 cf3 Ph-4-0CF2CHFBr ch3 cf3 Ph-4-0CF2CF2Br ch3 cf3 Ph-4-0CF2CFCl2 ch3 cf3 Ph-4-0CF2CCl3 ch3 cf3 Ph-4-0CH2CF2CHF ch3 cf3 Ph_3-0CF2CHFCF3 ch3 cf3 Ph-4_0CF2CHFCF3 ch3 cf3 Ph-4-0CH (CF3) 2 ch3 CFa Ph-4-OCF2CFBrCF: ch3 cf3 Ph-3~0CF2CHF0CF； ch3 cf3 Ph-4~0CF2CHF0CF； ch3 cf3 Ph-4-0CF2CHF0CF2CF2CF ch3 cf3 Ph-4-0S02CH3 ch3 cf3 Ph-4-0S02CF 3 ch3 cf3 Ph-4-0 (L-45g) ch3 cf3 Ph-4-0 (L-451) ch3 cf3 Ph-4-SCH3 ch3 cf3 Ph_4-S02CH3 ch3 cf3 Ph-4-N02 ch3 cf3 Ph-4-CN ch3 cf3 Ph-2, 3-F2 ch3 cf3 Ph-2, 4-F 2 276 314918 200407073 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3, 4-F2 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-2,5-F2 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3,5-F2 Η CH (CH3)CH2SCH3 ch3 cf3 Ph_2-Cl_4-F Η CH (CH3)CH2SCH3 ch3 cf3 Ph-2-F-3-Cl Η CH (CH3)CH2SCH3 ch3 cf3 Ph - 3-H-4-F Η CH (CH3)CH2SCH3 ch3 cf3 Ph-2-F-4-Cl Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3-F-4-C1 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-2, 3-Cl2 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-2, 4-Cl2 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-2, 5-Cl2 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3, 4-C12 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3, 5~C12 Η CH (CH3)CH2SCH3 ch3 cf3 Ph - 3-Br-4&quot;~F Η CH (CH3)CH2SCH3 ch3 cf3 Ph_2HF_4-Br Η CH (CH3)CH2SCH3 ch3 cf3 Ph-2-F-5-Br Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3, 4-Br2 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3,5-Βγ2 . Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3-CH3-4-F Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3-F-4-CH3 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-2-F-5-CH3 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-2,4-(CH3)2 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3,4-(CH3) 2 Η CH (CH3)CH2SCH3 ch3 cf3 Ph - 2-F+CF3 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3-CF3_4_F Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3-CF3-4-Cl Η CH (CH3)CH2SCH3 ch3 cf3 Ph-2-F_4-CF3 Η CH (CH3)CH2SCH3 ch3 cf3 Ph - 3-F+CF3 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-2-F+CF3 Η CH (CH3)CH2SCH3 ch3 cf3 Pli-3+5 - CF3 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3,5-(CF3)2 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3-Br-4-0CH3 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3-F-4-0CHF2 Η CH (CH3)CH2SCH3 ch3 cf3 Ph_3-Cl-4_0CHT Η CH (CH3)CH2SCH3 ch3 cf3 Pb-3-Br-4-0CHF Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3-F-4-0CF3
277 314918 200407073 Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF； Η CH (CH3)CH2SCH3 ch3 CF； Η CH (CH3)CH2SCH3 ch3 CF Η CH (CH3)CH2SCH3 ch3 CF, Η CH (CH3)CH2SCH3 ch3 CF, Η CH (CH3)CH2SCH3 ch3 CF； Η CH (CH3)CH2SCH3 ch3 CF； Η CH (CH3)CH2SCH3 ch3 CF； Η CH (CH3)CH2SCH3 ch3 CF； 278
Ph-3-Cl-4-0CF3 Ph-3-Br~4-OCF3 Ph-3-F-4-0CF2Br Ph-3-CH-0CF2Br Ph-3-Br-4-0CF2Br Ph-3-F-4-0CF2CHF2 Ph - 3-U-4-0CF2CHF2 Ph-3-Br-4-0CF2CHF2 Ph-3-F-4_0CF2CHFCl Ph-3-C1-4-0CF2CHFCl Ph-3-Br-4-0CF2CHFCl m
Ph-3-F+0CF“HFCF3 響
Ph-3-C卜4-0CF2CHFCF3 Ph-3-Br-4-0CF2CHFCF3 Ph-3-F-4-0CF2CHF0CF3 Ph-3-C卜4-0CF2CHF0CF3 Ph-3-Br-4-0CF2CHF0CF3 Ph-3-F-4~0CF2CHF0CF2CF2CF3 Ph-3-Cl-4-0CF2CHF0CF2CF2CF3 Ph - 3-B卜4-OCF2CHFOCF2CF2CF3 Ph(-3-0CF2(HH Ph (-3-OCF2CF20-4-)
Ph-3-〇Ph-4-F Ph^3~N02~4-F Ph-3-N02-4-Cl Ph-2-F-5-N02 Ph-3_CN-4-F Ph-2, 3, 4-F3 Ph-2,3,5-F3 Ph - 2Λ5-F3 Ph-3,4,5-F3 Ph-2,3-F2-4 - CH3 Ph-2, 3-F2 -4_CF3 Ph_3, 4~F2~5~CF3 Ph-2-F-3-C1-5-CF 3 1-Naph 314918 200407073 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH(CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 ch3 cf3 2-Naph ch3 cf3 L-lb ch3 cf3 L_lc ch3 cf3 L - Id ch3 cf3 L - le ch3 cf3 L-li ch3 CFa L - 2b ch3 cf3 L-3b ch3 cf3 L-3c ch3 cf3 L-3d ch3 cf3 L-3e ch3 cf3 L-3f ch3 cf3 L-3j ch3 cf3 L-3k ch3 cf3 L-31 ch3 cf3 L - 3o ch3 cf3 L - 4b ch3 cf3 L-4c ch3 cf3 L_4e ch3 cf3 卜10b ch3 cf3 L - 10c ch3 cf3 L - 14b ch3 cf3 L - 14c ch3 cf3 L- 14d ch3 cf3 L - 14e ch3 cf3 L-14f ch3 cf3 L]4g ch3 cf3 L-14h ch3 cf3 L_16a ch3 cf3 L-16b ch3 cf3 L - 17a ch3 cf3 L-21b ch3 cf3 L~2 lc ch3 cf3 L - 21e ch3 cf3 L - 22b ch3 cf3 L - 22c
279 314918 200407073 Η CH (CH3)CH2SCH3 ch3 cf3 L - 23b Η ch(ch3)ch2sch3 ch3 cf3 L - 23c Η CH (CH3)CH2SCH3 ch3 cf3 L-23f Η CH (CH3)CH2SCH3 ch3 cf3 L-23g Η CH (CH3)CH2SCH3 ch3 cf3 L - 24b Η CH (CH3)CH2SCH3 ch3 cf3 卜24c Η CH (CH3)CH2SCH3 ch3 cf3 L-24d Η CH (CH3)CH2SCH3 ch3 cf3 L-24e Η CH (CH3)CH2SCH3 ch3 cf3 L~31a Η CH (CH3)CH2SCH3 ch3 cf3 L-31b Η CH (CH3)CH2SCH3 ch3 cf3 L_36b Η CH (CH3)CH2SCH3 ch3 cf3 L-36c Η CH (CH3)CH2SCH3 ch3 cf3 L-36d Η CH (CH3)CH2SCH3 ch3 cf3 L - 45c Η CH (CH3)CH2SCH3 ch3 cf3 L-45d Η CH (CH3)CH2SCH3 ch3 cf3 L-45e Η CH (CH3)CH2SCH3 ch3 cf3 L-45f Η CH (CH3)CH2SCH3 ch3 cf3 L - 45g Η CH (CH3)CH2SCH3 ch3 cf3 L - 45m Η CH (CH3)CH2SCH3 ch3 cf3 L-46c Η CH (CH3)CH2SCH3 ch3 cf3 L - 46d Η CH (CH3)CH2SCH3 ch3 cf3 L~46e Η CH (CH3)CH2SCH3 ch3 cf3 L-46g Η CH (CH3)CH2SCH3 ch3 cf3 L - 46j Η CH (CH3)CH2SCH3 ch3 cf3 L-46k Η CH (CH3)CH2SCH3 ch3 cf3 L - 46r Η CH (CH3)CH2SCH3 ch3 cf3 L-47a Η CH (CH3)CH2SCH3 ch3 cf3 L-48b Η CH (CH3)CH2SCH3 ch3 cf3 L - 50b Η CH (CH3)CH2SCH3 ch3 cf3 L-50c Η CH (CH3)CH2SCH3 ch3 cf3 L-51b Η CH (CH3)CH2SCH3 ch3 cf2ci Ph~4_F Η CH (CH3)CH2SCH3 ch3 cf2ci Ph+Cl Η CH (CH3)CH2SCH3 ch3 cf2ci Ph+Br Η CH (CH3)CH2SCH3 ch3 cf2ci Ph-4-CF3 Η CH (CH3)CH2SCH3 ch3 cf2ci Ph-4_0CHF Η CH (CH3)CH2SCH3 ch3 cf2ci Ph-4-0CF3
280 314918 200407073 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 ch3 cf2ci Ph-4-CN ch3 cf2ci Ph-3,4-Cl2 ch3 CF2Br Ph-4-Br ch3 cf2chf2 Ph-4-0CF3 ch3 cf2cf3 Ph-4-F ch3 cf2cf3 Ph-4-Cl ch3 cf2cf3 Ph_4-Br ch3 cf2cf3 Ph-4-I ch3 cf2cf3 Ph+CF3 ch3 cf2cf3 Ph-4-0CHF2 ch3 cf2cf3 Ph-4-0CF3 ch3 cf2cf3 Ph-4-0CF2Br ch3 cf2cf3 Ph-4-0CF2CHF2 ch3 cf2cf3 Ph-4-0CF2CHFCF ch3 cf2cf3 Ph-4-0S02CH3 ch3 cf2cf3 Ph-4-CN ch3 cf2cf3 Ph-3, 4_F2 ch3 cf2cf3 Ph-3-F-4-Cl . ch3 cf2cf3 Ph-3,4-Cl2 ch3 cf2cf2ci Ph+Cl ch3 CFC1CF3 Ph-4-Br ch3 CFC1CF2C1 Ph-4-0CF3 ch3 cf2cf2cf3 Ph-4-Cl ch3 CF (CF3) 2 Ph-4-Br ch3 cf2cf2cf2cf3 Ph-4-0CF3 ch3 Ph ch3 ch3 Ph-2-F ch3 ch3 Ph-3-F ch3 ch3 Ph_4-F ch3 ch3 Ph-4-F Ph-4-Cl ch3 Ph-4-Cl ch3 ch3 Ph+Cl PM-Cl ch3 Ph_4-Br ch3 ch3 Ph-4-Br Ph-4-Cl ch3 Ph-4-CF3 ch3 ch3 Ph-4_CF3 Ph+Cl ch3 Ph-4-0CHF2 ch3
281 314918 200407073 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 ch3 Ph-4-0CF3 Cl ch3 Ph-4_0CF3 ch3 ch3 Ph-4-0CF3 cf3 ch3 Ph-4-0CF3 och3 ch3 Ph-4-0CF3 och2cf3 ch3 Ph-4-0CF3 sch3 ch3 Ph-4-0CF3 n(ch3)2 ch3 Ph-4-0CF3 Ph-4-Cl ch3 Ph-4-0CF2Br Cl ch3 Ph+0CF2Br ch3 ch3 Ph_4-0CF2Br OCH 3 ch3 Ph-4-0CH2CF3 ch3 ch3 Ph-4-0CF2CHF2 ch3 ch3 Ph-4~0CF2CHFC1 ch3 ch3 Ph-4-0CF2CHFBr ch3 ch3 Ph-4-0CF2CF2Br ch3 ch3 Ph-4-0CF2CFCl2 ch3 ch3 Ph-4_0CF2CHFCF3 Cl ch3 Ph-4-0CF2CHFCF3 ch3 ch3 Ph-4-0CF2CHFCF3 OCH 3 ch3 Ph-4-0CH (CF3) 2 ch3 ch3 Ph-4-0CF2CFBrCF； 3 CH3 ch3 Ph-4-0CF2CHF0CF: 3 CH3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 Cl ch3 Ph-4-0CF2CHF0CF2CF2CF3 CH3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 OCH ch3 Ph-4-0S02CH3 ch3 ch3 Ph-4-0 (L-45g) ch3 ch3 Ph - 4-0(L-451) ch3 ch3 Ph-4-SCH3 ch3 ch3 Ph-4~S02CH3 ch3 ch3 Ph+CN ch3 ch3 Ph-3’4-F2 ch3 ch3 Ph-3_F_4-Cl ch3 ch3 Ph - 3,4—Cl2 ch3 ch3 Ph-2-Cl-4-CF3 ch3 ch3 L-lc ch3
282 314918 200407073
H CH (CH3)CH2SCH3 ch3 L-ld ch3 H CH (CH3)CH2SCH3 ch3 L - le ch3 H CH (CH3)CH2SCH3 ch3 L- li ch3 H CH (CH3)CH2SCH3 ch3 L - 2b ch3 H CH (CH3)CH2SCH3 ch3 L-3c ch3 H CH (CH3)CH2SCH3 ch3 L-3d ch3 H CH (CH3)CH2SCH3 ch3 L - 3e ch3 H CH (CH3)CH2SCH3 ch3 L-3f ch3 H CH (CH3)CH2SCH3 ch3 L - 3k ch3 H CH (CH3)CH2SCH3 ch3 L-31 ch3 H CH (CH3)CH2SCH3 ch3 L-3o ch3 H CH (CH3)CH2SCH3 ch3 L - 4b ch3 H CH (CH3)CH2SCH3 ch3 L-4c ch3 H CH (CH3)CH2SCH3 ch3 L-45d ch3 H CH (CH3)CH2SCH3 ch3 L-45e ch3 H CH (CH3)CH2SCH3 ch3 L-45f ch3 H CH (CH3)CH2SCH3 ch3 L-45g ch3 H CH (CH3)CH2SCH3 ch3 L-45m ch3 H CH (CH3)CH2SCH3 ch3 L - 46d ch3 H CH (CH3)CH2SCH3 ch3 L-46e ch3 H CH (CH3)CH2SCH3 ch3 L - 46i ch3 H CH (CH3)CH2SCH3 ch3 L-46g ch3 H CH (CH3)CH2SCH3 ch3 L - 46j ch3 H CH (CH3)CH2SCH3 ch3 L - 46k ch3 H CH (CH3)CH2SCH3 ch3 L - 46r ch3 H CH (CH3)CH2SCH3 ch3 L-47a ch3 H CH (CH3)CH2SCH3 ch3 L-47e ch3 CH3CH (CH3)CH2SCH3 ch3 cf3 Ph-4-Cl EtCH (CH3)CH2SCH3 ch3 Ph_4-0CF3 ch3 H CH (CH3)CH2SCH3 Et cf3 Ph-4-Cl H CH(CH3)CH2S(0)CH3 ch3 ch3 Ph-4-F H CH (CH3)CH2S(0) CH3 ch3 ch3 Ph-4-U H CH (CH3)CH2S(0) CH3 ch3 ch3 Ph~4~Br H CH (CH3)CH2S(0) CH3 ch3 ch3 Ph+CF3 H CH (CH3)CH2S(0) CH3 ch3 ch3 Pli - 4-OCHF H CH (CH3)CH2S(0) CH3 ch3 ch3 Ph+0CF3 H CH (CH3)CH2S(0) CH3 ch3 cf3 Ph-4~F
283 314918 200407073 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 ch3 cf3 Ph-4-Cl ch3 cf3 Ph-4-Br ch3 cf3 Ph-4，I ch3 cf3 Ph-4-CF3 ch3 cf3 Ph-4-0CHF2 ch3 cf3 Ph-4-0CF3 ch3 cf3 Ph-4-0CF2Br ch3 cf3 Ph-4-0CF2CHF2 ch3 cf3 Ph-4-0CF2CHFCl ch3 cf3 Ph-4-0CF2CHFBr ch3 cf3 Ph-4-0CF2CF2Br ch3 cf3 Ph-4-0CF2CFCl2 ch3 cf3 Ph-4-0CF2CCl3 ch3 cf3 Ph+OCF2CHFCF3 ch3 cf3 Ph-4-0CH(CF3) 2 ch3 cf3 Ph-4-OCF2CFBrCF3 ch3 cf3 Ph_4_0CF2CHF0CF3 ch3 cf3 Ph-4-0CF2CHF.0CF2CF2CF3 ch3 cf3 Ph-4-0S02CH3 ch3 cf3 Ph-4-0 (L - 45g) ch3 cf3 Ph - 4-0(L-451) ch3 cf3 Ph-4-S02CH3 ch3 cf3 Ph-4-CN ch3 cf3 Ph-3,4-F2 ch3 cf3 Ph-3-F-4_C1 ch3 cf3 Ph-3，[C12 ch3 cf3 L - 45d ch3 cf3 L-45e ch3 cf3 L - 45i ch3 cf3 L - 45g ch3 cf3 L_45m ch3 cf3 L-46d ch3 cf3 L-46e ch3 cf3 L-46f ch3 cf3 L - 46g ch3 cf3 L-46j ch3 cf3 L-46k
284 314918 200407073 Η ch(ch3)ch2s(o)ch3 ch3 cf3 L-46r Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-F ch3 Η ch(ch3)ch2s(o)ch3 ch3 Ph-4-F Ph-4-Cl Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-Cl ch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-Cl Ph-4-Cl Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-Br ch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-Br Ph-4-Π Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-CF3 ch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-CF3 Ph-4-Cl Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0CHF2 ch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0CF3 Cl Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0CF3 cf3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0CF3 och3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0CF3 och2cf3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0CF3 sch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0CF3 n(ch3)2 Η CH (CH3)CH2S(0)CH3 ch3 Ph-4-0CF3 Ph-4rCl Η CH (CH3)CH2S(0) ch3 ch3 Ph-4-0CF2Br Cl Η CH (CH3)CH2S(0) CH3 ch3 Ph~4-0CF2Br ch3 Η CH (CH3)CH2S(0) CH3 ch3 Pb-4_0CF2Br och3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0CH2CF3 ch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4_0CF2CHF2 ch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0CF2CHFCl ch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4_0CF2CHFBr ch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4_0CF2CF2Br ch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0CF2CFCl2 ch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0CF2CHFCF3 Cl Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0CF2CHFCF3 ch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0CF2CHFCF3 och3 Η ch(ch3)ch2s_3 ch3 Ph-4-0CH (CF3)2 ch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0CF2CFBrCF3 ch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph~4-0CF2CHF0CF3 ch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 Cl Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 ch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-H)CF2CHFOCF2CF2CF3 〇ch3 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0 (L-45g) ch3
285 314918 200407073 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH(CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH(CH3)CR2S02CH3 ch3 Ph-4-0(L - 451) ch3 Ph-4-S02CH3 ch3 Ph+CN ch3 Ph-3, 4-F 2 ch3 Ph-3-F-4-C! ch3 Ph-3, 4-Cl2 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 Et ch3 Et ch3 Et ch3 Et ch3 Et ch3 Et ch3 Et ch3 Et ch3 n-Pr ch3 i-Pr ch3 n-Bu ch3 chf2 ch3 chf2 ch3 ch3 ch3 ch3 ch3 ch3
Ph-4-F
Ph-4-Cl
Ph-4-Br
Ph+I
Ph-4-CF3
Ph-4-0CHF2 '
Ph-4-0CF3
Ph-4-0CF2Br
Ph-4-0CF2CHF2
Ph-4-0CF2CHFCl
Ph-4-0CF2CHFCF3
Ph~4~0CF2CHF0CF3
Ph-4-0CF2CHF0CF2CF2CF3
Ph-4-0S02CH3
Ph-4-CN
Ph~3T 4-F 2
Ph-3-F-4-Cl
Ph~3, 4~C12
Ph-4-F
Ph-4-Cl
Ph-4-Br
Ph-4-CF3
Ph-4-0CHF2
Ph-4-0CF3
Ph-4-CN
Ph-3,4-Cl2
Ph-4-Cl
Ph+Br
Ph-4_0CF3
Ph-4-F
Ph-4-Cl 286 314918 200407073 Η ch(ch3)ch2so2ch3 ch3 chf2 Ph-4-Br Η CH (CH3)CH2S02CH3 ch3 chf2 Ph-4~CF 3 Η CH (CH3)CH2S02CH3 ch3 chf2 Ph-4-0CHF2 Η CH (CH3)CH2S02CH3 ch3 chf2 Ph-4-0CF3 Η CH (CH3)CH2S02CH3 ch3 chf2 Ph-4-CN Η CH (CH3)CH2S02CH3 ch3 chf2 Ph-3, 4-Cl2 Η CH (CH3)CH2S02CH3 ch3 cf3 Cl Η CH (CH3)CH2S02CH3 ch3 cf3 Br Η CH (CH3)CH2S02CH3 ch3 cf3 ch3 Η CH (CH3)CH2S02CH3 ch3 cf3 Et Η CH (CH3)CH2S02CH3 ch3 cf3 i-Pr Η CH (CH3)CH2S02CH3 ch3 cf3 c-Pr Η CH (CH3)CH2S02CH3 ch3 cf3 0CH3 Η CH (CH3)CH2S02CH3 ch3 cf3 OEt Η CH (CH3)CH2S02CH3 ch3 cf3 OPr-n Η CH (CH3)CH2S02CH3 ch3 cf3 OPr-i Η CH (CH3)CH2S02CH3 ch3 cf3 OBu - n Η CH (CH3)CH2S02CH3 ch3 cf3 sch3 . Η CH (CH3)CH2S02CH3 ch3 cf3 SEt Η CH (CH3)CH2S02CH3 ch3 cf3 SPr-n Η CH (CH3)CH2S02CH3 ch3 cf3 SPr - i Η CH (CH3)CH2S02CH3 c,h3 cf3 N(CH3)2 Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-F Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-Br Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-I Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-OCHF2 Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-0CF2Br Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-0CF2CHF2 Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4~0CF2CHFC1 Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-0CF2CHFBr Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-0CF2CF2Br Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-0CF2CFC12 Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-0CF2CCl3 Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-0CF2CHFCF: 287
314918 200407073 Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-0CH(CF3)2 Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-0CF2CFBrCF3 Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4_0CF2CHF0CF3 Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-0CF2CHF0CF2 Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-0S02CH3 Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-0 (L-45g) Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-0 (L-451) Η CH (CH3)CH2S02CH3 ch3 cf3 Ph+SCH3 Η CH (CH3)CH2S02CH3 ch3 CFa Ph-4-S02CH3 Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-4-CN Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-3, 4-F2 Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-3-F-4-C1 ' Η CH (CH3)CH2S02CH3 ch3 cf3 Ph-3,4-Cl2 Η CH (CH3)CH2S02CH3 ch3 cf3 L-lb Η CH (CH3)CH2S02CH3 ch3 cf3 L- lc Η CH (CH3)CH2S02CH3 ch3 cf3 L-le Η CH (CH3)CH2S02CH3 ch3 cf3 L-li Η CH (CH3)CH2S02CH3 ch3 cf3 L - 2b . Η CH (CH3)CH2S02CH3 ch3 cf3 L - 3b Η CH (CH3)CH2S02CH3 ch3 cf3 L - 3c Η CH (CH3)CH2S02CH3 ch3 cf3 L - 3d Η CH (CH3)CH2S02CH3 ch3 cf3 L-3f Η CH (CH3)CH2S02CH3 ch3 cf3 L-3j Η CH (CH3)CH2S02CH3 ch3 cf3 L - 3k Η CH (CH3)CH2S02CH3 ch3 cf3 L-31 Η CH (CH3)CH2S02CH3 ch3 cf3 L-4b Η CH (CH3)CH2S02CH3 ch3 cf3 L-4c Η CH (CH3)CH2S02CH3 ch3 cf3 L-4e Η CH (CH3)CH2S02CH3 ch3 cf3 L- 10b Η CH (CH3)CH2S02CH3 ch3 cf3 L-lOc Η CH (CH3)CH2S02CH3 ch3 cf3 L-14b Η CH (CH3)CH2S02CH3 ch3 cf3 L-14c Η CH (CH3)CH2S02CH3 ch3 cf3 L-14d Η CH (CH3)CH2S02CH3 ch3 cf3 L~14e Η CH (CH3)CH2S02CH3 ch3 cf3 L-14f Η CH (CH3)CH2S02CH3 ch3 cf3 L-14h Η CH (CH3)CH2S02CH3 ch3 cf3 L - 16a 2^3 288 314918 200407073 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH(CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 ch3 cf3 L- 16b ch3 cf3 L-17a ch3 cf3 L - 21b ch3 cf3 L-2 lc ch3 cf3 L-21e ch3 cf3 L-22b ch3 cf3 L-22c ch3 cf3 L-23b ch3 cf3 L - 23c ch3 cf3 L - 23f ch3 cf3 L - 23g ch3 cf3 L - 24b ch3 cf3 L-24c ch3 cf3 L-24e ch3 cf3 L-31a ch3 cf3 L-3 lb ch3 cf3 L-36b ch3 cf3 L - 36c ch3 cf3 L - 36d ch3 cf3 L-45c ch3 cf3 L-45d ch3 cf3 L-45e ch3 cf3 L-45i ch3 cf3 L-45g ch3 cf3 L-45m ch3 cf3 L-46c ch3 cf3 L - 46d ch3 cf3 L-46e ch3 cf3 L-46i ch3 cf3 L-46g ch3 cf3 L - 46j ch3 cf3 L-46k ch3 cf3 L，46r ch3 cf3 L-47a ch3 cf3 L - 48b ch3 cf3 L-50b ch3 cf3 L-50c
289 314918 200407073 Η ch(ch3)ch2so2ch3 ch3 cf3 L-50d Η CH (CH3)CH2S02CH3 ch3 cf3 L-51b Η CH (CH3)CH2S02CH3 ch3 cf2ci Ph-4~F Η CH (CH3)CH2S02CH3 ch3 cf2ci Ph-4~C1 Η CH (CH3)CH2S02CH3 ch3 cf2ci Ph_4-Br Η CH (CH3)CH2S02CH3 ch3 cf2ci Ph-4-CF3 Η CH (CH3)CH2S02CH3 ch3 cf2ci Ph-4-OCHF Η CH (CH3)CH2S02CH3 ch3 cf2ci Ph-4-0CF3 Η CH (CH3)CH2S02CH3 ch3 cf2ci Ph-4-CN Η CH (CH3)CH2S02CH3 ch3 cf2ci Ph-3,4-Cl Η CH (CH3)CH2S02CH3 ch3 CF2Br Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 cf2cf3 Ph-4-F Η CH (CH3)CH2S02CH3 ch3 cf2cf3 Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 cf2cf3 Ph-4-Br Η CH (CH3)CH2S02CH3 ch3 cf2cf3 Ph-4-CF3 Η CH (CH3)CH2S02CH3 ch3 cf2cf3 Ph-4-0CHF Η CH (CH3)CH2S02CH3 ch3 cf2cf3 Ph-4-0CF3 Η CH (CH3)CH2S02CH3 ch3 cf2cf3 Ph-4-CN Η CH (CH3)CH2S02CH3 ch3 cf2cf3 Ph-3, 4-C1； Η CH (CH3)CH2S02CH3 ch3 cf2cf2cf3 Ph-4-Br Η CH (CH3)CH2S02CH3 ch3 Ph_4-F ch3 Η CH (CH3)CH2S02CH3 ch3 Ph_4-F Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 Ph-4-C1 ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-Cl Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 Ph-4-Br ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-Br Ph+Cl Η CH(CH3)CH2S02CH3 ch3 Ph-4-CF3 ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-CF3 Ph~*4-Cl Η ch(ch3)ch2so2ch3 ch3 Ph-4-0CHF2 ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0C.F3 Cl Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF3 cf3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF3 och3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF3 och2cf3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF3 sch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF3 N(CH3)2 Η CH(CH3)CH2S02CH3 ch3 Ph-4-0CF3 Ph-4-Cl 290
314918 200407073 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF2Br Cl Η CH (CH3)CH2S02CH3 ch3 Ph-4~0CF2Br ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF2Br 〇ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CH2CF3 ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF2CHF2 ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF2CHFCl ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF2CHFBr ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF2CF2Br ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF2CFCl2 ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF2CHFCF3 Cl Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF2CHFCF3 ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF2CHFCF3 〇ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CH (CF3) 2 ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF2CFBrCF3 ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF2CHF0CF3 ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 Cl Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 OCH^ Η CH (CH3)CH2S02CH3 ch3 Ph-4_0S02CH3 ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-0 (L - 45g) ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4 - 0(L - 45]) ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-S02CH3 ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-4-CN ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-3, 4-F2 ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-3-F-4-Cl ch3 Η CH (CH3)CH2S02CH3 ch3 Ph-3, 4-Cl2 ch3 Η CH (CH3)CH2S02CH3 ch3 L-lc ch3 Η CH (CH3)CH2S02CH3 ch3 L-ld ch3 Η CH (CH3)CH2S02CH3 ch3 L - le ch3 Η CH (CH3)CH2S02CH3 ch3 L- li ch3 Η CH (CH3)CH2S02CH3 ch3 L - 2b ch3 Η CH (CH3)CH2S02CH3 ch3 L - 3c ch3 Η CH (CH3)CH2S02CH3 ch3 L-3d ch3 Η CH (CH3)CH2S02CH3 ch3 L - 3e ch3 Η CH (CH3)CH2S02CH3 ch3 L-3f ch3 Η CH (CH3)CH2S02CH3 ch3 L-3k ch3 Η CH (CH3)CH2S02CH3 ch3 L-31 ch3
291 314918 200407073 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2SEt(R) H CH (CH3)CH2SEt(S) H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2SEt ch3 L - 3o ch3 L - 4b ch3 L - 4c ch3 L - 45d ch3 L-45e ch3 L-45f ch3 L - 45g ch3 L - 46d ch3 L-46e ch3 L-46f ch3 L-46g ch3 L - 46j ch3 L-46k ch3 L - 46r ch3 L - 47a ch3 L-47e ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 CH3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ' ch3 ch3 ch3 ch3 Ph+F Ph+Cl . Ph - 4HBr Ph+Br Ph-4-Br Ph-4-I Ph+CF3 Ph-4-0CHF, Ph~4-〇CF 3 Ph-4-0CF2Br Ph-4-0CF2CHF2 Ph-4-0CF2CHFCF Ph+CN Ph-3, 4-F2 Ph-3-F-4-C1 Ph-3, 4-Cl2 L-46d L - 46e L-46g L-46j L - 46k
292 314918 200407073 Η CH (CH3)CH2SEt ch3 cf3 L_46r Η CH(CH3)CH2SEt ch3 Ph-4-F ch3 Η CH (CH3)CH2SEt ch3 Ph-4-Cl ch3 Η CH (CH3)CH2SEt ch3 Ph~4_Br ch3 Η CH (CH3)CH2SEt ch3 Ph-4-I ch3 Η CH (CH3)CH2SEt ch3 Ph+CF3 ch3 Η CH (CH3)CH2SEt ch3 Ph-4-0CHF2 ch3 Η CH (CH3)CH2SEt ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2SEt ch3 Ph-4-0CF2Br ch3 Η CH (CH3)CH2SEt ch3 Ph-4-0CF2CHF2 ch3 Η CH (CH3)CH2SEt ch3 Ph-4-0CF2CHFCF3 CH3 Η CH (CH3)CH2SEt ch3 Ph - 3,4-Cl2 ch3 Η CH (CH3)CH2S(0)Et ch3 cf3 Ph-4-F Η CH (CH3)CH2S(0)Et ch3 cf3 Ph+Cl Η CH (CH3)CH2S(0)Et ch3 cf3 Ph-4-Br Η CH 〇3)CH2S(0)Et ch3 cf3 Ph-4-I Η CH (CH3)CH2S(0)Et ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2S(0)Et ch3 cf3 Ph-4-0CHF〇 Η CH (CH3)CH2S(0)Et ch3 cf3 Ph-4_0CF3 Η CH (CH3)CH2S(0)Et ch3 cf3 Ph+0CF2Br Η CH (CH3)CH2S(0)Et ch3 cf3 Ph-4_0CF2CHF2 Η CH (CH3)CH2S(0)Et ch3 cf3 Ph-4-0CF2CHFCF Η CH (CH3)CH2S(0)Et ch3 cf3 Ph-4-CN Η CH (CH3)CH2S(0)Et ch3 cf3 Ph-3, 4-F2 Η CH (CH3)CH2S(0)Et ch3 cf3 Ph-3-F-4-C1 Η CH (CH3)CH2S(0)Et ch3 cf3 Ph-3, 4-Cl2 Η CH (CH3)CH2S(0)Et ch3 Ph_4~F ch3 Η CH (CH3)CH2S(0)Et ch3 Ph-4-Cl ch3 Η CH (CH3)CH2S(0)Et ch3 Ph-4-Br ch3 Η CH (CH3)CH2S(0)Et ch3 Ph-4-I ch3 Η CH (CH3)CH2S(0)Et ch3 Ph~4~CF 3 ch3 Η CH (CH3)CH2S(0)Et ch3 Ph-4-0CHF2 ch3 Η CH (CH3)CH2S(0)Et ch3 Ph-4_0CF3 ch3 Η CH (CH3)CH2S(0)Et ch3 Ph-4-0CF2Br ch3 Η CH (CH3)CH2S(0)Et ch3 Ph-4-0CF2CHF2 ch3 Η CH (CH3)CH2S(0)Et ch3 Ph-4-0CF2CHFCF3 ch3 Η CH (CH3)CH2S(0)Et ch3 Ph-3, 4-CI2 ch3 293
314918 200407073 Η CH(CH3)CH2S02Et ch3 cf3 Ph-4_F Η CH (CH3)CH2S02Et ch3 cf3 Ph-4-Cl Η CH (CH3)CH2S02Et ch3 cf3 Ph-4-Br Η CH (CH3)CH2S02Et ch3 cf3 Ph+I Η CH (CH3)CH2S02Et ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2S02Et ch3 cf3 Ph-4-0CHF2 Η CH (CH3)CH2S02Et ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2S02Et ch3 cf3 ph一4_〇cF2Br Η CH (CH3)CH2S02Et ch3 cf3 Ph-4-0CF2CHF2 Η CH (CH3)CH2S02Et ch3 cf3 Ph-4-0CF2CHFCF Η CH (CH3)CH2S02Et ch3 cf3 Ph-4-CN Η CH (CH3)CH2S02Et ch3 cf3 Ph-3,4-F2 Η CH (CH3)CH2S02Et ch3 cf3 Ph-3-F-4-Cl Η CH (CH3)CH2S02Et ch3 cf3 Ph_3,4_Cl2 Η CH (CH3)CH2S02Et ch3 cf3 L-46d Η CH (CH3)CH2S02Et ch3 cf3 L - 46e Η CH (CH3)CH2S02Et ch3 cf3 L-46g Η CH (CH3)CH2S02Et ch3 cf3 L-46j , Η CH (CH3)CH2S02Et ch3 cf3 L - 46k Η CH (CH3)CH2S02Et ch3 cf3 L - 46r Η CH (CH3)CH2S02Et ch3 Ph-4-F ch3 Η CH (CH3)CH2S02Et ch3 Ph-4-Cl ch3 Η CH (CH3)CH2S02Et ch3 Ph-4-Br ch3 Η CH (CH3)CH2S02Et ch3 Ph-4-CF3 ch3 Η CH (CH3)CH2S02Et ch3 Ph-4-0CHF2 ch3 Η CH (CH3)CH2S02Et ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2S02Et ch3 Ph-4-0CF2Br ch3 Η CH (CH3)CH2S02Et ch3 Ph-4-0CF2CHF2 ch3 Η CH (CH3)CH2S02Et ch3 Ph-4-0CF2CHFCF3 CH3 Η CH (CH3)CH2S02Et ch3 Ph - 3,4-Cl2 ch3 Η CH (CH3)CH2SPr-n ch3 cf3 Ph-4-F Η CH (CH3)CH2SPr-n ch3 cf3 Ph-4-Cl Η CH(CH3)CH2SPr - n ch3 cf3 Ph-4-Br Η CH(CH3)CH2SPr-n ch3 cf3 Ph-4-CF3 Η CH(CH3)CH2SPr - n ch3 cf3 Ph-4-0CHF2 Η CH(C.H3)CH2SPr - n ch3 cf3 Ph-4-0CF3 Η CH(CH3)CH2SPr-n ch3 Ph-4-F ch3
294 314918 200407073 Η CH(CH3)CH2SPr - η ch3 Ph-4-Cl ch3 Η CH (CH3)CH2SPr-n ch3 Ph-4-Br ch3 Η CH (CH3)CH2SPr-n ch3 Ph-4-CF3 ch3 Η CH (CH3)CH2SPr-n ch3 Ph-4_0CHF2 ch3 Η CH (CH3)CH2SPr-n ch3 Ph-4_0CF3 ch3 Η CH (CH3)CH2SPr-i ch3 cf3 Ph-4-Cl Η CH (CH3)CH2SPr-i ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2S02Pr-i ch3 cf3 Ph-4-Cl Η CH(CH3)CH2S02Pr - i ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2SBu-n ch3 cf3 Ph-4-Cl Η CH(CH3)CH2SBu - n ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2SBu-i ch3 cf3 Ph_4-F Η CH (CH3)CH2SBu-i ch3 cf3 Ph-4-Cl Η CH (CH3)CH2SBu-i ch3 cf3 Ph-4-Br Η CH (CH3)CH2SBu-i ch3 cf3 Ph_4-CF3 Η CH (CH3)CH2SBu-i ch3 cf3 Ph-4-0CHF Η CH(CH3)CH2SBiH ch3 cf3 Ph-4-0CF3 Η CH(CH3)CH2SBu - i ch3 Ph-4-F ch3 Η CH (CH3)CH2SBu-i ch3 Ph-4-Cl ch3 Η CH (CH3)CH2SBu-i ch3 Ph-4-Br ch3 Η CH (CH3)CH2SBu-i ch3 Ph-4-CF3 ch3 Η CH (CH3)CH2SBu-i ch3 Ph-4-0CHF2 ch3 Η CH(CH3)CH2SBiH ch3 Ph-4_0CF3 ch3 Η CH (CH3)CH2SBu-t ch3 cf3 Ph_4_F Η CH (CH3)CH2SBu-t ch3 cf3 Ph+Cl Η CH (CH3)CH2SBu-t ch3 cf3 Ph-4-Br Η CH (CH3)CH2SBu-t ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2SBu-t ch3 cf3 Ph-4-0CHF Η CH (CH3)CH2SBu-t ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2SBu-t ch3 Ph-4_F ch3 Η CH(CH3)CH2SBu -1 ch3 Ph-4-Cl ch3 Η CH (CH3)CH2SBu-t ch3 Ph-4-Br ch3 Η CH (CH3)CH2SBu-t ch3 Ph-4-CF3 ch3 Η CH (CH3)CH2SBu-t ch3 Ph-4-0CHF2 ch3 Η CH(CH3)CH2SBu -1 ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2S02Bu-t ch3 cf3 Ph-4-Cl Η CH(CH3)CH2S02Bu -1 ch3 Ph-4-0CF3 ch3
295 314918 200407073 H CH (CH3)CH2SHex-n H CH(CH3)CH2SHex - c H CH (CH3)CH2SCH2CF3 H CH (CH3)CH2S(0) CH2CF3 H CH (CH3)CH2S02CH2CF3
H CH (CH3)CH2SCH2CH2OH H CH (CH3)CH2SCH2CH2OCH3 H CH (CH3)CH2S(0) CH2CH20CH3 H CH (CH3)CH2S02CH2CH20CH3 H CH (CH3)CH2SCH2CH20Et H CH (CH3)CH2S(0) CH2CH20Et H CH (CH3)CH2S02CH2CH20Et H CH (CH3)CH2SCH2CH2OC (0) CF3 H CH (CH3)CH2SCH2CH2SCH3 H CH(CH3)CH2SCH2Si (CH3) 3 H CH (CH3)CH2SCH2Si(CH3)3 H CH(CH3)CH2SCH2Si (CH3) 3 H CH(CH3)CH2SCH2Si (CH3) 3 H CH (CH3)CH2SCH2Si(CH3)3 H CH(CH3)CH2SCH2Si (CH3) 3 H CH (CH3)CH2SCH2Si(CH3)3 H CH(CH3)CH2SCH2Si (CH3) 3 H CH (CH3)CH2SCH2Si(CH3) 3 H CH (CH3)CH2SCH2Si(CH3)3 H CH(CH3)CH2SCH2Si (CH3) 3 H CH (CH3)CH2SCH2Si (CH3) 3 H CH (CH3)CH2SCH2CH=CH2
H CH (CH3)CH2SCH2C=CH H CH (CH3)CH2SC (0) CH3 H CH (CH3)CH2SCH2C(0) CH3 H CH (CH3)CH2SCH2CH2C(0) 0CH3 H CH (CH3)CH2S(0) CH2CH2C(0) 0CH3 H CH (CH3)CH2S02CH2CH2C(0) 0CH3 H CH (CH3)CH2SC (O)NHEt H CH (CH3)CH2SC (0)N(CH3)2 H CH (CH3)CH2SC (O)N(Et) 2 H CH (CH 3)CH2SC (S)NHCH3
ch3 cf3 Ph_4-Cl ch3 Ph-4-OCF3 ch3 ch3 cf3 Ph+Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 PlHhCl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph+Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph+Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-F ch3 cf3 Ph-4-Cl ch3 cf3 Ph-4~Br ch3 cf3 Ph-4rCF3 ch3 cf3 P卜4-OCHF ch3 cf3 Ph-4-0CF3 ch3 Pii_4 - F ch3 ch3 Ph+Cl ch3 ch3 Ph+Br ch3 ch3 Ph-4-CF3 ch3 ch3 Ph-4-0CHF2 ch3 ch3 Ph+OCF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph_4_0CF 3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph+Cl ch3 Ph-4-OCF3 ch3 ch3 cf3 Ph+Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph+Cl ch3 Ph-4-0CF3 ch3 ch3 C-F3 Ph-4-Cl 296 314918 200407073 H CH (CH3)CH2SC (S) NHEt H CH (CH3)CH2SC (S)N(CH3) 2 H CH (CH3)CH2SCH2C(0)N(Et)2 H CH (CH3)CH2S(0) CH2C(0)N(Et)； H CH(CH3)CH2S02CH2C(0)N(Et) 2 H CH(CH3)CH2SCH2(Ph-2,4-Cl2) H CH (CH3)CH2SPh H CH (CH3)CH2SPh H CH (CH3)CH2SPh H CH (CH3)CH2SPh H CH (CH3)CH2SPh H CH (CH3)CH2SPh H CH (CH3)CH2SPh H CH (CH3)CH2SPh H CH (CH3)CH2SPh H CH (CH3)CH2SPh H CH (CH3)CH2SPh H CH (CH3)CH2SPh H CH(CH3)CH2S(L_21a) H CH(CH3)CH2S02(L_21a) H CH(CH3)CH2S(L - 45a) H CH(CH3)CH2S(L - 45a) H CH (CH3)CH2S(L-45a) H CH (CH3)CH2S(L-45a) H CH (CH3)CH2S(L-45a) H CH(CH3)CH2S(L - 45a) H CH(CH3)CH2S(L - 45a) H CH(CH3)CH2S(L - 45a) H CH(CH3)CH2S(L - 45a) H CH(CH3)CH2S(L，45a) H CH(CH3)CH2S(L - 45a) H CH (CH3)CH2S(L-45a) H CH(CH3)CH2S(0) (L-45a) H CH(CH3)CH2S(0) (L-45a) H CH(CH3)CH2S(0) (L-45a) H CH(CH3)CH2S(0) (L-45a) H CH(CH3)CH2S(0) (L-45a)
ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph+0CF3 ch3 ch3 cf3 Ph-4-C1 ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 cf3 Ph+F ch3 cf3 Ph-4-Cl ch3 cf3 Ph+Br ch3 cf3 Ph+CF3 ch3 cf3 Ph-4-OCHF ch3 cf3 Ph-4-0CF3 ch3 Ph-4-F ch3 ch3 Ph+Cl ch3 ch3 Ph-4~Br ch3 ch3 Pii-4 - CF3 ch3 ch3 Ph-4-0CHF2 ch3 ch3 Ph-4-0CF3 ch3 . ch3 Ph+0CF3 ch3 ch3 cf3 Ph-4-C1 ch3 cf3 Ph~4~F ch3 cf3 Ph-4-Cl ch3 cf3 Ph-4-Br ch3 cf3 Ph-4-CF3 ch3 cf3 Ph-4~0CHF： ch3 cf3 Ph-4-0CF3 ch3 Ph-4-F ch3 ch3 Ph-4-Cl ch3 ch3 Ph-4-Br ch3 ch3 Ph-4-CF3 ch3 ch3 Ph-4-0CHF2 ch3 ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-F ch3 cf3 Ph-4-Cl ch3 cf3 Ph-4-Br ch3 cf3 Ph-4-CF3 ch3 cf3 Ph-4-OCHF, 297 314918 200407073 Η CH(CH3)CH2S(0) (L-45a) ch3 cf3 Ph-4-0CF3 Η CH(CH3)CH2S(0)(卜45a) ch3 Ph-4~F ch3 Η CH(CH3)CH2S(0) (L-45a) ch3 Ph-4-C1 ch3 Η CH(CH3)CH2S(0) (L-45a) ch3 Ph-4_Br ch3 Η CH(CH3)CH2S(0) (L-45a) ch3 Ph-4-CF3 ch3 Η CH(CH3)CH2S(0) (L-45a) ch3 Ph-4-0CHF2 ch3 Η CH(CH3)CH2S(0) (L-45a) ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2S02 (L-45a) ch3 cf3 Ph-4-F Η CH (CH3)CH2S02 (L-45a) ch3 cf3 Ph-4-Cl Η CH(CH3)CH2S02 (L-45a) ch3 cf3 Ph-4-Br Η CH(CH3)CH2S02 (L-45a) ch3 cf3 Ph-4-CF3 Η CH(CH3)CH2S02 (L-45a) ch3 cf3 Ph-4-0CHF2 Η CH (CH3)CH2S02(L-45a) ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2S02 (L-45a) ch3 Ph-4-F ch3 Η CH (CH3)CH2S02(L-45a) ch3 Ph+Cl ch3 Η CH(CH3)CH2S02 (L-45a) ch3 Ph-4-Br ch3 Η CH(CH3)CH2S02 (L-45a) ch3 Ph-4-CF3 ch3 Η CH(CH3)CH2S02 (L-45a) ch3 Ph-4-0CHF2 ch3 . Η CH(CH3)CH2S02 (L-45a) ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2S(L-48a) ch3 cf3 Ph+Cl Η CH(CH3)CH2S(0) (L-48a) ch3 Ph-4-0CF3 ch3 Η CH(CH3)CH2S02 (L-48a) ch3 cf3 Ph-4-Cl Η CH (CH3)CH2S(L-48b) ch3 Ph-4-0CF3 ch3 Η CH(CH3)CH2S(0) (L-48b) ch3 cf3 Ph-4-Cl Η CH(CH3)CH2S02 (L-48b) ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2SSCH3 ch3 cf3 Ph-4-F Η CH (CH3)CH2SSCH3 ch3 cf3 Ph-4-Cl Η CH (CH3)CH2SSCH3 ch3 cf3 Ph-4-Br Η CH (CH3)CH2SSCH3 ch3 cf3 Ph+I Η CH (CH3)CH2SSCH3 ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2SSCH3 ch3 cf3 Ph-4-0CHF2 Η CH (CH3)CH2SSCH3 ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2SSCH3 ch3 cf3 Ph-4-0CF2Br Η CH (CH3)CH2SSCH3 ch3 cf3 Ph-4-0CF2CHF2 Η CH (CH3)CH2SSCH3 ch3 cf3 Ph-4-0CF2CHFCF Η CH (CH3)CH2SSCH3 ch3 cf3 Ph-4-CN Η CH (CH3)CH2SSCH3 ch3 cf3 Ph-3, 4-F2
298 314918 200407073 Η CH (CH3)CH2SSCH3 ch3 CF3 Ph - 3-F+Cl Η CH (CH3)CH2SSCH3 ch3 cf3 Ph-3, 4-Cl2 Η CH (CH3)CH2SSCH3 ch3 Ph-4-F ch3 Η CH (CH3)CH2SSCH3 ch3 Ph-4-C1 ch3 Η CH (CH3)CH2SSCH3 ch3 Ph+Br ch3 Η CH (CH3)CH2SSCH3 ch3 Ph+CF3 ch3 Η CH (CH3)CH2SSCH3 ch3 Ph-4_0CHF2 ch3 Η CH (CH3)CH2SSCH3 ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2SSCH3 ch3 Ph-4-0CF2Br ch3 Η CH (CH3)CH2SSCH3 ch3 Ph-4-0CF2CHF2 ch3 Η CH (CH3)CH2SSCH3 ch3 Ph-4-0CF2CHFCF3 ；ch3 Η CH (CH3)CH2SSCH3 ch3 Ph-3,4_C12 ch3 Η CH (CH3)CH2SS(Ph-2-N02) ch3 cf3 Ph+Cl Η CH (Et)CH2SCH3 ch3 Ph-4-0CF3 ch3 Η CH (CH2SCH3) 2 ch3 cf3 Ph-4-C1 Η CH (Ph) CH2SCH3 ch3 Ph-4-0CF3 ch3 Η CH (Ph) CH2S(0) CH3 ch3 cf3 Ph-4-Cl Η CH (Ph) CH2S02CH3 ch3 Ph-4_0CF 3 ch3. Η CH (CH3)CH (CH3)SCH3 ch3 cf3 Ph-4-Cl Η CH (CH3)CH (CH3)S02CH3 ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH (CH3)SEt ch3 cf3 Ph-4-Cl Η CH (CH3)CH (CH3)S02Et ch3 Ph~4~0CF 3 ch3 Η C(CH3) 2ch2sch3 F CF3 Ph-4-F Η c(ch3) 2ch2sch3 F cf3 Ph-4_C1 Η c(ch3) 2ch2sch3 F cf3 Ph-4-Br Η C(CH3) 2ch2sch3 F cf3 Ph-4-0CF3 Η c(ch3)2ch2sch3 F Ph-4-0CF3 ch3 . Η C(CH3) 2ch2sch3 Cl cf3 Ph-4-F Η c(ch3)2ch2sch3 Cl cf3 Ph-4-Cl Η c(ch3)2ch2sch3 Cl cf3 Ph-4-Br Η C(CH3)2CH2SCH3 Cl cf3 Ph+CF3 Η C(CH3) 2ch2sch3 Cl cf3 Ph_4_0CHF 2 Η C(CH3) 2ch2sch3 Cl cf3 Ph+0CF3 Η C(CH3)2CH2SCH3 Cl cf3 Ph-4-CN Η c(ch3) 2ch2sch3 Cl cf3 Ph - 3,4-Cl2 Η C(CH3) 2ch2sch3 Cl Ph-4_F ch3 Η c(ch3)2ch2sch3 Cl Ph-4-Cl ch3 299
314918 200407073
Cl Ph~4*~Br Cl Ph-4-CF3 Cl Ph-4-OCHF Cl Ph-4&gt;0CF3 Br cf3 Br cf3 Br cf3 Br cf3 Br Ph-4-0CF3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 Et ch3 Et ch3 Et ch3 Et ch3 Et ch3 n - Pr ch3 n-Pr ch3 n-Pr ch3 n - Pr ch3 n-Pr H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH0SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 ch3 ch3 ch3 ch3
Ph-4-F
Ph-4-Cl
Ph~4~Br
Ph-4-0CF3 CH3
Ph-4-F
Ph-4-Cl
Ph-4-Br
Ph-4-I
Ph-4-CF3
Ph-4-0CHF2
Ph-4-0CF3
Ph-4-0CF2Br
Ph-4-0CF2CHF2
Ph-4-0CF2CHFCl
Ph-4-0CF2CHFCF3
Ph-4-0CF2CHF0CF3
Ph-4_0CF2CHF0CF2CF2CF
Ph-4~0S02CH3
Ph-4-CN
Ph-3, 4-F2
Ph-3-F-4-Cl
Ph-3, 4-Cl2
Ph~4~F
Ph-4-Cl
Ph-4-Br
Ph-4-CF3
Ph-4-OCF 3
Ph-4-F
Ph-4-Cl
Ph-4-Br
Ph-4-CF3
Ph-4-0CF,
300 314918 200407073 H C(CH3) 2ch2sch3 ch3 i-Pr H C(CH3) 2ch2sch3 ch3 i - Pr H C(CH3) 2ch2sch3 ch3 i-Pr H C(CH3) 2ch2sch3 ch3 i-Pr H C(CH3) 2ch2sch3 ch3 i-Pr H C(CH3) 2ch2sch3 ch3 n-Bu H C(CH3) 2ch2sch3 ch3 chf2 H C(CH3) 2ch2sch3 ch3 chf2 H C(CH3) 2ch2sch3 ch3 chf2 H C(CH3) 2ch2sch3 ch3 chf2 H c(ch3) 2ch2sch3 ch3 chf2 H C(CH3) 2ch2sch3 ch3 chf2 H C(CH3) 2ch2sch3 ch3 chf2 H C(CH3) 2ch2sch3 ch3 chf2 H C(CH3) 2ch2sch3 ch3 chf2 H c(ch3) 2ch2sch3 ch3 chf2 H c(ch3) 2ch2sch3 ch3 chf2 H c(ch3) 2ch2sch3 ch3 chf2 H c(ch3)2ch2sch3 ch3 chf2 H C(CH3) 2ch2sch3 ch3 chf2 H C(CH3) 2ch2sch3 ch3 chf2 H C(CH3) 2ch2sch3 ch3 cf3 H C(CH3) 2ch2sch3 ch3 cf3 H C(CH3) 2ch2sch3 ch3 cf3 H C(CH3) 2ch2sch3 ch3 cf3 H C(CH3) 2ch2sch3 ch3 cf3 H C(CH3) 2ch2sch3 ch3 cf3 H c(ch3) 2ch2sch3 ch3 cf3 H c(ch3) 2ch2sch3 ch3 cf3 H C(CH3) 2ch2sch3 ch3 cf3 H C(CH3) 2ch2sch3 ch3 cf3 H C(CH3) 2ch2sch3 ch3 cf3 H C(CH3) 2ch2sch3 ch3 cf3 H C(CH3)2CH2SCH3 ch3 cf3 H C(CH3) 2ch2sch3 ch3 cf3 H C(CH3) 2ch2sch3 ch3 cf3 H C(CH3) 2ch2sch3 ch3 cf3
Ph-4-F
Ph-4-Cl
Ph+Br
Ph-4-CF3
Ph_4~0CF 3
Ph-4-0CF3
Ph-4-F
Ph-4-Cl
Ph-4-Br
Ph-4-I
Ph-4-CF3
Ph-4-0CHF2 φ
Ph-4-OCFs
Ph-4-0CF2Br
Ph-4~0CF2CHF2
Ph-4-0CF2CHFCF3
Ph-4-0S02CH3
Ph-4-CN .
Ph~3, 4~F2 Ph-3-F*4-Cl Ph - 3,4_C12 Cl Br
n-Pr i-Pr c-Pr n - Bu c - Bu c - Pen c - Hex CH2CH2CF3 CH (CH3)CF3 T-1 T-2 T-3 301 314918 200407073 Η C(CH3) 2ch2sch3 ch3 cf3 T-4 Η C(CH3) 2ch2sch3 ch3 cf3 T-5 Η C(CH3) 2ch2sch3 ch3 cf3 och3 Η c(ch3) 2ch2sch3 ch3 cf3 OEt Η c(ch3) 2ch2sch3 ch3 cf3 OPr-n Η C(CH3) 2ch2sch3 ch3 cf3 OPr-i Η C(CH3) 2ch2sch3 ch3 cf3 OBu-n Η c(ch3) 2ch2sch3 ch3 cf3 OBu-i Η C(CH3) 2ch2sch3 ch3 cf3 OCH2Pr-c Η C(CH3) 2ch2sch3 ch3 cf3 OBu - s Η C(CH3) 2ch2sch3 ch3 cf3 OBu_t Η C(CH3) 2ch2sch3 ch3 cf3 OHex-n Η C(CH3) 2ch2sch3 ch3 cf3 och2cf3 Η C(CH3) 2ch2sch3 ch3 cf3 OCH (CF3) 2 Η C(CH3) 2ch2sch3 ch3 cf3 sch3 Η c(ch3)2ch2sch3 ch3 cf3 SEt Η C(CH3) 2ch2sch3 ch3 cf3 SPr-n Η c(ch3) 2ch2sch3 ch3 cf3 SPr-i Η C(CH3) 2ch2sch3 ch3 cf3 SBu - n Η c(ch3) 2ch2sch3 ch3 cf3 sch2cf3 Η c(ch3) 2ch2sch3 ch3 cf3 SPh Η C(CH3) 2ch2sch3 ch3 cf3 N(CH3)2 Η C(CH3) 2ch2sch3 ch3 cf3 N(CH3)Et Η C(CH3) 2ch2sch3 ch3 cf3 N(Et)2 Η C(CH3) 2ch2sch3 ch3 cf3 C (0) OBu-t Η c(ch3) 2ch2sch3 ch3 cf3 C(0) och2cf3 Η C(CH3) 2ch2sch3 ch3 cf3 T-22 Η C(CH3) 2ch2sch3 ch3 cf3 T-23 Η C(CH3) 2ch2sch3 ch3 cf3 T - 24 Η C(CH3) 2ch2sch3 ch3 cf3 Ph Η c(ch3) 2ch2sch3 ch3 cf3 Ph-2-F Η c(ch3)2ch2sch3 ch3 cf3 Ph-3-F Η c(ch3)2ch2sch3 ch3 cf3 Ph-4-F Η C(CH3)2CH2SCH3 ch3 cf3 Ph+Cl Η C(CH3)2CH2SCH3 ch3 CFa Ph-4-C1 Η c(ch3)2ch2sch3 ch3 cf3 Ph-4-Br Η C(CH3)2CH2SCH3 ch3 cf3 Ph-4-I 302
314918 200407073
H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H c(ch3)2ch2sch3 ch3 CF H c(ch3) 2ch2sch3 ch3 CF H c(ch3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H c(ch3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H c(ch3) 2ch2sch3 ch3 CF H c(ch3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H c(ch3) 2ch2sch3 ch3 CF H c(ch3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H c(ch3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H c(ch3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF
Ph-4-CF3 Ph-4-CH2SCH3 Ph-4-CH2SCF3 Ph-4-0CHF2 Ph-4-OCFs Ph-4-0CF2Br Ph+0CH2CF3 Ph-4-0CF2CHF2 Ph-4-0CF2CHFC1 Ph-4-0CF2CHFBr Ph-4-0CF2CF2Br
Ph-4-0CF2CFCl2 ·
Ph-4-0CF2CCl3
Ph-4-0CH2CF2CHF2
Ph-3_0CF2CHFCF3
Ph-4-0CF2CHFCF3
Ph-4-0CH(CF3) 2
Ph-4~0CF2CFBrCF3
Ph-3-0CF2CHF0CF3
Ph-4-0CF2CHF0CF3
Ph-4-0CF2CHF0CF2CF2CF3
Ph-4-0S02CH3
Ph-4-0S02CF3
Ph-4-0(L-45g) 麄
Ph-4-0 (L-451) ™
Ph-4-SCH3
Ph-4-S02CH3
Ph-4-N02
Ph-4-CN
Ph-2, 3-F2
Ph-2,4-F2
Ph-2,5~F2
Ph-3,4-F2
Ph-3,5-F2
Ph_2-C1-4_F
Ph-2-F-3-C1
Ph - 3-C1+F 303 314918 200407073
Η C(CH3)2CH2SCH3 ch3 cf3 Ph-2-F-4-Cl Η C(CH3) 2ch2sch3 ch3 cf3 Ph^3~F_4~C1 Η C(CH3) 2ch2sch3 ch3 cf3 Ph-2,3-Cl2 Η C(CH3) 2ch2sch3 ch3 cf3 Ph-2,4-Cl2 Η C(CH3) 2ch2sch3 ch3 cf3 Ph-2,5-Cl2 Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3,4-Cl2 Η c(ch3) 2ch2sch3 ch3 cf3 Ph-3,5-Cl2 Η C(CH3) 2ch2sch3 ch3 cf3 Ph_3_Br-4_F Η C(CH3) 2ch2sch3 ch3 cf3 Ph-2-F-4-Br Η C(CH3) 2ch2sch3 ch3 cf3 Ph-2-F-5-Br Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3, 4-Br2 Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3,5-Βγ2 Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3-CH3-4-F Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3~F_4-CH3 Η C(CH3) 2CH0SCH3 ch3 cf3 Ph-2-F-5-CH3 Η C(CH3) 2CH2SCH3 ch3 cf3 Ph-2, 4- (CH3)2 Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3,4-(CH3)2 Η c(ch3)2ch2sch3 ch3 cf3 Ph-2-F - 3-CF3. Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3-CF3-4-F Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3-CF3-4-Cl Η C(CH3) 2ch2sch3 ch3 cf3 Ph-2-F-4-CF3 Η C(CH3) 2ch2sch3 ch3 cf3 Ph**3-F-4 - CF3 Η c(ch3) 2ch2sch3 ch3 cf3 Ph_2-F-5-CF3 Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3-F-5-CF3 Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3,5- (CF3) 2 Η C(CH3) 2ch2sch3 ch3 cf3 Ph_3-Br-4_0CH3 Η c(ch3) 2ch2sch3 ch3 cf3 Ph-3-F-4-0CHF2 Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3~Cl-4-0CHF2 Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3-Br-4-0CHF2 Η C(CH3) 2ch2sch3 ch3 cf3 Ph~3~F~4-0CF 3 Η c(ch3) 2ch2sch3 ch3 cf3 Ph-3-Cl-4-0CF3 Η c(ch3) 2ch2sch3 ch3 gf3 Ph-3-Br-4-0CF3 Η c(ch3) 2ch2sch3 ch3 cf3 Ph-3-F-4-0CF2Br Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3-CH-0CF2Br Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3-Br-4-OCF 2Br Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3-F-4-0CF2CHF2 Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3-C卜4-0CF2CHF
304 314918 200407073 H C(CH3) 2ch2sch3 ch3 CF, H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF, H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H c(ch3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H c(ch3) 2ch2sch3 ch3 CF； H c(ch3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF, H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF； H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF, H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF, H c(ch3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF, H C(CH3) 2ch2sch3 ch3 CF H c(ch3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H c(ch3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF H C(CH3) 2ch2sch3 ch3 CF 305
Ph-3-Br-4-0CF2CHF2 Ph-3-F-4-0CF2CHFCl Ph-3-C卜4-0CF2CHFC1 Ph-3-Br_4-0CF2CHFCf Ph-3-F-4-0CF2CHFCF3 Ph-3-Cl-4-0CF2CHFCF3 Ph-3-Br-4-0CF2CHFCF3 Ph-3-F-4-0CF2CHF0CF3 Ph-3-Cl-4-0CF2CHF0CF3 Ph-3-Br-4-0CF2CHF0CF3 Ph_3-F-4-OCF 2 CHFOCF 2 CF 2 CF 3 Ph-3 - C 卜4-OCF 2 C_CF 2 CF 2 CF 3 ·
Ph-3-Br-4-0CF2CHF0CF2CF2CF3 Ph(-3-0CF20-4-）
Ph (-3-0CF2CF20-4-）
Ph-3-0Ph-4-F Ph-3-N02-4-F Ph-3-N02-4-Cl Ph-2_F-5-N02 Ph-3-CN-4-F Ph-2, 3, 4-F3 Ph-2, 3,5-F3 Ph-2, 4,5-F3
Ph-3, 4,5-F3 φ
Ph-2, 3-F2-4-CH3 Ph-2,3-F2-4-CF3 Ph-3, 4-F2_5_CF3 Ph_2-F-3-C1-5-CF 3 1- Naph 2- Naph L-lb L~lc L - Id L - le L-li L - 2b 314918 200407073 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 Ή C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 ch3 cf3 L-3b ch3 cf3 L-3c ch3 cf3 L-3d ch3 cf3 L - 3e ch3 cf3 L-3f ch3 cf3 L - 3j ch3 cf3 L - 3k ch3 cf3 L-31 ch3 cf3 L-3o ch3 cf3 L - 4b ch3 cf3 L-4c ch3 cf3 L-4e ch3 cf3 L - 10b ch3 cf3 L - 10c ch3 cf3 L-14b ch3 cf3 L - 14c ch3 cf3 L-14d ch3 cf3 L-14e ch3 cf3 L - 14f ch3 cf3 L - 14g ch3 cf3 L- 14h ch3 cf3 L- 16a ch3 CF3 L- 16b ch3 cf3 L-17a ch3 cf3 L-21b ch3 cf3 L-21c ch3 cf3 L-21d ch3 cf3 L~21e ch3 cf3 L-22b ch3 cf3 L_22c CHa cf3 L - 23b ch3 cf3 L-23c ch3 cf3 L-23i ch3 cf3 L - 23g ch3 cf3 L-24b ch3 cf3 L - 24c
306 314918 200407073 Η C(CH3) 2ch2sch3 ch3 cf3 L-24d Η C(CH3) 2ch2sch3 ch3 cf3 L - 24e Η C(CH3) 2ch2sch3 ch3 cf3 L-31a Η C(CH3) 2ch2sch3 ch3 cf3 L-31b Η c(ch3)2ch2sch3 ch3 cf3 L-36b Η C(CH3) 2ch2sch3 ch3 cf3 L - 36c Η C(CH3)2CH2SCH3 ch3 cf3 L - 36d Η C(CH3) 2ch2sch3 ch3 cf3 L - 45c Η C(CH3) 2ch2sch3 ch3 cf3 L - 45d Η C(CH3) 2ch2sch3 ch3 cf3 L-45e Η C(CH3) 2ch2sch3 ch3 cf3 L-45f Η C(CH3) 2ch2sch3 ch3 cf3 L-45g Η C(CH3) 2ch2sch3 ch3 cf3 L-45m Η C(CH3) 2ch2sch3 ch3 cf3 L - 46c Η C(CH3) 2ch2sch3 ch3 cf3 L - 46d Η C(CH3) 2ch2sch3 ch3 cf3 L - 46e Η C(CH3) 2ch2sch3 ch3 cf3 L-46f Η c(ch3)2ch2sch3 ch3 cf3 L - 46g Η C(CH3) 2ch2sch3 ch3 cf3 L-46j Η C(CH3) 2ch2sch3 ch3 cf3 L-46k Η C(CH3) 2ch2sch3 ch3 cf3 L - 46r Η C(CH3) 2ch2sch3 ch3 cf3 L - 47a Η C(CH3) 2ch2sch3 ch3 CF3 L - 48b Η C(CH3)2CH2SCH3 ch3 cf3 L - 50b Η C(CH3) 2ch2sch3 ch3 cf3 L - 50c Η C(CH3) 2ch2sch3 ch3 cf3 L - 50d Η C(CH3) 2ch2sch3 ch3 cf3 L-51b Η C(CH3) 2ch2sch3 ch3 cf2ci Ph-4-F Η C(CH3) 2ch2sch3 ch3 cf2ci Ph+Cl Η C(CH3) 2ch2sch3 ch3 cf2ci Ph-4~Br Η C(CH3) 2ch2sch3 ch3 cf2ci Ph+CF3 Η c(ch3) 2ch2sch3 ch3 cf2ci Ph-4-OCHF Η C(CH3) 2ch2sch3 ch3 cf2ci Ph-4-0CF3 Η C(CH3) 2ch2sch3 ch3 cf2ci Ph+CN Η C (CH3) 2ch2sch3 ch3 cf2ci Ph-3,4-Cl Η C(CH3) 2ch2sch3 ch3 CF2Br Ph_4_Cl 200407073 Η C(CH3) 2ch2sch3 ch3 cf2chf2 Ph-4-Br Η c(ch3)2ch2sch3 ch3 cf2cf3 Ph-4-F Η C(CH3) 2ch2sch3 ch3 cf2cf3 Ph-4-Cl Η c(ch3) 2ch2sch3 ch3 cf2cf3 Ph-4-Br Η C(CH3) 2ch2sch3 ch3 cf2cf3 Ph-4-I Η c(ch3) 2ch2sch3 ch3 cf2cf3 Ph-4-CF3 Η C(CH3) 2ch2sch3 ch3 cf2cf3 Ph-4-0CHF2 Η C(CH3) 2ch2sch3 ch3 cf2cf3 Ph-4-0CF3 Η C(CH3) 2ch2sch3 ch3 cf2cf3 Ph-4_0CF2Br Η C(CH3) 2ch2sch3 ch3 cf2cf3 Ph-4-0CF2CHF2 Η C(CH3) 2ch2sch3 ch3 cf2cf3 Ph-4-0CF2CHFCF Η C(CH3) 2ch2sch3 ch3 cf2cf3 Ph-4-CN Η C(CH3) 2ch2sch3 ch3 cf2cf3 Ph-3, 4-F2 Η C(CH3)2CH2SCH3 ch3 cf2cf3 Ph-3_F-4-C1 Η c(ch3) 2ch2sch3 ch3 cf2cf3 Ph-3,4-Cl2 Η C(CH3)2CH2SCH3 ch3 cf2cf2ci Ph-4-0CF3 Η C(CH3) 2ch2sch3 ch3 CFC1CF3 Ph-4-Cl Η c(ch3)2ch2sch3 ch3 CFC1CF2C1 Ph-4-Br . Η C(CH3) 2ch2sch3 ch3 cf2cf2cf3 Ph-4-0CF3 Η C(CH3) 2ch2sch3 ch3 cf(cf3)2 Ph-4-C1 Η C(CH3) 2ch2sch3 ch3 cf2cf2cf2cf3 Ph-4-Br Η c(ch3)2ch2sch3 ch3 Ph ch3 Η C(CH3) 2ch2sch3 ch3 Ph-2-F ch3 Η c(ch3)2ch2sch3 ch3 Ph-3_F ch3 Η c(ch3)2ch2sch3 ch3 Ph-4-F ch3 Η C(CH3) 2ch2sch3 ch3 Ph-4-F Ph+Cl Η C(CH3) 2ch2sch3 ch3 Ph-4-Cl ch3 Η C(CH3) 2ch2sch3 ch3 Ph-4-Cl Ph-4-Cl Η c(ch3) 2ch2sch3 ch3 Ph~4~Br ch3 Η c(ch3)2ch2sch3 ch3 Ph+Br Ph-4-Cl Η C(CH3) 2ch2sch3 ch3 Ph+CF3 ch3 Η c(ch3) 2ch2sch3 ch3 Ph+CF3 Ph-4-Cl Η c(ch3) 2ch2sch3 ch3 Ph-4-0CHF2 ch3 Η C(CH3)2CH2SCH3 ch3 Ph-4-0CF3 Cl Η C(CH3) 2ch2sch3 ch3 Ph-4-0CF3 ch3 Η C(CH3) 2ch2sch3 ch3 Ph-4-0CF3 cf3 Η c(ch3) 2ch2sch3 ch3 Ph - 4-0C.F3 och3 308
314918 200407073 H C(CH3)2CH2SCH3 Η C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3‘ H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 ch3 Ph-4-OCF 3 OCH2CF3 ch3 Ph-4-0CF3 sch3 ch3 PlHhOCF3 n(ch3)2 ch3 Ph-4-0CF3 Ph_4_Cl ch3 Ph~4_0CF2Br Cl ch3 Ph-4-OCF2Br ch3 ch3 Ph-4-0CF2Br 〇CH3 ch3 Ph-4-0CH2CF3 ch3 ch3 Ph-4-OCF2CHF2 ch3 ch3 Ph-4-0CF2CHFCl ch3 ch3 Ph-4-0CF2CHFBr ch3 ch3 Ph-4-0CF2CF2Br ch3 ch3 Ph-4-0CF2CFCl2 ch3 ch3 Ph-4-0CF2CHFCF3 Cl ch3 Ph-4-0CF2CHFCF3 ch3 ch3 PtHhOCF2CHFCF3 och3 ch3 Ph-4-OCH (CF3) 2 ch3 ch3 Ph-4-0CF2CFBrCF3 ch3. ch3 Ph-4-0CF2CHF0CF3 ch3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 Cl ch3 Ph-4-0CF2CHF0CF2CF2CF3 ch3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 och3 ch3 Ph-4-0S02CH3 ch3 ch3 Ph-4 - 0(L-45g) ch3 ch3 Ph-4-0 (L-451) ch3 ch3 Ph-4-SCH3 ch3 ch3 Ph-4-S〇2 CH3 ch3 ch3 Ph-4-CN ch3 ch3 Ph-3, 4-F2 ch3 ch3 Ph-3-F-4-C1 ch3 ch3 Ph~3, 4_C12 ch3 ch3 L-lc ch3 ch3 L - Id ch3 ch3 L-le ch3 ch3 L-li ch3 ch3 L-2b ch3 ch3 L-3c ch3
309 314918 200407073
Η C(CH3) 2ch2sch3 ch3 L-3d ch3 Η C(CH3) 2ch2sch3 ch3 L - 3e ch3 Η C(CH3) 2ch2sch3 ch3 L-3i ch3 Η C(CH3) 2ch2sch3 ch3 L - 3k ch3 Η C(CH3) 2ch2sch3 ch3 L-31 ch3 Η C(CH3) 2ch2sch3 ch3 L - 3o ch3 Η C(CH3) 2ch2sch3 ch3 L-4b ch3 Η C(CH3) 2ch2sch3 ch3 L-4c ch3 Η C(CH3) 2ch2sch3 ch3 L - 45d ch3 Η C(CH3) 2ch2sch3 ch3 L-45e ch3 Η C(CH3) 2ch2sch3 ch3 L-45i ch3 Η C(CH3) 2ch2sch3 ch3 L-45g ch3 Η C(CH3) 2ch2sch3 ch3 L - 45m ch3 Η C(CH3) 2ch2sch3 ch3 L-46d ch3 Η C(CH3) 2ch2sch3 ch3 L - 46e ch3 Η c(ch3) 2ch2sch3 ch3 L-46f ch3 Η C(CH3) 2ch2sch3 ch3 L-46g ch3 Η C(CH3) 2ch2sch3 ch3 L-46j ch3. Η C(CH3) 2ch2sch3 ch3 L - 46k ch3 Η C(CH3) 2ch2sch3 ch3 L-46r ch3 Η C(CH3) 2ch2sch3 ch3 L - 47a ch3 Η C(CH3) 2ch2sch3 ch3 L-47e ch3 Η c(ch3) 2ch2sch3 Et cf3 Ph-4-C1 Η C(CH3) 2CH2S(0) ch3 ch3 ch3 Ph-4-F Η c(ch3) 2ch2s(o)ch3 ch3 ch3 Ph-4-Cl Η C(CH3) 2CH2S(0) ch3 ch3 ch3 Ph-4-Br Η C(CH3) 2CH2S(0) ch3 ch3 ch3 Ph-4_CF3 Η C(CH3) 2CH2S(0) ch3 ch3 ch3 Ph-4-0CHF Η C(CH3) 2CH2S(0) ch3 ch3 ch3 Ph-4-OCFs Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-4-F Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-4-Cl Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-4-Br Η c(ch3)2ch2s(o)ch3h ch3 cf3 Ph-4-Br Η C(CH3)2CH2S(0) ch3(+) ch3 cf3 Ph~4~Br Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-4-I Η C(CH3)2CH2S(0) ch3 ch3 cf3 Ph-4-CF3 Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-4-0CHF
310 314918 200407073 Η c(ch3)2ch2s(o)ch3 ch3 cf3 Ph-4-0CF3 Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-4-0CF2Br Η c(ch3) 2ch2s(o)ch3 ch3 cf3 Ph-4-0CF2CHF2 Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-4-0CF2CHFCl Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-4_0CF2CHFBr Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-4-0CF2CF2Br Η c(ch3) 2ch2s_3 ch3 cf3 Ph-4-0CF2CFC12 Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-4-0CF2CC13 Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-4-0CF2CHFCF3 Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-4-OCH (CF3) 2 Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-4-0CF2CFBrCF3 Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-4-0CF2CHF0CF3 Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-4-0CF2CHF0CF2CF2CF3 Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-4-0 (L-45g) Η c(ch3) 2ch2s(o)ch3 ch3 cf3 Ph - 4-0(L - 451) Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Pli - 4-S02CH3 Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-4-CN Η C(CH3)2CH2S(0) ch3 ch3 cf3 Ph - 3,4-F2 . Η C(CH3) 2CH2S(0) ch3 ch3 cf3 Ph-3-F-4-Cl Η C(CH3)2CH2S(0) ch3 ch3 cf3 Ph-3,4-Cl2 Η C(CH3)2CH2S(0) ch3 ch3 cf3 L-45d Η C(CH3) 2CH2S(0) ch3 ch3 cf3 L-45e Η C(CH3) 2CH2S(0) ch3 ch3 cf3 L-45f Η C(CH3)2CH2S(0) ch3 ch3 cf3 L-45g Η C(CH3) 2CH2S(0) ch3 ch3 cf3 L-45m Η C(CH3) 2CH2S(0) ch3 ch3 cf3 L-46d Η C(CH3) 2CH2S(0) ch3 ch3 cf3 L-46e Η C(CH3) 2CH2S(0) ch3 ch3 cf3 L-46f Η C(CH3)2CH2S(0) ch3 ch3 cf3 L_46g Η C(CH3) 2CH2S(0) ch3 ch3 cf3 L - 46j Η c(ch3)2ch2s(o)ch3 ch3 cf3 L-46k Η C(CH3) 2CH2S(0) ch3 ch3 cf3 L-46r Η c(ch3) 2ch2s(o)ch3 ch3 Ph-4-F ch3 Η C(CH3)2CH2S(0)CH3 ch3 Ph-4-F Ph-4-Cl Η C(CH3)2CH2S(0) ch3 ch3 Ph-4_C1 ch3 Η C(CH3) 2CH2S(0) ch3 ch3 Pli - 4_C 1 Ph+Cl Η C(CH3) 2CH2S(0) ch3 ch3 Pii - 4-Br ch3 311 314918 200407073 H C(CH3) 2CH2S(0)CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 ch3 Ph-4-Br Ph+Cl ch3 Ph-4-CF3 ch3 ch3 Ph+CF3 Ph+Cl ch3 Ph-4_0CHF2 ch3 ch3 Ph-4-0CF3 Cl ch3 Ph-4-0CF3 ch3 ch3 Ph-4-0CF3 cf3 ch3 Ph+0CF3 0CH3 ch3 Ph-4-0CF3 och2cf3 ch3 Ph-4-0CF3 sch3 ch3 Ph-4-0CF3 _3)2 ch3 Ph-4-0CF3 Ph-4-Cl ch3 Ph-4-0CF2Br Cl ch3 Ph-4-0CF2Br ch3 ch3 Ph-4-0CF2Br 〇CH3 ch3 Ph-4-0CH2CF3 ch3 ch3 Ph-4-0CF2CHF2 ch3 ch3 Ph-4-0CF2CHFCl ch3. ch3 Ph-4-0CF2CHFBr ch3 ch3 Ph-4-0CF2CF2Br ch3 ch3 Ph-4-0CF2CFCl2 ch3 ch3 Ph-4-0CF2CHFCF3 Cl ch3 Ph-4-0CF2CHFCF3 ch3 ch3 Ph-4-0CF2CHFCF3 och3 ch3 Ph-4-0CH(CF3) 2 ch3 ch3 Ph-4-0CF2CFBrCF3 ch3 ch3 Ph-4-0CF2CHF0CF3 ch3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 Cl ch3 Ph-4-0CF2CHF0CF2CF2CF3 ch3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 och3 ch3 Ph - 4-0 (L-45g) ch3 ch3 Ph-4-0 (L-451) ch3 ch3 Ph-4-S02CH3 ch3 ch3 Ph+CN ch3 ch3 Ph-3,4-F2 ch3 ch3 Ph-3-F-4-。1 ch3 ch3 Ph-3, 4-Cl2 ch3
312 314918 200407073 Η C(CH3) 2ch2so2ch3 ch3 ch3 Ph-4_F Η C(CH3) 2ch2so2ch3 ch3 ch3 Ph+Cl Η c(ch3) 2ch2so2ch3 ch3 ch3 Ph-4-Br Η C(CH3) 2ch2so2ch3 ch3 ch3 Ph~4~I Η C(CH3) 2ch2so2ch3 ch3 ch3 Ph-4-CF3 Η C(CH3) 2ch2so2ch3 ch3 ch3 Ph-4-0CHF2 Η C(CH3) 2ch2so2ch3 ch3 ch3 Ph-4-0CF3 Η C(CH3) 2ch2so2ch3 ch3 ch3 Ph-4-0CF2Br Η C(CH3) 2ch2so2ch3 ch3 ch3 Ph-4-0CF2CHF2 Η C(CH3) 2ch2so2ch3 ch3 ch3 Ph-4_0CF2CHFC1 Η c(ch3) 2ch2so2ch3 ch3 ch3 Ph-4-0CF2CHFCF3 Η C(CH3) 2ch2so2ch3 ch3 ch3 Ph-4-0CF2CHF0CF3 Η c(ch3) 2ch2so2ch3 ch3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 Η C(CH3) 2ch2so2ch3 ch3 ch3 Ph-4-0S02CH3 Η C(CH3) 2ch2so2ch3 ch3 ch3 Ph-4-CN Η C(CH3) 2ch2so2ch3 ch3 ch3 Ph-3, 4-F2 Η C(CH3) 2ch2so2ch3 ch3 ch3 Ph-3-F-4-Cl Η C(CH3) 2ch2so2ch3 ch3 ch3 Ph-3,4_C12 . Η C(CH3) 2ch2so2ch3 ch3 Et Ph-4-F Η C(CH3) 2ch2so2ch3 ch3 Et Ph-4-Cl Η C(CH3) 2ch2so2ch3 ch3 Et Ph_4-Br Η C(CH3) 2ch2so2ch3 ch3 Et Ph-4-CF3 Η C(CH3) 2ch2so2ch3 ch3 Et Ph-4-0CHF2 Η C(CH3) 2ch2so2ch3 ch3 Et Ph-4-0CF3 Η C(CH3) 2ch2so2ch3 ch3 Et Ph-4-CN Η C(CH3) 2ch2so2ch3 ch3 Et Ph-3,4-Cl2 Η C(CH3) 2ch2so2ch3 ch3 n-Pr Ph-4-0CF3 Η C(CH3) 2ch2so2ch3 ch3 i-Pr Ph-4-Cl Η C(CH3) 2ch2so2ch3 ch3 n-Bu Ph-4_Br Η C(CH3) 2ch2so2ch3 ch3 chf2 Ph-4-F Η C(CH3) 2ch2so2ch3 ch3 chf2 Ph+Cl Η C(CH3) 2ch2so2ch3 ch3 chf2 Ph-4-Br Η c(ch3) 2ch2so2ch3 ch3 chf2 Ph+CF3 Η C(CH3) 2ch2so2ch3 ch3 chf2 Ph-4-0CHF2 Η C(CH3) 2ch2so2ch3 ch3 chf2 Ph-4-0CF3 Η C(CH3) 2ch2so2ch3 ch3 chf2 Ph-4-CN Η C(CH3) ,ch2so2ch3 ch3 chf2 Ph-3,4-Cl2 Ο 1 Λ j Ιο Π4918 200407073
H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H c(ch3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H c(ch3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H c(ch3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H c(ch3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H c(ch3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H c(ch3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF H C(CH3) 2ch2so2ch3 ch3 CF
Cl
Br ch3
Et i - Pr c-Pr 0CH3 OEt OPr - n OPr-i OBu-n SCH3 # SEt SPr - n SPr-i N(CH3) 2
Ph-4-F
Ph-4-C1 .
Ph-4-Br Ph-4-I Ph-4-CF3 Ph-4-0CHF2 Ph-4-0CF3
Ph-4-0CF2Br a
Ph-4-0CF2CHF2
Ph-4-0CF2CHFCl
Ph-4_0CF2CHFCF3
Ph-4-0CF2CHF0CF3
Ph-4-0CF2CHF0CF2CF2CF3
Ph-4-0S02CH3
Ph-4-0 (L-45g)
Ph-4-0(L-451)
Ph-4-SCH3 Ph-4-S02CH3 Ph-4-CN Ph-3, 4-F2 Ph~3~F-4~Cl 314 314918 200407073 Η C(CH3) 2ch2so2ch3 ch3 cf3 Ph-3, 4-Cl2 Η C(CH3) 2ch2so2ch3 ch3 cf3 L-lb Η C(CH3) 2ch2so2ch3 ch3 cf3 L-lc Η C(CH3) 2ch2so2ch3 ch3 cf3 L-le Η c(ch3) 2ch2so2ch3 ch3 cf3 L- li Η c(ch3) 2ch2so2ch3 ch3 cf3 L-2b Η C(CH3) 2ch2so2ch3 ch3 cf3 L-3b Η C(CH3) 2ch2so2ch3 ch3 cf3 L-3c Η C(CH3) 2ch2so2ch3 ch3 cf3 L-3d Η C(CH3) 2ch2so2ch3 ch3 cf3 L - 3f Η C(CH3) 2ch2so2ch3 ch3 cf3 L-3j Η C(CH3) 2ch2so2ch3 ch3 cf3 L-3k Η C(CH3) 2ch2so2ch3 ch3 cf3 L-31 Η C(CH3) 2ch2so2ch3 ch3 cf3 L-4b Η C(CH3)2CH2S02CH3 ch3 cf3 L - 4c Η C(CH3) 2ch2so2ch3 ch3 cf3 L-4e Η C(CH3) 2ch2so2ch3 ch3 cf3 L-lOb Η c(ch3)2ch2so2ch3 ch3 cf3 L-lOc Η C(CH3) 2ch2so2ch3 ch3 cf3 L-14b Η C(CH3)2CH2S02CH3 ch3 cf3 L-14c Η C(CH3) 2ch2so2ch3 ch3 cf3 L-14d Η C(CH3) 2ch2so2ch3 ch3 cf3 L- 14e Η c(ch3) 2ch2so2ch3 ch3 cf3 L-14f Η C(CH3) 2ch2so2ch3 ch3 CFs L-14h Η C(CH3) 2ch2so2ch3 ch3 cf3 L-16a Η c(c.h3) 2ch2so2ch3 ch3 cf3 L-16b Η C(CH3) 2ch2so2ch3 ch3 cf3 L - 17a Η C(CH3) 2ch2so2ch3 ch3 cf3 L-21b Η C(CH3) 2ch2so2ch3 ch3 cf3 L-21c Η C(CH3) 2ch2so2ch3 ch3 CFs L - 21e Η C(CH3) 2ch2so2ch3 ch3 cf3 L - 22b Η C(CH3) 2ch2so2ch3 ch3 cf3 L - 22c Η c(ch3)2ch2so2ch3 ch3 cf3 L-23b Η c(ch3)2ch2so2ch3 ch3 cf3 L-23c Η C(CH3) 2ch2so2ch3 ch3 cf3 L - 23i Η c(ch3)2ch2so2ch3 ch3 cf3 L-23g Η C(CH3) 2ch2so2ch3 ch3 cf3 L - 24b
315 314918 200407073 Η C(CH3) 2ch2so2ch3 ch3 cf3 L-24c Η C(CH3) 2ch2so2ch3 CHa cf3 L-24e Η C(CH3)2CH2S02CH3 ch3 cf3 L - 31a Η C(CH3) 2ch2so2ch3 ch3 cf3 L-31b Η C(CH3) 2ch2so2ch3 ch3 cf3 卜36b Η c(ch3)2ch2so2ch3 ch3 cf3 L - 36c Η C(CH3) 2ch2so2ch3 ch3 cf3 L-36d Η C(CH3) 2ch2so2ch3 ch3 cf3 L-45c Η c(ch3)2ch2so2ch3 ch3 cf3 L_45d Η c(ch3)2ch2so2ch3 ch3 cf3 L-45e Η c(ch3) 2ch2so2ch3 ch3 cf3 L-45f Η C(CH3) 2ch2so2ch3 ch3 cf3 L - 45g Η C(CH3) 2ch2so2ch3 ch3 cf3 L-45m Η c(ch3)2ch2so2ch3 ch3 cf3 L-46c Η C(CH3) 2ch2so2ch3 ch3 cf3 L-46d Η c(ch3)2ch2so2ch3 ch3 cf3 L_46e Η c(ch3) 2ch2so2ch3 ch3 cf3 L-46f Η C(CH3)2CH2S02CH3 ch3 cf3 L-46g Η C(CH3) 2ch2so2ch3 ch3 cf3 L - 46j Η C(CH3) 2ch2so2ch3 ch3 cf3 L-46k Η C(CH3) 2ch2so2ch3 ch3 •cf3 L - 46r Η C(CH3)2CH2S02CH3 ch3 cf3 L - 47a Η C(CH3) 2ch2so2ch3 ch3 cf3 L-48b Η c(ch3)2ch2so2ch3 ch3 CFs L-50b Η c(ch3)2ch2so2ch3 ch3 cf3 L-50c Η C(CH3) 2ch2so2ch3 ch3 cf3 L-51b Η c(ch3) 2ch2so2ch3 ch3 cf2ci Ph-4-F Η c(ch3)2ch2so2ch3 ch3 cf2ci Ph-4-Cl Η C(CH3)2CH2S02CH3 ch3 cf2ci Ph-4-Br Η C(CH3)2CH2S02CH3 ch3 cf2ci Ph~4~CF 3 Η C(CH3)2CH2S02CH3 ch3 cf2ci Ph-4-OCHF Η c(ch3)2ch2so2ch3 ch3 cf2ci Ph_4-0CF3 Η c(ch3)2ch2so2ch3 ch3 cf2ci Ph-4-CN Η C(CH3)2CH2S02CH3 ch3 cf2ci Ph-3, 4-Cl Η c(ch3)2ch2so2ch3 ch3 CF2Br Ph-4-OCFa Η c(ch3)2ch2so2ch3 ch3 cf2cf3 Ph-4-F Η c(ch3)2ch2so2ch3 ch3 cf2cf3 Ph-4-Cl
316 314918 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 c(ch3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 c(ch3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 c(ch3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 c(ch3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 c(ch3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so〇ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 C(CH3) 2ch2so2ch3 ch3 cf2cf3 Ph-4-Br ch3 cf2cf3 Ph_4-CF3 ch3 cf2cf3 Ph-4-OCHF ch3 cf2cf3 Ph-4-0CF3 ch3 cf2cf3 Ph-4-CN ch3 cf2cf3 Ph-3, 4-C1 ch3 CF2CF2CF3 Ph+Cl ch3 Ph-4-F ch3 ch3 Ph-4-F Ph-4-Cl ch3 Ph-4-Cl ch3 ch3 Ph-4-Cl Ph-4-Cl ch3 Ph-4-Br ch3 ch3 Ph-4~Br Ph-4-Cl ch3 Ph-4-CF3 ch3 ch3 Ph+CF3 Ph-4-Cl ch3 Ph-4-0CHF2 ch3 ch3 Ph-4-0CF3 Cl ch3 Ph-4~0CF 3 ch3. ch3 Ph-4-OCF3 cf3 ch3 Ph-4-OCF3 och3 ch3 Ph-4-0CF3 och2cf3 ch3 Ph-4-0CF3 sch3 ch3 Ph-4-0CF3 n(ch3)2 ch3 Ph-4-OCF3 Ph-4-Cl ch3 Ph-4-0CF2Br Cl ch3 Ph-4-0CF2Br ch3 ch3 Ph-4_0CF2Br och3 ch3 Ph-4-0CH2CF3 ch3 ch3 Ph-4_0CF2CHF2 ch3 ch3 Ph-4-0CF2CHFCl ch3 ch3 Ph-4-0CF2CHFBr ch3 ch3 Ph-4~0CF2CF2Br ch3 ch3 Ph-4-0CF2CFCl2 ch3 ch3 Ph-4-0CF2CHFCF3 Cl ch3 Ph-4-0CF2CHFCF3 ch3 ch3 Ph-4_0CF2CHFCF3 och3 ch3 Ph-4-0CH (CF3) 2 ch3
317 314918 200407073 Η c(ch3)2ch2so2ch3 ch3 Ph-4-0CF2CFBrCF3 ch3 Η C(CH3) 2ch2so2ch3 ch3 Ph-4-0CF2CHF0CF3 ch3 Η C(CH3)2CH2S02CH3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 Cl Η c(ch3)2ch2so2ch3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 ch3 Η c(ch3)2ch2so2ch3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 och3 Η c(ch3)2ch2so2ch3 ch3 Ph-4-0 (L-45g) ch3 Η c(ch3)2ch2so2ch3 ch3 Ph - 4-0(L - 451) ch3 Η c(ch3) 2ch2so2ch3 ch3 Ph-4_S02CH3 ch3 Η C(CH3)2CH2S02CH3 ch3 Ph-4-CN ch3 Η c(ch3)2ch2so2ch3 ch3 Ph-3,4-F2 ch3 Η C(CH3)2CH2S02CH3 ch3 Ph-3-F-4-Cl ch3 Η C(CH3) 2ch2so2ch3 ch3 Ph-3,4-Cl2 ch3 Η C(CH3) 2ch2so2ch3 ch3 L~ lc ch3 Η c(ch3)2ch2so2ch3 ch3 L - Id ch3 Η C(CH3)2CH2S02CH3 ch3 L-le ch3 Η C(CH3) 2ch2so2ch3 ch3 L-li ch3 Η C(CH3) 2ch2so2ch3 ch3 L-2b ch3 Η C(CH3)2CH2S02CH3 ch3 L~3c ch3 . Η c(ch3)2ch2so2ch3 ch3 L - 3d ch3 Η c(ch3)2ch2so2ch3 ch3 L - 3e ch3 Η C(CH3) 2ch2so2ch3 ch3 L-3f ch3 Η c(ch3)2ch2so2ch3 ch3 L-3k ch3 Η C(CH3) 2ch2so2ch3 ch3 L-31 ch3 Η C(CH3) 2ch2so2ch3 ch3 L~3o ch3 Η C(CH3) 2ch2so2ch3 ch3 L-4b ch3 Η C(CH3) 2ch2so2ch3 ch3 L - 4c ch3 Η C(CH3) 2ch2so2ch3 ch3 L-45d ch3 Η c(ch3) 2ch2so2ch3 ch3 L-45e ch3 Η C(CH3)2CH2S02CH3 ch3 L-45f ch3 Η C(CH3) 2ch2so2ch3 ch3 L-45g ch3 Η C(CH3) 2ch2so2ch3 ch3 L-4〇m ch3 Η C(CH3) 2ch2so2ch3 ch3 L-偏 ch3 Η C(CH3) 2ch2so2ch3 ch3 L-46e ch3 Η c(ch3) 2c.h2so2ch3 ch3 L-46f ch3 Η C(CH3) 2ch2so2ch3 ch3 L-46g ch3 Η C(CH3) 2ch2so2ch3 ch3 L-46j ch3 Η C(CH3) 2ch2so2ch3 ch3 L-46k ch3
318 314918 200407073 Η C(CH3) 2ch2so2ch3 ch3 L-46r ch3 Η c(ch3)2ch2so2ch3 ch3 L - 47a ch3 Η C(CH3) 2ch2so2ch3 ch3 L-47e ch3 Η C(CH3)2CH2SEt ch3 cf3 Ph~4_F Η C(CH3)2CH2SEt ch3 cf3 Ph-4-Cl Η C(CH3)2CH2SEt ch3 cf3 Ph-4-Br Η C(CH3)2CH2SEt ch3 cf3 Ph+I Η C(CH3)2CH2SEt ch3 cf3 Ph-4-CF3 Η C(CH3) 2CH2SEt ch3 cf3 Ph-4-0CHF2 Η C(CH3)2CH2SEt ch3 cf3 Ph-4-0CF3 Η C(CH3)2CH2SEt ch3 cf3 Ph-4-0CF2Br Η C(CH3)2CH2SEt ch3 cf3 Ph-4-0CF2CHF2' Η C(CH3)2CH2SEt ch3 cf3 Ph-4-0CF2CHFCF Η C(CH3) 2CH2SEt ch3 cf3 Ph-4-CN Η C(CH3)2CH2SEt ch3 cf3 Ph-3, 4-F2 Η C(CH3)2CH2SEt ch3 cf3 Ph-3-F-4_C1 Η C(CH3)2CH2SEt ch3 cf3 Ph-3,4-Cl2 Η C(CH3)2CH2SEt ch3 cf3 L - 46d Η C(CH3) 2CH2SEt ch3 cf3 L - 46e Η C(CH3)2CH2SEt ch3 cf3 L-46g Η C(CH3)2CH2SEt ch3 cf3 L-46j Η C(CH3) 2CH2SEt ch3 cf3 L - 46k Η C(CH3)2CH2SEt ch3 cf3 L - 46r Η C(CH3) 2CH2SEt ch3 Ph_4-F ch3 Η C(CH3) 2CH2SEt ch3 Ph+Cl ch3 Η C(CH3)2CH2SEt ch3 Ph-4-Br ch3 Η C(CH3) 2CH2SEt ch3 Ph+I ch3 Η C(CH3) 2CH2SEt ch3 Ph+CF3 ch3 Η C(CH3) 2CH2SEt ch3 Ph-4-0CHF2 ch3 Η C(CH3) 2CH2SEt ch3 Ph-4-OCFa ch3 Η C(CH3)2CH2SEt ch3 Ph-4-0CF2Br ch3 Η C(CH3) 2CH2SEt ch3 Ph-4-0CF2CHF2 ch3 Η C(CH3)2CH2SEt ch3 Ph-4-0CF2CHFCF3 ch3 Η C(CH3)2CH2SEt ch3 Ph-3, 4-Cl 2 ch3 Η C(CH3)2CH2S(0)Et ch3 cf3 Ph_4-F Η C(CH3)2CH2S(0)Et ch3 cf3 Ph-4-Cl Η C(CH3)2CH2S(0)Et ch3 cf3 Ph-4-Br 200407073 Η C(CH3)2CH2S(0)Et ch3 cf3 Ph-4-1 Η C(CH3)2CH2S(0)Et ch3 cf3 Ph-4-CF3 Η C(CH3)2CH2S(0)Et ch3 cf3 Ph-4-0CHF2 Η C(CH3) 2CH2S(0)Et ch3 cf3 Ph-4-0CF3 Η C(CH3) 2CH2S(0)Et ch3 cf3 Ph-4-0CF2Br Η C(CH3) 2CH2S(0)Et ch3 cf3 Ph-4-0CF2CHF2 Η C(CH3) 2CH2S(0)Et ch3 cf3 Ph-4~0CF2CHFCF Η C(CH3) 2CH2S(0)Et ch3 cf3 Ph-4-CN Η C(CH3)2CH2S(0)Et ch3 cf3 Ph-3, 4-F2 Η C(CH3) 2CH2S(0)Et ch3 cf3 Ph-3-F-4-C1 Η C(CH3) 2CH2S(0)Et ch3 cf3 Ph-3, 4-Cl2 Η C(CH3) 2CH2S(0)Et ch3 Ph-4-F ch3 ' Η C(CH3) 2CH2S(0)Et ch3 Ph+Cl ch3 Η C(CH3)2CH2S(0)Et ch3 Ph-4-Br ch3 Η C(CH3) 2CH2S(0)Et ch3 Ph-4-I ch3 Η C(CH3)2CH2S(0)Et ch3 Ph+CF3 ch3 Η C(CH3)2CH2S(0)Et ch3 Ph-4-0CHF2 ch3 Η C(CH3) 2CH2S(0)Et ch3 Ph-4-0CF3 ch3 . Η C(CH3) 2CH2S(0)Et ch3 Ph~4^0CF2Br ch3 Η C(CH3) 2CH2S(0)Et ch3 Ph-4-0CF2CHF2 ch3 Η C(CH3) 2CH2S(0)Et ch3 Ph-4-0CF2CHFCF3 ；ch3 Η C(CH3) 2CH2S(0)Et ch3 Ph_3,4_Cl2 ch3 Η C(CH3) 2CH2S02Et ch3 cf3 Ph~4-F Η C(CH3) 2CH2S02Et ch3 cf3 Ph-4-C1 Η C(CH3) 2CH2S02Et ch3 cf3 Ph-4-Br Η C(CH3) 2CH2S02Et ch3 cf3 Ph-4-I Η C(CH3) 2CH2S02Et ch3 cf3 Ph-4-CF3 Η C(CH3) 2CH2S02Et ch3 cf3 Ph-4-0CHF2 Η C(CH3)2CH2S02Et ch3 cf3 Ph_4_0CF 3 Η C(CH3) 2CH2S02Et ch3 cf3 Ph-4-0CF2Br Η C(CH3) 2CH2S02Et ch3 cf3 Ph-4-0CF2CHF2 Η C(CH3) 2CH2S02Et ch3 cf3 Ph-4-0CF2CHFCF: Η C(CH3) 2CH2S02Et ch3 cf3 Ph+CN Η C(CH3) 2CH2S02Et ch3 cf3 Ph - 3,4-F2 Η C(CH3) 2CH2S02Et ch3 cf3 Ph-3~F-4-Cl Η C(CH3) 2CH2S02Et ch3 cf3 Ph-3. 4-Cl2 Η C(CH3) 2ch2so2ei ch3 cf3 L - 46d
320 314918 200407073 H C(CH3) 2CH2S02Et H C(CH3) 2CH2S02Et H C(CH3)2CH2S02Et H C(CH3) 2CH2S02Et H C(CH3) 2CH2S02Et H C(C.H3)2CH2S02Et H C(CH3) 2CH2S02Et H C(CH3) 2CH2S02Et H C(CH3) 2CH2S02Et H C(CH3) 2CH2S02Et H C(CH3) 2CH2S02Et H C(CH3) 2CH2S02Et H C(CH3) 2CH2S02Et H C(CH3) 2CH2S02Et H C(CH3)2CH2S02Et H C(CH3)2CH2S02Et H C(CH3)2CH2SPr - n H C(CH3) 2CH2SPr-n H C(CH3) 2CH2SPr-n H C(CH3)2CH2SPr - n H C(CH3)2CH2SPr - n H C(CH3) 2CH2SPr-n H C(CH3) 2CH2SPr-n H C(CH3)2CH2SPr&gt;n H C(CH3)2CH2SPr - n H C(CH3) 2CH2SPr-n H C(CH3) 2CH2SPr-n H C(CH3) 2CH2SPr-n H C(CH3)2CH2S(0)Pr-n H C(CH3)2CH2S(0)Pr-n H C(CH3) 2CH2S02Pr-n H C(CH3) 2CH2S02Pr-n H C(CH3) 2CH2S02Pr-n H C(CH3)2CH2S02Pr-n H C(CH3) 2CH2S02Pr-n H C(CH3) 2CH2S02Pr-n H C(CH3) 2CH2S02Pr-n ch3 cf3 L - 46e ch3 cf3 L-46g ch3 cf3 L-46j ch3 cf3 L-46k ch3 cf3 L - 46r ch3 Ph-4-F ch3 ch3 Ph-4-Cl ch3 ch3 Ph-4-Br ch3 ch3 Ph-4-I ch3 ch3 Ph-4-CF3 ch3 ch3 Ph-4-0CHF2 ch3 ch3 Ph-4_0CF 3 ch3 ch3 Ph-4-0CF2Br ch3 ch3 Ph-4-0CF2CHF2 ch3 ch3 Ph-4_0CF2CHFCF3 丨ch3 ch3 Ph-3, 4&gt;C12 ch3 ch3 cf3 Ph-4-F ch3 cf3 Ph-4-Cl ch3 cf3 Ph-4-Br ch3 cf3 Ph-4-CF3 ch3 cf3 Ph-4-0CHF ch3 cf3 Ph-4-0CF3 ch3 Ph-4-F ch3 ch3 Ph-4-C1 ch3 ch3 Ph-4-Br ch3 ch3 Ph~4~CF 3 ch3 ch3 Ph-4-0CHF2 ch3 ch3 Ph-4_0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph+0CF3 ch3 ch3 cf3 Ph-4-F ch3 cf3 Ph+Cl ch3 cf3 Ph-4-Br ch3 cf3 Ph-4-CF3 ch3 cf3 Ph-4-0CHF ch3 cf3 Ph~4~0CF 3 ch3 Ph_4~F ch3
321 314918 200407073 Η C(CH3)2CH2S02Pr - η ch3 Ph-4-Cl ch3 Η C(CH3) 2CH2S02Pr-n ch3 Ph-4-Br ch3 Η C(CH3)2CH2S02Pr - η ch3 Ph+CF3 ch3 Η C(CH3)2CH2S02Pr - η ch3 Ph-4-0CHF2 ch3 Η C(CH3) 2CH2S02Pr-η ch3 Ph-4-0CF3 ch3 Η C(CH3) 2CH2SPr-i ch3 cf3 Ph-4-F Η C(CH3)2CH2SPr - i ch3 cf3 Ph-4-Cl Η C(CH3) 2CH2SPr-i ch3 cf3 Ph-4-Br Η C(CH3) 2CH2SPr-i ch3 cf3 Ph-4-CF3 Η C(CH3)2CH2SPr - i ch3 cf3 Ph-4-0CHF Η C(CH3)2CH2SPr-i ch3 cf3 Ph-4-0CF3 Η C(CH3) 2CH2SPr-i ch3 Ph-4*~F ch3 Η C(CH3) 2CH2SPr-i ch3 Ph+Cl ch3 Η c(ch3) 2CH2SPM ch3 Ph-4-Br ch3 Η C(CH3)2CH2SPr - i ch3 Ph-4-CF3 ch3 Η C(CH3) 2CH2SPr-i ch3 Ph-4~0CHF2 ch3 Η C(CH3}2CH2SPr_i ch3 Ph+0CF3 ch3 Η C(CH3)2CH2S(0)Pr - i ch3 cf3 Ph-4-Cl Η C(CH3) 2CH2S(0)Pr-i ch3 Ph-4~0CF3 ch3 Η C(CH3)2CH2S02Pr-i ch3 cf3 Ph-4-Cl Η C(CH3) 2CH2S02Pr-i ch3 Ph-4-0CF3 ch3 Η C(CH3) 2CH2SBu-1 ch3 cf3 Ph-4-Cl Η C(CH3) 2CH2S(0) Bu-t ch3 Ph-4-0CF3 ch3 Η C(CH3) 2CH2SPh ch3 cf3 Ph-4-Cl Η C(CH3) 2CH2S(0)Ph ch3 Ph-4-0CF3 ch3 Η C(CH3) 2CH2S02Ph ch3 cf3 Ph-4-Cl Η C(CH3)2CH2SCH2(Ph-4-Cl) CH3 Ph-4-0CF3 ch3 Η C(CH3) 2CH2S(L-45a) ch3 cf3 Ph-4-Cl Η C(CH3)2CH2S(0) (L-45a) ch3 Ph-4-0CF3 ch3 Η C(CH3)2CH2S02(L_45a) ch3 cf3 Ph-4-Cl Η CH2CH2CH2SCH3 ch3 Ph-4-OCFs ch3 Η CH (CH3)CH2CH2SCH3 ch3 cf3 Ph-4-F Η ch(ch3)ch2ch2sch3 ch3 cf3 Ph-4-Cl Η CH (CH3)CH2CH2SCH3 ch3 cf3 Ph-4-Br Η CH (CH3)CH2CH2SCH3 ch3 cf3 Ph+CF3 Η CH (CH3)CH2CH2SCH3 ch3 cf3 Ph-4-0CHF, Η CH (CH3)CH2CH2SCH3 ch3 cf3 Ph+0CF3
322 314918 200407073 Η CH (CH3)CH2CH2SCH3 ch3 Ph-4-F ch3 Η CH (CH3)CH2CH2SCH3 ch3 Ph-4-Cl ch3 Η CH (CH3)CH2CH2SCH3 ch3 Ph-4-Br ch3 Η CH (CH3)CH2CH2SCH3 ch3 Ph-4-CF3 ch3 Η CH (CH3)CH2CH2SCH3 ch3 Pii - 4_0CHF2 ch3 Η CH (CH3)CH2CH2SCH3 ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2CH2S(0) ch3 ch3 cf3 Ph-4-F Η CH (CH3)CH2CH2S(0) ch3 ch3 cf3 Ph-4-Cl Η CH (CH3)CH2CH2S(0) ch3 ch3 cf3 Ph-4-Br Η CH (CH3)CH2CH2S(0) ch3 ch3 cf3 Ph+CF3 Η CH (CH3)CH2CH2S(0) ch3 ch3 cf3 Ph-4-OCHF Η CH (CH3)CH2CH2S(0) ch3 ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2CH2S(0) ch3 ch3 Ph-4-F ch3 Η CH (CH3)CH2CH2S(0) ch3 ch3 Ph-4-Cl ch3 Η CH (CH3)CH2CH2S(0) ch3 ch3 Ph~4_Br ch3 Η CH (CH3)CH2CH2S(0) ch3 ch3 Ph-4-CF3 ch3 Η CH (CH3)CH2CH2S(0) ch3 ch3 Ph-4-0CHF2 ch3 Η CH (CH3)CH2CH2S(0) ch3 ch3 PM - 0CF3 ch3 Η CH (CH3)CH2CH2S02CH3 ch3 cf3 Ph-4-F Η CH (CH3) CH2CH2S02CH3 ch3 cf3 Ph-4-C1 Η CH (CH3)CH2CH2S02CH3 ch3 cf3 Ph-4-Br Η CH (CH3)CH2CH2S02CH3 ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2CH2S02CH3 ch3 cf3 Ph-4-OCHF Η CH (CH3)CH2CH2S02CH3 ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2CH2S02CH3 ch3 Ph-4-F ch3 Η CH (CH3)CH2CH2S02CH3 ch3 Ph-4-Cl ch3 Η CH (CH3)CH2CH2S02CH3 ch3 Ph-4-Br ch3 Η CH (CH3)CH2CH2S02CH3 ch3 Ph-4_CF3 ch3 Η CH (CH3)CH2CH2S02CH3 ch3 Ph-4-0CHF2 ch3 Η CH (CH3)CH2CH2S02CH3 ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2CH2SEt ch3 cf3 Ph~4~F Η CH (CH3)CH2CH2SEt ch3 cf3 Ph+Cl Η CH (CH3)CH2CH2SEt ch3 cf3 Ph+Br Η CH (CH3)CH2CH2SEt ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2CH2SEt ch3 cf3 Ph-4-OCHF Η CH (CH3)CH2CH2SEt ch3 CF3 Ph-4-0CF3 Η CH (CH3)CH2CH2SEt ch3 Ph~4_F ch3
323 314918 200407073 Η CH (CH3)CH2CH2SEt ch3 Ph-4-Cl ch3 Η CH (CH3)CH2CH2SEt ch3 Ph-4-Br ch3 Η CH (CH3)CH2CH2SEt ch3 Ph-4-CF3 ch3 Η CH (CH3)CH2CH2SEt ch3 Ph-4-0CHF2 ch3 Η CH (CH3)CH2CH2SEt ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2CH2S(0)Et ch3 CF3 Ph-4-Cl Η CH (CH3)CH2CH2S(0)Et ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH2CH2S02Et ch3 cf3 Ph-4-Cl Η CH (CH3)CH2CH2S02Et ch3 Ph-4-0CF3 ch3 Η CH (Et) CH2CH2SCH3 ch3 cf3 Ph-4-Cl Η CH (CH20H) ch2ch2sch3 ch3 Ph-4-0CF3 ch3 Η C(CH3) 2ch2ch2sch3 ch3 cf3 Ph-4-C1 Η C(CH3) 2CH2CH2SEt ch3 Ph-4-0CF3 ch3 Η ch(ch3) (ch2) 3sch3 ch3 cf3 Ph-4-F Η CH(CH3) (CH2) 3SCH3 ch3 cf3 Ph-4-Cl Η CH(CH3) (CH2) 3SCH3 ch3 cf3 Ph~4_Br Η CH(CH3) (CH2) 3SCH3 ch3 cf3 Ph-4-CF3 Η CH(CH3) (CH2) 3SCH3 ch3 cf3 Ph-4-0CHF Η CH(CH3) (CH2) 3SCH3 ch3 cf3 Ph-4-0CF3 Η CH(CH3) (CH2) 3SCH3 ch3 Ph-4-F ch3 Η CH(CH3) (CH2) 3SCH3 ch3 Ph-4-Cl ch3 Η CH(CH3) (CH2) 3SCH3 ch3 Ph-4_Br ch3 Η CH(CH3) (CH,) 3SCH3 ch3 Ph-4-CF3 ch3 Η CH(CH3) (CH2) 3SCH3 ch3 Ph-4-0CHF2 ch3 Η CH(CH3) (CH2) 3SCH3 ch3 Ph-4-0CF3 ch3 Η CH(CH3) (CH2) 3S(0)CH3 ch3 cf3 Ph-4-Cl Η CH(CH3) (CH2) 3S(0)CH3 ch3 Ph-4-0CF3 ch3 Η ch(ch3) (ch2) 3so2ch3 ch3 cf3 Ph-4-F Η ch(ch3) (ch2) 3so2ch3 ch3 cf3 Ph+Cl Η CH(CH3) (CH2) 3so2ch3 ch3 cf3 Ph-4-Br Η CH(CH3) (ch2) 3so2ch3 ch3 cf3 Ph-4-CF 3 Η ch(ch3) (ch2) 3so2ch3 ch3 cf3 Ph-4-0CHF Η CH(CH3) (CH2) 3so2ch3 ch3 cf3 Ph~4~0CF 3 Η ch(ch3) (ch2) 3so2ch3 ch3 Ph~4_F ch3 Η CH(CH3) (ch2) 3so2ch3 ch3 Ph-4-C1 ch3 Η CH(CH3) (CH2) 3so2ch3 ch3 Ph-4-Br ch3 Η CH(CH3) (CH2) 3SO2CH3 ch3 Ph-4-CF3 ch3 324 314918 200407073 Η CH(CH3) (ch2) 3so2ch3 ch3 Ph-4-0CHF2 ch3 Η CH(CH3) (CH2) 3so2ch3 ch3 Ph-4-0CF3 ch3 Η CH(CH3) (CH2) 3SEt ch3 cf3 Ph-4-F Η CH(CH3) (CH2) 3SEt ch3 cf3 Ph-4-Cl Η CH(CH3) (CH2) 3SEt ch3 cf3 Ph-4-Br Η CH(CH3) (CH2) 3SEt ch3 cf3 Ph-4-CF3 Η CH(CH3) (CH2) 3SEt ch3 cf3 Ph-4-0CHF Η CH(CH3) (CH2) 3SEt ch3 cf3 Ph_4-OCF3 Η CH(CH3) (CH2) 3SEt ch3 Ph-4_F ch3 Η CH(CH3) (CH2) 3SEt ch3 Ph-4-Cl ch3 Η CH(CH3) (CH2) 3SEt ch3 Ph_4-Br ch3 Η CH(CH3) (CH2) 3SEt ch3 Ph-4-CF3 ch3 Η CH(CH3) (CH2) 3SEt ch3 Ph-4-0CHF2 ch3 Η CH(CH3) (CH2) 3SEt ch3 Ph-4-0CF3 ch3 Η ch(ch3) (ch2)3s_ ch3 cf3 Ph-4-Cl Η CH(CH3) (CH2) 3S(0)Et ch3 Ph-4-0CF3 ch3 Η CH(CH3) (CH2) 3S02Et ch3 cf3 Ph-4-Cl Η CH(CH3) (CH2) 3S02Et ch3 Ph-4-0CF3 ch3 . Η C(CH3) 2 (CH2) 3SCH3 ch3 cf3 Ph-4-F Η C(CH3) 2 (CH2) 3SCH3 ch3 cf3 Ph-4-C1 Η C(CH3) 2 (CH2) 3SCH3 ch3 cf3 Ph-4-Br Η C(CH3) 2 (CH2) 3SCH3 ch3 cf3 Ph-4-CF3 Η C(CH3) 2 O2) 3SCH3 ch3 cf3 Ph-4-OCHF； Η C(CH3) 2 (CH2) 3SCH3 ch3 cf3 Ph-4-0CF3 Η C(CH3) 2 (CH2) 3SCH3 ch3 Ph~4-F ch3 Η C(CH3) 2 (CH2) 3SCH3 ch3 Ph-4-C1 ch3 Η C(CH3) 2 (CH2) 3SCH3 ch3 Ph-4-Br ch3 Η C(CH3) 2 (CH2) 3SCH3 ch3 Ph-4-CF3 ch3 Η C(CH3) 2 (CH2) 3SCH3 ch3 \ Ph_[0CHF2 ch3 Η C(CH3) 2 (CH2) 3SCH3 ch3 Ph-4-0CF3 ch3 Η C(CH3) 2 (CH2) 3SEt ch3 cf3 Ph-4_F Η C(CH3) 2 (CH2) 3SEt ch3 cf3 Ph-4-Cl Η C(CH3) 2 (CH2) 3SEt ch3 cf3 Ph~4~Br Η C(CH3) 2 (CH2) 3SEt ch3 cf3 Ph-4_CF 3 Η C(CH3) 2 (CH2) 3SEt ch3 cf3 Ph-4-0CHF: Η C(CH3) 2 (CH2) 3SEt ch3 cf3 Ph-4-OCF3 Η C(CH3) 2 (CH2) 3SEt ch3 Ph~4~F ch3
325 314918 200407073 H C(CH3) 2 (CH2) 3SEt H C(CH3) 2 (CH2) 3SEt H C(CH3) 2 (CH〇) 3SEt H C(CH3) 2 (CH2) 3SEt H C(CH3) 2 (CH2) 3SEt H C(CH3) 2CH2CH2CH(CH3)SCH H CH(CH3) (CH2)4SCH3 H CH(CH3) (CH2) 4so2ch3 H CH(CH3) (CH2) 4SEt H CH(CH3) (CH2) 4S(0)Et H CH(CH3) (CH2) 4S02Et Η T-6 Η T-7 Η T-8 Η T-9 Η T-ll Η T -12 Η T-13 Η T -14 Η T-15 Η M - 8a Η M-9a Η M - 9b Η M - 9c Η M-19a H CH2NHC (0) 0CH3 H CH2NHC (0) OEt H CH2NHC (0) OPr-i H CH2NHC (0) OPr-i H CH2NHC (0) OPr-i H CH2NHC (0) OPr-i H CH2NHC(0)0Pr - i H CH2NHC (0) OPr-i H CH2NHC (0) OPr-i H CH2NHC (0) OPr-i H CH2NHC (0) OPr-i H CHoNHC (0) OPr-i ch3 Ph-4-Cl ch3 ch3 Ph_4~Br ch3 ch3 Ph-4-CF3 ch3 ch3 Ph-4-0CHF2 ch3 ch3 Ph-4-0CF3 ch3 ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-C! ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph+0CF3 ch3 ch3 cf3 Ph+Cl ch3 Ph-4_0CF 3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 PlHhOCF3 ch3 . ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph+Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 cf3 Ph~4~F ch3 cf3 Ph-4-Cl ch3 cf3 Ph-4-Br ch3 cf3 Ph+CF3 ch3 cf3 Ph-4-OCF ch3 Ph-4-F ch3 ch3 Ph+Cl ch3 ch3 Ph-4-Br ch3 ch3 Ph-4-CF3 ch3 ch3 Ph-4-0CF3 ch3 326 314918 200407073 H CH2CH2NHC (0) ch3 H CH2CH2NHC (0)N(CH3) 2 H CH2CH2NHC (0) Ph H CH2CH2N(CH3)OCH3 H CH (CH3)CH2NHC (0) CH3 H CH (CH3)CH2NHC (0) CH3 H CH (CH3)CH2NHC (0) CH3 H CH (CH3)CH2NHC (0) CH3 H CH (CH3)CH2NHC (0) CH3 H CH (CH3)CH2NHC (0) CH3 H CH (CH3)CH2NHC (0) CH3 H CH (CH3)CH2NHC (0) CH3 H CH (CH3)CH2NHC (0) CH3 H CH (CH3)CH2NHC (0) CH3 H CH (CH3)CH2NHC (0)Et H CH (CH3)CH2NHC (0) 0CH3 H CH (CH3)CH2NHC (0)N(CH3) 2 H CH(CH3)CH2NHC ⑸ NHEt H CH (CH3)CH2NHS02CH3 H CH (CH3)CH2NHS02Et H CH (CH3)CH2NHS02Ph H CH (CH3)CH2NHS02N(CH3) 2 H CH(CH3)CH2NHP(S) (0CH3) 2 H CH(CH3)CH2NHP(S) (OEt) 2 H CH (CH3)CH2N(CH3) 2 H CH (CH3)CH2N(CH3)S02CH3 H CH(CH3)CH2N(CH3)S02CH3 h ch(ch3)ch2n(ch3)so2ch3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH(CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-C1 ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 cf3 Ph-4-F ch3 cf3 Ph-4-C1 ch3 cf3 Ph-4-Br ch3 cf3 Ph-4-CF3 ch3 cf3 Ph-4_0CF3 ch3 Ph-4-F ch3 ch3 Ph-4-Cl ch3 ch3 Ph-4-Br ch3 ch3 Ph-4-CF3 ch3 ch3 Ph-4-0CF3 ch3 ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-OCF3 ch3 ch3 cf3 P1H.- Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 F cf3 Ph-4-S02CH Cl cf3 Ph-4-F Cl Ph-4-0CF3 ch3 Br cf3 Ph-4-C1 ch3 ch3 Ph-4-F ch3 Et Ph+S02CH ch3 n-Pr L - 46d ch3 i-Pr Ph-4-F ch3 chf2 Ph-4-S02CH ch3 cf3 Cl ch3 cf3 ch3 ch3 cf3 〇ch3 327 314918 200407073 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH(CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH(CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3) S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 h ch(ch3)ch2n(ch3)so2ch3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH(C.H3)CH2N(CH3)S02CH3 ch3 cf3 sch3 ch3 cf3 n(ch3)2 ch3 cf3 Ph-4-F ch3 cf3 Ph-4-Cl ch3 cf3 Ph_4~Br ch3 cf3 Ph-4-I ch3 cf3 Ph~4~CF 3 ch3 cf3 Ph_4-0CHF2 ch3 cf3 Ph-4-0CF3 ch3 cf3 Ph-4-0CF2Br ch3 cf3 Ph-4-0CF2CHF2 ch3 cf3 Ph-4-0CF2CHFCF3 ch3 cf3 Ph-4-0CF2CHF0CF3 ch3 cf3 Ph-4-0CF2CHF0CF2CF2CF ch3 cf3 Ph+SCH3 ch3 cf3 Ph-4-S (0) CH3 ch3 cf3 Ph+S02CH3 ch3 cf3 Ph-4. - SCF 3 ch3 cf3 Ph-4-CN ch3 cf3 Ph-3, 4-F2 ch3 cf3 Ph-3-F-4-Cl ch3 cf3 Ph-3-F-4-CF3 ch3 cf3 Ph-3, 4-Cl2 ch3 cf3 Ph-3-Cl-4-0CF3 ch3 cf3 L-14b ch3 cf3 L-14c ch3 cf3 L - 14d ch3 cf3 L-14f ch3 cf3 L-14h ch3 cf3 L-24b ch3 CFa L-24c ch3 cf3 卜24e ch3 cf3 L-36c ch3 CFa L-36d ch3 cf3 L - 45d ch3 cf3 L-45e
328 314918 200407073 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH(CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH(CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH(CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH(CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH(CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH,N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH(CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH(CH3)CH2N(CH3)S02CH3 H CH (CH3)CH2N(CH3)S02CH3 H CH(CH3)CH2N(CH3)S02CH3 h ch(ch3)ch2n(ch3)so2ch3 ch3 cf3 L-45g ch3 cf3 L-45m ch3 cf3 L-46d ch3 cf3 L-46e ch3 cf3 L-46g ch3 cf3 L-46j ch3 cf3 L-46k ch3 cf3 L - 46r ch3 cf2ci L-46d ch3 cf2cf3 Ph-4-F ch3 Ph-4-F ch3 ch3 Ph-4-Cl ch3 ch3 Ph-4-Br ch3 ch3 Ph-4-I ch3 ch3 Ph-4-CF3 ch3 ch3 Ph-4_0CHF2 ch3 ch3 Ph-4-0CF3 ch3 ch3 Ph~4~0CF2Br ch3 . ch3 Ph-4-0CF2CHF2 ch3 ch3 Ph-4-0CF2CHFCl ch3 ch3 Ph-4-0CF2CHFCF3 CH3 ch3 Ph-4_0CF2CHF0CF: 3 CH ch3 Ph-4-0CF2CHF0CF〇CF2CF3 CH ch3 Ph-3, 4-F2 ch3 ch3 Ph-3-F-4-C1 ch3 ch3 Ph-3,4-Cl2 ch3 ch3 L-lc ch3 ch3 L-ld ch3 ch3 L - le ch3 ch3 L-li ch3 ch3 L - 2b ch3 ch3 L-3d ch3 ch3 L - 3e ch3 ch3 L-3f ch3 ch3 L - 31 ch3 ch3 L-3o ch3 ch3 L-4c ch3
329 314918 200407073 Η C(CH3) 2CH2NHC (0) ch3 ch3 cf3 Ph-4-C1 Η C(CH3) 2CH2NHC (0)Et ch3 Ph+OCF3 ch3 Η C(CH3) 2CH2NHC (O)Pr-c ch3 cf3 Ph-4-C1 Η C(CH3) 2CH2NHC (O)Bu-t ch3 Ph-4-0CF3 ch3 Η C(CH3) 2CH2NHC (0) cf3 ch3 cf3 Ph-4-Cl Η C(CH3) 2CH2NHC (0) Ph ch3 Ph-4-0CF3 ch3 Η C(CH3) 2CH2NHC (0) och3 ch3 cf3 Ph~4~F Η C(CH3) 2CH2NHC (0) och3 ch3 cf3 Ph-4-Cl Η C(CH3) 2CH2NHC (0) och3 ch3 cf3 Ph-4-Br Η C(CH3) 2ch2nhc (0)0CH3 ch3 cf3 Ph+CF3 Η C(CH3) 2ch2nhc (0)0CH3 ch3 cf3 Ph-4-OCHF2 Η C(CH3) 2CH2NHC (0) och3 ch3 cf3 Ph-4-0CF3 Η C(CH3) 2CH2NHC (0) och3 ch3 cf3 Ph-4-CN Η C(CH3) 2CH2NHC (0) och3 ch3 cf3 Ph-3, 4-Cl2 Η C(CH3) 2CH2NHC (0) och3 ch3 Ph+F ch3 Η C(CH3) 2CH2NHC (0) och3 ch3 Ph-4-C1 ch3 Η C(CH3) 2CH2NHC (0) och3 ch3 Ph**4 - Br ch3 Η C(CH3) 2CH2NHC (0) och3 ch3 Ph-4-CF3 ch3. Η C(CH3) 2CH2NHC (0) och3 ch3 Ph-4-0CHF2 ch3 Η C(CH3) 2CH2NHC (0) och3 ch3 Ph-4-OCF3 ch3 Η C(CH3) 2CH2NHC (0) och3 ch3 Ph-4-CN ch3 Η C(CH3) 2CH2NHC (0) och3 ch3 Ph-3,4-Cl2 ch3 Η C(CH3) 2CH2NHC (0) OEt ch3 cf3 Ph-4-Cl Η C(CH3) 2CH2NHC (0) OPr-n ch3 Ph-4-OCF3 ch3 Η CH2CH2CH2NHC (0) och3 ch3 cf3 Ph-4-Cl Η CH2CH2CH2NHC (0) OBu-t ch3 Ph-4-0CF3 ch3 Η CH2CH2CH2N(CH3) 2 ch3 cf3 Ph-4-Cl Η CH2CH2CH2N(CH3)OCH3 ch3 Ph-4-0CF3 ch3 Η M-22a ch3 Fa Ph-4-Cl Η CH2Si (CH3) 3 ch3 Ph+0CF3 ch3 Η C(CH3) 2CHO ch3 cf3 Ph-4-Cl Η ch(ch3)uo)ch3 ch3 Ph-4-0CF3 ch3 Η CH (CHO) CH2S02CH3 ch3 cf3 Ph+Cl Η C(CH3) (CH0)CH2S02CH3 ch3 Ph-4-0CF3 ch3 Η C(CH3) (CH0)CH2S02Et ch3 cf3 Ph-4-Cl Η CH2CH=N0CH3 ch3 Ph-4-0CF3 ch3 Η CH2C(Ph) -NOCH3 ch3 cf3 Ph-4-Cl
330 314918 200407073 F cf3 Cl cf3 Cl Ph-4-0CF Br cf3 ch3 ch3 ch3 Et ch3 n-Pr ch3 i-Pr ch3 chf2 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 CF, H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH(CH3)CH=NOCH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH(CH3)CH=NOCH3 H CH (CH3) CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3) CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH-N0CH3 H CH(CH3)CH:NOCH3 H CH (CH3)CH=N0CH3 H CH (CH3) WOCH3
Ph-4-F Ph-4-C1 CH3
Ph_4-S02CH3
Ph-4-S02CH3 L - 46d
Ph-4-F
Ph-4-S02CH3 L-46d
Cl CH3 0CH3 SCH3 N(CH3) 2
Ph~4~F
Ph-4-Cl
Ph~4~Br
Ph-4-I .
Ph+CF3
Ph-4-0CHF2
Ph-4-0CF3
Ph-4-0CF2Br
Ph-4-0CF2CHF2
Ph-4-0CF2CHFCl
Ph-4-0CF2CHFCF3
Ph-4-0CF2CHF0CF3
Ph-4-0CF2CHF0CF2CF2CF3
Ph-4_0S02CH3
Ph-4-SCH3
Ph+S(0)CH3
Ph-4-S02CH3
Ph*~4~SEt
Ph-4-S02Et
Ph-4-SPr-i
Ph-4-S02Pr-i
Ph-4-SCHF2
Ph-4-S02CHF2 331 314918 200407073 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)M0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH(CH3)CH=NOCH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH(CH3)CH=NOCH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3
ch3 cf3 Ph-4-SCFs ch3 cf3 Ph-4-S02CF3 ch3 cf3 Ph-4-SCF2Cl ch3 cf3 Ph-4-S02CF2Cl ch3 cf3 Ph-4-SCF2Br ch3 cf3 Ph-4-S02CF2Br ch3 cf3 Ph-4-N02 ch3 cf3 Ph-4-CN ch3 cf3 Ph+C(0)NH2 ch3 cf3 Ph-4-C (S) NH2 ch3 cf3 Ph-3, 4-F2 ch3 cf3 Ph-3-F-4-Cl ch3 cf3 Ph~3~F~4~CF 3 ch3 cf3 Ph-3, 4-Cl2 ch3 cf3 Ph-3-Cl-4-OCF2 ch3 cf3 L-14b ch3 cf3 L-14c ch3 cf3 L-14d ch3 cf3 L-14i ch3 cf3 L- 14h ch3 cf3 L-24b ch3 cf3 L-24c ch3 cf3 L - 24e ch3 cf3 L-36c ch3 cf3 L - 36d ch3 cf3 L-45c ch3 cf3 L-45d ch3 cf3 L-45e ch3 cf3 L-45f ch3 cf3 L-45g ch3 cf3 L~45m ch3 cf3 L-46c ch3 cf3 L - 46d ch3 c.f3 L-46e ch3 cf3 L-46f ch3 cf3 L-46g ch3 cf3 L-46j 勹Λ 〇 JJZ
314918 200407073 Η CH (CH3)CH=N0CH3 ch3 cf3 L-46k Η CH (CH3)CH=N0CH3 ch3 cf3 L-46m Η CH (CH3)CH=N0CH3 ch3 cf3 L - 46n Η ch(ch3)c_ch3 ch3 cf3 L - 46o Η CH (CH3)CH=N0CH3 ch3 cf3 L-46p Η CH (CH3)CH=N0CH3 ch3 cf3 L - 46r Η CH (CH3)CH=N0CH3 ch3 cf3 L-47a Η CH (CH3)CH=N0CH3 ch3 cf3 L-47e Η ch(ch3)ch=_3 ch3 cf3 L-48b Η CH (CH3)CH=N0CH3 ch3 cf3 L-50b Η CH (CH3)CH=N0CH3 ch3 cf3 L - 50c Η CH (CH3)CH=N0CH3 ch3 cf3 L - 50e Η CH (CH3)CH=N0CH3 ch3 cf3 L-51b Η CH (CH3)CH=N0CH3 ch3 cf3 L-51c Η CH (CH3)CH=N0CH3 ch3 cf2ci Ph-4-F Η CH (CH3)CH=N0CH3 ch3 cf2cf3 Ph-4-S〇2CH3 Η CH (CH3)CH=N0CH3 ch3 Ph-4-F ch3 Η CH (CH3)CH=N0CH3 ch3 Ph-4-Cl ch3 Η CH (CH3)CH=N0CH3 ch3 Ph-4-Br ch3 Η CH (CH3)CH=N0CH3 ch3 Ph-4-I ch3 Η CH (CH3)CH=N0CH3 ch3 Ph-4-CF3 ch3 Η ch(ch3)ch=_3 ch3 Ph-4-0CHF2 ch3 Η CH (CH3)CH=N0CH3 ch3 Ph-4_0CF3 ch3 Η CH (CH3)CH=N0CH3 ch3 Ph-4-0CF2Br ch3 Η CH (CH3)CH=N0CH3 ch3 Ph-4-0CF2CHF2 ch3 Η CH (CH3)CH=N0CH3 ch3 Ph-4-0CF2CHFCl ch3 Η CH (CH3)CH=N0CH3 ch3 Ph-4-0CF2CHFCF3 ch3 Η CH (CH3)CH=N0CH3 ch3 Ph-4-0CF2CHF0CF； 3 ch3 Η CH (CH3)CH=N0CH3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 ch3 Η CH (CH3)CH=N0CH3 ch3 Ph-4-SCFa ch3 Η CH (CH3)CH=N0CH3 ch3 Ph-3,4_F2 ch3 Η CH (CH3)CH=N0CH3 ch3 Ph_3-F-4-Cl ch3 Η CH (CH3)CH=N0CH3 ch3 Ph-3, 4-Cl2 ch3 Η ch(ch3)cmoch3 ch3 L- lc ch3 Η CH (CH3)CH=N0CH3 ch3 L-ld ch3 Η CH (CH3)CH=N0CH3 ch3 L-le ch3 Η CH (CH3) W0CH3 ch3 L-Ii ch3 200407073 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH(CH3)CH:NOCH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=N0CH3 H CH (CH3)CH=NOPr-n H CH (CH3)M0Pr-n H CH (CH3)CH=NOPr-n H CH (CH3)CH=NOPr-n H CH (CH3)CH=NOPr-n H CH (CH3)CH=N0Pr-n H CH(CH3)CH:NOPr - n H CH (CH3)CH=NOPr-n H CH (CH3)CH=NOPr-n H CH (CH3)CH=NOPr-n H CH (CH3)CH=NOPr-n H CH(CH3)C_Pr-n H CH (CH3)CH=N0Pr-n H CH (CH3)CH-NOPr-n H CH (CH3)CH=NOPr-n H CH(CH3)CH:N0Pr-n ch3 L-2b ch3 ch3 L-3d ch3 ch3 L - 3e ch3 ch3 L-3f ch3 ch3 L-31 ch3 ch3 L-3o ch3 ch3 L-4c ch3 ch3 L-45d ch3 ch3 L - 45e ch3 ch3 L-45f ch3 ch3 L - 45g ch3 ch3 L-45ni ch3 ch3 L-46d ch3 ch3 L - 46e ch3 ch3 L-46f ch3 ch3 L-46g ch3 ch3 L-46j ch3 ch3 L-46k ch3 . ch3 L - 46r ch3 ch3 L-47a ch3 ch3 L-47e ch3 ch3 cf3 Ph-4-F ch3 cf3 Ph-4-Cl ch3 cf3 Ph-4_Br ch3 cf3 Ph-4-0CHF2 ch3 cf3 Ph-4-0CF3 ch3 cf3 Ph-4-0S02CH3 ch3 cf3 Ph-4-SCH3 ch3 cf3 Ph+S(0)CH3 ch3 cf3 Ph-4-S02CH3 ch3 cf3 Ph-4-CN ch3 cf3 Ph-3, 4-C12 ch3 cf3 L-46d ch3 Ph-4-F ch3 ch3 Ph-4-Cl ch3 ch3 Ph~4~Br ch3 ch3 Ph-4-CF3 ch3
334 314918 200407073
Η CH (CH3)CH=NOPr-n ch3 Ph_4_0CHF 2 ch3 Η CH (CH3)CH=NOPr-n ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH=NOPr-n ch3 Ph-4-0CF2Br ch3 Η CH (CH3)CH=NOPr-n ch3 Ph-3, 4~C12 ch3 Η CH (CH3)CH=NOCH2Pr-c ch3 Ph-4-OCFs ch3 Η CH (CH3)CH=N0CH2CH20Et ch3 cf3 Ph-4-Cl Η CH (CH3)CH=NOCH,CH2SEt ch3 Ph-4-0CF3 ch3 Η CH (CH3)CH=NOCH2CH=CH2 ch3 cf3 Ph-4-Cl Η CH (CH3)CH=NOCH2Ph ch3 Ph~4~0CF 3 ch3 Η CH (CH3)C(CH3)=N0CH3 ch3 cf3 Ph-4-Cl Η c(ch3) 2ch=noh ch3 cf3 Ph-4-F Η C(CH3) 2ch=noh ch3 cf3 Ph-4-Cl Η C(CH3) 2ch=noh ch3 cf3 Ph-4-Br Η C(CH3) 2ch=noh ch3 cf3 Ph-4_CF3 Η C(CH3) 2ch=noh ch3 cf3 Ph-4-0CHF2 Η C(CH3) 2ch=noh ch3 cf3 Ph-4-0CF3 Η C(CH3) 2ch=noh ch3 Ph-4-F ch3 Η C(CH3) 2ch=noh ch3 Ph-4-Cl ch3 Η C(CH3) 2ch=noh ch3 Ph_4-Br ch3 Η C(CH3) 2ch=noh ch3 Ph-4-CF3 ch3 Η C(CH3) 2ch=noh ch3 Ph-4-0CHF2 ch3 Η C(CH3) 2ch=noh ch3 Ph-4-0CF3 ch3 Η C(CH3) 2ch=noch3 F cf3 Ph-4-C1 Η c(ch3) 2c_ch3 Cl cf3 Ph-4-S02CH Η C(CH3) 2ch=noch3 Cl Ph-4-0CF3 ch3 Η C(CH3) 2ch=noch3 Br cf3 Ph-4-F Η c(ch3) 2c_ch3 ch3 ch3 L-46d Η C(CH3) 2ch=noch3 ch3 Et Ph-4-F Η C(CH3)2CH=NOCH3 ch3 n-Pr Ph-4-S02CH Η C(CH3) 2ch=noch3 ch3 i-Pr L-46d Η C(CH3) 2ch=noch3 ch3 chf2 Ph-4-F Η C(CH3) 2ch=noch3 ch3 cf3 Cl Η C(CH3) 2ch=noch3 ch3 cf3 ch3 Η C(CH3)2CH=NOCH3 ch3 cf3 〇ch3 Η C(CH3)2CH=NOCH3 ch3 cf3 sch3 Η c(ch3) 2ch=noch3 ch3 cf3 N(CH3) 2 Η c(ch3) 2ch:noch3 ch3 cf3 Ph-4~F
335 314918 200407073 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH-NOCH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH:N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2C_CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3)2C_CH3 H C(CH3)2CH=NOCH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH-N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3)2CH=NOCH3 H C(CH3)2CH=NOCH3 H C(CH3) 2C_CH3 H C(CH3)2CH=NOCH3 H C(CH3)2CH=NOCH3 H C(CH3)2C_CH3 H C(CH3)2CH=NOCH3 ch3 cf3 Ph-4-Cl ch3 cf3 Ph~4~Br ch3 cf3 Ph-4-I ch3 cf3 Ph-4-CF3 ch3 cf3 Ph-4-0CHF2 ch3 cf3 Ph-4-0CF3 ch3 cf3 Ph-4-0CF2Br ch3 cf3 Ph-4-0CF2CHF2 ch3 cf3 Ph-4-0CF2CHFCl ch3 cf3 Ph-4-0CF2CHFCF3 ch3 cf3 Ph-4-0CF2CHF0CF3 ch3 cf3 Ph-4-0CF2CHF0CF2CF2CF ch3 cf3 Ph-4-0S02CH3 ch3 cf3 Ph-4-SCH3 ch3 cf3 Ph-4-S (0) CH3 ch3 cf3 Ph-4-S02CH3 ch3 cf3 Ph-4-SEt ch3 cf3 Ph-4-S02Et . ch3 cf3 Ph-4-SPr-i ch3 cf3 Ph-4-S02Pr-i ch3 cf3 Ph-4-SCHF2 ch3 cf3 Ph-4-S02CHF2 ch3 cf3 Ph-4_SCF3 ch3 cf3 Ph+S02CF3 ch3 cf3 Ph-4-SCF2Cl ch3 cf3 Ph-4-S02CF2Cl ch3 cf3 Ph-4-SCF2Br ch3 cf3 Ph-4-S02CF2Br ch3 cf3 Ph-4-N02 ch3 cf3 Ph-4-CN ch3 cf3 Ph-4-C (0) NH2 ch3 cf3 Ph-4-C ⑸ NH2 ch3 cf3 Ph-3,4-F2 ch3 cf3 Ph-3_F-4-C1 ch3 cf3 Ph-3-F-4-CF3 ch3 cf3 Ph-3, 4-Cl2 ch3 cf3 Ph-3-Cl-4-0CF3
336 314918 C(CH3) 2ch=noch3 ch3 cf3 L-14b C(CH3) 2ch=noch3 ch3 cf3 L-14c C(CH3) 2ch=noch3 ch3 cf3 L - 14d C(CH3) 2ch=noch3 ch3 cf3 L-14f C(CH3) 2ch=noch3 ch3 cf3 L - 14h C(CH3) 2ch=noch3 ch3 cf3 L - 24b C(CH3) 2ch=noch3 ch3 cf3 L-24c C(CH3) 2ch=noch3 ch3 cf3 L-24e c(ch3) 2ch=noch3 ch3 cf3 L-36c C(CH3) 2ch=noch3 ch3 cf3 L - 36d C(CH3) 2ch=noch3 ch3 cf3 L-45c c(ch3) 2ch:noch3 ch3 cf3 L-45d C(CH3) 2ch=noch3 ch3 cf3 L-45e C(CH3) 2ch=noch3 ch3 cf3 L-45f C(CH3) 2ch=noch3 ch3 cf3 L - 45g c(ch3) 2ch=noch3 ch3 cf3 L - 45m C(CH3) 2ch=noch3 ch3 cf3 L-46c C(CH3) 2ch=noch3 ch3 cf3 L-46d C(CH3) 2ch=noch3 ch3 cf3 L - 46e C(CH3) 2ch=noch3 ch3 cf3 L-46f C(CH3) 2ch=noch3 ch3 cf3 L-46g C(CH3) 2ch=noch3 ch3 cf3 L - 46j C(CH3) 2ch=noch3 ch3 cf3 L-46k c(ch3) 2ch=noch3 ch3 cf3 L - 46m C(CH3) 2ch=noch3 ch3 cf3 L-46n C(CH3) 2ch=noch3 ch3 cf3 L - 46o C(CH3) 2ch=noch3 ch3 cf3 L-46p C(CH 3) 2ch=noch3 ch3 cf3 L-46r C(CH3)2CH=NOCH3 ch3 cf3 L-47a C(CH3) 2ch=noch3 ch3 cf3 L - 47e C(CH3)2CH=NOCH3 ch3 cf3 L - 48b c(ch3)2ch:noch3 ch3 cf3 L-50b C(CH3) 2ch=noch3 ch3 cf3 L-50c C(CH3)2CH=NOCH3 ch3 cf3 L-50d c(ch3) 2ch=noch3 ch3 CFs L - 50e c.(ch3)2ch=noch3 ch3 cf3 L-50f C(CH3)2CH4i〇CH3 ch3 cf3 L-51b J J /
314918 200407073 Η C(CH3) 2ch=noch3 ch3 cf3 L_51c Η C(CH3) 2ch=noch3 ch3 cf2ci Ph+S02CH Η c(ch3) 2ch:noch3 ch3 cf2cf3 L-46d Η C(CH3) 2ch=noch3 ch3 Ph-4-F ch3 Η C(CH3) 2ch=noch3 ch3 Ph-4-Cl ch3 Η C(CH3) 2ch=noch3 ch3 Ph-4~Br ch3 Η C(CH3) 2ch=noch3 ch3 Ph-4-CF3 ch3 Η C(CH3) 2ch=noch3 ch3 Ph-4-0CHF2 ch3 Η C(CH3) 2ch=noch3 ch3 Ph-4-0CF3 ch3 Η C(CH3) 2ch=noch3 ch3 Ph-4-0CF2Br ch3 Η C(CH3) 2ch=noch3 ch3 Ph-4-0CF2CHF2 ch3 Η c(ch3) 2ch:noch3 ch3 Ph-4-0CF2CHFCl ch3 Η C(CH3) 2ch=noch3 ch3 Ph-4-0CF2CHFCF3 ch3 Η C(CH3) 2ch=noch3 ch3 Ph-4-0CF2CHF0CF3 ch3 Η C(CH3) 2ch=noch3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 ch3 Η C(CH3) 2ch=noch3 ch3 Ph-4_SCF3 ch3 Η C(CH3) 2ch=noch3 ch3 Ph-3, 4-F2 ch3 Η C(CH3)2CH=NOCH3 ch3 Ph-3-F-4-C1 ch3. Η c(ch3) 2ch=noch3 ch3 Ph-3,4-Cl2 ch3 Η C(CH3) 2ch=noch3 ch3 L-lc ch3 Η C(CH3) 2ch=noch3 ch3 L - Id ch3 Η c(ch3) 2ch=noch3 ch3 L - le ch3 Η C(CH3) 2ch=noch3 ch3 L-lf ch3 Η c(ch3) 2ch=noch3 ch3 L-2b ch3 Η C(CH3) 2ch=noch3 ch3 L-3d ch3 Η C(CH3) 2ch=noch3 ch3 L - 3e ch3 Η c(ch3) 2ch=noch3 ch3 L-3f ch3 Η C(CH3) 2ch=noch3 ch3 L-31 ch3 Η C(CH3) 2ch=noch3 ch3 L - 3o ch3 Η c(ch3) 2ch=noch3 ch3 L - 4c ch3 Η C(CH3) 2ch=noch3 ch3 L - 45d ch3 Η C(CH3) 2ch=noch3 ch3 L - 45e ch3 Η C(CH3) 2ch=noch3 ch3 L-45i ch3 Η C(CH3) 2ch=noch3 ch3 L-45g ch3 Η C(CH3) 2ch=noch3 ch3 L-45m ch3 Η C(CH3) 2ch=noch3 ch3 L-46d ch3 Η c(ch3) 2ch=noch3 ch3 L-46e ch3
338 314918 200407073 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH:N0CH3 H C(CH3) 2CH=N0CH3 H C(CH3) 2CH=N0Et
H C(CH3) 2CH=N0CH2C(0) OBu-t H C(CH3)2CH=N0CH2C(0)N(Et)2 H C(CH3) (CH2S02CH3)CH=N0H
H C(CH3) (CH2S02Et)CH=N0H
H CH2CH2CH=NOCH3 H CH (CH3)CH2CH=NOCH3 H H H H H H H H H H H H H H H H H H H H H H H CH3 L-46f CH3 CH3 L-46g CH3 CH3 L-46j CH3 CH3 L-46k CH3 CH3 L-46r CH3 CH3 L-47a CH3 CH3 L-47e CH3 CH3 Ph-4-0CF3 CH3 CH3 CF3 Ph-4-Cl CH3 Ph-4-0CF3 CH3 CH3 CF3 Ph-4-Cl CH3 Ph-4-0CF3 CH3 CH3 CF3 Ph-4-Cl CH3 Ph-4-0CF3 CH3
CH2CH2CH2CH=NOEt ch3 cf3 Ph-4-Cl CH2C(0) OEt ch3 Ph-4-0CF3 ch3 CH (CH3)C(0) OCH3 ch3 cf3 Ph-4-Cl CH (CH3)C(0) OEt ch3 Ph-4-0CF3 ch3. CH2CH2C(0) OEt ch3 gf3 Ph+Cl CH (CH3)CH2C(0) OEt ch3 Ph-4-0CF3 ch3 CH (CH3)C(0)NHEt ch3 cf3 Ph-4-Cl CH (CH3)C(0) NHPr-n ch3 Ph-4-0CF3 ch3 CH (CH3)C(0) NHBu-d ch3 cf3 Ph-4-C1 CH (CH3)C(0)NHCH2Ph ch3 Ph-4-0CF3 ch3 CH (CH3)C(0)N(CH3) 2 ch3 cf3 Ph-4-Cl CH (CH3)C(0)N(Et) 2 ch3 Ph-4-0CF3 ch3 CH (CH3)C(0)N(Pr-n) 2 ch3 cf3 Ph+Cl CH(CH3)C(0) (T-16) ch3 Ph-4-0CF3 ch3 CH(CH3)C(0) (T-17) ch3 cf3 Ph-4-Cl CH(CH3)C(0) (T-18) ch3 Ph~4~0CF 3 ch3 CH(CH3)C(0) (M9) ch3 CF3 Ph-4-Cl CH(CH3)C(0) (T-20) ch3 Ph+OCF3 ch3 CH(CH3)C(0) (T-21) ch3 cf3 Ph-4-Cl CH (CH3)CH2C(0)NHCH3 ch3 Ph-4-0CF3 ch3 CH (CH3)CH2C(0) NHEt ch3 cf3 Ph-4-C1 CH (CH3)CH2C(0)N(CH3) 2 ch3 Ph-4-0CF3 ch3 CH (CH3)CH2C(0)N(Et) 2 ch3 cf3 Ph-4-Cl 339
314918 200407073 H CH (CH3)CH2C(0)N(CH3)Ph
H CH (CH3)CN
H C(CH3)2CN
H C(CH3) 2CN
H C(CH3) 2CN H CH2CH=CH2 ch2ch=ch2ch2ch=ch2 ch2ch=ch2ch2ch=ch2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CM2 H C(CH3)2CH:CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CH=CH2 H C(CH3)2CH=CH2 H C(CH3) 2CH:CH2 H C(CH3)2CH:CH2 H C(CH3) 2C，H=CH2 H C(CH3) 2CH=CH2 H C(CH3) 2CM2 ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 cf3 Ph~4~C1 ch3 cf3 Ph+S02CH3 ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-Cl ch3 cf3 Ph-4-Cl ch3 Ph-4-0CF3 ch3 ch3 cf3 Ph-4-F ch3 cf3 Ph-4-Cl ch3 cf3 Ph_4~Br ch3 cf3 Ph-4-ΐ ch3 cf3 Ph-4-CF3 ch3 cf3 Ph-4-0CHF2 ch3 cf3 Ph-4-0CF3 ch3 cf3 Ph-4-0S02CH ch3 cf3 pm-sch3 ch3 cf3 Ph-4rS (0) CH； ch3 cf3 Ph-4-S02CH3 ch3 cf3 Ph-4-NO2 ch3 cf3 Ph-4-CN ch3 cf3 Ph-4-C (0) NH； ch3 cf3 Ph-4-C (S) NH； ch3 cf3 Ph-3, 4-Cl2 ch3 cf3 L - 46d ch3 cf3 L-46e ch3 cf3 L-46f ch3 cf3 L-46g ch3 Ph-4_F ch3 ch3 Ph-4-Cl ch3 ch3 Ph_4_Br ch3 ch3 Ph-4-CF3 ch3 ch3 Ph-4-0CHF2 ch3 ch3 Ph-4-0CF3 ch3 ch3 Ph-4-0S02CH3 ch3 ch3 Ph-4-SCH3 ch3 ch3 Ph-4-S (0) CH3 ch3 340 314918 200407073 Η C(CH3) 2ch=ch2 ch3 Ph-4-S02CH3 ch3 Η c(ch3) 2ch=ch2 ch3 Ph-4-CN ch3 Η c(ch3) 2ch=ch2 ch3 Ph - 3,4_C12 ch3 Η C(CH3) 2CH=CHC (O)NHEt ch3 Ph-4-0CF3 ch3 Η C(CH3) 2CH=CHPh (E) ch3 cf3 Ph+Cl Η CH2C=CH ch3 Ph-4-0CF3 ch3 CH. ,ch2c=ch ch3 cf3 Ph-4-Cl CH： ^η2ο=οη ch3 cf3 Ph-4-S02CH3 ch3ch2c=ch ch3 Ph-4-Cl ch3 CH： ^η2ο=οη ch3 Ph-4-0CF3 ch3 Η C(CH3) 2c=ch F cf3 Ph-4-S02CH3 Η C(CH3) 2feCH Cl cf3 Ph-4-F * Η C(CH3) 2c=ch Cl Ph-4-0CF3 ch3 Η C(CH3) 2c=ch Br cf3 Ph+Cl Η C(CH3) 2c=ch ch3 ch3 Ph-4-F Η C(CH3) 2feCH ch3 Et Ph-4-Cl Η C(CH3) 2CeCH ch3 n - Pr Ph-4-S02CH3 Η C(CH3) 2c=ch ch3 i-Pr L-46d . Η C(CH3) 2c=ch ch3 chf2 Ph-4-F Η C(CH3) 2CeCH ch3 cf3 Cl Η C(CH3) 2c=ch ch3 cf3 ch3 Η C(CH3) 2c=ch ch3 cf3 〇ch3 Η C(CH3) 2c=ch ch3 cf3 sch3 Η C(CH3) 2CeCH ch3 cf3 n(ch3)2 Η C(CH3) 2C=CH ch3 cf3 Ph-4-F Η C(CH3) 2c=ch ch3 cf3 Ph-4-Cl Η C(CH3) 2c=ch ch3 cf3 Ph-4-Br Η C(CH3) 2c=ch ch3 cf3 Ph-4-I Η C(CH3) 2c=ch ch3 cf3 Ph-4-CF3 Η C(CH3) 2c=ch ch3 cf3 Ph-4-CH2SCH3 Η C(CH3) 2c=ch ch3 cf3 Ph-4-CH2S02CH3 Η C(CH3) 2c=ch ch3 cf3 Ph-4-CH2SCF3 Η C(CH3) 2teCH ch3 cf3 Ph-4-CH2S〇2CF 3 Η C(CH3) 2c=ch ch3 cf3 Ph~4_0CHF 2 Η C(CH3) 2c=ch ch3 cf3 Ph-4-0CF3 Η C(CH3) 2c=ch ch3 cf3 Ph-4-0S02CH3 Η C(CH3) 2CeCH ch3 cf3 Ph-4-SCH3 200407073 H C(CH3) 2_
Η C(CH3) 2feCH
Η C(CH3) 2feCH
H C(CH3) 2CeCH
H C(CH3) 2CeCH
H C(CH3) 2C=CH
H C(CH3) 2CeCH
H C(CH3) 2C=CH
H C(CH3) 2CeCH
H C(CH3) 2C=CH
H C(CH3) 2CeCH
H C(CH3) 2C=CH
H C(CH3) 2C=CH
H C(CH3) 2CeCH H C(CH3) 2_
H C(CH3) 2teCH
H C(CH3) 2CeCH
H C(CH3) 2C=CH
H C(CH3) 2C=CH
H C(CH3) 2feCH
H C(CH3) 2C=CH
H C(CH3) 2feCH
H C(CH3) 2feCH
H C(CH3) 2feCH
H C(CH3) 2teCH
H C(CH3) 2C=CH
H C(CH3) 2C=CH
H C(CH3) 2C=CH
H C(CH3)2C=CH
H C(CH3) 2feCH
H C(CH3) 2C=CH
H C(CH3) 2CeCH
H C(CH3&gt; 2CeCH
H C(CH3) 2C三CH
H C(CH3) 2C=CH
H C(CH3) 2C-CH
H C(CH3) 2C=CH ch3 cf3 Ph - 4-S(0)CH3 ch3 cf3 Ph-4-S02CH3 ch3 cf3 Ph-4-SEt ch3 cf3 Ph-4-S (0)Et ch3 cf3 Ph-4-S02Et ch3 cf3 Ph-4-SPr-n ch3 cf3 Ph+S (0) Pr-n ch3 cf3 Ph-4-S02Pr-n ch3 cf3 Ph-4-SPr-i ch3 cf3 Ph+S(0)Pr-i ch3 cf3 Ph-4-S02Pr-i ch3 cf3 Ph-4-SCHF2 ‘ ch3 cf3 Ph-4-S (0) CHF2 ch3 cf3 PiHhS02CHF2 ch3 cf3 Ph-4-SCF3 ch3 cf3 Ph - 4-S(0)CF3 ch3 cf3 Ph-4-S02CF3 ch3 cf3 Ph-4-SCF2C1 . ch3 cf3 Ph-4-S (0) CF2C1 ch3 cf3 Ph_4-S02CF2C1 ch3 cf3 Ph-4-SCF2Br ch3 cf3 Ph-4-S (0) CF2Br ch3 cf3 Ph_4~S〇2CF2Br ch3 cf3 Ph-4-NO2 ch3 cf3 Ph-4-CN ch3 cf3 Ph-4-C (0) NH2 ch3 cf3 Ph-4-C(S)NH2 ch3 cf3 Ph-3, 4-F2 ch3 cf3 Ph-3-F_4-Cl ch3 cf3 Ph-3-F-4-CF3 ch3 cf3 Ph-3,4-Cl2 ch3 cf3 Ph-3-Cl_4_0CF3 ch3 cf3 L~lc ch3 cf3 L-lf ch3 cf3 L-lg ch3 CFs L - 3c ch3 cf3 L~3h
342 314918 200407073 Η C(CH3)2CeCH ch3 cf3 L-3i Η C(CH3)2CeCH ch3 cf3 L-3j Η C(CH3)2C=CH ch3 cf3 L-3k Η C(CH3)2feCH ch3 cf3 L~3m Η C(CH3)2CeCH ch3 cf3 L-3n Η C(CH3) 2C三CH ch3 cf3 L-4b Η C(CH3) 2CeCH ch3 cf3 L-4e Η C(CH3) 2C=CH ch3 cf3 L-lOb Η C(CH3)2C=CH ch3 cf3 L-lOd Η C(CH3)2CsCH ch3 cf3 L - 14b Η C(CH3) 2feCH ch3 cf3 L-14i Η C(CH3)2C=CH ch3 cf3 L-17a Η C(CH3) 2C三CH ch3 cf3 L-21b Η C(CH3) 2C=CH ch3 cf3 L - 22b Η C(CH3) 2c=ch ch3 cf3 L - 22d Η C(CH3)2feCH ch3 cf3 L-23b Η C(CH3)2CeCH ch3 cf3 L - 23e Η C(CH3)2C=CH ch3 cf3 L - 24b Η C(CH3) 2c=ch ch3 cf3 L-31a Η C(CH3)2C=CH ch3 cf3 L-31c Η C(CH3)2C=CH ch3 cf3 L-36c Η C(CH3) 2c=ch ch3 cf3 L-45c Η C(CH3) 2c=ch ch3 cf3 L-45d Η C(CH3) 2c=ch ch3 cf3 L-46c Η C(CH3) 2c=ch ch3 cf3 L-46d Η C(CH3) 2c=ch ch3 cf3 L-46e Η C(CH3) 2CeCH ch3 cf3 L-46m Η C(CH3)2C=CH ch3 cf3 L-46n Η C(CH3)2C=CH ch3 cf3 L-47a Η C(CH3) 2c=ch ch3 cf3 L-47e Η C(CH3)2C=CH ch3 cf3 L - 50b Η C(CH3) 2c=ch ch3 cf3 L-50c Η C(CH3)2feCH ch3 cf3 L - 50e Η C(CH3) 2c=ch ch3 cf3 L - 50i Η C(CH3) 2c=ch ch3 cf3 L-51b Η C(CH3) 2c=ch ch3 cf3 L - 51c Η C(CH3)2teCH ch3 cf2ci Ph-4-Cl 343
314918 200407073
H C(CH3) 2CeCH
H C(CH3) 2C=CH
H C(CH3)2feCH
H C(CH3) 2C=CH
H C(CH3) 2teCH
H C(CH3)2teCH
H C(CH3) 2CeCH
H C(CH3) 2C=CH
H C(CH3) 2CeCH
H C(CH3) 2feCH H C(CH3) 2_
H C(CH3) 2C=CH
H C(CH3) 2CeCH
H C(CH3)2C=CH
H C(CH3) 2C=CH
H C(CH3)2teCH
H C(CH3)2C=CH
H C(CH3)2C=CH
H C(CH3) 2CeCH
H C(CH3)2C=CH
H C(CH3)2CeCH
H C(CH3) 2C=CH
H C(CH3) 2C=CH
H C(CH3) ,C=CH
H C(CH3) 2CeCH
H C(CH3) 2CeCH H C(CH3) 2_ H C(CH3)2_
H C(CH3)2C=CH
H C(CH3) 2C=CH
H C(CH3)2C=CH
H C(CH3) 2C=CH
H C(CH3)2C=CH
H C(CH3)2CeCH
H C(CH3)2C=CH
H C(CH3)2C=CH
H C(CH3)2feCH CH3 cf2cf3 Ph-4-S02CH3 ch3 Ph-4-F ch3 ch3 Ph-4-Cl ch3 ch3 Ph-4-Br ch3 ch3 Ph-4-1 ch3 ch3 Ph-4-CF3 ch3 ch3 Ph-4-0CHF2 ch3 ch3 Ph-4-0CF3 ch3 ch3 Ph-4-0CF2Br ch3 ch3 Ph-4-0CF2CHF2 ch3 ch3 Ph-4-0CF2CHFCF3 CH3 ch3 Ph-4-CN ch3 ch3 Ph-3, 4-F2 ch3 ch3 Ph-3-F-4-Cl ch3 ch3 Ph-3,4-Cl2 ch3 ch3 L-lc ch3 ch3 L - Id ch3 ch3 L-le ch3 ch3 L-li ch3 ch3 L-2b ch3 ch3 L-3d ch3 ch3 L-3e ch3 ch3 L-3f ch3 ch3 L-31 ch3 ch3 L - 3o ch3 ch3 L-4c ch3 ch3 L - 45d ch3 ch3 L-45e ch3 ch3 L-45f ch3 ch3 L - 45g ch3 ch3 L - 45m ch3 ch3 L-46d ch3 ch3 L-46e ch3 ch3 L-46f ch3 CHa L-46g ch3 ch3 L - 46j ch3 ch3 L-46k ch3
344 314918 200407073 Η C(CH3) 2c=ch ch3 L-46r ch3 Η C(CH3) 2c=ch ch3 L-47a ch3 Η C(CH3) 2teCH ch3 L-47e ch3 Η C(CH3) 2feCPh ch3 cf3 Ph-4-C1 Η C(CH3) 2OC(Ph-4-CH3) ch3 Ph-4-0CF3 ch3 Η C(CH3)2C=C (Ph-4-CF3) ch3 cf3 Ph+Cl Η C(CH3) 2C-C (Ph-4-0CH3) ch3 Ph-4-0CF3 ch3 Η C(CH3) 2C=C (Ph-4-0CF3) ch3 cf3 Ph-4-Cl Η C(CH3) 2CEC(Ph-2,4-F2) ch3 Ph-4-0CF3 ch3 Η C(CH3) 2C^C (Ph-2, 4-Cl2) ch3 cf3 Ph-4-C1 Η C(CH3) 2C=C (Ph-2, 6-Cl2) ch3 Ph-4-OCFs ch3 Η C(CH3) 2C=C(1-Naph) ch3 cf3 Ph-4-Cl Η C(CH3) 2C=C (L-3a) ch3 Ph_4-0CF3 ch3 Η C(CH3)2C=C (L-4a) ch3 cf3 Ph+Cl Η C(CH3)2C=C (L-45a) ch3 Ph-4-0CF3 ch3 Η C(CH3) 2C=C (L-45g) ch3 cf3 Ph-4-Cl Η C(CH3) 2C=C (L~46a) ch3 Ph-4-0CF3 ch3 Η CH2Ph ch3 cf3 P1HK1 ch3 CH2Ph ch3 cf3 Ph+Cl ch3 CH2Ph ch3 Ph+0CF3 ch3 Et CH2Ph ch3 cf3 Ph-4-C1 Et CH2Ph ch3 Ph-4-OCF 3 ch3 Η CH2 (Ph-2-F) ch3 Ph-4-OCF3 ch3 ch3 CH2 (PH-F) ch3 cf3 Ph-4-Cl ch3 CH2 (Ph-2-F) ch3 Ph-4-0CF3 ch3 H CH2 (Ph-2-Cl) ch3 cf3 Ph-4_C1 H CH2 (Ph-3-C1) ch3 Ph-4~0CF3 ch3 ch3 CH2 (Ph-3-Cl) ch3 cf3 Ph+Cl ch3 CH2 (Ph-3-Cl) ch3 Ph-4_0CF3 ch3 H CH2(Ph-4-Cl) ch3 cf3 Ph+Cl H CH2 (Ph-2-CH3) ch3 Ph+OCF3 ch3 H CH2 (Ph+CH3) ch3 cf3 Ph-4-C1 H CH2 (Ph-4-CH3) ch3 Ph - 4~*0CF 3 ch3 H CH2 (Ph-2-CF3) ch3 cf3 Ph+Cl H CH2 (Ph-2-0CH3) ch3 Ph~4~0CF 3 ch3 H CH2 (Ph-3-0CH3) ch3 cf3 Ph-4-Cl H CH2 (Ph-4-0CH3) CHs Ph+OCF3 ch3
345 314918 200407073 Η CH2 (Ph-4-0CF3) ch3 cf3 Ph-4-Cl Η CH2 (Ph-2,3-Cl2) ch3 Ph-4-0CF3 ch3 Η CH2 (Ph-2,4-Cl2) ch3 cf3 Ph，4-Cl Η CH2 (Ph-3,4-Cl2) ch3 Ph-4-0CF3 ch3 Η CH2 (L-45a) ch3 cf3 Ph-4-Cl Η CH2 (L-46a) ch3 Ph-4-0CF3 ch3 Η CH2 (L-47a) ch3 cf3 Ph-4-Cl Η CH (CH3)Ph ch3 Ph-4-0CF3 ch3 Η CH(CH3)Ph(R) ch3 cf3 Ph-4-Cl Η CH (CH3)Ph(R) ch3 cf3 Ph-4-S02CH Η CH (CH3)Ph(R) ch3 Ph-4-0CF3 ch3 Η CH (CH3)Ph (S) ch3 cf3 Ph-4-Cl Η CH (CH3)Ph (S) ch3 Ph-4-0CF3 ch3 Η CH(CH3) (Ph-2-Cl) ch3 cf3 Ph+Cl Η CH(CH3) (Ph-3-C1) ch3 Ph-4-0CF3 ch3 Η CH(CH3) (Ph-4-Cl) ch3 cf3 Ph-4-C1 Η CH(CH3) (L-la) ch3 Ph-4-0CF3 ch3 Η CH(CH3) (L-3a) ch3 cf3 Ph-4-Cl Η CH(CH3) (L-45a) ch3 Ph-4-0CF3 ch3 Η C(CH3) 2Ph ch3 cf3 Ph-4-Cl Η C(CH3) 2 (Ph-3-Cl) ch3 Ph-4-0CF3 ch3 Η C(CH3) 2 (Ph+Cl) ch3 cf3 Ph-4-Cl Η CH2CH2Ph ch3 Ph-4-0CF3 ch3 Η CH2CH2 (Ph-2-Cl) ch3 cf3 Ph-4-Cl Η CH2CH2 (Ph-3-Cl) ch3 Ph-4-0CF3 ch3 Η CH2CH2 (Ph-4-C1) ch3 cf3 Ph-4-Cl Η CH2CH2 (L-46a) ch3 Ph-4-0CF3 ch3 Η C(CH3) 2CH2Ph ch3 cf3 Ph-4-Cl Η CH2CH2CH2Ph ch3 Ph-4-OCF3 ch3 Η och3 ch3 cf3 Ph-4-Cl Η OPr-n ch3 Ph+OCF3 ch3 Η 0CH2CH=CHC1 ch3 cf3 Ph-4-Cl Η OCH2Ph ch3 Ph-4-0CF3 ch3 Η NHCHO ch3 cf3 Ph-4-Cl Η NHC (0) CH3 ch3 Ph-4~0CF3 ch3 Η NHC (0) Ph ch3 cf3 Ph-4-Cl Η NHC (0) OCH3 ch3 Ph~4~0CF 3 ch3 346 314918 200407073 Η NHC (0) OPh ch3 cf3 Ph-4-Cl Η NHC (0) OCH2Ph ch3 Ph-4-OCF3 ch3 Η n(ch3)2 ch3 cf3 Ph+Cl Η N(CH3)CH0 ch3 Ph-4-0CF3 ch3 Η N(CH3)C(0) ch3 ch3 CF3 Ph-4-Cl Η N(CH3)C(0) och3 ch3 Ph-4-0CF3 ch3 Η ch3 ch3 CF3 Ph-4-0 (L-45g) Η ch3 ch3 Ph-4-0(L - 45g) ch3 Η Et ch3 cf3 Ph - 4-0 (L-45g) Η El ch3 cf3 Ph-4-0 (L-451) Η Et ch3 Ph-4-0 (L-45g) ch3 Η n-Pr • ch3 Ph-4 - 0(L-45g) ch3 ' Η i-Pr ch3 ch3 Ph-4-0 (L-45g) Η i-Pr ch3 Et Ph-4-0 (L - 45g) Η i-Pr ch3 chf2 Ph-4-0 (L-45g) Η i-Pr ch3 cf3 Ph-3-0 (L-45e) Η i-Pr ch3 cf3 Ph - 4-0 (L - 45e) Η i-Pr ch3 cf3 Ph - 3-0 (L-45g) Η i-Pr ch3 cf3 Ph-3 - 0(L-451) Η i-Pr ch3 cf3 Ph - 3-0 (L-48b) Η i-Pr ch3 cf3 Ph - 4-0 (L-48b) Η i - Pr ch3 cf2ci Ph-4-0 (L-45g) Η i-Pr ch3 CF2Br Ph-4-0 (L-45g) Η i-Pr ch3 CF2CF3 Ph-4-0 (L-45g) Η i-Pr ch3 Ph-4-0CHF2 och3 Η i-Pr ch3 Ph-4-0 (Ph-4-Cl) ch3 Η i-Pr ch3 Ph-4-0 (Ph-4-Cl) och3 Η i-Pr ch3 Ph-4-0(P 卜4-Br) ch3 Η i-Pr ch3 Ph-4-0 (Ph-4-Br) och3 Η i-Pr ch3 Ph-4-0(L-21c) ch3 Η i-Pr ch3 Ph+0(L-21c) och3 Η i-Pr ch3 Ph-4-0(L-21e) ch3 Η i-Pr ch3 Ph-4-0 (L-21e) och3 Η i-Pr ch3 Ph-4-0 (L-45e) ch3 Η i-Pr ch3 Ph~4~0 (L~45e) och3 Η i-Pr ch3 Ph - 3-0(L-45g) ch3 Η i-Pr ch3 Ph-3-0 (L-451) ch3
347 314918 200407073 Η i-Pr Η i-Pr Η i-Pr Η i-Pr Η i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr HPr i-Pr Η CH3 Ph-4-0(L-451) 0CH3 CH3 Ph-4-0 (L-48b) CH3 CH3 Ph-4-0 (L-48b) 0CH3 CH3 Ph - 4-S(Ph-4-Cl) CH3 CH3 Ph-4-S (Ph-4-Br) CH3 CH3 Ph-4-S(Ph-4-CF3) CH3 CH3 Ph-4-S(Ph-4-CF3) 0CHa CH3 Ph-4-S (L-21c) CH3 CH3 Ph-4-S (L~21e) CH3 CH3 Ph-4-S (L - 45e) CH3 CH3 Ph - 3-S(L - 45g) CH3 CH3 Ph-4-S (L-45g) CH3 CH3 Ph-4 - S(L - 45g) 0CH3 CH3 Ph-3 - S(L - 451) CH3 CH3 Ph-4 - S(L-451) CH3 CH3 Ph-4-S (L-48b) CH3
Et Ph+0(L-45g) CH3 CH20H Ph-4-0 (L-45g) CH3 H c - Pr ch3 Ph-4 - 0 (L-45g) ch3 H s-Bu ch3 cf3 Ph - 4-0(L - 45g) H s - Bu ch3 Ph-4-0CF2CHF0CF2CF2CF3 CH3 H s - Bu ch3 Ph-4 - 0 (L - 45g) ch3 H t - Bu ch3 cf3 Ph-4 - 0 (L - 45g) H t - Bu ch3 Ph-4-0CF2CHF0CF2 cf2cf3 ch3 H t_Bu ch3 Ph-4-0 (L-45g) ch3 H C_3)Pr - n ch3 Ph-4-0 (L - 45g) ch3 H C(CH3) 2Pr-!l ch3 Ph-4-0 (L-45g) ch3 H CH2C(CH3) 2〇Si (CH3) a ch3 Ph-4-0 (L-45g) ch3 H CH (CH3)CH20CH3 ch3 cf3 Ph-4-0 (L-45e) H ch(ch3)ch2och3 ch3 cf3 Ph-4-0 (L-45g). H CH (CH3)CH20CH3 ch3 cf3 Ph - 4 一0(L_451) H CH (CH3)CH20CH3 ch3 cf3 Ph - 4-0 (L-48b) H CH (CH3)CH20CH3 ch3 Ph+0 (L-45g) ch3 H CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-0CF2CHF0CF H CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4 - 0(L-45g) H CH (CH3)CH20C (0) ch3 ch3 PH-0 (L - 45g) ch3 H CH (CH3)CH20C (0)NHCH3 ch3 cf3 Ph-4-0 (L-45g) 348 314918 200407073 Η CH (CH3)CH20C (0) nhch3 ch3 cf3 Ph-4-0 (L-451) Η CH (CH3)CH20C (0) nhch3 ch3 Ph-4-0 (L-45g) ch3 Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph - 4 一0(L - 45e) Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-4 - 0(L - 45g) Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph - 4-0(L - 451) Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-4-0 (L-48b) Η CH (CH3)CH20C (0) NHEt ch3 Ph-4-0(L-45g) ch3 Η CH (CH3)CH20C (0) NHPr-n ch3 cf3 Ph-4-0CF2CHF0CF Η CH (CH3)CH20C (0) NHPr-n ch3 cf3 Ph-4-0 (L-45g) Η CH (CH3)CH20C (0) NHPr-n ch3 Ph-4-0 (L-45g) ch3 Η CH (CH3)CH20C (0) NHPr-i ch3 cf3 Ph-4-OCF2CHFOCF Η CH (CH3)CH20C (0) NHPr-i ch3 cf3 Ph-4-0 (L-45g) Η CH (CH3)CH20C (0) NHPr^i ch3 Ph-4-0 (L-45g) ch3 Η CH (CH3)CH20C (0) NHPr-c ch3 cf3 Ph_4_0CF2CHF0CF Η CH (CH3)CH20C (0) NHPr-c ch3 cf3 Ph - 4-0(L - 45g) Η CH (CH3)CH20C (0) NHPr-c ch3 Ph_4-0 (L - 45g) ch3 Η CH (CH3)CH20C (0) NHCH2Ph ch3 cf3 Ph-4-0CF2CHF0CF Η CH (CH3)CH20C (0) NHCH2Ph ch3 cf3 Ph-4-0 (L-45g) Η CH (CH3)CH20C (0) NHCH2Ph ch3 Ph-4-0 (L-45g) ch3 Η CH (CH3)CH20C (0) NHPh ch3 cf3 Ph-4-OCF2CHFOCF Η CH(CH3)CH20C(0)NHPh ch3 cf3 Ph-4 - 0 (L - 45g) Η CH (CH3)CH20C (0) NHPh ch3 Ph-4~0 (L-45g) ch3 Η CH (CH3)CH20C (0)N(Et)2 ch3 cf3 Ph-4_0CF2CHF0CF Η CH (CH3)CH20C (O)N(Et) 2 ch3 cf3 Ph - 4-0 (L - 45g) Η CH (CH3)CH2OC (O)N(Et) 2 ch3 Ph-4-0 (L~45g) ch3 Η CH(CH3)CH2OP ⑸（och3)2 ch3 cf3 Ph-4-0CF2CHF0CF: Η ch(ch3)ch2op(s) (och3) 2 ch3 cf3 Ph-4 - 0(L - 45g) Η CH(CH3)CH2OP(S) (OCH3) 2 ch3 Ph-4-0 (L-45g) ch3 Η CH(CH3)CH2OP⑸（OEt)2 ch3 cf3 Ph-4-0CF2CHF0CF; Η CH(CH3)CH2OP(S) (OEt)2 ch3 cf3 Ph-4~0 (L-45g) Η CH(CH3&gt;CH2OP ⑸（OEt)2 ch3 Ph-4 - 0 (L-45g) ch3 Η CH(CH3)CH20(Ph-4 - Cl) ch3 Ph-4-0 (L-45g) ch3 Η C(CH3) 2ch2och3 ch3 cf3 Ph-4-0 (L-45e) Η C(CH3)2CH2OCH3 ch3 cf3 Ph-4-0 (L-45g) Η c.(ch3) 2ch2och3 ch3 cf3 Ph-4-0 (L-451) Η c(ch3)2ch2och3 c.h3 cf3 Ph-4-0 (L-48b) Η c(ch3)2ch2och3 ch3 Ph-4 - 0 (L-45g) ch3
349 314918 200407073 H C(CH3) 2ch2oc (0)NHCH3 H C(CH3) 2CH20C (0)NHCH3 H C(CH3) 2CH20C (0)NHCH3 H C(CH3) 2CH20C (0)NHCH3 H C(CH3) 2CH20C (0)NHCH3 H C(CH3) 2CH20C (O)NHEt H C(CH3) 2CH2OC (O)NHEt H C(CH3) 2CH2OC (〇}NHEt H C(CH3) 2CH2OC (O)NHPr-n H C(CH3) 2CH2OC (0) NHPr-n H C(CH3) 2CH2OC (0)NHPr~n H C(CH3) 2CH2OC (O)NHPr-n H C(CH3) 2CH2OC (O)NHPr-n H C(CH3) 2CH2OC (0) NHCH2Ph H C(CH3) 2CH2OC (0) NHCH2Ph H C(CH3) 2CH2OC (0)NHCH2Ph H C(CH3) 2CH2OC (0)NHCH2Ph H C(CH3) 2CH2OC (0)NHCH2Ph H C(CH3) 2CH2OC (0)N(CH3) 2 H C(CH3) 2CH2OC (0)N(CH3) 2 H C(CH3)2CH20C(0)N(CH3)2 H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH2OEt H CH (CH3)CH2CH2OEt H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 ch3 cf3 PM - 0 (L - 45e) ch3 cf3 Ph-4-0 (L-45g) ch3 cf3 Ph+0(L-451) ch3 cf3 Ph+O (卜 48b) ch3 PJi-4-0 (L - 45g) ch3 ch3 cf3 Ph - 4-0 (L-45g&gt; ch3 cf3 Ph-4-0 (L-451) ch3 Ph-4-0 (L-45g) ch3 ch3 cf3 Ph-4-0CF2CHF0CF ch3 cf3 Ph-4-0 (L-45g) ch3 Ph+OCF2CHF2 ch3 ch3 Ph-4-0CF2CHFCF3 ch3 ’ ch3 Ph - 4-0 (L-45g) ch3 ch3 cf3 Ph-4-0CF2CHF0CF ch3 cf3 Ph - 4-0 (L-45g) ch3 Ph-4-0CF2CHF2 ch3 ch3 Ph-4-0CF2CHFCF3 ch3 ch3 Ph-4 - 0 (L-45g) ch3 . ch3 cf3 Ph-4-0CF2CHF0CF ch3 cf3 Ph-4-0 (L-45g) ch3 Ph-4 - 0 (L - 45g&gt; ch3 ch3 cf3 Ph-4-0CF2CHF0CF ch3 cf3 Ph-4 - (ML-45g) ch3 Ph-4-0 (L-45g) ch3 Cl Ph-4-0 (L-45g) ch3 ch3 ch3 Ph-4-0 (L-45g) ch3 ch3 Ph-4-0 (L - 451) ch3 chf2 Ph-4-0CF2CHF0CF ch3 chf2 Ph-4-0 (L-45g) ch3 cf3 Ph - 3-0(Ph - 4-C1) ch3 cf3 Ph+0(Ph+Cl) ch3 cf3 Ph - 3-0(Ph-4 - Br) ch3 cf3 Ph-4-0(Ph-4-Br) ch3 cf3 Ph-4-0 (L-45e) ch3 cf3 Ph - 4-0(L-48b) ch3 cf3 Ph-3-S (Ph-4-Cl) ch3 cf3 Ph-4-S(Ph-4-Cl)
350 314918 200407073 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2SCH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S(0) CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2SEt H CH (CH3)CH2S(0)Et H CH (CH3)CH2S(0)Et H CH (CH3)CH2S(0)Et H CH (CH3)CH2S02Et H CH (CH3)CH2S02Et H CH (CH3)CH2S02Et H CH (CH3)CH2SSCH3 H CH (CH3)CH2SSCH3 H CH (CH3)CH2SSCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3
Ph-3-S (Ph-4-Br) Ph-4-S (Ph-4-Br) Ph-4 一 S (L-45e) Ph-4-S (L_45g) Ph-4 - S(L-451) Ph-4-S (L-48b) Cl 0CH3 Ph-4-0 (L-45e) Ph-4-0 (L-48b) Cl 0CH3 ’ Ph-4-0 (L-45g) Ph - 4_0 (L - 45g) Ph - 4-0 (L-45e) Ph-4-0 (L-48b) Cl 〇CH3 . Ph-4-0CF2CHF0CF3 Ph-4-0 (L-45g) CH3 Ph-4-0CF2CHF0CF3 Ph - 4-0 (L-45g) CH3 Ph-4-0CF2CHF0CF3 Ph-4-0(L - 45g) CH3 Ph-4-0CF2CHF0CF3 Ph-4-0 (L-45g) CH3 ch3 Ph-4-0 (L-45g) Ph-4-0(L_451) Ph-4-0CF2CHF0CF3 Ph_4 - 0(L-45g) Ph-3-0 (Ph-4-Cl) Ph-4-0 (Ph-4-Cl)
ch3 c,f3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 Ph-4-0 (L-45g) ch3 Ph-4-0 (L-45g) ch3 cf3 ch3 cf3 ch3 Ph-4-0 (L-45g) ch3 Ph-4-0 (L~45g) ch3 ch3 ch3 chf2 ch3 cf3 ch3 cf3 ch3 Ph-4-0 (L-45g) ch3 Ph - 4-0 (L - 45g) ch3 cf3 ch3 cf3 ch3 Ph - 4 一0 (L - 45g) ch3 cf3 ch3 cf3 ch3 Ph-4 - 0 (L - 45g) ch3 cf3 ch3 cf3 ch3 Ph-4 - 0 (L - 45g) ch3 cf3 ch3 cf3 ch3 Ph - 4 -0 (L-45g) Cl Ph-4-0 (L-45g) ch3 ch3 ch3 ch3 ch3 chf2 ch3 chf2 ch3 cf3 ch3 cf3 351 314918 200407073 Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3-0 (Ph-4-Br) Η c(ch3&gt; 2ch2sch3 ch3 cf3 Ph-4-0 (Ph-4-Br) Η C(CH3) 2ch2sch3 ch3 cf3 Ph-4 - 0 (L - 45e) Η c(ch3) 2ch2sch3 ch3 cf3 Ph_4-〇 (L - 48b) Η c(ch3) 2ch2sch3 ch3 cf3 Ph-3-S (Ph&gt;4-Cl) Η c(ch3) 2ch2sch3 ch3 cf3 Ph-4 - S(Ph-4_C1) Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3-S (Ph-4-Br) Η c(ch3) 2ch2sch3 ch3 cf3 Ph-4-S(Ph-4 - Br) Η C(CH3) 2ch2sch3 ch3 cf3 Ph-4-S (L-45e) Η C(CH3) 2ch2sch3 ch3 cf3 Ph-4-S (L-45g) Η c(ch3) 2ch2sch3 ch3 cf3 Ph - 4-S(L-451) Η C(CH3) 2ch2sch3 ch3 cf3 Ph-4-S (L-48b) Η C(CH3) 2ch2sch3 ch3 Ph-4-0 (L-45g) Cl Η C(CH3) 2ch2sch3 ch3 Ph-4-0 (L-45g) 〇ch3 Η C(CH3) 2CH2S(0)CH3 ch3 cf3 Ph-4-0 (L - 45e) Η c(ch3) 2ch2s(o)ch3 ch3 cf3 Ph-4-0 (L-48b) Η C(CH3) 2CH2S(0) ch3 ch3 Ph-4-0 (L-45g) Cl Η C(CH3) 2CH2S(0) ch3 ch3 Ph-4-0 (L-45g) 0CH3 Η C(CH3) 2ch2so2ch3 ch3 ch3 Ph-4-0 (L-45g) Η C(CH3) 2ch2so2ch3 ch3 chf2 Ph-4-0 (L-45g) Η C(CH3) 2ch2so2ch3 ch3 cf3 Ph-4-0 (L - 45e) Η C(CH3) 2ch2so2ch3 ch3 cf3 Ph-4 - 0 (L - 48b) Η C(CH3) 2ch2so2ch3 ch3 Ph-4-0 (L_45g) Cl Η C(CH3) 2ch2so2ch3 ch3 Ph-4-0 (卜45g) 〇ch3 Η C(CH3) 2CH2SEt ch3 cf3 Ph-4-0CF2CHF0CF3 Η C(CH3)2CH2SEt ch3 cf3 Ph-4-0 (L-45g) Η C(CH3)2CH2SEt ch3 Ph-4-0 (L-45g) ch3 Η C(CH3) 2CH2S(0)Et ch3 cf3 Ph-4-0CF2CHF0CF3 Η C(CH3) 2CH2S(0)Et ch3 cf3 Ph - 4-0(L-45g) Η C(CH3)2CH2S(0)Et ch3 Ph - 4-0 (L-45g) ch3 Η C(CH3)2CH2S02Et ch3 cf3 Ph-4-0CF2CHF0CF3 Η C(CH3) 2CH2S02Et ch3 cf3 Ph-4-0 (L~45g) Η C(CH3)2CH2S02Et ch3 Ph-4-0 (L-45g) ch3 Η CH (CH3)CH2N(CH3)S02CH3 ch3 cf3 Ph-4-0 (L-45e) Η CH (CH3)CH2N(CH3)S02CH3 ch3 cf3 Ph-4-0 (L-45g) Η CH (CH3)CH2N(CH3)S02CH3 ch3 cf3 Ph-4-0 (L-451) Η ch(ch3)ch2n(ch3)so2ch3 ch3 cf3 Ph - 4-0(L - 48b)
352 314918 200407073 Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph - 4-0(L - 45g) ch3 Η CH (CH3)CH=N0CH3 ch3 cf3 Ph-4-0 (L-45e) Η CH (CH3)CH=N0CH3 ch3 cf3 Ph-4-0 (L-45g) Η CH (CH3)CH=N0CH3 ch3 cf3 Ph_4 - 0(L - 451) Η CH (CH3) CH=N0CH3 ch3 cf3 Ph - 4-0 (L-48b) Η CH (CH3)CH=N0CH3 ch3 Ph-4-0 (L-45g) ch3 Η C(CH3) 2ch=noch3 ch3 cf3 Ph-4-0 (L-45e) Η C(CH3) 2ch=noch3 ch3 cf3 Ph-4-0 (L-45g) Η C(CH3) 2ch=noch3 ch3 CF3 Ph-4-0 (L-451) Η C(CH3) 2ch=noch3 ch3 cf3 Ph-4-0 (L-48b) Η C(CH3) 2ch=noch3 ch3 Ph-4-0 (L-45g) ch3 Η C(CH3) 2ch=ch2 ch3 cf3 Ph-4-0 (L-45g) Η C(CH3) 2c=ch ch3 cf3 Ph-4-0 (L-45g) Η C(CH3) 2c=ch ch3 Ph-4-0 (L-45g) ch3 下述第3表中，表示取代基（X)m及（Y)n之取代位置之 編號，分別對應於下述構造式中記載之編號之位置，「-」 之記號表示無取代。 353 314918 200407073 第3表
ch3 ch3 [2]-1 , [2]·2
[2]-3 ， [2]-4
[2]-5
ch3 ch3 [2]-6 354 314918 200407073
CH3 ch3 [2]-7 R5
ch3 [2]-9
ch3p】-ll
355 314918 200407073
ch3 ch3 [2] - 13 R6^
CH3 ch3 [2] - 14
ch3 [2] 16
CH3 ch3 [2]-17 , [2] - 18 356 314918 200407073
ch3 ch3 [2] · 20
CH3 ch3 [2] 21
[2] - 22
CH3 [2] 23
CH3 m · 24 357 314918 200407073
ch3 [2] - 25
[2] - 26
[2] - 29
CH3 [2] - 30 358 314918 200407073 (Y)n3 R4 R6aRft
丫〜s(o)ch3 ch3 [2】-31
ch3 ch3 [2] - 33 R6^
C ^^^S(0)CK3 CH3 CH3 [2] 34
CH3 ch3 [2】· 35 359 314918 200407073 (Y)n R4 — 2-CH3 cf3 一 2-CH3 cf3 一 2-CH3 cf3 — 2 - CH3 cf3 — 2-CH3 cf3 - 2-CH3 cf3 — 2-CH3 cf3 一 2-CH3 cf3 一 2-CH3 cf3 — 2-CH3 cf3 — 2-CH3 Ph-4-F 一 2 - CH3 Ph-4-Cl — 2-CH3 Ph-4-Br — 2-CH3 Ph-4-CF3 一 2-CH3 Ph-4-0CHF2 一 2 - CH3 Ph-4-0CF3 — 2 - CH3 Ph-3, 4-Cl2 5-F 2-CH3 cf3 5-F 2-CH3 Ph-4-0CF3 6-F 2-CH3 cf3 6-F 2-CH3 cf3 6-F 2 - ch3 cf3 6-F 2 - CH3 cf3 6-F 2-CH3 cf3 6-F 2-CH3 cf3 6-F 2-CH3 cf3 6-F 2-CH3 cf3 6-F 2-CH3 cf3 6-F 2-CH3 CF3 6-F 2 - CH3 cf3 6-F 2-CH3 cf3 6~F 2 - CH3 cf3 6-F 2-CH3 Ph-4-F 6-F 2-CH, Ph-4-Cl R6a R6b R5 H H Ph-4-F H H Ph-4-C1 H H Ph-4-Br H H Ph-4-0CF3 H H Ph-4-SCH3 H H Ph-4 - S(0)CH H H Ph-4-S02CH3 H H Ph-4-CN H H Ph-3, 4-Cl2 H H L-46d H H ch3 H H ch3 H H ch3 H H ch3 H H ch3 H H ch3 H H ch3 H H Ph-4-F H H ch3 H H Ph-4-F H H Ph-4-Cl H H Ph-4-Br H H Ph-4-0CF3 H H Ph-4-0S02CH H H Ph-4-SCH3 H H Ph-4-S (0) CH； H H Ph-4~S02CH3 H H Ph-4-CN H H Ph-3, 4-Cl2 H H L - 46d H H L - 47a H H L - 47e H H ch3 H H ch3 360 314918 200407073 6-F 2 - CH3 Ph-4-Br H H ch3 6-F 2-CH3 Ph-4-I H H ch3 6-F 2-CH3 Ph-4-CF3 H H ch3 6-F 2-CH3 Ph-4-0CHF2 H H ch3 6-F 2-CH3 Ph-4-0CF3 H H ch3 6-F 2-CH3 Pli+CN H H ch3 6-F 2-CH3 Ph - 3,4-Cl2 H H ch3 3, 4-F2 2-CH3 cf3 H H Ph-4-Cl 3,4-F2 2 - CH3 cf3 H H Ph_4_Br 3,4-F2 2-CH3 cf3 H H Ph+0CF3 3, 4-F 2 2 - CH3 cf3 H H Ph-4-S02CH3 3,4-F2 2 - CH3 Ph-4-0CF3 H H ch3 ' 3,6-F2 2 - CH3 cf3 H H Ph-4-C1 4, 5-F2 2 - CH3 cf3 H H Ph-4-CI 4, 5_F2 2-CH3 Ph-4-0CF3 H H ch3 4-C1 2-CH3 cf3 H H Ph+Cl 4 - Cl 2-CH3 Ph-4-0CF3 H H ch3 5-C1 2 - CH3 cf3 H H Ph+Cl · 6 - Cl 2 - CH3 cf3 H H Ph+F 6-C1 2-CH3 cf3 H H Pti-4-Cl 6-C1 2-CH3 cf3 H H Ph-4-Br 6-C1 2-CH3 cf3 H H Ph-4-I 6-C1 2-CH3 cf3 H H Ph-4-CF 3 6 - Cl 2-CH3 cf3 H H Ph-4-0CHF2 6-C1 2 - CH3 cf3 H H Ph-4-0CF3 6-C1 2-CH3 cf3 H H Ph-4_0CF2Br 6-C1 2 - CH3 cf3 H H Ph-4-0CF2CHF2 6-C1 2-CH3 cf3 H H Ph-4-0CF2CHFCF 6-C1 2 - CH3 cf3 H H Ph-4-0S02CH3 6 - Cl 2-CH3 cf3 H H Ph+SCH3 6-C1 2-CH3 CFs H H Ph-4-S (0) CH3 6 - Cl 2-CHa cf3 H H Ph+S02CH3 6-C1 2-CH3 cf3 H H Ph-4-N02 6-C1 2-CH3 cf3 H H Ph-4-CN 6-C1 2-CHa cf3 H H Ph - 4-C(0)NH2 6-C1 2-CH3 CFs H H Ph-4-C(S)NH2 6-C1 2 - CH3 cf3 H H Ph-3, 4-F2
361 314918 200407073 6-C1 2-CH3 cf3 H H Ph-3-F~4_C1 6-Cl 2-CH3 cf3 H H Ph-3,4-Cl2 6-C1 2-CH3 cf3 H H L - 46d 6-Cl 2 - CH3 cf3 H H L - 47a 6-Cl 2 - CH3 cf3 H H L-47e 6-Cl 2-CH3 Ph-4-F H H ch3 6-Cl 2 - CH3 Ph-4-Cl H H ch3 6 - Cl 2-CH3 Ph-4-Br H H ch3 6-C1 2 - CH3 Ph-4-I H H ch3 6-C1 2-CH3 Ph-4-CF3 H H ch3 6 - Cl 2-CH3 Ph-4-0CHF2 H H ch3 6-Cl 2-CH3 Ph-4-0CF3 H H ch3 6-C1 2-CH3 Ph-4-0CF2Br H H ch3 6-Cl 2-CH3 Ph-4-0CF2CHF2 H H ch3 6-C1 2-CH3 Ph-4-0CF2CHFCF3 H H ch3 6-C1 2-CH3 Ph-4-CN H H ch3 6-Cl 2-CH3 Ph-3, 4-F2 H H ch3 6-C1 2 - CH3 Ph-3_F-4-Cl H H ch3 6-Cl 2 - CH3 Ph-3,4-Cl2 H H ch3 6-C1 2 - CH3 L - lc H H ch3 6-C1 2-CH3 L - Id H H ch3 6-C1 2 - CH3 L-le H H ch3 6-Cl 2-CH3 L- li H H ch3 6-Cl 2-CH3 L-2b H H ch3 6-Cl 2 - CH3 L_3d H H ch3 6-Cl 2-CH3 L - 3e H H ch3 6-C1 2-CH3 L-3f H H ch3 6-C1 2-CH3 L-31 H H ch3 6-Cl 2-CH3 L-3o H H ch3 6 - Cl 2 - CH3 L - 4c H H ch3 3-Cl-4-F 2 - CH3 cf3 H H Ph-4-Cl 3-CH-F 2-CH3 cf3 H H Ph-4-Br 3-Cl-4-F 2 - CH3 cf3 H H Ph-4_0CF3 3-C 卜4 -F 2-CH3 cf3 H H Ph-4-S02CH3 3-C1-4-F 2 - CH3 Ph-4-0CF3 H H ch3 3, 4-Cl2 2 - CH3 cf3 H H Ph-4-F 3, 4-Cl 2 2-CH3 cf3 H H Ph-4-Cl
362 314918 200407073 3,4-Cl2 2-CH3 cf3 H H Ph-4-Br 3, 4-Cl 2 2-CH3 cf3 H H Ph-4-1 3,4-Cl2 2-CH3 cf3 H H Ph-4-CF3 3, 4-Cl 2 2 - CH3 cf3 H H Ph-4-0CHF2 3, 4-Cl 2 2-CH3 cf3 H H Ph~4-0CF3 3, 4-Cl2 2-CH3 cf3 H H Ph-4-0CF2Br 3, 4-Cl2 2 - CH3 cf3 H H Ph-4-0CF2CHF2 3,4-Cl2 2-CH3 cf3 H H Ph-4-0CF2CHFCl 3, 4-Cl 2 2 - CH3 cf3 H H Ph-4-0CF2CHFCF3 3, 4-Cl2 2 - CH3 cf3 H H Ph-4-0CF2CHF0CF3 3,4-Cl2 2-CH3 cf3 H H Ph_4-0CF2CHF0CF2CF2CF 3,4-Cl2 2-CH3 cf3 H H Ph-4-OS02CH3 ' 3,4-Cl2 2-CH3 cf3 H H Ph+SCH3 3, 4-Cl2 2 - CH3 cf3 H H Ph-4-S (0) CH3 3, 4-Cl 2 2 - CH3 cf3 H H Ph-4-S02CH3 3, 4-Cl 2 2 - CH3 cf3 H H Ph-4-N02 3, 4-Cl 2 2 - CH3 cf3 H H Ph-4-CN 3,4-Cl2 2-CH3 cf3 H H Ph - 4_C(0)NH2. 3, 4-Cl 2 2-CH3 cf3 H H Ph-4-C (S)NH2 3,4-Cl2 2-CH3 cf3 H H Ph-3, 4-Cl2 3, 4-Cl 2 2-CH3 cf3 H H L - 46d 3, 4-Cl 2 2 - CH3 cf3 H H L - 47a 3, 4-Cl 2 2-CH3 cf3 H H L-47e 3, 4-Cl2 2-CH3 Ph-4-F H H ch3 3, 4-Cl 2 2 - CH3 Ph-4-Cl H H ch3 3, 4-Cl2 2-CH3 Ph-4-Br H H ch3 3,4-Cl2 2-CH3 Ph-4-1 H H ch3 3, 4-Cl2 2-CH3 Ph-4-CF3 H H ch3 3, 4-Cl2 2 - CH3 Ph-4-0CHF2 H H ch3 3, 4-Cl2 2 - CH3 Ph-4-0CF3 H H ch3 3, 4-Cl 2 2-CH3 Ph-4-0CF2Br H H ch3 3,4-Cl2 2-CH3 Ph-4_0CF2CHF2 H H ch3 3, 4-C12 2 - CH3 Ph-4-0CF2CHFCF3 H H ch3 3, 4-Cl 2 2-CH3 Ph-3,4-Cl2 H H ch3 3,5-Cl2 2-CH3 Ph-4-0CF3 H H ch3 3,6-Cl2 2 - CH3 cf3 H H Ph-4-Cl 5, 6-Cl2 2-CH3 cf3 H H P1H-C1
λ (λ 314918 200407073 6 - Br 2-CH3 cf3 6 - Βγ 2-CH3 cf3 6-Br 2-CH3 cf3 6-Br 2-CH3 cf3 6-Βγ 2-CH3 cf3 6-Br 2 - CH3 cf3 6-Br 2-CH3 cf3 6 - Br 2 - CH3 cf3 6-Br 2-CH3 cf3 6-Br 2-CH3 cf3 6 - Br 2-CH3 cf3 6~Br 2-CH3 cf3 6-Br 2 - CH3 cf3 6-Br 2 - CH3 Ph-4-F 8-Br 2-CH3 Ph-4-Cl 6-Br 2 - CH3 Ph-4-Br 6~Br 2 - CH3 Ph-4-CF3 6-Br 2 - CH3 Ph-4-0CHF2 6-Br 2 - CH3 Ph-4-0CF3 6-Br 2 - CH3 Ph-3, 4-Cl2 3, 4-Br2 2-CHa cf3 3,4-Br2 2-CH3 cf3 3, 4~Br 2 2 - CH3 Ph-4-0CF3 3，6-Br2 2-CH3 cf3 3，6-Br2 2-CH3 Ph-4-0CF3 5，6-Br2 2 - CH3 cf3 3-1 2 - CH3 H 3-1 2-CH3 H 3-1 2 - CH3 ch3 3-1 2 - CH3 ch3 3-1 2 - CH3 Et 3-1 2 - CH3 n-Pr 3-1 2-CH3 i - Pr 3-1 2 - CH3 -CH2CH2CH2_ 3-1 2 - CH3 -ch2ch2ch2- 3-1 2-CH3 -ch2ch2ch2ch2- 3-1 2-CH3 -ch2ch2ch2ch2- H H Ph-4-F H H Ph-4-Cl H H Ph-4-Br H H Ph-4_0CF3 H H Ph-4-0S02CH H H Ph-4-SCH3 H H Ph-4-S (0) CH: H H Ph-4-S02CH3 H H Ph-4-CN H H Ph~3, 4-Cl 2 H H L_46d H H L-47a H H L-47e H H ch3 U H ch3 H H ch3 H H ch3 H H ch3 H H ch3 H H ch3 H H Ph+Cl H H Ph-4-S02CH3 H H ch3 H H Ph+Cl H H ch3 H H Ph-4-Cl ch3 H Ph-4-Cl ch3 ch3 Ph-4-S02CH3 ch3 H Ph-4-Cl ch3 ch3 Ph+S02CH3 ch3 H Ph-4-Cl ch3 H Ph-4-S02CH3 ch3 H Ph-4-Cl H Ph-4-Cl H Ph+S02CH3 H Ph-4-Cl H Ph-4-S02C:H3
364 314918 200407073 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3-1 3] 3-1 3-1 3-1 3-1 2 - CH3 CHF2 CH3 2-CH3 CF3 F 2 - CH3 CF3 F 2-CH3 CF3 ch3 2-ch3 CF3 ch3 2-CH3 cf3 ch3 2-CH3 cf3 ch3 2-CH3 CF3 CH3 2-CH3 CF3 CH3 2-CH3 cf3 ch3 2-CH3 cf3 ch3 2-CH3 cf3 ch3 2-CH3 cf3 ch3 2-CH3 CF3 CH3 2-CH3 cf3 ch3 2 - CH3 CF3 CH3 2-CH3 CF3 CH3 2 - CH3 CF3 CH3 2-CH3 cf3 ch3 2-CH3 CF3 CH3 2-CH3 cf3 ch3 2-CH3 cf3 ch3 2-CH3 cf3 ch3 2-CH3 cf3 ch3 2-CH3 cf3 ch3 2-CH3 cf3 ch3 2-CH3 cf3 ch3 2-CH3 cf3 ch3 2-CH3 CF3 CH3 2 - CH3 CF3 CH3 2-CH3 cf3 ch3 2-CH3 cf3 ch3 2-CH3 cf3 ch3 2-CH3 cf3 ch3 2-CH3 cf3 ch3 2-CH3 CF3 Et 2-CH3 CF3 n-Pr
H F
Ph-4-S02CH3 Ph-4-C1 . Ph-4-S02CH3 Ph-4-F Ph+Cl Ph_4-Br Ph-4-I Ph-4-CF3 Ph-4-0CHF2 Ph-4-0CF3 Ph-4-0CF2Br Ph-4-0CF2CHF2' Ph-4-0CF2CHFCl Ph-4-0CF2GHFCF3 Ph-4_0CF2CHF0CF3 Ph-4-0S02CH3 Ph-4-SCH3 Ph-4-S (0) CH3. Ph-4-S02CH3 Ph-4-SEt Ph-4-S02Et Ph-4_SPr-n Ph-4-S02Pr-n Ph-4-SPr-i Ph-4-S02Pr-i Ph-4-N02 Ph-4-CN Ph-4-C (0) NH2 Ph-4-C ⑸ NH2 Ph-3, 4-F2 Ph-3-F-4-C1 Ph-3,4_C12 L-46d L-47a L-47e Ph-4-Cl Ph-4-S02CH3
365 314918 200407073 3-1 2 - CH3 cf3 i_Pr H Ph-4-Cl 3-1 2-CH3 cf3 C(0) OEt H Ph-4-S02CH3 3-1 2 - CH3 cf2ci ch3 H Ph-4-Cl 3-1 2-CH3 cf2cf3 ch3 H Ph-4-S02CH3 3-1 2-CH3 Ph-4-0CF3 ch3 H Cl 3-1 2-CH3 Ph+0CF3 ch3 H ch3 3-1 2-CH3 Ph-4-0CF3 ch3 H cf3 3-1 2-CH3 Ph-4-0CF3 ch3 H OCH3 3-1 2-CH3 Ph-4-0CF3 ch3 H sch3 3-1 2 - CH3 Ph-4-0CF3 ch3 H n(ch3)2 3-1 2 - CH3+F H H H Ph-4-Cl 3-1 2-CH3-3-F H H H Ph-4-Br 3-1 2-CH3-3-F H H H Ph-4-0CF3 3-1 2-CH3-3_F H H H Ph-4-S02CH3 3-1 2 - CH 3 - 3-F cf3 H H ch3 3-1 2-CH3-5-F H H H Ph-4-Cl 3-1 2-CH3-5-F H H H Ph-4-Br 3-1 2-CH3-5-F H H H Ph-4rOCF3 3-1 2-CH3-5-F H H H Ph-4-S02CH3 3-1 2-CH3-5-F cf3 H H ch3 3-1 2-CH3+F cf3 H H Ph-4-Cl 3-1 2-CH3-5-F Ph-4-0CF3 H H ch3 3-1 2-CH3-3-CI H H H Ph-4-Cl 3-1 2-CH3-3-CI H H H Ph-4-Br 3-1 2-CH3-3-Cl H H H Ph-4-OCF3 3-1 2-CH3-3-Cl H H H Ph-4-S02CH3 3-1 2-CH3-3-CI cf3 H H ch3 3-1 2-CH3-5-C1 H H H Ph+Cl 3-1 2-CH3-5-Cl H H H Ph-4-Br 3-1 2-CH3-5-CI H H H Ph-4-0CF3 3-1 2-CH3-5-C1 H H H Ph-4-S02CH3 3-1 2-CH3-5-C1 cf3 H H ch3 3-1 2-CH3-5-CI cf3 H H Ph-4-Cl 3-1 2-CH3-5-Cl Ph+0CF3 H H ch3 3-1 2,3- (CH3) 2 H H H Ph-4-C1 3-1 2, 3- (CH3) 2 H H H Ph~4~Br 3-1 2,3- (CH3) 2 H H H Ph-4-0CF3 366 314918 200407073 3-1 2, 3- (CH3) 2 H H H Ph-4-S02CH3 3-1 2, 3- (CH3) 2 cf3 H H ch3 3-1 2,5-(CH3)2 H H H Ph-4-Cl 3-1 2, 5- (CH3) 2 H H H Ph-4-Br 3-1 2, 5-(CH3)2 H H H Ph-4-0CF3 3-1 2, 5- (CH3)2 H H H Ph-4-S02CH3 3-1 2,5-03)2 cf3 H H ch3 3-1 2, 5-(CH3) 2 cf3 H H Ph-4-C1 3-1 2, 5-(CH3)2 Ph~4~0CF 3 H H ch3 3-1 2, 6- (CH3)2 H H H Ph-4-Cl 3-1 2,6-(CH3)2 cf3 H H ch3 3-1 2-CH3-3-0CH3 H H H Ph-4-Cl' 3-1 2-CH3-3-0CH3 cf3 H H ch3 3-1 2-CH3-3-0CHF2 H H H Ph-4-Cl 3-1 2-CH3-3-0CHF2 cf3 H H ch3 3-1 2-CH3-3, 5-Cl2 H H H Ph-4-Cl 3-1 2-CH3-3, 5-Cl2 cf3 H H ch3 4-1 2-CH3 cf3 H H Ph-4-S〇2CH3 4-1 2 - CH3 Ph-4-0CF3 H H ch3 5-1 2-CH3 Ph-4-0CF3 H H ch3 6-1 2-CH3 ch3 H H Ph 6-1 2-CH3 cf3 H H ch3 6-1 2-CH3 cf3 H H C(0) OEt 6-1 2-CH3 cf3 H H Ph 6-1 2-CH3 cf3 H H Ph-4-F 6-1 2-CH3 cf3 H H Ph-4-Cl 6-1 2-CH3 cf3 H H Ph-4-SCH3 6-1 2-CH3 cf3 H H Ph-4-S02CH3 6-1 2-CH3 cf3 H H L-46d 6-1 2-CH3 Ph-4-0CF3 H H ch3 3-I-4-C1 2-CH3 cf3 H H Ph-4-Cl 4-ΠΙΙ 2-CH3 Ph-4-0CF3 H H ch3 5 - CH3 2-CH3 cf3 H H Ph-4-Cl 6 - CH3 2-CH3 Ph-4-0CF3 H H ch3 3-C1-4-CH; 3 2-CH3 cf3 H H Ph-4~F 3-C1-4-CH； 3 2-CH3 Ph~4-0CF3 H H ch3 6-Et 2-CH3 cf3 H H Ph-4-Cl 367 314918 200407073 4- CF3 6 - CF3 3-CF2CF3 3-CF2CF3 3-0CH3 6-0CH3 6-0CH3 3-CI-4-OCH3 3-0CH20-4 5- 0CHF2 6- 0CHF2 5- 0CF3 3-0CF20-4 3-OCF2〇-4 3-0CF20-4 3-0CF20-4 3-0CF20-4 3-0CF2CF20-4 3-0CF2CF20-4 6- SCH3 6-S02CH3 6-SPr-i 6-S (O)Pr-I 6-S02Pr-I 6-S (0) CF3 3-SCH2CF3 3-SCH2CF3 6-SCH2CF3 3-S(0)CH2CF3 6-S(0)CH2CF3 3-S02CH2CF3 3-CI-6-SCF3 6-N〇2 6 - N02 6-NO 2 6-NO 2 6-NO 2 2 - CH3 2 - CH3 2 - CH3 2-CH3 2-CH3 2 - CH3 2 - CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2 - CH3 2 - CH3 2-CH3 2-CH3 2-CH3 2 - CH3 2-CH3 2-CH3 2 - CH3 2 - CH3 2 - CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2 - CH3 2 - CH3 2 - CH3 2 - CH3 2 - CH3 2 - CH3
Ph-4-OCF c cf3 cf3 Ph-4-OCF: CF3 cf3 Ph-4-0CF, Ph-4-0CF, Ph-4-〇CF2 Ph-4~0CFc cf3 Ph-4-0CF, cf3 cf3 cf3 cf3 Ph-4-OCF3 CF3 Ph-4-0CF2 cf3 Ph-4-OCF, cf3 Ph-4-0CF2 cf3 Ph-4-0CF, CF3 Ph-4-0CF2 CF3 cf3 Ph-4-0CF3 Ph-4-0CF3 cf3 cf3 cf3 cf3 cf3 CF, CH3 Ph-4-Cl Ph-4-Cl CH3 Ph-4-Cl Ph~4~F CH3 ch3 ch3 ch3 H Ph-4-Cl CH3 . Ph-4-Cl Ph~4*~Br Ph-4-0CF3 Ph-4-S02CH3 CH3 Ph-4-E ch3 Ph-4-C1 CH3 Ph-4-Cl CH3 Ph-4-Cl CH3 Ph-4-Cl CH3 Ph-4-Cl Ph-4-Cl CH3 ch3 Ph_4-Cl Ph~4~F Ph-4-Cl Ph-4_Br Ph-4-0CF3 Ph_4-S02CH3
368 314918 200407073 6_N02 6-NO 2 6-N02 6 - N02 3-NH2 3-NH2 3-NHCH3 3-NHEt-4-F 3-_+F 3-NHEt-6-F 3-NHPr-n 3-NHPr-i 3-NHBu-n 3-NHBu-i 3-NHBu-s 3-NHCH20CH3 3_NHCH20Et 3-NHCH (CH3)〇CH3 3 - NHCH(Et)0CH3 3-NHCHO 3-NHC (0) CH3 3-NHC (0)Et 3-NHC (0) Pr-n 3-NHC (O)Pr-i 3-NHC (0) Pr-c 3-NHC (O)Bu-t 3-NHC (0) CHF2 3-NHC (0) CF3 3-NHC (0) CF2C1 3-NHC (0) Ph 3-NHC (0) OCH3 3-NHC (0) OEt 3-NHC (0) OPr-n 3-NHC (0) OPr-i 3-NHC (0) 0CH2CH2C1 3-NHC (0) OCH2CF3 3-N(CHs) 2 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2 - CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2 - CH3 2 - CH3 2-CH3 2-CH3 2-CH3 2 - CH3 2-CH3 2 - CH3 2-CH3 2-CH3 2 - CH3 2 - CH3 2-CH3 2-CH3 2-CH3 2-CH3 2 - CH3 2-CH3 2-CH3 2-CH3 2-CH3
Ph-4-F Ph-4-Cl
Ph-4-Br Ph-4-OCF3 cf3 Ph-4-0CF3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3 cf3
H H
ch3 ch3 ch3 ch3 Ph-4-C] ch3 Ph-4-F Ph-4-Cl Ph-4-S02CH3 L - 46d Ph-4-F Ph-4-Cl' Ph_4_S〇2CH3 L-46d Ph-4-F Ph-4-C1 Ph-4-S02CH3 L-46d . Ph-4-F Ph-4-C1 Ph-4-S02CH3 L - 46d Ph-4-F Ph-4-Cl Ph-4-S02CH3 L-46d Ph-4-F Ph-4-Cl Ph-4~S02CH3 L - 46d Ph-4-F Ph-4-Cl Ph+S02CH3 L - 46d Ph-4-F Ph-4-Cl Ph-4-S02CH3
369 314918 200407073 3-N(CH3)Et-4-F 2-CH3 cf3 3-N (CH3)Et-5-F 2-CH3 cf3 3-N (CH3)Et-6-F 2-CH3 cf3 3-N (CH3)Pr-n 2-CH3 cf3 3-N(CH3)Pr - i 2 - CH3 cf3 3-N (CH3)Bu-n 2 - CH3 cf3 3-N(CH3)Bu - i 2-CH3 cf3 3-N(CH3)Bu - s 2 - CH3 cf3 3-N(CH3)CH0 2-CH3 cf3 3-N(CH3)C(0)CH3 2 - CH3 cf3 3-N (CH3)C(0)Et 2 - CH3 cf3 3-N (CH3)C(0)Pr-n 2 - CH3 cf3 3-N (CH3)C(0)Pr-i 2-CH3 cf3 3-N (CH3)C(0)Pr-c 2-CH3 cf3 3-N (CH3)C(0)Bu-t 2-CH3 cf3 3-N (CH3)C(0) CF3 hh3 cf3 3-N (CH3)C(0) CF2C1 2-CH3 cf3 3-N(CH3)C(0)Ph 2-CH3 cf3 3-N(CH3)C(0)0CH3 2 - CH3 cf3 3-N (CH3)C(0) OEt 2-CH3 cf3 3-N (Et) 2 2-CH3 cf3 3-N(Et)CHO 2-CH3 cf3 3-N (Et)C(O) CH3-4-F 2-CH3 cf3 3-N(Et)C(0) CH3-5-F 2 - CH3 cf3 3-N (Et)C(O) CH3-6-F 2 - CH3 cf3 3-N (Et)C(0)Et 2-CH3 cf3 3-N (Et)C(0)Pr-n 2-CH3 cf3 3-N (EOC(O)Pr-i 2 - CH3 cf3 3-N(Et)C(0)Pr_c 2-CH3 cf3 3-N(Et)C(0)Bu-t 2 - CH3 cf3 3-N(Et)C(0) CF3 2 - CH3 cf3 3-N(Et)C(0) CF2C1 2-CH3 cf3 3-N(Et)C(0)Ph 2 - CH3 cf3 3-N (Et)C(O) OCH3 2 - CH3 cf3 3-N(Et)C(0) OEt 2-CH3 cf3 3-N(Pr-n)CHO 2-CH3 cf3 3-N(Pr-n)C(0)CH3 2-CH3 cf3
L-46d
Ph-4-F
Ph-4-Cl
Ph+S02CH3 L-46d
Ph**4 - F
Ph-4-Cl
Ph_4-S02CH3 L-46d
Ph~4~F
Ph-4-Cl
Ph-4-S02CH3 L-46d
Ph-4-F
Ph-4-C1
Ph-4-S02CH3 L-46d
Ph - 4-F·
Ph-4-C1 Ph-4-S02CH3 L - 46d Ph-4_F Ph-4-Cl Ph-4-S02CH3 L-46d Ph-4-F Ph-4-Cl Ph-4-S02CH3 L-46d Ph~4~F Ph-4-Cl Ph-4-S02CH3 L-46d Ph-4*-F Ph-4-C1 Ph-4-S02CH3 L-46d 370 314918 200407073
3-N(Pr - n)C(0)CF3 3-N (Pr-n)C(O) OCH3 3-N(Pr-n)C(0)0Et 3-N(Pr - i)CH〇 3 -N(Pr_i)C(0)CH3 3-N (Pr-i)C(O) CF3 3-N(Pr - i)C(0)0CH3 3-N (Pr-i)C(O) OEt 3-N=CH0CH3 3-N=CH0Et 3-N=CHOPr-n 3-N=C (CH3)〇CH3 3 - N=C(CH3)OEt 3-N=C (Et)OCH3 3 - N=C(Et)OEt 3-N=C (Pr-n) 0CH3 3-N=C (Pr~n) OEt 3-N=C (Bu-n) OCH3 3-N=C (Bu-n) OEt 3-N=C (Ph) OEt 3 - CN 3 - CN 3 - CN 3-CN 3 - CN
3-C(0) NHPr-i 3-C三CH 3-CECSi(CH3)3
6-CeCH 6-Ph 3-CH=CH-CH=CH-4 3-Si (CH3) 3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2-CH3 2 - CH3 2 - CH3 2-CH3 2 - CH3 2 - CH3 2 - CH3 2-CH3 2 - CH3 2 - CH3 2-CH3 2 - CH3 2-CH3 2 - CH3 2-CH3 2-CH3 2 - CH3 2-CH3 2-CH3 2 - CH3 2 - CH3 cf3 H H Ph_4-F cf3 H H Ph-4-Cl cf3 H H Ph-4-S02CH cf3 H H L - 46d cf3 H H Ph-4-F cf3 H H Ph+Cl cf3 H H Ph+S02CH cf3 H H L-46d cf3 H H Ph-4~F cf3 H H Ph-4-Cl cf3 H H Ph-4-S02CH cf3 H H L-46d cf3 H H Ph-4-F cf3 H H Ph-4-Cl cf3 H H Ph-4-S02CH cf3 H H L_46d cf3 H H Ph-4-F cf3 H H Ph-4-Cl cf3 H H Ph-4-S02CH cf3 H H L - 46d cf3 H H Ph+Cl cf3 H H Ph+Br cf3 H H Ph-4-0CF3 cf3 H H Ph-4-S02CH； Ph-4-0CF3 H H ch3 cf3 H H Ph-4-Cl cf3 H H Ph-4-Cl cf3 H H Ph_4-Cl cf3 H H Ph-4-Cl Ph-4-0CF3 H H ch3 cf3 H H Ph-4-Cl cf3 H H Ph+Cl
371 314918 200407073 第4表
[3]-1
[3]-3 R5
372 314918 200407073
[3]-7
[3]-9 [3]· 8
[3]-11 [3] - 12
373 314918 200407073
[3] - 13
[3] -15
[3] - 16 5Rcl5RC1
[3]-is [3】-17 374 314918 200407073
-N FOR3 [33-19
[3】-20
[3] - 24 375 314918 200407073
[3]-25
[3] - 26
[3]-27
[3] -28
R2 -N ch3so2 δ R3 [3]-29
[3] - 30 376 314918 200407073
[3] -33 [3] - 34 R4 R5
[3]-35
[3] - 36 或 377 314918 200407073 R2 R3 Y R4 R5 Η ch3 ch3 cf3 Ph~4~F Η ch3 ch3 cf3 Ph-4-Cl Η ch3 ch3 cf3 Ph_4_Br Η ch3 ch3 cf3 Ph-4-CF3 Η ch3 ch3 cf3 Ph-4-0CF3 Η ch3 ch3 cf3 Ph-4_S02CH3 Η ch3 ch3 cf3 P1HKN Η ch3 ch3 cf3 Ph-3, 4-Cl2 Η ch3 ch3 cf3 L - 46d Η ch3 ch3 Ph-4-F H Η ch3 ch3 Ph-4-C1 H Η ch3 ch3 Ph-4-Br H Η ch3 ch3 Ph-4-CF3 H Η ch3 ch3 Ph_4-0CHF2 H Η CH3 ch3 Ph-4-0CF3 H Η ch3 ch3 Ph-4-0 (L-45g) H Η ch3 ch3 Ph-3,4-Cl2 H Η ch3 ch3 L - 46d H ch3 ch3 ch3 cf3 Ph-4-SCH3 ch3 ch3 ch3 cf3 Ph-4-S02CH3 ch3 ch3 ch3 Ph-4-F H ch3 ch3 ch3 Ph-4-Cl H Η Et ch3 ch3 Ph-4-C1 Η Et ch3 Et Ph-4-S02CH3 Η Et ch3 chf2 Ph-4-Cl Η Et ch3 CF3 Ph-4-F Η Et ch3 cf3 Ph+Cl Η Et ch3 cf3 Ph-4-Br Η Et ch3 cf3 Ph-4-I Η Et ch3 cf3 Ph-4-CF3 Η Et ch3 cf3 Ph-4-0CHF2 Η Et ch3 cf3 Ph-4-0CF3 Η Et ch3 cf3 Ph-4-0S02CH Η Et ch3 cf3 Ph-4-SCH3
378 314918 200407073
Η Et ch3 cf3 Ph-4-S (0) CH: Η Et ch3 cf3 Ph-4~S02CH3 Η Et ch3 cf3 Ph-4-CN Η Et ch3 cf3 Ph-4-C (0) NH； Η Et ch3 cf3 Ph - 4-C ⑸ NH: Η Et ch3 CFs Ph-3, 4-F2 Η Et ch3 cf3 Ph~3_F~4_Cl Η Et ch3 cf3 Ph_3, 4_C12 Η Et ch3 cf3 L-45d Η Et ch3 cf3 L-45g Η Et ch3 cf3 L-46d Η Et ch3 cf3 L - 46g Η Et ch3 cf3 L - 47a Η Et ch3 cf3 L - 47e Η Et ch3 cf2ci Ph-4-S02CH3 Η Et ch3 cf2cf3 Ph-4-Cl Η Et ch3 Ph-4~F H Η Et ch3 Ph-4-Cl H Η Et ch3 Ph-4-Br H Η Et ch3 Ph-4-I H Η Et ch3 Ph-4-CF3 H Η Et ch3 Ph-4_0CHF2 H Η Et ch3 Ph-4-0CF3 H Η Et ch3 Ph-4-0CF2Br H Η Et ch3 Ph-4-0CF2CHF2 H Η Et ch3 Ph-4-0CF2CHFCl H Η Et ch3 Ph-4-0CF2CHFCF3 H Η Et ch3 Ph-4-0CF2CHF0CF3 H Η Et ch3 Ph-4-0 (L-45g) H Η Et ch3 Ph-4-SCF3 H Η Et ch3 Ph-4-CN H Η Et ch3 Ph-3, 4-F2 H Η Et ch3 Ph-3-F-4-C1 H Η Et ch3 Ph-3, 4-CI2 H Η Et ch3 L-45d H Η Et ch3 L - 45e H Η Et ch3 L-45g H
379 314918 200407073
Η Et ch3 L-45m H Η Et ch3 L - 46d H Η Et ch3 L-46e H Η Et ch3 L - 46g H Η Et ch3 L-46j H Η Et ch3 L-46k H Η Et ch3 L-46r H Η Et ch3 L-47a H Η Et ch3 L - 47e H Et Et ch3 cf3 Ph-4-F Et Et ch3 cf3 Ph-4-Cl Et Et ch3 cf3 Ph-4-0S02CH3 Et Et ch3 cf3 Ph-4-SCH3 Et Et ch3 cf3 Ph+S(0)CH3 Et Et ch3 cf3 Ph-4-S02CH3 Et Et ch3 cf3 Ph+CN Et Et ch3 cf3 L - 46d Et Et ch3 Ph-4-F H Et Et ch3 Ph-4-Cl H Et Et ch3 Ph-4-Br H H n-Pr ch3 cf3 Ph-4-F H n - Pr ch3 cf3 Ph+Cl H n-Pr ch3 cf3 Ph-4-0S02CH3 H n-Pr ch3 cf3 Ph-4-SCH3 H n-Pr ch3 CF3 Ph-4 - S(0)CH3 H n - Pr ch3 cf3 Ph-4-S02CH3 H n-Pr ch3 cf3 Ph-4-CN H n-Pr ch3 cf3 L-46d H n-Pr ch3 Ph-4-F H H n-Pr ch3 Ph+Cl H H n-Pr ch3 Ph-4~Br H H n-Pr ch3 Ph-4-CF3 H H n-Pr ch3 Ph-4-0CHF2 H H n-Pr ch3 P1HK)CF3 H H n-Pr ch3 Ph-4-0 (L-45g) H H n-Pr ch3 Ph-4-SCF3 H H n-Pr ch3 Ph-4-CN H 380 314918 200407073 Η Η Η n - Pr ch3 Ph-3, 4-F2 H n-Pr ch3 Ph-3-F-4-Cl H n-Pr ch3 Ph-3, 4-Cl2 H η-Pr ch3 L-46d H i - Pr Cl cf3 Ph-4-F i - Pr Cl cf3 Ph-4-C1 i - Pr Cl cf3 Ph-4-0S02CH3 i-Pr Cl cf3 Ph-4-SCH3 i - Pr Cl cf3 Ph-4_S02CH3 i-Pr Cl cf3 Ph-4-CN i - Pr Cl cf3 Ph-4-C (0) NH2 i-Pr Cl cf3 L-46d i-Pr Cl Ph-4-F H i-Pr Cl Ph+Cl H i-Pr Cl Ph-4-Br H i-Pr Cl Ph-4-CF3 H i-Pr Cl Ph-4-0CHF2 H i-Pr Cl Ph-4-0CF3 H i-Pr Cl Ph - 4-0 (L-45g) H i-Pr Cl Ph-4-CN H i-Pr Cl L - 46d ch3 i-Pr ch3 F Ph-4-F i-Pr ch3 F Ph-4-Cl i-Pr ch3 F Ph-4-Br i-Pr ch3 F Ph~4~CF 3 i-Pr ch3 F Ph-4-0CF3 i_Pr ch3 F Ph-4-SCH3 i-Pr ch3 F Ph+S (0) CH3 i-Pr ch3 F Ph-4-S02CH3 i-Pr ch3 F Ph-4-CN i-Pr ch3 F Ph-3, 4-Cl2 i-Pr ch3 Cl Ph-4-F i-Pr ch3 Cl Ph-4-Cl i-Pr ch3 Cl Ph-4-Br i-Pr ch3 Cl Ph-4-CF3 i-Pr ch3 Cl Ph-4-0CHF2 i-Pr ch3 Cl Ph-4-0CF3
381 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
Cl Ph-4_0S02CH3
Cl Ph-4-SCH3
Cl Ph-4-S (0) CH3
Cl Ph-4-S02CH3
Cl Ph-4-CN
Cl Ph-4-C (0) NH2
Cl Ph-4-C (S) NH2
Cl Ph-3,4-F2
Cl Ph-3_F_4-Cl
Cl Ph~3,4-Cl2
Cl L_45d
Cl L-45e
Cl L-45f
Cl L_45g
Cl L-45h
Cl L_45m
Cl L-46d
Cl L-46e
Cl L-46f
Cl L-46g
Cl L-46h
Cl L-46i
Cl L-46j
Cl L-46k
Cl L-46m
Cl L-46n
Cl L-46o
Cl L-46p
Cl L-46q
Cl L-46r
Cl L^47a
Cl L-47e
Br Ph-4-F
Br Ph-4~C1
Br Ph-4-Br
Br Ph-4_CF3
Br Ph-4-0CHF2
382 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
Br Ph-4-0CF3 Br Ph-4-0S02CH3 Br Ph-4-SCH3 Br Ph-4-S (0) CH3 Br Ph-4*S02CH3 Br Ph-4-CN Br Ph~4-C (0) NH2 Br Ph-4-C(S)NH2 Br Ph-3, 4-F2 Br Ph-3-F-4-C1 Br Ph-3,‘C12 Br L-46d ch3 Ph~4~F ch3 Ph-4-Cl ch3 Ph-4-Br ch3 Ph-4-CF3 ch3 Ph-4-0CHF2 ch3 Ph-4-0CF3 ch3 Ph-4-SCH3 ch3 Ph+S (0) CH3 ch3 Ph-4-S02CH3 ch3 Ph-4-CN ch3 Ph-4-C (0) NH2 ch3 Ph - 4-C ⑸ NH2 Et Ph-4-F Et Ph-4-Cl Et Ph-4-S02CH3 n-Pr Ph-4-Cl i-Pr Ph-4-C1 c - Pr H c - Pr Ph+Cl n-Bu Ph-4-Cl s-Bu Ph-4-C1 i-Bu Ph-4-Cl c-Bu H c - Bu Ph+Cl n-Pen Ph+Cl
383 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
c-Pen H c-Pen Ph-4-C1 n-Hex Ph-4-Cl c-Hex H c-Hex Ph-4-Cl CH2F Ph-4-Cl ch2f Ph-4-S02CH3 ch2ci Ph-4-Cl ch2ci Ph-4-S02CH3 CH2Br Ph-4-Cl CH2Br Ph-4-S〇2CH3 chf2 Ph_4-F chf2 Ph-4-Cl chf2 Ph-4_0CHF2 chf2 Ph-4-0S02CH3 chf2 Ph-4-SCH3 chf2 Ph-4-S (0) CH3 chf2 Ph-4-S02CH3 chf2 Ph+CN chf2 Ph-4-C (0) NH2 chf2 Ph-4-C (S) NH2 cf3 Ph-4-F cf3 Ph-4-Cl cf3 Ph-4-0CHF2 cf3 Ph-4-0S02CH3 cf3 Ph-4-SCH3 cf3 Ph-4-S (0) CH3 cf3 Ph+S02CH3 cf3 Ph-4-SEt cf3 Ph-4-S (0)Et cf3 Ph+S02Et cf3 PIH-SPr-n cf3 Ph-4-S (O)Pr-n cf3 Ph-4-S02Pr-n cf3 Ph-4-SPr-i cf3 Ph - 4-S(0)Pr - i cf3 Ph-4-S02Pr-i 384 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 CF3 Ph-4-SBu-n CF3 Ph-4-S (0) Bu-n CF 3 Ph~4_S〇2Bu~n CF3 Ph-4-SBu-t CF3 Ph-4-S (O)Bu-t CF3 Ph-4-S02Bu-t
CF3 Ph-4-SCH2F
CF3 Ph-4-S(0)CH2F
CF3 Ph-4-S02CH2F CF3 Ph-4-SCHF2 CF3 Ph-4-S (0) CHF2 CF3 Ph-4-S02CHF2 CF3 Ph-4-SCF3 CF3 Ph-4-S (0) CF3 CF3 Ph-4-S02CF3 CF3 Ph-4-SCF2Cl CF3 Ph-4-S (0) CF2C1 CF3 Ph-4-S02CF2Cl CF3 Ph-4-SCF2Br CF3 Ph-4-S (0) CF2Br CF3 Ph-4-S02CF2Br CF3 Ph-4-N02
CF3 Ph-4-CN CF3 Ph-4-C (0) NH2 CF3 Ph-4-C (S) NH2 CF3 Ph-3,4-F2 CF3 Ph-3-F-4-C1 CF3 Ph-3,4-Cl2 CF3 L-45a CF 3 L-45c CF3 L-45d CF3 L-45e CF3 L-45g CF3 L-45m CF3 L-46a CF3 L-46c CF3 L-46d
385 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
cf3 L - 46e cf3 L-46g cf3 L-46j cf3 L-46k cf3 L-46q cf3 L-46r cf3 L-47a cf3 L-47e cf2ci Ph_4&quot;F cf2ci Ph-4-Cl cf2ci Ph-4-0CHF2 cf2ci Ph-4-0S02CH cf2ci Ph-4-SCH3 cf2ci Ph-4-S (0) CH； cf2ci Ph-4-S02CH3 cf2ci Ph+CN cf2ci Ph-4_C (0) NH: cf2ci Ph - 4_(MS)NH: CF2Br Ph-4-F CF2Br Ph-4-C1 CF2Br Ph-4-S02CH3 CF2CHF2 Ph-4-Cl cf2chf2 Ph-4-S02CH3 cf2cf3 Ph~4~F cf2cf3 Ph-4-Cl cf2cf3 Ph-4-S02CH3 cf2cf2ci Ph-4-Cl cf2cf2ci Ph-4-S02CH3 CF2CF2Br Ph-4-Cl CF2CF2Br Ph-4-S02CH3 CFCICF3 Ph+Cl CFCICF3 Ph-4_S02CH3 CFBrCFa Ph-4-Cl CFBrCF3 Ph-4-S02CH3 CFC1CF2C1 Ph-4-Cl cfcicf2ci Ph-4~S02CH3 cf2cf2cf3 Ph-4-Cl 386 314918 200407073 i-Pr ch3 cf2cf2cf3 Ph-4-S02CH3 i-Pr ch3 CF (CF3) 2 Ph-4-Cl i-Pr ch3 CF (CF3)2 Ph-4-S02CH3 i-Pr ch3 cf2cf2cf2cf3 Ph-4-C1 i-Pr ch3 cf2cf2cf2cf3 Ph-4-S02CH3 i-Pr ch3 ch2och3 H i-Pr ch3 ch2och3 Ph-4-Cl i-Pr ch3 ch2och3 Ph-4-S02CH3 i-Pr ch3 CH20Et H i-Pr ch3 CH20Et Ph+Cl i-Pr ch3 CH20Et Ph-4-S02CH3 i-Pr ch3 ch2och2cf3 H i-Pr ch3 ch2och2cf3 ch3 i-Pr ch3 ch2och2cf3 Et i-Pr ch3 ch2och2cf3 n-Pr i-Pr ch3 ch2och2cf3 i-Pr i-Pr ch3 ch2och2cf3 Ph-4-F i-Pr ch3 ch2och2cf3 Ph-4-Cl i-Pr ch3 ch2och2cf3 Ph-4-S02CH3 i-Pr ch3 ch2och2cf2cf3 H i-Pr ch3 ch2och2cf2cf3 ch3 i-Pr ch3 ch2och2cf2cf3 Et i-Pr ch3 ch2och2cf2cf3 n-Pr i-Pr ch3 ch2och2cf2cf3 i-Pr i-Pr ch3 ch2och2cf2cf3 Ph-4-F i-Pr ch3 ch2och2cf2cf3 Ph-4-C1 i-Pr ch3 ch2och2cf2cf3 Ph-4-S02CH3 i，Pr ch3 cf2ocf2cf2ocf3 H i-Pr ch3 CF (CF3)〇CF2CF2CF3 H i-Pr ch3 ch2sch3 H i-Pr ch3 ch2sch3 Ph+F i-Pr ch3 ch2sch3 Ph+Cl i-Pr ch3 ch2sch3 Ph-4-Br i - Pr ch3 ch2sch3 Ph-4-CF3 i-Pr ch3 ch2sch3 Ph-4-0CHF2 i-Pr ch3 ch2sch3 Ph-4-0CF3 i-Pr ch3 ch2sch3 Ph+S02CH3 387
314918 200407073
Η i-Pr ch3 ch2sch3 Ph-3, 4-Cl2 Η i-Pr ch3 ch2so2ch3 H Η i-Pr ch3 ch2so2ch3 Ph-4-F Η i - Pr ch3 ch2so2ch3 Ph-4-Cl Η i-Pr ch3 ch2so2ch3 Ph-4-S02CH Η i-Pr ch3 CH2SEt H Η i-Pr ch3 CH2SEt Ph-4-Cl Η i-Pr ch3 CH2SEt Ph-4-S02CH Η i-Pr ch3 ch2scf3 H Η i-Pr ch3 ch2scf3 Ph-4-F Η i-Pr ch3 ch2scf3 Ph-4-Cl Η i-Pr ch3 ch2scf3 Ph-4-S02CH Η i-Pr ch3 och3 H Η i-Pr ch3 so2cf3 H Η i-Pr ch3 SPh H Η 卜Pr ch3 T-22 H Η i-Pr ch3 T - 23 H Η i-Pr ch3 T-24 H Η i-Pr ch3 Ph H Η i-Pr ch3 Ph+F H Η i-Pr ch3 Ph-2-Cl H Η i-Pr ch3 Ph-3-Cl H Η i-Pr ch3 Ph-4-C1 H Η i-Pr ch3 Ph_4~Br H Η i-Pr ch3 Ph-4-I H Η i-Pr ch3 Ph+CF3 H Η i-Pr ch3 Ph-4-CH20CH2CF3 H Η i-Pr ch3 Ph-4-C (CF3) 2〇H H Η i-Pr ch3 Ph+CH2SCH3 H Η i-Pr ch3 Ph-4 - CH2S(0)CH3 H Η i-Pr ch3 Ph-4-CH2S02CH3 H Η i-Pr ch3 Ph-4-CH2SEt H Η i-Pr ch3 PlHKH2S(0)Et H Η i-Pr ch3 Ph~4~CH2S02Et H Η i-Pr ch3 Ph-4-CH2SPr-n H Η i-Pr ch3 Ph-4-CH2S02Pr-n H Η i-Pr ch3 Ph-4-CH2SPr-i H
388 314918 200407073 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H i-Pr ch3 H 卜Pr ch3 H i-Pr ch3
Ph-4-CH2S02Pr-i Η
Ph-4-CH2SPr-c Η
Ph-4-CH2S02Pr-c Η
Ph-4-CH2SBu_n H
Ph-4-CH2S02Bu-η H
Ph-4-CH2SCF3 H
Ph-4-CH2S(0)CF3 H
Ph-4_CH2S02CF3 H
Ph-4-CH2SCH2CF3 H
Ph-4-0CHF2 H
Ph-4-0CF3 H
Ph-4-0S02CH3 H
Ph-4-0S02Et H
Ph-4-0S02Pr_n H
Ph»4-0S02Pr-i H
Ph-4-0S02Pr-c H
Ph-4-0S02Bu-n H
Ph-4-0S02CHCl2 H
Ph-4-0S02CF3 H
Ph-4-0S02CH2CF3 H
Ph-4-SCH3 H
Ph-4 - S(0)CH3 H
Ph-4-S02CH3 H
Ph-4-SEt H
Ph - 4-S(0)Et H
Ph-4-S02Et H
Ph-4-SPr-η H
Ph-4-S (0) Pr-η H
Ph-4-S02Pr-n H
Ph-4-SPr-i H
Ph-4-S (O)Pr-i H
Ph-4-S02Pr-i H
Ph-4~SBu~n H
Ph - 4-S (0) Bu-n H
Ph-4-S02Bu-n H
Ph-4_SBu_t H
Ph-4-S (O)Bu-t H
389 314918 200407073 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H 卜Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3 H i-Pr CH3
Ph - 4**S02Bu-t H
Ph-4-SCH2F H
Ph-4-S (0) CH2F H
Ph-4-S02CH2F H
Ph-4-SCHF2 H
Ph-4-S (0) CHF2 H
Ph-4-S02CHF2 H
Ph~4-SCF3 H
Ph-4 - S(0)CF3 H
Ph-4-S02CF3 H
Ph-4-SCF2Cl H
Ph-4 - S(0)CF2C1 H
Ph-4-S02CF2Cl H
Ph-4-SCF2Br H
Ph-4-S (0) CF2Br H
Ph-4-S02CF2Br H
Ph-4-N02 H
Ph-4-N (CH3)2 H
Ph-4-CN H
Ph - 4-C(0)NH2 H
Ph - 4-C(0)NHCH3 H
Ph-4-C (0) NHEt H
Ph-4-C (0)N(CH3) 2 H
Ph-4-C (S) NH2 H
Ph-3,4-F2 H
Ph-3-F-4-C1 H
Ph-3,4-Cl2 H
L-lb H
L - lc H
L-ld H
L - le H
L-li H
L-lg H
L - lh H
L-li H
L-2b H
L~3b H
390 314918 200407073 i - Pr ch3 L-3c H i - Pr ch3 L - 3d H 卜Pr ch3 L-3g H i-Pr ch3 L - 3h H i - Pr ch3 L - 3i H i-Pr ch3 L-3j H i-Pr ch3 L-3k H i-Pr ch3 L - 31 H i-Pr ch3 L-3ni H i-Pr ch3 L_3n H i-Pr ch3 L - 4b H i-Pr ch3 L-4c H i-Pr ch3 L-4d H i-Pr ch3 L - 4e H i-Pr ch3 L - 10b H i-Pr ch3 L-10c H i-Pr ch3 L - lOd H i-Pr ch3 L - 16a H i-Pr ch3 L - 16b H i-Pr ch3 L - 21b H i-Pr ch3 L-21c H i-Pr ch3 L-21d H i-Pr ch3 L-21e H i-Pr ch3 L - 21i H i-Pr ch3 L-22b H i-Pr ch3 L-22c H i-Pr ch3 L-22d H i-Pr ch3 L-23b H i-Pr ch3 L - 23c H i-Pr ch3 L-23d H i-Pr ch3 L-23e H i-Pr ch3 L-30a H i-Pr ch3 L-31a H i-Pr ch3 L-31b H i-Pr ch3 L-3 lc H i-Pr ch3 L-45a H i-Pr ch3 L - 45c H 391 314918 200407073
i-Pr ch3 L_45d H i-Pr ch3 L_45e H i - Pr ch3 L - 45i H i-Pr ch3 L - 45g H i-Pr ch3 L-45h H i-Pr ch3 L-451 H i-Pr ch3 L - 45m H i-Pr ch3 L-46a H i-Pr ch3 L-46c H i-Pr ch3 L-46d H i-Pr ch3 L - 46e H i-Pr ch3 L - 46i H i-Pr ch3 L - 46g H i-Pr ch3 L-46h H i - Pr ch3 L - 46i H i-Pr ch3 L-46j H i-Pr ch3 L - 46k H i-Pr ch3 L-461 H i-Pr ch3 L-46m H i-Pr ch3 L - 46n H i-Pr ch3 L - 46o H i-Pr ch3 L-46p H i-Pr ch3 L-46q H i-Pr ch3 L-46r H i-Pr ch3 L-47a H i-Pr ch3 L - 47e H i-Pr ch3 L - 50b H i-Pr ch3 L-50c H i-Pr ch3 L-50d H i-Pr ch3 L - 50e H i-Pr ch3 L - 50i H i-Pr ch3 L - 51b H i-Pr ch3 L-51c H I3 i-Pr ch3 cf3 Ph-4-S02CH I3 i-Pr ch3 Ph-4-Cl H i-Pr Et Ph-4-Cl H i-Pr ch2oh Ph-4-C1 H 392 314918 200407073 Η 卜Ργ och3 Ph-4-C1 H Η i-Pr sch3 Ph+Cl H Η c-Pr ch3 cf3 Ph~4~F Η c-Pr ch3 cf3 Ph-4-C1 Η c-Pr ch3 cf3 Ph-4-0S02CH3 Η c-Pr ch3 cf3 Ph+SCH3 Η c-Pr ch3 cf3 Ph+S(0)CH3 Η c-Pr ch3 cf3 Ph-4-S02CH3 Η c-Pr ch3 cf3 Ph-4-CN Η c-Pr ch3 cf3 Ph-3, 4-Cl2 Η c-Pr ch3 cf3 L - 46d Η c-Pr ch3 Ph-4-F H Η c-Pr ch3 Ph-4-Cl H Η c-Pr ch3 Ph-4-Br H Η c-Pr ch3 Ph-4-CF3 H Η c-Pr ch3 Ph-4-0CF3 H Η c-Pr ch3 Ph-4 - 0 (L-45g) H Η cHPr ch3 Ph-4-CN H Η c-Pr ch3 Ph-3, 4-Cl2 H Η n-Bu ch3 cf3 Ph-4~F Η n - Bu ch3 cf3 Ph-4-Cl Η n-Bu ch3 cf3 Ph-4-OS02CH3 Η n-Bu ch3 cf3 Ph-4-SCH3 Η n - Bu ch3 cf3 Ph-4-S (0) CH3 Η n-Bu ch3 cf3 Ph-4_S02CH3 Η n-Bu ch3 cf3 Ph-4-CN Η n-Bu ch3 cf3 L-46d Η n-Bu ch3 Ph-4-F H Η n-Bu ch3 Ph-4-C1 H Η n-Bu ch3 Ph-4_Br H Η i - Bu ch3 cf3 Ph-4-S02CH3 Η i - Bu ch3 Ph-4-Cl H Η s-Bu ch3 cf3 Ph-4-F Η s-Bu ch3 CF3 Ph-4-Cl Η s-Bu ch3 cf3 Ph-4-0CHF2 Η s-Bu ch3 cf3 Ph-4_0S02CH3 Η s-Bu ch3 cf3 Ph-4-SCH3
393 314918 200407073 Η s - Bu ch3 cf3 Ph-4-S (0) CH3 Η s-Bu ch3 cf3 Ph-4-S02CH3 Η s - Bu ch3 cf3 Ph~4~SEt Η s-Bu ch3 cf3 Ph+S(0)Et Η s-Bu ch3 cf3 Ph-4-S02Et Η s-Bu ch3 cf3 Ph-4-SPr-n Η s-Bu ch3 cf3 Ph-4_S(0)Pr-n Η s-Bu ch3 cf3 Ph-4-S02Pr-n Η s-Bu ch3 cf3 Ph-4-SPr-i Η s-Bu ch3 CFa Ph-4-S(0)Pr-i Η s - Bu ch3 CF3 Ph-4-S02Pr-i Η s-Bu ch3 cf3 Ph-4-SCHF2 Η s-Bu ch3 cf3 Ph-4-S (0) CHF2 Η s-Bu ch3 cf3 Ph-4-S02CHF2 Η s-Bu ch3 cf3 Ph-4-SCF3 Η s-Bu ch3 cf3 Ph-4-S (0) CF3 Η s-Bu ch3 cf3 Ph-4-S02CF3 Η s-Bu ch3 cf3 Ph-4-SCF2Cl Η s-Bu ch3 cf3 Ph-4-S (0) CF2C1 Η s-Bu ch3 cf3 PtHhS02CF2Cl Η s-Bu ch3 cf3 Ph-4-SCF2Br Η s-Bu ch3 cf3 Ph+S(0)CF2Br Η s-Bu ch3 cf3 Ph-4-S02CF2Br Η s-Bu ch3 cf3 Ph_4-CN Η s-Bu ch3 cf3 Ph-4-C (0) NH2 Η s-Bu ch3 cf3 Ph-4-C(S)NH2 Η s-Bu ch3 cf3 Ph~3, 4_F2 Η s-Bu .ch3 CF3 Ph_3-F-4-C1 Η s-Bu ch3 cf3 Ph-3, 4-Cl2 Η s-Bu ch3 cf3 L - 45c Η s-Bu ch3 cf3 L-45d Η s-Bu ch3 cf3 L - 45e Η s-Bu ch3 cf3 L-45g Η s-Bu ch3 CFa L - 45m Η s-Bu ch3 CF3 L-46c Η s-Bu ch3 cf3 L-46d Η s-Bu ch3 cf3 L - 46e
394 314918 200407073 CH3 cf3 CH3 Ph-4-F CH3 Ph-4-C1 CH3 Ph-4-Br CH3 Ph-4-CF3 CH3 Ph-4-0CHF2 CH3 Ph-4-0CF3 CH3 Ph-4-0 (L-45g) CH3 Ph_4_SCF3 CH3 Ph-4-N02 CH3 Ph-4-CN CH3 Ph-4-C (0) NH2 CH3 Ph-4-C (S) NH2 CH3 Ph-3,4-F2 CH3 Ph-3-F-4-Cl CH3 Ph-3,4-Cl2 CH3 L-45c CH3 L-45d CH3 L-45e CH3 L-45g CH3 L-451 CH3 L-45m CH3 L-46c CH3 L-46d CH3 L-46e CH3 L-46g CH3 L-46j CH3 L-46k CH3 L-46q H s-Bu CH3 CF3 H s-Bu CH3 CF3 H s-Bu CH3 CF3 H s-Bu CH3 CF3 H s-Bu CH3 CF3 H s-Bu CH3 CF3 H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s - Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu H s-Bu CH3 L-46r H s-Bu CH3 L-47a
L-46g L-46j L - 46k L-46q L - 46r L_47a L-47e H
395 314918 200407073
s-Bu ch3 L-47e H t_Bii ch3 cf3 Ph-4-F t-Bu ch3 cf3 Ph-4-Cl t-Bu ch3 cf3 Ph-4-0CHF2 t_Bu ch3 cf3 Ph-4-0S02CH3 t-Bu ch3 cf3 Ph+SCH3 t - Bu ch3 cf3 Ph - 4-S(0)CH3 t - Bu ch3 cf3 Ph-4-S02CH3 t-Bu ch3 cf3 Ph-4-SCHF2 t-Bu ch3 cf3 Ph-4-S (0) CHF t - Bu ch3 cf3 Ph-4-S02CHF2 t~Bu ch3 cf3 Ph-4-SCF3 t-Bu ch3 cf3 Ph-4-S (0) CF3 t-Bu ch3 cf3 Ph_4-S02CF3 t-Bu ch3 cf3 Ph-4-CN t-Bu ch3 cf3 Ph-4-C (0) NH2 t-Bu ch3 cf3 Ph - 4-C(S)NH2 t-Bu ch3 cf3 Ph-3, 4-F2 t-Bu ch3 cf3 Ph-3-F+Cl t-Bu ch3 cf3 Ph-3, 4-Cl2 t_Bu ch3 cf3 L - 45c t-Bu ch3 cf3 L - 45d t-Bu ch3 cf3 L-45e t_Bu ch3 cf3 L-45g t-Bu ch3 cf3 L-45m t~Bu ch3 cf3 L - 46c t-Bu ch3 cf3 L-46d t-Bu ch3 c.f3 L - 46e t_Bu ch3 cf3 L-46g t-Bu ch3 cf3 L-46j t-Bu ch3 cf3 L-46k t-Bu ch3 cf3 L - 46q t-Bu ch3 cf3 L-46r t-Bu ch3 cf3 L-47a t-Bu ch3 cf3 L - 47e t-Bu ch3 Ph-4-F H t - Bu ch3 Ph+Cl H
396 314918 200407073 Η t - Bu ch3 Ph-4-Br H Η t - Bu ch3 Ph-4-CF 3 H Η t-Bu ch3 Ph-4-0CHF2 H Η t，Bu ch3 Ph-4-0CF3 H Η t-Bu ch3 Ph-4-0 (L-45g) H Η t - Bu ch3 Ph-4_SCF3 H Η t-Bu ch3 Ph-4-N02 H Η t-Bu ch3 Ph-4-CN H Η t-Bu ch3 Ph-4-C (0) NH2 H Η t-Bu ch3 Ph-4-C (S) NH2 H Η t-Bu ch3 Ph-3, 4-F2 H Η t-Bu ch3 Ph-3-F-4-Cl H Η t-Bu ch3 Ph-3, 4-Cl2 H Η t-Bu ch3 L-45c H Η t-Bu ch3 L-45d H Η 卜Bu ch3 L - 45e H Η t-Bu ch3 L-45g H Η 卜Bu ch3 L-451 H Η t-Bu ch3 L - 45m H Η t-Bu ch3 L-46c H Η t-Bu ch3 L-46d H Η t-Bu ch3 L - 46e H Η t-Bu ch3 L - 46g H Η t-Bu ch3 L-46j H Η t-Bu ch3 L - 46k H Η t-Bu ch3 L-46q H Η t-Bu ch3 L-46r H Η 卜Bu ch3 L-47a H Η t-Bu ch3 L-47e H Η CH(CH3)Pr - n ch3 cf3 Ph-4-F Η CH(CH3)Pr - n ch3 cf3 Ph-4-Cl Η CH(CH3)Pr - n ch3 CF3 Ph-4-0S02CH Η CH&lt;CH3)Pr - n ch3 cf3 Ph+SCH3 Η CH(CH3)P 卜 n ch3 cf3 Ph-4-S (0) CH； Η CH(CH3)Pr - n ch3 cf3 Ph-4-S02CH3 Η CH (CH3)Pr-n ch3 cf3 Ph-4-CN Η CH (CH3)Pr-n ch3 cf3 L-46d
397 314918 200407073
Η CH(CH3)Pr - η ch3 Ph-4-F H Η CH (CH3)Pr-n ch3 Ph-4-C1 H Η CH (CH3)Pr-n ch3 Ph-4-Br H Η CH(CH3)Pr - η ch3 Ph-4-CF3 H Η CH (CH3)Pr-n ch3 Ph-4-0CHF2 H Η CH (CH3)Pr-n ch3 Ph-4-0CF3 H Η CH(CH3)Pr - n ch3 Ph-4-0 (L-45g) H Η C(CH3) 2Et ch3 cf3 Ph-4-F Η C(CH3)2Ht ch3 cf3 Ph-4-Cl Η C(CH3) 2Et ch3 cf3 Ph-4-S02CH Η C(CH3) 2Et ch3 Ph-4-F H Η C(CH3) 2Et ch3 Ph+Cl H Η C(CH3)2Et ch3 Ph-4-Br H Η C(CH3)2Pr - n ch3 cf3 Ph_4-F Η C(CH3)2Pr-n ch3 cf3 Ph-4-Cl Η C(CH3) 2Pr-n ch3 cf3 Ph+S02CH Η C(CH3) 2Pr-n ch3 cf3 Ph-4_CN Η C(CH3) 2Pr-n ch3 cf3 L - 46d Η C(CH3) 2Pr-n ch3 Ph_4-F H Η C(CH3)2Pr-n ch3 Ph-4-Cl H Η C(CH3) 2Pr-n ch3 Ph-4-Br H Η C(CH3)2Pr-n ch3 Ph+CF3 H Η C(CH3) 2Pr-n ch3 Ph-4_0CHF2 H Η C(CH3) 2Pr_n ch3 Ph-4-0CF3 H Η C(CH3) 2Pr-n ch3 Ph-4-0 (L-45g) H -ch2ch2ch2ch2- ch3 Ph-4-Cl H -ch2ch2ch2ch2ch2- ch3 Ph-4-Cl H -ch2ch2ch2ch2ch2ch2-ch3 Ph-4-Cl H Η CH (CH3)CH2F ch3 cf3 Ph~4_F Η CH (CH3)CH2F ch3 cf3 Ph_4-C] Η CH (CH3)CH2F ch3 cf3 Ph-4-S02CH； Η CH (CH3)CH2F ch3 cf3 L-46d Η CH (CH3)CH2F ch3 Ph-4-F H Η CH (CH3)CH2F ch3 Ph-4-C1 H Η CH (CH3)CH2F(S) ch3 Ph-4-Cl H Η CH (CH3)CH2F ch3 Ph-4-Br H Η .CH (CH3)CH2F ch3 Ph~4~CF 3 H
398 314918 200407073
Η CH (CH3)CH2F ch3 Ph-4-0CHF2 H Η CH (CH3)CH2F ch3 Ph-4-0CF3 H Η CH (CH3)CH2F ch3 Ph-4-0 (L-45g) H Η CH (CH3)CH2C1 ch3 cf3 Ph-4-F Η CH (CH3)CH2C1 ch3 cf3 Ph-4-C1 Η CH (CH3)CH2C1 ch3 cf3 Ph_4-S02CH3 Η CH (CH3)CH2C1 ch3 cf3 L - 46d Η CH (CH3)CH2C1 ch3 Ph-4-F H Η CH (CH3)CH2C1 ch3 Ph-4-C1 H Η CH (CH3)CH2C1 ch3 Ph-4-Br H Η CH (CH3)CH2C1 ch3 Ph-4-CF3 H Η CH (CH3)CH2C1 ch3 Ph-4-0CHF2 H Η CH (CH3)CH2C1 ch3 Ph-4-0CF3 H Η CH (CH3)CH2C1 ch3 Ph-4-0 (L-45g) H Η c(ch3)2ch2ci ch3 cf3 Ph-4-F Η c(ch3) 2ch2ci ch3 cf3 Ph-4-C1 Η C(CH3)2CH2C1 ch3 cf3 Ph-4-S02CH3 Η C(CH3)2CH2C1 ch3 cf3 L-46d , Η C(CH3) 2CH2C1 ch3 Ph-4-F H Η C(CH3)2CH2C1 ch3 Ph-4-Cl H Η c(ch3)2ch2ci ch3 Ph-4-Br H Η c(ch3)2ch2ci ch3 Ph+CF3 H Η c(ch3) 2ch2ci ch3 Ph-4-0CHF2 H Η c(ch3)具Cl ch3 Ph-4-0CF3 H Η c(ch3) 2CH2C1 ch3 Ph-4-0 (L-45g) H Η CH2C(CH3)2OSi(CH3)3 ch3 cf3 Ph_4_F Η CH2C(CH3) 20Si (CH3) 3 ch3 cf3 Ph-4-Cl Η CH2C(CH3)2OSi(CH3)3 ch3 cf3 Ph-4-SCHa Η CH2C(CH3)2OSi(CH3)3 ch3 cf3 Ph+S (0) CH Η CH2C&lt;CH3)2OSi(CH3)3 ch3 cf3 Ph+S02CH3 Η CH2C(CH3) 20Si (CH3) a ch3 cf3 Ph+CN Η CH2C(CH3)2OSi(CH3)3 ch3 cf3 L - 46d Η CH2C(CH3)2OSi(CH3)3 ch3 Ph-4-F H Η CH2C(CH3) 2〇Si (CH3) a ch3 Ph-4-Cl H Η CH2C(CH3)2〇Si(CH3) a ch3 Ph-4-Br H Η C.H2C(CH3)2OSi(CH3)3 ch3 Ph+CF3 H Η CH2C(CH3) 2〇Si (CH3) a ch3 Ph-4-0CHF2 H
399 314918 200407073 Η CH2C(CH3) 2〇Si (CH3) 3 ch3 Ph-4-0CF3 H Η CH2C(CH3) 2〇Si (CH3) a ch3 Ph-4-0 (L-45g) H Η CH (CH3)CH20H ch3 cf3 Ph-4-Cl Η CH (CH3)CH20H ch3 cf3 Ph~4_Br Η CH (CH3)CH20H ch3 cf3 Ph-4-CF3 Η CH (CH3)CH20H ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH20H ch3 Ph-4-F H Η CH (CH3)CH20H ch3 Ph-4-C1 H Η CH (CH3)CH20H (R) ch3 Ph-4-Cl H Η CH (CH3)CH20H (S) ch3 Ph-4-C1 H Η CH (CH3)CH20H ch3 Ph-4-Br H Η CH (CH3)CH20H ch3 Ph-4-CF3 H Η CH (CH3)CH20H ch3 Ph-4-0CHF2 H Η CH (CH3)CH20H ch3 Ph-4-0CF3 H Η CH (CH3)CH20H ch3 Ph-4-0 (L-45g) H Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-F Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-Cl Η CH (CH3)CH20CH3 ch3 cf3 Ph_4-Br , Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-I Η CH (CH3)CH20CH3 ch3 cf3 Ph-4_CF 3 Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-0CHF2 Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-SCH3 Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-S (0) CH Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-S02CH3 Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-N02 Η CH (CH3)CH20CH3 ch3 cf3 Ph-4-CN Η CH (CH3)CH20CH3 ch3 cf3 Ph-3, 4-F2 Η CH (CH3)CH20CH3 ch3 cf3 Ph-3-F-4-Cl Η CH (CH3)CH20CH3 ch3 cf3 Ph - 3,4-Cl2 Η CH (CH3)CH20CH3 ch3 cf3 L-45d Η CH (CH3)CH20CH3 ch3 cf3 L - 45e Η CH (CH3)CH20CH3 ch3 cf3 L-45g Η CH (CH3)CH20CH3 ch3 cf3 L-45m Η CH (CH3)CH20CH3 ch3 cf3 L - 46d Η CH (CH3)CH20CH3 ch3 cf3 L - 46e Η CH (CH3)CH20CH3 ch3 cf3 L-46g
400 314918 200407073
Η CH (CH3)CH20CH3 ch3 cf3 L-46j Η CH (CH3)CH20CH3 ch3 cf3 L-46k Η CH (CH3)CH20CH3 ch3 cf3 L-46m Η CH (CH3)CH20CH3 ch3 cf3 卜46p Η CH (CH3)CH20CH3 ch3 cf3 L-46q Η CH (CH3)CH20CH3 ch3 cf3 L-46r Η CH (CH3)CH20CH3 ch3 cf3 L - 47a Η CH (CH3)CH20CH3 ch3 cf3 L-47e Η CH (CH3)CH20CH3 ch3 Ph-4-F H Η CH (CH3)CH20CH3 ch3 Ph-4-Cl H Η CH (CH3)CH20CH3 ch3 Ph-4-Br H Η CH (CH3)CH20CH3 ch3 Ph-4-CF3 H Η CH (CH3)CH20CH3 ch3 Ph-4-0CHF2 H Η CH (CH3)CH20CH3 ch3 Ph-4-0CF3 H Η CH (CH3)CH20CH3 ch3 Ph-4-0CF2Br H Η CH (CH3)CH20CH3 ch3 Ph-4-0CF2CHFCF3 H Η CH (CH3)CH20CH3 ch3 Ph-4-0CF2CHF0CF3 H Η CH (CH3)CH20CH3 ch3 Ph-4-0 (L-45g) H Η CH (CH3)CH20CH3 ch3 Ph-3,4-F2 H Η CH (CH3)CH20CH3 ch3 Ph~3_F~4_Cl H Η CH (CH3)CH20CH3 ch3 Ph - 3,4-Cl2 H Η CH (CH3)CH20CH3 ch3 L-45c H Η CH (CH3)CH2〇CH3 ch3 L-45d H Η CH (CH3)CH20CH3 ch3 L-45e H Η CH (CH3)CH20CH3 ch3 L_45g H Η CH (CH3)CH20CH3 ch3 L - 451 H Η CH (CH3)CH20CH3 ch3 L-45m H Η CH (CH3)CH20CH3 ch3 L - 46c H Η CH (CH3)CH20CH3 ch3 L-46d H Η CH (CH3)CH20CH3 ch3 L - 46e H Η CH (CH3)CH20CH3 ch3 L-46g H Η CH (CH3)CH20CH3 ch3 L-46j H Η CH (CH3)CH20CH3 ch3 L-46k H Η CH (CH3)CH20CH3 ch3 L - 46q H Η CH (CH3)CH20CH3 ch3 L-46r H Η CH (CH3)CH2〇CH3 ch3 L-47a H Η CH (CH3)CH20CH3 ch3 L-47e H
401 314918 200407073
Η ch(ch3)ch2oc(o)ch3 ch3 cf3 Ph-4-F Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-Cl Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-Br Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-1 Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-CF3 Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-0CHF2 Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-OCFs Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-OCF2Br Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-4-0CF2CHFCF Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-3, 4-F2 Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-3-F-4-Cl Η CH (CH3)CH20C (0) ch3 ch3 cf3 Ph-3, 4-Cl2 ' Η CH (CH3)CH20C (0) ch3 ch3 Ph_4-F H Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-C1 H Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-Br H Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-CF3 H Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-0CHF2 H Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-0CF3 H . Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-0 (L-45g) H Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-CN H Η CH (CH3)CH20C (0) ch3 ch3 Ph-3,4-Cl2 H Η CH (CH3)CH20C (0) nhch3 ch3 cf3 Ph-4-F Η CH (CH3)CH20C (0) nhch3 ch3 cf3 Ph-4-Cl Η CH (CH3)CH20C (0)NHCH3 ch3 cf3 Ph-4-Br Η CH (CH3)CH20C (0) NHCHa ch3 cf3 Ph-4-1 Η CH (CH3)CH20C (0) nhch3 ch3 cf3 Ph-4-CF3 Η CH (CH3)CH20C (0) nhch3 ch3 cf3 Ph-4-0CHF2 Η CH (CH3)CH20C (0) nhch3 ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH20C (0) nhch3 ch3 cf3 Ph~4-0CF2Br Η CH (CH3)CH20C (0) nhch3 ch3 cf3 Ph-4-0CF2CHF2 Η CH (CH3)CH20C (0)NHCH3 ch3 cf3 Ph-4-0CF2CHFCF Η CH (CH3)CH20C (0) nhch3 ch3 cf3 Ph-4-SCF3 Η CH (CH3)CH20C (0) nhch3 ch3 cf3 Ph-3,4_F2 Η CH (CH3)CH20C (0)NHCH3 ch3 cf3 Ph_3-F-4_C1 Η CH (CH3)CH20C (0)NHCH3 ch3 cf3 Ph-3,4-Cl2 Η CH (CH3)CH20C (0)NHCH3 ch3 Ph-4-F H Η CH (CH3)CH20C (O)NHCH, ch3 Ph-4-C1 H 402 314918 200407073
Η CH (CH3)CH20C (0) nhch3 ch3 Ph-4-Br H Η CH (CH3)CH20C (0) nhch3 ch3 Ph-4-CF3 H Η CH (CH3)CH20C (0) NHCH3 ch3 Ph-4-0CHF2 H Η CH (CH3)CH20C (0) nhch3 ch3 Ph-4-0CF3 H Η CH (CH3)CH20C (0) nhch3 ch3 Ph_4-OCFgBr H Η CH (CH3)CH20C (0) nhch3 ch3 Ph-4-0CF2CHF2 H Η CH (CH3)CH20C (0) nhch3 ch3 Ph-4-0CF2CHFCl H Η CH (CH3)CH20C (0) nhch3 ch3 Ph-4-0CF2CHFCF3 H Η ch(ch3)ch2oc(o)_3 ch3 Ph-4-0CF2CHF0CF3 H Η CH (CH3)CH2〇C (0) NHCHa ch3 Ph-4-0CF2CHF0CF2CF2CF3 H Η CH (CH3)CH20C (0) nhch3 ch3 Ph-4-0 (L-45g) H Η CH (CH3)CH20C (0) nhch3 ch3 Ph-4-SCF3 H Η CH (CH3)CH20C (0) nhch3 ch3 Ph-4-CN H Η CH (CH3)CH20C (0)NHCH3 ch3 Ph-3, 4-Cl2 H Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-4-F Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-4-Cl Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-4-Br Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-4-I Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-4-CF3 Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-4-0CHF2 Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-4-0CF2Br Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-4-0CF2CHF2 Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-4-0CF2CHFCF3 Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-4-0CF2CHF0CF3 Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-4-0CF2CHF0CF2CF2CF Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-4&quot;SCF3 Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-3,4-F2 Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-3-F-4-C1 Η CH (CH3)CH20C (0) NHEt ch3 cf3 Ph-3,4-Cl2 Η CH (CH3)CH20C (0) NHEt ch3 Ph~4~F H Η CH (CH3)CH20C (O)NHEt ch3 Ph-4-Cl H Η CH (CH3)CH2OC (0) NHEt ch3 Ph-4-Br H Η CH (CH3)CH2OC (0) NHEt ch3 Ph+CF3 H Η CH (CH3)CH2OC (O)NHEt ch3 Ph-4-0CHF2 H Η CH (CH3)CH2OC (0) NHEt ch3 Ph-4-OCF3 H Η CH (CH3)CH2OC (O)NHEt ch3 Ph-4-0CF2Br H
403 314918 200407073 H CH (CH3)CH20C (O)NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHEt H CH (CH3)CH2OC (0) NHPr-n H CH (CH3)CH2OC (0) NHPr-n H CH(CH3)CH20C(0)NHPr - n H CH (CH3)CH2OC (0) NHPr-n H CH (CH3)CH2OC (0) NHPr-n H CH (CH3)CH2OC (0) NHPr-n H CH (CH3)CH2OC (0) NHPr-n H CH (CH3)CH2OC (0) NHPr-n
Ph-4-F Ph-4-Cl Ph_4-Br Ph-4-CF3 Ph-4_0CHF2 Ph-4-0CF3 H H ch3 Ph-4-0CF2CHF2 ch3 Ph-4-0CF2CHFCl ch3 Ph-4-0CF2CHFCF3 ch3 Ph-4-0CF2CHF0CF3 ch3 Ph-4-0CF2CHF0CF2CF2CF ch3 Ph-4-0 (L-45g) ch3 Ph-4-SCF3 ch3 Ph-4-CN ch3 Ph-3, 4-F2 ch3 Ph-3-F-4-Cl ch3 Ph-3,4-Cl2 ch3 L-45c ch3 L-45d ch3 L-45e ch3 L-45f ch3 L - 45g ch3 L-451 ch3 L-45m ch3 L-46c ch3 L - 46d ch3 L - 46e ch3 L - 46i ch3 L-46g ch3 L-46i ch3 L - 46j ch3 L-46k ch3 L-46r ch3 L-47a ch3 L-47e ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 Ph-4-F ch3 Ph+Cl 404 314918 200407073 Η CH (CH3)CH20C (0) NHPr-n ch3 Ph-4-Br H Η CH (CH3)CH20C (0) NHPr-n ch3 Ph+CF3 H Η CH (CH3)CH20C (0) NHPr-n ch3 Ph-4-0CHF2 H Η CH (CH3)CH20C (0) NHPr-n ch3 Ph-4-0CF3 H Η CH (CH3)CH20C (0) NHPr-n ch3 Ph-4-0 (L - 45g) H Η CH (CH3)CH20C (0) NHPr-i ch3 cf3 Ph-4-F Η CH (CH3)CH20C (0) NHPr-i ch3 cf3 Ph-4-Cl Η CH (CH3)CH20C (0) NHPr-i ch3 cf3 Ph-4-Br Η CH (CH3)CH20C (0) NHPr-i ch3 cf3 Ph_4_CF3 Η CH (CH3)CH20C (0) NHPr-i ch3 cf3 Ph-4-0CHF Η CH(CH3)CH20C (0) NHPr-i ch3 cf3 Ph_4-0CF3 Η CH (CH3)CH20C (0) NHPr-i ch3 Ph-4-F H Η CH (CH3)CH20C (0) NHPr-i ch3 Ph-4-Cl H Η CH (CH3)CH20C (0) NHPr-i ch3 Ph-4-Br H Η CH (CH3)CH20C (0) NHPr-i ch3 Ph-4-CF3 H Η CH (CH3)CH20C (0) NHPr-i ch3 Ph-4-0CHF2 H Η CH (CH3)CH20C (0) NHPr-i ch3 Ph-4-0CF3 H Η CH (CH3)CH20C (0) NHPr-i ch3 Ph-4-0 (L-45g) H Η CH (CH3)CH20C (0) NHPr-c ch3 cf3 Ph-4-F Η CH (CH3)CH20C (0) NHPr-c ch3 cf3 Ph-4-C1 Η CH(CH3)CH20C ⑼ NHPr-c ch3 cf3 Ph-4-Br Η CH (CH3)CH20C (0) NHPr-c ch3 cf3 Ph+CF3 Η CH (CH3)CH20C (0) NHPr-c ch3 cf3 Ph-4-OCHF Η CH (CH3)CH20C (0) NHPr-c ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2〇C (0) NHPr-c ch3 Ph-4-F H Η CH (CH3)CH20C (0) NHPr-c ch3 Ph-4-C1 H Η CH(CH3)CH20C(0) NHPr-c ch3 Ph-4-Br H Η CH (CH3)CH20C (0) NHPr-c ch3 Ph-4-CF3 H Η CH (CH3)CH20C (0) NHPr-c ch3 Ph-4-0CHF2 H Η CH(CH3)CH20C(0) NHPr-c ch3 Ph-4-0CF3 H Η CH (CH3)CH20C (0) NHPr-c ch3 Ph-4 - 0(L - 45g) H Η CH (CH3)CH20C (0)NHCH2Ph ch3 cf3 Ph-4-F Η CH (CH3)CH20C (0)NHCH2Ph ch3 cf3 Ph-4-Cl Η CH(CH3)CH20C (0) NHCH2Ph ch3 cf3 Ph-4-Br Η CH (CH3)CH2〇C (0) NHCH2Ph ch3 cf3 Ph-4-CF3 Η CH (CH3)CH20C (0) NHCH2Ph ch3 cf3 Ph-4-OCHF Η CH (CH3)CH20C (0)NHCH2Ph ch3 cf3 Ph-4-0CF3
405 314918 200407073
Η CH (CH3)CH20C (0) NHCH2Ph ch3 Ph_4~F H Η CH (CH3)CH20C (0)NHCH2Ph ch3 Ph-4-C1 H Η CH (CH3)CH20C (0) NHCH2Ph ch3 Ph~4~Br H Η CH (CH3)CH20C (0) NHCH2Ph ch3 Ph-4-CF3 H Η CH (CH3)CH20C (0) NHCH2Ph ch3 Ph-4-0CHF2 H Η CH (CH3)CH20C (0) NHCH2Ph ch3 Ph-4-0CF3 H Η CH (CH3)CH20C (0) NHCH2Ph ch3 Ph-4-0 (L-45g) H Η CH (CH3)CH20C (0) NHPh ch3 CF3 Ph-4-F Η CH (CH3)CH20C (0) NHPh ch3 cf3 Ph-4-Cl Η CH (CH3)CH20C (0) NHPh ch3 cf3 Ph-4-Br Η CH (CH3)CH20C (0) NHPh ch3 cf3 Ph-4-CF3 Η CH (CH3)CH20C (0) NHPh ch3 cf3 Ph-4-0CHF Η CH (CH3)CH20C (0) NHPh ch3 CF3 Ph-4-0CF3 Η CH (CH3)CH20C (0) NHPh ch3 Ph-4_F H Η CH (CH3)CH20C (0) NHPh ch3 Ph-4_C1 H Η CH (CH3)CH20C (O)NHPh ch3 Ph-4-Br H Η CH (CH3)CH2OC (0) NHPh ch3 Ph-4-CF3 H Η CH (CH3)CH2OC (0) NHPh ch3 Ph-4-0CHF2 H . Η CH (CH3)CH2OC (O)iNHPh ch3 Ph-4-0CF3 H Η CH (CH3)CH20C (0) NHPh ch3 Ph-4-0 (L_45g) H Η CH (CH3)CH2OC (O)N(Et) 2 ch3 cf3 Ph-4-F Η CH (CH3)CH20C (O)N(Et) 2 ch3 cf3 Ph-4-Cl Η CH (CH3)CH2〇C (O)N(Et) 2 ch3 cf3 Ph~4~Br Η CH (CH3)CH2OC (O)N(Et) 2 ch3 cf3 Ph_4-CF3 Η CH (CH3)CH20C (0)N(Et)2 ch3 cf3 Ph-4-0CHF Η CH (CH3)CH2OC (0)N(Et)2 ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2OC (O)N(Et) 2 ch3 Ph_4_F H Η CH (CH3)CH2OC (O)N(Et) 2 ch3 Ph+Cl H Η CH (CH3)CH2OC (0)N(Et)2 ch3 Ph~4~Br H Η CH (CH3)CH2OC (O)N(Et) 2 ch3 Ph-4-CF3 H Η CH (CH3)CH2OC (0)N(Et)2 ch3 Ph-4-0CHF2 H Η CH (CH3)CH20C (0)N(Et)2 ch3 Ph-4-0CF3 H Η CH (CH3)CH2OC (0)N(Et)2 ch3 Ph-4-0 (L_45g) H Η CH(CH3)CH2OP(S) (OCH3) 2 ch3 cf3 Ph~4-F Η CH(CH3)CH2OP(S) (OCH3) 2 ch3 CF3 Ph-4-Cl Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 cf3 Ph-4-Br Η CH(CH3)CH2OP(S) (OCH3) 2 ch3. cf3 Ph-4-I
406 314918 200407073
Η CH(CH3)CH20P(S) (0CH3) 2 ch3 cf3 Ph_4-CF3 Η CH(CH3)CH20P ⑸（0CH3) 2 ch3 cf3 Ph-4-0CHF2 Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 cf3 PI1-4-OCF3 Η CH(CH3)CH2OP(S) (〇ch3) 2 ch3 cf3 Ph-4-OCF2Br Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 cf3 Ph-4-0CF2CHF2 Η CH(CH3)CH20P ⑸（0CH3) 2 ch3 cf3 Ph-4-0CF2CHFCF3 Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 cf3 Ph-4-SCF3 Η CH(CH3)CH20P ⑸（0CH3) 2 ch3 cf3 Ph-3, 4-F2 Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 cf3 Ph-3-F-4-C1 Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 cf3 Ph-3, 4-Cl2 Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph-4-F H Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph+Cl H Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph-4-Br H Η CH(CH3)CH20P ⑸（0CH3) 2 ch3 Ph+CF3 H Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph-4-0CHF2 H Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph-4-OCF3 H Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph-4-0CF2Br H Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph-4-0CF2CHF2 H . Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Pli - 4-0CF2CHFCl H Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph-4-0CF2CHFCF3 H Η CH(CH3)CH20P ⑸（0CH3) 2 ch3 Ph-4-0CF2CHF0CF3 H Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph-4-0CF2CHF0CF2CF2CF3 H Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph-4-0 (L-45g) H Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph-4-SCF3 H Η CH(CH3)CH2OP(S) (0CH3) 2 ch3 Ph-4-CN H Η CH(CH3)CH20P ⑸（0CH3) 2 ch3 Ph-3,4-Cl2 H Η CH(CH3)CH2OP(S) (0Et)2 ch3 cf3 Ph-4-F Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-4-Cl Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-4-Br Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph+I Η CH(CH3)CH2OP(S) (OEt)2 ch3 cf3 Ph~*4-CF 3 Η CH(CH3)CH2OP(S) (OEt)2 ch3 cf3 Ph-4-OCHF 2 Η CH(CH3)CH2OP(S) (OEt)2 ch3 cf3 Ph-4-0CF3 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-4-OCF2Br Η CH(CH3)CH2OP(S) (OEt)2 ch3 cf3 Ph-4-0CF2CHF2 Η CH(CH3)CH2OP ⑸（OEt) 2 ch3 cf3 Ph-4-0CF2CHFCF3 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-4-0CF2CHF0CF 407 314918 200407073
Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-4-OCF2CHFOCF2CF2CF3 Η CH(CH3)CH2OP(S) (ΟΕΟ 2 ch3 cf3 Ph-4-SCF3 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-3, 4-F2 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-3-F-4-C1 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 cf3 Ph-3, 4-Cl2 Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph-4-F H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph-4-Cl H Η CH(CH3&gt;CH2OP(S) (OEt) 2 ch3 Ph-4-Br H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph+CF3 H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph-4-0CHF2 H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph-4-OCF3 H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph-4-OCF2Br H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph-4-0CF2CHF2 H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph - [0CF2CHFC1 H Η CH(CH3)CH2OP® _ 2 ch3 Ph-4-0CF2CHFCF3 H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph-4-0CF2CHF0CF； 3 H Η CH(CH3)CH2OP(S) (OEt)2 ch3 Ph-4-0CF2CHF0CF； 2cf2cf3 h Η CH(CH3)CH2OP ⑸ _2 ch3 Ph-4-0 (L-45g) H . Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph+SCF3 H Η CH(CH3)CH20P(S) (OEt) 2 ch3 Ph+CN H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph - 3,4-F2 H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 Ph-3_F-4_C1 H Η CH(CH3)CH2OP ⑸（OEt) 2 ch3 Ph-3, 4-Cl2 H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 L - 45c H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 L_45d H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 L-45e H Η CH(CH3)CH20P(S) (OEt) 2 ch3 L-46f H Η CH(CH3)CH20P(S) (OEt) 2 ch3 L - 45g H Η CH(CH3)CH2OP(S) (OEt)2 ch3 L - 451 H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 L-45m H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 L - 46c H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 L-46d H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 L-46e H Η CH(CH3)CH2OP(S) (OEt)2 ch3 L-46g H Η CH(CH3)CH2OP(S) (OEt)2 ch3 L-46i H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 L - 46j H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 L-46k H
408 314918 200407073
Η CH(CH3)CH2OP(S) (OEt) 2 ch3 L-46r H Η CH(CH3)CH2OP(S) (OEt) 2 ch3 L - 47a H Η CH(CH3)CH2OP ⑸（OEt)2 ch3 L-47e H Η CH(CH3)CH20(Ph-4 - Cl) ch3 cf3 Ph-4-F Η CH(CH3)CH20(Ph-4 - Cl) ch3 cf3 Ph+Cl Η CH (CH3)CH20(Ph-4-Cl) ch3 cf3 Ph-4_SCH3 Η CH(CH3)CH20(PlHhCl) ch3 cf3 Ph-4-S (0) CH Η CH(CH3)CH20(Ph-4 - Cl) ch3 cf3 Ph-4-S02CH3 Η CH(CH3)CH20(Ph-4-Cl) ch3 cf3 Ph-4-CN Η CH(CH3)CH20(Ph+Cl) ch3 Ph~4_F H Η CH(CH3)CH20(Ph-4-C1) ch3 Ph-4-Cl H Η CH (CH3)CH20(Ph-4-Cl) ch3 Ph-4-Br H Η CH (CH3)CH20(Ph-4-CI) ch3 Ph-4-CF3 H Η CH(CH3)CH20(Ph+Cl) ch3 Ph-4-OCHF2 H Η CH (CH3)CH20(Ph-4-Cl) ch3 Ph-4-0CF3 H Η CH(CH3)CH20(Ph - 4-C1) ch3 Ph-4-0 (L-45g) H Η CH(CH3)CH20(Ph-4 - Cl) ch3 Ph-4-SCH3 H Η CH(CH3)CH20(Ph-4 - Cl) ch3 Ph+S (0) CH3 H Η CH(CH3)CH20(Ph-4-Cl) ch3 Ph-4-S02 CH3 H Η CH (CH3)CH20(Ph-4-Cl) ch3 Ph+N02 H Η CH(CH3)CH20(Ph-4 - Cl) ch3 Ph-4-CN H Η CH (CH3)CH20(Ph-4-Cl) ch3 Ph - 4-C(0)NH2 H Η CH(CH3)CH20(PlHhCl) ch3 Ph-4-C (S) NH2 H Η CH(CH3)CH20(Ph-4-Cl) ch3 L-45c H Η CH (CH3)CH20(Ph-4-Cl) ch3 L-45d H Η CH (CH3)CH20(Ph-4-Cl) ch3 L-45e H Η CH (CH3)CH20(Ph-4-Cl) ch3 L-46f H Η CH (CH3)CH20(Ph-4-Cl) ch3 L - 45g H Η CH (CH3)CH20(Ph-4-Cl) ch3 L - 451 H Η CH(CH3)CH20(Ph-4 - Cl) ch3 L - 45m H Η CH(CH3)CH20(Ph+Cl) ch3 L-46c H Η CH(CH3)CH20(Ph-4 - Cl) ch3 L-46d H Η CH (CH3)CH20(Ph-4-Cl) ch3 L-46e H Η CH (CH3)CH20(Ph-4-Cl) ch3 L_46g H Η CH(CH3)CH20(Ph-4 - Cl) ch3 L - 46i H Η CH(CH3)CH20(Ph-4 - Cl) ch3 L-46j H Η CH (CH3)CH20(Ph-4-Cl) ch3 L-46k H
409 314918 200407073
Η CH (CH3)CH20(Ph-4-Cl) ch3 L - 46r H Η CH(CH3)CH20(Ph-4-Cl) ch3 L - 47a H Η CH(CH3)CH20(Ph-4 - Cl) ch3 L-47e H Η C(CH3) 2ch2och3 ch3 CFs Ph-4-F Η C(CH3) 2ch2och3 ch3 cf3 Ph-4-Cl Η C(CH3) 2ch2och3 ch3 cf3 Ph+Br Η C(CH3)2CH20CH3 ch3 cf3 Ph+I Η C(CH3) 2ch2och3 ch3 CFs Ph-4-CF3 Η c(ch3) 2ch2och3 ch3 cf3 Ph-4-0CHF2 Η C(CH3) 2ch2och3 ch3 cf3 Ph-4-0CF3 Η C(CH3) 2ch2och3 ch3 cf3 Ph-4-N02 Η C(CH3) 2ch2och3 ch3 cf3 Ph-4-CN Η C(CH3) 2ch2och3 ch3 cf3 Ph-3,4_F2 Η c(ch3)2ch2och3 ch3 cf3 Ph-3~F-4~C1 Η c(ch3)具och3 ch3 cf3 Ph-3,4-Cl2 Η C(CH3) 2ch2och3 ch3 cf3 L_45d Η C(CH3) 2ch2och3 ch3 cf3 L-45e Η C(CH3) 2ch2och3 ch3 cf3 L-45g Η c(ch3) 2ch2och3 ch3 cf3 L~45in Η C(CH3) 2ch2och3 ch3 cf3 L-46d Η C(CH3) 2ch2och3 ch3 cf3 L-46e Η C(CH3) 2ch2och3 ch3 cf3 L-46g Η C(CH3) 2ch2och3 ch3 cf3 L - 46j Η c(ch3) 2ch2och3 ch3 cf3 L-46k Η C(CH3) 2ch2och3 ch3 cf3 L-46m Η C(CH3) 2ch2och3 ch3 cf3 L-46p Η C(CH3) 2ch2och3 ch3 cf3 L - 46q Η C(CH3) 2ch2och3 ch3 cf3 L - 46r Η c(ch3) 2ch2och3 ch3 cf3 L-47a Η c(ch3) 2ch2och3 ch3 cf3 L-47e Η C(CH3) 2ch2och3 ch3 Ph-4-F H Η C(CH3) 2ch2och3 ch3 Ph-4-Cl H Η c(ch3)2ch2och3 ch3 Ph_4~Br H Η c(ch3) 2ch2och3 ch3 Ph~4~CF 3 H Η C(CH3) 2CH2OCH3 ch3 Ph+0CHF2 H Η C(CH3) 2ch2och3 ch3 Ph+0CF3 .H Η c(ch3) 2ch2och3 ch3 Ph-4-0CF2Br H
410 314918 200407073 ch3 Ph-4-0CF2CHFCF3 ch3 Ph-4-0CF2CHF0CF ch3 Ph-4-0 (L - 45g) ch3 Ph-3,4-F2 ch3 Ph-3-F-4-C1 ch3 Ph-3,4-Cl2 ch3 L - 45c ch3 L - 45d ch3 L - 45e ch3 L-45g ch3 L-451 ch3 L - 45m ch3 L - 46c ch3 L - 46d ch3 L-46e ch3 L - 46g ch3 L-46j ch3 L - 46k ch3 L-46q ch3 L-46r ch3 L-47a ch3 L~47e ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3)2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3)2CH20CH3 H C(CH3)2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3) 2CH20CH3 H C(CH3)2CH20CH3 H C(CH3)2CH20CH3 H C(CH3)2CH20C (0) nhch3 H C(CH3) 2CH20C (0) nhch3 H C(CH3) 2CH20C (0) nhch3 H C(CH3)2CH20C (0)NHCH3 H C(CH3) 2CH20C (0) NHCHs H C(CH3) 2CH20C (0)NHCH3 H C(CH3)2CH20C (0) nhch3 H C(CH3)2CH20C (0) nhch3 h c(ch3) 2ch2oc(o)nhch3 H C(CH3)2CH20C (0)NHCH3 H C(CH3)2CH20C (0) nhch3 H C(CH3)2CH20C (0) NHCHa H C(CH3) 2ch2oc (0)NHCH3 h c(ch3) 2ch2oc(o)nhch3 H C(CH3) 2ch2oc (0)NHCH3
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Ph+F Ph-4-Cl Ph-4-Br Ph-4-I Ph-4-CF3 Ph-4-0CHF2 Ph-4-0CF3 Ph-4-0CF2Br Ph-4-0CF2CHF2 Ph-4-0CF2CHFCF3 Ph-4-0CF2CHF0CF3 Ph-4-0CF2CHFCF2CF20CF Ph-4-SCF3 Ph-3, 4-F2 Ph-3-F-4-Cl 411 314918 200407073
Η C(CH3) 2CH20C (0) nhch3 ch3 cf3 Ph-3,4-Cl2 Η C(CH3) 2CH20C (0) nhch3 ch3 Ph-4-F H Η C(CH3) 2CH20C (0) nhch3 ch3 Ph-4-Cl H Η C(CH3) 2CH20C (0)NHCH3 ch3 Ph~4_Br H Η c(ch3) 2ch2oc(o)nhch3 ch3 Ph-4-CF3 H Η C(CH3)2CH20C (0) NHCHs ch3 Ph-4-0CHF2 H Η C(CH3) 2CH20C (0) nhch3 ch3 Ph-4-0CF3 H Η C(CH3) 2CH20C (0) nhch3 ch3 Ph+OCF2Br H Η C(CH3) 2CH20C (0)NHCH3 ch3 Ph-4-0CF2CHF2 H Η C(CH3) 2CH20C (0) nhch3 ch3 Ph-4-0CF2CHFCl H Η C(CH3) 2CH20C (0) nhch3 ch3 Ph-4-0CF2CHFCF3 H Η C(CH3) 2CH20C (0)NHCH3 ch3 Ph-4-0CF2CHF0CF3 H. Η C(CH3) 2CH20C (0) nhch3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 H Η C(CH3) 2CH20C (0) nhch3 ch3 Ph-4-0 (L-45g) H Η C(CH3) 2CH20C (0) nhch3 ch3 Ph-4_SCF 3 H Η C(CH3) 2CH20C (0) nhch3 ch3 Ph-4-CN H Η C(CH3) 2CH20C (0) nhch3 ch3 Ph-3, 4-F2 H Η c(ch3) 2ch2oc(o)nhch3 ch3 Ph-3-F-4-Cl H Η c(ch3) 2ch2oc(o)nhch3 ch3 Ph-3, 4-Cl2 H Η C(CH3) 2CH20C (0)NHCH3 ch3 L-45c H Η C(CH3) 2CH20C (0) nhch3 ch3 L-45d H Η C(CH3) 2CH20C (0) nhch3 ch3 L - 45e H Η C(CH3) 2CH20C (0) nhch3 ch3 L-45f H Η c(ch3) 2ch2oc(o)_3 ch3 L-45g H Η C(CH3) 2CH20C (0) nhch3 ch3 L-451 H Η C(CH3) 2CH20C (0)NHCH3 ch3 L-45m H Η C(CH3) 2CH20C (0) nhch3 ch3 L - 46c H Η C(CH3) 2CH20C (0)NHCH3 ch3 L - 46d H Η C(CH3) 2CH20C (0)NHCH3 ch3 L-46e H Η C(CH3) 2CH20C (0) nhch3 ch3 L-46f H Η C(CH3) 2CH20C (0) NHCHa ch3 L - 46g H Η c(ch3) 2ch2oc(o)nhch3 ch3 L - 46j H Η C(CH3) 2CH20C (0) nhch3 ch3 L - 46k H Η C(CH3) 2ch2oc (0)NHCH3 ch3 L - 46r H Η C(CH3) 2CH20C (0)NHCH3 ch3 卜47a H Η C(CH3) 2ch2oc (0)NHCH3 ch3 L-47e H Η C(CH3) 2CH20C (O)NHEt ch3 cf3 Ph-4-F
412 314918 200407073 Η C(CH3) 2CH20C (0) NHEt ch3 cf3 Ph-4-Cl Η C(CH3) 2CH20C (0) NHEt ch3 cf3 Ph_4-Br Η C(CH3) 2CH20C (0) NHEt ch3 cf3 Ph-4-I Η C(CH3) 2CH20C ¢0) NHEt ch3 cf3 Ph-4-CF3 Η C(CH3) 2CH20C (O)NHEt ch3 cf3 Ph-4-OCHF2 Η C(CH3) 2CH2OC (0) NHEt ch3 cf3 Ph-4-OCF3 Η C(CH3) 2CH2OC (0) NHEt ch3 cf3 Ph-4-〇CF2Br Η C(CH3) 2CH2OC (0) NHEt ch3 cf3 Ph-4-0CF2CHF Η C(CH3) 2CH2OC (0) NHEt ch3 cf3 Ph-4-0CF2CHFCF Η .C(CH3) 2CH20C(0)NHEt ch3 cf3 Ph-4_SCF3 Η C(CH3) 2CH2OC (0) NHEt. ch3 cf3 Ph-3,4-F2 Η C(CH3) 2CH2OC (0) NHEt ch3 cf3 Ph-3~F-4-C1 Η C(CH3) 2CH2OC (0) NHEt ch3 cf3 Ph-3,4_C12 Η C(CH3) 2CH2OC (0) NHEt ch3 Ph-4-F H Η C(CH3) 2CH2OC (0) NHEt ch3 Ph+Cl H Η C(CH3) 2CH2OC (0) NHEt ch3 Ph-4-Br H Η C(CH3) 2CH2OC (O)NHEt ch3 Ph-4-CF3 H Η C(CH3) 2CH2OC (0) NHEt ch3 Ph-4-0CHF2 Ά Η C(CH3) 2CH2OC (O)NHEt ch3 Ph-4-0CF3 H Η C(CH3) 2CH2OC (0) NHEt ch3 Ph-4-OCF2Br H Η C(CH3) 2CH2OC (0) NHEt ch3 Ph-4-0CF2CHF2 H Η C(CH3) 2CH2OC (0) NHEt ch3 Ph~4-0CF2CHFC1 H Η C(CH3) 2CH2OC (O)NHEt ch3 Ph-4-0CF2CHFCF3 H Η C(CH3) 2CH2OC (0) NHEt ch3 Ph-4-0CF2CHF0CF3 H Η C(CH3) 2CH2OC (0) NHEt ch3 Ph-4-0CF2CHF0CF2CF2CF3 H Η C(CH3) 2CH2OC (O)NHEt ch3 Ph-4-0 (L-45g) H Η C(CH3) 2CH2OC (0) NHEt ch3 Ph-4-SCF3 H Η C(CH3) 2CH2OC (0) NHEt ch3 Ph-4-CN H Η C(CH3) 2CH2OC (O)NHEt ch3 Ph-3, 4-F2 H Η C(CH3) 2CH2OC (O)NHEt ch3 Ph-3-F-4-C1 H Η C(CH3) 2CH2OC (0) NHEt ch3 Ph-3, 4-Cl2 H Η C(CH3) 2CH20C(0)NHPr-n ch3 cf3 Ph-4-F Η C(CH3)2CH2OC (0) NHPr-n ch3 cf3 Ph-4-C1 Η C(CH3) 2CH2OC (O)NHPr-n ch3 cf3 Ph_4-Br Η C(CH3) 2CH2OC (0) NHPr-n ch3 cf3 Ph-4-CF3 Η C(CH3) 2CH2OC (0) NHPr-n ch3 cf3 Ph-4-0CHF2 Η C(CH3) 2CH2OC (0) NHPr-n ch3 cf3 Ph-4-0CF3
413 314918 200407073 Η C(CH3) 2CH20C (O)NHPr-n ch3 Η C(CH3) 2CH2OC (O)NHPr-n ch3 Η C(CH3) 2CH20C(0)NHPr-n ch3 Η C(CH3) 2CH2OC (O)NHPr-n ch3 Η C(CH3) 2CH2OC (O)NHPr-n ch3 Η C(CH3) 2CH2OC (0) NHPr-n ch3 Η C(CH3) 2CH2OC (0) NHPr-n ch3 Η C(CH3) 2CH2OC (0) NHCH2Ph ch3 Η C(CH3) 2CH2OC (0)NHCH2Ph ch3 Η C(CH3) 2CH2OC (0)NHCH2Ph ch3 Η C(CH3) 2CH2OC (0)NHCH2Ph ch3 Η C(CH3) 2CH2OC (0)NHCH2Ph ch3 Η C(CH3) 2CH2OC (0)NHCH2Ph ch3 Η C(CH3) 2CH2OC (0)NHCH2Ph ch3 Η C(CH3) 2CH2OC (0) NHCH2Ph ch3 Η C(CH3) 2CH2OC (0) NHCH2Ph ch3 Η C(CH3) 2CH20C(0)NHCH2Ph ch3 Η C(CH3) 2CH2OC (0) NHCH2Ph ch3 Η C(CH3) 2CH2OC (0)NHCH2Ph ch3 Η C(CH3) 2CH2OC (0)NHCH2Ph ch3 Η C(CH3)2CH2OC (0)N(CH3)2 ch3 Η c(ch3)2ch2oc(o)n(ch3)2 ch3 Η C(CH3) 2CH2OC (0)N(CH3) 2 ch3 Η C(CH3) 2CH2OC (0)N(CH3) 2 ch3 Η C(CH3) 2CH2OC (0)N(CH3) 2 ch3 Η C(CH3) 2CH2OC (0)N(CH3)2 ch3 Η C(CH3) 2CH2OC (0)N(CH3) 2 ch3 Η C(CH3)2CH2OC (0)N(CH3)2 ch3 Η C(CH3) 2CH2OC (0)N(CH3) 2 ch3 Η C(CH3) 2CH2OC (0)N(CH3) 2 ch3 Η C(CH3) 2CH2OC (0)N(CH3)2 ch3 Η C(CH3)2CH2OC (0)N(CH3)2 ch3 Η C(CH3) 2CH2OC (0)N(CH3) 2 ch3 Η CH (CH3)CH2CH2OEt ch3 Η CH (CH3)CH2CH2OEt ch3 Η CH (CH3)CH2CH2OEt ch3 Η CH (CH3)CH2CH2OEt ch3 4】4
Ph_4-F H Ph-4-Cl H Ph-4-Br H Ph-4-CF3 H Ph-4-0CHF2 H Ph-4-OCF3 H Ph-4-0 (L - 45g) H cf3 Ph+F cf3 Ph-4-Cl cf3 Ph-4-Br cf3 Ph-4-CF3 cf3 Ph-4-0CHF cf3 Ph-4-0CF3 Ph-4-F H Ph-4-Cl H Ph-4-Br H Ph-4-CF3 H Ph-4-0CHF2 H . Ph-4-0CF3 H Ph - 4-0 (L-45g) H cf3 Ph-4-F cf3 Ph-4-C1 cf3 Ph-4-Br cf3 Ph-4-CF3 cf3 Ph-4-OCHF cf3 Ph-4-0CF3 Ph-4~F H Ph-4-Cl H Ph-4-Br H Ph-4-CF3 H Ph-4-0CHF2 H Ph-4-0CF3 H Ph - 4-0(L - 45g) H cf3 Ph-4-F cf3 Ph-4-C1 cf3 Ph-4-Br cf3 Ph~4~CF 3
314918 200407073 Η CH (CH3)CH2CH20Et ch3 cf3 Ph-4-0CHF2 Η CH (CH3)CH2CH20Et ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2CH2OEt ch3 Ph_4_F H Η CH (CH3)CH2CH20Et ch3 Ph+Cl H Η CH (CH3)CH2CH2OEt ch3 Ph-4-Br H Η CH (CH3)CH2CH2OEt ch3 Ph-4-CF3 H Η CH (CH3)CH2CH2OEt ch3 Ph-4-0CHF2 H Η CH (CH3)CH2CH2OEt ch3 Ph-4-0CF3 H Η CH (CH3)CH2CH20Et ch3 Ph-4-0C.F2Br H Η CH (CH3)CH2CH20Et ch3 Ph-4-0CF2CHF2 H Η CH (CH3)CH2CH2OEt ch3 Ph-4-0CF2CHFCl H Η CH (CH3)CH2CH20Et ch3 Ph-4-0CF2CHFCF3 H Η CH (CH3)CH2CH20Et ch3 Ph-4-0CF2CHF0CF3 H Η CH (CH3)CH2CH2OEt ch3 Ph-4-0CF2CHF0CF2CF2CF3 H Η CH (CH3)CH2CH2OEt ch3 Ph - 4-0(L-45g) H Η CH (CH3)CH2CH2OEt ch3 Ph-4-SCF3 H Η CH (CH3)CH2CH2OEt ch3 Ph-4-CN H Η CH (CH3)CH2CH2OEt ch3 Ph-3, 4-F2 H . Η CH (CH3)CH2CH2OEt ch3 Ph_3-F-4-C1 H Η CH (CH3)CH2CH2OEt ch3 Ph-3, 4-Cl2 H Η CH (CH3)CH2SCH3 F cf3 Ph-4-F Η CH (CH3)CH2SCH3 F cf3 Ph-4-Cl Η CH (CH3)CH2SCH3 F cf3 Ph-4·Βγ Η CH (CH3)CH2SCH3 F cf3 Ph-4-CF3 Η CH (CH3)CH2SCH3 F cf3 Ph-4-0CHF2 Η CH (CH3)CH2SCH3 F cf3 Ph-4-0CF3 Η CH (CH3)CH2SCH3 F cf3 Ph-3,4_C12 Η CH (CH3)CH2SCH3 F Ph-4-F H Η CH (CH3)CH2SCH3 F Ph-4-C1 H Η CH (CH3)CH2SCH3 F Ph-4-Br H Η c_3)ch2sch3 F Ph-4-CF3 H Η CH (CH3)CH2SCH3 F Ph-4-0CHF2 H Η CH(CH3)CH2SCH3 F Ph-4-0CF3 H Η CH (CH3)CH2SCH3 F Ph - 4-0 (L-45g) H Η CH (CH3)CH2SCH3 F Ph-3, 4-Cl2 H Η CH (CH3)CH2SCH3 Cl CF3 Ph-4-F Η CH (CH3)CH2SCH3 Cl cf3 Ph-4-Cl
415 314918 200407073 Η CH (CH3)CH2SCH3 Cl cf3 Ph+Br Η CH (CH3)CH2SCH3 Cl cf3 Ph-4-CF3 Η CH (CH3)CH2SCH3 Cl cf3 Ph-4-0CHF2 Η CH (CH3)CH2SCH3 Cl cf3 Ph-4-0CF3 Η CH (CH3)CH2SCH3 Cl cf3 Ph-3,4-Cl2 Η CH (CH3)CH2SCH3 Cl Ph-4-F H Η CH (CH3)CH2SCH3 Cl Ph-4-Cl H Η CH (CH3)CH2SCH3 Cl Ph-4-Br H Η CH (CH3)CH2SCH3 Cl Ph+CF3 H Η CH (CH3)CH2SCH3 Cl Ph-4-0CHF2 H Η CH (CH3)CH2SCH3 Cl Ph-4-0CF3 H Η CH (CH3)CH2SCH3 Cl Ph-4-0 (L-45g) H Η CH (CH3)CH2SCH3 Cl Ph-3, 4-Cl2 H Η CH (CH3)CH2SCH3 Br cf3 Ph-4-F Η CH (CH3)CH2SCH3 Br cf3 Ph-4-C1 Η CH (CH3)CH2SCH3 Br cf3 Ph-4-Br Η CH (CH3)CH2SCH3 Br cf3 Ph-4-CF3 Η CH (CH3)CH2SCH3 Br cf3 Ph-4-0CHF2 Η CH (CH3)CH2SCH3 Br cf3 Ph-4-0CF3 Η CH (CH3)CH2SCH3 Br cf3 Ph-3,4_C12 Η CH (CH3)CH2SCH3 Br Ph-4-F H Η CH (CH3)CH2SCH3 Br Ph-4-Cl H Η CH (CH3)CH2SCH3 Br Ph+Br H Η CH (CH3)CH2SCH3 Br Ph-4-CF3 H Η CH (CH3)CH2SCH3 Br Ph-4-0CHF2 H Η CH (CH3)CH2SCH3 Br Ph-4-0CF3 H Η CH (CH3)CH2SCH3 Br Ph-4-0 (L-45g) H Η CH (CH3)CH2SCH3 Br Ph-3, 4-Cl2 H Η CH (CH3)CH2SCH3 ch3 H Ph Η CH (CH3)CH2SCH3 ch3 H Ph-4-Cl Η ch(ch3)ch2sch3 ch3 F Ph~4~F Η CH (CH3)CH2SCH3 ch3 F Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 F Ph-4-Br Η CH (CH3)CH2SCH3 ch3 F Ph+CF3 Η CH (CH3)CH2SCH3 ch3 F Ph-4-0CHF2 Η CH (CH3)CH2SCH3 ch3 F Ph-4-0CF3 Η CH (CH3)CH2SCH3 ch3 F Ph-3, 4-Cl2
416 314918 200407073 Η CH (CH3)CH2SCH3 ch3 Cl Ph-4_F Η ch(ch3)ch2sch3 ch3 Cl Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 Cl Ph+Br Η CH (CH3)CH2SCH3 ch3 Cl Ph-4-I Η CH (CH3)CH2SCH3 ch3 Cl Ph-4-CF3 Η CH (CH3)CH2SCH3 ch3 Cl Ph-4-0CHF2 Η CH (CH3)CH2SCH3 ch3 Cl Ph-4-0CF3 Η CH (CH3)CH2SCH3 ch3 Cl Ph-4-0CF2Br Η CH (CH3)CH2SCH3 ch3 Cl Ph-4~0CF2CHF2 Η CH (CH3)CH2SCH3 ch3 Cl Ph-4-0CF2CHFCl Η CH (CH3)CH2SCH3 ch3 Cl Ph-4-0CF2CHFCF3 Η CH (CH3)CH2SCH3 ch3 Cl Ph-4-0CF2CHF0CF Η CH (CH3)CH2SCH3 ch3 Cl Ph-4-0 (L-45g) Η CH (CH3)CH2SCH3 ch3 Cl Ph-3,4-Cl2 Η CH (CH3)CH2SCH3 ch3 Br Ph_4，F Η CH (CH3)CH2SCH3 ch3 Br Ph+Cl Η CH (CH3)CH2SCH3 ch3 Br Ph+Br Η CH (CH3)CH2SCH3 ch3 Br Ph-4_CF3 Η CH (CH3)CH2SCH3 ch3 Br Ph-4-0CHF2 Η CH (CH3)CH2SCH3 ch3 Br Ph-4-0CF3 Η CH (CH3)CH2SCH3 ch3 Br Ph-3, 4-Cl2 Η CH (CH3)CH2SCH3 ch3 ch3 Ph_4-F Η CH (CH3)CH2SCH3 ch3 ch3 Ph-4-CI Η CH (CH3)CH2SCH3 ch3 ch3 Ph_4_Br Η CH (CH3)CH2SCH3 ch3 ch3 Ph-4-CF3 Η CH (CH3)CH2SCH3 ch3 ch3 Ph-4-0CHF2 Η CH (CH3)CH2SCH3 ch3 ch3 Ph_4~0CF 3 Η CH (CH3)CH2SCH3 ch3 ch3 Ph-4-0CF2Br Η CH (CH3)CH2SCH3 ch3 ch3 Ph-4-0CF2CHFCF3 Η CH (CH3)CH2SCH3 ch3 ch3 Ph-3, 4-F2 Η CH (CH3)CH2SCH3 ch3 ch3 Ph-3-F-4-Cl Η CH (CH3)CH2SCH3 ch3 ch3 Ph - 3,4-(：12 Η CH (CH3)CH2SCH3 ch3 ch3 L-46d Η CH (CH3)CH2SCH3 ch3 Et Ph~4~F Η CH (CH3)CH2SCH3 ch3 Et Ph-4-C1 Η CH (CH3)CH2SCH3 ch3 Et Ph-4-Br Η CH (CH3)CH2SCH3 ch3 Et Ph-4-CF3
417 314918 200407073 Η CH (CH3)CH2SCH3 ch3 Et Ph-4-0CHF2 Η ch(ch3)ch2sch3 ch3 Et Ph-4-0CF3 Η CH (CH3)CH2SCH3 ch3 Et Ph-3,4-Cl2 Η CH (CH3)CH2SCH3 ch3 n-Pr Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 i-Pr Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 c-Pr H Η CH (CH3)CH2SCH3 ch3 c - Pr Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 n-Bu Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 s-Bu Ph-4-C1 Η CH (CH3)CH2SCH3 ch3 i-Bu Ph_4-Cl Η CH (CH3)CH2SCH3 ch3 c-Bu H Η CH (CH3)CH2SCH3 ch3 c - Bu Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 n-Pen Ph-4-Cl Η ch(ch3)ch2sch3 ch3 c~Pen H Η CH (CH3)CH2SCH3 ch3 c-Pen Ph-4-Cl Η CH(CH3)CH2SCH3 ch3 n - Hex Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 c-Hex H Η CH (CH3)CH2SCH3 ch3 c-Hex Ph-4-Cl . Η CH (CH3)CH2SCH3 ch3 CH2F Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 ch2ci Ph-4-C1 Η CH (CH3)CH2SCH3 ch3 CH2Br Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 chf2 Ph-4-F Η CH (CH3)CH2SCH3 ch3 chf2 Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 chf2 Ph-4-Br Η CH (CH3)CH2SCH3 ch3 chf2 Ph-4-CF3 Η CH (CH3)CH2SCH3 ch3 chf2 Ph-4-0CHF2 Η CH (CH3)CH2SCH3 ch3 chf2 Ph-4-0CF3 Η CH (CH3)CH2SCH3 ch3 chf2 Ph-3, 4-Cl2 Η CH (CH3)CH2SCH3 ch3 cf3 Ph Η CH (CH3)CH2SCH3 ch3 cf3 Ph-4-F Η CH (CH3)CH2SCH3 ch3 cf3 Ph_4-Cl Η CH (CH3)CH2SCH3 ch3 cf3 Ph-4-Br Η CH (CH3)CH2SCH3 ch3 cf3 Ph-4-I Η CH (CH3)CH2SCH3 ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-4-C (CF3)2〇H Η CH (CH3)CH2SCH3 ch3 cf3 Ph-4-0CHF2 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-4-0CF3
4]8 314918 200407073 Η CH (CH3)CH2SCH3 ch3 cf3 Ph~4-0CF2Br Η CH (CH3)CH2SCH3 ch3 cf3 Ph-4-0CF2CHF2 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-4-0CF2CHFCl Η CH (CH3)CH2SCH3 ch3 cf3 Ph-4_0CF2CHFCF3 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-4-0CF2CHF0CF3 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-4-OCF2CHFOCF2CF Η CH (CH3)CH2SCH3 ch3 cf3 Ph - 3,4-F2 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3_F_4-C1 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3, 4-Cl2 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3-F-4-CF3 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3-F-4-0CHF2 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3-C!-4-0CHF2 * Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3-F-4-OCF 3 Η CH (CH3)CH2SCH3 ch3 cf3 Ph-3_Cl-4-0CF3 Η CH (CH3)CH2SCH3 ch3 cf3 Ph (-3-0CF2 0-4-) Η CH (CH3)CH2SCH3 ch3 cf3 Ph (-3-0CF2CF2 0-4-) Η CH (CH3)CH2SCH3 ch3 cf3 2-Naph Η CH (CH3)CH2SCH3 ch3 cf3 L-lb Η CH (CH3)CH2SCH3 ch3 cf3 L - 1c Η CH (CH3)CH2SCH3 ch3 cf3 L-ld Η CH (CH3)CH2SCH3 ch3 cf3 L - le Η CH (CH3)CH2SCH3 ch3 cf3 L_li Η CH (CH3)CH2SCH3 ch3 cf3 L-2b Η CH (CH3)CH2SCH3 ch3 cf3 L-3c Η CH (CH3)CH2SCH3 ch3 cf3 L_3d Η CH (CH3)CH2SCH3 ch3 cf3 L - 3e Η CH (CH3)CH2SCH3 ch3 cf3 L-3i Η CH (CH3)CH2SCH3 ch3 cf3 L-3j Η CH (CH3)CH2SCH3 ch3 cf3 L-3k Η CH (CH3)CH2SCH3 ch3 cf3 L-31 Η CH (CH3)CH2SCH3 ch3 cf3 L-3o Η CH (CH3)CH2SCH3 ch3 cf3 L-4b Η CH (CH3)CH2SCH3 ch3 cf3 L - 4c Η CH (CH3)CH2SCH3 ch3 cf3 L - 4e Η CH (CH3)CH2SCH3 ch3 cf3 L - 10b Η CH (CH3)CH2SCH3 ch3 cf3 L-lOc Η CH (CH3)CH2SCH3 ch3 cf3 L - 16a CF3 419 314918 200407073 Η CH (CH3)CH2SCH3 ch3 cf3 L- 16b Η CH (CH3)CH2SCH3 ch3 cf3 L - 17a Η CH (CH3)CH2SCH3 ch3 cf3 L~21b Η CH (CH3)CH2SCH3 ch3 cf3 L - 21c Η CH (CH3)CH2SCH3 ch3 cf3 L-21e Η CH (CH3)CH2SCH3 ch3 cf3 L - 22b Η CH (CH3)CH2SCH3 ch3 cf3 L - 22c Η CH (CH3)CH2SCH3 ch3 cf3 L-23b Η CH (CH3)CH2SCH3 ch3 cf3 L - 23c Η CH (CH3)CH2SCH3 ch3 cf3 L-23f Η CH (CH3)CH2SCH3 ch3 cf3 L - 23g Η CH (CH3)CH2SCH3 ch3 cf3 L-31a Η CH (CH3)CH2SCH3 ch3 cf3 L-31b Η CH (CH3)CH2SCH3 ch3 cf3 L-45c Η CH (CH3)CH2SCH3 ch3 cf3 L - 45d Η CH (CH3)CH2SCH3 ch3 cf3 L - 45e Η CH (CH3)CH2SCH3 ch3 CF? L - 45i Η CH (CH3)CH2SCH3 ch3 CF; L-45g Η CH (CH3)CH2SCH3 ch3 cf3 L - 45m Η CH (CH3)CH2SCH3 ch3 cf3 L-46c Η CH (CH3)CH2SCH3 ch3 cf3 L - 46d Η CH (CH3)CH2SCH3 ch3 cf3 L-46e Η CH (CH3)CH2SCH3 ch3 cf3 L-46f Η CH (CH3)CH2SCH3 ch3 cf3 L-46g Η CH (CH3)CH2SCH3 ch3 cf3 L - 46j Η CH (CH3)CH2SCH3 ch3 cf3 L-46k Η CH (CH3)CH2SCH3 ch3 cf3 L-46r Η CH (CH3)CH2SCH3 ch3 cf3 L - 47a Η CH (CH3)CH2SCH3 ch3 cf3 L - 50b Η CH (CH3)CH2SCH3 ch3 cf3 L-50c Η CH (CH3)CH2SCH3 ch3 cf3 L-51b Η CH (CH3)CH2SCH3 ch3 cf2ci Ph~4~F Η CH (CH3)CH2SCH3 ch3 cf2ci Ph+Cl Η CH (CH3)CH2SCH3 ch3 cf2ci Ph_4-Br Η CH (CH3)CH2SCH3 ch3 cf2ci Ph-4-CF3 Η CH (CH3)CH2SCH3 ch3 cf2ci Ph-4-0CHF Η CH(CH3)CH2SCH3 ch3 cf2ci Ph-4-0CF3
420 314918 200407073 Η ch(ch3)ch2sch3 ch3 cf2ci Ph-3,4-Cl Η ch(ch3)ch2sch3 ch3 CF2Br Ph-4_F Η ch(ch3)ch2sch3 ch3 CF2Br Ph-4-Cl Η ch(ch3)ch2sch3 ch3 CF2Br Ph-4-0CHF Η ch(ch3)ch2sch3 ch3 CF2CHF2 Ph-4-F Η CH (CH3)CH2SCH3 ch3 cf2chf2 Ph-4-C1 Η CH (CH3)CH2SCH3 ch3 cf2chf2 Ph-4-0CHF Η CH (CH3)CH2SCH3 ch3 cf2cf3 Ph-4-F Η CH (CH3)CH2SCH3 ch3 cf2cf3 Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 cf2cf3 Ph-4-Br Η CH (CH3)CH2SCH3 CHa cf2cf3 Ph-4-CF3 Η CH (CH3)CH2SCH3 ch3 cf2cf3 Ph-4-0CHF Η CH (CH3)CH2SCH3 ch3 cf2cf3 Ph-4-0CF3 Η CH (CH3)CH2SCH3 ch3 cf2cf3 Ph-3, 4-Cl Η CH (CH3)CH2SCH3 ch3 cf2cf2ci Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 CFCICFa Ph-4-C1 Η CH (CH3)CH2SCH3 ch3 CFC1CF2C1 Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 CF2CF2Br Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 CFBrCF3 Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 CF2CF2CF3 Ph+Cl Η CH (CH3)CH2SCH3 ch3 cf(cf3)2 Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 cf2cfcicf2ci Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 T-l H Η CH (CH3)CH2SCH3 ch3 T-2 H Η CH (CH3)CH2SCH3 ch3 T-3 H Η CH (CH3)CH2SCH3 ch3 T-4 H Η CH (CH3)CH2SCH3 ch3 T-5 H Η CH (CH3)CH2SCH3 ch3 CF2CF2CF2CF3 Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 cf2cf2cf2chf2 Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 CF (CF3)CF2CF3 Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 cf2cf2cf2cf2ci Ph+Cl Η CH (CH3)CH2SCH3 ch3 CF2CF2CF2CF2CF2CF3 Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 ch2och3 H Η CH (CH3)CH2SCH3 ch3 ch2och3 ch3 Η CH (CH3)CH2SCH3 ch3 ch2och3 Et Η CH (CH3)CH2SCH3 ch3 ch2och3 n-Pr Η CH (CH3)CH2SCH3 ch3 ch2och3 i-Pr
421 314918 200407073
Η CH (CH3)CH2SCH3 ch3 ch2och3 Pli - 4-F Η ch(ch3)ch2sch3 ch3 ch2och3 Ph+Cl Η CH(CH3)CH2SCH3 ch3 ch2och3 Ph-4-Br Η CH (CH3)CH2SCH3 ch3 ch2och3 Ph-4-CF3 Η CH (CH3)CH2SCH3 ch3 ch2och3 Ph-4-0CHF Η CH (CH3)CH2SCH3 ch3 ch2och3 Ph-4-0CF3 Η CH (CH3)CH2SCH3 ch3 CH20Et H Η CH (CH3)CH2SCH3 ch3 CH20Et Ph-4-F Η CH (CH3)CH2SCH3 ch3 CH20Et Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 CH20Et Ph-4-Br Η CH (CH3)CH2SCH3 ch3 CH20Et Ph-4-CF3 Η CH (CH3)CH2SCH3 ch3 CH20Et Ph-4-0CHF Η CH (CH3)CH2SCH3 ch3 CH20Et Ph-4-0CF3 Η CH (CH3)CH2SCH3 ch3 ch2och2cf3 H Η CH (CH3)CH2SCH3 ch3 ch2och2cf3 ch3 Η CH (CH3)CH2SCH3 ch3 ch2och2cf3 Et Η CH(CH3)CH2SCH3 ch3 ch2och2cf3 n-Pr Η CH(CH3)CH2SCH3 ch3 ch2och2cf3 i - Pr Η CH (CH3)CH2SCH3 ch3 ch2och2cf3 Ph~4~F Η CH (CH3)CH2SCH3 ch3 ch2och2cf3 Ph-4-C1 Η CH(CH3)CH2SCH3 ch3 ch2och2cf3 Ph+Br Η CH (CH3)CH2SCH3 ch3 ch2och2cf3 Ph-4-CF3 Η CH (CH3)CH2SCH3 ch3 ch2och2cf3 Ph-4-0CHF； Η CH(CH3)CH2SCH3 ch3 ch2och2cf3 Ph-4-0CF3 Η CH(CH3)CH2SCH3 ch3 ch2och2cf2cf3 H Η CH (CH3)CH2SCH3 ch3 ch2och2cf2cf3 ch3 Η CH (CH3)CH2SCH3 ch3 ch2och2cf2cf3 Et Η CH (CH3)CH2SCH3 ch3 ch2och2cf2cf3 n-Pr Η CH (CH3)CH2SCH3 ch3 ch2och2cf2cf3 i-Pr Η CH (CH3)CH2SCH3 ch3 ch2och2cf2cf3 Ph-4-F Η CH (CH3)CH2SCH3 ch3 ch2och2cf2cf3. Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 ch2och2cf2cf3 Ph-4-Br Η CH (CH3)CH2SCH3 ch3 ch2och2cf2cf3 Ph-4-CF3 Η CH (CH3)CH2SCH3 ch3 ch2och2cf2cf3 Ph-4_0CHF: Η CH (CH3)CH2SCH3 ch3 ch2och2cf2cf3 Ph-4-0CF3 Η CH (CH3)CH2SCH3 ch3 cf2ocf2cf2ocf3 H Η CH (CH3)CH2SCH3 ch3 CF (CF3)〇CF2CF2CF3 H
422 314918 200407073
Η CH (CH3)CH2SCH3 ch3 ch2sch3 H Η CH(CH3)CH2SCH3 ch3 ch2sch3 Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 ch2sch3 Ph-4-OCFa Η CH (CH3)CH2SCH3 ch3 ch2so2ch3 H Η CH (CH3)CH2SCH3 ch3 ch2so2ch3 Ph-4-C1 Η CH (CH3)CH2SCH3 ch3 ch2so2ch3 Pli-4-0CF3 Η CH (CH3)CH2SCH3 ch3 CH2SEt H Η CH (CH3)CH2SCH3 ch3 CH2SEt Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 CH2SEt Ph-4-0CF3 Η CH (CH3)CH2SCH3 ch3 ch2scf3 H Η CH (CH3)CH2SCH3 ch3 ch2scf3 Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 ch2scf3 Ph-4-0CF3 Η CH (CH3)CH2SCH3 ch3 CH2SPh H Η CH(CH3)CH2SCH3 ch3 CH2SPh Ph-4，C1 Η CH (CH3)CH2SCH3 ch3 och3 H Η CH (CH3)CH2SCH3 ch3 och3 ch3 Η CH (CH3)CH2SCH3 ch3 och3 Et Η CH (CH3)CH2SCH3 ch3 och3 n - Pr Η CH (CH3)CH2SCH3 ch3 och3 i - Pr Η CH (CH3)CH2SCH3 ch3 och3 Ph-4-F Η CH (CH3)CH2SCH3 ch3 och3 Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 och3 Ph-4-Br Η CH (CH3)CH2SCH3 ch3 och3 Ph-4-CF3 Η CH (CH3)CH2SCH3 ch3 och3 Ph-4-OCHF Η CH (CH3)CH2SCH3 ch3 och3 Ph-4-0CF3 Η CH (CH3)CH2SCH3 ch3 so2cf3 H Η CH (CH3)CH2SCH3 ch3 so2cf3 ch3 Η CH (CH3)CH2SCH3 ch3 so2cf3 Et Η CH (CH3)CH2SCH3 ch3 so2cf3 n - Pr Η CH (CH3)CH2SCH3 ch3 so2cf3 i-Pr Η CH (CH3)CH2SCH3 ch3 so2cf3 Ph~4*~F Η CH (CH3)CH2SCH3 ch3 SO 2 CF 3 Ph-4-Cl Η CH (CH3)CH2SCH3 ch3 S02CF3 Ph+Br Η CH (CH3)CH2SCH3 ch3 SO 2 CF 3 Ph-4-CF3 Η CH (CH3)CH2SCH3 ch3 so2cf3 Ph-4-OCHF Η CH (CH3)CH2SCH3 ch3 so2cf3 Ph+0CF3 Η CH (CH3)CH2SCH3 ch3 SPh H
423 314918 200407073
Η CH (CH3)CH2SCH3 ch3 SPh ch3 Η ch(ch3)ch2sch3 ch3 SPh Et Η CH (CH3)CH2SCH3 ch3 SPh n-Pr Η CH (CH3)CH2SCH3 ch3 SPh i-Pr Η CH (CH3)CH2SCH3 ch3 SPh Ph+Cl Η CH (CH3)CH2SCH3 ch3 T-22 H Η CH (CH3)CH2SCH3 ch3 T-23 H Η CH (CH3)CH2SCH3 ch3 T-24 H Η CH (CH3)CH2SCH3 ch3 Ph H Η CH (CH3)CH2SCH3 ch3 Ph-4-F H Η CH (CH3)CH2SCH3 ch3 Ph-4-Cl H Η CH (CH3)CH2SCH3 ch3 Ph~4~Br H Η CH (CH3)CH2SCH3 ch3 Ph-4-I H Η CH (CH3)CH2SCH3 ch3 Ph-4-CH3 H Η CH (CH3)CH2SCH3 ch3 Ph~4~Bu-t H Η . CH (CH3)CH2SCH3 ch3 Ph_4-CF3 H Η CH (CH3)CH2SCH3 ch3 Ph-4-CH20CH2CF3 H Η CH(CH3)CH2SCH3 ch3 Ph-4-C (CF3) 2〇H H Η CH (CH3)CH2SCH3 ch3 Ph+CH2SCH3 H Η CH (CH3)CH2SCH3 ch3 Ph+CH2S(0&gt;CH3 H Η CH (CH3)CH2SCH3 ch3 Ph-4-CH2S02CH3 H Η CH (CH3)CH2SCH3 ch3 Ph-4-CH2SCF3 H Η CH (CH3)CH2SCH3 ch3 PH - CH2S(0)CF3 H Η CH (CH3)CH2SCH3 ch3 Ph-4 - CH2S02CF3 H Η CH (CH3)CH2SCH3 ch3 Ph-4-0CH3 H Η CH (CH3)CH2SCH3 ch3 Ph-4-OPr-i H Η CH (CH3)CH2SCH3 ch3 Ph-4-0CHF2 H Η CH (CH3)CH2SCH3 ch3 Ph+OCF3 H Η CH (CH3)CH2SCH3(R) ch3 Ph-4-0CF3 H Η CH (CH3)CH2SCH3(S) ch3 Ph-4-0CF3 H Η CH (CH3)CH2SCH3 ch3 Ph-4-0CF2Br H Η CH (CH3)CH2SCH3 ch3 Ph-4-0CH2CF3 H Η CH (CH3)CH2SCH3 ch3 Ph~4-0CF2CHF2 H Η CH (CH3)CH2SCH3 ch3 Ph-4-0CF2CHFCl H Η CH (CH3)CH2SCH3 ch3 Ph-4-0CF2CHFBr H Η CH (CH3)CH2SCH3 ch3 Ph-4-0CF2CF2Br H Η CH (CH3)CH2SCH3 ch3 Ph-4OCF2CFC12 H
424 314918 200407073
Η CH (CH3)CH2SCH3 ch3 Ph-4-0CF2CCl3 H Η CH (CH3)CH2SCH3 ch3 Ph-4~0CH2CF2CHF2 H Η CH (CH3)CH2SCH3 ch3 Ph«4-0CF2CHFCF3 H Η CH (CH3)CH2SCH3 ch3 Ph~4-0CH (CF3)2 H Η CH (CH3)CH2SCH3 ch3 Ph-4-0CF2CFBrCF3 H Η CH (CH3)CH2SCH3 ch3 Ph-4-0CF2CHF0CF3 H Η CH (CH3)CH2SCH3 ch3 Ph-4_0CF2CHF0CF2CF2CF3 H Η CH (CH3)CH2SCH3 ch3 Ph-4-0S02CH3 H Η CH (CH3)CH2SCH3 ch3 Ph-4-0S02CF3 H Η CH (CH3)CH2SCH3 ch3 Ph-4-0 (Ph-4-CF3) H Η CH (CH3)CH2SCH3 ch3 Ph-3-0 (L-45g) H Η CH (CH3)CH2SCH3 ch3 Ph-4 - 0 (L - 45g&gt; H Η CH (CH3) CH2SCH3 ch3 Ph-4-0(L-451) H Η CH (CH3)CH2SCH3 ch3 Ph-4-SCH3 H Η CH (CH3)CH2SCH3 ch3 Ph-4-S (0) CH3 H Η CH (CH3)CH2SCH3 ch3 Ph-4-S02CH3 H Η CH (CH3)CH2SCH3 ch3 Ph-4-SCFa H Η CH (CH3)CH2SCH3 ch3 Ph~4~S (0) CF3 H Η CH (CH3)CH2SCH3 ch3 Ph~4-S02CF3 H Η CH (CH3)CH2SCH3 ch3 Ph-4-N02 H Η CH (CH3)CH2SCH3 ch3 Ph-4-N (CH3) 2 H Η CH (CH3)CH2SCH3 ch3 Ph-4 - CN. H Η CH (CH3)CH2SCH3 ch3 Ph-4-C (0) NH2 H Η CH (CH3)CH2SCH3 ch3 Pb - 4-C(S)NH2 H Η CH (CH3)CH2SCH3 ch3 Ph-3, 4-F2 H Η CH (CH3)CH2SCH3 ch3 Ph-3-F-4-Cl H Η CH (CH3)CH2SCH3 ch3 Ph-3, 4-Cl2 H Η CH (CH3)CH2SCH3 ch3 Ph-3-F-4-CF3 H Η CH (CH3)CH2SCH3 ch3 Ph-3~F-4-0CHF2 H Η CH (CH3)CH2SCH3 ch3 Ph-3-Cl-4-0CHF2 H Η CH (CH3)CH2SCH3 ch3 Ph-3~F-4~0CF 3 H Η CH(CH3)CH2SCH3 ch3 Ph-3&gt;Cl-4-0CF3 H Η CH (CH3)CH2SCH3 ch3 Ph~3~F~4~0CF 2 B r H Η CH (CH3)CH2SCH3 ch3 2-Naph H Η CH (CH3)CH2SCH3 ch3 L-lb H Η CH (CH3)CH2SCH3 ch3 L-lc H Η CH (CH3)CH2SCH3 CHa L-ld H
425 314918 200407073
Η CH (CH3)CH2SCH3 ch3 L - le H Η CH (CH3)CH2SCH3 ch3 L-li H Η CH (CH3)CH2SCH3 ch3 L-2b H Η CH (CH3)CH2SCH3 ch3 L-3c H Η CH (CH3)CH2SCH3 ch3 L-3d H Η CH (CH3)CH2SCH3 ch3 L - 3e H Η CH (CH3)CH2SCH3 ch3 L - 3i H Η CH (CH3)CH2SCH3 ch3 L - 3j H Η CH (CH3)CH2SCH3 ch3 L-3k H Η CH (CH3)CH2SCH3 ch3 L-31 H Η CH(CH3)CH2SCH3 ch3 L-4b H Η CH (CH3)CH2SCH3 ch3 L - 4c H Η CH (CH3)CH2SCH3 ch3 L-6d H Η CH(CH3)CH2SCH3 ch3 L-6e H Η CH (CH3)CH2SCH3 ch3 L-lOb H Η CH(CH3)CH2SCH3 ch3 L-lOc H Η CH (CH3)CH2SCH3 ch3 L-16a H Η CH (CH3)CH2SCH3 ch3 L- 16b H Η CH (CH3)CH2SCH3 ch3 L-17a H Η CH(CH3)CH2SCH3 ch3 L - 21b H Η CH(CH3)CH2SCH3 ch3 L - 21c H Η CH(CH3)CH2SCH3 ch3 L-21d H Η CH (CH3)CH2SCH3 ch3 卜21e H Η CH(CH3)CH2SCH3 ch3 L - 22b H Η CH(CH3)CH2SCH3 ch3 L-22c H Η CH (CH3)CH2SCH3 ch3 L-23b H Η CH (CH3)CH2SCH3 ch3 L-23c H Η CH (CH3)CH2SCH3 ch3 L-23f H Η CH (CH3)CH2SCH3 ch3 L-23g H Η CH (CH3)CH2SCH3 ch3 L~31a H Η CH(CH3)CH2SCH3 ch3 L-31b H Η CH (CH3)CH2SCH3 ch3 L-45d H Η CH (CH3)CH2SCH3 ch3 L~45e H Η CH (CH3)CH2SCH3 ch3 L-45i H Η CH (CH3)CH2SCH3 ch3 L - 45g H Η CH (CH3)CH2SCH3 ch3 L-45in H Η CH (CH3)CH2SCH3 ch3 L - 46d H
426 314918 200407073
Η CH (CH3)CH2SCH3 ch3 L - 46e H Η CH (CH3)CH2SCH3 ch3 L-46i H Η CH (CH3)CH2SCH3 ch3 L-46g H Η CH (CH3)CH2SCH3 ch3 L - 46j H Η CH (CH3)CH2SCH3 ch3 L - 46k H Η CH (CH3)CH2SCH3 ch3 L，46q H Η CH (CH3)CH2SCH3 ch3 L-46r H Η CH (CH3)CH2SCH3 ch3 L - 47a H Η CH (CH3)CH2SCH3 ch3 L - 47e H Η CH (CH3)CH2SCH3 ch3 L-50b H Η CH (CH3)CH2SCH3 ch3 卜50c H Η CH (CH3)CH2SCH3 ch3 L-50d H Η CH (CH3)CH2SCH3 ch3 L-51b H Η CH (CH3)CH2SCH3 Et cf3 Ph+Cl Η CH (CH3)CH2SCH3 Et Ph-4-OCFa H Η CH(CH3)CH2SCH3 ch2oh cf3 Ph+Cl Η CH (CH3) CH2SCH3 ch2oh Ph+0CF3 H Η CH (CH3)CH2SCH3 och3 cf3 Ph-4-Cl Η CH(CH3)CH2SCH3 och3 Ph-4-OCF 3 H Η CH(CH3)CH2SCH3 sch3 cf3 Ph_4-Cl Η CH(CH3)CH2SCH3 sch3 Ph-4-0CF3 H Η CH (CH3)CH2S(0) CH3 F cf3 Ph-4-Cl Η CH (CH3)CH2S(0) CH3 F Ph-4-OCFa H Η CH (CH3)CH2S(0) CH3 Cl cf3 Ph-4-F Η CH (CH3)CH2S(0) CH3 Cl cf3 Ph+Cl Η CH(CH3)CH2S(0) ch3 Cl cf3 Ph-4-Br Η CH (CH3)CH2S(0) CH3 Cl cf3 Ph+CF3 Η CH (CH3)CH2S(0)CH3 Cl cf3 Ph-4-0CHF2 Η CH(CH3)CH2S(0)CH3 Cl cf3 Ph-4-0CF3 Η CH (CH3)CH2S(0) CH3 Cl cf3 Ph-3, 4-Cl2 Η CH (CH3)CH2S (0) CH3 Cl Ph~4~F H Η CH(CH3)CH2S(0) ch3 Cl Ph+Cl H Η CH (CH3)CH2S(0)CH3 Cl Ph-4-Br H Η CH (CH3)CH2S(0) CH3 Cl Ph-4-CF 3 H Η ch(ch3)ch2s_3 Cl Ph-4-0CHF2 H Η CH (CH3)CH2S(0) CH3 Cl Ph-4-0CF3 H Η CH (CH3)CH2S(0) CH3 Cl Ph - 4-0 (L-45g) H
427 314918 200407073 Η CH (CH3)CH2S(0) CH3 Cl Ph-3,4-Cl2 H Η CH (CH3)CH2S(0) CH3 Br cf3 Ph-4-Cl Η CH (CH3)CH2S(0) CH3 Br Ph-4-OCF 3 H Η CH (CH3)CH2S(0) CH3 ch3 F Ph-4-F Η CH (CH3)CH2S(0) CH3 ch3 F Ph-4-Cl Η CH (CH3)CH2S(0) CH3 ch3 F Ph-4-Br Η CH (CH3)CH2S(0) CH3 ch3 F Ph-4-CF3 Η CH (CH3)CH2S(0) CH3 ch3 F Ph-4-0CHF2 Η CH (CH3)CH2S(0)CH3 ch3 F Ph-4-0CF3 Η CH(CH3)CH2S(0) ch3 ch3 F Ph-3,4-Cl2 Η ch(ch3&gt;chw〇)ch3 ch3 Cl Ph-4~F Η CH (CH3)CH2S(0)CH3 ch3 Cl Ph-4-Cl Η CH (CH3)CH2S(0) CH3 ch3 Cl Ph-4，Br Η CH (CH3)CH2S(0) CH3 ch3 Cl Ph-4-I Η CH (CH3)CH2S(0) CH3 ch3 Cl Ph-4-CF3 Η CH (CH3)CH2S(0) CH3 ch3 Cl Ph-4-0CHF2 Η CH(CH3)CH2S(0)CH3 ch3 Cl Ph-4-OCF3 Η CH (CH3)CH2S(0) CH3 ch3 Cl Ph-4-0CF2Br Η ch(ch3&gt;chw〇&gt;ch3 ch3 Cl Ph-4-0CF2CHF2 Η CH (CH3)CH2S(0) CH3 ch3 Cl Ph-4-0CF2CHFCl Η ch(ch3&gt;chw〇)ch3 ch3 Cl Ph-4-0CF2CHFCF3 Η CH(CH3)CH2S(0) ch3 ch3 Cl Ph-4-0CF2CHF0CF Η CH (CH3)CH2S{〇) CH3 ch3 Cl Ph-4-0 (L-45g) Η CH(CH3)CH2S(0) ch3 ch3 Cl Ph-3, 4-Cl2 Η CH(CH3)CH2S(0) ch3 ch3 Br Ph-4-F Η CH(CH3)CH2S(0) ch3 ch3 Br Ph-4-Cl Η CH(CH3)CH2S(0) ch3 ch3 Br Ph-4-Br Η CH (CH3)CH2S(0) CH3 ch3 Br Ph+CF3 Η CH (CH3)CH2S(0) CH3 ch3 Br Ph-4-0CHF2 Η CH(CH3)CH2S(0) ch3 ch3 Br Ph-4-0CF3 Η CH (CH3)CH2S(0) CH3 ch3 Br Ph-3,4-Cl2 Η ch(ch3)chw〇)ch3 ch3 ch3 Ph-4-F Η CH(CH3)CH2S(0)CH3 ch3 ch3 Ph+Cl Η ch(ch3)ch2s®ch3 ch3 ch3 Ph-4-Br Η ch(ch3)ch2s_3 ch3 ch3 Ph-4-CF3 Η CH (CH3)CH2S(0) CH3 ch3 ch3 Ph-4-0CHF2 Η CH (CH3)CH2S(0) CH3 ch3 ch3 Ph-4-0CF3
428 314918 200407073 Η CH (CH3)CH2S(0) CH3 ch3 ch3 Ph-4-0CF2Br Η □1(013)0125似013 ch3 ch3 Ph~4-0CF2CHFCF3 Η CH (CH3)CH2S(0) CH3 ch3 ch3 Ph-3, 4-F2 Η CH (CH3)CH2S(0) CH3 ch3 ch3 Ph~3-F~4~C1 Η CH (CH3)CH2S(0) CH3 ch3 ch3 Ph-3, 4-Cl2 Η CH (CH3)CH2S(0) CH3 ch3 ch3 L - 46d Η CH (CH3)CH2S(0) CH3 ch3 Et Ph-4-F Η CH (CH3)CH2S(0) CH3 ch3 Et PH-Cl Η CH (CH3)CH2S(0) CH3 ch3 Et Ph+Br Η CH(CH3)CH2S(0) ch3 ch3 Et Ph-4-CF3 Η CH(CH3)CH2S«))CH3 ch3 Et Ph-4-0CHF2 Η CH (CH3)CH2S(0) CH3 ch3 Et Ph-4-0CF3 Η CH (CH3)CH2S(0)CH3 ch3 Et Ph-3, 4~C12 Η CH(CH3&gt;CH2S«))CH3 ch3 c - Pr H Η ch(ch3)ch2s(o)ch3 ch3 chf2 Ph-4-F Η CH(CH3)CH2S(0) ch3 ch3 chf2 Ph-4-Cl Η CH(CH3)CH2S(0) ch3 ch3 chf2 Ph~4~Br Η CH(CH3)CH2S(0)CH3 ch3 chf2 Ph-4-CF3 Η CH (CH3)CH2S(0) CH3 ch3 chf2 Ph-4-0CHF2 Η CH(CH3)CH2S«))CH3 ch3 chf2 Ph-4-0CF3 Η CH(CH3)CH2S(0) ch3 ch3 chf2 Ph-3, 4-Cl2 Η CH(CH3)CH2S(0) ch3 ch3 cf3 Ph-4-F Η CH (CH3)CH2S(0)CH3 ch3 cf3 Ph-4-Cl Η CH(CH3)CH2S(0) ch3 ch3 cf3 Ph-4-Br Η ch(ch3)ch2s(o)ch3 ch3 cf3 Ph-4-I Η ch(ch3)ch2s_3 ch3 cf3 Ph+CF3 Η CH (CH3)CH2S(0) CH3 ch3 cf3 Ph-4-0CHF2 Η CH(CH3)CH2S(0) ch3 ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2S(0)CH3 ch3 cf3 Ph-4-0CF2Br Η CH(CH3)CH2S(0) ch3 ch3 cf3 Ph-4-0CF2CHF2 Η CH (CH3)CH2S(0) CH3 ch3 cf3 Ph-4-0CF2CHFCl Η CH (CH3)CH2S(0) CH3 ch3 cf3 Ph-4-0CF2CHFCF3 Η ch(ch3)chw〇kh3 ch3 cf3 Ph-4_0CF2CHF0CF3 Η CH (CH3)CH2S(0) CH3 ch3 cf3 Ph-4-0CF2CHF0CF2CF2CF Η CH (CH3)CH2S(0) CH3 ch3 cf3 Ph-3, 4-F2 Η CH (CH3)CH2S(0) CH3 ch3 cf3 Ph-3-F-4-Cl Η CH (CH3)CH2S(0)CH3 ch3 cf3 Ph-3, 4-Cl2 429 314918 200407073
Η ch(ch3)ch2s(o)ch3 ch3 cf2ci Ph-4-F Η ch(ch3)ch2s(o)ch3 ch3 cf2ci Ph-4-Cl Η CH (CH3)CH2S(0) CH3 ch3 cf2ci Ph，4-Br Η CH (CH3)CH2S(0) CH3 ch3 cf2ci Ph-4-CF3 Η ch(ch3)ch2s_3 ch3 cf2ci Ph-4-0CHF2 Η CH (CH3)CH2S(0) CH3 ch3 cf2ci Ph-4-0CF3 Η CH (CH3)CH2S(0) CH3 ch3 cf2ci Ph-3, 4-Cl2 Η CH (CH3)CH2S(0) CH3 ch3 CF2Br Ph-4-Cl Η CH (CH3)CH2S(0) CH3 ch3 cf2cf3 Ph-4-F Η CH (CH3)CH2S(0) CH3 ch3 cf2cf3 Ph-4-Cl Η CH (CH3)CH2S(0) CH3 ch3 cf2cf3 PH-Br Η ch(ch3)ch^o)ch3 ch3 cf2cf3 Ph-4-CF3 Η CH(CH3&gt;CH2S«)&gt;CH3 ch3 cf2cf3 Ph-4-0CHF2 Η CH (CH3)CH2S(0)CH3 ch3 cf2cf3 Ph-4-0CF3 Η CH(CH3)CH2S(0) ch3 ch3 cf2cf3 Ph-3,4-Cl2 Η CHOJCHWOKHs ch3 cf2cf2cf3 Ph+Cl Η CH (CH3)CH2S(0) CH3 ch3 ch2och2cf3 H Η CH(CH3)CH2S(0) ch3 ch3 ch2och2cf3 ch3 Η CH(CH3)CH2S«))CH3 ch3 ch2och2cf3 Et Η CH(CH3)CH2S(0) ch3 ch3 ch2och2cf3 n-Pr Η CH(CH3)CH2S(0) ch3 ch3 ch2och2cf3 i-Pr Η CH (CH3)CH2S(0) CH3 ch3 ch2och2cf3 Ph-4-Cl Η CH (CH3)CH2S(0)CH3 ch3 ch2och2cf2cf3 H Η CH (CH3)CH2S(0) CH3 ch3 ch2och2cf2cf3 ch3 Η CH (CH3)CH2S(0) CH3 ch3 ch2och2cf2cf3 Ph-4-Cl Η CH (CH3)CH2S(0) CH3 ch3 cf2ocf2cf2ocf3 H Η CH (CH3)CH2S(0) CH3 ch3 CF (CF3)〇CF2CF2CF3 H Η CH (CH3)CH2S(0) CH3 ch3 ch2scf3 H Η CH (CH3)CH2S(0) CH3 ch3 ch2scf3 Ph-4-Cl Η CH (CH3)CH2S(0) CH3 ch3 S02CF3 H Η CH(CH3)CH2S(0) ch3 ch3 T - 22 H Η CH (CH3)CH2S(0) CH3 ch3 T-23 H Η CHOjCHWOKl^ ch3 T-24 H Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-F H Η CH(CH3)CH2S(0) ch3 ch3 Ph+Cl H Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-Br H Η CH(CH3)CH2S«))CH3 ch3 Ph-4-I H
430 314918 200407073 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0)CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH{CH3)CH2S(0) ch3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0)CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0)CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H ch(ch3)ch2swch3 ch3 H CH(CH3)CH2S(0) ch3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH(CH3)CH2S(0)CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H ch(ch3)chw〇)ch3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH(CH3)CH2S(0) ch3 ch3 H ch(ch3)ch2s_3 ch3 H CH(CH3)CH2S(0) ch3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0)CH3 ch3 H CH (CH3)CH2S(0) CH3 ch3 H CH (CH3)CH2S(0)CH3 ch3
Ph+CF3 Η
Ph-4-0CHF2 Η
Ph-4-0CF3 Η
Ph~4-0CF2Br Η
Ph-4-0CF2CHF2 Η
Ph-4-0CF2CHFCl Η
Ph-4~0CF2CHFCF3 Η
Ph~4-0CF2CHF0CF3 Η
Ph-4-0CF2CHF0CF2CF2CF3 Η Ph-4-0 (Ph-4-CF3) H
Ph-4-0 (L - 45g) H
Ph-4-SCF3 H
Ph-4-CN H
Ph-4-C (0)NH2 H
Ph - 4-C ⑸ NH2 H
Ph-3,4-F2 H
Ph-3_F-4-C1 H
Ph-3,4-Cl2 H
L-lb H
L~lc H
L-ld H
L - le H
L-li H
L-2b H
L - 3b H
L - 3c H
L - 3d H
L - 3e H
L-3f H
L~3k H
L-31 H
L - 3o H
L-4b H
L-4c H
L-10b H
L-lOc H
L-16a H
431 314918 200407073 Η CH(CH3)CH2S(0)CH3 ch3 L- 16b H Η CH (CR3)CH2S(0) CH3 ch3 L-21b H Η ch(ch3)ch2s(o)ch3 ch3 L~21c H Η CH(CH3)CH2S«))CH3 ch3 L - 21d H Η ch(ch3)ch2s_3 ch3 L - 21e H Η CH (CH3)CH2S(0) CH3 ch3 L - 22b H Η CH (CH3)CH2S(0) CH3 ch3 L-22c H Η CH (CH3)CH2S(0) CH3 ch3 L-23b H Η ch(ch3)ch2s(o)ch3 ch3 L-23c H Η CH (CH3)CH2S(0) CH3 ch3 L~31a H Η CH (CH3)CH2S(0) CH3 ch3 L - 31b H Η CH (CH3)CH2S(0) CH3 ch3 L - 45c H Η ch(ch3)ch2s(o)ch3， ch3 L_45d H Η CH (CH3)CH2S(0) CH3 ch3 L~45e H Η CH (CH3)CH2S(0)CH3 ch3 L - 45i H Η CH (CH3)CH2S(0) CH3 ch3 L-45g H Η CH (CH3)CH2S(0) CH3 ch3 L-451 H Η CH (CH3)CH2S(0) CH3 ch3 L-45m H Η CH (CH3)CH2S(0)CH3 ch3 L-46c H Η CH (CH3)CH2S(0) CH3 ch3 L-46d H Η ch(ch3)chw〇)ch3 ch3 L-46e H Η CH (CH3)CH2S(0) CH3 ch3 L - 46f H Η CH(CH3)CH2S(0) ch3 ch3 L - 46g H Η ch(ch3)ch2s(o)ch3 ch3 L-46j H Η CH (CH3)CH2S(0) CH3 ch3 L-46k H Η CH (CH3)CH2S(0)CH3 ch3 L，46r H Η CH (CH3)CH2S(0) CH3 ch3 L-47a H Η CH (CH3)CH2S(0) CH3 ch3 L - 47e H Η CH(CH3)CH2S(0)CH3 ch3 L-50b H Η CH(CH3)CH2S(0) ch3 ch3 L-50c H Η CH (CH3)CH2S(0) CH3 ch3 L-50d H Η CH (CH3)CH2S(0) CH3 ch3 L-51b H Η CH(CH3)CH2S02CH3 F cf3 Ph-4-Cl Η CH(CH3)CH2S02CH3 F Ph-4-0CF3 H Η CH (CH3)CH2S02CH3 Cl cf3 Ph+F Η CH (CH3)CH2S02CH3 Cl cf3 Ph+Cl Η CH (CH3)CH2S02CH3 Cl cf3 Ph-4-Br
432 314918 200407073 Η CH (CH3)CH2S02CH3 Cl cf3 Ph-4-CF3 Η CH (CH3)CH2S02CH3 Cl cf3 Ph-4-0CHF2 Η CH (CH3)CH2S02CH3 Cl cf3 Ph-4-0CF3 Η CH (CH3)CH2S02CH3 Cl cf3 Ph - 3,4-Cl2 Η CH (CH3)CH2S02CH3 Cl Ph-4-F H Η CH (CH3)CH2S02CH3 Cl Ph-4-Cl H Η CH (CH3)CH2S02CH3 Cl Ph-4-Br H Η CH (CH3)CH2S02CH3 Cl Ph+CF3 H Η CH (CH3)CH2S02CH3 Cl Ph-4-0CHF2 H Η CH (CH3)CH2S02CH3 Cl Ph-4-0CF3 H Η CH (CH3)CH2S02CH3 Cl Ph-4 - 0 (L - 45g) H Η CH (CH3)CH2S02CH3 Cl Ph-3,4-Cl2 H Η CH (CH3)CH2S02CH3 Br cf3 Ph-4-C1 Η CH (CH3)CH2S02CH3 Br Ph-4-0CF3 H Η CH (CH3)CH2S02CH3 ch3 F Ph-4-F Η CH (CH3)CH2S02CH3 ch3 F PH-C1 Η CH (CH3)CH2S02CH3 ch3 F Ph-4~Br Η CH (CH3)CH2S02CH3 ch3 F Ph-4-CF3 Η CH (CH3)CH2S02CH3 ch3 F Ph-4-0CHF2 Η CH (CH3)CH2S02CH3 ch3 F Ph-4-0CF3 Η CH (CH3)CH2S02CH3 ch3 F Ph-3, 4-Cl2 Η CH (CH3)CH2S02CH3 ch3 Cl Ph~4~F Η CH (CH3)CH2S02CH3 ch3 Cl Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 Cl Ph-4-Br Η CH (CH3)CH2S02CH3 ch3 Cl Ph-4-I Η CH (CH3)CH2S02CH3 ch3 Cl Ph+CF3 Η CH (CH3)CH2S02CH3 ch3 Cl Ph-4-0CHF2 Η CH (CH3)CH2S02CH3 ch3 Cl Pb+0CF3 Η CH (CH3)CH2S02CH3 ch3 Cl Ph-4~0CF2Br Η CH (CH3)CH2S02CH3 ch3 Cl Ph-4-0CF2CHF2 Η CH (CH3)CH2S02CH3 ch3 Cl Ph-4-0CF2CHFCl Η CH (CH3)CH2S02CH3 ch3 Cl Ph-4-0CF2CHFCF3 Η CH (CH3)CH2S02CH3 ch3 Cl Ph-4-0CF2CHF0CF Η CH (CH3)CH2S02CH3 ch3 Cl Ph - 4-0(L-45g) Η CH (CH3)CH2S02CH3 ch3 Cl Ph_3, 4-Cl 2 Η CH (CH3)CH2S02CH3 ch3 Br Ph-4-F Η CH (CH3)CH2S02CH3 ch3 Br Ph-4-C!
433 314918 200407073 Η CH (CH3)CH2S02CH3 ch3 Br Ph+Br Η ch(ch3)ch2so2ch3 ch3 Br Ph+CF3 Η CH (CH3)CH2S02CH3 ch3 Br Ph-4-0CHF2 Η CH (CH3)CH2S02CH3 ch3 Br Ph-4-0CF3 Η CH (CH3)CH2S02CH3 ch3 Br Ph-3, 4~C12 Η CH (CH3)CH2S02CH3 ch3 ch3 Ph+F Η CH (CH3)CH2S02CH3 ch3 ch3 Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 ch3 PH-Br Η CH (CH3)CH2S02CH3 ch3 ch3 Ph-4-I Η CH (CH3)CH2S02CH3 ch3 ch3 Ph_4-CF3 Η CH (CH3)CH2S02CH3 ch3 ch3 Ph-4-0CHF2 Η CH (CH3)CH2S02CH3 ch3 ch3 Ph-4-0CF3 Η CH (CH3)CH2S02CH3 ch3 ch3 Ph-4-0CF2Br Η CH (CH3)CH2S02CH3 ch3 ch3 Ph-4-0CF2CHFCF Η CH (CH3)CH2S02CH3 ch3 ch3 Ph-3, 4**F 2 Η CH(CH3)CH2S02CH3 ch3 ch3 Ph~3~F**4~C 1 Η CH (CH3)CH2S02CH3 ch3 ch3 Ph-3, 4-Cl2 Η CH (CH3)CH2S02CH3 ch3 ch3 L - 46d Η CH (CH3)CH2S02CH3 ch3 Et Ph-4-F Η CH (CH3)CH2S02CH3 ch3 Et Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 Et Ph+Br Η CH (CH3)CH2S02CH3 ch3 Et Ph+CF3 Η CH (CH3)CH2S02CH3 ch3 Et Ph-4-0CHF2 Η CH (CH3)CH2S02CH3 ch3 Et Ph-4-0CF3 Η CH (CH3)CH2S02CH3 ch3 Et Ph-3, 4-Cl2 Η CH (CH3)CH2S02CH3 ch3 n - Pr Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 i-Pr Ph+Cl Η CH (CH3)CH2S02CH3 ch3 c - Pr H Η CH (CH3)CH2S02CH3 ch3 c-Pr Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 n-Bu Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 chf2 Ph-4-F Η CH (CH3)CH2S02CH3 ch3 chf2 Ph+Cl Η CH (CH3)CH2S02CH3 ch3 chf2 Ph+Br Η CH (CH3)CH2S02CH3 ch3 chf2 Ph-4-CF3 Η CH (CH3)CH2S02CH3 ch3 chf2 Ph-4-0CHF2 Η CH (CHa) CH2S02CH3 ch3 chf2 Ph~4-0CF3 Η CH (CH3)CH2S02CH3 ch3 chf2 Ph-3, 4-Cl2
434 314918 200407073 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH(CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H ch(ch3)ch2so2ch3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (GH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 gh3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3 H CH (CH3)CH2S02CH3 ch3 cf3
Ph-4-F
Ph+Cl
Pti-4-Br
Ph-4-I
Ph-4-CF 3
Ph-4~0CHF2
Ph-4-0CF3
Ph-4-0CF2Br
Ph-4-0CF2CHF2
Ph-4-0CF2CHFCl
Ph-4-0CF2CHFCF3 PH - 0CF2CHF0CF3 φ
Ph-4-0CF2CHF0CF2CF2CF3
Ph-3, 4-F2
Ph-3-F~4-Cl
Ph-3, 4~C12 L-lb L-lc L - Id L-le L-li L-2b L-3c L - 3e L-3i L-3j L - 3k L-31 L-3o L-4b L - 4c L-4e L-lOb L- 10c L-21b L~21c
435 314918 200407073
Η CH (CH3)CH2S02CH3 ch3 cf3 L - 21e Η ch(ch3)ch2so2ch3 ch3 cf3 L - 22b Η CH (CH3)CH2S02CH3 ch3 cf3 L-22c Η CH(CH3)CH2S02CH3 ch3 cf3 L-23b Η CH (CH3)CH2S02CH3 ch3 cf3 L-23c Η CH (CH3)CH2S02CH3 ch3 cf3 卜23i Η CH (CH3)CH2S02CH3 ch3 cf3 L-23g Η CH (CH3)CH2S02CH3 ch3 cf3 L - 31a Η CH (CH3)CH2S02CH3 ch3 cf3 L-31b Η CH (CH3)CH2S02CH3 ch3 cf3 L-45c Η CH(CH3)CH2S02CH3 ch3 cf3 L-45d Η CH (CH3)CH2S02CH3 ch3 cf3 L_45e Η CH (CH3)CH2S02CH3 ch3 cf3 L-45f Η CH (CH3)CH2S02CH3 ch3 cf3 L-45g Η CH (CH3)CH2S02CH3 ch3 cf3 L - 45ro Η CH (CH3)CH2S02CH3 ch3 cf3 L - 46c Η CH (CH3)CH2S02CH3 ch3 cf3 L-46d Η CH(CH3)CH2S02CH3 ch3 cf3 L-46e Η CH (CH3)CH2S02CH3 ch3 cf3 L - 46f Η CH (CH3)CH2S02CH3 ch3 cf3 L-46g Η CH (CH3)CH2S02CH3 ch3 cf3 L-46j Η CH (CH3)CH2S02CH3 ch3 cf3 L-46k Η CH (CH3)CH2S02CH3 ch3 cf3 L - 46r Η CH (CH3)CH2S02CH3 ch3 cf3 L-47a Η CH (CH3)CH2S02CH3 ch3 cf3 L-50b Η CH(CH3)CH2S02CH3 ch3 cf3 L-50c Η CH (CH3)CH2S02CH3 ch3 cf3 L-51b Η CH (CH3)CH2S02CH3 ch3 cf2ci Ph+F Η CH (CH3)CH2S02CH3 ch3 cf2ci Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 cf2ci Ph~4~Br Η CH (CH3)CH2S02CH3 ch3 cf2ci Ph-4-CF3 Η CH (CH3)CH2S02CH3 ch3 cf2ci Ph-4-0CHF Η CH (CH3)CH2S02CH3 ch3 cf2ci Ph-4-OCF3 Η CH (CH3)CH2S02CH3 ch3 cf2ci Ph-3, 4-C1 Η CH (CH3)CH2S02CH3 ch3 CF2Br Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 cf2chf2 Ph+Cl Η CH (CH3)CH2S02CH3 ch3 cf2cf3 Pli-4-F
436 314918 200407073
Η ch(ch3)ch2so2ch3 ch3 cf2cf3 Ph+Cl Η CH (CH3)CH2S02CH3 ch3 cf2cf3 Ph+Br Η CH (CH3)CH2S02CH3 ch3 cf2cf3 Ph-4-CF3 Η CH (CH3)CH2S02CH3 ch3 cf2cf3 Ph-4-0CHF2 Η CH (CH3)CH2S02CH3 ch3 cf2cf3 Ph-4-0CF3 Η CH (CH3)CH2S02CH3 ch3 cf2cf3 Ph-3, 4-Cl2 Η CH (CH3)CH2S02CH3 ch3 cf2cf2ci Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 cf2cf2cf3 Ph+Cl Η CH (CH3)CH2S02CH3 ch3 ch2och3 H Η CH (CH3)CH2S02CH3 ch3 CH20Et H Η CH (CH3)CH2S02CH3 ch3 ch2och2cf3 H Η CH (CH3)CH2S02CH3 ch3 ch2och2cf3 ch3 Η CH(CH3)CH2S02CH3 ch3 ch2och2cf3 Et Η CH (CH3)CH2S02CH3 ch3 ch2och2cf3 n~Pr Η CH (CH3)CH2S02CH3 ch3 ch2och2cf3 i-Pr Η CH(CH3)CH2S02CH3 ch3 ch2och2cf3 Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 ch2och2cf2cf3 H Η CH (CH3)CH2S02CH3 ch3 ch2och2cf2cf3 ch3 Η CH (CH3)CH2S02CH3 ch3 ch2och2cf2cf3 Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 cf2ocf2cf2ocf3 H Η CH (CH3)CH2S02CH3 ch3 CF (CF3)〇CF2CF2CF3 H Η CH (CH3)CH2S02CH3 ch3 ch2sch3 H Η CH (CH3)CH2S02CH3 ch3 ch2so2ch3 H Η CH (CH3)CH2S02CH3 ch3 CH2SEt H Η CH (CH3)CH2S02CH3 ch3 ch2scf3 H Η CH (CH3)CH2S02CH3 ch3 ch2scf3 Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 ch2scf3 Ph-4-0CF3 Η CH (CH3)CH2S02CH3 ch3 CH2SPh H Η CH (CH3)CH2S02CH3 ch3 och3 H Η CH(CH3)CH2S02CH3 ch3 och3 Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 so2cf3 H Η CH (CH3)CH2S02CH3 ch3 SPh H Η CH (CH3)CH2S02CH3 ch3 T-22 H Η CH (CH3)CH2S02CH3 ch3 T-23 H Η CH (CH3)CH2S02CH3 ch3 T - 24 H Η CH (CH3)CH2S02CH3 ch3 Ph H Η CH (CH3)CH2S02CH3 ch3 Ph-4-F H
437 314918 200407073 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3 H CH (CH3)CH2S02CH3 ch3
Ph-4-Cl Η
Ph-4-Br Η
Ph+Ι Η
Ph-4-CF3 Η
Ph-4-CH20CH2CF3 Η
Ph-4-C (CF3) 2〇Η Η
Ph-4-0CHF2 Η
Ph-4-0CF3 Η
Ph-4-0CF2Br Η
Ph-4-0CH2CF3 Η
Ph-4-0CF2CHF2 Η
Ph-4-0CF2CHFCl Η
Ph-4_0CF2CHFBr Η
Ph-4-0CF2CF2Br Η
Ph-4-0CF2CHFCF3 Η
Ph-4-0CH(CF3)2 Η
Ph-4-0CF2CHF0CF3 Η
Ph-4-0CF2CHF0CF2CF2CF3 Η Ph-4-0S02CH3 Η
Ph-4-0S02CF3 Η
Ph-4-0(Ph-4-CF3) Η
Ph-3-0 (L-45g) H
Ph - 4-0 (L - 45g) H
Ph - 4 -0(L-451) H
Ph-4-SCH3 H
Ph-4-S (0) CH3 H
Ph-4-S02CH3 H
Ph-4-SCF3 H
Ph-4-S ⑼ CF3 H
Ph-4-S02CF3 H
Ph+N02 H
Ph-4-CN H
Ph-4-C ⑼ NH2 H
Ph-4-C (S)NH2 H
Ph-3,4-F2 H
Ph-3-F-4-Cl H
Ph-3,4-Cl2 H
438 314918 200407073
Η CH (CH3)CH2S02CH3 ch3 Ph-3-F-4-CF3 H Η ch(ch3)ch2so2ch3 ch3 Ph~3-F-4-0CHF2 H Η CH (CH3)CH2S02CH3 ch3 Ph-3-Cl-4-0CHF2 H Η CH (CH3)CH2S02CH3 ch3 Ph-3~F-4-0CF3 H Η CH(CH3)CH2S02CH3 ch3 Ph-3 - H-4-0CF3 H Η CH (CH3)CH2S02CH3 ch3 Ph-3~F~4~0CF2Br H Η CH (CH3)CH2S02CH3 ch3 2-Naph H Η CH (CH3)CH2S02CH3 ch3 L-lb H Η CH (CH3)CH2S02CH3 ch3 L-lc H Η CH (CH3)CH2S02CH3 ch3 L - Id H' Η CH (CH3)CH2S02CH3 ch3 L-le H Η CH (CH3)CH2S02CH3 ch3 L- li H Η CH(CH3)CH2S02CH3 ch3 L - 2b H Η CH (CH3)CH2S02CH3 ch3 L-3c H Η CH (CH3)CH2S02CH3 ch3 L-3d H Η CH (CH3)CH2S02CH3 ch3 L-3e H Η CH(CH3)CH2S02CH3 ch3 L-3f H Η CH (CH3)CH2S02CH3 ch3 L-3k H Η CH (CH3)CH2S02CH3 ch3 L-31 H Η CH (CH3)CH2S02CH3 ch3 L-3o H Η CH (CH3)CH2S02CH3 ch3 L - 4b H Η CH (CH3)CH2S02CH3 ch3 L - 4c H Η CH (CH3)CH2S02CH3 ch3 L-6d H Η CH (CH3)CH2S02CH3 ch3 L-6e H Η CH (CH3)CH2S02CH3 ch3 L-lOb H Η CH (CH3)CH2S02CH3 ch3 L-lOc H Η CH (CH3)CH2S02CH3 ch3 L-16a H Η CH (CH3)CH2S02CH3 ch3 L- 16b H Η CH (CH3)CH2S02CH3 ch3 L- 17a H Η CH (CH3)CH2S02CH3 ch3 L-21b H Η CH (CH3)CH2S02CH3 ch3 L-21c H Η CH (CH3) CH2S02CH3 ch3 L-21d H Η CH (CH3)CH2S02CH3 ch3 L~21e H Η CH (CH3)CH2S02CH3 ch3 L-22b H Η CH (CH3)CH2S02CH3 ch3 L - 22c H Η CH (CH3)CH2S02CH3 ch3 L - 23b H Η CH (CH3)CH2S02CH3 ch3 L-23c H
439 314918 200407073 Η ch(ch3)ch2so2ch3 ch3 L-23i H Η ch(ch3)ch2so2ch3 ch3 L-23g H Η CH (CH3)CH2S02CH3 ch3 L-31a H Η CH (CH3)CH2S02CH3 ch3 L-31b H Η CH (CH3)CH2S02CH3 ch3 L-45d H Η CH (CH3)CH2S02CH3 ch3 L-45e H Η CH (CH3)CH2S02CH3 ch3 L-45i H Η CH (CH3)CH2S02CH3 ch3 L - 45g H Η CH (CH3)CH2S02CH3 ch3 L - 451 H Η CH (CH3)CH2S02CH3 ch3 L-45m H Η CH (CH3)CH2S02CH3 ch3 L-46d H Η CH (CH3)CH2S02CH3 ch3 L-46e H Η CH (CH3)CH2S02CH3 ch3 L - 46f H Η CH (CH3)CH2S02CH3 ch3 L - 46g H Η CH (CH3)CH2S02CH3 ch3 L-46j H Η CH (CH3)CH2S02CH3 ch3 L-46k H Η CH (CH3)CH2S02CH3 ch3 卜46r H Η CH (CH3)CH2S02CH3 ch3 L-47a H Η CH (CH3)CH2S02CH3 ch3 L-47e H Η CH (CH3)CH2S02CH3 ch3 LiOb H Η CH (CH3)CH2S02CH3 ch3 L-50c H Η CH (CH3)CH2S02CH3 ch3 L - 50d H Η CH (CH3)CH2S02CH3 ch3 L-51b H Η CH (CH3)CH2S02CH3 Et cf3 Ph+Cl Η CH (CH3)CH2S02CH3 Et Ph-4-〇CF 3 H Η CH (CH3)CH2S02CH3 ch2oh cf3 Ph-4-Cl Η CH (CH3)CH2S02CH3 ch2oh Ph-4-0CF3 H Η CH (CH3)CH2S02CH3 och3 cf3 Ph-4-Cl Η CH (CH3)CH2S02CH3 och3 Ph~4~0CF 3 H Η CH (CH3)CH2S02CH3 sch3 cf3 Ph-4-Cl Η CH (CH3)CH2S02CH3 sch3 Ph-4-0CF3 H Η CH (CH3)CH2SEt ch3 cf3 Ph-4-F Η CH (CH3)CH2SEt ch3 cf3 Ph-4-Cl Η CH (CH3)CH2SEt ch3 cf3 Ph-4~Br Η CH (CH3)CH2SEt ch3 cf3 Ph-4~CF 3 Η CH (CH3)CH2SEt ch3 cf3 Ph-4-0CHF Η CH (CH3)CH2SEt ch3 cf3 Ph-4-0CF3
440 314918 200407073 Η CH(CH3)CH2SEt ch3 Ph-4-F H Η CH(CH3)CH2SEt ch3 Ph-4-Cl H Η CH(CH3)CH2SEt ch3 Ph-4-Br H Η CH (CH3)CH2SEt ch3 Ph-4-CF3 H Η CH(CH3)CH2SEt ch3 Ph-4-0CHF2 H Η CH (CH3)CH2SEt ch3 Ph-4-0CF3 H Η CH (CH3)CH2SEt(R) ch3 Ph-4-0CF3 H Η CH (CH3)CH2SEt(S) ch3 Ph-4-OCFs H Η CH (CH3)CH2SEt ch3 Ph-4-0 (L - 45g) H Η CH(CH3)CH2S«))Et ch3 cf3 Ph-4-F Η CH (CH3)CH2S(0)Et ch3 cf3 Ph+Cl Η CH (CH3)CH2S(0)Et ch3 cf3 Ph-4-Br Η CH(CH3)CH2S(0)Et ch3 cf3 Ph+CF3 Η CH (CH3)CH2S(0)Et ch3 cf3 Ph-4-0CHF Η CH(CH3)CH^0)Et ch3 cf3 Ph+0CF3 Η CH (CH3)CH2S(0)Et ch3 Ph-4-F H Η CH (CH3)CH2S(0)Et ch3 Ph-4-Cl H Η CH (CH3)CH2S(0)Et ch3 Ph-4-Br H Η CH(CH3)CH2S(0)Et ch3 Ph+CF3 H Η CH (CH3)CH2S(0)Et ch3 Ph+0CHF2 H Η CH (CH3)CH2S(0)Et ch3 Ph-4-0CF3 H Η CH(CH3)CH2S(0)Et ch3 Ph-4-0 (L-45g) H Η CH (CH3)CH2S02Et ch3 cf3 Ph-4~F Η CH (CH3)CH2S02Et ch3 cf3 Ph-4-Cl Η CH (CH3)CH2S02Et ch3 cf3 Ph+Br Η CH (CH3)CH2S02Et ch3 cf3 Ph-4-CF 3 Η CH(CH3)CH2S02Et ch3 cf3 Ph-4-0CHF Η CH (CH3)CH2S02Et ch3 cf3 Ph-4-0CF3 Η CH(CH3)CH2S02Et ch3 Ph-4-F H Η CH(CH3)CH2S02Et ch3 Ph+Cl H Η CH(CH3)CH2S02Et ch3 Ph+Br H Η CH (CH3)CH2S02Et ch3 Ph-4-CF3 H Η CH (CH3)CH2S02Et ch3 Ph-4~0CHF2 H Η CH (CH3)CH2S02Et ch3 Ph~4~0CF 3 H Η CH (CH3)CH2S02Et ch3 Ph - 4-0 (L - 45g) H Η CH(CH3)CH2SPr-n ch3 cf3 Ph-4-F Η CH (CH3)CH2SPr-n ch3 cf3 PH-Cl
441 314918 200407073
Η CH(CH3)CH2SP 卜 η ch3 cf3 Ph-4-Br Η CH (CH3)CH2SPr-n ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2SPr-n ch3 cf3 Ph-4-OCHF Η CH (CH3)CH2SPr-n ch3 cf3 Ph-4-OCFa Η CH(CH3)CH2SPr - n ch3 Ph-4_F H Η CH (CH3)CH2SPr-n ch3 Ph-4-Cl H Η CH(CH3)CH2SPr - n ch3 Ph-4-Br H Η CH (CH3)CH2SPr-n ch3 Ph-4-CF3 H Η CH (CH3)CH2SPr-n ch3 Ph-4-0CHF2 H Η CH(CH3&gt;CH2SPr - n ch3 Ph-4-OCF 3 H Η CH(CH3)CH2SPr - n ch3 Ph-4-0 (L-45g) H Η CH(CH3)CH2SBiH ch3 cf3 Ph~4_F Η CH (CH3)CH2SBu-i ch3 cf3 Ph+Cl Η CH(CH3)CH2SBu - i ch3 cf3 Ph-4~Br Η CH (CH3)CH2SBu-i ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2SBu-i ch3 cf3 Ph-4~0CHF Η CH (CH3)CH2SBu-i ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2SBu-i ch3 Ph-4-F H Η CH(CH3)CH2SBu-i ch3 Ph-4-Cl H Η CH(CH3)CH2SBu-i ch3 Ph-4-Br H Η CH(CH3)CH2SBiH ch3 Ph-4-CF3 H Η CH (CH3)CH2SBu-i ch3 Ph-4_0CHF2 H Η CH(CH3)CH2SBu - i ch3 Ph-4-0CF3 H Η CH(CH3)CH2SBu-i ch3 Ph - 4-0(L - 45g&gt; H Η CH (CH3)CH2SBu-t ch3 cf3 Ph-4-F Η CH (CH3)CH2SBu-t ch3 cf3 Ph-4-Cl Η CH(CH3)CH2SBu-t ch3 cf3 Ph-4-Br Η CH(CH3)CH2SBu -1 ch3 cf3 Ph-4-CF 3 Η CH(CH3)CH2SBu-t ch3 cf3 Ph-4-OCHF Η CH(CH3&gt;CH2SBu -1 ch3 cf3 Ph-4-0CF3 Η CH(CH3)CH2SBu~t ch3 Ph-4-F H Η CH (CH3)CH2SBu-t ch3 Ph-4-Cl H Η CH (CH3)CH2SBu-t ch3 Ph-4-Br H Η CH (CH3)CH2SBu-t ch3 Ph+CF3 H Η CH(CH3)CH2SBu-t ch3 Ph-4-0CHF2 H Η CH(CH3)CH2SBu-t ch3 Ph-4-0CF3 H Η CH (CH3)CH2SBu-t ch3 Ph - 4-0 (L-45g) H
442 334918 200407073
Η CH (CH3)CH2SCH2Si(CH3)3 ch3 cf3 Ph-4-F Η CH (CH3)CH2SCH2Si(CH3)3 ch3 cf3 Ph+Cl Η CH (CH3)CH2SCH2Si(CH3)3 ch3 cf3 Ph-4~Br Η CH (CH3)CH2SCH2Si(CH3)3 ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2SCH2Si(CH3)3 ch3 cf3 Ph-4-0CHF Η CH (CH3)CH2SCH2Si(CH3)3 ch3 cf3 Ph-4~0CF3 Η CH (CH3)CH2SCH2Si(CH3)3 ch3 Ph-4-F H Η CH (CH3)CH2SCH2Si(CH3)3 ch3 Ph-4-Cl H Η CH (CH3)CH2SCH2Si(CH3)3 ch3 Ph-4-Br H Η CH (CH3)CH2SCH2Si(CH3)3 ch3 Ph-4-CF3 H Η CH (CH3)CH2SCH2Si(CH3)3 ch3 Ph-4-0CHF2 H Η CH (CH3)CH2SCH2Si(CH3)3 ch3 Ph-4-0CF3 H Η CH(CH3)CH2SCH2Si(CH3)3 ch3 Ph-4-0(L-45g&gt; H Η CH (CH3)CH2SPh ch3 cf3 Ph-4-F Η CH (CH3)CH2SPh ch3 cf3 Ph-4-Cl Η CH(CH3)CH2SPh ch3 cf3 Ph+Br Η CH (CH3)CH2SPh ch3 cf3 Ph~4-CF 3 Η CH (CH3)CH2SPh ch3 cf3 Ph-4-OCHF； Η CH (CH3)CH2SPh ch3 cf3 Ph-4-0CF3 Η CH(CH3)CH2SPh ch3 Ph-4-F H Η CH (CH3)CH2SPh ch3 Ph+Cl H Η CH (CH3)CH2SPh ch3 Ph-4-Br H Η CH (CH3)CH2SPh ch3 Ph-4-CF 3 H Η CH (CH3)CH2SPh ch3 Ph-4-0CHF2 H Η CH (CH3)CH2SPh ch3 Ph+0CF3 H Η CH (CH3)CH2SPh ch3 Ph-4-0 (L-45g) H Η CH (CH3)CH2S(L-45a) ch3 cf3 Ph-4~F Η CH (CH3) CH2Sa-45a) ch3 cf3 Ph-4-Cl Η CH (CH3)CH2S(L-45a) ch3 cf3 Ph-4-Br Η CH (CH3)CH2S(L-45a) ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2Sa-45a) ch3 cf3 Ph-4-OCHF： Η CH (CH3)CH2Sa-45a) ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2S(L-45a) ch3 Ph-4-F H Η CH (CH3)CH2S(L-45a) ch3 Ph+Cl H Η CH(CH3)CH2Sa-45a) ch3 Ph~4~Br H Η CH (CH3) CH2$a-45a) ch3 Ph-4-CF3 H Η CH (CH3)CH2S(L-45a) ch3 Ph-4-0CHF2 H
443 314918 200407073
Η CH (CH3)CH2S(L-45a) ch3 Ph-4-0CF3 H Η CH (CH3)CH2S(L-45a) ch3 Ph-4-0 (L-45g) H Η CH(CH3)CH2S(0) (L-45a) ch3 cf3 Ph_4-F Η CH(CH3)CH2S(0) (L-45a) ch3 cf3 Ph-4-Cl Η CH(CH3)CH2S(0) (L-45a) ch3 cf3 PIH -Br Η CH(CH3)CH2S(0) (L-45a) ch3 cf3 Ph-4-CF3 Η CH(CH3)CH2S(0) (L-45a) ch3 cf3 Ph-4-OCHF Η CH(CH3) CH2S(0) (L-45a) ch3 cf3 Ph-4-0CF3 Η CH(CH3)CH2S(0) (L-45a) ch3 Ph-4_F H Η CH(CH3)CH2S(0) (L-45a&gt; ch3 Ph-4-Cl H Η CH(CH3)CH2S(0) (L-45a) ch3 Ph-4-Br H Η CH(CH3)CH2S(0) (L_45a) ch3 Ph+CF3 H Η CH(CH3)CH2S(0) (L-45a) ch3 Ph-4-0CHF2 H Η CH(CH3)CH2S(0) (L-45a) ch3 Ph-4_0CF3 H Η CH(CH3)CH2S(0) (L-45a) ch3 Ph-4-0 (L-45g) H Η CH(CH3)CH2S02(L-45a) ch3 cf3 Ph-4-F Η CH (CH3)CH2S02(L-45a) ch3 cf3 Ph-4-Cl Η CH (CH3)CH2S02 (L-45a) ch3 cf3 Ph-4-Br Η CH (CH3)CH2S02(L-45a) ch3 cf3 Ph*~4-CF 3 Η CH(CH3)CH2S02(L-45a) ch3 cf3 Ph-4-0CHF Η CH (CH3)CH2S02(L-45a) ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2S02(L-45a) ch3 Ph-4-F H Η CH(CH3)CH2S02(L - 45a) ch3 Ph+Cl H Η CH(CH3)CH2S02(L - 45a&gt; ch3 Ph-4-Br H Η CH (CH3)CH2S02(L-45a) ch3 Ph-4-CF3 H Η CH(CH3)CH2S02(L - 45a) ch3 Ph-4-0CHF2 H Η CH(CH3)CH2S02(L - 45a&gt; ch3 Ph-4-0CF3 H Η CH (CH3)CH2S02 (L-45a) ch3 Ph-4-0 (L-45g) H Η CH (CH3)CH2SSCH3 ch3 cf3 Ph-4-F Η CH (CH3)CH2SSCH3 ch3 cf3 Ph-4-Cl Η CH (CH3)CH2SSCH3 ch3 cf3 Ph+Br Η CH (CH3)CH2SSCH3 ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2SSCH3 ch3 cf3 Ph-4-0CHF Η CH (CH3)CH2SSCH3 ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2SSCH3 ch3 Ph-4-F H Η CH (CH3)CH2SSCH3 ch3 PH-Cl H Η CH (CH3)CH2SSCH3 ch3 Ph-4-Br H
444 314918 200407073 Η CH(CH3)CH2SSCH3 ch3 Ph-4-CF3 H Η CH (CH3)CH2SSCH3 ch3 Ph+0CHF2 H Η CH (CH3)CH2SSCH3 ch3 Ph+0CF3 H Η CH (CH3)CH2SSCH3 ch3 Ph - 4 一0 (L-45g) H Η c(ch3)2ch2sch3 F cf3 Ph-4-F Η C(CH3)2CH2SCH3 F cf3 Ph+Cl Η C(CH3)2CH2SCH3 F cf3 Ph-4-Br Η c(ch3)2ch2sch3 F cf3 Ph-4-CF3 Η C(CH3)2CH2SCH3 F cf3 Ph-4-0CHF2 Η c(ch3) 2ch2sch3 F cf3 Ph-4-0CF3 Η c(ch3) 2ch2sch3 F cf3 Ph-3,4-Cl2 Η C(CH3) 2ch2sch3 F Ph+F H Η C(CH3)2CH2SCH3 F Ph-4-Cl H Η c(ch3)2ch2sch3 F Ph-4-Br H Η c(ch3)2ch2sch3 F Ph~4~CF 3 H Η c(ch3)2ch2sch3 F Ph-4-0CHF2 H Η C(CH3)2CH2SCH3 F Ph-4-0CF3 H Η c(ch3)2ch2sch3 F Ph - 4_0 (L - 45g&gt; H Η C(CH3)2CH2SCH3 F Ph-3, 4-Cl2 H Η C(CH3) 2ch2sch3 Cl cf3 Ph+F Η C(CH3)2CH2SCH3 Cl cf3 Ph-4-Cl Η c(ch3)2ch2sch3 Cl cf3 Ph-4-Br Η C(CH3) 2ch2sch3 Cl cf3 Ph-4-CF3 Η C(CH3)2CH2SCH3 Cl cf3 Ph-4-0CHF2 Η C(CH3)2CH2SCH3 Cl cf3 Ph-4-OCFa Η C(CH3)2CH2SCH3 Cl cf3 Ph-3, 4-Cl2 Η c(ch3) 2ch2sch3 Cl Ph-4-F H Η C(CH3)2CH2SCH3 Cl Ph-4-C1 H Η c(ch3)2ch2sch3 Cl Ph+Br H Η · C(CH3)2CH2SCH3 Cl Ph-4-CF3 H Η c(ch3)2ch2sch3 , Cl Ph-4-0CHF2 H Η C(CH3)2CH2SCH3 Cl Ph-4-0CF3 H Η c《ch3&gt;2ch2sch3 Cl Ph - 4-0(L - 45g) H Η c(ch3)2ch2sch3 Cl Ph-3,4-Cl2 H Η c(ch3)2ch2sch3 Br cf3 Ph+F Η C(CH3) 2ch2sch3 Br cf3 PM-Cl Η c(ch3)2ch2sch3 Br cf3 Ph-4-Br 445 314918 200407073 Η C(CH3)2CH2SCH3 Br cf3 Ph-4-CF3 Η C(CH3) 2ch2sch3 Br cf3 Pli - 4-0CHF2 Η c(ch3)2ch2sch3 Br cf3 Ph-4-0CF3 Η c(ch3) 2ch2sch3 Br cf3 Ph-3, 4-Cl2 Η C(CH3)2CH2SCH3 Br Ph-4-F H Η C(CH3)2CH2SCH3 Br Ph-4-Cl H Η C(CH3)2CH2SCH3 Br Ph~4~Br H Η C(CH3) 2ch2sch3 Br Ph-4-CF3 H Η c(ch3)2ch2sch3 Br Ph-4-0CHF2 H Η C(CH3)2CH2SCH3 Br Ph+0CF3 H Η C(CH3) 2ch2sch3 Br Ph-4-0 (L-45g) H Η C(CH3)2CH2SCH3 Br Ph - 3,4_C12 H Η C(CH3) 2ch2sch3 ch3 H Ph Η c(ch3)2ch2sch3 ch3 H Ph-4-Cl Η C(CH3)2CH2SCH3 ch3 F Ph-4-F Η C(CH3)2CH2SCH3 ch3 F Ph-4-Cl Η c(ch3)2ch2sch3 ch3 F Ph-4-Br Η C(CH3)2CH2SCH3 ch3 F Ph-4-CF3 Η C(CH3)2CH2SCH3 ch3 F Ph+0CHF2 Η C(CH3)2CH2SCH3 ch3 F Ph-4-0CF3 Η C(CH3)2CH2SCH3 ch3 F Ph-3, 4-Cl2 Η c(ch3)2ch2sch3 ch3 Cl Ph-4-F Η c(ch3)2ch2sch3 ch3 Cl Ph-4-Cl Η C(CH3)2CH2SCH3 ch3 Cl Ph - 4*~Br Η C(CH3)2CH2SCH3 ch3 Cl Ph-4-I Η C(CH3)2CH2SCH3 ch3 Cl Ph-4-CF3 Η C(CH3)2CH2SCH3 ch3 Cl Ph-4-0CHF2 Η C(CH3)2CH2SCH3 ch3 Cl Ph-4-0CF3 Η c(ch3&gt;2ch2sch3 ch3 Cl Ph-4-0CF2Br Η c(ch3)2ch2sch3 ch3 Cl Ph-4-0CF2CHF2 Η c(ch3)2ch2sch3 ch3 Cl Ph-4-0CF2CHFCl Η C(CH3)2CH2SCH3 ch3 Cl Ph-4-0CF2CHFCF3 Η C(CH3)2CH2SCH3 ch3 Cl Ph-4-0CF2CHF0CF Η C(CH3)2CH2SCH3 ch3 Cl Ph-4-0 (L-45g) Η c(ch3)2ch2sch3 ch3 Cl Ph-3, 4-Cl2 Η C(CH3)2CH2SCH3 ch3 Br Ph-4-F Η C(CH3)2CH2SCH3 ch3 Br Ph-4-Cl
446 314918 200407073 Η C(CH3)2CH2SCH3 ch3 Br Ph-4-Br Η c(ch3)2ch2sch3 ch3 Br Ph-4-CF3 Η C(CH3)2CH2SCH3 ch3 Br Ph-4-0CHF2 Η c(ch3)2ch2sch3 ch3 Br Ph+0CF3 Η C(CH3) 2ch2sch3 ch3 Br Ph-3, 4-Cl2 Η c(ch3) 2ch2sch3 ch3 ch3 Ph+F Η c(ch3)2ch2sch3 ch3 ch3 Ph-4-Cl Η c(ch3)2ch2sch3 ch3 ch3 Ph-4-Br Η C(CH3}2CH2SCH3 ch3 ch3 Ph-4-CF3 Η C(CH3) 2ch2sch3 ch3 ch3 Ph-4-0CHF2 Η C(CH3)2CH2SCH3 ch3 ch3 Ph-4-0CF3 Η C(CH3)2CH2SCH3 ch3 ch3 Ph-4-0CF2Br Η C(CH3) 2ch2sch3 ch3 ch3 Ph-4-0CF2CHFCF Η C(CH3)2CH2SCH3 ch3 ch3 Ph~3, 4-F2 Η c(ch3)2ch2sch3 ch3 ch3 Ph-3-F-4-Cl Η C(CH3)2CH2SCH3 ch3 ch3 Ph-3, 4-Cl2 Η c(ch3)2ch2sch3 ch3 ch3 L - 46d Η C(CH3)2CH2SCH3 ch3 Et PH - F Η C(CH3)2CH2SCH3 ch3 Et Ph+Cl Η C(CH3)2CH2SCH3 ch3 Et Ph-4~Br Η c(ch3)2ch2sch3 ch3 Et Ph-4-CF3 Η c(ch3)2ch2sch3 ch3 Et Ph-4-0CHF2 Η c(ch3)2ch2sch3 ch3 Et Ph-4-0CF3 Η c(ch3)2ch2sch3 ch3 Et Ph-3, 4-Cl2 Η c(ch3)2ch2sch3 ch3 n-Pr Ph-4-Cl Η c(ch3)2ch2sch3 ch3 i-Pr Ph-4-Cl Η c(ch3)2ch2sch3 ch3 c - Pr H Η C(CH3)2CH2SCH3 ch3 c-Pr Ph-4-Cl Η C(CH3)2CH2SCH3 ch3 n - Bu PH-Cl Η C(CH3)2CH2SCH3 ch3 s-Bu Ph-4-Cl Η C(CH3)2CH2SCH3 ch3 i - Bu Ph+Cl Η C(CH3)2CH2SCH3 ch3 c-Bu H Η C(CH3)2CH2SCH3 ch3 c-Bu Ph-4-Cl Η C(CH3)2CH2SCH3 ch3 n-Pen Ph-4-Cl Η c(ch3)2ch2sch3 ch3 c-Pen H Η c(ch3)2ch2sch3 ch3 c - Pen Ph+Cl Η c(ch3)2ch2sch3 ch3 n - Hex Ph+Cl 447 314918 200407073
Η c(ch3)2ch2sch3 ch3 c-Hex H Η C(CH3)2CH2SCH3 ch3 c-Hex Ph-4-Cl Η c(ch3) 2ch2sch3 ch3 ch2f Ph-4-Cl Η C(CH3) 2ch2sch3 ch3 ch2ci Ph-4-Cl Η C(CH3) 2ch2sch3 ch3 CH2Br Ph+Cl Η c(ch3)2ch2sch3 ch3 chf2 Ph-4-F Η c(ch3)2ch2sch3 ch3 chf2 Ph-4-Cl Η c(ch3&gt;2ch2sch3 ch3 chf2 Ph-4-Br Η c(ch3)2ch2sch3 ch3 chf2 Ph-4-CF3 Η C(CH3) 2ch2sch3 ch3 chf2 Ph-4-0CHF2 Η c(ch3)2ch2sch3 ch3 chf2 Ph-4-0CF3 Η C(CH3)2CH2SCH3 ch3 chf2 Ph«3, 4-Cl2 Η c(ch3)2ch2sch3 ch3 cf3 Ph Η C(CH3) 2ch2sch3 ch3 cf3 Ph-4-F Η C(CH3) 2ch2sch3 ch3 cf3 Ph-4-Cl Η C(CH3)2CH2SCH3 ch3 cf3 Ph-4-Br Η C(CH3)2CH2SCH3 ch3 cf3 Ph+I Η c(ch3)2ch2sch3 ch3 cf3 Ph-4-CF 3 Η c(ch3)2ch2sch3 ch3 cf3 Ph-4-C (CF3) 2〇H Η C(CH3)2CH2SCH3 ch3 cf3 Ph~4-0CHF2 Η c(ch3) 2ch2sch3 ch3 cf3 Ph-4-0CF3 Η c(ch3)2ch2sch3 ch3 cf3 Ph-4-0CF2Br Η C(CH3) 2ch2sch3 ch3 cf3 Ph-4-0CF2CHF2 Η c(ch3)2ch2sch3 ch3 cf3 Ph_4_0CF2CHFCl Η C(CH3)2CH2SCH3 ch3 cf3 Ph-4-0CF2CHFCF3 Η c(ch3)2ch2sch3 ch3 cf3 Ph-4-0CF2CHF0CF3 Η C(CH3)2CH2SCH3 ch3 cf3 Ph-4-0CF2CHF0CF2CF2CF3 Η C(CH3) 2ch2sch3 ch3 cf3 Ph-3, 4-F2 Η C(CH3)2CH2SCH3 ch3 cf3 Ph-3-F-4-Cl Η C(CH3) 2ch2sch3 ch3 cf3 Ph - 3,4-Cl2 Η C(CH3)2CH2SCH3 ch3 cf3 Ph-3-F-4-CF3 Η C(CH3)2CH2SCH3 ch3 cf3 Ph-3-F-4-0CHF2 Η C(CH3)2CH2SCH3 ch3 cf3 Ph-3~Cl-4-0CHF2 Η c(ch3) 2ch2sch3 ch3 cf3 Ph-3-F-4-0CF 3 Η c(ch3&gt;2ch2sch3 ch3 cf3 Ph-3-Cl_[0CF3 Η C(CH3)2CH2SCH3 ch3 cf3 Ph (-3-0CF20-4-) Η C(CH3)2CH2SCH3 ch3 cf3 Ph(-3_0CF2CF2(HH
448 314918 200407073 Η C(CH3)2CH2SCH3 ch3 cf3 2-Naph Η C(CH3)2CH2SCH3 ch3 cf3 L - lb Η C(CH3)2CH2SCH3 ch3 cf3 L-lc Η C(CH3) 2ch2sch3 ch3 cf3 L - Id Η c(ch3) 2ch2sch3 ch3 cf3 L - le Η C(CH3) 2ch2sch3 ch3 cf3 L-li Η c(ch3) 2ch2sch3 ch3 cf3 L-2b Η C(CH3) 2ch2sch3 ch3 cf3 L - 3c Η c(ch3)2ch2sch3 ch3 cf3 L-3d Η C(CH3) 2ch2sch3 ch3 cf3 L - 3e Η c(ch3)2ch2sch3 ch3 cf3 L-3i Η C(CH3)2CH2SCH3 ch3 cf3 L - 3j Η C(CH3) 2ch2sch3 ch3 cf3 L - 3k Η c(ch3)2ch2sch3 ch3 cf3 L-31 Η C(CH3)2CH2SCH3 ch3 cf3 L - 3o Η C(CH3)2CH2SCH3 ch3 cf3 L-4b Η C(CH3)2CH2SCH3 ch3 cf3 L - 4c Η C(CH3)2CH2SCH3 ch3 cf3 L - 4e Η C(CH3)2CH2SCH3 ch3 cf3 L-lOb Η c(ch3)2ch2sch3 ch3 cf3 L-10c Η C(CH3)2CH2SCH3 ch3 cf3 L-16a Η c(ch3)2ch2sch3 ch3 cf3 L-16b Η c(ch3)2ch2sch3 ch3 cf3 L-17a Η c(ch3)2ch2sch3 ch3 cf3 L-21b Η C(CH3) 2ch2sch3 ch3 cf3 L~21c Η c(ch3)2ch2sch3 ch3 cf3 L_21e Η C(CH3)2CH2SCH3 ch3 cf3 L - 22b Η c(ch3)2ch2sch3 ch3 cf3 L-22c Η c(ch3)2ch2sch3 ch3 cf3 L-23b Η C(CH3)2CH2SCH3 ch3 cf3 L-23c Η C(CH3)2CH2SCH3 ch3 cf3 L-23i Η C(CH3) 2ch2sch3 ch3 cf3 L-23g Η C(CH3)2CH2SCH3 ch3 cf3 L-31 a Η C(CH3)2CH2SCH3 ch3 cf3 L-31b Η c(ch3)2ch2sch3 ch3 cf3 L - 45c Η c(ch3)2ch2sch3 ch3 cf3 L - 45d Η c(ch3)2ch2sch3 ch3 cf3 L-45e
449 314918 C(CH3)2CH2SCH3 ch3 cf3 L - 45i C(CH3)2CH2SCH3 ch3 cf3 L - 45g C(CH3)2CH2SCH3 ch3 cf3 L-45m C(CH3)2CH2SCH3 ch3 cf3 L-46c c(ch3)2ch2sch3 ch3 cf3 L-46d c(ch3)2ch2sch3 ch3 cf3 L-46e C(CH3)2CH2SCH3 ch3 cf3 L-46f C(CH3)2CH2SCH3 ch3 cf3 L*46g C(CH3)2CH2SCH3 ch3 cf3 L-46j C(CH3)2CH2SCH3 ch3 cf3 L-46k c(ch3)2ch2sch3 ch3 cf3 L-46r c(ch3)2ch2sch3 ch3 cf3 L-47a C(CH3)2CH2SCH3 ch3 cf3 L-50b C(CH3)2CH2SCH3 ch3 cf3 L-50c C(CH3)2CH2SCH3 ch3 cf3 L-51b C(CH3)2CH2SCH3 ch3 cf2ci Ph-4-F c(ch3)2ch2sch3 ch3 cf2ci Ph+Cl c(ch3)2ch2sch3 ch3 cf2ci Ph-4-Br C(CH3)2CH2SCH3 ch3 cf2ci Ph-4-CF3 C(CH3)2CH2SCH3 ch3 cf2ci Ph-4-0CHF2 c(ch3&gt;2ch2sch3 ch3 cf2ci Ph~4~0CF 3 c(ch3)2ch2sch3 ch3 cf2ci Ph-3, 4-Cl2 C(CH3)2CH2SCH3 ch3 CF2Br Ph-4-F C(CH3)2CH2SCH3 ch3 CF2Br Ph+Cl c(ch3)2ch2sch3 ch3 CF2Br Ph-4-0CHF2 c(ch3)2ch2sch3 ch3 cf2chf2 Ph~4~F C(CH3)2CH2SCH3 ch3 cf2chf2 Ph-4-Cl C(CH3)2CH2SCH3 ch3 cf2chf2 Ph-4-0CHF2 c(ch3)2ch2sch3 ch3 cf2cf3 Ph~4-F C(CH3)2CH2SCH3 ch3 cf2cf3 Ph+Cl c(ch3)2ch2sch3 ch3 cf2cf3 Ph~4~Br C(CH3)2CH2SCH3 ch3 cf2cf3 Ph-4-CF 3 c(ch3)2ch2sch3 ch3 cf2cf3 Ph-4-0CHF2 C(CH3)2CH2SCH3 ch3 cf2cf3 Ph-4-0CF3 C(CH3)2CH2SCH3 ch3 cf2cf3 Ph-3, 4-Cl2 c(ch3)2ch2sch3 ch3 cf2cf2ci Ph+Cl c(ch3)2ch2sch3 ch3 CFCICFa Ph+Cl 450
314918 C(CH3)2CH2SCH3 c(ch3)2ch2sch3 c(ch3)2ch2sch3 c(ch3) 2ch2sch3 C(CH3)2CH2SCH3 C(CH3)2CH2SCH3 c(ch3)2ch2sch3 C(CH3)2CH2SCH3 C(CH3)2CH2SCH3 C(CH3)2CH2SCH3 C(CH3)2CH2SCH3 C(CH3)2CH2SCH3 C(CH3) 2ch2sch3 c(ch3)2ch2sch3 C(CH3)2CH2SCH3 c(ch3)2ch2sch3 C(CH3)2CH2SCH3 c(ch3)2ch2sch3 C(CH3)2CH2SCH3 c(ch3) 2ch2sch3 C (CH3) 2ch2sch3 C(CH3)2CH2SCH3 C(CH3)2CH2SCH3 C(CH3) 2ch2sch3 C(CH3) 2ch2sch3 c(ch3)2ch2sch3 C(CH3)2CH2SCH3 C(CH3)2CH2SCH3 C(CH3) 2ch2sch3 C(CH3)2CH2SCH3 C(CH3)2CH2SCH3 C(CH3)2CH2SCH3 c(ch3)2ch2sch3 c(ch3)2ch2sch3 c(ch3)2ch2sch3 C(CH3)2CH2SCH3 c(ch3) 2ch2sch3 ch3 cfcicf2ci Ph-4-Cl ch3 CF2CF2Br Ph-4-Cl ch3 CFBrCF3 Ph-4&gt;C1 CH3 cf2cf2cf3 Ph-4-Cl ch3 cf(cf3)2 Ph-4-Cl ch3 cf2cfcicf2ci Ph+Cl ch3 T-1 H ch3 T- 2 H ch3 T-3 H ch3 T-4 H ch3 T-5 H ch3 CF2CF2CF2CF3 Ph-4-Cl ch3 cf2cf2cf2chf2 Ph-4-Cl ch3 CF (CF3)CF2CF3 Ph+Cl ch3 cf2cf2cf2cf2ci Ph+Cl ch3 CF 2 CF 2 CF 2 CF 2 CF 2 CF 3 Ph-4-Cl ch3 ch2och3 H ch3 ch2och3 ch3 ch3 ch2och3 Et ch3 ch2och3 n-Pr ch3 ch2och3 i-Pr ch3 ch2och3 Ph~4~F ch3 ch2och3 Ph+Cl ch3 ch2och3 Ph-4-Br ch3 ch2och3 Ph-4-CF3 ch3 ch2och3 Ph-4-0CHF ch3 ch2och3 Ph-4-0CF3 ch3 CH2OEt H ch3 CH2OEt Ph-4-F ch3 CH2OEt Ph-4~C1 ch3 CH2OEt Ph-4-Br ch3 CH2OEt Ph-4-CF3 ch3 CH2OEt Ph-4-0CHF ch3 CH2OEt Ph~4-0CF3 ch3 CH2OCH2CF3 H ch3 ch2och2cf3 ch3 ch3 ch2och2cf3 Et 2 2 451
314918 200407073 Η C(CH3)2CH2SCH3 ch3 ch2och2cf3 n-Pr Η c(ch3)2ch2sch3 ch3 ch2och2cf3 i，Pr Η c(ch3)2ch2sch3 ch3 ch2och2cf3 Ph-4-F Η C(CH3)2CH2SCH3 ch3 ch2och2cf3 Ph+Cl Η c(ch3)2ch2sch3 ch3 ch2och2cf3 Ph-4~Br Η c(ch3)2ch2sch3 ch3 ch2och2cf3 Ph-4-CF3 Η C(CH3)2CH2SCH3 ch3 ch2och2cf3 Ph-4-0CHF Η C(CH3)2CH2SCH3 ch3 ch2och2cf3 Ph-4-0CF3 Η c(ch3)2ch2sch3 ch3 ch2och2cf2cf3 H Η C(CH3)2CH2SCH3 ch3 ch2och2cf2cf3 ch3 Η c(ch3)2ch2sch3 ch3 ch2och2cf2cf3 Et Η c(ch3)2ch2sch3 ch3 ch2och2cf2cf3 n-Pr Η C(CH3)2CH2SCH3 ch3 ch2och2cf2cf3 i-Pr Η C(CH3)2CH2SCH3 ch3 ch2och2cf2cf3 Ph~*4-F Η C(CH3)2CH2SCH3 ch3 ch2och2cf2cf3 Ph-4-Cl Η c(ch3)2ch2sch3 ch3 ch2och2cf2cf3 Ph+Br Η c(ch3)2ch2sch3 ch3 ch2och2cf2cf3 Pb-4-CF3 Η C(CH3)2CH2SCH3 ch3 ch2och2cf2cf3 Ph-4-0CHF Η C(CH3)2CH2SCH3 ch3 ch2〇ch2cf2cf3 Ph-4-0CF3 Η c(ch3)2ch2sch3 ch3 cf2ocf2cf2ocf3 H Η C(CH3)2CH2SCH3 ch3 CF (CF3)〇CF2CF2CF3 H Η C(CH3)2CH2SCH3 ch3 ch2sch3 H Η C(CH3)2CH2SCH3 ch3 ch2sch3 Ph+Cl Η c(ch3)2ch2sch3 ch3 ch2sch3 Ph-4-0CF3 Η c(ch3)2ch2sch3 ch3 ch2so2ch3 H Η C(CH3)2CH2SCH3 ch3 ch2so2ch3 Ph+Cl Η C(CH3)2CH2SCH3 ch3 ch2so2ch3 Ph~4~0CF 3 Η C(CH3)2CH2SCH3 ch3 CH2SEt H Η c(ch3)2ch2sch3 ch3 CH2SEt Ph+Cl Η C(CH3)2CH2SCH3 ch3 CH2SEt Ph-4-0CF3 Η C(CH3)2CH2SCH3 ch3 ch2scf3 H Η c(ch3)2ch2sch3 ch3 ch2scf3 PH-Cl Η c(ch3)2ch2sch3 ch3 ch2scf3 ph-ocf3 Η C(CH3)2CH2SCH3 ch3 CH2SPh H Η c(ch3)2ch2sch3 ch3 CH2SPh Ph+Cl Η c(ch3)2ch2sch3 ch3 och3 H Η c(ch3)2ch2sch3 ch3 och3 ch3
452 314918 200407073
Η C(CH3)2CH2SCH3 ch3 och3 Et Η C(CH3)2CH2SCH3 ch3 och3 n-Pr Η C(CH3)2CH2SCH3 ch3 och3 i-Pr Η c(ch3&gt;2ch2sch3 ch3 och3 Ph~4~F Η c(ch3)2ch2sch3 ch3 och3 Ph+Cl Η c(ch3)2ch2sch3 ch3 och3 Ph-4-Br Η c(ch3)2ch2sch3 ch3 och3 Ph-4-CF 3 Η C(CH3)2CH2SCH3 ch3 och3 Ph-4-OCHF Η c(ch3)2ch2sch3 ch3 och3 Ph-4-0CF3 Η c(ch3)2ch2sch3 ch3 so2cf3 H Η C(CH3)2CH2SCH3 ch3 so2cf3 ch3 Η c(ch3)2ch2sch3 ch3 so2cf3 Et Η C(CH3)2CH2SCH3 ch3 so2cf3 n-Pr Η C(CH3)2CH2SCH3 ch3 so2cf3 卜Pr Η c(ch3)2ch2sch3 ch3 so2cf3 Ph-4-F Η C(CH3)2CH2SCH3 ch3 so2cf3 Ph-4-Cl Η C(CH3)2CH2SCH3 ch3 so2cf3 Ph~4~Br Η C(CH3)2CH2SCH3 ch3 so2cf3 Ph-4-CF 3 Η C(CH3)2CH2SCH3 ch3 SO 2 CF 3 Ph-4-0CHF Η C(CH3)2CH2SCH3 ch3 SO 2 CF 3 Ph-4-0CF 3 Η C(CH3)2CH2SCH3 ch3 SPh H Η C(CH3)2CH2SCH3 ch3 SPh ch3 Η C(CH3) 2ch2sch3 ch3 SPh Et Η C(CH3)2CH2SCH3 ch3 SPh n-Pr Η c(ch3)2ch2sch3 ch3 SPh i-Pr Η C(CH3)2CH2SCH3 ch3 SPh Ph-4-Cl Η C(CH3)2CH2SCH3 ch3 T - 22 H Η c(ch3) 2ch2sch3 ch3 T - 23 H Η C(CH3)2CH2SCH3 ch3 T-24 H Η c(ch3)2ch2sch3 ch3 Ph H Η C(CH3)2CH2SCH3 ch3 Ph-4-F H Η C(CH3)2CH2SCH3 ch3 Ph，4-Cl H Η C(CH3)2CH2SCH3 ch3 Ph-4-Br H Η c(ch3)2ch2sch3 ch3 Ph-4-1 H Η c(ch3)2ch2sch3 ch3 Ph-4-CH3 H Η c(ch3)2ch2sch3 ch3 Ph~4*~Bu~t H Η c(ch3)2ch2sch3 ch3 Ph-4-CF3 H
453 314918 200407073
Η C(CH3) 2ch2sch3 ch3 Ph-4-CH20CH2CF3 H Η c(ch3)2ch2sch3 ch3 Ph-4-C (CF3) 2〇H H Η c(ch3) 2ch2sch3 ch3 Ph+CH2SCH3 H Η c(ch3)2ch2sch3 ch3 Ph - 4-CH2S (0&gt; CH3 H Η c(ch3)2ch2sch3 ch3 Ph - 4-CH2S02CH3 H Η c(ch3)2ch2sch3 ch3 Ph-4-CH2SCF3 H Η c(ch3)2ch2sch3 ch3 Ph-4~CH2S(0) CF3 H Η C(CH3)2CH2SCH3 ch3 Ph-4-CH2S02CF3 H Η c(ch3)2ch2sch3 ch3 Ph-4-0CH3 H Η C(CH3)2CH2SCH3 ch3 Ph-4-OPr-i H Η C (CH3) 2ch2sch3 ch3 Ph-4-0CHF2 H Η c(ch3) 2ch2sch3 ch3 Ph-4-OCFs H Η c(ch3)2ch2sch3 ch3 Ph-4-0CF2Br H Η c(ch3)2ch2sch3 ch3 Ph+0CH2CF3 H Η c(ch3)2ch2sch3 ch3 Ph-4-0CF2CHF2 H Η C(CH3)2CH2SCH3 ch3 Ph-4-0CF2CHFCl H Η C(CH3)2CH2SCH3 ch3 Ph-4-0CF2CHFBr H Η c(ch3)2ch2sch3 ch3 Ph-4-0CF2CF2Br H Η c(ch3)2ch2sch3 ch3 Ph-4-0CF2CFCl2 H Η C(CH3)2CH2SCH3 ch3 Ph-4-0CF2CCl3 H Η c(ch3)2ch2sch3 ch3 Ph-4-0CH2CF2CHF2 H Η C(CH3) 2ch2sch3 ch3 Ph-4-0CF2CHFCF3 H Η C(CH3)2CH2SCH3 ch3 Ph-4-0CH(CF3)2 H Η c(ch3) 2ch2sch3 ch3 Ph-4-0CF2CFBrCF3 H Η C(CH3)2CH2SCH3 ch3 Ph-4-0CF2CHFOCF3 H Η C(CH3)2CH2SCH3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 H Η c(ch3) 2ch2sch3 ch3 Ph-4-0S02CH3 H Η c(ch3)2ch2sch3 ch3 Ph-4-0S02CF3 H Η C(CH3)2CH2SCH3 ch3 Ph-4-0(Ph-4-CF3) H Η C(CH3)2CH2SCH3 ch3 Ph-3-0(L-45g) H Η C(CH3)2CH2SCH3 ch3 Ph-4-0 (L-45g) H Η C(CH3)2CH2SCH3 ch3 Ph - 4-0(L-451) H Η c(ch3)2ch2sch3 ch3 Ph-4-SCH3 H Η c(ch3)2ch2sch3 ch3 Ph+S (0) CH3 H Η C(CH3) 2ch2sch3 ch3 Ph+S02CH3 H Η c(ch3)2ch2sch3 ch3 Ph-4-SCF3 H Η c(ch3)2ch2sch3 ch3 Ph+S(0)CF3 H
454 314918 200407073
Η C(CH3)2CH2SCH3 ch3 Ph-4-S02CF3 H Η c(ch3)2ch2sch3 ch3 Ph-4-N02 H Η c(ch3)2ch2sch3 ch3 Ph-4-N (CH3) 2 H Η C(CH3)2CH2SCH3 ch3 Ph-4-CN H Η c(ch3)2ch2sch3 ch3 Ph+C ⑼ NH2 H Η C(CH3)2CH2SCH3 ch3 Ph-4-C ⑸ NH2 H Η C(CH3)2CH2SCH3 ch3 Ph-3, 4-F2 H Η C(CH3)2CH2SCH3 ch3 Ph-3-F-4-Cl H Η c(ch3)2ch2sch3 ch3 Ph-3, 4-Cl2 H Η C(CH3)2CH2SCH3 ch3 Ph-3~F-4~CF 3 H Η c(ch3)2ch2sch3 ch3 Ph-3-F-4-0CHF2 H Η C(CH3)2CH2SCH3 ch3 Ph-3-C卜4-0CHF2 H Η c(ch3)2ch2sch3 ch3 Ph-3-F-4-0CF3 H Η c(ch3)2ch2sch3 ch3 Ph-3-C卜4-0CF3 H Η C(CH3) 2ch2sch3 ch3 Ph-3~F~4-OCF 2 B r H Η C(CH3)2CH2SCH3 ch3 2-Naph H Η c(ch3)2ch2sch3 ch3 L-lb H Η C(CH3)2CH2SCH3 ch3 L-lc H Η c(ch3)2ch2sch3 ch3 L，ld H Η C{CH3)2CH2SCH3 ch3 L-le H Η C(CH3) 2ch2sch3 ch3 L-li H Η C(CH3)2CH2SCH3 ch3 L-2b H Η C(CH3)2CH2SCH3 ch3 L - 3c H Η C(CH3)2CH2SCH3 ch3 L-3d H Η c(ch3)2ch2sch3 ch3 L-3e H Η C(CH3)2CH2SCH3 ch3 L~3f H Η C(CH3)2CH2SCH3 ch3 L-3j H Η c(ch3)2ch2sch3 ch3 L-3k H Η c《ch3&gt;2ch2sch3 ch3 L-31 H Η C(CH3)2CH2SCH3 ch3 L-4b H Η C(CH3)2CH2SCH3 ch3 L - 4c H Η c(ch3)2ch2sch3 ch3 L-6d H Η C(CH3)2CH2SCH3 ch3 L-6e H Η C(CH3)2CH2SCH3 ch3 L-lOb H Η C(CH3)2CH2SCH3 ch3 L-lOc H Η c(ch3)2ch2sch3 ch3 L - 16a H Η c(ch3)2ch2sch3 ch3 L-16b H
455 314918 200407073 Η C(CH3)2CH2SCH3 ch3 L - 17a H Η C(CH3)2CH2SCH3 ch3 L-21b H Η C(CH3)2CH2SCH3 ch3 L- 21c H Η C(CH3)2CH2SCH3 ch3 L-21d H Η C(CH3)2CH2SCH3 ch3 L~21e H Η C(CH3)2CH2SCH3 ch3 L-22b H Η C(CH3)2CH2SCH3 ch3 L - 22c H Η C(CH3)2CH2SCH3 ch3 L-23b H Η C(CH3)2CH2SCH3 ch3 L-23c H Η C(CH3)2CH2SCH3 ch3 L - 23f H Η c(ch3)2ch2sch3 ch3 L~23g H Η c(ch3&gt;2ch2sch3 ch3 L*-31a H Η C(CH3)2CH2SCH3 ch3 L-31b H Η C(CH3)2CH2SCH3 ch3 L - 45d H Η C(CH3)2CH2SCH3 ch3 L-45e H Η C(CH3)2CH2SCH3 ch3 L-45f H Η C(CH3)2CH2SCH3 ch3 L - 45g H Η C(CH3)2CH2SCH3 ch3 L~45m H Η C(CH3)2CH2SCH3 ch3 L - 46d H Η C(CH3)2CH2SCH3 ch3 L-46e H Η C(CH3)2CH2SCH3 ch3 L~46f H Η c(ch3&gt;2ch2sch3 ch3 L - 46g H Η C(CH3)2CH2SCH3 ch3 L - 46j H Η c(ch3)2ch2sch3 ch3 L - 46k H Η C(CH3)2CH2SCH3 ch3 L - 46d H Η c(ch3)2ch2sch3 ch3 L - 46r H Η C(CH3)2CH2SCH3 ch3 L - 47a H Η C(CH3)2CH2SCH3 ch3 L - 47e H Η C(CH3)2CH2SCH3 ch3 L-50b H Η C(CH3)2CH2SCH3 ch3 L-50c H Η C(CH3)2CH2SCH3 ch3 L-50d H Η C(CH3)2CH2SCH3 ch3 L_51b H Η C(CH3)2CH2SCH3 Et cf3 PH-Cl Η C(CH3)2CH2SCH3 Et Ph-4-0CF3 H Η c(ch3)2ch2sch3 ch2oh cf3 Ph-4-Cl Η c(ch3)2ch2sch3 ch2oh Ph-4_0CF3 H Η c(ch3) 2ch2sch3 och3 cf3 Ph+Cl
456 314918 200407073 Η C(CH3)2CH2SCH3 och3 PH - 0CF3 H Η c(ch3)2ch2sch3 sch3 cf3 Ph-4-Cl Η C(CH3)2CH2SCH3 sch3 Ph+0CF3 H Η c(ch3)2ch2s(o)ch3 F cf3 Ph-4-Cl Η C(CH3)2CH2S(0) ch3 F Ph-4-0CF3 H Η C(CH3)2CH2S(0) ch3 Cl cf3 Ph-4~F Η C(CH3)2CH2S(0) ch3 Cl cf3 Ph-4-Cl Η C(CH3)2CH2S(0) ch3 Cl cf3 Ph+Br Η C(CH3)2CH2S(0)CH3 Cl cf3 Ph-4-CF3 Η C(CH3) 2CH2S(0) ch3 Cl cf3 Ph-4-0CHF2 Η C(CH3)2CH2S(0)CH3 Cl cf3 Ph-4-OCFa Η C(CH3)2CH2S(0) ch3 Cl cf3 Ph-3, 4-C12 Η C(CH3)2CH2S(0) ch3 Cl Ph-4-F H Η C(CH3)2CH2S(0)CH3 Cl Ph-4-Cl H Η C(CH3)2CH2S(0)CH3 Cl Ph~4~Br H Η c(ch3)2ch2s(o)ch3 Cl Ph-4-CF3 H Η C(CH3)2CH2S(0) ch3 Cl Ph-4-0CHF2 H Η C(CH3)2CH2S(0) ch3 Cl Ph-4-0CF3 H Η C(CH3)2CH2S(0) ch3 Cl Ph-4-0 (L-45g) H Η C(CH3)2CH2S(0) ch3 Cl Ph-3,4-Cl2 H Η C(CH3)2CH2S(0)CH3 Br cf3 Ph-4-Cl Η c(ch3)2ch2s(o)ch3 Br Ph+0CF3 H Η C(CH3)2CH2S(0) ch3 ch3 F Ph-4-F Η C(CH3)2CH2S(0) ch3 ch3 F Ph+Cl Η C(CH3)2CH2S(0) ch3 ch3 F Ph~4~Br Η c(ch3)2ch2s(o)ch3 ch3 F Ph-4-CF3 Η C(CH3)2CH2S(0) ch3 ch3 F Ph-4-0CHF2 Η C(CH3)2CH2S(0) ch3 ch3 F Ph-4~0CF 3 Η c(ch3)2ch2s(o)ch3 ch3 F Ph-3, 4-Cl2 Η c(ch3)2ch2s(o)ch3 ch3 Cl Ph-4-F Η C(CH3)2CH2S(0)CH3 ch3 Cl Ph+Cl Η C(CH3)2CH2S(0) ch3 ch3 Cl Ph+Br Η C(CH3)2CH2S(0) ch3 ch3 Cl Ph+I Η C(CH3)2CH2S(0) ch3 ch3 Cl Ph-4-CF3 Η C(CH3)2CH2S(0)CH3 ch3 Cl Ph-4-0CHF2 Η C(CH3) 2CH2S(0) ch3 ch3 Cl Ph-4-0CF3 Η C(CH3) 2CH2S(0) ch3 ch3 Cl Ph-4~0CF2Br
457 314918 200407073 Η c(ch3)2ch2s(o)ch3 ch3 Cl Ph-4-0CF2CHF2 Η C(CH3) 2CH2S(0) ch3 ch3 Cl Ph-4-0CF2CHFC1 Η C(CH3)2CH2S(0) ch3 ch3 Cl Ph-4~0CF2CHFCF3 Η c(ch3)2ch2s(o)ch3 ch3 Cl Ph-4-0CF2CHF0CF Η C(CH3)2CH2S(0) ch3 ch3 Cl Ph-4-0 (L-45g) Η C(CH3)2CH2S(0)CH3 ch3 Cl Ph-3,4_C12 Η C(CH3)2CH2S(0) ch3 ch3 Br Ph一4_f Η C(CH3)2CH2S(0) ch3 ch3 Br Ph-4-Cl Η C(CH3)2CH2S(0) ch3 ch3 Br Ph-4-Br Η c(ch3)2ch2s(o)ch3 ch3 Br Ph-4-CF3 Η c(ch3)2ch2s(o)ch3 ch3 Br Ph-4-0CHF2 Η C(CH3)2CH2S(0) ch3 ch3 Br Ph-4-0CF3 Η C(CH3) 2CH2S(0) ch3 ch3 Br Ph-3,4_C12 Η c(ch3)2ch2s(o)ch3 ch3 ch3 Ph-4-F Η C(CH3)2CH2S(0) ch3 ch3 ch3 Ph-4-Cl Η C(CH3)2CH2S(0) ch3 ch3 ch3 Ph-4-Br Η C(CH3)2CH2S(0)CH3 ch3 ch3 Ph-4-CF3 Η C(CH3)2CH2S(0) ch3 ch3 ch3 Ph-4-0CHF2 Η C(CH3)2CH2S(0) ch3 ch3 ch3 Ph-4-0CF3 Η C(CH3)2CH2S(0) ch3 ch3 ch3 Ph-4-0CF2Br Η C(CH3) 2CH2S(0) ch3 ch3 ch3 Ph-4~0CF2CHFCF3 Η C(CH3)2CH2S(0)CH3 ch3 ch3 Ph-3,4HF2 Η C(CH3)2CH2S(0) ch3 ch3 ch3 Ph-3-F-4-C1 Η C(CH3) 2CH2S(0) ch3 ch3 ch3 Ph-3, 4-Cl2 Η C(CH3)2CH2S(0) ch3 ch3 ch3 L - 46d Η C(CH3)2CH2S(0) ch3 ch3 Et Ph-4-F Η C(CH3) 2CH2S(0) ch3 ch3 Et Ph-4-Cl Η C(CH3) 2CH2S(0) ch3 ch3 Et Ph~4~Br Η c(ch3)2ch2s«»ch3 ch3 Et Ph+CF3 Η C(CH3)2CH2S(0) ch3 ch3 Et Ph-4-0CHF2 Η C(CH3)2CH2S (0) ch3 ch3 Et Ph-4-OCF 3 Η c(ch3)2ch2s(o)ch3 ch3 Et Ph-3, 4-Cl2 Η c(ch3)2ch2s(o)ch3 ch3 c-Pr H Η C(CH3)2CH2S(0) ch3 ch3 chf2 Ph-4-F Η C(CH3)2CH2S(0)CH3 ch3 chf2 Ph+Cl Η c(ch3)2ch2s(o)ch3 ch3 chf2 Ph-4-Br Η c(ch3)2ch2s(o)ch3 ch3 chf2 Ph+CF3
458 314918 200407073 ch3 chf2 ch3 chf2 ch3 chf2 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf3 ch3 cf2ci ch3 cf2ci ch3 cf2ci ch3 cf2ci ch3 cf2ci ch3 cf2ci ch3 cf2ci ch3 CF2Br ch3 cf2cf3 ch3 cf2cf3 ch3 cf2cf3 ch3 cf2cf3 ch3 cf2cf3 ch3 cf2cf3 ch3 cf2cf3 ch3 cf2cf2cf3 ch3 ch2och2cf3 ch3 ch2och2cf3 H C(CH3) 2CH2S_3 H C(CH3) 2CH2S(0) CH3 H C(CH3)2CH2S(0)CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3)2CH2S(0)CH3 H C(CH3)2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3)2CH2S(0)CH3 H C(CH3)2CH2S(0) CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3)2CH2S(0)CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3)2CH2S(0)CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0)CH3 H C(CH3)2CH2S(0)CH3 H C(CH3)2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3) 2CH2S(0)CH3 H C(CH3)2CH2S_3 H C(CH3) 2CH2S(0)CH3 H C(CH3)2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3
Ph-4-0CHF2
Ph-4_0CF3
Ph-3, 4-Cl2
Ph-4-F
Ph+Cl
Ph+Br
Ph+I
Ph+CF3
Ph-4-0CHF2
Ph-4-0CF3
Ph-4-0CF2Br
Ph~4-0CF2CHF2
Ph-4-0CF2CHFCl
Ph-4-0CF2CHFCF3
Ph-4-0CF2CHF0CF3
Ph-4-0CF2CHF0CF2CF2CF
Ph-3, 4-F2
Ph-3-F-4-Cl
Ph-3. 4-Cl2
Ph-4-F
Ph+Cl
Ph-4-Br
Ph-4-CF3
Ph-4-0CHF2
Ph-4-0CF3
Ph~3, 4~C 12
Ph-4«C1
Ph-4-F
Ph+Cl
Ph~4~Br
Ph+CF3
Ph-4-0CHF2
Ph+0CF3
Ph-3, 4-Cl2
Ph-4-Cl
H CH3
459 314918 200407073
Η c(ch3)2ch2s(o)ch3 ch3 ch2och2cf3 Et Η C(CH3)2CH2S(0) ch3 ch3 ch2och2cf3 n-Pr Η C(CH3)2CH2S(0) ch3 ch3 ch2och2cf3 i-Pr Η C(CH3)2CH2S(0) ch3 ch3 ch2och2cf3 PH-C1 Η C(CH3)2CH2S(0) ch3 ch3 ch2och2cf2cf3 H Η C(CH3)2CH2S(0) ch3 ch3 ch2och2cf2cf3 ch3 Η c(ch3)2ch2s(o)ch3 ch3 ch2och2cf2cf3 Ph+Cl Η c(ch3)2ch2s(o)ch3 ch3 cf2ocf2cf2ocf3 H Η C(CH3)2CH2S(0) ch3 ch3 CF (CF3)〇CF2CF2CF3 H Η C(CH3)2CH2S(0) ch3 ch3 ch2scf3 H Η C(CH3)2CH2S(0) ch3 ch3 ch2scf3 Ph+Cl Η C(CH3)2CH2S(0) ch3 ch3 S02CF3 H Η C(CH3)2CH2S(0) ch3 ch3 T-22 H Η C(CH3)2CH2S(0) ch3 ch3 T-23 H Η C(CH3)2CH2S(0)CH3 ch3 T-24 H Η C(CH3)2CH2S(0) ch3 ch3 Ph-4-F H Η C(CH3)2CH2S(0) ch3 ch3 Ph-4-Cl H Η c(ch3)2ch2s&lt;o)ch3 ch3 Ph-4-Br H Η C(CH3)2CH2S(0)CH3 ch3 PH -1 H Η C(CH3)2CH2S(0) ch3 ch3 Ph-4-CF3 H Η C(CH3)2CH2S(0) ch3 ch3 Ph-4-0CHF2 H Η C(CH3)2CH2S(0) ch3 ch3 Ph-4~0CF3 H Η C(CH3)2CH2S (0) ch3 ch3 Ph-4-0CF2Br H Η c(ch3)2ch2s(o)ch3 ch3 Ph-4-0CF2CHF2 H Η c(ch3)2ch2s«kh3 ch3 Ph-4-0CF2CHFCl H Η C(CH3)2CH2S(0) ch3 ch3 Ph-4-0CF2CHFCF3 H Η c(ch3)2ch2s(o)ch3 ch3 Ph-4-0CF2CHF0CF3 H Η C(CH3)2CH2S(0) ch3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 H Η c(ch3)2ch2s(o)ch3 ch3 Ph+0 (Ph+CF3) H Η C(CH3)2CH2S(0) ch3 ch3 Ph-4~0 (L-45g) H Η C(CH3)2CH2S(0) ch3 ch3 Ph-4-SCF3 H Η c(ch3)2ch2s(o)ch3 ch3 Ph-4-CN H Η c(ch3)2ch2s(o)ch3 ch3 Ph-4-C (0) NH2 H Η C(CH3)2CH2S(0) ch3 ch3 Ph-4-C ⑸ NH2 H Η C(CH3)2CH2S(0) ch3 ch3 Ph~3, 4~F2 H Η C(CH3)2CH2S(0) ch3 ch3 Ph-3-F-4-Cl H Η C(CH3)2CH2S(0) ch3 ch3 Ph-3, 4-Cl2 H
460 314918 200407073 H C(CH3)2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0)CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0)CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S (0) CH3 H C(CH3)2CH2S(0)CH3 H C(CH3)2CH2S(0)CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0)CH3 H C(CH3)2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0)CH3 H C(CH3)2CH2S(0) CH3
gh3 L-lb H ch3 L - lc H ch3 L-ld H ch3 L - le H ch3 L- li H ch3 L - 2b H ch3 L-3b H ch3 L - 3c H ch3 L-3d H ch3 L_3e H ch3 L-3f H ch3 L-3k H ch3 L~31 H ch3 L~3o H ch3 L - 4b H ch3 L-4c H ch3 L-lOb H ch3 L- 10c H ch3 L-16a H ch3 L-16b H ch3 L-21b H ch3 L~21c H ch3 L-21d H ch3 L-21e H ch3 l-22b H ch3 L-22c H ch3 L - 23b H ch3 L-23c H ch3 L-31a H ch3 L，31b H ch3 L-45c H ch3 L-45d H ch3 L-45e H ch3 L，45f H ch3 L-45g H ch3 L-451 H ch3 L-45in H 461 314918 200407073 Η C(CH3) 2CH2S(0) ch3 ch3 L - 46c H Η C(CH3) 2CH2S(0) ch3 ch3 L - 46d H Η C(CH3)2CH2S(0) ch3 ch3 L-46e H Η c(ch3)2ch2s(o)ch3 ch3 L - 46f H Η C(CH3)2CH2S(0)CH3 ch3 L_46g H Η c(ch3)2ch2s(o)ch3 ch3 L-46j H Η C(CH3)2CH2S(0) ch3 ch3 L-46k H Η C(CH3)2CH2S(0) ch3 ch3 L-46r H Η c(ch3)2ch2s(o)ch3 ch3 L - 47a H Η C(CH3)2CH2S(0) ch3 ch3 L-47e H Η c(ch3)2ch2s(o)ch3 ch3 L-50b H Η C(CH3)2CH2S(0) ch3 ch3 L - 50c H Η C(CH3) 2CH2S(0) ch3 ch3 L-50d H Η c(ch3)2ch2s(o)ch3 ch3 L-51b H Η C(CH3)2CH2S02CH3 F cf3 Ph+Cl Η C(CH3)2CH2S02CH3 F Ph-4-0CF3 H Η c(ch3)2ch2so2ch3 Cl cf3 Ph_4，F Η c(ch3)2ch2so2ch3 Cl cf3 Ph-4-Cl Η c(ch3)2ch2so2ch3 Cl cf3 Ph-4-Br Η c(ch3)2ch2so2ch3 Cl cf3 Ph-4-CF3 Η C(CH3)2CH2S02CH3 Cl cf3 Ph-4-0CHF Η C(CH3) 2ch2so2ch3 Cl cf3 Ph-4-0CF3 Η c&lt;ch3)2ch2so2ch3 Cl cf3 Ph-3, 4-Cl Η c(ch3)2ch2so2ch3 Cl Ph-4-F H Η C(CH3) 2ch2so2ch3 Cl Pb-4-Cl H Η C(CH3)2CH2S02CH3 Cl Ph+Br H Η c(ch3)2ch2so2ch3 Cl Ph-4-CF3 H Η C(CH3) 2ch2so2ch3 Cl Ph-4-0CHF2 H Η C(CH3) 2ch2so2ch3 Cl Ph-4-0CF3 H Η C(CH3)2CH2S02CH3 Cl Ph-4-0 (L-45g) H Η C(CH3)2CH2S02CH3 Cl Ph-3,4-Cl2 H Η C(CH3)2CH2S02CH3 Br cf3 Ph-4-Cl Η c(ch3)2ch2so2ch3 Br Ph-4-0CF3 H Η C(CH3)2CH2S02CH3 ch3 F Ph-4-F Η c(ch3)2ch2so2ch3 ch3 F Ph-4-Cl Η C(CH3) 2ch2so2ch3 ch3 F Ph~4_Br Η C(CH3)2CH2S02CH3 ch3 F Ph+CF3
462 314918 200407073 Η c(ch3)2ch2so2ch3 ch3 F Ph-4-0CHF2 Η c(ch3)2ch2so2ch3 ch3 F Ph-4~0CF 3 Η C(CH3)2CH2S02CH3 ch3 F Ph-3, 4-Cl2 Η c(ch3)2ch2so2ch3 ch3 Cl Ph-4-F Η c(ch3)2ch2so2ch3 ch3 Cl Ph-4-Cl Η c(ch3)2ch2so2ch3 ch3 Cl Ph-4-Br Η C(CH3)2CH2S02CH3 ch3 Cl Ph-4-I Η c(ch3)2ch2so2ch3 ch3 Cl Ph-4-CF3 Η c(ch3)2ch2so2ch3 ch3 Cl Ph-4»0CHF2 Η C(CH3)2CH2S02CH3 ch3 Cl Ph-4-0CF3 Η C(CH3)2CH2S02CH3 ch3 Cl Ph-4-0CF2Br Η C(CH3)2CH2S02CH3 ch3 Cl Ph-4-0CF2CHF2 Η C(CH3)2CH2S02CH3 ch3 Cl Ph-4-0CF2CHFCl Η c(ch3)2ch2so2ch3 ch3 Cl Ph-4-0CF2CHFCF3 Η C(CH3)2CH2S02CH3 ch3 Cl Ph-4-0CF2CHF0CF Η c(ch3)2ch2so2ch3 ch3 Cl Ph-4-0 (L-45g) Η C(CH3)2CH2S02CH3 ch3 Cl Ph-3, 4-Cl2 Η C(CH3)2CH2S02CH3 ch3 Br Ph-4-F Η C(CH3)2CH2S02CH3 ch3 Br Ph-4-C1 Η C(CH3)2CH2S02CH3 ch3 Br Ph-4-Br Η C(CH3)2CH2S02CH3 ch3 Br Ph-4-CF3 Η C(CH3)2CH2S02CH3 ch3 Br Ph-4-0CHF2 Η c(ch3)2ch2so2ch3 ch3 Br Ph-4-0CF3 Η C(CH3)2CH2S02CH3 ch3 Br Ph-3,4-Cl2 Η C(CH3) 2ch2so2ch3 ch3 ch3 Ph-4，F Η C(CH3)2CH2S02CH3 ch3 ch3 Ph+Cl Η C(CH3)2CH2S02CH3 ch3 ch3 Ph-4-Br Η C(CH3)2CH2S02CH3 ch3 ch3 Ph+I Η c(ch3)2ch2so2ch3 ch3 ch3 Ph-4-CF3 Η C(CH3)2CH2S02CH3 ch3 ch3 Ph-4-0CHF2 Η C(CH3)2CH2S02CH3 ch3 ch3 Ph-4-0CF3 Η C(CH3)2CH2S02CH3 ch3 ch3 Ph-4-0CF2Br Η c(ch3)2ch2so2ch3 ch3 ch3 Ph-4-0CF2CHFCF3 Η c(ch3)2ch2so2ch3 ch3 ch3 Ph-3, 4-F2 Η C(CH3)2CH2S02CH3 ch3 ch3 Ph-3-F_4-C1 Η C(CH3)2CH2S02CH3 ch3 ch3 Ph-3, 4-Cl2 Η C(CH3)2CH2S02CH3 ch3 ch3 L-46d
463 314918 200407073 Η C(CH3) 2ch2so2ch3 ch3 Et Ph~4-F Η c(ch3)2ch2so2ch3 ch3 Et Ph-4-Cl Η c(ch3) 2ch2so2ch3 ch3 Et Ph-4-Br Η C(CH3)2CH2S02CH3 ch3 Et Ph-4-CF3 Η c(ch3)2ch2so2ch3 ch3 Et Ph-4-0CHF2 Η c(ch3) 2ch2so2ch3 ch3 Et Ph-4-0CF3 Η c(ch3)2ch2so2ch3 ch3 Et Ph-3, 4-Cl 2 Η c(ch3)2ch2so2ch3 ch3 n-Pr Ph-4-Cl Η c(ch3)2ch2so2ch3 ch3 i-Pr Ph_4-Cl Η c(ch3)2ch2so2ch3 ch3 c - Pr H Η C(CH3)2CH2S02CH3 ch3 c-Pr Ph-4-Cl Η C(CH3) 2ch2so2ch3 ch3 n-Bu Ph+Cl Η C(CH3) 2ch2so2ch3 ch3 chf2 Ph-4-F Η C(CH3) 2ch2so2ch3 ch3 chf2 Ph-4-Cl Η C(CH3) 2ch2so2ch3 ch3 chf2 Ph-4-Br Η c(ch3)2ch2so2ch3 ch3 chf2 Ph-4-CF3 Η C(CH3) 2ch2so2ch3 ch3 chf2 Ph-4-0CHF2 Η c(ch3)2ch2so2ch3 ch3 chf2 Ph-4-0CF3 Η C(CH3)2CH2S02CH3 ch3 chf2 Ph- 3,4-Cl2 Η C(CH3) 2ch2so2ch3 ch3 cf3 Η C(CH3)2CH2S02CH3 ch3 cf3 PH-Cl Η C(CH3) 2ch2so2ch3 ch3 cf3 Ph~4~Br Η C(CH3) 2ch2so2ch3 ch3 cf3 Ph+I Η C(CH3) 2ch2so2ch3 ch3 cf3 Ph-4-CF3 Η c(ch3)2ch2so2ch3 ch3 cf3 Ph-4-0CHF2 Η c(ch3)2ch2so2ch3 ch3 cf3 Ph-4-0CF3 Η c(ch3) 2ch2so2ch3 ch3 cf3 Ph-4-0CF2Br Η C(CH3) 2ch2so2ch3 ch3 cf3 Ph-4-0CF2CHF2 Η c(ch3)2ch2so2ch3 ch3 cf3 Ph-4-0CF2CHFCl Η C(CH3)2CH2S02CH3 ch3 cf3 Ph-4-0CF2CHFCF3 Η C(CH3)2CH2S02CH3 ch3 cf3 Ph-4-0CF2CHF0CF3 Η c(ch3)2ch2so2ch3 ch3 cf3 Ph-4-0CF2CHF0CF2CF2CF3 Η C(CH3) 2ch2so2ch3 ch3 cf3 Ph-3, 4-F2 Η c (CH3) 2ch2so2ch3 ch3 cf3 Ph~3~F~4-Cl Η c(ch3)2ch2so2ch3 ch3 cf3 Ph-3,4-Cl2 Η c(ch3)2ch2so2ch3 ch3 cf3 L~lb Η C(CH3) 2ch2so2ch3 ch3 cf3 L_lc
464 314918 200407073 H C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02GH3 Η C《CH3&gt;2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 Η C(CH3)2CH2S02CH3 ch3 cf3 L-ld ch3 cf3 L-le ch3 cf3 L-li ch3 cf3 L - 2b ch3 cf3 L - 3c ch3 cf3 L-3d ch3 cf3 L_3e ch3 gf3 L-3i ch3 cf3 L_3j ch3 cf3 L-3k ch3 cf3 L-31 ch3 cf3 L - 3o ch3 cf3 L-4b ch3 cf3 L-4c ch3 cf3 L - 4e ch3 cf3 L-lOb ch3 cf3 L-lOc ch3 cf3 L-21b ch3 cf3 L-21c ch3 cf3 L-21e ch3 cf3 L-22b ch3 cf3 L-22c ch3 cf3 L - 23b ch3 cf3 L-23c ch3 cf3 L-23i ch3 cf3 L-23g ch3 cf3 L-31a ch3 cf3 L-31b ch3 cf3 L-45c ch3 cf3 L-45d ch3 cf3 L-45e ch3 cf3 L-45f ch3 cf3 L-45g ch3 cf3 L-45m ch3 cf3 L-46c ch3 cf3 L-46d ch3 cf3 L - 46e 465 314918 200407073 Η C(CH3) 2ch2so2ch3 ch3 cf3 L-46f Η c(ch3)2ch2so2ch3 ch3 cf3 L-46g Η C(CH3)2CH2S02CH3 ch3 cf3 L-46j Η C(CH3) 2ch2so2ch3 ch3 cf3 L-46k Η c(ch3) 2ch2so2ch3 ch3 cf3 L-46r Η C(CH3) 2ch2so2ch3 ch3 cf3 L - 47a Η C(CH3)2CH2S02CH3 ch3 cf3 L-50b Η C(CH3)2CH2S02CH3 ch3 cf3 L - 50c Η C(CH3)2CH2S02CH3 ch3 cf3 L-51b Η C(CH3)2CH2S02CH3 ch3 cf2ci Ph-4-F Η c(ch3)2ch2so2ch3 ch3 cf2ci Ph-4-Cl Η c(ch3)2ch2so2ch3 ch3 cf2ci Ph-4-Br Η C(CH3)2CH2S02CH3 ch3 cf2ci Ph+CF3 Η C(CH3)2CH2S02CH3 ch3 cf2ci Ph-4-0CHF2 Η c(ch3)2ch2so2ch3 ch3 cf2ci Ph-4-0CF3 Η c(ch3)2ch2so2ch3 ch3 cf2ci Ph-3, 4-Cl2 Η C(CH3)2CH2S02CH3 ch3 CF2Br Ph-4-Cl Η C(CH3)2CH2S02CH3 ch3 cf2chf2 Ph-4-Cl Η c(ch3)2ch2so2ch3 ch3 cf2cf3 Ph-4-F Η C(CH3)2CH2S02CH3 ch3 cf2cf3 Ph+Cl Η c(ch3&gt;2ch2so2ch3 ch3 cf2cf3 Ph+Br Η c(ch3)2ch2so2ch3 ch3 cf2cf3 Pli - 4-CF3 Η C(CH3)2CH2S02CH3 ch3 cf2cf3 Ph-4-0CHF2 Η C(CH3) 2ch2so2ch3 ch3 cf2cf3 Ph-4-0CF3 Η c(ch3)2ch2so2ch3 ch3 cf2cf3 Ph-3, 4-Cl2 Η c(ch3)2ch2so2ch3 ch3 cf2cf2ci Ph-4-Cl Η C(CH3)2CH2S02CH3 ch3 cf2cf2cf3 Ph-4-C1 Η c(ch3)2ch2so2ch3 ch3 ch2och3 H Η c(ch3)2ch2so2ch3 ch3 CH20Et H Η C(CH3)2CH2S02CH3 ch3 ch2och2cf3 H Η C(CH3)2CH2S02CH3 ch3 ch2och2cf3 ch3 Η c(ch3)2ch2so2ch3 ch3 ch2och2cf3 Et Η C(CH3)2CH2S02CH3 ch3 ch2och2cf3 n-Pr Η c(ch3)2ch2so2ch3 ch3 ch2och2cf3 i - Pr Η c(ch3)2ch2so2ch3 ch3 ch2och2cf3 Ph-4-Cl Η c(ch3)2ch2so2ch3 ch3 ch2och2cf2cf3 H Η c(ch3)2ch2so2ch3 ch3 ch2och2cf2cf3 ch3
466 314918 200407073
Η C(CH3)2CH2S02CH3 ch3 ch2och2cf2cf3 Ph+Cl Η C(CH3)2CH2S02CH3 ch3 cf2ocf2cf2ocf3 H Η C(CH3) 2ch2so2ch3 ch3 CF (CF3)0CF2CF2CF3 H Η c(ch3)2ch2so2ch3 ch3 ch2sch3 H Η c(ch3)2ch2so2ch3 ch3 ch2so2ch3 H Η C(CH3)2CH2S02CH3 ch3 CH2SEt H Η C(CH3)2CH2S02CH3 ch3 ch2scf3 H Η C(CH3)2CH2S02CH3 ch3 ch2scf3 Ph-4-Cl Η C(CH3)2CH2S02CH3 ch3 ch2scf3 Ph-4-0CF Η c(ch3)2ch2so2ch3 ch3 CH2SPh H Η C(CH3)2CH2S02CH3 ch3 och3 H Η C(CH3)2CH2S02CH3 ch3 och3 Ph-4-Cl Η C(CH3)2CH2S02CH3 ch3 so2cf3 H Η c(ch3)2ch2so2ch3 ch3 SPh H Η c(ch3)2ch2so2ch3 ch3 T-22 H Η C(CH3)2CH2S02CH3 ch3 T-23 H Η C(CH3)2CH2S02CH3 ch3 T-24 H Η c(ch3&gt;2ch2so2ch3 ch3 Ph H Η C(CH3)2CH2S02CH3 ch3 Ph-4-F H Η C(CH3)2CH2S02CH3 ch3 Ph-4-Cl H Η C(CH3)2CH2S02CH3 ch3 Ph-4-Br H Η c(ch3)2ch2so2ch3 ch3 Ph-4-I H Η C(CH3) 2ch2so2ch3 ch3 Ph+CF3 H Η c(ch3)2ch2so2ch3 ch3 Ph~4-CH20CH2CF3 H Η c(ch3)2ch2so2ch3 ch3 Ph - 4-C(CF3)20H H Η C(CH3)2CH2S02CH3 ch3 Ph-4-0CHF2 H Η c(ch3)2ch2so2ch3 ch3 Ph-4-0CF3 H Η c(ch3)2ch2so2ch3 ch3 Ph-4-0CF2Br H Η C(CH3)2CH2S02CH3 ch3 Ph+0CH2CF3 H Η C(CH3)2CH2S02CH3 ch3 Ph-4-0CF2CHF2 H Η c(ch3)2ch2so2ch3 ch3 Ph-4-0CF2CHFCI H Η c(ch3)2ch2so2ch3 ch3 Ph~4-0CF2CHFBr H Η c(ch3) 2ch2so2ch3 ch3 Ph-4-0CF2CF2Br H Η c(ch3)2ch2so2ch3 ch3 Ph-4-0CF2CHFCF3 H Η C(CH3)2CH2S02CH3 ch3 Ph - 4-0CH(CF3)2 H Η c(ch3)2ch2so2ch3 ch3 Ph-4-0CF2CHF0CF3 H Η c(ch3)2ch2so2ch3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 H
467 314918 200407073
Η c(ch3)2ch2so2ch3 ch3 Ph-4-0S02CH3 H Η c(ch3)2ch2so2ch3 ch3 Ph-4-0S02CF3 H Η c(ch3)2ch2so2ch3 ch3 Ph-4-0 (Ph-4~CF3) H Η c(ch3)2ch2so2ch3 ch3 Ph-3-0 (L-45g) H Η G(CH3)2CH2S02CH3 ch3 Ph-4-〇 (L-45g) H Η C(CH3)2CH2S02CH3 ch3 Ph-4 - 0(L - 451) H Η C(CH3)2CH2S02CH3 ch3 Ph+SCH3 H Η c(ch3)2ch2so2ch3 ch3 Ph+S (0) CH3 H Η c(ch3&gt;2ch2so2ch3 ch3 Ph+S02CH3 H Η C(CH3)2CH2S02CH3 ch3 Ph+SCF3 H Η C(CH3)2CH2S02CH3 ch3 Ph - 4-S(0)CF3 H Η C(CH3) 2ch2so2ch3 ch3 Ph~4~S02CF3 H Η c(ch3)2ch2so2ch3 ch3 Ph-4-N02 H Η C(CH3)2CH2S02CH3 ch3 Ph-4-CN H Η c(ch3)2ch2so2ch3 ch3 Ph-4-C ⑼ NH2 H Η C(CH3)2CH2S02CH3 ch3 Ph-4-C ⑸ NH2 H Η C(CH3)2CH2S02CH3 ch3 Ph-3, 4-F2 H Η C(CH3)2CH2S02CH3 ch3 Ph-3-F_4-Cl H Η c(ch3)2ch2so2ch3 ch3 Ph-3, 4-Cl2 H Η c(ch3)2ch2so2ch3 ch3 Ph-3-F-4_CF 3 H Η C(CH3)2CH2S02CH3 ch3 Ph-3-F~4~0CHF 2 H Η c(ch3)2ch2so2ch3 ch3 Ph-3-C卜4-0CHF2 H Η C(CH3) 2ch2so2ch3 ch3 Ph-3-F-4-0CF3 H Η c(ch3)2ch2so2ch3 ch3 Ph+C 卜4-0CF3 H Η c(ch3)2ch2so2ch3 ch3 Ph-3~F-4-〇CF2Br H Η c(ch3)2ch2so2ch3 ch3 2-Naph H Η c(ch3)2ch2so2ch3 ch3 L~lb H Η c(ch3)2ch2so2ch3 ch3 L - lc H Η c(ch3)2ch2so2ch3 ch3 L-ld H Η c&lt;ch3)2ch2so2ch3 ch3 L-le H Η c(ch3)2ch2so2ch3 ch3 L- li H Η c(ch3)2ch2so2ch3 ch3 L~2b H Η c(ch3)2ch2so2ch3 ch3 L - 3c H Η c(ch3)2ch2so2ch3 ch3 L-3d H Η C(CH3)2CH2S02CH3 ch3 L-3e H Η C(CH3)2CH2S02CH3 ch3 L-3f H Η C(CH3)2CH2S02CH3 ch3 L-3k H
468 314918 200407073
Η C(CH3)2CH2S02CH3 ch3 L-31 H Η c(ch3)2ch2so2ch3 ch3 L-3o H Η c(ch3) 2ch2so2ch3 ch3 L - 4b H Η C(CH3) 2ch2so2ch3 ch3 L-4c H Η C(CH3)2CH2S02CH3 ch3 L - 6d H Η c(ch3)2ch2so2ch3 ch3 L - 6e H Η c(ch3)2ch2so2ch3 ch3 L_10b H Η c(ch3)2ch2so2ch3 ch3 L-lOc H Η c(ch3)2ch2so2ch3 ch3 L - 16a H Η c(ch3) 2ch2so2ch3 ch3 L - 16b H Η c(ch3)2ch2so2ch3 ch3 L- 17a H Η c(ch3)2ch2so2ch3 ch3 L - 21b H Η c(ch3)2ch2so2ch3 ch3 L-21c H Η C(CH3) 2ch2so2ch3 ch3 L - 21d H Η c(ch3)2ch2so2ch3 ch3 L - 21e H Η c(ch3)2ch2so2ch3 ch3 L-22b H Η c(ch3)2ch2so2ch3 ch3 L - 22c H Η c(ch3&gt;2ch2so2ch3 ch3 L~23b H Η c(ch3)2ch2so2ch3 ch3 L-23c H Η c(ch3)2ch2so2ch3 ch3 L-23f H Η c(ch3)2ch2so2ch3 ch3 L-23g H Η c(ch3)2ch2so2ch3 ch3 L~31a H Η c(ch3)2ch2so2ch3 ch3 L-31b H Η C(CH3)2CH2S02CH3 ch3 L - 45d H Η C(CH3)2CH2S02CH3 ch3 L - 45e H Η c(ch3)2ch2so2ch3 ch3 L-45J H Η C(CH3)2CH2S02CH3 ch3 L - 45g H Η c(ch3)2ch2so2ch3 ch3 L - 451 H Η c(ch3)2ch2so2ch3 ch3 L-45in H Η c(ch3)2ch2so2ch3 ch3 L-46d H Η c(ch3)2ch2so2ch3 ch3 L-46e H Η c(ch3)2ch2so2ch3 ch3 L - 46i H Η c(ch3)2ch2so2ch3 ch3 L-46g H Η c(ch3&gt;2ch2so2ch3 ch3 L - 46j H Η c(ch3)2ch2so2ch3 ch3 L - 46k H Η C(CH3)2CH2S02CH3 ch3 L - 46r H Η c(ch3)2ch2so2ch3 ch3 丄-47a H
469 314918 200407073
Η c(ch3)2ch2so2ch3 ch3 L-47e H Η c(ch3)2ch2so2ch3 ch3 L-50b H Η C(CH3)2CH2S02CH3 ch3 L-50c H Η c(ch3)2ch2so2ch3 ch3 L - 50d H Η C(CH3)2CH2S02CH3 ch3 L - 51b H Η C(CH3)2CH2S02CH3 Et cf3 Ph-4-Cl Η c(ch3)2ch2so2ch3 Et Ph-4-0CF3 H Η C(CH3)2CH2S02CH3 CH20H cf3 Ph-4-Cl Η c(ch3)2ch2so2ch3 ch2oh Ph-4-0CF3 H Η C(CH3)2CH2S02CH3 och3 cf3 Ph-4-Cl Η c(ch3)2ch2so2ch3 och3 Pb-4-0CF3 H Η C(CH3)2CH2S02CH3 sch3 cf3 Ph-4-C1 Η C(CH3)2CH2S02CH3 sch3 Ph-4-0CF3 H Η C(CH3)2CH2SEt ch3 cf3 Ph-4-F Η C(CH3)2CH2SEt ch3 cf3 Ph-4-Cl Η C(CH3)2CH2SEt ch3 cf3 Ph-4-Br Η C(CH3)2CH2SEt ch3 cf3 Ph-4-CF3 Η C(CH3) 2CH2SEt ch3 cf3 Ph-4-0CHF Η C(CH3)2CH2SEt ch3 cf3 Ph-4-OCF 3 Η C(CH3)2CH2SEt ch3 Ph-4~F H Η C(CH3) 2CH2SEt ch3 Ph-4-Cl H Η C(CH3)2CH2SEt ch3 Ph-4-Br H Η C(CH3)2CH2SEt ch3 Ph-4-CF 3 H Η C(CH3) 2CH2SEt ch3 Ph-4-0CHF2 H Η C(CH3) 2CH2SEt ch3 Ph-4-0CF3 H Η C(CH3)2CH2SEt ch3 Ph - 4-0 (L-45g) H Η C(CH3)2CH2S(0)Et ch3 cf3 Ph-4-F Η C(CH3) 2CH2S(0)Et ch3 cf3 Ph-4-Cl Η C(CH3)2CH2S(0)Et ch3 cf3 Ph-4-Br Η C(CH3)2CH2S(0)Et ch3 cf3 Ph+CF3 Η C(CH3)2CH2S(0)Et ch3 cf3 Ph-4-0CHF； Η C(CH3)2CH2S(0)Et ch3 cf3 Ph-4-0CF3 Η C(CH3)2CH2S(0)Et ch3 Ph-4-F H Η C(CH3)2CH2S(0)Et ch3 Ph-4-Cl H Η C(CH3)2CH2S(0)Et ch3 Ph-4-Br H Η C(CH3)2CH2S(0)Et ch3 Ph+CF3 H Η C(CH3)2CH2S(0)Et ch3 Ph-4-0CHF2 H
470 314918 200407073
Η C(CH3)2CH2S(0)Et ch3 Ph+0CF3 H Η C(CH3)2CH2S(0)Et ch3 Ph~4~0 (L~45g) H Η C(CH3)2CH2S02Et ch3 cf3 Ph-4-F Η C(CH3)2CH2S02Et ch3 cf3 Ph-4-Cl Η C(CH3) 2CH2S02Et ch3 cf3 PH - Br Η C(CH3) 2CH2S02Et ch3 cf3 Ph-4-CF3 Η C(CH3)2CH2S02Et ch3 cf3 Ph-4-0CHF Η C(CH3)2CH2S02Et ch3 cf3 Ph-4_0CF3 Η C(CH3)2CH2S02Et ch3 Ph+F H Η C(CH3)2CH2S02Et ch3 Ph+Cl H Η C(CH3)2CH2S02Et ch3 Ph+Br H Η C(CH3) 2CH2S02Et ch3 Ph+CF3 H Η C(CH3)2CH2S02Et ch3 Ph-4-0CHF2 H Η C(CH3)2CH2S02Et ch3 Ph-4-0CF3 H Η C(CH3)2CH2S02Et ch3 Ph-4-0 (L-45g) H Η C(CH3)2CH2SPr-n ch3 cf3 Ph-4-F Η C(CH3) 2CH2SPr-n ch3 cf3 Ph-4-Cl Η C(CH3) 2CH2SPr-n ch3 cf3 Ph~4-Br Η C(CH3)2CH2SPr - n ch3 cf3 Ph_4-CF 3 Η C(CH3)2CH2SPr-n ch3 cf3 Ph-4-0CHF Η C(CH3)2CH2SPr - n ch3 cf3 Ph-4-0CF3 Η C(CH3)2CH2SPr-n ch3 Ph-4-F H Η C(CH3)2CH2SPr-n ch3 Ph-4-Cl H Η C(CH3) 2CH2SPr-n ch3 Ph_4~Br H Η C(CH3)2CH2SPr-n ch3 Ph-4-CF3 H Η C(CH3) 2CH2SPr-n ch3 Ph-4-0CHF2 H Η C(CH3)2CH2SPr - n ch3 Ph-4-0CF3 H Η C(CH3) 2CH2SPr-n ch3 Ph-4-0 (L-45g) H Η C(CH3)2CH2S02Pr-n ch3 cf3 Ph-4-F Η C(CH3) 2CH2S02Pr-n ch3 cf3 PH-Cl Η C(CH3)2CH2S02Pr-n ch3 cf3 Ph-4-Br Η C(CH3)2CH2S02Pr - n ch3 cf3 Ph-4-CF3 Η C(CH3) 2CH2S02Pr-n ch3 cf3 Ph-4-OCHF: Η C(CH3)2CH2S02Pr-n ch3 cf3 Ph-4-0CF3 Η C(CH3)2CH2S02Pr-n ch3 Ph-4-F H Η C(CH3)2CH2S02Pr - n ch3 Ph+Cl H Η C(CH3)2CH2S02Pr - n ch3 Ph+Br H
47] 314918 200407073
Η C(CH3)2CH2S02Pr - η ch3 Ph-4-CF3 H Η C(CH3)2CH2S02Pr - η ch3 Ph-4-0CHF2 H Η C(CH3) 2CH2S02Pr-n ch3 Ph-4-0CF3 H Η C(CH3)2CH2S02Pr-n ch3 Ph-4 - 0.(L - 45g) H Η C(CH3)2CH2SPr-i ch3 cf3 Ph-4-F Η C(CH3)2CH2SPr-i ch3 cf3 Ph+Cl Η C(CH3&gt;2CH2SPr - i ch3 cf3 Ph-4-Br Η C(CH3)2CH2SPr-i ch3 cf3 Ph-4-CF3 Η C(CH3)2CH2SPr - i ch3 cf3 Ph-4-0CHF Η C(CH3)2CH2SPr-i ch3 cf3 Ph-4-0CF3 Η C(CH3)2CH2SPr-i ch3 Ph-4-F H Η C(CH3)2CH2SPr - i ch3 Ph-4-C1 H Η C(CH3)2CH2SPr-i ch3 Ph-4-Br H Η C(CH3)2CH2SPr-i ch3 Ph-4-CF3 H Η C(CH3)2CH2SPr-i ch3 Ph-4-0CHF2 H Η C(CH3&gt;2CH2SPr - i ch3 Ph-4-0CF3 H Η C(CH3)2CH2SPr-i ch3 Ph-4 -0(L - 45g&gt; H Η CH (CH3)CH2CH2SCH3 ch3 cf3 Ph-4-F Η CH (CH3)CH2CH2SCH3 ch3 cf3 Ph-4-Cl Η CH (CH3)CH2CH2SCH3 ch3 cf3 Ph-4-Br Η CH (CH3)CH2CH2SCH3 ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2CH2SCH3 ch3 cf3 Ph-4-0CHF Η CH (CH3)CH2CH2SCH3 ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2CH2SCH3 ch3 Pb~4~F H Η CH (CH3)CH2CH2SCH3 ch3 Ph-4-Cl H Η CH (CH3)CH2CH2SCH3 ch3 Ph+Br H Η CH (CH3)CH2CH2SCH3 ch3 Ph-4_CF3 H Η CH (CH3)CH2CH2SCH3 ch3 Ph-4-0CHF2 H Η CH (CH3)CH2CH2SCH3 ch3 Ph-4-0CF3 H Η CH (CH3)CH2CH2SCH3 ch3 Ph-4 - 0 (L - 45g) H Η CH (CH3)CH2CH2S(0) ch3 ch3 cf3 Ph-4-F Η CH(CH3)CH2CH2S(0)CH3 ch3 cf3 Ph-4-Cl Η CH(CH3)CH2CH2S(0)CH3 ch3 cf3 Ph+Br Η CH(CH3)CH2CH2S(0)CH3 ch3 cf3 Ph-4-CF3 Η ch(ch3kh2chw〇)ch3 ch3 cf3 Ph-4-OCHF Η CH(CH3)CH2CH2S(0)CH3 ch3 cf3 Ph-4-0CF3 Η CH(CH3)CH2CH2S(0)CH3 ch3 Ph+F H
472 314918 200407073
Η CH(CH3)CH2CH2S(0)CH3 ch3 Ph-4-Cl H Η CH(CH3)CH2CH2S(0)CH3 ch3 Ph+Br H Η CH (CH3)CH2CH2S(0) ch3 ch3 Ph+CF3 H Η CH(CH3)CH2CH2S(0)CH3 ch3 Ph-4-0CHF2 H Η CH (CH3)CH2CH2S(0) ch3 ch3 Ph-4-0CF3 H Η CH (CH3)CH2CH2S(0) ch3 ch3 Ph-4 - 0 (L-45g) H Η CH (CH3)CH2CH2S02CH3 ch3 cf3 Ph-4-F Η CH (CH3)CH2CH2S02CH3 ch3 cf3 PH-Cl Η CH (CH3)CH2CH2S02CH3 ch3 cf3 Ph-4-Br Η CH(CH3)CH2CH2S02CH3 ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2CH2S02CH3 ch3 cf3 Ph-4-OCHF Η CH (CH3)CH2CH2S02CH3 ch3 cf3 Ph-4_0CF3 Η CH (CH3)CH2CH2S02CH3 ch3 Ph-4-F H Η CH (CH3)CH2CH2S02CH3 ch3 PH-Cl H Η CH (CH3)CH2CH2S02CH3 ch3 Ph+Br H Η CH (CH3)CH2CH2S02CH3 ch3 Ph-4-CF3 H Η CH(CH3)CH2CH2S02CH3 ch3 Ph-4-0CHF2 H Η CH (CH3)CH2CH2S02CH3 ch3 Ph-4-0CF3 H Η CH (CH3)CH2CH2S02CH3 ch3 Ph-4-0 a~45g) H Η CH (CH3)CH2CH2SEt ch3 cf3 Ph-4-F Η CH (CH3)CH2CH2SEt ch3 cf3 Ph-4-C1 Η CH (CH3)CH2CH2SEt ch3 cf3 Ph+Br Η CH (CH3)CH2CH2SEt ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2CH2SEt ch3 cf3 Ph-4-OCHF: Η CH (CH3)CH2CH2SEt ch3 cf3 Ph-4-0CF3 Η CH(CH3)CH2CH2SEt ch3 Ph-4_F H Η CH (CH3)CH2CH2SEt ch3 Ph-4-Cl H Η CH(CH3)CH2CH2SEt ch3 Ph-4-Br H Η CH (CH3)CH2CH2SEt ch3 Ph-4-CF3 H Η CH (CH3)CH2CH2SEt ch3 Ph-4-0CHF2 H Η CH (CH3)CH2CH2SEt ch3 Ph-4_0CF3 H Η CH(CH3)CH2CH2SEt ch3 Ph-4-0(L-45g) H Η CH (CH3)CH2CH2S(0)Et ch3 cf3 Ph-4-Cl Η CH (CH3)CH2CH2S(0)Et ch3 Pli - 4-0CF3 H Η CH (CH3)CH2CH2S02Et ch3 cf3 Ph-4-Cl Η CH (CH3)CH2CH2S02Et ch3 Ph-4-0CF3 H Η CH(CH3) (CH2)3SCH3 ch3 cf3 Ph-4-F
473 314918 200407073
Η CH(CH3) (CH2)3SCH3 ch3 cf3 Ph-4-Cl Η CH(CH3) (CH2)3SCH3 ch3 cf3 Ph+Br Η CH(CH3) (CH2)3SCH3 ch3 cf3 Ph+CF3 Η CH(CH3) (CH2)3SCH3 ch3 cf3 Ph-4-0CHF Η CH(CH3) (CH2)3SCH3 ch3 cf3 Ph+0CF3 Η CH(CH3) (CH2)3SCH3 ch3 Ph-4-F H Η CH(CH3) (CH2)3SCH3 ch3 PH-C1 H Η CH(CH3) (CH2)3SCH3 ch3 Ph-4-Br H Η CH(CH3) (CH2)3SCH3 ch3 Ph-4-CF 3 H Η CH(CH3) (CH2)3SCH3 ch3 Ph-4-0CHF2 H Η CH(CH3) (CH2)3SCH3 ch3 Ph-4-0CF3 H Η CH(CH3) (CH2)3SCH3 ch3 Ph-4 - 0(L-45g) H Η CH(CH3) (CH2)3S(0)CH3 ch3 cf3 Ph-4-Cl Η CH(CH3) (CH2)3S(0)CH3 ch3 Ph-4-0CF3 H Η CH(CH3) (CH2)3S02CH3 ch3 cf3 Ph，4_F Η CH(CH3) (CH2)3S02CH3 ch3 cf3 Ph-4-Cl Η CH(CH3) (CH2)3S02CH3 ch3 cf3 Ph~4~Br Η CH(CH3) (CH2)3S02CH3 ch3 cf3 Ph-4-CF3 Η CH(CH3) (CH2)3S02CH3 ch3 cf3 Ph-4-0CHF Η CH(CH3) (CH2)3S02CH3 ch3 cf3 Ph-4-OCFa Η CH(CH3) (CH2)3S02CH3 ch3 Ph-4-F H Η CH(CH3) (CH2)3S02CH3 ch3 Ph+Cl H Η CH(CH3) (CH2)3S02CH3 ch3 Ph-4-Br H Η CH(CH3) (CH2)3S02CH3 ch3 Ph-4-CF 3 H Η CH(CH3) (CH2)3S02CH3 ch3 Ph-4-0CHF2 H Η CH(CH3) (CH2)3S02CH3 ch3 Ph-4-0CF3 H Η CH(CH3) (CH2)3S02CH3 ch3 Ph - 4-0 (L - 45g) H Η CH(CH3) (CH2)3SEt ch3 cf3 Ph-4-F Η CH(CH3) (CH2)3SEt ch3 cf3 Ph+Cl Η CH(CH3) (CH2)3SEt ch3 cf3 Ph~4~Br Η CH(CH3) (CH2)3SEt ch3 cf3 Ph-4_CF 3 Η CH(CH3) (CH2)3SEt ch3 cf3 Ph-4-OCHF: Η CH(CH3) (CH2) 3SEt ch3 · cf3 Ph-4-0CF3 Η CH(CH3) (CH2)3SEt ch3 Ph~4~F H Η CH(CH3) (CH2)3SEt ch3 Ph-4-Cl H Η CH(CH3) (CH2)3SEt ch3 Ph-4-Br H Η CH(CH3) (CH2) 3SEt ch3 Ph-4-CF3 H
474 314918 200407073 Η CH(CH3) (CH2)3SEt ch3 Ph-4-0CHF2 H Η CH(CH3) (CH2)3SEt ch3 Ph-4-0CF3 H Η CH(CH3) (CH2)3SEt ch3 Ph-4-0 a-45g) H Η CH(CH3) (CH2)3S(0)Et ch3 cf3 Ph+Cl Η CH(CH3) (CH2)3S(0)Et ch3 Ph-4-0CF3 H Η CH(CH3) (CH2)3S02Et ch3 cf3 Ph-4-C1 Η CH(CH3) (CH2)3S02Et ch3 Ph-4-0CF3 H Η C(CH3)2(CH2)3SCH3 ch3 cf3 Ph-4-F Η c(ch3)2(ch2&gt;3sch3 ch3 cf3 Ph-4-Cl Η c(ch3&gt;2(ch2)3sch3 ch3 cf3 Ph~4~Br Η c(ch3)2(ch2)3sch3 ch3 cf3 Ph-4-CF 3 Η c(ch3)2(ch2&gt;3sch3 ch3 cf3 Ph-4-0CHF Η c(ch3)2(ch2&gt;3sch3 ch3 cf3 Ph+0CF3 Η c(ch3)2(ch2&gt;3sch3 ch3 Ph~4~F H Η c(ch3)2(ch2)3sch3 ch3 Ph-4-Cl H Η c(ch3)2(ch2)3sch3 ch3 Ph+Br H Η c(ch3&gt;2(ch2)3sch3 ch3 Ph-4-CF3 H Η c(ch3&gt;2(ch2)3sch3 ch3 Ph-4-0CHF2 H Η c(ch3&gt;2(ch2&gt;3sch3 ch3 Ph-4-0CF3 H Η C(CH3)2(CH2)3SCH3 ch3 Ph-4-0(L-45g) H Η C(CH3&gt;2(CH2)3SEt ch3 cf3 Ph-4_F Η C(CH3)2(CH2)3SEt ch3 cf3 PH-Cl Η C(CH3)2(CH2)3SEt ch3 cf3 Ph-4-Br Η C(CH3)2(CH2)3SEt ch3 cf3 Ph~4-CF3 Η C(CH3)2(CH2)3SEt ch3 cf3 Ph-4-OCHF； Η C(CH3)2(CH2)3SEt ch3 cf3 Ph~4~0CF 3 Η C(CH3)2(CH2)3SEt ch3 Ph-4-F H Η C(CH3)2(CH2)3SEt ch3 Ph-4-Cl H Η C(CH3)2(CH2)3SEt ch3 Ph-4-Br H Η C(CH3)2(CH2)3SEt ch3 Ph 峭-CF3 H Η C(CH3)2(CH2)3SEt ch3 Ph-4-0CHF2 H Η C(CH3)2(CH2)3SEt ch3 Ph-4-0CF3 H Η C(CH3)2(CH2)3SEt ch3 Ph*4-0 (L-45g) H Η CH2NHC (0) OPr-i ch3 cf3 Ph+F Η CH2NHC(0) OPr-i ch3 cf3 Ph-4-Cl Η CH2NHC (0)0Pr~i ch3 cf3 Ph-4-Br Η CH〇NHC (O)OPr-i ch3 cf3 Ph-4-CF3
475 314918 200407073
Η CH2NHC (0) OPr-i ch3 cf3 Ph-4-0CHF2 Η CH2NHC (0) OPr-i ch3 cf3 Ph-4-0CF3 Η CH2NHC (0) OPr-i ch3 Ph-4-F H Η CH2NHC (0) OPr~i ch3 PH-Cl H Η CH2NHC (0) OPr-i ch3 Ph-4-Br H Η CH2NHC (0) OPr-i ch3 Ph-4-CF3 H Η CH2NHC (0) OPr-i ch3 Ph-4-0CHF2 H Η CH2NHC (0) OPr-i ch3 Ph-4-0CF3 H Η CH2NHC (0) OPr-i ch3 Ph - 4 一0 (L - 45g) H Η CH (CH3)CH2NHC (0) ch3 ch3 cf3 Ph-4-F Η CH (CH3)CH2NHC (0) ch3 ch3 cf3 Ph-4-Cl Η CH (CH3)CH2NHC (0) ch3 ch3 cf3 Ph-4，Br Η CH (CH3)CH2NHC (0)CH3 ch3 cf3 Ph-4-CF3 Η CH (CH3)CH2NHC (0) ch3 ch3 cf3 Ph~4-0CHF2 Η CH (CH3)CH2NHC (0)CH3 ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2NHC (0)CH3 ch3 Ph-4-F H Η CH (CH3)CH2NHC (0) ch3 ch3 Ph-4-Cl H Η CH(CH3)CH2NHC (0)CH3 ch3 Ph-4-Br H Η CH (CH3) CH2NHC (0) ch3 ch3 Ph-4-CF3 H Η CH (CH3)CH2NHC (0)CH3 ch3 Ph~4-0CHF2 H Η CH (CH3)CH2NHC (0)CH3 ch3 Ph-4-OCFa H Η CH (CH3)CH2NHC (0) ch3 ch3 Ph-4 - 0(L - 45g} H Η ch(ch3)ch2n(ch3)so2ch3 ch3 cf3 Ph-4-F Η ch(ch3)ch2n(ch3)so2ch3 ch3 cf3 Ph-4-Cl Η CH (CH3)CH2N(CH3)S02CH3 ch3 cf3 Ph-4-Br Η CH (CH3)CH2N(CH3)S02CH3 ch3 cf3 Ph-4-I Η ch(ch3)ch2n(ch3)so2ch3 ch3 cf3 Ph-4-CF3 Η ch(ch3)ch2n(ch3)so2ch3 ch3 cf3 Ph-4-0CHF2 Η CH (CH3)CH2N(CH3)S02CH3 ch3 cf3 Ph-4-0CF3 Η CH (CH3)CH2N(CH3)S02CH3 ch3 cf3 Ph-4-0CF2Br Η CH(CH3)CH2N(CH3)S02CH3 ch3 cf3 Ph-4-0CF2CHF2 Η CH (CH3)CH2N(CH3)S02CH3 ch3 cf3 Ph-4-0CF2CHFCF3 Η CH (CH3)CH2N(CH3)S02CH3 ch3 cf3 Ph-4-0CF2CHF0CF3 Η CH (CH3)CH2N(CH3)S02CH3 ch3 cf3 Ph-4~0CF2CHFCF2CF20CF3 Η CH (CH3)CH2N(CH3)S02CH3 ch3 cf3 Ph-4_SCF3 Η CH (CH3)CH2N(CH3)S02CH3 ch3 cf3 Ph-3, 4-F2 Η CH (CH3)CH2N(CH3)S02CH3 ch3 cf3 Ph-3**F-4-CI
476 314918 200407073
Η CH(CH3)CH2N(CH3)S02CH3 ch3 cf3 Ph-3, 4-C1 Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph-4-F H Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph+Cl H Η CH (CH3)CH2N{CH3)S02CH3 ch3 Ph-4-Br H Η CH(CH3)CH2N(CH3)S02CH3 ch3 Ph+CF3 H Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph-4-0CHF2 H Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph-4-0CF3 H Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph-4-0GF2Br H Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph-4-0CF2CHF2 H Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph-4-0CF2CHFCl H Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph-4-0CF2CHFCF3 H Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph-4-0CF2CHF0CF3 H Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 H Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph_4 - 0 (L-45g) H Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph+SCF3 H Η ch(ch3)ch2n(ch3)so2ch3 ch3 Ph-4-CN H Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph-3, 4-F2 H Η CH(CH3)CH2N(CH3)S02CH3 ch3 Ph - 3-F4-Cl H Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph-3, 4-Cl2 H Η ch(ch3)ch2n(ch3&gt;so2ch3. ch3 L - 45c H Η ch(ch3)ch2n(ch3)so2ch3 ch3 L - 45d H Η CH (CH3)CH2N(CH3)S02CH3 ch3 L~45e H Η CH (CH3)CH2N(CH3)S02CH3 ch3 L-45i H Η CH (CH3)CH2N(CH3)S02CH3 ch3 L - 45g H Η ch(ch3)ch2n(ch3)so2ch3 ch3 L - 451 H Η CH (CH3)CH2N(CH3)S02CH3 ch3 L - 45m H Η CH (CH3)CH2N(CH3)S02CH3 ch3 L-46c H Η ch(ch3)ch2n(ch3)so2ch3 ch3 L-46d H Η CH (CH3)CH2N(CH3)S02CH3 ch3 L~46e H Η CH (CH3)CH2N(CH3)S02CH3 ch3 L - 46i H Η CH(CH3)CH2N(CH3)S02CH3 ch3 L - 46g H Η CH(CH3)CH2N(CH3)S02CH3 ch3 L-46] H Η CH(CH3)CH2N(CH3)S02CH3 ch3 L-46k H Η ch(ch3)ch2n(ch3)so2ch3 ch3 L - 46r H Η CH (CH3)CH2N(CH3)S02CH3 ch3 L-47a H Η CH (CH3)CH2N(CH3)S02CH3 ch3 L-47e H Η C(CH3)2CH2NHC (0) och3 ch3 cf3 Ph-4-F
477 314918 200407073
Η C(CH3) 2CH2NHC (0) och3 ch3 cf3 Ph-4-Cl Η C(CH3)2CH2NHC (0) och3 ch3 cf3 Ph~4~Br Η C(CH3)2CH2NHC (0) och3 ch3 cf3 Ph-4-CF3 Η C(CH3)2CH2NHC (0) och3 ch3 cf3 Ph-4-0CHF2 Η G(CH3)2CH2NHC (0) och3 ch3 cf3 Ph-4-0CF3 Η C(CH3)2CH2NHC(0) och3 ch3 Ph+F H Η C(CH3)2CH2NHC (0) och3 ch3 Ph-4-Cl H Η C(CH3)2CH2NHC (0) och3 ch3 Ph-4-Br H Η C(CH3)2CH2NHC (0) och3 ch3 Ph+CF3 H Η C(CH3)2CH2NHC (0) och3 ch3 Ph-4-0CHF2 H Η C(CH3)2CH2NHC (0) och3 ch3 Ph-4-0CF3 H Η C(CH3)2CH2NHC (0) och3 ch3 Ph-4 - 0 (L - 45g) H Η ch(ch3)ch=noch3 ch3 cf3 Ph-4-F Η CH (CH3) CH=N0CH3 ch3 cf3 Ph+Cl Η CH (CH3)CH=N0CH3 ch3 cf3 Ph+Br Η CH (CH3) CH=N0CH3 ch3 cf3 Ph-4-1 Η CH(CH3)CH=N0CH3 ch3 cf3 Ph+CF3 Η CH (CH3)CH=N0CH3 gh3 cf3 Ph-4-0CHF2 Η CH (CH3) CH=N0CH3 ch3 cf3 Ph-4-0CF3 Η CH (CH3) CH=N0CH3 ch3 cf3 Ph-4~0CF2Br Η CH (CH3)CH=N0CH3 ch3 cf3 Ph-4-0CF2CHF2 Η . CH (CH3) CH=N0CH3 ch3 cf3 Ph-4-0CF2CHFCF Η CH (CH3)CH=N0CH3 ch3 cf3 Ph-4-0S02CH3 Η CH (CH3) CH=N0CH3 ch3 cf3 Ph-4-SCH3 Η CH (CH3) CH=N0CH3 ch3 cf3 Ph - 4-S (0) CH3 Η CH (CH3)CH=N0CH3 ch3 cf3 Ph+S02CH3 Η CH(CH3)CH=N0CH3 ch3 cf3 Ph+SCF3 Η CH (CH3) CH=N0CH3 ch3 cf3 Ph_4-SO2CF3 Η CH (CH3) CH=N0CH3 ch3 cf3 Ph-4~N02 Η CH (CH3) CH=N0CH3 ch3 cf3 Ph-4-CN Η CH (CH3)CH=N0CH3 ch3 cf3 Ph-3, 4-F2 Η CH (CH3)CH=N0CH3 ch3 cf3 Ph-3-F-4-C1 Η CH (CH3)CH=N0CH3 ch3 cf3 Ph-3, 4-Cl2 Η CH (CH3) CH=N0CH3 ch3 Ph-4-F H Η CH (CH3)CH=N0CH3 ch3 Ph-4-Cl H Η CH (CH3)CH=N0CH3 ch3 Ph-4-Br H Η CH (CH3)CH=N0CH3 ch3 Ph+CF3 H 参 478 314918 200407073 Η CH (CH3)CH=N0CH3 ch3 Ph-4-0CHF2 H Η CH (CH3)CH=N0CH3 ch3 Ph-4-0CF3 H Η CH (CH3)CH=N0CH3 ch3 Ph-4-0CF2Br H Η CH (CH3) CH=N0CH3 ch3 Ph-4-0CF2CHF2 H Η CH (CH3)CH=N0CH3 ch3 Ph-4-0CF2CHFCl H Η CH (CH3) CH=N0CH3 ch3 Ph-4-0CF2CHFCF3 H Η CH (CH3) CH=N0CH3 ch3 Ph-4-0CF2CHF0CF3 H Η CH (CH3)CH=N0CH3 ch3. Ph-4-0CF2CHF0CF2CF2CF3 H Η CH (CH3) CH=N0CH3 ch3 Ph - 4-0 (L - 45g} H Η CH (CH3)CH=N0CH3 ch3 Ph-4-SCFa H Η CH (CH3)CH=N0CH3 ch3 Ph-4-CN H Η CH (CH3)CH=N0CH3 ch3 Ph-3, 4-F2 H Η CH (CH3) CH=N0CH3 ch3 Ph-3-F-4_C1 H Η CH (GH3) CH=N0CH3 ch3 Ph-3,4-Cl2 H Η CH (CH3)CH=N0CH3 ch3 L-45c H Η CH(CH3)CH=N0CH3 ch3 L-45d H Η CH(CH3)CH=NOCH3 ch3 L-45e H Η CH (CH3)CH=N0CH3 ch3 L-45f H Η CH(CH3)CH=N0CH3 ch3 L - 45g H Η CH (CH3)CH=N0CH3 ch3 L-451 H Η CH (CH3)CH=N0CH3 ch3 L-45m H Η CH (CH3)CH=N0CH3 ch3 L-46c H Η CH (CH3) CH=N0CH3 ch3 L-46d H Η ch(ch3)ch=noch3 ch3 L-46e H Η ch(ch3)c_ch3 ch3 L - 46i H Η CH(CH3)CH=NOCH3 ch3 L-46g H Η CH (CH3)CH=N0CH3 ch3 L - 46j H Η CH (CH3)CH=N0CH3 ch3 L - 46k H Η CH (CH3)CH=N0CH3 ch3 L-46r H Η CH(CH3)CH=NOCH3 ch3 L-47a H Η CH(CH3)CH=NOCH3 ch3 L-47e H Η CH(CH3)CH=N0Pr-n ch3 cf3 Ph-4-F Η CH(CH3)CH=NOPr - n ch3 cf3 Ph-4-Cl Η CH (CH3)CH=NOPr-n ch3 cf3 Ph-4-Br Η CH (CH3)CH=NOPr-n ch3 cf3 Ph-4二CF3 Η CH (CH3)CH=N0Pr-n ch3 cf3 Ph-4-0CHF Η CH(CH3)CH=NOPr - n ch3 cf3 Ph+0CF3
479 314918 200407073 Η CH (CH3) C_Pr - η ch3 cf3 Ph+0S02CH Η CH(CH3)CH=NOPr-η ch3 cf3 Ph+SCH3 Η CH (CH3)CH-NOPr-n ch3 cf3 Ph-4-S (0) CH： Η CH (CH3)CH=N0Pr-n ch3 cf3 Ph-4-S02CH3 Η CH (CH3) CH=N0Pr-n ch3 cf3 Ph-4-CN Η CH (CH3) CH=N0Pr-n ch3 cf3 Ph-3,4-Cl2 Η CH(CH3)CH=N0Pr - n ch3 cf3 L-46d Η CH (CH3) CH=N0Pr-n ch3 Ph-4-F H Η CH (CH3)CH=N0Pr-n ch3 Ph+Cl H Η CH (CH3)CH=N0Pr~n ch3 Ph~4-Br H Η CH (CH3)CH=NOPr-n ch3 Ph-4-CF3 H Η CH(CH3)CH=N0Pr - n ch3 Ph-4-0CHF2 H Η CH(CH3)CH=N0Pr-n ch3 Ph-4-0CF3 H Η CH (CH3)CH=N0Pr-n ch3 Ph-4-0 (L-45g) H Η CH(CH3)CH=N0Pr-n ch3 Ph-4-SCF3 H Η CH (CH3)CH=NOPr-n ch3 Ph-4-CN H Η CH (CH3) CH=N0Pr - n ch3 Ph-3, 4-Cl2 H Η C (CH3) 2ch=noh ch3 cf3 Ph-4-F Η C (CH3) 2ch=noh ch3 cf3 Ph-4-Cl Η C (CH3) 2ch=noh ch3 cf3 Ph-4-Br Η C (CH3) 2ch=noh ch3 cf3 Ph-4-CF3 Η c (CH3) 2ch=noh ch3 cf3 Ph-4-0CHF2 Η c (ch3) 2ch=noh ch3 cf3 Ph-4-0CF3 Η c (ch3) 2ch=noh ch3 Ph-4-F H Η C (CH3) 2ch=noh ch3 Pti-4-Cl H Η C (CH3) 2ch=noh ch3 Ph-4-Br H Η c (ch3) 2ch=noh ch3 PH - CF3 H Η C (CH3) 2ch=noh ch3 Ph-4-0CHF2 H Η c (ch3) 2ch=noh ch3 Ph-4-0CF3 H Η C (CH3) 2ch=noh ch3 Ph~4~0 (L-45g) H Η C (CH3) 2ch=noch3 ch3 cf3 Ph-4-F Η c (ch3) 2ch=noch3 ch3 cf3 Ph-4-Cl Η C (CH3) 2ch=noch3 ch3 cf3 Ph-4-Br Η c(ch3)2ch=noch3 ch3 cf3 Ph-4-I Η C(CH3)2CH=NOCH3 ch3 cf3 Ph+CF3 Η C(CH3) 2ch=noch3 ch3 cf3 Ph-4-0CHF2 Η c(ch3)2ch=noch3 ch3 cf3 P1HI-0CF3
480 314918 200407073 Η C(CH3)2CH=NOCH3 ch3 cf3 Ph-4-0CF2Br Η C(CH3) 2ch=noch3 ch3 cf3 Ph-4-0CF2CHF2 Η c(ch3)2ch=noch3 ch3 cf3 Ph-4-0CF2CHFCF3 Η C(CH3) 2ch=noch3 ch3 cf3 Ph-4-0S02CH3 Η C(CH3)2CH=NOCH3 ch3 cf3 Ph-4-SCH3 Η c(ch3)2ch=noch3 ch3 cf3 Ph-4-S (0) CH3 Η C(CH3) 2ch=noch3 ch3 cf3 Ph-4_S02CH3 Η C(CH3) 2WOCH3 ch3 cf3 Ph-4-SCF3 Η C (CH3) 2ch=noch3 ch3 cf3 Ph-4-S02CF3 Η C(CH3) 2ch=noch3 ch3 cf3 Ph-4-N02 Η c(ch3) 2ch=noch3 ch3 cf3 Ph-4-CN Η C(CH3) 2ch=noch3 ch3 cf3 Ph-3, 4-F2 Η C(CH3)2CH=NOCH3 ch3 cf3 Ph-3-F_4_Cl Η C(CH3) 2ch=noch3 ch3 cf3 Ph-3,4-Cl2 Η c(ch3) 2ch=noch3 ch3 Ph-4-F H Η C(CH3)2CH=NOCH3 ch3 Ph-4-Cl H Η C(CH3)2CH=NOCH3 ch3 Ph_4-Br H Η c(ch3)2ch=noch3 ch3 Ph-4-CF3 H Η C (CH3) 2ch=noch3 ch3 Ph-4-0CHF2 H Η C(CH3)2CH=NOCH3 ch3 Ph-4-0CF3 H Η C(CH3)2CH=NOCH3 ch3 Ph-4-0CF2Br H Η C(CH3) 2ch=noch3 ch3 Ph-4~0CF2CHF2 H Η C(CH3)2CH=NOCH3 ch3 Ph-4-0CF2CHFCl H Η C(CH3)2CH=N0CH3 ch3 Ph-4-0CF2CHFCF3 H Η C(CH3) 2ch=noch3 ch3 Ph-4-0CF2CHF0CF3 H Η C(CH3) 2ch=noch3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 H Η c(ch3) 2ch=noch3 ch3 Ph - 4-0 (L - 45g) H Η C(CH3) 2ch=noch3 ch3 Ph-4-SCF3 H Η C(CH3) 2ch=noch3 ch3 PH - CN H Η C (CH3) 2ch=noch3 ch3 Ph-3, 4-F2 H Η C(CH3)2CH=N0CH3 ch3 Ph-3-F-4-Cl H Η C(CH3) 2ch=noch3 ch3 Ph-3, 4-Cl2 H Η C(CH3) 2ch=noch3 ch3 L_45c H Η C(CH3) 2ch=noch3 ch3 L-45d H Η C(CH3) 2ch=noch3 ch3 L - 45e H Η C(CH3) 2ch=noch3 ch3 L - 45i H Η C(CH3) 2ch=noch3 ch3 L-45g H 481 314918
200407073
Η C{CH3)2CH=N0CH3 ch3 L-451 H Η C(CH3)2CH=N0CH3 ch3 L_45m H Η C (CH3) 2ch=noch3 ch3 L - 46c H Η C(CH3)2CH=N0CH3 ch3 L-46d H Η C (CH3) 2ch=noch3 ch3 L-46e H Η C(CH3)2CH=N0CH3 ch3 L-46f H Η C(CH3)2CH=N0CH3 ch3 L - 46g H Η C(CH3)2CH=N0CH3 ch3 L - 46j H Η C(CH3)2CH=N0CH3 ch3 L - 46k H Η C(CH3)2CH=N0CH3 ch3 L - 46r H Η C (CH3) 2ch=noch3 ch3 L-47a H Η c (ch3) 2ch=noch3 ch3 L-47e H CH2CH=CH2CH2CH=CH2 ch3 cf3 Ph-4-Cl ch2 &gt;ch=ch2ch2ch=ch2 ch3 Ph~4-0CF3 H Η c(ch3)2ch=ch2 ch3 cf3 Ph-4-F Η C(CH3)2CH=CH2 ch3 cf3 PH，C1 Η c(ch3)2ch=ch2 ch3 cf3 Ph-4-Br Η c(ch3)2ch=ch2 ch3 cf3 Ph-4-CF3 Η c(ch3)2ch=ch2 ch3 cf3 Ph-4-0CHF2 Η C(CH3)2CH=CH2 ch3 cf3 Ph-4-0CF3 Η C(CH3)2CH=CH2 ch3 cf3 Ph-4-0S02CH Η C(CH3)2CH=CH2 ch3 cf3 Ph+SCH3 Η C(CH3)2CH=CH2 ch3 cf3 Ph-4-S (0) CH： Η c(ch3)2ch=ch2 ch3 cf3 Ph-4-S02CH3 Η C(CH3)2CH=CH2 ch3 cf3 Ph+CN Η C(CH3)2CH=CH2 ch3 cf3 L-46d Η c(ch3)2ch=ch2 ch3 Ph-4-F H Η C(CH3)2CH=CH2 ch3 Ph-4-Cl H Η c(ch3)2ch=ch2 ch3 Ph-4-Br H Η C(CH3)2CH=CH2 ch3 Ph-4-CF3 H Η c(ch3)2ch=ch2 ch3 Ph+0CHF2 H Η C(CH3)2CH=CH2 ch3 Ph-4-0CF3 H Η C(CH3)2CH=CH2 ch3 Ph-4-0S02CH3 H Η c(ch3)2ch=ch2 ch3 Ph - 4-0 (L - 45g) H Η c(ch3)2ch=ch2 ch3 Pb-4-SCH3 H Η c(ch3)2ch=ch2 ch3 Ph+S (0) CH3 H Η C(CH3)2CH=CH2 ch3 Ph-4-S02CH3 H
482 314918 200407073 Η C(CH3)2CH=CH2 ch3 Ph-4-CN H CH3CH2CeCH ch3 cf3 Ph-4-Cl CH, ,ch2c=ch ch3 cf3 Ph-4-S02CH3 CH: ,CH2CeCH ch3 Ph~4-0CF3 H CH： ,ch2c=ch ch3 Ph-4-0 (L-45g&gt; H H C(CH3)2C=CH ch3 cf3 Ph~4~F H C(CH3) 2CeCH ch3 cf3 Ph-4-Cl H C(CH3)2feGH ch3 cf3 Ph~4-0CHF2 H C(CH3) 2CeCH ch3 cf3 Ph-4-0S02CH3 H C(CH3)2C=CH ch3 cf3 Ph~4~SCH3 H C(CH3)2teCH ch3 cf3 Ph-4-S (0)CH3 H C(CH3) 2CeCH ch3 cf3 Ph-4-S02CH3 H C(CH3)2feCH ch3 cf3 Ph-4-SEt H C(CH3)2CeCH ch3 cf3 Ph-4-S (0)Et H C(CH3)2feCH ch3 cf3 Ph-4-S〇2Et H C(CH3)2C=CH ch3 cf3 Ph-4-SPr-n H C(CH3)2feCH ch3 cf3 Ph-4-S(0)Pr-n H C(CH3)2feCH ch3 cf3 Ph-4-S02Pr-n H C(CH3) 2CeCH ch3 cf3 Ph-4~SPr~i H C(CH3) 2ChCH ch3 cf3 Ph-4-S (O)Pr-i H C(CH3)2feCH ch3 cf3 Ph-4-S02Pr-i H C(CH3) 2feCH ch3 cf3 Ph-4-SCHF2 H C&lt;CH3) 2CeCH ch3 cf3 Ph-4-S (0)CHF2 H C(CH3) 2teCH ch3 cf3 Ph-4-S02CHF2 H C(CH3)2feCH ch3 cf3 Ph-4-SCF3 H C(CH3)2teCH ch3 cf3 Ph-4-S (0) CF3 H C(CH3) 2c=ch ch3 cf3 Ph-4-S02CF3 H C(CH3) 2CsCH ch3 cf3 Ph-4-SCF2Cl H C(CH3)2feCH ch3 cf3 Ph-4-S (0) CF2C1 H C(CH3) 2CsCH ch3 cf3 Ph+S02CF2C1 H C(CH3)2feCH ch3 cf3 Ph-4-SCF2Br H C(CH3) 2feCH ch3 cf3 Ph-4-S (0) CF2Br H C(CH3) 2CsCH ch3 cf3 Ph-4-S02CF2Br H C(CH3)2feCH ch3 cf3 Ph-4-CN H C(CH3) 2CeCH ch3 cf3 Ph-4-C (0) NH2 H C(CH3) 2CeCH ch3 cf3 Ph-4-C ⑸ NH2 H C(CH3)2feCH ch3 cf3 Ph-3, 4-F2 483 314918 200407073
Η C(CH3)2C=CH ch3 cf3 Ph-3-F-4-Cl Η C(CH3)2CeCH ch3 cf3 Ph-3, 4~C12 Η C(CH3)2feCH ch3 cf3 卜45c Η C(CH3)2feCH ch3 cf3 L - 45d Η C(CH3)2CeCH ch3 cf3 L-45e Η C(CH3)2feCH ch3 cf3 L - 45g Η C(CH3)2teCH ch3 cf3 L~45in Η C(CH3)2C=CH ch3 cf3 L&quot;46c Η C(CH3)2M ch3 cf3 L-46d Η C (CH3) 2c=ch ch3 cf3 L-46e Η C(CH3)2C=CH ch3 cf3 L - 46g Η c(ch3)2_ ch3 cf3 L-46j Η C(CH3)2CsCH ch3 cf3 L-46k Η C(CH3)2CsCH ch3 cf3 L~46q Η C(CH3) 2CeCH ch3 cf3 L - 46r Η c (ch3) 2_ ch3 cf3 L - 47a Η C(CH3)2teCH ch3 cf3 L-47e Η C (CH3) 2feCH ch3 ΡΗ-F H Η C(CH3)2C=CH ch3 Ph-4-Cl H Η C(CH3)2C=CH ch3 Ph-4~Br H Η C(CH3)2C=CH ch3 Ph+CF3 H Η C(CH3)2C=CH ch3 Ph-4-0CHF2 H Η C(CH3) 2ChCH ch3 Ph-4-0CF3 H Η C(CH3)2feCH ch3 Ph-4-SCF3 H Η C(CH3)2feCH ch3 Ph-4-N02 H Η C(CH3)2C=CH ch3 Ph-4-CN H Η C(CH3)2feCH ch3 Ph-4-C (0) NH2 H Η C(CH3)2feCH ch3 Ph-4-C ⑸ NH2 H Η C(CH3)2feCH ch3 Ph-3, 4-F2 H Η C(CH3) 2feCH ch3 Ph-3-F-4-C1 H Η C(CH3)2C=CH ch3 Ph-3, 4-C12 H Η C(CH3)2feCH ch3 L-45c H Η C(CH3)2M ch3 L-45d H Η C(CH3&gt; 2feCH ch3 L-45e H Η C(CH3)2C=CH ch3 L - 45g H Η C(CH3)2C=CH ch3 L-451 H Η C(CH3)2CeCH ch3 H
484 314918 200407073 Η C(CH3) 2feCH ch3 L - 46c H Η C(CH3)2C=CH ch3 L - 46d H Η C(CH3)2C=CH ch3 L - 46e H Η C(CH3)2C=CH ch3 L_46g H Η C(CH3&gt; 2c=ch ch3 L-46j H Η C(CH3&gt;2CeCH ch3 L - 46k H Η C(CH3)2CeCH ch3 L - 46q H Η C(CH3&gt; 2C三CH ch3 L - 46r H Η C(CH3)2feCH ch3 L - 47a H Η c(ch3&gt;2m ch3 L - 47e H Η i-Pr ch3 Ph - 4 一0 (L-45c) H Η i-Pr ch3 Ph - 4-0 (L - 45d&gt; H Η i-Pr ch3 Ph-4-0 (L-45e) H Η i-Pr ch3 Ph-4-0(L - 45g&gt; H Η i-Pr ch3 Ph - 4-0 (L-48b) H Η s - Bu ch3 Ph-4-0 (L-45c) H Η s-Bu ch3 Ph-4-0 (L-45d) H Η s-Bu ch3 Ph-4-0(L-45e) H Η s-Bu ch3 Ph - 4-0 (L - 48b) H Η CH(CH3)CH20CH3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 H Η CH (CH3)CH20CH3 ch3 Ph - 4-0 (L-45e) H Η CH (CH3)CH20CH3 ch3 Ph-4-0 (L-451) H Η CH (CH3)CH20CH3 ch3 Ph - 4_0 (L - 48b&gt; H Η CH (CH3)CH20C (0) ch3 ch3 Ph - 4-0 (L-45e) H Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-0 (L-451) H Η CH (CH3)CH20C (0) ch3 ch3 Ph-4-0 (L-48b) H Η CH (CH3)CH20C (0)NHCH3 ch3 Ph - 4-0 (L - 45e) H Η CH (CH3)CH20C (0) nhch3 ch3 Ph-4-0 (L-451) H Η CH (CH3)CH20C (0) nhch3 ch3 Ph-4-0 a-48b) H Η CH (CH3)CH20C (O)NHEt ch3 Ph-4-0 (L-45d) H Η CH (CH3)CH2OC (O)NHEt ch3 Ph-4 - 0 (L - 45e) H Η CH (CH3)CH2OC (O)NHEt ch3 Ph - 4-0 (L-451) H Η CH (CH3)CH2OC (0) NHEt ch3 Ph-4-0 (L-48b) H Η CH(CH3}CH2OP ⑸（OCH3) 2 ch3 Ph - 4 一0 (L - 45e) H Η CH(CH3)CH2OP(S) (OCH3) 2 ch3 Ph-4-0 (L-451) H Η CH(CH3)CH2OP(S) (〇ch3)2 ch3 Ph - 4-0(L-48b&gt; H Η CH(CH3)CH2OP(S) (OEt)2 ch3 Ph - 4-0(L - 45e&gt; H 485 314918
200407073
Η CH(CH3)CH2OP(S) (0Et)2 ch3 Ph-4 - 0(L - 451) H Η ch(ch3)ch2op ⑸（0Et&gt;2 ch3 Ph-4-0 (L-48b) H Η C(CH3)2CH20CH3 ch3 Ph-4~0CF2CHF0CF2CF2CF3 H Η C(CH3)2CH20CH3 ch3 Ph-4-0 (L-45e) H Η C(CH3)2CH20CH3 ch3 Ph-4-0 (L-451) H Η C(CH3) 2ch2och3 ch3 Ph-4-0 (L - 48W H Η c(ch3)2ch2oc(o)nhch3 ch3 Ph-4-0 (L-45e) H Η C(CH3)2CH20C (0) nhch3 ch3 Ph-4-0 (L - 451) H Η C(CH3) 2CH20C (0) nhch3 ch3 Ph-4-0 (L-48b) H Η C(CH3)2CH20C (O)NHEt ch3 Ph-4-0 (L - 45d) H Η C(CH3)2CH2OC (O)NHEt ch3 Ph-4 - 0(L - 451) H Η C(CH3)2CH2OC (0) NHEt ch3 Ph-4-0 (L-48b) H Η CH (CH3)CH2CH2OEt ch3 Ph-4-0 (L-45e&gt; H Η CH (CH3)CH2CH2OEt ch3 Ph-4 - 0(L-451) H Η CH (CH3)CH2CH2OEt ch3 Ph-4-0 (L-48b) H Η CH (CH3)CH2SCH3 ch3 CN Ph-4-F Η CH (CH3)CH2SCH3 ch3 CN Ph-4-Cl Η CH (CH3)CH2SCH3 gh3 CN Ph+Br Η CH(CH3)CH2SCH3 ch3 CN Ph+CF3 Η CH(CH3)CH2SCH3 ch3 CN Ph-4-0CHF2 Η CH (CH3)CH2SCH3 ch3 CN Ph+OCF3 Η CH (CH3)CH2SCH3 ch3 CN Ph-3, 4~C12 Η CH (CH3)CH2SCH3 ch3 Ph-4 - 0 (Ph+F&gt; H Η CH (CH3)CH2SCH3 ch3 Ph-4-0 (Ph~4~CI) H Η CH (CH3)CH2SCH3 ch3 Ph-4**0 (Ph-4-Br) H Η CH (CH3)CH2SCH3 ch3 PH-0 (P1H-0CF3) H Η CH (CH3)CH2SCH3 ch3 Ph-4-0(L-21b) H Η CH (CH3)CH2SCH3 ch3 Ph - 4-0(L-21c) H Η CH (CH3)CH2SCH3 ch3 Ph-4-0 (L-21d) H Η ch&lt;ch3)ch2sch3 ch3 Ph-4-0(L&gt;21e) H Η CH(CH3)CH2SCH3 ch3 Ph - 4-0(L - 45c&gt; H Η CH (CH3)CH2SCH3 ch3 Ph-3 - 0 (L - 45d) H Η CH(CH3)CH2SCH3 ch3 Ph-4-0 a~45d) H Η CH (CH3)CH2SCH3 ch3 Ph - 3-0 (L-45e) H Η CH (CH3)CH2SCH3 ch3 Ph - 4 一0(L-45e) H Η CH (CH3)CH2SCH3 ch3 Ph-4-0 (L-45f) H Η CH (CH3)CH2SCH3 ch3 Ph-4 - 0(L - 48b) H
486 314918 200407073
Η CH(CH3)CH2S(0) ch3 ch3 CN Ph-4-F Η CH (CH3)CH2S(0) CH3 ch3 CN Ph+Cl Η CH (CH3)CH2S(0) CH3 ch3 CN Ph-4-Br Η CH (CH3)CH2S(0) CH3 ch3 CN Ph-4-CF3 Η CH(CH3)CH2S(0) ch3 ch3 CN Ph-4-0CHF2 Η CH (CH3)CH2S(0) CH3 ch3 CN Ph-4-0CF3 Η CH(CH3)CH2S(0) ch3 ch3 CN Ph-3, 4-Cl2 Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0 (Ph-4-F) H Η CH (CH3)CH2S(0) CH3 ch3 Ph - 4-0 (Ph-4-Cl) H Η CH (CH3)CH2S(0) CH3 ch3 Ph - 4-0 (Ph-4-Br) H Η CH(CH3)CH2S(0) ch3 ch3 Ph-4-0(L-21b) H Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0(L-21c) H Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0 (L-21d) H Η CH (CH3)CH2S(0)CH3 ch3 Ph-4-0 (L-21e) H Η CH (CH3)CH2S(0) CH3 ch3 Ph-4-0 (L-45c) H Η ch3 Ph-4-0 (L-45d) H Η CH (CH3) CH2S(0)CH3 ch3 Ph+O (L - 45e&gt; H Η CH(CH3)CH2S(0) ch3 ch3 Ph-4 -0 (L-45f) H Η CH (CH3)CH2S(0) CH3 ch3 Ph+O (L_451) H Η CH (CH3)CH2S(0)CH3 ch3 Ph-4-0 (L-48b) H Η CH (CH3)CH2S02CH3 ch3 CN Ph+F Η CH (CH3)CH2S02CH3 ch3 CN Ph-4-Cl Η CH (CH3)CH2S02CH3 ch3 CN Ph-4-Br Η CH (CH3)CH2S02CH3 ch3 CN Ph-4-CF3 Η CH (CH3)CH2S02CH3 ch3 CN Ph-4-0CHF2 Η CH(CH3)CH2S02CH3 ch3 CN Ph-4-0CF3 Η CH (CH3)CH2S02CH3 ch3 CN Ph-3,4-Cl2 Η ch(ch3)ch2so2ch3 ch3 Ph - 4-0 (Ph - 4 一F) H Η CH (CH3)CH2S02CH3 ch3 Ph-4-0 (Ph-4-Cl) H Η CH (CH3)CH2S02CH3 ch3 Ph-4-0 (Ph-4-Br) H Η CH (CH3)CH2S02CH3 ch3 Ph-4-0 (L-21b) H Η CH(CH3)CH2S02CH3 ch3 Ph-4-0 (L-21c) H Η CH(CH3)CH2S02CH3 ch3 Ph-4-0 (L-21d) H Η ch(ch3)ch2so2ch3 ch3 Ph - 4-0(L-21e) H Η CH (CH3)CH2S02CH3 ch3 Ph-4 - 0 (L - 45c) H Η CH(CH3)CH2S02CH3 ch3 Ph-4-0 (L - 45d) H Η CH (CH3)CH2S02CH3 ch3 Ph-3-0 (L-45e) H
487 314918 200407073 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H CH (CH3)CH2S02CH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3) 2CH2SCH3 H C(CH3)2CH2SCH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3) 2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0)CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3 H C(CH3)2CH2S(0) CH3
ch3 Ph-4-0 (L-45e) ch3 Ph - 4-0 (L-45f) ch3 Ph - 4-0 (L - 48b) ch3 CN ch3 CN ch3 CN ch3 CN ch3 CN ch3 CN ch3 CN ch3 Ph - 4 -0 (Ph - 4-F) ch3 Ph-4-0 (Ph-4-Cl) ch3 Ph-4-0 (Ph-4-Br) ch3 Ph-4-0 (Ph-4-0CF3) ch3 Ph-4-0 (L-21b) ch3 Ph - 4 -0(L-21c) ch3 Ph - 4-0(L-21d) ch3 Ph-4-0 (L-21e) ch3 Ph - 4-0 (L - 45c) ch3 Ph-3-0 (L-45d) ch3 Ph-4-0 (L-45d) ch3 Ph-3 - 0(L-45e) ch3 Ph-4 - 0 (L - 45e) ch3 Ph-4-0(L - 45i&gt; ch3 Ph-4 - 0 (L-48b) ch3 CN ch3 CN ch3 CN ch3 CN ch3 CN ch3 CN ch3 CN ch3 Ph-4~0 (Ph~4~F) ch3 Ph-4-0(Ph-4-Cl) ch3 Ph-4-0(Ph-4 - Br) ch3 Ph-4-0 (L-21b) ch3 Ph+0(L - 21c) H H
H H H Ph-4-F Ph-4-CI Ph-4-Br Ph-4-CF3 Ph-4-0CHF2 Ph-4-OCFa Ph-3, 4-Cl2 H
Pb-4~F Ph-4-C! Ph~4-Br Ph+CF3 Ph-4-0CHF2 Ph~4*OCF 3 Ph-3, 4~C12 488 314918 200407073
Η C(CH3) 2CH2S(0) ch3 ch3 Ph-4-0 (L-21d) H Η C(CH3)2CH2S(0) ch3 ch3 Ph-4一 0(L-21e) H Η C(CH3)2CH2S(0) ch3 ch3 Ph - 4 一0 (L-45c) H Η C(CH3) 2CH2S(0) ch3 ch3 Ph-4 一0 (L-45d) H Η c(ch3)2ch2s_3 ch3 Ph-4-0 (L-45e) H Η C(CH3) 2CH2S(0) ch3 ch3 Ph-4-0 (L-45f) H Η c(ch3)2ch2s(o)ch3 ch3 Ph - 4-0(L - 451) H Η C(CH3) 2CH2S(0) ch3 ch3 Ph-4 - 0 (L - 48b) H Η c(ch3) 2ch2so2ch3 ch3 CN Ph-4-F Η C(CH3) 2ch2so2ch3 ch3 CN Ph+Cl Η C(CH3) 2ch2so2ch3 ch3 CN Ph-4-Br Η C(CH3) 2ch2so2ch3 ch3 CN Ph-4-CF3 Η C(CH3) 2ch2so2ch3 ch3 CN Ph-4-OCHF Η C(CH3) 2ch2so2ch3 ch3 CN Ph-4-0CF3 Η C(CH3) 2ch2so2ch3 ch3 CN Ph-3, 4-Cl Η C(CH3) 2ch2so2ch3 ch3 Ph-4-0 (Ph-4-F) H Η C(CH3) 2ch2so2ch3 ch3 Ph-4-0 (Ph-4 - Cl) H Η c(ch3&gt;2ch2so2ch3 ch3 Ph-4~0 (Ph-4-Br) H Η C(CH3) 2ch2so2ch3 ch3 Ph-4 - 0(L-21b) H Η C(CH3)2CH2S02CH3 ch3 Ph-4-0 (L-21c) H Η c(ch3) 2ch2so2ch3 ch3 Ph-4 - 0(L-21d) H Η C(CH3) 2ch2so2ch3 ch3 Ph-4-0 (L-21e) H Η C(CH3) 2ch2so2ch3 ch3 Ph-4-0 (L - 45c) H Η C(CH3) 2ch2so2ch3 ch3 Ph-4-0 (L-45d) H Η c(ch3) 2ch2so2ch3 ch3 Ph-3-0 (L-45e) H Η c(ch3)2ch2so2ch3 ch3 Ph-4-0 (L-45e) H Η C(CH3) 2ch2so2ch3 ch3 Ph-4-0 (L-45f) H Η c(ch3) 2ch2so2ch3 ch3 Ph-4-0 (L-48b) H Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph-4-0 (L-45e) H Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph - 4-0(L-451) H Η CH (CH3)CH2N(CH3)S02CH3 ch3 Ph-4 -0 (L-48b&gt; H Η CH (CH3) CH=N0CH3 ch3 Ph - 4-0 (L-45e) H Η CH(CH3)CH=NOCH3 ch3 Ph&quot;4~0 (L~451) H Η CH (CH3)CH=N0CH3 ch3 Ph - 4-0 (L-48b&gt; H Η C(CH3)2CH=NOCH3 ch3 Ph - 4-0 (L - 45e) H Η C(CH3)2CH=N0CH3 ch3 Ph-4-0 (L-451) H Η C(CH3) 2ch=noch3 ch3 Ph-4 - 0 (L-48b) H
489 314918 200407073
Η C{CH3)2C=CH ch3 Ph+0 (L - 45c) H Η C{CH3)2C=CH ch3 Ph-4-0 (L-45d) H Η C(CH3)2C=CH ch3 Ph-4-0 (L-45e) H Η C(CH3)2C^CH ch3 Ph - 4-0(L - 451) H Η C(CH3)2C-CH ch3 Ph - 4-0 (L - 48b) H 下述第5表中，表示取代基（X)m及（Y)n之取代位置之 編號，分別對應於下述構造式中記載之編號之位置。 490 314918 2〇〇4〇7〇73
491 200407073
[4]· 9 , [4]-10
492 314918 200407073
493 314918 200407073
[4]-21 ， [4】-22
[4]-23 494 3]4918 200407073 (®m (Y)n R4 R6J R6k R61 R5 5-F 2-CH3 cf3 Cl Cl H Ph-4-F 5-F 2 - CH3 Ph+0CF3 F F H H 6-F 2 - CH3 cf3 Cl Cl H Ph~4~F 6_F 2 - CH3 cf3 Cl Cl H Ph-4-Cl 6-F 2-CH3 cf3 Cl Cl H Ph~4~Br 6-F 2-CH3 cf3 Cl Cl H Ph-4-CF3 6-F 2-CH3 cf3 Cl Cl H Ph-4-0CHF2 6~F 2-CH3 cf3 Cl Cl H Ph-4-0CF3 6 -F 2 - CH3 cf3 Cl Cl H Ph~4-S02CH3 6-F 2-CHa cf3 Cl Cl H L-46d 6-F 2-CH3 Ph-4-F F F H H 6-F 2 - CH3 Ph-4-Cl F F H H 6-F 2-CH3 Ph-4-Br F F H H 6-F 2-CH3 Ph-4-CF3 F F H H 6-F 2-CH3 Ph-4-OCHF 2 F F H H 6-F 2 - CH3 Ph+0CF3 F F H H 6-F 2-CH3 Ph-4-0CF3 Cl Cl H H 6-F 2-CH3 Ph - 4 一0 (L-45g&gt; F F H H 6_F 2 - CH3 Ph-3, 4-C12 F F H H 6-F 2-CH3 L - 46d F F H H 3, 4-F2 2-CH3 cf3 H H H Ph+Cl 3, 4-F2 2-CH3 cf3 H H H Ph-4-0CF3 3, 4-F2 2-CH3 cf3 Cl Cl H Ph-4-F 3,4-F2 2-CH3 cf3 Cl Cl H Ph-4-Cl 3, 4-F2 2-CH3 cf3 Cl Cl H Ph-4-Br 3,4-F2 2-CH3 cf3 Cl Cl H Ph-4-CF3 3, 4-F2 2-CH3 cf3 Cl Cl H Ph-4-0CHF2 3, 4-F2 2 - CH3 cf3 Cl Cl H Ph+0CF3 3, 4-F2 2-CH3 cf3 Cl Cl H Ph-4-0S02CH3 3· 4_F2 2-CHa cf3 Cl Cl H Ph-4-SCH3 3, 4-F2 2-CH3 cf3 Cl Cl H Ph+S(0)CH3 3, 4-F2 2 - CH3 cf3 Cl Cl H Ph+S02CH3 3. 4-F2 2 - CH3 cf3 Cl Cl H Ph+CN 3,4-F2 2 - CH3 cf3 Cl Cl H Ph-3,4-Cl2 495 314918 200407073
3, 4-F2 2-CH3 cf3 Cl Cl H L-46d 3, 4-F2 2~CH3 cf3 Cl Cl H L-47e 3, 4-F2 2-CH3 Ph-4-F F F H H 3, 4-F2 2-CH3 Ph+Cl F F H H 3, 4-F2 2 - CH3 Ph-4-Cl Cl Cl H H 3, 4-F2 2-CH3 Ph-4-Br F F H H 3, 4-F2 2-CH3 Ph-4-CF3 F F H H 3,4-F2 2-CH3 Ph-4-0CHF2 F F H H 3, 4-F2 2-CH3 Ph-4-0CHF2 Cl Cl H H 3, 4-F2 2-CH3 Ph-4-0CF3 H H H H 3, 4-F2 2-CH3 Ph-4-0CF3 F F H H 3, 4-F2 2-CH3 Ph-4-OCFa Cl Cl H H 3, 4-F2 2-CH3 Ph-4_0CF3 Br Br H H 3, 4-F2 2-CH3 Ph-4-0CF3 CN CN H H 3, 4_F2 2 - CH3 Ph-4 - 0 (L-45g) F F H H 3, 4-F2 2-CH3 Ph - 4-0 (L—45g) Cl Cl H H 3, 4-F2 2-CH3 Ph-4-CN F F H H 3, 4-F2 2 - CH3 Ph-3, 4-Cl2 F F H H 3, 4-F 2 2-CH3 L-46d F F H H 4, 5-F2 2 - CH3 cf3 Cl Cl H Ph-4-Cl 4, 5-F2 2-CH3 Ph-4-0CF3 F F H H 3, 6-F2 2-CH3 Ph-4-0CF3 F F H H 4-C1 2 - CH3 cf3 Cl Cl H Ph-4-Cl 4-Cl 2-CH3 Ph-4-0CF3 F F H H 5-C1 2-CH3 Ph+0CF3 F F H H 6-C1 2 - CH3 cf3 Cl Cl H Ph-4-F 6-Cl 2 - CH3 cf3 Cl Cl H Ph+Cl 6 - Cl 2 - CH3 cf3 Cl Cl H Ph~4-Br 6-C1 2-CH3 cf3 Cl Cl H Ph-4-CF3 6~C1 2-CH3 cf3 Cl Cl H Ph+0CHF2 6 - Cl 2 - CH3 cf3 Cl Cl H Ph-4-0CF3 6-C1 2-CH3 cf3 Cl Cl H Ph+S02CH 6-C1 2-CH3 cf3 Cl Cl H L-46d 6-Cl 2 - CH3 Ph-4-F F F H H 6~C1 2-CH3 Ph+Cl F F H H 6-C1 2-CH3 Ph~4~Br F F H H 6 - Cl 2 - CH3 Ph-4-CF 3 F F H H 496 314918 200407073
6-C1 2-CH3 Ph-4-0CHF2 F F H H 6-Cl 2-CH3 Ph-4-0CF3 F F H H 6~C1 2 - CH3 Ph-4-0CF 3 Cl Cl H H 6-C1 2~CH3 Ph-4~0 (L~45g) F F H H 6-Cl 2-CH3 Ph-3,4-Cl2 F F H H 6-C1 2-CH3 L - 46d F F H H 3-Cl~4~F 2-CH3 cf3 H H H Ph-4-Cl 3-C1-4-F 2-CH3 cf3 H H H Ph-4-0CF3 3-C1-4-F 2-CH3 cf3 Cl Cl H Ph-4-F 3-Π - 4 -F 2-CH3 cf3 Cl Cl H Ph+Cl 3-C1-4-F 2-CH3 cf3 Cl Cl H Ph+Br 3 普 4-F 2-CH3 cf3 Cl Cl H Ph-4-CF3 3-C1-4-F 2-CH3 cf3 Cl Cl H Ph-4~0CHF2 2-CH3 cf3 Cl Cl H Ph-4-0CF3 3-C1-4-F 2-CH3 cf3 Cl Cl H Ph-4-0S02CH 3-C1-4-F 2~CH3 cf3 Cl Cl H Ph+SCH3 3-C1-4-F 2-CH3 cf3 Cl Cl H Ph-4-S(0) CH： 3-C1-4-F 2-CH3 cf3 Cl Cl H Ph-4-S02CH3 3-C1-4-F 2-CH3 cf3 Cl Cl H Pb+CN 3_C卜4-F 2-CH3 cf3 Cl Cl H Ph-3,4-Cl2 3-C卜4-F 2-CH3 cf3 Cl Cl H L-46d 3~C1~4~F 2 - CH3 cf3 Cl Cl H L - 47e 3_C卜4-F 2-CH3 Ph-4-F F F H H 3-C1-4-F 2-CH3 Ph-4-C1 F F H H 3-C 卜4 -F 2-CH3 Ph+Cl Cl Cl H H 3-C 卜4 -F 2~CH3 Ph-4-Br F F H H 3-C1-4-F 2-CH3 Ph-4-CF3 F F H H 3~C1~4~F 2 - CH3 Ph-4-0CHF2 F F H H 3-Cl_4-F 2-CH3 Ph-4~0CHF2 Cl Cl H H 3~C1，4，F 2-CH3 Ph-4-OCFa H H H H 3 普 4-F 2-CH3 Ph-4-0CF3 F F H H 3-C1-4-F 2-CH3 Ph-4-0CF3 Cl Cl H H 3-C1-4-F 2-CH3 Ph-4-0CF3 Br Br H H 3-C 卜4-F 2 - CH3 Ph-4-0CF3 CN CN H H 3-Ci+F 2-CH3 Ph - 4-0 (L_45g) F F H H 3-C卜4-F 2-CH3 Ph-4-0 (L-45g) Cl Cl H H 3-C 卜4-F 2 - CH3 Ph+CN F F H H 497 314918 200407073
3-C1-4-F 2 - CH3 Ph-3,4-(：12 F F H H 3-C卜4-F 2-CH3 L-46d F F H H 3, 4-Cl2 2-CH3 cf3 H H H Ph-4-Cl 3, 4-Cl2 2-CH3 cf3 H H H Ph+0CF3 3,4-Cl2 2-CH3 cf3 Cl Cl H Ph-4-F 3,4-Cl2 2 - CH3 cf3 Cl Cl H Ph-4-Cl 3, 4-Cl 2 2-CH3 cf3 Cl Cl H Ph+Br 3, 4-Cl2 2-CH3 cf3 Cl Cl H Ph二4-CF3 3,4-Cl2 2-CH3 cf3 Cl Cl H Ph-4~0CHF2 3, 4-Cl 2 2-CH3 cf3 Cl Cl H Ph-4-0CF3 3,4-Cl2 2-CH3 cf3 Cl Cl H Ph-4-0S02CH 3, 4-Cl2 2-CH3 cf3 Cl Cl H Ph-4-SCH3 3, 4-Cl2 2-CH3 cf3 Cl Cl H Ph-4-S (0) CH； 3, 4-Cl 2 2-CH3 cf3 Cl Cl H Ph-4-S02CH3 3, 4-Cl2 2-CH3 cf3 Cl Cl H Ph+CN 3, 4-Cl2 2-CH3 cf3 Cl Cl H Ph-3, 4~C12 3,4-Cl2 2-CH3 cf3 Cl Cl H L-46d 3, 4-Cl 2 2-CH3 cf3 Cl Cl H L - 47e 3, 4-CI2 2~CH3 Ph+F F F H H 3, 4-Cl2 2-CH3 Ph-4-Cl F F H H 3. 4-Cl2 2-CH3 Ph-4-Cl Cl Cl H H 3, 4-Cl2 2 - CH3 Ph-4~Br F F H H 3, 4-Cl 2 2 - CH3 Ph-4-CF3 F F H H 3, 4-Cl 2 2 - CH3 Ph-4-0CHF2 F F H H 3, 4-Cl2 2 - CH3 Ph-4_0CHF2 Cl Cl H H 3, 4-Cl2 2 - CH3 Ph-4-0CF3 H H H H 3,4-CU 2 - CH3 Ph-4-0CF3 F F H H 3, 4-Cl2 2-CH3 Ph+0CF3 Cl Cl H H 3,4-Cl2 2-CH3 Ph-4-0CF3 Br Br H H 3,4-Cl2 2 - CH3 Ph+0CF3 CN CN H H 3, 4-Cl2 2-CH3 Ph-4-0 (L-45g) F F H H 3, 4-Cl 2 2-CH3 Ph-4-0 (L-45g) Cl Cl H H 3, 4-Cl 2 2-CH3 Ph-4-CN F F H H 3, 4-Cl 2 2-CH3 Ph-3, 4-Cl2 F F H H 3,4-Cl2 2~CH3 L-46d F F H H 3, 5-Cl 2 2-CH3 Ph~4~0CF3 F F H H 3,6-Cl2 2 - CH3 Ph-4-0CF3 F F H H
498 314918 200407073 5, 6-Cl2 2 - CH3 Ph-4-0CF3 F F H H 6 - Βγ 2 - CH3 cf3 Cl Cl H PH-F 6-Br 2-CH3 cf3 Cl Cl H Ph-4-Cl 6-Br 2 - CH3 cf3 Cl Cl H Ph+Br 6-Βγ 2-CH3 cf3 Cl Cl H Ph-4-CF3 6ΗΒγ 2-CH3 cf3 Cl Cl H Ph-4-0CHF2 6-Βγ 2-CH3 cf3 Cl Cl H Ph-4-0CF3 6-Βγ 2 - CH3 cf3 Cl Cl H Ph-4-S02CH3 6-Βγ 2-CH3 cf3 Cl Cl H L - 46d 6-Br 2-CH3 Ph~4~F F F .H H 6 - Βγ 2-CH3 Ph+Cl F F H H 6-Βγ 2-CH3 Ph~4~Br F F H H 6-Βγ 2-CH3 Ph-4-CF3 F F H H 6-Βγ 2-CH3 Ph-4-0CHF2 F F H H 6-Βγ 2-CH3 Ph-4-0CF3 F F H H 6-Βγ 2-CH3 Ph-4-OCFa Cl Cl H H 6-Βγ 2~CH3 Ph~4~0 (L~45g) F F H H 6-Βγ 2-CH3 Ph-3, 4-Cl2 F F H H 6~Βγ 2-CH3 L - 46d F F H H 3, 4-Βγ2 2 - CH3 cf3 Cl Cl H Ph-4-Cl 3, 4-Βγ2 2-CH3 Ph-4-Cl F F H H 3, 4-Βγ2 2 - CH3 Ph-4-Cl Cl Cl H H 3, 4-Βγ2 2-CH3 Ph-4-0CF3 F F H H 3,4-Βγ2 2-CH3 Ph-4-0CF3 Cl Cl H H 3,4-Βγ2 2-CH3 Ph-4-0 a-45g) F F H H 3, 4-Βγ2 2-CH3 Ph-4-0 (L-45g) Cl Cl H H 3, 6-Βγ2 2-CH3 cf3 Cl Cl H Ph-4-Cl 3, 6-Βγ 2 2-CH3 Ph-4-0CF3 F F H H 5, 6-Βγ 2 2-CH3 Ph-4~0CF3 F F H H 3-1 2-CH3 H F F F Ph-4-Cl 3-1 2-CH3 H F F F Ph-4-S02CH3 3-1 2-CH3 H F F Cl Ph-4-Cl 3-1 2-CH3 H F F Cl Ph-4_S02CH3 3-1 2 - CH3 H F F Br Ph-4-Cl 3-1 2-CH3 H F F Br Ph-4-S02CH3 3-1 2-CH3 H Cl Cl F Ph-4-Cl 3-1 2 - CH3 H Cl Cl F Ph-4-S02CH3 499 314918 200407073
3-1 2 - CH3 Η Cl Cl Cl Ph+Cl 3-1 2-CH3 Η Cl Cl Cl Ph-4-S02CH3 3-1 2-CH3 Η Cl Cl Br Ph+Cl 3-1 2-CH3 Η Cl Cl Br Ph+S02CH3 3-1 2-CH3 Η ch3 H H Ph+Cl 3-1 2 - CH3 Η ch3 ch3 H Ph-4-Cl 3-1 2-CH3 Η CN CN H Ph-4-Cl 3-1 2 - CH3 Η CN CN H Ph-4OCF3 3-1 2-CH3 F H H Cl Ph-4-Cl 3-1 2-CH3 F H H Br Ph+Cl 3-1 2 - CH3 F CN CN H H 3-1 2-CH3 C1 H H Cl Ph-4-Cl 3-1 2-CH3 C1 H H Br Ph-4-Cl 3-1 2 - CH3 C1 CN CN H H 3-1 2-CH3 Βγ H H Cl Ph-4-Cl 3-1 2-CH3 Βγ H H Br Ph-4-Cl 3-1 2-CHa Βγ F F Cl Ph-4-Cl 3-1 2-CH3 Βγ F F Br Ph+Cl 3-1 2-CH3 Βγ CN CN H H 3-1 2-CH3 ch3 H H Cl Ph-4-Cl 3-1 2-CH3 ch3 H H Br Ph+Cl 3-1 2-CHa ch3 ch3 H H Ph-4-Cl 3-1 2 - CH3 ch3 ch3 ch3 H Ph+Cl 3-1 2 - CH3 ch3 CN CN H H 3-1 2-CH3 ch3 CN CN H Ph-4-Cl 3-1 2-CH3 ch3 CN CN H Ph-4-0CF3 3-1 2-CH3 Et ch3 H H Ph-4-Cl 3-1 2-CH3 Et CN CN H H 3-1 2-CH3 n-Pr ch3 H H Ph-4-Cl 3-1 2-CH3 n-Pr CN CN H H 3-1 2-CH3 卜Pr ch3 H H Ph+Cl 3-1 2-CH3 i-Pr CN CN H H 3-1 2-CH3 -CH2CH2CH2- H H Ph-4-Cl 3-1 2-CH3 -ch2ch2ch2- H F F 3-1 2-CH3 -ch2ch2ch2- H Cl Cl 3-1 2 - CH3 -ch2ch2ch2ch2- H H Ph-4-Cl 3-1 2-CH3 -ch2ch2ch2ch2- H F F
500 314918 200407073
3-1 2 - CH3 -ch2ch2ch2ch2- H Cl Cl 3-1 2-CH3 chf2 H H Cl Ph-4-Cl 3-1 2-CH3 chf2 H H Br Ph-4-Cl 3-1 2 - CH3 chf2 ch3 H H Ph+Cl 3-1 2-CH3 chf2 ch3 ch3 H Ph+Cl 3-1 2 - CH3 chf2 CN CN H H 3-1 2-CH3 cf3 H H Cl Ph-4-F 3-1 2-CH3 cf3 H H Cl Ph-4-Cl 3-1 2-CH3 cf3 H H Cl Ph-4-Br 3-1 2 - CH3 cf3 H H Cl Ph-4-0CF 3-1 2 - CH3 cf3 H H Br Ph-4-F 3-1 2-CH3 cf3 H H Br Ph+Cl 3-1 2 - CH3 cf3 H H Br Ph-4-Br 3-1 2 - CH3 cf3 H H Br Ph-4-OCF 3-1 2 - CH3 cf3 ch3 H H Ph-4-F 3-1 2-CH3 cf3 ch3 H H Ph+Cl 3-1 2-CH3 cf3 ch3 H H Ph-4-Br 3-1 2 - CH3 cf3 ch3 H H Ph-4-OCF 3-1 2 - CH3 cf3 ch3 ch3 H Ph-4-F 3-1 2 - CH3 cf3 ch3 ch3 H PH-Cl 3-1 2-CH3 cf3 ch3 ch3 H Ph-4-Br 3-1 2-CHa cf3 ch3 ch3 H Ph-4-0CF 3-1 2 - CH3 cf3 Et H H Ph-4-Cl 3-1 2 - CH3 cf3 n-Pr H H Ph-4-C1 3-1 2-CH3 cf3 i - Pr H H Ph-4-Cl 3-1 2-CH3 cf3 CN CN H H 3-1 2-CH3 cf3 CN CN H Ph-4-Cl 3-1 2 - CH3 cf3 CN CN H Ph-4-0CF 3-1 2 - CH3 cf2ci ch3 H H PH-Cl 3-1 2-CH3 cf2ci CN CN H H 3-1 2-CH3 cf2cf3 ch3 H H Ph-4-Cl 3-1 2-CH3 cf2cf3 CN CN H H 3-1 2 - CH3 ch2och3 CN CN H H 3-1 2-CH3 CH20Et CN CN H H 3Ί 2 - CH3 ch2och2cf3 F H H H 3-1 2-CH3 ch2och2cf3 Cl H H H 3-1 2 - CH3 ch2och2cf3 Br H H H
50] 314918 200407073
3-1 2 - CH3 ch2och2cf3 CN 3-1 2 - CH3 ch2och2cf2cf3 F 3-1 2 - CH3 ch2och2cf2cf3 Cl 3-1 2-CH3 ch2och2cf2cf3 Br 3-1 2~CH3 ch2och2cf2cf3 CN 3-1 2-CH3 cf2ocf2cf2ocf3 F 3-1 2-CH3 cf2ocf2cf2ocf3 Cl 3-1 2 - CH3 cf2ocf2cf2ocf3 Br 3-1 2-CH3 cf2ocf2cf2ocf3 CN 3-1 2 - CH3 ch2sch3 CN 3-1 2-CH3 ch2so2ch3 CN 3-1 2-CH3 CH2SEt CN 3-1 2-CH3 ch2scf3 F 3-1 2-CH3 ch2scf3 Cl 3-1 2 - CH3 ch2scf3 Br 3-1 2 - CH3 ch2scf3 CN 3-1 2-CH3 och3 CN 3-1 2-CH3 SPh CN 3-1 2-CH3 T_22 F 3-1 2 - CH3 T-22 Cl 3-1 2-CH3 T-22 Br 3-1 2-CH3 T-22 CN 3-1 2-CH3 T-23 F 3-1 2-CH3 T - 23 Cl 3-1 2-CH3 T-23 Br 3-1 2-CH3 T-23 CN 3-1 _2-CH3 T-24 F 3-1 2-CH3 T - 24 Cl 3-1 2-CH3 T-24 Br 3-1 2-CH3 T-24 CN 3-1 2~CH3 Ph一4，f F 3-1 2-CH3 Ph-4-F Cl 3-1 2-CH3 Ph-4-F Br 3-1 2-CH3 Ph - 4*~F Br 3-1 2 - CH3 Ph - 4HF CN 3-1 2-CH3 Ph+Cl F 3-1 2-CH3 Ph-4-Cl F
CN Η Η Η Η Η CN Η Η CN Η Η CN Η Η Η Η Η C1 Η Η CN Η Η Η Η Η Η CH3 Η 502 314918 200407073 3-1 2-CH3 Ph+Cl 3-1 2-CH3 Ph-4-Cl 3-1 2~CH3 Ph-4-Cl 3-1 2-CH3 Ph-4-Cl 3-1 2-CH3 Ph-4-Cl 3-1 2-CH3 Ph-4-Cl 3-1 2-CH3 Ph-4-Cl 3-1 2-CH3 Ph-4-Cl 3-1 2-CH3 Ph+Cl 3-1 2-CH3 Ph+Cl 3-1 2-CH3 Ph-4-Cl 3-1 2-CH3 PH-C1 3-1 2-CH3 Ph+Cl 3-1 2-CH3 Ph-4-Cl 3-1 2 - CH3 Ph-4-C1 3-1 2 - CH3 Ph+Cl 3-1 2-CH3 Ph+Cl 3-1 2-CH3 Ph_4-Cl 3-1 2-CH3 Ph-4-Cl 3*1 2-CH3 Ph-4-Br 3-1 2-CH3 Ph+Br 3-1 2-CH3 Ph-4-CF3 3-1 2 - CH3 Ph-4-CF3 3-1 2-CH3 Ph-4-0CHF2 3-1 2-CH3 Ph-4-0CHF2 3-1 2 - CH3 Ph-4-OCFs 3-1 2 - CH3 Ph+0CF3 3-1 2-CH3 Ph-4-OCFa 3-1 2-CH3 Ph-4-OCFa 3-1 2-CH3 Ph-4-0CF3 3-1 2-CH3 Ph-4-0CF3 3-1 2-CH3 Ph-4-0CF3 3-1 2-CH3 Ph-4-0CF3 3-1 2 - CH3 Ph-4-0CF3 3-1 2 - CH3 Ph-4-0CF3 3-1 2-CH3 Ph-4~0CF 3 3-1 2-CH3 Ph-4-0CF3 F F F Η
F F F F F F F Cl F F F Br
F F Cl H F F Cl Cl
F F Br H F F Br Br
F F CH3 H
F Cl CH3 H
F Br CH3 H
Cl Η Η H
Cl H CH3 H
Cl Cl CH3 H
Br Η Η H
Br H CH3 H
Br Cl Η H
Br Br CH3 H
CN CN Η H
Br Cl Η H
CN CN Η H
Br Cl Η H
CN CN Η H
Br Cl Η H
CN CN Η H
F Η Η H
F H CH3 H
F F F H
F F F F F F F Cl F F F Br
F F Cl H F F Cl Cl
F F Br H F F Br Br
F F CH3 H
F Cl CH3 H
503 314918 200407073 3-1 2-CH3 Ph-4-0CF3 F Br ch3 H 3~I 2~CH3 Ph+0CF3 Cl H H H 3-1 2爲 Ph~4~0CF 3 Cl H ch3 H 3-1 2-CH3 Ph-4-0CF3 Cl Cl ch3 H 3-1 2-CH3 Ph-4**0CF 3 Br H H H 3-1 2-CH3 Ph+0CF3 Br -H ch3 H 3-1 2-CH3 Ph-4-0CF3 Br Cl H H 3-1 2-CH3 Ph+0CF3 Br Br ch3 H 3-1 2 - CH3 Ph-4-0CF3 CN CN H H 3-1 2-CH3 Ph-4-0CF2Br Br Cl H H 3-1 2-CH3 Ph-4-0CF2Br CN CN H H 3-1 2-CH3 Ph-4-0CF2CHF2 Br Cl H H 3-1 2 - CH3 Ph-4-0CF2CHF2 CN CN H H 3-1 2-CH3 Ph-4-0CF2CHFCF3 Br Cl H H 3-1 2-CH3 Ph-4-0CF2CHFCF3 CN CN H H 3-1 2-CH3 Ph-4-0CF2CHF0CF3 Br Cl H H 3-1 2-CH3 Ph-4-0CF2CHF0CF3 CN CN H H 3-1 2-CH3 Ph-4-0 (L-45g) F H H H 3-1 2-CH3 Ph-4-0 (L - 45g) Cl H H H 3-1 2-CH3 Ph-4-0 (L-45g) Br H H H 3-1 2-CH3 Ph-4-0(L-45g) Br Cl H H 3-1 2-CH3 Ph-4-0 a-45g) CN CN H H 3-1 2-CH3-3-F H H H H Ph-4-Cl 3-1 2-CH3+F H H H H Ph+Br 3-1 2-CH3-3-F H H H H Ph-4-0CF3 3-1 2-CH3+F H H H H Ph-4-S02CH3 3-1 2 - CH3+F H H H Cl Ph-4-C1 3-1 2-CH3-3-F H H H Br Ph-4-Cl 3-1 2-CH3+F H F F H Ph-4-Cl 3-1 2-CH3-3-F H F F Cl Ph+Cl 3-1 2-CH3-3-F H F F Br Ph-4-Cl 3-1 2-CH3-3-F H F Cl H Ph+Cl 3-1 2-CH3+F H F Br H Ph-4-Cl 3-1 2-CH3-3-F H Cl Cl H Ph+Cl 3-1 2_CH3+F H Br Br H Ph-4-Cl 3-1 2-CH3-3-F H CN CN H Ph-4-Cl 3-1 2-CH3+F cf3 H H H Ph+Cl 504 314918 200407073 3-1 2-CH3+F cf3 H H H Ph+Br 3-1 2-CH3-3HF cf3 H H H Ph-4-0CF3 3-1 2 - CH3+F cf3 H H H ph_so2ch3 3-1 2-CH3+F cf3 H H Cl Ph+Cl 3-1 2-CH3+F cf3 H H Br Ph+Cl 3-1 2-CH3+F H H H H Ph-4-Cl 3-1 2 - CH3+F H H H H Ph-4-Br 3-1 2-CH3+F H H H H Ph-4-0CF3 3-1 2-CH3-5-F H H H H Ph-4-S02CH3 3-1 2-CH3-5-F cf3 H H H Ph-4-Cl 3-1 2-CH3-3-CI H H H H Ph-4-Cl 3-1 2~CH3+C1 H H H H Ph+Br 3-1 2-CH3-3-Cl H H H H Ph-4-OCF 3 3-1 2~CH3-3-Cl H H H H Ph-4-S02CH3 3-1 2-CH3-3-Cl H H H Cl Ph+Cl 3-1 2-CH3-3-CI H H H Br Ph+Cl 3-1 2-CH3-3-CI H F H H Ph-4-C1 3-1 2-CH3+Cl H F F H Ph-4-Cl 3-1 2-CH3+Cl H F F Cl Ph-4-Cl 3-1 2-CH3-3-CI H F F Br Ph-4-Cl 3-1 2-CH3+Cl H F Cl H Ph+Cl 3-1 2-CH3-3-CI H F Br H Ph+Cl 3-1 2 - CH3+C1 H Cl H H Ph+Cl 3~I 2-CH3+Cl H Cl Cl H Ph+Cl 3-1 2-CH3-3-C1 H Br H H Ph-4-Cl 3-1 2 - CH3+C1 H Br Br H Ph+Cl 3-1 2 - CH 3-3-Cl H CN CN H Ph-4-Cl 3-1 2-CH3-5-Cl H H H H Ph-4-Cl 3-1 2-CH3-5-CI H H H H Ph-4-Br 3-1 2 - CH3+C1 H H H H Ph-4-0CF3 3-1 2-CH3-5-C1 H H H H Ph-4-S02CH3 3-1 2-CH3+Cl cf3 H H H Ph+Cl 3-1 2, 3- (CH3)2 H H H H Ph-4-Cl 3-1 2,3-(CH3)2 H H H H Ph-4-Br 3-1 2, 3- (CH3)2 H H H H Ph-4-0CF3 3-1 2,3-(CH3)2 H H H H Ph-4-S02CH3 3-1 2, 5- (CH3)2 H H H H Ph+Cl
505 314918 200407073 3-1 2,5-(CH3)2 H H 3-1 2,5-(CH3)2 H H 3-1 2,5- (CH3)2 H H 3-1 2, 5- (CH3)2 cf3 H 3-1 2,6-(CH3)2 H H 3-1 2-CH3-3-OCH3 H H 3-1 2-CH3-3-0CHF2 H H 3-1 2-CH3-3, 5-Cl2 H H 4-1 2 - CH3 cf3 Cl 4-1 2-CH3 Ph-4-0CF3 F 5-1 2-CH3 Ph-4-0CF3 F 6-1 2-CH3 cf3 Cl 6-1 2-CH3 cf3 Cl 6-1 2-CH3 cf3 Cl 6-1 2-CH3 cf3 Cl 6-1 2-CH3 cf3 Cl 6-1 2-CH3 cf3 Cl 6-1 2 - CH3 cf3 Cl 6·Ι 2-CH3 cf3 Cl 6-1 2-CH3 cf3 Cl 6-1 2-CH3 Ph-4-F F 6-1 2-CH3 Ph-4-Cl F 6-1 2 - CH3 Ph+Br F 6-1 2-CH3 Ph-4-CF3 F 6-1 2-CH3 Ph-4-0CHF2 F 6-1 2-CH3 Ph-4-0CF3 F 6-1 2-CH3 Ph-4-OCFs Cl 6-1 2-CH3 Ph-4~〇a-45g) F 6-1 2-CH3 Ph-3. 4-Cl2 F 6-1 2-CH3 L-46d F 3+4-C1 2-CH3 Ph-4-0CF3 F 4普 6-1 2-CH3 Ph-4-0CF3 F 3-CH3 2 - CH3 cf3 Cl 3-CHa 2 - CH3 cf3 Cl 3 - CH3 2-CH3 cf3 Cl 3-CHa 2-CH3 cf3 Cl 3-CH3 2-CH3 cf3 Cl
Ph+Br H H Ph-4-0CF3 H H Ph-4-S02CH3 H H Ph-4-Cl H H Ph+Cl H H Ph-4-Cl H H Ph+Cl H H Ph-4-Cl Cl H Ph-4-Cl F H H F H H Cl H Ph-4-F Cl H Ph-4-Cl Cl H Ph-4-Br Cl H Ph-4-CF3 Cl H Ph-4~0CHF2 Cl H Ph-4-0CF3 Cl H Ph-4-S02CH3 Cl H Ph-3,4—Cl2 Cl H L-46d F H H F H H F H H F H H F H H F H H Cl H H
F H H F H H F H H Cl H Ph-4-F Cl H Ph-4-Cl Cl H Ph-4-Br Cl H Ph+CF3 Cl H Ph-4-OCHF 506 314918 200407073
3 - CH3 2-CH3 cf3 Cl Cl H Ph-4-0CF3 3-CH3 2-CH3 cf3 Cl Cl H Ph-4-SCH3 3-CH3 2-CH3 cf3 Cl Cl H Ph-4-S (0) CH 3-CH3 2-CH3 cf3 Cl Cl H Ph-4-S02CH3 3-CH3 2-CH3 Ph+F F F H H 3-CH3 2-CH3 Ph-4-Cl F F H H 3-CHa 2 - CH3 Ph+Cl Cl Cl H H 3 - CH3 2-CH3 Ph~4~Br F F H H 3 - CH3 2 - CH3 Ph-4-CF3 F F H H 3-CH3 2-CH3 Ph-4-0CHF2 F F H H 3-CH3 2-CH3 Ph-4-0CF3 H H H H 3-CHa 2-CH3 Ph-4-0CF3 F F H H 3~CH3 2-CH3 Ph-4-0CF3 F Cl H H 3-CH3 2 - CH3 Ph-4-0CF3 F Br H H 3-CH3 2-CH3 Ph+0CF3 Cl Cl H H 3-CHa 2-CH3 Ph-4-0CF3 Br Br H H 3-CHa 2 - CH3 Ph-4-0CF3 CN CN H H 3 - CH3 2 - CH3 Ph-4-0 (L-45g) F F H H 3-CH3 2-CH3 Ph-4-0 (L-45g) Cl Cl H H 3-CHa 2 - CH3 Ph-4-CN F F H H 3-CHa 2-CH3 Ph-3, 4-Cl2 F F H H 3-CHa 2-CH3 L - 46d F F H H 5 - CH3 2 - CH3 Ph-4-OCF 3 F F H H 6-CH3 2 - CH3 Ph-4-0CF3 F F H H 3-Cl~4-CH3 2 - CH3 cf3 Cl Cl H Ph+Cl 3-C卜4爲 2 - CH3 Ph+0CF3 F F H H 3-Et 2-CH3 Ph-4-0CF3 F F H H 6-Et 2-CH3 Ph-4-0CF3 F F H H 3-CF3 2-CH3 cf3 Cl Cl H Ph~4-F 3-CF: 3-CF, 3-CF, 3-CF; 3-CF, 3 - CF: 3-CF, 3-CF, 2-CH3 2-CH3 2 - CH3 2-CH3 2-CH3 2-CH3 2 - CH3 2 - CH3 CF： cf2 CF: CF, cf5 CF: CF: CF,
Cl Cl Cl Cl Cl Cl Cl Cl
Cl Cl Cl Cl Cl Cl Cl Cl
Ph-4-Cl Ph-4-Br Ph-4-CF3 Ph-4-0CHF2 Ph-4-0CF3 Ph-4-0S02CH, Ph-4-SCH3 Ph-4-S (0) CH3 507 314918 200407073
3-CF3 2 - CH3 cf3 Cl Cl H 3-CF3 2-CH3 cf3 Cl Cl H 3 - CF3 2-CH3 cf3 Cl Cl H 3 - CF3 2-CH3 cf3 Cl Cl H 3-CF3 2 - CH3 cf3 Cl Cl H 3 - CF3 2~CH3 Ph-4-F F F H 3 - CF3 2-CH3 Ph-4-F Cl Cl H 3 - CF3 2 - CH3 Ph-4-Cl F F H 3-CFa 2 - CH3 Ph-4-Cl F Cl H 3-CF3 2-CH3 Ph-4-Cl Cl Cl H 3-CF3 2-CH3 Ph-4-Br F F H 3-CFa 2-CH3 Ph-4-Br Cl Cl H 3 - CF3 2~CH3 Ph+CF3 F F H 3-CFa 2-CH3 Ph+CF3 Cl Cl H 3 - CF3 2-CH3 Ph-4-0CHF2 F F H 3 - CF3 2-CH3 Ph-4~0CHF2 Cl Cl H 3-CFa 2-CH3 Ph-4-0CF3 H H H 3-CFa 2-CH3 Ph-4-0CF3 F F H 3-CFa 2-CH3 Ph-4-0CF3 F Cl H 3-CFa 2-CH3 Ph-4-OCFa F Br H 3-CF3 2爲 Ph-4-OCF 3 Cl Cl H 3-CFa 2-CH3 Ph-4-0CF3 Br Br H 3 - CF3 2-CH3 Ph-4-0CF3 CN CN H 3 - CF3 2-CH3 Ph~4~0CF2Br F F H 3 - CF3 2-CH3 Ph-4-0CF2CHF2 F F H 3-CFa 2~CH3 Ph-4-0CF2CHFCF3 F F H 3 - CF3 2-CH3 Ph-4-0 (L-45g) F F H 3-CFa 2 - CH3 Ph-4-0 (L - 45g) F Cl H 3 - CF3 2-CH3 Ph - 4 -0 (L-45g&gt; Cl Cl H 3 - CF3 2-CH3 Ph-4-CN F F H 3 - CF3 2-CH3 Ph-3,4-Cl2 F F H 3-CFa 2-CH3 L-46d F F H 4 - CF3 2-CH3 Ph-4~0CF3 F F H 6-CF3 2-CH3 Ph-4-OCF3 F F H 3-CF2CF3 2 - CH3 Ph-4-0CF3 F F H 3-0CH3 2-CH3 cf3 Cl Cl H 3-0CH3 2 - CH3 Ph-4-OCF 3 F F H
Ph-4-S02CH3
Ph-4-CN
Ph-3,4-Cl2 L-46d L-47e
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
Ph-4-Cl
H
508 314918 200407073
6-0CH3 2 - CH3 cf3 Cl Cl H Ph-4-Cl 6-0CH3 2-CH3 Ph-4-OCFa F F H H 3-CI-4-OCH3 2-CH3 Ph-4-0CF3 F F H H 3-0CH20-4 2-CH3 Ph-4-0CF3 F F H H 3-0CHF2 2-CH3 cf3 Cl Cl H Ph-4-F 3-0CHF2 2-CH3 cf3 Cl Cl H Ph-4-Cl 3-0CHF2 2-CH3 cf3 Cl Cl H Ph~4~Br 3-0CHF2 2 - CH3 cf3 Cl Cl H Ph-4-CF3 3-0CHF2 2 - CH3 cf3 Cl Cl H Ph-4-0CHF2 3-0CHF2 2-CH3 cf3 Cl Cl H Ph-4-0CF3 3-0CHF2 2-CH3 cf3 Cl Cl H Ph-4-0S02CH 3-0CHF2 2-CH3 cf3 Cl Cl H Ph-4-SCH3 3-0CHF2 2-CH3 cf3 Cl Cl H Ph+S ⑼ CH: 3-0CHF2 2 - CH3 cf3 Cl Cl H Ph-4-S〇2CH3 3-0CHF2 2-CH3 cf3 Cl Cl H Ph-4-CN 3-0CHF2 2 - CH3 cf3 Cl Cl H Ph-3, 4-Cl2 3-0CHF2 2-CH3 cf3 Cl Cl H L-46d 3~0CHF2 2-CH3 cf3 Cl Cl H L-47e 3-0CHF2 2-CHa Ph+F F F H H 3-0CHF2 2-CH3 Ph-4-F Cl Cl H H 3-0CHF2 2-CH3 Ph-4-Cl F F H H 3-0CHF2 2-CH3 Ph-4-C1 F Cl H H 3-0CHF2 2 - CH3 Ph-4-Cl Cl Cl H H 3-0CHF2 2 - CH3 Ph+Br F F H H 3-0CHF2 2-CH3 Ph-4-Br Cl Cl H H 3-0CHF2 2 - CH3 Ph+CF3 F F H. H 3-0CHF2 2-CH3 Ph-4-CF3 Cl Cl H H 3-0CHF2 2 - CH3 Ph-4-0CHF2 F F H H 3-0CHF2 2 - CH3 Ph-4-0CHF2 Cl Cl H H 3-0CHF2 2-CH3 Ph-4-0CF3 H H H H 3-0CHF2 2~CH3 Ph-4-0CF3 F F H H 3-0CHF2 2~CH3 Pli - 4 -0CF3 F Cl H H 3-0CHF2 2~CH3 PH - 0CF3 F Br H H 3-0CHF2 2 - CH3 Ph-4-0CF3 Cl Cl H H 3-0CHF2 2-CH3 Ph-4-0CF3 Br Br H H 3-0CHF2 2-CH3 Ph-4-0CF3 CN CN H H 3-0CHF2 2 - CH3 Ph-4-0CF2Br F F H H 509 314918 200407073
3-0CHF2 2-CH3 Ph-4-0CF2CHF2 F F 3-0CHF2 2-CH3 Ph-4-0CF2CHFCF3 F F 3-0CHF2 2-CH3 Ph-4-0 (L-45g) F F 3-0CHF2 2-CH3 Ph-4-0 (L-45g) F Cl 3-0CHF2 2~CH3 Ph-4-0 (L-45g) Cl Cl 3-0CHF2 2-CH3 Ph-4-CN F F 3-0CHF2 2-CH3 Ph-3,4-Cl2 F F 3-0CHF2 2 - CH3 L - 46d F F 5-0CHF2 2 - CH3 Ph-4-0CF3 F F 6-0CHF2 2 - CH3 Ph-4-0CF3 F F 3-0CF3 2-CH3 cf3 Cl Cl 3-OCF3 2-CH3 cf3 Cl Cl 3-OCF3 2-CH3 cf3 Cl Cl 3-OCF3 2-CH3 cf3 Cl Cl 3-OCFa 2 - CH3 cf3 Cl Cl 3-OCFa 2-CH3 cf3 Cl Cl 3-OCF3 2-CH3 cf3 Cl Cl 3-0CF3 2-CH3 cf3 Cl Cl 3-0CF3 2 - CH3 cf3 Cl Cl 3-OCF3 2 - CH3 cf3 Cl Cl 3-0CF3 2 - CH3 cf3 Cl Cl 3 - 0CF3 2-CH3 cf3 Cl Cl 3-OCF3 2-CH3 cf3 Cl Cl 3-OCF3 2 - CH3 cf3 Cl Cl 3-OCF3 2-CH3 Ph-4-F F F 3-OCF3 2 - CH3 Ph-4-F Cl Cl 3-0CF3 2 - CH3 Ph-4-Cl F F 3-0CF3 2-CH3 Ph-4-Cl F Cl 3 - 0CF3 2-CH3 Ph+Cl Cl Cl 3-OCF3 2-CH3 Ph-4-Br F F 3 - 0CF3 2-CH3 Ph+Br Cl Cl 3-OCFa 2-CH3 Ph-4-CF3 F F 3-OCF3 2-CH3 Ph-4-CF3 Cl Cl 3-0CF3 2-CH3 ’ Ph-4_0CHF2 F F 3-OCF3 2 - CH3 Ph-4-0CHF2 Cl Cl 3-0CF3 2-CH3 Ph-4-0CF3 H H 3-OCFa 2 - CH3 Ph-4-0CF3 F F Η Η Η Η Η Η Η Η Η Η Η Η
Η Η Η Η Η Η Η Η Η Η Ph-4-F Ph-4-Cl Ph~4~Br Ph+CF3 Ph-4-0CHF2 Ph-4-0CF3 Ph-4-0S02CH3 Ph-4-SCH3 Ph~4-S (0) CH3 Ph+S02CH3 Ph-4-CN Ph-3, 4-Cl2 L-46d L - 47e H H
Η Η Η Η Η
H H H H H H H H H 510 314918 200407073
3-0CF3 2-CH3 Ph-4-0CF3 F Cl H H 3-0CF3 2-CH3 Ph-4-0CF3 F Br H H 3-OCF3 2爲 Ph-4-0CF3 Cl Cl H H 3-OCFa 2-CH3 Ph-4-0CF3 Br Br H H 3-0CF3 2 - CH3 Ph-4-0CF3 CN CN H H 3-OCF3 2-CH3 Ph-4OCF2Br F F H H 3-OCF3 2 - CH3 Ph-卜 0CF2CHF2 F F H H 3-OCF3 2-CH3 Ph-4-0CF2CHFCFi » F F H H 3-OCF3 2 - CH3 Ph-4 - 0 (L - 45g) F F H H 3 - 0CF3 2-CH3 Ph-4-0 (L-45g) F Cl H H 3-OCF3 2-CH3 Ph-4-0 (L~45g) Cl Cl H H 3 - 0CF3 2-CH3 Ph-4-CN F F H H 3-OCF3 2-CH3 Ph-3,4-Cl2 F F H H 3-OCF3 2-CH3 L-46d F F H H 5-0CF3 2~CH3 Ph-4-0CF3 F F H H 3-0CF20-4 2-CH3 cf3 Cl Cl H Ph-4-Cl 3-0CF20~4 2-CH3 Ph+0CF3 F F H H 3-0CF2CF20-4 2 - CH3 cf3 Cl Cl H Ph-4-Cl 3-0CF2CF20-4 2-CH3 Ph-4-0CF3 F F H H 3-SCH3 2-CH3 cf3 H H H Ph-4-F 3-SCH3 2-CH3 cf3 H H H Ph-4-Cl 3-SCH3 2-CH3 cf3 H H H Ph-4-Br 3-SCHa 2-CH3 cf3 H H H Ph-4-0CF3 3-SCH3 2 - CH3 cf3 H H Cl Ph+Cl 3-SCH3 2-CH3 cf3 H H Br Ph+Cl 3-SCH3 2-CH3 cf3 Cl Cl H Ph-4-F 3-SCH3 2-CH3 cf3 Cl Cl H Ph+Cl 3-SCH3 2 - CH3 cf3 Cl Cl H Ph-4-Br 3-SCH3 2-CH3 cf3 Cl Cl H Ph-4-CF3 3-SCH3 2-CH3 cf3 Cl Cl H Ph-4-0CHF2 3-SCH3 2-CH3 cf3 Cl Cl H Ph~4~0CF 3 3-SCH3 2 - CH3 cf3 Cl Cl H Ph-4-S02CH 3-SCH3 2 - CH3 cf3 Cl Cl H Ph-4-CN 3-SCH3 2 - CH3 cf3 Cl Cl H Ph-3,4-Cl2 3-SCH3 2-CH3 cf3 Cl Cl H L-46d 3-SCHa 2 - CH3 Ph+F F F H H 3-SCHa 2 - CH3 Ph-4-F Cl Cl H H 51] 314918 200407073
3-SCH3 2-CH3 Ph-4-Cl F F H H 3-SCH3 2-CH3 Ph-4-Cl F Cl H H 3-SCH3 2«CH3 Ph-4-Cl Cl Cl H H 3-SCH3 2-CH3 Ph-4-Br F F H H 3-SCH3 2-CH3 Ph-4-Br Cl Cl H H 3-SCH3 2-CH3 Ph-4-CF3 F F H H 3-SCH3 2-CH3 Ph-4-CF3 Cl Cl H H 3-SCH3 2-CH3 Ph-4-0CHF2 F F H H 3-SCH3 2-CH3 Ph-4-0CHF2 Cl Cl H H 3-SCH3 2-CH3 Ph-4-0CF3 H H H H 3-SCH3 2-CH3 Ph-4-0CF3 F F H H 3-SCH3 2-CH3 Ph-4-0CF3 F Cl H H 3-SCH3 2-CH3 Ph+0CF3 F Br H H 3-SCH3 2-CH3 Ph-4-0CF3 Cl Cl H H 3~SCH3 2-CH3 Ph-4-0CF3 Br Br H H 3-SCH3 2-CH3 Ph+0CF3 CN CN H H 3-SCH3 2-CH3 Ph-4-0CF2Br F F H H 3-SCH3 2 - CH3 Ph-4-0CF2CHF2 F F H H 3-SCH3 2-CH3 Ph-4-0CF2CHFCF2 丨F F H H 3-SCH3 2-CH3 Ph - 4-0 (L - 45g) F F H H 3-SCH3 2-CH3 Ph - 4 -0 (L-45g) F Cl H H 3-SCHa 2-CH3 Ph - 4-0 (L-45g) Cl Cl H H 3~SCH3 2 - CH3 Ph-4-CN F F H H 3-SCH3 2 - CH3 Ph-3, 4-Cl2 F F H H 3-SCH3 2~CH3 L-46d F F H H 6-SCH3 2-CH3 Ph-4-0CF3 F F H H 3-S_3 2-CH3 cf3 H H H Ph+F 3-S (0) CH3 2-CH3 cf3 H H H Ph+Cl 3-S ⑼ CH3 2~CH3 cf3 H H H PH - Br 3-S (0) CH3 2-CH3 cf3 H H H Ph-4-0CF3 3-S (0) CH3 2-CH3 cf3 H H Cl Ph-4-Cl 3-S _3 2-CH3 cf3 H H Br Ph-4-Cl 3-S _3 2 - CH3 cf3 Cl Cl H Ph-4-F 3-S (0KH3 2 - CH3 cf3 Cl Cl H Ph-4-Cl 3-S(0)CH3 2-CH3 cf3 Cl Cl H Ph-4-Br 3-S (0) CH3 2 - CH3 cf3 Cl Cl H Ph-4-CF3 3-S (0) CH3 2-CH3 cf3 Cl Cl H Ph-4-OCHF 512 314918 200407073 3-S(0) CH3 2-CH3 cf3 Cl 3-S (0) CH3 2 - CH3 cf3 Cl 3-S (0) CH3 2 - CH3 cf3 Cl 3-S (0&gt; CH3 2 - CH3 cf3 Cl 3-S(0) CH3 2-CH3 Ph-4-F F 3-S(0)CH3 2-CH3 Ph-4-F Cl 3-S (0) CH3 2-CH3 Ph-4-C1 F 3-S(0) CH3 2-CH3 Ph-4-Cl F 3-S (0) CH3 2 - CH3 Ph+Cl Cl 3~S(0)CH3 2 - CH3 Ph-4-Br F 3~S(0)CH3 2 - CH3 Ph-4-Br Cl 3-S(0)CH3 2-CH3 Ph-4-CF3 F 3-S (0) CH3 2-CH3 Ph+CF3 Cl 3-S(0) CH3 2 - CH3 Ph~4-0CHF2 F 3-S(0) CH3 2-CH3 Ph-4-0CHF2 Cl 3-S(0) CH3 2-CH3 Ph-4-0CF3 H 3-S(0)CH3 2 - CH3 Ph-4-0CF3 F 3-S(0)CH3 2-CH3 Ph-4-0CF3 F 3~S(0) CH3 2-CH3 Ph+OCF3 F 3-S(0)CH3 2-CH3 Ph-4-OCFs Cl 3-S(0) CH3 2-CH3 Ph-4-0CF3 Br 3-S(0)CH3 2-CH3 Ph-4-OCFa CN 3-S (0) CH3 2-CH3 Ph-4-0CF2Br F 3-S (0) CH3 2-CH3 Ph-4-0CF2CHF2 F 3-S(0)CH3 2 - CH3 Ph-4~0CF2CHFCF3 F 3-S (0) CH3 2-CH3 Ph-4-0 (L-45g) F 3-S(0)CH3 2 - CH3 Ph-4-0 (L-45g) F 3-S ⑼ CH3 2-CH3 Ph-4-0 (L-45g) Cl 3-S(0) CH3 2-CH3 Ph-4-CN F 3-S(0) CH3 2-CH3 Ph-3, 4-Cl 2 F 3-S(0)CH3 2 - CH3 L-46d F 6-S02CH3 2 - CH3 Ph-4-0CF3 F 6-SPr-i 2 - CH3 ph-ocf3 F 6-S (O)Pr-i 2-CH3 Ph-4-0CF3 F 6-S02Pr-i 2 - CH3 Ph-4-OCFa F 3-SCHF2 2-CH3 cf3 Cl 3-SCHF2 2 - CH3 cf3 Cl
F Η H Cl Η H
Cl H Ph-4-0CF3
Cl H Ph+S02CH3
Cl H Ph-3,4-Cl2
Cl H L-46d
F Η H
Cl Η H
F Η H
Cl Η H
Cl Η H
Cl H Ph-4-F
Cl H Ph+Cl 513 314918 200407073 3-SCHF2 2 - CH3 cf3 Cl Cl H 3-SCHF2 2-CH3 cf3 Cl Cl H 3-SCHF2 2-CH3 cf3 Cl Cl H 3-SCHF2 2~CH3 cf3 Cl Cl H 3-SCHF2 2 - CH3 cf3 Cl Cl H 3~SCHF2 2 - CH3 cf3 Cl Cl H 3-SCHF2 2-CH3 cf3 Cl Cl H 3-SCHF2 2 - CH3 cf3 Cl Cl H 3-SCHF2 2-CH3 Ph-4-F F F H 3-SCHF2 2-CH3 Ph+F Cl Cl H 3-SCHF2 2 - CH3 Ph-4-Cl F F H 3-SCHF2 2-CH3 Ph-4-C1 F Cl H 3-SCHF2 2 - CH3 Ph-4-C1 Cl Cl H 3-SCHF2 2 - CH3 Ph-4-Br F F H 3-SCHF2 2 - CH3 Ph+Br Cl Cl H 3-SCHF2 2-CH3 Ph-4-CF3 F F H 3-SCHF2 2-CH3 Ph-4-CF3 Cl Cl H 3-SCHF2 2 - CH3 Ph-4-0CHF2 F F H 3-SCHF2 2-CH3 Ph-4-0CHF2 Cl Cl H 3-SCHF2 2-CH3 Ph~4~0CF3 H H H 3-SCHF2 2~CH3 Ph-4~0CF3 F F H 3~SCHF2 2-CH3 Ph-4-0CF3 F Cl H 3-SCHF2 2-CH3 Ph-4-0CF3 F Br H 3-SCHF2 2-CH3 Ph-4-0CF3 Cl Cl H 3-SCHF2 2-CH3 Ph-4-0CF3 Br Br H 3-SCHF2 2-CH3 Ph-4-0CF3 CN CN H 3-SCHF2 2-CH3 Ph-4-0CF2Br F F H 3-SCHF2 2-CH3 Ph-4-0CF2CHF2 F F H 3-SCHF2 2-CH3 Ph-4-0CF2CHFCF3 F F H 3-SCHF2 2-CH3 Ph-4-0 (L-45g) F F H 3~SCHF2 2-CH3 Ph-4 - 0(L-45g) F Cl H 3-SCHF2 2~CH3 Ph - 4-0 (L-45g) Cl Cl H 3-SCHF2 2-CH3 Ph-4-CN F F H 3-SCHF2 2-CH3 Ph - 3,4-Cl2 F F H 3-SCHF2 2-CH3 L - 46d F F H 3-S(0)CHF2 2 - CH3 cf3 Cl Cl H 3~S (0) CHF2 2 - CH3 cf3 Cl Cl H Ph-4_F Ph-4-Cl
Ph~4~Br Ph-4-CF3 Ph-4-0CHF2 Ph-4-0CF3 Ph+S02CH3 Ph+CN Ph-3,4-Cl2 L - 46d
514 314918 200407073
3-S (0)CHF2 2-CH3 cf3 Cl Cl H 3-S (0)CHF2 2-CH3 cf3 Cl Cl H 3-S (0) CHF2 2 - CH3 cf3 Cl Cl H 3-S (0) CHF2 2-CH3 cf3 Cl Cl H 3-S (0) CHF2 2 - CH3 cf3 Cl Cl H 3-S (0)CHF2 2 - CH3 cf3 Cl Cl H 3-S (0)CHF2 2~CH3 cf3 Cl Cl H 3-S(0)CHF2 2-CH3 cf3 Cl x\ H 3-S(0)CHF2 2 - CH3 Ph-4-F F F H 3-S (0) CHF2 2 - CH3 Ph-4-F Cl Cl H 3-S (0) CHF2 2-CH3 Ph+Cl F F H 3-S (0) CHF2 2-CH3 Ph+Cl F Cl H 3-S (0) CHF2 2-CH3 Ph+Cl Cl Cl H 3-S ⑼ CHF2 2 - CH3 Ph-4-Br F F H 3-S (0) CHF2 2-CH3 Ph-4-Br Cl Cl H 3-S (0) CHF2 2-CH3 Ph+CF3 F F H 3-S(0) CHF2 2-CH3 Ph-4-CF3 Cl Cl H 3-S(0) CHF2 2-CH3 Ph-4-0CHF2 F F H 3-S (0) CHF2 2-CH3 Ph-4-0CHF2 Cl Cl H 3-S (0) CHF2 2 - CH3 Ph-4-0CF3 H H H 3-S(0) CHF2 2-CH3 Ph-4-0CF3 F F H 3-S (0) CHF2 2 - CH3 Ph-4-0CF3 F Cl H 3-S (0) CHF2 2-CH3 Ph-4~0CF3 F Br H 3-S (0) CHF2 2-CH3 Ph-4-0CF3 Cl Cl H 3-S (0) CHF2 2-CH3 Ph-4-0CF3 Br Br H 3-S (0) CHF2 2-CH3 Ph-4-0CF3 CN CN H 3-S (0) CHF2 2-CH3 Ph-4-0CF2Br F F H 3-S (0) CHF2 2-CH3 Ph-4-0CF2CHF2 F F H 3-S (0) CHF2 2-CH3 Ph-4-0CF2CHFCF3 F F H 3-S ⑼ CHF2 2-CH3 Ph-4-0(L-45g) F F H 3-S(0) CHF2 2-CH3 Ph-4-0 (L-45g) F Cl H 3-S (0)CHF2 2 - CH3 Ph - 4-〇(L-45g) Cl Cl H 3-S(0) CHF2 2-CH3 Ph-4-CN F F H 3-S (0) CHF2 2-CH3 Ph-3, 4-Cl2 F F H 3-S (0) CHF2 2 - CH3 L - 46d F F H 3-S02CHF2 2-CH3 cf3 Cl Cl H 3-S02CHF2 2-CH3 cf3 Cl Cl H
Ph-4-Br
Ph+CF3
Ph-4-0CHF2
Ph~4**0CF 3
Ph-4-S02CH3
Ph-4-CN
Ph-3, 4-Cl2 L-46d
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
Ph-4-F Ph-4-Cl 515 314918 200407073 3-S02CHF2 2-CH3 cf3 Cl 3-S02CHF2 2-CH3 cf3 Cl 3-S02CHF2 2 - CH3 cf3 Cl 3-S02CHF2 2-CHa cf3 Cl 3~S02CHF2 2-CH3 cf3 Cl 3-S02CHF2 2-CH3 cf3 Cl 3-S02CHF2 2 - CH3 cf3 Cl 3-S02CHF2 2-CH3 cf3 Cl 3-S02CHF2 2-CH3 Ph-4-F F 3-S02CHF2 2-CH3 Ph-4~F Cl 3-S02CHF2 2-CH3 Ph+Cl F 3-S02CHF2 2 - CH3 Ph-4-Cl F 3-S02CHF2 2-CH3 Ph-4-C1 Cl 3-S02CHF2 2-CH3 Ph_4-Br F 3-S02CHF2 2 - CH3 Ph+Br Cl 3-S02CHF2 2~CH3 Ph-4-CF3 F 3-S02CHF2 2 - CH3 Ph-4-CF3 Cl 3-S02CHF2 2-CH3 Ph-4-0CHF2 F 3-S02CHF2 2 - CH3 Ph+0CHF2 Cl 3-S02CHF2 2 - CH3 Ph+0CF3 H 3-S02CHF2 2~CH3 Ph-4-0CF3 F 3-S02CHF2 2 - CH3 Ph+0CF3 F 3-S02CHF2 2-CH3 Ph-4-0CF3 F 3-S02CHF2 2 - CH3 Ph-4-0CF3 Cl 3-S02CHF2 2-CH3 Ph-4-0CF3 Br 3-S02CHF2 2-CH3 Ph-4-0CF3 CN 3-S02CHF2 2 - CH3 Ph-4-0CF2Br F 3-S02CHF2 2-CH3 Ph-4-0CF2CHF2 F 3-S02CHF2 2-CH3 Ph-4-0CF2CHFCF3 F 3-S02CHF2 2-CH3 Pb - 4 -0 (L-45g) F 3-S02CHF2 2 - CH3 Ph~4~0 (L-45g) F 3-S02CHF2 2-CH3 Ph - 4 -0 (L-45g) Cl 3-S02CHF2 2-CH3 Ph-4-CN F 3-S02CHF2 2-CH3 Ph-3,4-Cl2 F 3~S02CHF2 2 - CH3 L-46d F 3-SCF3 2 - CH3 cf3 Cl 3-SCF3 2-CH3 cf3 Cl
Cl Η Ph-4-Br
Cl H Ph-4-CF3
Cl H Ph-4-0CHF2
Cl H Ph-4-0CF3
Cl H Ph+S02CH3
Cl H Ph-4-CN
Cl H Ph-3,4-Cl2
Cl H L-46d
Cl H Ph-4-F
Cl H Ph+Cl 516 314918 200407073 3-SCF3 3-SCFa 3-SCF3 3-SCFa 3-SCF3 3-SCFa 3-SCFa 3-SCF3 3-SCF3 3-SCFa 3-SCF3 3~SCF3 3-SCF3 3-SCFa 3-SCF3 3-SCFa 3 - SCF3 3-SCF3 3-SCF3 3-SCF3 3-SCFa 3-SCFa 3-SCFa 3-SCFa 3-SCFa 3-SCF3 3-SCF3 3-SCF3 3-SCF3 3-SCF3 3-SCFa 3-SCF3 3-SCF3 3-SCFa 3-SCFa 3-S (0) CF3 3-S(0)CF3 2-CH3 cf3 Cl Cl H Ph-4-Br 2-CH3 cf3 Cl Cl H Ph-4-CF3 2 - CH3 cf3 Cl Cl H Ph~4-0CHF2 2 - CH3 cf3 Cl Cl H Ph-4-OCFa 2-CH3 cf3 Cl Cl H Ph-4-S02CH 2 - CH3 cf3 Cl Cl H Ph-4-CN 2-CH3 cf3 C! Cl H Ph-3, 4-Cl2 2-CH3 cf3 Cl Cl H L - 46d 2-CH3 Ph+F F F H H 2-CH3 Ph-4-F Cl Cl H H 2 - CH3 Ph-4-Cl F F H H 2-CH3 Ph-4-Cl F Cl H H 2-CH3 Ph-4-Cl Cl Cl H H 2-CH3 Ph-4-Br F F H H 2-CH3 Ph+Br Cl Cl H H 2-CH3 Ph-4-CF3 F F H H 2-CH3 Ph-4~CF3 Cl Cl H H 2 - CH3 Ph+0CHF2 F F H H 2-CH3 Ph-4-0CHF2 Cl Cl H H 2-CH3 Ph-4-0CF3 H H H H 2-CH3 Ph-4-0CF3 F F H H 2-CH3 Ph-4-OCFs F Cl H H 2 - CH3 Ph-4-0CF3 F Br H H 2 - CH3 Ph-4-0CF3 Cl Cl H H 2-CH3 Ph-4-0CF3 Br Br H H 2-CH3 Ph-4-0CF3 CN CN H H 2-CH3 Ph-4-0CF2Br F F H H 2-CH3 Ph-4-0CF2CHF2 F F H H 2 - CH3 Ph-4-0CF2CHFCF3 F F H H 2-CH3 Ph-4 - 0 (L-45g&gt; F F H H 2-CH3 Ph-4-0(L-45g) F Cl H H 2-CH3 Ph-4 - 0 (L-45g) Cl Cl H H 2 - CH3 Ph+CN F F H H 2 - CH3 Ph-3, 4-Cl2 F F H H 2 - CH3 卜46d F F H H 2-CH3 cf3 Cl Cl H Ph-4-F 2 - CH3 cf3 Cl Cl H Ph+Cl
517 314918 200407073 3-S(0) CF3 2 - CH3 cf3 Cl 3-S{〇) CF3 2-CH3 cf3 Cl 3-S (0) CF3 2-CH3 cf3 Cl 3-S(0)CF3 2 - CH3 cf3 Cl 3-S ⑼ CF3 2-CH3 cf3 Cl 3-S ⑼ CF3 2 - CH3 cf3 Cl 3-S(0)CF3 2 - CH3 cf3 Cl 3-S(0)CF3 2 - CH3 cf3 Cl 3-S (0) CF3 2-CH3 Ph-4-F F 3-S(0) CF3 2-CH3 Ph-4-F Cl 3-S (0) CF3 2-CH3 Ph+Cl F 3-S ⑼ CF3 2~CH3 Ph_4-Cl F 3-S(0KF3 2-CH3 Ph-4-Cl Cl 3~S (0) CF3 2-CH3 Ph+Br F 3-S (0) CF3 2-CH3 Pli - 4-Br Cl 3-S (0)CF3 2-CH3 Ph-4-CF3 F 3-S (0)CF3 2-CH3 Ph-4-CF3 Cl 3-S(0&gt;CF3 2-CH3 Ph-4-0CHF2 F 3-S (0)CF3 2~CH3 Ph-4-0CHF2 Cl 3-S(0&gt;CF3 2-CH3 Ph-4-0CF3 H 3-S (0) CF3 2-CH3 Ph-4-0CF3 F 3~S (0)CF3 2-CH3 Ph-4-0CF3 F 3-S (0)CF3 2~CH3 Ph-4-0CF3 F 3-S(0KF3 2-CH3 Ph-4-0CF3 Cl 3-S (0KF3 2-CH3 Ph-4-0CF3 Br 3-S(0) CF3 2 - CH3 Ph~4-0CF3 CN 3-S (0) CF3 2-CH3 Ph-4-0CF2Br F 3-S (0) CF3 2 - CH3 Ph-4-0CF2CHF2 F 3-S(0)CF3 2-CH3 Ph-4-0CF2CHFCF3 F 3-S(0)CF3 2-CH3 Ph-4-0(L-45g) F 3~S (0) CF3 2 - CH3 Ph - 4 -0 (L - 45g&gt; F 3-S(0KF3 2-CH3 Ph - 4 一0(L - 45g) Cl 3-S(0) CF3 2-CH3 Ph-4-CN F 3-S(0) CF3 2-CH3 Ph-3,4-Cl2 F 3-S(0) CF3 2 - CH3 L - 46d F 6-S (0)CF3 2 - CH3 cf3 Cl 3-S0〇CF 3 2 - CH3 cf3 Cl
Cl Η Ph-4-Br
Cl H Ph~4-CF3
Cl H Ph~4-0CHF2
Cl H Ph-4-0CF3
Cl H Ph-4-S02CH3
Cl H Ph-4-CN
Cl Η P卜 3,4-Cl2
Cl H L-46d
Cl Η H
Br Η H
Cl Η Η φ
Br Η H
CN Η H
F Η H
F Η H
F Η H
F Η H
Cl Η H
Cl Η H
F Η H
F Η H
F Η H
Cl H Ph-4-Cl
Cl H Ph-4-F 518 314918 200407073
3-S02CF 3 2 - CH3 cf3 Cl Cl 3 - SO 2 CF 3 2 - CH3 cf3 Cl Cl 3~S〇2CF 3 2 - CH3 cf3 Cl Cl 3~S02CF 3 2 - CH3 cf3 Cl Cl 3 - SO 2 CF 3 2 - CH3 cf3 Cl Cl 3 - SO 2 CF 3 2-CH3 cf3 Cl Cl 3-SO2CF 3 2-CH3 cf3 Cl Cl 3*-S02CF3 2 - CH3 cf3 Cl Cl 3-S02CF3 2~CH3 cf3 Cl Cl 3-SO2CF 3 2 - CH3 Ph-4-F F F 3~S02CF 3 2-CH3 Ph-4-F Cl Cl 3-S02CF3 2 - CH3 Ph-4-Cl F F 3-SO2CF3 2 - CH3 Ph-4-Cl F Cl 3 - SO 2 CF 3 2-CH3 Ph-4-Cl Cl Cl 3~S02CF 3 2 - CH3 Ph-4-Br F F 3-SO2CF 3 2-CH3 Ph-4-Br Cl Cl 3-S02CF3 2-CH3 Ph-4-CF3 F F 3-SO2CF3 2-CH3 Ph-4-CF3 Cl Cl 3-S02CF3 2~CH3 Ph-4-0CHF2 F F 3_S〇2CF 3 2 - CH3 Ph-4-0CHF2 Cl Cl 3-SO2CF3 2-CH3 Ph-4-0CF3 H H 3*S02CF 3 2-CH3 Ph-4-0CF3 F F 3~S02CF3 2 - CH3 Ph-4-0CF3 F Cl 3-S02CF3 2 - CH3 Ph-4-0CF3 F Br 3~S02CF 3 2-CH3 Ph-4~0CF3 Cl Cl 3~S02CF 3 2-CH3 Ph-4-0CF3 Br Br 3 - SO 2 CF 3 2-CH3 Ph-4-0CF3 CN CN 3 - SO 2 CF 3 2-CH3 Ph-4-0CF2Br F F 3-SO2CF3 2 - CH3 Pb-4-0CF2CHF2 F F 3-SO2CF3 2 - CH3 Ph-4-0CF2CHFCF3 F F 3-S02CF 3 2-CH3 Ph - 4-0 (L - 45g) F F 3-SO2CF3 2-CH3 Ph-4O a-45g) F Cl 3~S02CF 3 2-CH3 Ph-4-0(L-45g&gt; Cl Cl 3 - SO 2 CF 3 2 - CH3 Ph-4-CN F F 3-*S02CF 3 2 - CH3 Ph-3, 4-Cl2 F F 3~S02CF 3 2-CH3 L - 46d F F 3-SCH2CF3 2 - CH3 Ph-4-0CF3 F F Η Η Η Η Η Η Η Η Η Η Η
Ph+Cl Ph-4-Br Ph-4-CF3 Ph-4-0CHF2 Ph-4-0CF3 Ph-4-S02CH3 Ph-4-CN Ph-3, 4-Cl 2 L」46d H H H H H H H H H H H H H H H H H
Η Η Η Η Η Η Η Η Η
H H H H H H H H H 519 314918 200407073
6-SCH2CF3 2 - CH3 Ph~4-0CF3 F 3-S (0) CH2CF3 2-CH3 Ph-4-0CF3 F 6-S(0) CH2CF3 2-CH3 Ph-4-0CF3 F 3-S02CH2CF3 2-CH3 Ph-4_0CF3 F 3-n+SCF3 2-CH3 Ph-4-0CF3 F 6-NO 2 2-CH3 cf3 Cl 6-N0 2 2 - CH3 cf3 Cl 6-N0 2 2-CH3 cf3 Cl 6-N0 2 2-CH3 cf3 Cl 6-N02 2-CH3 cf3 Cl 6爲 2 - CH3 cf3 Cl 6 - N02 2爲 cf3 Cl 6 - N02 2 - CH3 cf3 Cl 6 - N02 2-CH3 Ph-4-F F 6-N02 2-CH3 Ph+Cl F 6，N02 2-CH3 Ph-4-Br F 6-N02 2-CH3 Ph~4-CF 3 F 6-N02 2-CH3 Ph-4~0CHF2 F 6-N02 2 - CH3 Ph-4-0CF3 F 6-N0 2 2-CH3 Ph-4-0CF3 Cl 6-N0 2 2 - CH3 Ph-4—0 (L - 45g) F 3-CN 2-CH3 Ph-4-0CF3 F C(0) NHPr-i 2-CH3 Ph-4-0CF3 F 3-C=CH 2-CH3 Ph-4-0CF3 F 6 - feCH 2~CH3 Ph-4-0CF3 F 3-C=CSi (CH3) a 2-CH3 Ph-4-0CF3 F 6-Ph 2-CH3 Ph-4-0CF3 F 3-CH=CH~CH=CH-4 2-CH3 Ph+0CF3 F 3-Si (CH3) a 2 - CH3 Ph-4-0CF3 F
Η Η Η Η Η
Ph-4~F
Ph-4-Cl
Ph~4~Br
Ph-4-CF3
Ph-4-0CHF2
Ph-4-0CF3
Ph-4-S02CH3 L - 46d
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H
H 520 3]49】8 200407073 第6表 ΟΥ ΟΥ
521 314918 200407073
[5】· 12
Y
【5]-17 , [5] -18
[5]-19 , [5]· 20 522 3149J8 200407073
[5]-21 或 [5]-22 Y R4 R5 F cf3 Ph-4-F F cf3 Ph-4-Cl F cf3 Ph+Br F cf3 Ph+CF3 F cf3 Ph-4-0CHF2 F cf3 Ph-4-0CF3 F cf3 Ph-4-0S02CH3 F cf3 Ph+SCH3 F cf3 Ph-4_S (0) CH3 F cf3 Ph-4-S02CH3 F cf3 Ph-4-CN F cf3 L - 46d F Ph-4-Cl ch3 F Ph+0CF3 ch3 Cl ch3 Ph+Cl Cl ch3 Ph-4-Br · Cl ch3 Ph-4-0CF3 Cl ch3 Ph-4-S02CH3 Cl Et PH-Cl Cl n-Pr Ph+S02CH3 Cl i-Pr Ph-4-Cl Cl chf2 Ph-4-F Cl chf2 Pb+Cl Cl chf2 Ph+Br Cl chf2 Ph-4-0CF3 Cl chf2 Ph-4-S02CH3 Cl cf3 Ph-4-F Cl cf3 Pb+Cl
523 314918 200407073
Cl cf3 Cl cf3 Cl cf3 Cl cf3 Cl ‘ cf3 C! cf3 Cl cf3 Cl cf3 Cl cf3 Cl cf3 Cl cf3 Cl cf3 Cl cf3 Cl cf3 Cl cf2ci Cl cf2cf3 Cl Ph-4-F Cl Ph-4-Cl Cl Ph-4-Br Cl Ph-4-CF3 Cl Ph-4-0CHF2 Cl Ph-4-0CF3 Cl Ph-4-0CF2Br Cl Ph-4-0CF2CHFCF3 Cl Ph-4-0CF2CHF0CF Cl Ph-4-0CF2CHF0CF； Cl Ph-3, 4-F2 Cl Ph-3-F-4-C1 Cl Ph-3, 4-Cl2 Br cf3 Br cf3 Br cf3 Br cf3 Br cf3 Br cf3 Br cf3 Br cf3
Ph-4-Br
Ph-4-CF3
Ph-4-0CHF2
Ph-4-0CF3
Ph+0S02CH3
Ph-4~SCH3
Ph-4-S(0) CH3
Ph-4-S02CH3
Ph-4-N02
Ph-4-CN
Ph+C_H2
Pli-4-C ⑸ NH2
Ph-3,4 - Cl2 L-46d
Ph-4-S02CH3
Ph+Cl CH3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 ch3 cf3 ch3 ch3 ch3 ch3
Ph~4~F
Ph-4-Cl
Ph-4-Br
Ph-4-CF3
Ph-4-0CHF2
Ph-4-0CF3
Ph-4-0S02CH3
Ph+SCH3
524 314918 200407073
Br cf3 Ph-4-S(0) CH3 Br cf3 Ph+S02CH3 Br cf3 Ph+N02 Br cf3 Ph-4-CN Br cf3 Ph-4-C (0)NH2 Br cf3 Ph - 4-C ⑸ NH2 Br cf3 L-46d Br Ph-4-F ch3 Br Ph+Cl ch3 Br Ph-4~Br ch3 Br Ph-4-CF3 ch3 Br Ph-4~0CHF2 ch3 Br Ph-4-0CF3 * ch3 Br Ph+0CF2Br ch3 Br Ph-4-0CF2CHFCF3 ch3 Br Ph-4-0CF2CHF0CF2CF2CF3 ch3 I cf3 Ph-4-Cl I cf3 Ph-4-Br I cf3 Ph-4-0CF3 I cf3 Ph-4-S02CH3 I Ph+Cl ch3 I Ph-4-0CF3 ch3 ch3 ch3 Ph-4-F ch3 ch3 Ph-4-Cl ch3 ch3 Ph+Br ch3 ch3 Ph+I ch3 ch3 Ph-4-CF3 ch3 ch3 Ph-4-0CHF2 ch3 ch3 Ph-4-0CF3 ch3 ch3 Ph-4-0CF2Br ch3 ch3 Ph-4-0CF2CHF2 ch3 ch3 Ph-4-0CF2CHFCl ch3 ch3 Ph-4-0CF2CHFCF3 ch3 ch3 Ph-4-0CF2CHF0CF3 ch3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 ch3 ch3 Ph-4-0S0?CH3 ch3 ch3 Ph-4-0 a-45g)
525 314918 200407073 ch3 ch3 Ph+SCH3 ch3 ch3 Ph+S ⑼ CH3 ch3 ch3 Ph+S02CH3 ch3 ch3 Ph-4-SEt ch3 ch3 Ph-4-S02Et ch3 ch3 Ph-4-SPr-n ch3 ch3 Ph-4-S02Pr-n ch3 ch3 Ph-4-SPr-i ch3 ch3 Ph+S02Pr-i ch3 ch3 Ph-4-N02 ch3 ch3 Ph+CN ch3 ch3 Ph-4-C (0)NH2 ch3 ch3 Ph - 4-C ⑸ NH2 ch3 ch3 Ph-3, 4-F2 ch3 ch3 Ph-3~F-4~C1 ch3 ch3 Ph-3, 4-Cl2 ch3 ch3 L-45d ch3 ch3 L - 45e ch3 ch3 L - 45g ch3 ch3 L-45m ch3 ch3 L-46d ch3 ch3 Lr46e ch3 ch3 L-46g ch3 ch3 L - 46j ch3 ch3 L-46k ch3 ch3 L-46m ch3 ch3 L-46n ch3 ch3 L - 46r ch3 ch3 L-47a ch3 ch3 L-47e ch3 Et Ph~4~F ch3 Et Ph-4-Cl ch3 Et Ph+Br ch3 Et Ph-4-CF3 ch3 Et Ph~4-0CHF2 ch3 Et Ph-4-0CF3 ch3 Et Ph-4-0S02CH3
526 314918 200407073 ch3 Et Ph-4-SCH3 ch3 Et Ph-4-S02CH3 ch3 Et Ph+N02 ch3 Et Ph+CN ch3 Et Ph-3, 4-Cl2 ch3 Et L_46d ch3 Et L - 47e ch3 n-Pr Ph-4-F ch3 n-Pr Ph_4-Cl ch3 n-Pr Ph-4_Br ch3 n-Pr Pli - 4-0CF3 ch3 n-Pr Ph-4-S02CH3 ch3 i-Pr Ph-4-F ch3 i - Pr Ph+Cl ch3 i - Pr Ph-4-Br ch3 i - Pr Ph-4-0CF3 ch3 i - Pr Ph-4-S02CH3 ch3 c-Pr Ph+F ch3 c-Pr Ph-4-Cl ch3 c-Pr Ph-4-Br ch3 c-Pr Ph-4-0CF3 ch3 c - Pr Ph+S02CH3 ch3 T-l ch3 ch3 T-2 ch3 ch3 n-Bu Ph+Cl ch3 n-Bu Ph+S02CH3 ch3 T-3 ch3 ch3 T-4 ch3 ch3 T-5 ch3 ch3 c - Pen ch3 ch3 chf2 Ph-4-F ch3 chf2 Ph-4-Cl ch3 chf2 Ph-4-Br ch3 chf2 Ph-4-1 ch3 chf2 Ph-4-CF3 ch3 chf2 Ph-4-0CHF2 ch3 CHF〇 Ph-4-0CF3 314918 200407073 ch3 chf2 Ph-4-0CF2Br ch3 chf2 Ph-4-0CF2CHF2 ch3 chf2 Ph-4-0CF2CHFCl ch3 chf2 Ph-4-0CF2CHFCF3 ch3 chf2 Ph-4-0CF2CHF0CF3 ch3 chf2 Ph-4-0CF2CHF0CF2CF2CF ch3 chf2 Ph-4-0S02CH3 ch3 chf2 Ph~4~0 (L~45g) ch3 chf2 Ph-4-SCH3 ch3 chf2 Ph+S (0) CH3 ch3 chf2 Ph-4-S02CH3 ch3 chf2 Ph-4-N02 ch3 chf2 Ph-4-CN ch3 chf2 Ph-4-C (0)NH2 ch3 chf2 Ph - 4-C ⑸ NH2 ch3 chf2 Ph-3, 4-F2 ch3 chf2 Ph-3~F-4~CI ch3 chf2 Ph-3,4-Cl2 ch3 chf2 L-45d ch3 chf2 L-45e ch3 chf2 L-45g ch3 chf2 L - 45m ch3 chf2 L-46d ch3 chf2 L - 46e ch3 chf2 L-46g ch3 chf2 L-46j ch3 chf2 L - 46k ch3 chf2 L-46m ch3 chf2 L-46n ch3 chf2 L - 46r ch3 chf2 L - 47a ch3 chf2 L - 47e ch3 cf3 Cl ch3 cf3 Br ch3 cf3 ch3 ch3 cf3 Et ch3 cf3 n-Pr
528 314918 200407073 ch3 cf3 i-Pr ch3 cf3 . c-Pr ch3 cf3 c-Bu ch3 cf3 c - Pen ch3 cf3 c-Hex ch3 cf3 chf2 ch3 cf3 cf3 ch3 cf3 cf2ci ch3 cf3 cfci2 ch3 cf3 cf2chf2 ch3 cf3 cf2cf3 ch3 cf3 T-1 ch3 cf3 T-2 ch3 cf3 T-3 ch3 cf3 T-4 ch3 cf3 T-5 ch3 cf3 CH20CH3 ch3 cf3 ch2sch3 ch3 cf3 ch2so2ch ch3 cf3 ch2scf3 ch3 cf3 ch2so2cf ch3 cf3 M- 4a ch3 cf3 M - 5a ch3 cf3 och3 ch3 cf3 OEt ch3 cf3 OPr-n ch3 cf3 OPr-i ch3 cf3 och2cf3 ch3 cf3 OCH(CF3)： ch3 cf3 sch3 ch3 cf3 so2ch3 ch3 cf3 SEt ch3 cf3 S02Et ch3 cf3 SPr-n ch3 cf3 S02Pr-n ch3 cf3 SPr - i ch3 cf3 S02Pr-i
529 314918 200407073 ch3 cf3 sch2cf3 ch3 cf3 N(CH3)2 ch3 cf3 T -16 ch3 cf3 T-17 ch3 cf3 T -18 ch3 cf3 T -19 ch3 cf3 T - 20 ch3 cf3 T-21 ch3 cf3 C(CH3)=N0CH3 ch3 cf3 T-22 ch3 cf3 T - 23 ch3 cf3 T-24 ch3 cf3 Ph ch3 cf3 Ph-4-F ch3 cf3 Ph+Cl ch3 cf3 Ph-4-Br ch3 cf3 Ph-4-1 ch3 cf3 Ph-4-CF3 ch3 cf3 Ph-4-C (CF3) 2〇H ch3 cf3 Ph~4-CH2SCH3 ch3 cf3 Ph-4-CH2S(0) CH3 ch3 cf3 Ph-4-CH2S02CH3 ch3 cf3 PH - CH2SCF3 ch3 cf3 Ph - 4-CH2S(0)CF3 ch3 cf3 Ph-4-CH2S02CF3 ch3 cf3 Ph~4-0CHF2 ch3 cf3 Ph-4-0CF3 ch3 cf3 Ph-4-0CF2Br ch3 cf3 Ph-4-0CF2CHF2 ch3 cf3 Ph+0CF2CHFC1 ch3 cf3 Ph-4-0CF2CHFBr ch3 cf3 Ph-4-0CF2CF2Br ch3 cf3 Ph-4-0CF2CFCl2 ch3 cf3 Ph-4-0CF2CC13 ch3 cf3 Ph-4-0CH2CF2CHF2 ch3 cf3 Ph-4-0CF2CHFCF3 ch3 cf3 Ph-4-0CH(CF3) 2
530 314918 200407073 ch3 cf3 Ph-4-0CF2CFBrCF3 ch3 cf3 Ph-4~0CF2CHF0CF3 ch3 cf3 Ph-4-0CF2CHF0CF2CF2CF3 ch3 cf3 Ph+0S02CH3 ch3 cf3 Ph-4-0S02CF3 ch3 cf3 Ph - 4 一0(L - 45g&gt; ch3 cf3 Ph-4-0 (L-451) ch3 cf3 Ph-4-SCH3 ch3 cf3 Ph - 4-S (0) CH3 ch3 cf3 Ph-4-S02CH3 ch3 cf3 Ph-4-SEt ch3 cf3 Ph-4-S (0) Et ch3 cf3 Ph+S02Et ch3 cf3 Ph-4-SPr-n ch3 · cf3 Ph-4-S ⑼ Pr-n ch3 cf3 Ph-4~S02Pr-n ch3 cf3 PH - SPr-i ch3 cf3 Ph-4-S (0) Pr-i ch3 cf3 Ph-4-S02Pr-i ch3 cf3 Ph-4-SCHF2 ch3 cf3 Ph-4-S (0) CHF2 ch3 cf3 Ph-4-S02CHF2 ch3 cf3 Ph-4-SCF3 ch3 cf3 Ph-4-S (0) CF3 ch3 cf3 Ph-4-S02CF3 ch3 cf3 Ph~4-SCF2C1 ch3 cf3 Ph-4-S ⑼ CF2C1 ch3 cf3 Ph-4-S02CF2Cl ch3 cf3 Ph-4-SCF2Br ch3 cf3 Ph-4-S ⑼ CF2Br ch3 cf3 Ph-4-S02CF2Br ch3 cf3 Ph-4-N02 ch3 cf3 Ph-4-CN ch3 cf3 Ph-4-C (0) NH2 ch3 cf3 Ph-4-C ⑸ NH2 ch3 cf3 Ph - 3,4-F2 ch3 cf3 Ph-3-F&gt;4-Cl
53] 314918 200407073 CH3 cf3 Ph-3~F~4~CF ch3 cf3 Ph-3t 4-Cl2 ch3 cf3 2-Naph ch3 cf3 L-lb ch3 cf3 L - 1c ch3 cf3 L-ld ch3 cf3 L-le ch3 cf3 L-lf ch3 cf3 L-lg ch3 cf3 L-li ch3 cf3 L - 2b ch3 cf3 L - 3b ch3 cf3 L - 3c ch3 cf3 L-3d ch3 cf3 L - 3e ch3 cf3 L-3f ch3 cf3 L - 3h ch3 cf3 L-3i ch3 cf3 L - 3j ch3 cf3 L - 3k ch3 cf3 L-31 ch3 cf3 L - 3m ch3 cf3 L-3n ch3 cf3 L-3o ch3 cf3 L_4b ch3 cf3 L - 4c ch3 cf3 L_4d ch3 cf3 L - 4e ch3 cf3 L-lOb ch3 cf3 L - 10c ch3 cf3 L- lOd ch3 cf3 L-14b ch3 cf3 L-14c ch3 cf3 L - 14d ch3 cf3 L - 14i ch3 cf3 L_14g ch3 cf3 L - 14h 200407073 ch3 cf3 L - 17a ch3 cf3 L-21b ch3 cf3 L-21c ch3 cf3 L - 21e ch3 cf3 卜22b ch3 cf3 L-22c ch3 cf3 L-22d ch3 cf3 L-23b ch3 cf3 L - 23c ch3 cf3 L-23e ch3 cf3 L~23f ch3 cf3 L-23g ch3 cf3 L-23h ch3 cf3 L - 24b ch3 cf3 L - 24c ch3 cf3 L - 24d ch3 cf3 L - 24e ch3 cf3 L-31a ch3 cf3 L-31b ch3 cf3 L~31c ch3 cf3 L - 36a ch3 cf3 L-36c ch3 cf3 L-36d ch3 cf3 L - 45c ch3 cf3 L_45d ch3 cf3 L-45e ch3 cf3 卜45i ch3 cf3 L-45g ch3 cf3 L-45h ch3 cf3 L-45m ch3 cf3 L-46d ch3 cf3 L-46e ch3 cf3 L - 46f ch3 cf3 L-46g ch3 cf3 L-46j ch3 cf3 L-偷 ch3 cf3 L-46ni 200407073 ch3 cf3 L-46n ch3 cf3 L - 46o ch3 cf3 L-46P ch3 cf3 L~46q ch3 cf3 L-46r ch3 cf3 L - 47a ch3 cf3 L-47e ch3 cf3 L - 48b ch3 cf3 L-50b ch3 cf3 L - 50c ch3 cf3 L，50d ch3 cf3 L-50e ch3 cf3 L - 50i ch3 cf3 L-51b ch3 cf3 L-51c ch3 cf2ci Ph+F ch3 cf2ci Ph-4-Cl ch3 cf2ci Ph+Br ch3 cf2ci Ph+CF3 ch3 cf2ci Ph-4-0CHF2 ch3 cf2ci Ph-4-0CF3 ch3 cf2ci Ph-4-S02CH ch3 cf2ci L-46d ch3 CF2Br Ph-4-Cl ch3 CF2Br Ph-4-S02CH ch3 cf2cf3 Ph-4-F ch3 cf2cf3 Ph+Cl ch3 cf2cf3 Ph+Br ch3 cf2cf3 Ph-4，CF3 ch3 cf2cf3 Ph-4-0CHF2 ch3 cf2cf3 Ph~4~0CF3 ch3 cf2cf3 Ph+S02CH ch3 cf2cf3 L-46d ch3 cf2cf2cf3 Ph-4-Cl ch3 cf2cf2cf3 Ph-4~S02CH ch3 cf(cf3)2 Ph-4-Cl ch3 cf(cf3)2 Ph-4-S02CH；
534 314918 200407073 ch3 cf2cf2cf2cf3 Ph-4-Cl ch3 cf2cf2cf2cf3 Ph-4-S02CH3 ch3 ch2och3 Ph-4-Cl ch3 ch2och3 Ph~4~S02CH3 ch3 ch2ch2och3 Ph_4-Cl ch3 ch2ch2och3 Ph+S02CH3 ch3 ch2och2cf3 Cl ch3 ch2och2cf3 ch3 ch3 ch2och2cf3 och3 ch3 ch2och2cf3 sch3 ch3 ch2och2cf3 N(CH3)2 CH3 ch2och2cf3 Ph-4-Cl ch3 ch2och2cf3 Ph+S02CH3 ch3 ch2och2cf2cf3 Cl ch3 ch2och2cf2cf3 ch3 ch3 ch2och2cf2cf3 och3 ch3 ch2och2cf2cf3 sch3 ch3 ch2och2cf2cf3 N(CH3)2 ch3 ch2och2cf2cf3 Ph-4-Cl ch3 ch2och2cf2cf3 Ph-4-S02CH3 ch3 ch2sch3 Ph-4-Cl ch3 ch2sch3 Ph-4-S02CH3 ch3 ch2scf3 Cl ch3 ch2scf3 ch3 ch3 ch2scf3 och3 ch3 ch2scf3 sch3 ch3 ch2scf3 N(CH3)2 ch3 ch2scf3 Ph+Cl ch3 ch2scf3 Ph+S02CH3 ch3 ch2ch2scf3 Cl ch3 ch2ch2scf3 ch3 ch3 ch2ch2scf3 och3 ch3 ch2ch2scf3 sch3 ch3 ch2ch2scf3 N(CH3)2 ch3 ch2ch2scf3 Ph+Cl ch3 ch2ch2scf3 Ph-4~S02CH3 ch3 T - 22 ch3 200407073 ch3 T-23 ch3 ch3 T-24 ch3 ch3 Ph ch3 ch3 Ph Ph-4-C1 ch3 Ph Ph-4-S02CH3 ch3 Ph+F ch3 ch3 Ph-4-Cl ch3 ch3 Ph-4-Cl Ph-4-Cl ch3 Ph-4-Cl Ph-4-S02CH3 ch3 Ph-4-Br ch3 ch3 Ph+I ch3 ch3 Ph+CF3 ch3 ch3 Ph-4-0CHF2 ch3 ch3 Ph-4-0CF3 Cl ch3 Ph+0CF3 ch3 ch3 Ph-4-0CF3 och3 ch3 Ph-4-0CF3 sch3 ch3 Ph-4-0CF3 N(CH3)2 ch3 Ph-4-0CF2Br ch3 ch3 Ph-4-0CF2CHF2 ch3 ch3 Ph-4-0CF2CHFCl ch3 ch3 Ph-4-0CF2CHFBr ch3 ch3 Ph-4-0CF2CF2Br ch3 ch3 Ph-4-0CF2CFC12 ch3 ch3 Ph-4-0CF2CHFCF3 ch3 ch3 Ph-4-0CH (CF3)2 ch3 ch3 Ph-4-0CF2CFBrCF3 ch3 ch3 Ph-4_0CF2CHF0CF3 ch3 ch3 Ph-4-0CF2CHF0CF2CF2CF3 ch3 ch3 Ph-4-0S02CH3 ch3 ch3 Ph-4-0S02CF3 ch3 ch3 Ph-4-0 (Ph-4 - CF3) ch3 ch3 Ph-4-0 (L - 45g&gt; ch3 ch3 Ph-4-0 (L-451) ch3 ch3 Ph-4-SCH3 ch3 ch3 PH - S (0) CH3 ch3 ch3 Ph-4_S02CH3 ch3
536 314918 200407073 ch3 Ph+SCF3 CH ch3 Ph-4-S (0) CF3 CH ch3 Ph-4-S02CF3 CH ch3 Ph-4-N02 CH ch3 Ph-4-CN CH ch3 Ph-4-C (0)NH2 CH ch3 Ph - 4-C ⑸ NH2 CH； ch3 Ph-3, 4-F2 CH； ch3 Ph-3-F-4-C1 CH； ch3 Ph-3-F~4-CF3 CH： ch3 Ph-3-F-4-0CHF2 CH: ch3 Ph-3-F-4_0CF3 CH； ch3 Ph-3-F-4-0CF2Br CH； ch3 Ph-3, 4-Cl2 CH, ch3 Ph-3, 4-Βγ2 CH： ch3 2-Naph CH： ch3 L-lc CH, ch3 L-ld ch2 ch3 L~le ch5 ch3 L-li CHj ch3 L-2b ch2 ch3 L - 3c CHa ch3 L-3d ch3 ch3 L - 3e ch3 ch3 L-3f ch3 ch3 L-3k ch3 ch3 L-31 ch3 ch3 L-3o ch3 ch3 L_4b ch3 ch3 L-4c ch3 ch3 L-lOc ch3 ch3 L-22c ch3 ch3 L-23c ch3 ch3 L - 31b ch3 ch3 卜45d ch3 ch3 L - 45e ch3 ch3 L - 45i ch3
537 314918 200407073 ch3 L - 45g ch3 ch3 L - 45m ch3 ch3 L-46d ch3 ch3 L - 46e ch3 ch3 L - 46i ch3 ch3 L - 46g ch3 ch3 L - 46j ch3 ch3 L - 46k ch3 ch3 L - 46r ch3 ch3 L-47a ch3 ch3 卜47e ch3 Et cf3 Ph-4-F Et cf3 Ph-4-Cl Et cf3 Ph-4-Br Et cf3 Ph-4-CF3 Et cf3 Ph-4-0CHF2 Et cf3 Ph-4-OCFs Et cf3 Ph+S02CH Et Ph-4-0CF3 ch3 Et Ph-4-0 (L-45g) ch3 cf3 cf3 Ph-4-Cl cf3 cf3 Ph+S02CH ch2oh cf3 Ph-4-F ch2oh cf3 Ph-4-Cl ch2oh cf3 Ph-4-Br ch2oh cf3 Ph-4-CF3 ch2oh cf3 Ph-4-0CHF2 ch2oh cf3 Ph-4-0CF3 ch2oh cf3 Ph-4-S02CH ch2oh Ph-4-0CF3 ch3 ch2oh Ph - 4 -0(L-45g) ch3 och3 cf3 Ph-4~F och3 cf3 Ph-4-Cl och3 cf3 Ph+Br och3 cf3 Ph-4-CF3 och3 cf3 Ph-4-0CHF2 och3 cf3 Ph-4-OCFa
538 314918 200407073 och3 cf3 Ph+S02CH3 och3 Ph-4-0CF3 ch3 0CH3 Ph-4-0 (L-45g) ch3 sch3 cf3 Ph-4-F sch3 cf3 Ph-4-C1 sch3 cf3 Ph-4-Br sch3 cf3 Ph+CF3 sch3 cf3 Ph-4-0CHF2 sch3 cf3 Ph-4-0CF3 sch3 cf3 Ph-4-S02CH3 sch3 Ph-4-0CF3 ch3 sch3 Ph-4-0 (L-45g) ch3 SPr-i cf3 Ph+Cl SPr - i cf3 Ph-4-S02CH3 ch3 cf3 Ph-3-0 (Ph-4~C1) ch3 cf3 Ph-4-0 (Ph-4-Cl) ch3 cf3 Ph_3 - 0 (Ph-4 - Br) ch3 cf3 Ph-4 - 0 (Ph - 4HBr) ch3 cf3 Ph-4-0 (L-45e) ch3 cf3 Ph-4-0 a-48b) ch3 cf3 Ph - 3-S (Ph+Cl) ch3 cf3 Ph-4-S (Ph-4-Cl) ch3 cf3 Ph+S (PH-Br&gt; ch3 cf3 Ph-4-S (Ph-4-Br) ch3 cf3 Ph-4-S (L - 45e) ch3 cf3 Ph-4-S (L-45g) ch3 cf3 Ph-4-S(L-451) ch3 cf3 Ph-4-S (L-48b) ch3 Ph-4-0 (Ph-4-Cl) ch3 ch3 Ph-4-0(Ph-4-Br) ch3 ch3 Ph-4-0(L-21c) ch3 ch3 Ph-4-0 (L-21e) ch3 ch3 Ph~4-0(L-45e) ch3 ch3 Ph - 4 -0 (L - 48b) ch3 ch3 Ph - 4-S (Ph-4-Cl) ch3 ch3 Ph - 4-S (Ph-4 - Br&gt; ch3 ch3 Ph-4-S (Ph-4-CF3) ch3
314918 200407073 ch3 Ph-4-S (L-21c) CH； ch3 Ph-4*S a-21e) CH； ch3 Ph-4~S (L~45e) CH； ch3 Ph-4-S (L-45g) CH； ch3 Ph-4-S (L-451) CH； ch3 Ph-4-S a-48b) CH： 第7表 ΟΥ Υ
[6] · 1 或 [6] · 2 Y R4 R6j R6k R6丨 R5 F Ph-4-F F F H H F Ph-4-Cl F F H H F Ph-4-Cl Cl Cl H H F Ph-4-Br F F H H F Ph+CF3 F F H H F PH -OCHF2 F F H H F Ph+0CF3 F F H H F Ph-4-0CF3 Cl Cl H H F Ph-4-0CF2Br F F H H F Ph-4-0CF2CHF2 F F H H F Ph~4-0CF2CHFCF3 F F H H F Ph-4-0CF2CHF0CF2CF2CF3 F F H H F Ph - 4 -0&lt;L-45g) F F H H F Ph-4 - 0 (L-45g) Cl Cl H H F Ph-3, 4~C12 F F H H Cl Ph-4-F F F H H Cl Ph-4-F Cl Cl H H Cl Ph-4-Cl F F H H Cl Ph-4~C1 Cl Cl H H Cl Ph+Br F F H H 540 314918 200407073 C1 Ph+Br Cl C1 Ph-4-CF3 F C1 Ph-4-CF3 Cl C1 Ph-4_0CHF2 F C1 Ph-4-0CHF2 Cl C1 Ph-4-0CF3 F C1 Pb-4-0CF3 Cl C1 Ph-4-0CF2Br F C1 Ph-4-OCFsBr Cl C1 Ph-4-0CF2CHF2 F C1 Ph-4-0CF2CHF2 Cl C1 Ph-4-0CF2CHFCl F C1 Ph-4-0CF2CHFC1 Cl C1 Ph-4-0CF2CHFCF3 F C1 Ph-4-0CF2CHFCF3 Cl C1 Ph-4-0CF2CHF0CF3 F C1 Ph-4-0CF2CHF0CF3 Cl C1 Ph-4-0CF2CHF0CF2CF2CF3 F C1 Ph-4-0CF2CHF0CF2CF2CF3 Cl C1 Ph-4-0 (L-45g) F C1 Ph - 4-0 (L - 45g) Cl C1 Ph-3, 4-F2 F C1 Ph-3, 4-F2 Cl C1 Ph-3-F-4-C1 F C1 Ph-3-F-4-Cl Cl C1 Ph-3t 4-Cl2 F C1 Ph-3, 4-C12 Cl C1 L-45d F C1 L-45d Cl C1 L-45e F C1 L~45e Cl C1 L-45g F C1 L-45g Cl C1 L_45m F C1 L - 45m Cl C1 L - 46d F C1 L&gt;46d Cl
Cl Η Η F Η Η
Cl Η Η F Η Η C1 Η Η F Η Η C1 Η Η F Η Η C1 Η Η F Η Η C1 Η Η C1 Η Η F Η Η C1 Η Η F Η Η C1 Η Η F Η Η C1 Η Η F Η Η C1 Η Η C1 Η Η F Η Η C1 Η Η F Η Η C1 Η Η F Η Η C1 Η Η F Η Η C1 Η Η F Η Η C1 Η Η F Η Η C1 Η Η
54】 314918 200407073
Cl L-46e F F H H Cl L - 46e Cl Cl H H Cl L - 46g F F H H Cl L-46g Cl Cl H H Cl L-46r F F H H Cl L-46r Cl Cl H H Cl L-47a F F H H Cl L-47a Cl Cl H H Cl L - 47e F F H H Cl L-47e Cl Cl H H Br Ph-4-F F F H H Br Ph-4-Cl F F H H Br Ph-4-Cl Cl Cl H H Br Ph-4-Br F F H H Br Ph-4-CF3 F F H H Br Ph-4~0CHF2 F F H H Br Ph-4-0CF3 F F H H Br Ph-4-0CF3 Cl Cl H H Br Ph-4-0CF2Br F F H H Br Ph-4-0CF2CHF2 F F H H Br Ph-4-0CF2CHFCF3 F F H H Br Ph-4-0CF2CHF0CF2CF2CF3 F F H H Br Ph-4-0 (L-45g) F F H H Br Ph-4-0 (L-45g) Cl Cl H H Br Ph-3, 4-Cl2 F F H H Br L-45e F F H H Br L - 45g F F H H Br L - 46e F F H H Br L - 46g F F H H 1 Ph+Cl F F H H I Ph-4-C1 Cl Cl H H I Ph-4-0CF3 F F H H I Ph-4-0CF3 Cl Cl H H I Ph-4-0 (L-45g) F F H H I Ph-4-0 (L-45g) Cl Cl H H ch3 F H H H Ph-4-F ch3 F H H H Ph-4-Cl
542 314918 200407073 CHa CH3 ch3 CHa CHa CH3 ch3 CHs ch3 ch2
H H H H H H H H
H H H H H H H H H H H H H H H H H H H Cl
Ph-4-Br Ph-4-CF3 Ph-4-0CHF2 Ph-4-0CF3 Ph-4-SCH3 Ph+S ⑼ CH3 Ph-4-S02CH3 Ph-4-CN Ph-3, 4-Cl2 Ph-4-Cl ch3 F H H Br Ph-4-Cl ch3 F F F H Ph-4-F ch3 F F F H Ph-4-Cl ch3 F F F H Ph+Br ch3 F F F H Ph-4-CF3 ch3 F F F H Ph-4-0CHF2 CH3 F F F H Ph-4-0CF3 CH3 F F F H Ph-4-S02CH3 ch3 F F F H Ph-3f 4-Cl2 ch3 F Cl Cl H Ph+Cl ch3 F Cl Cl H Ph-4-S02CH3 ch3 F CN CN H H ch3 Cl H H H Ph-4-F ch3 Cl H H H Ph-4-Cl ch3 Cl H H H Ph+Br ch3 Cl H H H Ph-4-I ch3 Cl H H H Ph-4-CF3 ch3 Cl H H H Ph-4-0CHF2 ch3 Cl H H H Ph-4~0CF3 ch3 Cl H H H Ph-4-0CF2Br ch3 Cl H H H Ph-4-0CF2CHF2 ch3 Cl H H H Ph-4-0CF2CHFC1 ch3 Cl H H H Ph-4-0CF2CHFCF3 ch3 Cl H H H Ph-4~0CF2CHF0CF ch3 Cl H H H Ph-4-0S02CH3 ch3 Cl H H H Ph-4-0S02CF3 ch3 Cl H H H Ph - 4 -0 (L-45g)
543 314918 200407073 ch3 Cl H H H Ph-4-SCH3 ch3 Cl H H H Ph-4~S(0)CH； ch3 Cl H H H Ph-4-S02CH3 ch3 Cl H H H Ph+CN ch3 Cl H H H Ph_4_(M0)NH: ch3 Cl H H H Ph - 4-C ⑸ NH: ch3 Cl H H H Ph-3, 4-F2 ch3 Cl H H H Ph - 3-F+C1 ch3 Cl H H H Ph-3,4-Cl2 ch3 Cl H H H L-45d ch3 Cl H H H L~45e ch3 Cl H H H L-45I ch3 Cl H H H L-45g ch3 Cl H H H L-45h ch3 Cl H H H L~45ffl ch3 Cl H H H L-46d ch3 Cl H H H L-46e ch3 Cl H H H L-46f ch3 Cl H H H L~46g ch3 Cl H H H L - 46j ch3 Cl H H H L-46k ch3 Cl H H H L-46q ch3 Cl H H H L - 46r ch3 Cl H H H L-47a ch3 Cl H H H L - 47e ch3 Cl H H Cl Ph+F ch3 Cl H H Cl Ph-4-Cl ch3 Cl H H Cl Ph-4-Br ch3 Cl H H Cl Ph-4-CF3 ch3 Cl H H Cl Ph-4-0CHF2 ch3 Cl H H * Cl Ph-4-0CF3 ch3 Cl H H Br Ph-4-F ch3 Cl H H Br Ph-4-Cl ch3 Cl H H Br Ph-4HBr ch3 Cl H H Br PM - CF3 ch3 Cl H H Br Pb-4-0CHF2 ch3 Cl H H Br Ph-4_0CF3 544 314918 200407073
ch3 Cl F F H Ph-4-F ch3 Cl F F H Ph-4-Cl ch3 Cl F F H Ph~4~Br ch3 Cl F F H Ph+CF3 ch3 Cl F F H Ph-4-0CHF2 ch3 Cl F F H Ph-4-0CF3 ch3 Cl F F H Ph-4-0S02CH3 ch3 Cl F F H ph-sch3 ch3 Cl F F H Ph-4-S (0) CH3 ch3 Cl F F H Ph-4-S02CH3 ch3 Cl F F H Ph-4-CN ch3 Cl F F H Ph - 4-C(0)NH2 ch3 Cl F F H Ph-4_C ⑸ NH2 ch3 Cl F F H Ph-3, 4-F2 ch3 Cl F F H Ph~3~F~4~Cl ch3 Cl F F H Ph-3, 4-Cl2 ch3 Cl F F H L-46d ch3 Cl Cl Cl H Ph-4-F ch3 Cl Cl Cl H Ph-4-Cl ch3 Cl Cl Cl H Ph-4-Br ch3 Cl Cl Cl H Ph+CF3 ch3 Cl Cl Cl H Ph-4-0CHF2 ch3 Cl Cl Cl H Ph-4-0CF3 ch3 Cl Cl Cl H Ph+S02CH3 ch3 Cl Cl Cl H Ph-3, 4-C12 ch3 Cl ch3 H H Ph~4~F ch3 Cl ch3 H H Pli-4-Cl ch3 Cl ch3 H H Ph+Br ch3 Cl ch3 H H Ph-4-0CF3 ch3 Cl ch3 ch3 H Ph-4-F ch3 Cl ch3 ch3 H Ph-4-Cl ch3 Cl ch3 ch3 H Ph-4-Br ch3 Cl ch3 ch3 H Ph-4-0CF3 ch3 Cl Et H H Ph+Cl ch3 Cl n-Pr H H Ph+Cl ch3 Cl i-Pr H H Ph-4-Cl ch3 Cl CN CN H H
545 314918 200407073
ch3 Cl CN CN H Ph-4-Cl ch3 Cl CN CN H Ph-4-0CF3 CH3 Br H H H Ph-4-F ch3 Br H H H Ph-4-Cl ch3 Br H H H Ph+Br ch3 Br H H H Ph~4-CF3 ch3 Br H H H Ph-4-0CHF2 ch3 Br H H H Ph-4-0CF3 ch3 Br H H H Ph-4-0S02CH ch3 Br H H H Ph-4-SCH3 ch3 Br H H H Ph-4-S(0)CH； ch3 Br H H H Ph-4-S02CH3 ch3 Br H H H Ph-4-CN ch3 Br H H H Ph-4~C(0)NH； ch3 Br H H H Ph-4-C ⑸ NH: ch3 Br H H H Ph~3, 4~F 2 ch3 Br H H H Ph-3-F-4-Cl ch3 Br H H H Ph-3,4-Cl2 ch3 Br H H H L - 46d ch3 Br H H Cl Ph-4-Cl ch3 Br H H Br Ph-4-Cl ch3 Br F F H Ph-4-F ch3 Br F F H Ph-4-Cl ch3 Br F F H Ph-4-Br ch3 Br F F H Ph-4-CF3 ch3 Br F F H Ph-4-0CHF2 ch3 Br F F H Ph-4-0CF3 ch3 Br F F H Ph-4-SCH3 ch3 Br F F H Pb+S(0)CH: ch3 Br F F H Ph-4-S02CH3 ch3 Br F F H Ph-3. 4-Cl2 ch3 Br F F H L-46d ch3 Br F F Cl Ph+Cl ch3 Br F F Br Ph-4-Cl ch3 Br Cl Cl H Ph+Cl ch3 Br Cl Cl H Ph-4~S02CH3 ch3 Br CN CN H H 546 314918 200407073
ch3 ch3 H H H Ph-4-F ch3 ch3 H H H Ph-4-Cl ch3 ch3 H H H Ph-4-Br ch3 ch3 H H H Ph-4-CF3 ch3 ch3 H H H Ph+0CHF2 ch3 ch3 H H H Ph-4-0CF3 ch3 ch3 H H H Ph-4-S02CH3 ch3 ch3 H H Cl Ph+Cl ch3 ch3 H .H Br Ph+Cl ch3 ch3 F F H Ph-4-F ch3 ch3 F F H Ph+Cl ch3 ch3 F F H Ph~4~Br ch3 ch3 F F H Ph-4-CF3 ch3 ch3 F F H Ph-4-0CHF2 ch3 ch3 F F H Ph-4-0CF3 ch3 ch3 F F H PI1-4-SO2CH3 ch3 ch3 Cl Cl H Ph-4-Cl ch3 ch3 Cl Cl H Ph-4-S02CH3 ch3 ch3 ch3 H H Ph-4-Cl ch3 ch3 ch3 ch3 H Ph+Cl ch3 ch3 CN CN H H ch3 Et H H H Ph+Cl ch3 Et H H H Ph-4-S02CH3 ch3 Et F F H Ph-4-Cl ch3 Et F F H Ph+S02CH3 ch3 Et Cl Cl H Ph+Cl ch3 Et Cl Cl H Ph+S02CH3 ch3 Et ch3 H H Ph-4-Cl ch3 Et CN CN H H ch3 n-Pr H H H Ph-4-Cl ch3 n-Pr ch3 H H Ph+Cl ch3 n - Pr CN CN H H ch3 卜Pr H H H Ph-4-Cl ch3 i - Pr · ch3 H H Ph+Cl ch3 i - Pr CN CN H H ch3 c-Pr F F H H ch3 c - Pr Cl Cl H H 547 314918 200407073 ch3 c-Pr Br Br H H ch3 n-Bu H H H Ph+Cl ch3 s-Bu H H H Ph+Cl ch3 i-Bu H H H Ph-4-Cl ch3 c - Bu F F H H ch3 c-Bu Cl Cl H H ch3 c-Bu Br Br H H ch3 n-Pen H H H PH-C1 ch3 c - Pen F F H H ch3 c-Pen Cl Cl H H ch3 c-Pen Br Br H H ch3 n - Hex H H H Ph+Cl ch3 c-Hex F F H H ch3 c-Hex Cl Cl H H ch3 CH2F CN CN H H ch3 ch2ci CN CN H H ch3 CH2Br CN CN H H ch3 chf2 H H H Ph-4-F ch3 chf2 H H H Ph-4-Cl ch3 chf2 H H H Ph+Br ch3 chf2 H H H Ph-4-CF 3 ch3 chf2 H H H Ph-4-0CHF2 ch3 chf2 H H H Ph-4-0CF3 ch3 chf2 H H H Ph-4-S02CH ch3 chf2 H H Cl Ph+Cl ch3 chf2 H H Br Ph+Cl ch3 chf2 F F H Ph-4-Cl ch3 chf2 Cl Cl H Ph-4~C1 ch3 chf2 ch3 H H Ph~4-Cl ch3 chf2 ch3 ch3 H Ph-4-Cl ch3 chf2 CN CN H H ch3 cf3 H H H Ph-4_F ch3 cf3 H H H Ph-4-Cl ch3 cf3 H H H Ph-4-Br ch3 cf3 H H H Ph-4-0CHF2 ch3 cf3 H H H Ph-4-CF3 ch3 cf3 H H H Ph-4-0CF3 548 314918 200407073
ch3 cf3 H H H Ph+S02CH3 ch3 cf3 H H H Ph-3, 4-F2 ch3 cf3 H H H Ph-3-F-4-Cl ch3 cf3 H H H Ph-3,4-Cl2 ch3 cf3 H H H L-46d ch3 cf3 H H H L~46e ch3 cf3 H H H L-46g ch3 cf3 H H Cl Ph-4-Cl ch3 cf3 H H Br Ph-4-Cl ch3 cf3 F F H Ph-4-Cl ch3 cf3 F F H ph-so2ch3 ch3 cf3 Cl Cl H Ph-4-Cl ch3 cf3 Cl Cl H Ph_4-S02CH3 ch3 cf3 ch3 H H Ph-4-Cl ch3 cf3 ch3 ch3 H Ph-4-Cl ch3 cf3 Et H H Ph-4-C1 ch3 cf3 n - Pr H H PH-Cl ch3 cf3 i-Pr H H Ph+Cl ch3 cf3 CN CN H H ch3 cf2ci H H H Ph+Cl ch3 cf2ci H H H Ph+S02CH3 ch3 cf2ci Cl Cl H Ph-4-Cl ch3 cf2ci CN CN H H ch3 cf2ci ch3 H H Ph_4-Cl ch3 CF2Br CN CN H H ch3 .cf2chf2 CN CN H H ch3 cf2cf3 H H H Ph-4-Cl ch3 cf2cf3 H H H Ph-4-S02CH3 ch3 cf2cf3 Cl Cl H Ph-4-Cl ch3 cf2cf3 CN CN H H ch3 cf2cf3 ch3 H H Ph-4-Cl ch3 cf2cf2ci CN CN H H ch3 CF2CF2Br CN CN H H ch3 CFC1CF3 CN CN H H ch3 CFBrCF3 CN CN H H ch3 CFC1CF2C1 CN CN H H ch3 cf2cf2cf3 CN CN H H
549 314918 200407073
ch3 CF (CF3)2 CN CN H H ch3 CF2CF2CF2CF3 CN CN H H ch3 ch2och3 H H H Ph+Cl ch3 ch2och3 H H H Ph-4-S02CH ch3 ch2och3 F F H H ch3 ch2och3 Cl Cl H H ch3 ch2och3 Br Br H H ch3 ch2och3 CN CN H H ch3 CH20Et H H H Ph-4-Cl ch3 CH20Et H H H Ph-4-S02CH ch3 CH20Et F F H H ch3 CH20Et Cl Cl H H ch3 CH20Et Br Br H H ch3 CH20Et CN CN H H ch3 ch2och2cf3 H H H Ph+Cl ch3 ch2och2cf3 H H H Ph-4-S02CH； ch3 ch2och2cf3 F F H H ch3 ch2och2cf3 Cl Cl H H ch3 ch2och2cf3 Br Br H H ch3 ch2och2cf3 CN CN H H ch3 ch2och2cf2cf3 H H H Ph-4-Cl ch3 ch2och2cf2cf3 H H H Ph-4-S02CH： ch3 ch2och2cf2cf3 F F H H ch3 ch2och2cf2cf3 Cl Cl H H ch3 cf2ocf2cf2ocf3 · F F H H ch3 cf2ocf2cf2ocf3 Cl Cl H H ch3 CF (CF3)〇CF2CF2CF3 F F H H ch3 CF (CF3)〇CF2CF2CF3 Cl Cl H H ch3 ch2sch3 H H H Ph-4-Cl ch3 ch2sch3 H H H Ph+S02CH2 ch3 ch2sch3 F F H H ch3 ch2sch3 Cl Cl H H ch3 ch2sch3 Cl Cl H PH-Cl ch3 ch2sch3 Br Br H H ch3 ch2so2ch3 F F H H ch3 ch2so2ch3 Cl Cl H H ch3 ch2so2ch3 Br Br H H 550 314918 200407073
ch3 CH2SEt F F H H ch3 CH2SEt Cl Cl H H ch3 CH2SEt Br Br H H ch3 ch2scf3 H H H Ph+Cl ch3 ch2scf3 H H H Ph+S02CH ch3 ch2scf3 F F H H ch3 ch2scf3 Cl Cl H H ch3 ch2scf3 Cl Cl H Ph-4-Cl ch3 ch2scf3 Br Br H H CH3 och3 F F H H ch3 och3 Cl Cl H H ch3 so2cf3 H H H H ch3 T-22 F F H H ch3 T-22 Cl Cl H H ch3 T - 23 F F H H ch3 T-23 Cl Cl H H ch3 T-24 F F H H ch3 T_24 Cl Cl H H ch3 Ph F F H H ch3 Ph-4-F F F H H ch3 Ph-4-F F Cl H H ch3 Ph一4-F F Br H H ch3 Ph-4-F Cl Cl H H ch3 Ph-4-F Cl Br H H ch3 Ph-4-F Br Br H H ch3 Ph-4-F CN CN H H ch3 Ph-4-Cl H H H H ch3 Ph-4-Cl F H H H ch3 Ph-4-Cl F H ch3 H ch3 Ph-4-C1 F F H H ch3 Ph+Cl F F F H ch3 Ph+Cl F F F F ch3 Ph+Cl F F F Cl ch3 Ph-4-Cl F F F Br ch3 Ph+Cl F F Cl H ch3 Ph-4-Cl F F Cl Cl ch3 Ph-4-Cl F F Br H 551 314918 200407073
ch3 Ph-4-Cl F F Br Br ch3 Ph+Cl F F ch3 H ch3 Ph+Cl F Cl H H ch3 Ph-4-Cl F Cl ch3 H ch3 Ph+Cl F Br H H ch3 Ph-4-Cl F Br ch3 H ch3 Ph+Cl Cl H H H ch3 Ph-4-C! Cl H ch3 H ch3 Ph-4-Cl Cl Cl H H ch3 Ph-4-Cl Cl Cl ch3 H ch3 Ph-4-CI Cl Br H H ch3 Ph+Cl Br H H H ch3 Ph-4-Cl Br H ch3 H ch3 Ph+Cl Br Br H H ch3 Ph+Cl Br Br ch3 H ch3 Ph-4-Cl CN CN H H ch3 Ph-4-Br F F H H ch3 Ph+Br F F H H ch3 Ph+Br F Cl H H ch3 Ph-4-Br F Br H H ch3 Ph**4~Br Cl Cl H H ch3 Ph+Br Cl Br H H ch3 Ph~4~Br Br Br H H ch3 Ph-4-Br CN CN H H ch3 Ph+I F F H H ch3 Ph-4-I Cl Cl H H ch3 Ph-4-CF3 F F H H ch3 Ph-4-CF3 F Cl H H ch3 Ph-4-CF3 F Br H H ch3 Ph-4-CF3 Cl Cl H H ch3 Ph-4-CF3 Cl Br H H ch3 Ph+CF3 Br Br H H ch3 Ph-4-CF3 CN CN H H ch3 Ph-4-CH20CH2CF3 F F H H ch3 Ph+CH20CH2CF3 Cl Cl H H ch3 Ph-4-C (CF3)2〇H F F H H ch3 Ph-4-C (CF3) 20H Cl Cl H H
552 314918 200407073 ch3 Ph+CH2SCH3 F F ch3 Ph+CH2SCH3 Cl Cl ch3 Ph-4-CH2S(0) CH3 F F ch3 Ph-4-CH2S (0) CH3 Cl Cl ch3 Ph+CH2S02CH3 F F ch3 Ph - 4-CH2S02CH3 Cl Cl ch3 Ph+CH2SEt F F ch3 Ph+CH2SEt Cl Cl ch3 Ph-4-CH2S(0)Et F F ch3 Ph-4 - CH2S(0)Et Cl Cl ch3 PH - CH2S02Et F F ch3 Ph-4-CH2S02Et Cl Cl ch3 Ph-4-CH2SPr-n F F ch3 Ph-4-CH2SPr-n Cl Cl ch3 Ph-4-CH2S02Pr-n F F ch3 Ph-4-CH2S02Pr-n Cl Cl ch3 Ph+CH2SPr-i F F ch3 Ph-4-CH2SPr-i Cl Cl ch3 Ph-4-CH2S02Pr - i F F ch3 Ph-4-CH2S02Pr-i Cl Cl ch3 Ph+CH2SPr-c F F ch3 Ph-4~CH2SPr-c Cl Cl ch3 Ph+CH2S02Pr-c F F ch3 Ph-4-CH2S02Pr-c Cl Cl ch3 Ph-4-CH2SCF3 F F ch3 Ph~4-CH2SCF3 Cl Cl ch3 Ph+CH2S(0)CF3 F F ch3 Ph-4-CH2S(0) CF3 Cl Cl ch3 Ph-4-CH2S02CF3 F F ch3 Ph-4-CH2S02CF3 Cl Cl ch3 Ph+CH2SCH2CF3 F F ch3 Ph-4-CH2SCH2CF3 Cl G1 ch3 Ph-4-0CHF2 F F ch3 Ph~4-0CHF2 F Cl ch3 Ph-4_0CHF2 F Br ch3 Ph-4-0CHF2 Cl Cl ch3 Ph-4-0CHF2 Cl Br
553 314918 200407073 ch3 Ph - [0CHF2 Br Br ch3 Ph-4-0CHF2 CN CN ch3 Ph-4-0CFa H H ch3 Ph-4-0CF3 F H ch3 Ph-4-0CF3 F H ch3 Ph-4-0CF3 F F ch3 Ph-4-0CF3 F F ch3 Ph-4-0CF3 F F ch3 Ph-4-0CF3 F F ch3 Ph-4-0CF3 F F ch3 Ph-4-0CF3 F F ch3 Ph-4-OCF 3 F F ch3 Ph~4~0CF3 F F ch3 Ph-4-OCF3 F F ch3 Ph-4-0CF3 F Cl ch3 Ph-4-0CF3 F Br ch3 Ph-4-0CF3 Cl H ch3 Ph-4-0CF3 Cl H ch3 Ph-4-0CF3 Cl Cl ch3 Ph-4-0CF3 Cl Br ch3 Ph-4-0CF3 Br H ch3 Ph-4-0CF3 Br H ch3 Ph-4-OCF3 Br Br ch3 Ph-4-OCFa CN CN ch3 Ph-4-0CF2Br F F ch3 Ph-4-OCF2Br F Cl ch3 Ph-4-0CF2Br F Br ch3 Ph~4-0CF 2ΒΓ Cl Cl ch3 Ph，4_0CF2Br Cl Br ch3 Ph~4-OCFgBr Br Br ch3 Ph-4-0CF2Br CN CN ch3 Pli-4-0CH2CF3 · F F ch3 Ph-4-0CH2CF3 Cl C! ch3 Ph-4-0CF2CHF2 F F ch3 Ph-4-0CF2CHF2 F Cl ch3 Ph-4_0CF2CHF2 F Br ch3 Ph+OCF2CHF2 Cl Cl Η Η Η Η Η Η Η Η CH3 Η Η Η F Η
F F F C1 F Βγ C1 Η
Cl C1 β Βγ Η Βγ Βγ Η Η Η Η Η Η CH3 Η
554 314918 200407073 ch3 Ph-4-0CF2CHF2 ch3 Ph-4-0CF2CHF2 ch3 Ph-4-0CF2CHF2 ch3 Ph-4-0CF2CHFCl ch3 Ph-4-0CF2CHFCl ch3 Ph+0CF2CHFC1 ch3 Ph-4-0CF2CHFCl ch3 Ph-4_0CF2CHFC1 ch3 Ph-4-0CF2CHFCl ch3 Ph-4-0CF2CHFBr ch3 Ph-4-0CF2CHFBr ch3 Ph-4-0CF2CF2Br ch3 Ph-4-0CF2CF2Br ch3 Ph-4-0CF2CFCl2 ch3 Ph-4-0CF2CFCl2 ch3 Ph+0CF2CC13 ch3 Ph-4-0CF2CCl3 ch3 Ph-4-0CH2CF2CHF2 ch3 Ph-4-0CH2CF2CHF2 ch3 Ph-4-0CF2CHFCF3 ch3 Ph-4-0CF2CHFCF3 ch3 Ph-4-0CF2CHFCF3 ch3 Ph-4-0CF2CHFCF3 ch3 Ph-4~0CF2CHFCF3 ch3 Ph-4-0CF2CHFCF3 ch3 Ph-4-0CF2CHFCF3 ch3 Ph-4-0CH(CF3)2 ch3 Ph-4-0CH(CF3)2 ch3 Ph-4-0CF2CFBrCF3 ch3 Ph-4-0CF2CFBrCF3 ch3 Ph-4-0CF2CHF0CF3 ch3 Ph-4-0CF2CHF0CF3 ch3 Ph-4-0CF2CHF0CF3 CHa Ph-4-0CF2CHF0CF3 ch3 Ph-4-0CF2CHF0CF3 ch3 Ph-4_0CF2CHF0CF3 ch3 Ph-4-0CF2CHF0CF3 200407073
ch3 Ph-4-0CF2CHF0CF2CF2CF3 F ch3 Ph-4-0CF2CHF0CF2CF2CF3 F ch3 Ph-4-0CF2CHF0CF2CF2CF3 F ch3 Ph-4-0CF2CHF0CF2CF2CF3 Cl ch3 Ph-4-0CF2CHF0CF2CF2CF3 Cl ch3 Ph-4-0CF2CHF0CF2CF2CF3 Br ch3 Ph-4-0CF2CHF0CF2CF2CF3 CN ch3 Ph-4-0S02CH3 F ch3 Ph-4-0S02CH3 Cl ch3 Ph-4-0S02Et F ch3 Ph-4-0S02Et Cl ch3 Ph-4~0S02Pr-n F ch3 Ph-4-0S02Pr-n Cl ch3 Ph+0S02Pr-i F ch3 Ph-4-0S02Pr-i Cl ch3 Ph-4-0S02Pr-c F ch3 Ph-4-0S02Pr-c Cl ch3 Ph+0S02CF3 F ch3 Ph~4-0S02CF3 Cl ch3 Ph-4-0(Ph-4 - CF3) F ch3 Ph-4-0 (Ph-4-CF3) Cl ch3 Ph-4-0 (L-45g) F ch3 Ph - 4-0 (L - 45g) F ch3 Ph-4-0 (L-45g) F ch3 Ph-4-0 (L-45g) F ch3 Ph-4-0 (L-45g) Cl ch3 Ph-4-0 (L-45g) Cl ch3 Ph-4-0 (L-45g) Cl ch3 Ph-4^0 (L~45g) Br ch3 Ph-4-0 (L-45g) CN ch3 Ph-4-0 (L-451) F ch3 Ph-4-0 (L-451) Cl ch3 Ph+SCH3 F ch3 Ph+SCH3 Cl ch3 Ph+S ⑼ CH3 F ch3 Ph+S _3 Cl ch3 Ph-4-S02CH3 F
F Η Η
Cl Η Η
Br Η Η CI Η Η Βγ Η Η
Br Η Η CN Η Η F Η Η C1 Η Η F Η Η C1 Η Η C1 Η Η
Br Η Η
Br Η Η CN Η Η F Η Η C1 Η Η F Η Η C1 Η Η F Η Η C1 Η Η F Η Η 556 314918 200407073 ch3 Ph-4-S02CH3 Cl Cl ch3 PH - SEt F F ch3 Ph-4-SEt Cl Cl ch3 Ph-4-S (0)Et F F ch3 Ph+S ⑼ Et Cl Cl ch3 Ph+S02Et F F ch3 Ph+S02Et Cl Cl ch3 Ph-4-SPr-n F F ch3 Ph-4-SPr-n Cl Cl ch3 Ph-4-S (O)Pr-n F F ch3 Ph-4-S (O)Pr-n Cl Cl ch3 Ph~4-S02Pr-n F F ch3 Ph-4-S02Pr-n Cl Cl ch3 Ph-4-SPr-i F F ch3 Ph-4-SPr-i Cl Cl ch3 Ph-4-S (O)Pr-i F F ch3 Ph-4-S (O)Pr-i Cl Cl ch3 Ph-4-S02Pr-i F F ch3 Ph-4-S02Pr-i Cl Cl ch3 Ph-4-SPr-c F F ch3 Ph-4-SPr-c Cl Cl ch3 Ph-4-S(0&gt;Pr - c F F ch3 Ph+S (0) Pr-c Cl Cl ch3 Ph-4-S02Pr-c F F ch3 Ph-4-S02Pr-c Cl Cl ch3 Ph~4~SBu-n F F ch3 Ph-4-SBu-n Cl Cl ch3 Ph - 4-S(0)Bu - n F F ch3 Ph-4~S (0) Bu-n Cl Cl ch3 Ph-4~S〇2Bu~n F F ch3 Ph-4-S02Bu-n Cl Cl ch3 Ph-4~SBu-t F F ch3 Ph-4-SBu-t Cl Cl ch3 Ph-4-S (O)Bu-t F F ch3 Ph-4-S (0) Bu-t Cl Cl ch3 Ph-4-S02Bu-t F F ch3 Ph~4~S〇2Bu-t Cl Cl Η
557 314918 200407073 CH3 Ph-4-SCHF2 CH3 Ph-4-SCHF2 CH3 Ph-4-S (0) CHF2 CH3 Ph~4-S (0) CHF2 CH3 Ph-4-S02CHF2 CH3 Ph-4-S02CHF2 CH3 Ph-4-SCF3 CH3 Ph-4-SCF3 CH3 Ph-4-S (0) CF3 CH3 Ph-4-S (0) CF3 CH3 Ph-4-S02CF3 CH3 Ph-4-S02CF3 CH3 Ph-4-SCF2Cl CH3 Ph-4-SCF2Cl CH3 Ph-4~S (0) CF2C1 CH3 Ph-4-S (0) CF2C1 CH3 Ph-4-S02CF2Cl CH3 Ph-4-S02CF2Cl CH3 Ph-4-SCF2Br CH3 Ph-4-SCF2Br CH3 Ph-4-S (0) CF2Br CH3 Ph-4-S ⑼ CF2Br CH3 Ph-4-S02CF2Br CH3 Ph-4-S02CF2Br CH3 Ph-4-N02 CH3 Ph-4-N02 CH3 Ph-4-N(CH3) 2 CH3 Ph-4-N (CH3) 2
CH3 Ph-4-CN
CH3 Ph+CN CH3 Ph-4-C(0)NH2 CH3 Ph-4-C (0)NH2 CH3 Ph-4-C (0)NHCH3 CH3 Ph-4-C (0)NHCH3 CH3 Ph-4-C (O)NHEt CH3 Ph-4-C (O)NHEt CH3 Ph-4 - C(0)N(CH3)2 200407073 ch3 Ph-4 - C(0&gt;N(CH3)2 Cl Cl ch3 Ph-4-C ⑸ NH2 F F ch3 Ph - 4-C ⑸ NH2 Cl Cl ch3 Ph-*3, 4-F 2 F F ch3 Ph_3, 4-F 2 F Cl ch3 Ph-3, 4-F2 F Br ch3 Ph-3, 4-F2 Cl Cl ch3 Ph-3, 4~F2 Br Br ch3 Ph-3, 4-F2 CN CN ch3 Ph~3~F~4~Cl F F ch3 Ph-3-F-4-Cl F Cl ch3 Ph-3-F-4-Cl F Br ch3 Ph-3~F-4_C1 Cl Cl ch3 Ph-3-F~4-Cl Br Br ch3 Ph-3-F-4-Cl CN CN CH3 Ph-3, 4-Cl2 F F ch3 Ph-3, 4-Cl2 F Cl ch3 Ph-3, 4-Cl2 F Br ch3 Ph-3, 4-Cl2 Cl Cl ch3 Ph-3, 4-Cl2 Br Br ch3 Ph-3, 4-C12 CN CN ch3 Ph-3-F-4-CF3 F F ch3 Ph-3-F-4-CF3 Cl Cl ch3 Ph-3-F-4-0CHF2 F F ch3 Ph-3-F-4-0CHF2 Cl Cl ch3 Ph-3-C卜4-0CHF2 F F ch3 Ph-3-Cl_4-0CHF2 Cl Cl ch3 Ph-3-F-4-0CF3 F F ch3 Ph-3-F-4-0CF3 Cl Cl ch3 Ph+C 卜 4-0CF3 F F ch3 Ph-3-Cl-4-0CF3 Cl Cl ch3 Ph-3*F-4^0CF2Br F F ch3 Ph-3-F-4-0CF2Br Cl Cl ch3 L-lb F F ch3 L-lb Cl Cl ch3 L-lc F F ch3 L - lc Cl Cl
559 314918 200407073
ch3 L-ld F F H H ch3 L - Id Cl Cl H H ch3 L-le F F H H ch3 Me Cl Cl H H ch3 L-lf F F H H ch3 L-lf Cl Cl H H ch3 L-lg F F H H ch3 L-lg Cl Cl H H ch3 L - lh F F H H ch3 L-lh Cl Cl H H ch3 L-li F F H H ch3 L-li Cl Cl H H ch3 L-2b F F H H ch3 L-2b Cl Cl H H ch3 L-3b F F H H ch3 L-3b Cl Cl H H ch3 L - 3c F F H H ch3 L - 3c Cl Cl H H ch3 L-3d F F H H ch3 L**3d Cl Cl H H ch3 L-3e F F H H ch3 L-3e Cl Cl H H ch3 L-3i F F H H ch3 L-3i Cl Cl H H ch3 L-3g F F H H ch3 L-3g Cl Cl H H ch3 L-3h F F H H ch3 L-3h Cl Cl H H ch3 L~3i F F H H ch3 L-3i Cl Cl H H ch3 L - 3j F F H H ch3 L-3j Cl Cl H H ch3 L - 3k F F H H ch3 L-3k Cl Cl H H ch3 L~31 F F H H ch3 L-31 Cl Cl H H ch3 L - 3m F F H H 560 314918 200407073 CH3 L*3ib CH3 L-3n CH3 L-3n CH3 L-3o CH3 L-3o CH3 L-4b CH3 L-4b CH3 L-4c CH3 L-4c CH3 L-4d CH3 L-4d CH3 L-4e CH3 L-4e CH3 L-lOb CH3 L-lOb CH3 L-lOc CH3 L-lOc CH3 L-lOd CH3 L-lOd CH3 L-16a CH3 L-16a CH3 L_16b CH3 L-16b CH3 L-21b CH3 L-21b CHS L-21c CH3 L-21c CH3 L-21d CH3 L-21d CH3 L-21e CH3 L-21e CH3 L-21f CH3 L-21f CH3 L-22b CH3 L-22b CH3 L-22c CH3 L-22c 200407073 CH3 L-22d CH3 L-22d CH3 L-23b CH3 L-23b CH3 L-23c CH3 L~23c CH3 L-23d CH3 L-23d CH3 L-23e CH3 L-23e CH3 L-30a CH3 卜 30a CH3 L - 31a CH3 L~31a CH3 L-31b CH3 L-31b CH3 L-31c CH3 L_31c CH3 L-45a CH3 L~45a CH3 L-45c CH3 L-45c CH3 L-45d CH3 L-45d CH3 L-45e CH3 L-45e CH3 L-45i CH3 L-45i CH3 卜 45g CH3 L-45g CH3 L-45h CH3 L-45h CH3 L-45m CH3 L-45m CH3 L-46a CH3 L-46a CH3 L-46c 200407073 CH3 L-46c CH3 L-46d CH3 L-46d CH3 L-46e CH3 L-46e CH3 L-46f CH3 L-46f CH3 L~46g CH3 L-46g CH3 L-46h CH3 L-46h CH3 L - 46i CH3 L-46i CH3 L-46j CH3 L-46j CH3 L-46k CH3 L-46k CH3 L-46m CH3 L-46m CH3 L-46n CH3 L-46d CH3 L-46o CH3 L-46o CH3 L-46p CH3 L-46p CH3 L-46q CH3 L-46q CH3 L-46r CH3 L-46r CH3 L-47a CH3 L-47a CH3 L-47e CH3 L-47e CH3 L~50b CH3 L-5〇b CH3 L-50c CH3 L-50c 200407073
ch3 L - 50d F F H H ch3 L-50d Cl Cl H H ch3 L-50e F F H H ch3 L-50e Cl Cl H H ch3 L - 50i F F H H ch3 L-50f Cl Cl H H ch3 L-51b F F H H ch3 L-51b Cl Cl H H CHs L-51c F F H H ch3 L-51c Cl Cl H H Et Ph-4-Cl F F H H Et Ph+0CF3 F F H H CH20H Ph+Cl F F H H ch2oh Ph+Cl Cl Cl H H ch2oh Ph+0CF3 F F H H ch2oh Ph-4-0CF3 Cl Cl H H och3 Ph-4-Cl F F H H och3 Ph-4-0CF3 F F H H sch3 Ph-4-Cl F F H H sch3 Ph-4-0CF3 F F H H ch3 CN H H H Ph-4-F ch3 CN H H H Ph+Cl ch3 CN H H H Ph-4，Br ch3 CN H H H PH - CF3 ch3 CN H H H Ph-4-OCHF： ch3 CN H H H Ph-4-OCFa ch3 CN H H H Ph-3, 4-Cl ch3 Ph-4-0 (Ph_4HF) F F H H ch3 Ph-4-0 (Ph-4-F) Cl Cl H H ch3 Ph-4-0(Ph-4-Cl) F F H H ch3 Ph-4-O(Ph-4-Cl) Cl Cl H H ch3 Ph-4-0 (Ph - 4-Br) F F H H ch3 Ph-4-0(Ph-4 - Br&gt; Cl Cl H H ch3 Ph-4~0(Ph-4-0CF3) F F H H ch3 Ph-4-0 (Ph-4-0CF3) Cl Cl H H ch3 Ph-4-0(L-21b) F F H H ch3 Ph-4-0 (L-21b) Cl Cl H H
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ch3 Ph-4-0 (L-21c) F F H H ch3 Ph-4-0(L-21c) Cl Cl H H ch3 Ph-4-0(L - 21d&gt; F F H H ch3 Ph-4-0 (L-21d) Cl Cl H H ch3 Ph-4 - 0(L - 21e) F F H H ch3 Ph-4-0 a-21e) Cl Cl H H ch3 Ph-4-0 a-45c) F F H H ch3 Ph-4-0 (L-45c) Cl Cl H H ch3 Ph-3-0(L-45d) F F H H ch3 Ph-3-0 (L~45d) Cl Cl H H ch3 Ph-4-0(L - 45d) 、F F H H ch3 Ph-4-0 (L-45d) Cl Cl H H ch3 Ph-3-0 a-45e) F F H H ch3 Ph-3 - 0(L - 45e) Cl Cl H H ch3 Ph-4-0 a-45e) F F H H ch3 Ph-4-0 a-45e) Cl Cl H H ch3 Ph-4-0 (L -45f) F F H H ch3 Ph-4-0 (L«45f) Cl Cl H H ch3 Ph-3 - 0 (L—45g) F F H H ch3 Ph-3-0 a-45g) Cl Cl H H ch3 Ph-4-0 a-48b) F F H H ch3 Pli - 4-0(L - 48b) Cl Cl H H 本發明化合物，可在低濃度下有效地防除加害於農園 藝：：及樹木等之所謂農業害蟲，寄生於家畜及家禽類之 所谓豕畜害蟲，造成住家等人類生活 右&amp;境中各種不良影響 之所謂衛生害蟲，損害貯藏於倉庫中 中虫 Y之榖物等之所謂貯榖 告蟲，以及在同樣地方中發生及為愛 體動物及甲殼類之任何害蟲。’、之蟎類、線蟲類、軟 使用本發明化合物可|1 方p会 之 轉麵、蟎類、線蟲類 314918 565 200407073 軟體動物及曱殼類，具體而言，例如： 小菜蛾（Plutella xylostella)、球菜夜蛾（Agrotis ipsilon)、蕪菁夜蛾（Agrotis segetum)、棉蛉蟲（Helicoverpa armigera)、亞麻夜蛾（Helicoverpa assulta)、玉米夜蛾 (Helicoverpa zea)、煙草青蟲（Heliothis virescens)、甘藍夜 蛾（Mamestra brassicae)、稻填蛉（Naranga aenescens)、黑點 銀紋夜蛾（Plusia nigrisigna)、栗夜蛾（Pseudaletia
separata)、甜菜夜蛾（Spodoptera exigua)、斜紋夜蛾 (Spodopteralitura)、海灰翅夜蛾（Spodopteralittoralis)、草 地夜蛾（Spodoptera frugiperda)、南部灰翅夜蛾（Spodoptera eridania)、五斑點天蛾（Manduca quinquemaculata)、煙草天 蛾（Manduca sexta)、葡萄果實蛀蟲（Endopiza viteana)、蘋 果潛葉蛾（Lyonetia prunifoliella malinella)、葉掘蛾 (Phyllonorycter ringoneella)、柑橘潛葉蛾（Phyllocnistis
citrella)、棉紅鈴蟲（Pectinophoragossypiella)、桃小食心 蟲（Carposina niponensis)、棉褐帶捲蛾（Adoxophyes orana fasciata)、小茶姬捲葉蛾（Adoxophyes honmai)、茶捲葉蛾 (Homona magnamina)、蘋果蠹蛾（Cydia pomonella)、梨小 食心蟲（Grapholita molesta)、二化螟（Chilo suppressalis)、 稻叢捲葉填（Cnaphalocrocismedinalis)、菜填（Hellula undalis)、歐洲玉米模（Ostrinia nubilalis)、大豆夜蛾 (Pseudoplusia includens)、擬尺護（Trichoplusia ni)、美國 白蛾（Hyphantria cunea)、日本紋白蝶（Pieris rapae crucivora) 及直紋稻苞蟲（Parnara guttata)等鱗翅目害蟲； 566 314918 200407073
紅腳青銅金龜（Anomala cuprea)、大豆青銅金龜 (Anomala rufocuprea)、曰本金龜（Popillia japonica)、馬铃 薯甲蟲（Leptinotarsa decemlineata)、墨西哥豆瓢蟲 (Epilachna varivestis)、櫛叩頭蟲（Melanotus tamsuyensis)、煙曱蟲（Lasioderma serricorne)、達美樂甲蟲 (Epuraea domina)、茄二十八星瓢蟲（Henosepilachna vigintioctopunctata)、茶粉蟲（Tenebrio molitor)、擬榖盜蟲 (Tribolium castaneum)、斑星天牛（Anoplophora malasiaca)、松褐天牛（Monochamus alternatus)、綠豆象蟲 (Callosobruchus chinensis)、黃守瓜蟲（Aulacophora femoralis)、水稻負泥蟲（Oulema oryzae)、黃條葉蚤 (Phyllotreta striolata)、甘藷犧象（Cylas formicarius)、棉鈴 象蟲（Anthonomus grandis)、稻象蟲（Ethinocnemus squameus)、紫苜蓿葉象（Hypera postica)、美洲象蟲 (Lissorhoptrus oryzophilus)、玉米象蟲（Sitophilus zeamais)、獵食榖象蟲（Sphenophrus venatus vestius)、榖象 蟲（Sitophilus granarius)、黃瓜甲蟲（Diabrotica undecimpunctata)、玉米根蟲（Diabrotica virgifera)、巴貝里 曱蟲（Diabrotica barberi)及毒隱翅蟲（Paederus fuscipes)等 鞘翅目害蟲； 甘藍菜椿（Eurydema rugosa)、白星椿象（Eysarcoris ventralis)、黃斑椿象（Halyomorpha mista)、稻綠椿（Nezara viridula)、中國蛛緣椿象（Leptocorisa chinensis)、豆椿 (Riptortus clavatus)、熱帶多哥蟲（T〇g0 hemipterus)、美國 567 314918 200407073 牧草盲椿（Lygus lineolaris)、棉花跳蚤（pseudatomoscelis seriatus)、香無花編蟲（Stephanitis pyrioides)、雞體蟲 (Epiacanthus stramineus)、茶綠葉蟬（Empoasca onukii)、馬 鈴薯葉蟬（Empoasca fabae)、水稻黑尾葉蟬（Nephotettix cinctinceps)、斑飛蝨（Laodelphax striatellus)、水稻飛蝨 (Nilaparvata lugens)、白背飛虱（Sogatella furcifera)、非洲 木蝨（Trioza erytreae)、梨木蝨（pSylla pyriSUga)、銀葉粉蝨 (Bemisia argentifolii)、煙草粉蝨（Bemisia tabaci)、柑桔粉 _ 蝨（Dialeurodes citri)、溫室粉蝨（Trialeurodes vaporariorum)、棉蚜（Aphis gossypii)、蘋果蚜蟲（Aphis pomi)、桃蚜（Myzuspersicae)、草履介殼蟲（Drosicha corpulenta)、吹棉介殼蟲（Icerya purchasi)、柑桔粉介殼蟲 (Planocoecus citri)、桑粉介殼蟲（Pseudococcus comstocki)、紅犧介殼蟲（Ceroplastes rubens)、矢尖介殼蟲 (Unaspis yanonensis)及溫帶臭蟲（Cimex lectularius)等半翅 S害蟲； 春 西方花薊馬（Frankliniella occidentalis)、花薊馬 (Frankliniella intonsa)、小黃葡馬（Scirtothrips dorsalis)、 南黃薊馬（Thrips palmi)及蔥薊馬（Thrips tabaci)等總翅目 害蟲； 東方果實繩（Dacus dorsalis)、瓜實繩（Dacus cucurbitae)、地中海果實蠅（Ceratitis capitata)、稻小潛葉 繩（Hydrel lia gri seo】a)、蕃蘇斑潛虫骚（Liriomyza bryoniae)、 非洲菊斑潛蠅（Liriomyza trifolii)、種蠅（Hylemya 568 314918 200407073
platura)、蘋果果實蠅（Rhagoletispomonella)、黑森癭蚊 (Mayetiola destructor)、普通家蠅（Muscadomestica)、廄螫 蠅（Stomoxys calcitrans)、綿羊蝨蠅（Melophagus ovinus)、 牛皮蠅（Hypoderma bovis)、紋皮蠅（Hypoderma lineatum)、 羊狂蠅（Oestrus ovis)、非洲采采蠅（須舌蠅（Glossina palpalis)及刺舌繩（Glossina morsitans))、條斑原蚋 (Prosimulium yezoensis)、三角虻（Tabanus trigonus)、大峨 蚋（Telmatoscopus albipunctatus)、日本蠓（Leptoconops nipponensis)、淡色庫蚊（Culexpipienspallens)、埃及斑蚊 (Aedes aegypti)、白紋伊蚊（Aedes albopicutus)及中華瘧蚊 (Anopheles hyracanus sinesis)等雙翅目害蟲；
久里葉蜂（Apethymus kuri)、日本黃翅菜葉蜂（Athalia rosae japonensis)、松鋸蠅（Neodiprion sertifer)、埃西頓蟻 (巴氏埃西頓蟻（Eciton burchelli)及施氏埃西頓犧（Eciton schmitti))、曰本弓背蟻（Camponotus japonicus)、中國虎頭 蜂（Vespa mandarina)、猛犬蟻屬（Myrmecia spp·)、火蟻屬 (Solenopsis spp·)及小黃家蟻（Monomorium pharaonis)等 膜翅目害蟲； 黑胸蟑螂（Periplaneta fuliginosa)、曰本蟑螂 (Periplaneta japonica)及德國蟑螂（Blattella germanica)等 網翅目害蟲； 黑蟋蟀（Teleogryllus emma)、非洲螻蛄（Gryllotalpa africana)、飛蝗（Locustamigratoria)、條斑稻虫皇（〇Xya 7 62(^113丨5)及沙漠飛蝗（8(：11丨51〇{€1^3 81乂8&amp;1*丨3)等直翅目害 314918 569 200407073 蟲， 家白議（Coptotermes formosanus)、黃肢散白蟻 (Reticulitermes speratus)及黑翅 土白蟻（〇d〇ntotermes formosanus)等白蟻目害蟲； 書苗蛋（Ctenocephalidae felis)、人蛋（Pulex irritans)及印 度鼠蚤（Xenopsyllacheopis)等之等翅目害蟲； 雞體蟲（Menacanthus stramineus)及牛體兹（Bovicola bovis)等 hazilami 目害蟲； 牛蝨（Haematopinus eurysternus)、豬蝨（Haematopinus suis)、長鼻 I苗兹（Linognathus vituli)及節兹（Solenopotes capillatus)等之兹目害蟲； 柑桔葉蹣（Panonychus citri)、蘋果葉蟎（panonyChus ulmi)、神澤葉蟎（Tetranychus kanzawai)及二點葉蟎 (Tetranychus urticae)等葉彌類， 茶镫癭蟎（Acaphylla theae)、菊刺皮癭蟎（Aculops pelekassi)、千葉梨繡癭蟎（Eriophyes chibaensis)、鬱金香 癌蟎（Aceriatulipae)等節蟎類； 茶黃蟎（Polyphoatarsonemus latus)、草莓:廢蠘 (Steneotarsonemus pallidus)等塵蟎類； 腐食酪蟎（Tyrophagus putrescentiae)及羅賓根蠘 (Rhizoglyphus robini)等粉蟎類； 大蜂蟎（Varroa jacobsoni)等蜂蟎類； 微小牛碑（Boophilus microplus)、長角血蜱 (Haemaphysalis longicornis)等真蜱類； 570 314918 200407073 羊滅恙蟲（Psoroptes ovis)等疮恙蟲類； 人济蟎（Sarcoptes scabiei)等疮蟎類； 平曱蟲（Armadillidium vulgare)等甲殼類； 根腐線蟲（Prathylenchus penetrans)、傷殘短體線蟲 (Prathylenchus vulnus)、黃金線蟲（Globodera rostochiensis)、大豆包囊線蟲（Heterodera glycines)、北方 根瘤線蟲（Meloidogyne hapla)、根瘤線蟲（Meloidogyne incognita)及松材線蟲（Bursaphelenchus lignicolus)等線蟲 類； 福壽螺（Ponacea canaliculata)、雙線蛞蝓（Incilaria bilineata)、薄皮蜗牛（Acusta despecta sieboldiana)及三線 蜗牛（Euhadra peliomphala)等軟體動物等，然而本發明並不 僅只限定於此等項目。 再者’本發明化合物對於對有機磷系化合物、胺基曱 酸酯（carbamate)系化合物或除蟲菊精類（pyrethr〇id)化合 物等既存之殺蟲劑已產生抗藥性之害蟲亦有效。 亦即，本發明化合物可在低濃度下有效地防除直翅 目、薊馬目、半翅目、鱗翅目、鞘翅目、膜翅目、雙翅目、 網翅目、等翅目、㈣目、蟎類、蝨類及線蟲類等害蟲。 另-方面，本發明化合物具有對哺乳類、魚類、曱殼類及 益蟲幾乎無不良影響之極有用特點。 ‘使用本發明仆八必》η 士 , 、 、 。物^ ’可與通常之適當固體載體 液體載體混合’更且可依日g …、而要添加界面活性劑、浸透劑 展開劑、增黏劑、凍結防止 I釗 結合劑、固結防止劑、 314918 571 200407073 散劑、消泡劑、防腐劑及分解防止劑等，提供做為實用上 之液劑（soluble concentrate)、乳劑（emulsiHable concentrate)、水合劑（wettable powder)、水溶劑（water soluble powder)、顆粒水合劑（water dispersible granule)、 顆粒水溶劑（water soluble granule)、懸浮劑（suspensi〇n concentrate)、乳濁劑（concentrated emulsion)、分散乳化劑 (suspoemulsion)、微乳化劑（microemulsi〇n)、粉劑（dustaMe powder)、粒劑（granule)、錠劑（tablet)及乳化性凝膠劑 (emulsifiable gel)等任何劑型之製劑。又，從省力化及安 全性提高之觀點而言，亦可將上述任何劑型之製劑封入水 溶性膠囊及水溶性膜袋等水溶性包裝物中而供應。 固體載體，例如為天然礦物質諸如石英、方解石、海 泡石、白雲石、白堊石、高嶺石、葉蠟石、絹雲母、埃洛 石、準埃洛石、木節黏土、蛙目黏土、陶石、董青石 (dichroite)、水鋁英石、白砂、雲母、滑石、皂土、活性 白土酉夂丨生白土、輕石、石夕鎮石（attaPulgite)、浮石及石夕藻 土等，天然礦物質之燒成品諸如燒成黏土、珍珠石、白砂 礼展石、蛭石、美國活性白土（attapulgus 及燒成石夕藻 土等，無機鹽類諸如碳酸鎂、碳酸鈣、碳酸鈉、碳酸氫鈉、 硫酸銨、硫酸鈉、硫酸鎂、磷酸氫二銨、磷酸二氫銨及氯 化鉀等’多糖類諸如葡萄糖、果糖、蔗糖及乳糖等糖類， ^如殺粉、粉末纖維素及糊精等，有機物諸如尿素、尿素 何生物、#息香酸及安息香酸鹽等，楂物類諸如木粉、軟 木粉、玉米穗軸、胡桃殼及煙草莖等，以及肥料諸如飛灰 314918 572 200407073 (fiyash)、白煙（whitecarb〇n)(例如含水合成石夕石、無水合 成石夕石及含水合成矽酸鹽等）等。 液脰载體，例如為芳香族烴類諸如二甲苯、烧基9 3 10專）本、本基一甲本基乙烧及烧基(^或c3等）苹等， 脂，族烴類諸如機油、正石4鼠、異石蠟及環烷等，芳香族 烴類與脂肪族烴類之混合物諸如煤油#，醇類諸如乙醇、 :丙醇、m己醇、苯氧基乙醇及苄醇等，多元醇諸如乙二 、丙醇、-乙-醇、己二醇、聚乙二醇及聚丙二醇等， ，類諸如丙基溶纖劑、丁基溶纖劑、苯基溶纖劑、丙二醇 ^丙一醇單乙鱗、丙二醇單丙®丙二醇單丁醚及 =二醇單苯醚等，酮類諸如苯乙酮、環己酮及γ_丁内酯 寺，酯類諸如脂肪酸甲酯、琥珀酸二烷酯、榖胺酸二烷酯、 己一酸二烷酯及酞酸二烷基酯等，酸醯胺諸如Ν_烷基 (Cl、Cs或c”等）吡咯烷酮等，油脂諸如大豆油、亞麻仁 油、菜籽油、椰子油、棉實油及蓖麻子油等，二甲基亞楓 以及水。 此等固體及液體載體，可單獨使用，亦可2種以上併 用〇 界面活性劑，例如聚環氧乙稀炫基醚、聚環氧乙稀烧 基（單或二）苯基醚、聚環氧乙烯（單、二或三）苯乙烯基苯基 蜒、聚環氧乙烯聚環氧丙烷嵌段聚合物、聚環氧乙烯脂肪 酸（單或二）酯、山梨糖醇酐脂肪酸酯、聚環氧乙烯山梨糖 醇酐脂肪酸酯、蓖麻子油伸乙基氧化物加成物、乙炔二醇、 乙炔醇、乙炔二醇之伸乙基氧化物加成物、乙炔醇之伸乙 314938 573 200407073 基氧化物加成物、及烧基糖苦等非離子性界面活性劑，烧 基硫酸酯鹽、烷基苯磺酸鹽、木質素磺酸鹽、烷基磺酸基 琥珀酸鹽、萘磺酸鹽、烷基萘磺酸鹽、萘磺酸之甲醛水縮 合物之鹽、烧基萘確酸之甲醛水縮合物之鹽、聚環氧乙烯 烧基醚硫酸或磷酸醋鹽、聚環氧乙烯（單或二）烷基苯基醚 硫酸或磷酸酯鹽、聚環氧乙烯（單、二或三）苯乙烯基苯基 醚硫酸或磷酸酯鹽、聚羧酸鹽（例如聚丙烯酸鹽、聚順丁烯 二酸、及順丁烯二酸與烯烴之共聚物等）及聚苯乙烯磺酸鹽 等之陰離子性界面活性劑’烧胺鹽及烷基四級銨鹽等陽離 子性界面活性劑，胺基酸型及甜菜鹼（betaine)型等兩性界 面活性劑，矽酮系界面活性劑以及氟系界面活性劑。 此等界面活性劑之含量，並無特別限定，然而對本發 明之製齊1〇〇重量份而言’㉟常以〇 〇5至2〇重量份之範 圍為較佳。又’此等界面活性劑通常可單獨使用，亦 種以上併用。 z 本發明化合物之施用藥量’雖隨 =法及栽培作物等而有差異，然而一般“，有； 伤里以—公頃平均約〇鳥至抓g為較適當。 成 發明=\出使用本發明化合物之製劑之添加例。然而本 添加例中之「份」意指重量份。 # 下之 0.1至80份 5至98·9份 [水合劑] 本發明化合物 固體載體
3】49】S 574 200407073 界面活性劑 其他 1至10份 〇至5份 此外，可添加例如固紝 [乳劑] °㈠或分解防止劑等 0 · 1至3 0份 45至95份 4·9至15份 〇至1 0份 例如為展開劑及分解防止劑等 本發明化合物 液體載體 界面活性劑 其他 做為其他成份者 [懸浮劑] 本發明化合物 液體载體 界面活性劑 其他 做為其他成份者，例 [顆粒水合劑] 本發明化合物 液體栽體 界面活性劑 其他 0·1至70份 15 至 98.89 份 1至12份 0 · 0 1至3 0份 如為；東結防止劑及增黏劑等。 0.1至90份 0至98.9份 1至20份 0至1 0份 做為其他成份者，例如為結合劑及分解防止劑等。 [液劑] 本發明化合物 0.01至70份 液體栽體 20至99.99份 575 314918 200407073 其他 Μ為其他成份者 [津立劑] 本發明化合物 固體栽體 其他 做為其他成份者 [粉劑] 本發明化合物 固體载體 其他 做為其他成份者 等。 0至10份 例如為凍結防止劑及展開劑等。 〇·〇1至80份 10 至 99.99 份 0至10份 例如為結合劑及分解防止劑等。 0·01至30份 65 至 99.99 份 0至5份 例如為飄散防止劑或分解防止劑
劑例 以下’具體地出示以本發明化合物做為有效成分之製 ，然而本發明之範圍並不以其等為限。 再者，在以下之添加例中之「份」意指重量份。 [添加例1 ]水合劑
本發明化合物編號2-124 葉蠟石 Sorpol 5039 20份 74份 4份 (非離子性界面活性劑及陰離子性界面活性劑之混合物··東 邦化學工業（股）公司之商品名） Caplex #80D 2 份 (合成含水石夕酸··鹽野義製藥（股）公司之商品名 314918 576 200407073 將以上成分均勻地混合，製成水合劑。 [添加例2]乳劑 本發明化合物編號2-124 二甲苯 N_曱基吡咯烷酮 Sorpol 2680 5份 75份 15份 5份 (非離子性界面活性劑及陰離子性界面活性劑之混合物：^ 邦化學工業（股）公司之商品名） 將以上成分均勻地混合，製成乳劑。 [添加例3 ]懸浮劑 本發明化合物編號2-124 ， 25份 Agrisol S-710 10份 (非離子性界面活性劑··花王 有限公$ 々 Runox l〇〇〇c 】之商口口名） 0.5 ^ (陰離子性界面活性劑：東邦化學工&quot; 黃原膠 予工業（股）公司之商品名）
黃原膠 水 將以上成分均勻地混合後 劑。 [添加例4 ]顆粒水合劑 本發明化合物編號2-124 Hitenol NE-1 5 〇·2份 64.3 份 進行溼式粉碎，製成懸
75份 -份 (陰離子性界面活性劑：第一工業制77 Vanirex Ν 、衣萬（股）公司之商 10份 314918 577 (陰離子性界面活性劑：日本製
Caplex 80D (月又）公司之商品名） 10份 (合成含水矽酸：鹽野義製藥（股 之商σ么、 將以上成分均勻地混合粉碎後，、 口口 合，再藉由押出式造粒機造粒加夕里水攪拌混 劑。 订乾燥，製成顆粒水合 [添加例5 ]粒劑 本發明化合物編號2-124 5份 皂土 50份 滑石 45份 將以上成分均勻地混合粉碎 添加少晉7火；}主、、g 合，再藉由押出式造粒機造粒 V ^ Μ掉此 f , ? 違订乾燥，製成粒劑。 [添加例6]粉劑 本發明化合物編號2-124 3份
Caplex 80D 0.5份 (合成含水矽酸：鹽野義製藥（股）公 高嶺石 之商。口名） 95份 石粦酸二異丙醋 1.5份 將以上成分均句地混合粉碎，製成粉劑。 當使用時，將上述製劑用水稀㈣至⑽ 或者不稀釋直接散佈。 又，使用本發明化合物做 辰市之f月況中，亦可依海 需要在製劑或散佈時與其 # 除早劑、各種殺蟲劑、滅虱劑、 殺線蟲劑、殺囷劑、植物生長 长凋即劑、共效劑、肥料或_± 3】49]8 578 200407073 壤改良劑等混合施用。 尤其，藉由與其他農藥或植物荷爾蒙混合施用，可期 待由於施用藥量降低而實現低成本化，且由於混合藥劑之 相乘效果而使殺蟲範圍擴大，因而達到更高之有害生物防 除效果。此時，亦可同時與多種農藥組合。與本發明化合 物混合使用之農藥種類，例如農業化學品手冊（Farm Chemicals Handb〇〇k)1999年版中記載之化合物等。具體而 吕，其一般名稱如以下所例示者，然而未必局限於此等項 目° 术又細劑·阿西本維樂-S-甲基（acibenzolar-S-methyl)、 酿胺基卞醯胺（acylaminobenzamide)、銨乃浦（am〇bam)、 胺丙基膦酸（ampr〇pylfos)、敵菌靈（anilazine)、阿拉可納羅 爾（azaconazole)、亞脫敏（azoxystrobin)、本達樂 (benalaxyl)、麥鏽靈（benodanil)、免賴得（benomyl)、佈生 (benthiazole)、本拉馬可立爾（benzamacril)、樂殺蟎 (binapacryl)、聯苯（biphenyl)、比多農（bitertanol)、本索可 辛（bethoxazine)、波爾多混合液（bordeaux mixture)、保米 黴素（blasticidin-S)、溴克座（bromoconazole)、布瑞莫 (bupirimate)、得威多（buthiobate)、石灰硫合劑（Calcium polysulfide)、四氯丹（captafol)、蓋普丹（captan)、氧氯化 銅（copper oxychloride)、力口普胺（carpropamid)、貝芬替 (carbendazim)、萎鏽靈（carboxin)、CGA-279202(試驗名）、 蠘離丹（chinomethionat)、4-氯-3_ 曱基-1，3-苯并噻唑-2(311)-酮（chlobenthiazone)、氯苯基苯并 口米嗤（chlorfenazol)、氣甲 579 314918 200407073 氧苯（chloroneb)、四氯異丙腈（chlorothalonil)、克氣得 (chlozolinate)、銅合浦（cufraneb)、克絕（cymoxanil)、環克 座（cyproconazol)、赛普洛（cyprodinil)、賽普洛福朗 (cyprofuram)、邁隆（dazomet)、迭巴卡伯（debacarb)、二氯 芬（dichlorophen)、代可洛布特拉羅爾（diclobutrazol)、益發 靈（dichlofluanid)、達滅淨（diclomedine)、大克爛 (dicloran)、乙黴威（diethofencarb)、代可洛賽美特 (diclocymet)、待克利（difenoconazole)、二氟林 (diflumetorim)、5-丁基—2-二曱胺基-6-曱基嘧啶-4-醇 (dimethirimol)、達滅芬（dimethomorph)、達克利 (diniconazole)、達克利-M(diniconazole-M)、白粉克 (dinocap)、二苯胺（diphenylamine)、代匹力希翁 (dipyrithione)、普得松（ditalimfos)、腈硫醌（dithianon)、 敵草隆（dodemorph)、多寧（dodine)、德拉索克沙龍 (drazoxolon)、護粒松（edifenphos)、依普座 (epoxiconazole)、也他孔那洛耳（etaconazole)、依瑞莫 (ethirimol)、依得利（etridiazole)、凡殺同（famoxadone)、 务瑞莫（fenarimol)、芬克座（fenbuconazole)、味唾菌酮 (fenamidone)、芬達洛蘇爛（fendazosulam)、芬福爛 (fenfuram)、環己醯胺殺菌劑（fenhexamid)、拌種咯 (fenpiclonil)、芬普洛匹 π定（fenpr〇pidin)、芬普福 (fenpropimorph)、三苯基錫（fentin)、富爾邦（ferbam)、富 米綜（ferimzone)、扶吉胺（fiuazinain)、護汰寧 (fludioxonil)、2,3-二氯議N-4-氟苯基馬來醯亞胺 580 31^918 200407073 (fluoroimide)、福祿昆孔納羅耳（fluquinconazole)、護石夕得 (flusilazole)、氣硫滅（flusulfamide)、氣多寧（flutolanil)、 護汰芬（flutriafol)、福爾培（folpet)、福賽得（fosetyl-aluminium)、麥穗寧（fuberidazole)、氟拉拉克錫耳 (furalaxyl)、福拉比（furametpyr)、克樂淨（gUazatine)、六 氯苯（hexachlorobenzene)、菲可利（hexaconazole)、殺紋寧 (hymexazol)、依滅列（imazalil)、易胺座（imibenconazole)、 克熱淨（iminoctadine)、依普孔納羅耳（ipconaz〇ie)、丙基喜 樂松（iprobenfos)、依普同（iprodione)、依普羅塞爾連 (isoprothiolane)、纈黴威（iprovalicarb)、嘉賜徽素 (kasugamycin)、克收欣（kresoxim-methy 1)、猛銅浦 (mancopper)、鋅錳乃浦（mancozeb)、錳乃浦（maneb)、滅派 林（mepanipyrim)、滅普寧（mepronil)、甲雙靈（metalaxyl)、 美特孔納羅耳（metconazole)、甲硫胺甲酸5,4-甲磺醯氧苯 酯（methasulfocarb)、免得爛（metiram)、苯氧菌胺 (metominostrobin)、邁克尼（myclobutanil)、MTF-753(試驗 名）、鈉乃浦（nabam)、貳（二曱基二硫胺基甲酸）鎳（nickel bis(dimethyldithiocarbamate))、異丙基尼特羅塔爾 (nitrothal-isopropyl)、尼瑞莫（nuarim〇l)、NNF-9425(試驗 名）、歐克希里農（octhilinone)、曱呋醯胺（ofurace)、歐殺 斯（oxadixyl)、嘉保信（oxyCarboxin)、歐克索孔納羅耳富馬 酸鹽（oxpoconazole fumarate)、彼扶座（pefurazoate)、平克 座（penconazole)、賓克隆（pencycuron)、熱必斯（phthalide)、 彼配拉林（piperalin)、保粒黴素（p0iy0Xins)、碳酸氫鉀 581 314918 200407073 (potassium hydrogen carbonate)、撲殺熱（probenazole)、撲 克拉（prochloraz)、撲滅寧（procymidone)、普拔克_鹽酸鹽 (propamocarb-hydrochloride)、普克利（propiconazole)、曱 基鋅乃浦（propineb)、白粉松（pyrazophos)、比芬諾 (pyrifenox)、派美尼（pyrimethanil)、百快隆（pyroquilon)、 蟎離丹（quinomethionate)、快諾芬（quinoxyfen)、五氯硝基 苯（quintozene)、RH72 8 1 (試驗名）、碳酸氫鈉（sodium hydrogen carbonate)、次氯酸鈉（sodium hypochlorite)、硫 石黃（sulfur)、斯彼羅克殺敏（spiroxamine)、得克利 (tebuconazole)、特克納淨（tecnazene)、四克利 (tetraconazole)、腐絕（thiabendazole)、塞爾迪亞淨 / 米爾内 卜（thiadiazin/milneb)、賽氟滅（thifluzamide)、甲基多保淨 (thiophanate-methyl)、得恩地（thiram)、甲基立枯靈 (tolclofos-methyl)、曱基益發靈（tolylfluanid)、三唾酮 (triadimefon)、三泰隆（toriadimenol)、7-氯-3-咪唑-卜基-1，2,4 -苯并三 -1-氧化物（triazoxide)、三賽哇 (tricyclazole)、三得芬（tridemorph)、特富靈（triflumizole)、 赛福寧（triforine)、特立提孔納羅耳（triticonaz〇ie)、維利黴 素（validamycin)、免克寧（vinci〇z〇iin)、硫酸鋅 (viniconazole)、辞乃浦（Zineb)、益穗（ziram)及香菇菌絲體 萃取液等。 殺細®劑：鏈黴素（streptomycin)、克枯爛 (tecloitalam)、經四環素（0XytetraCyCHne)及歐索林酸 (oxolinic acid)等 〇 582 314918 200407073 殺線蟲劑：楓滅威（aldoxycarb)、克線丹（cadusafos)、 福賽絕（fosthiazate)、吉福松（fosthietan)、歐殺滅（oxamyl) 及芬滅松（fenamiphos)等。 滅乱劑：亞昆蟎（acequinocyl)、三亞蟎（amitraz)、必 芬納雷特（bifenazate)、新殺蟎（bromopropylate)、蟎離丹 (chinomethionat)、克氯苯（chlorobezilate)、布賜芬 (clofentezine)、賽赫可沙汀（cyhexatine)、大克梁（dicofol)、 得氯蟎（dienochlor)、依殺蟎（etoxazole)、芬殺蟎 (fenazaquin)、分佈賜（fenbutatin oxide)、芬普寧 (fenpropathrin)、芬普蟎（fenproximate)、合芬寧 (halfenprox)、合賽多（hexythiazox)、密滅汀（milbemectin)、 歐果多（propargite)、畢達本（pyridaben)、畢汰芬 (卩}^11^(11£611)及吡蟎胺(^131^61^}^&amp;(1)等。 殺蟲劑：阿巴汀（abamectin)、歐殺松（acephate)、亞滅 培（acetamiprid)、得滅克（aldicarb)、亞烈寧（allethrin)、甲 基谷速松（azinphos-methyl)、免敵克（bendiocarb)、免扶克 (benfuracarb)、免速達（bensultap)、畢芬寧（bifenthrin)、布 芬淨（buprofezin)、布嘉信（butocarboxim)、加保利 (carbaryl)、加保扶（carbofuran)、丁基加保扶 (carbosulfan)、培丹（cartap)、可洛斐納皮爾（chlorfenapyr)、 陶斯松（chlorpyrifos)、氯芬松（chloi-fenvinphos)、克福隆 (chlorfluazuron)、可洛西亞尼汀（clothianidin)、可樂馬芬 諾賴德（chromafenozide)、陶斯松-曱基（chl〇rpyrifos-曱 基）、環消蟲菊（cycloprothrin)、赛扶寧（cyfiuthrin)、召-賽 583 314918 200407073 扶寧（冷-cyfluthrin)、賽滅寧（cypermethrin)、賽滅淨 (cyromazine)、賽洛寧（cyhalothrin)、λ -賽洛寧（入_ cyhalothrin)、第滅寧（deltamethrin)、汰芬隆 (diafenthiuron)、大利松（diazinon)、代爾可樂登 (diacloden)、二福隆（diflubenzuron)、二曱基文松 (dimethylvinphos)、代歐芬諾朗（diofenolan)、二硫松 (disulfoton)、大滅松（dimethoate)、因滅丁（emamectin-benzoate)、EPN、益化利（esfenvalerate)、愛芬克 (ethiofencarb)、葉西普羅耳（ethiprole)、依芬寧 (etofenprox)、益多松（etrimfos)、撲滅松（fenitrothion)、丁 基滅乃蚤（fenobucarb)、芬諾克（fenoxycarb)、芬普寧 (fenpropathrin)、芬化利（fenvalerate)、芬普尼（fipronil)、 福祿亞克力匹林（fluacrypyrim)、護賽寧（flucythrinate)、氟 芬隆（flufenoxuron)、福祿芬普洛克斯（flufenpr〇x)、r -福 化利（τ-fluvalinate)、大福松（fonophos)、覆滅 (formetanate)、福木松（formothion)、呋線威（furathiocarb)、 氣酸讲（halofenozide)、六伏隆（hexaflumuron)、愛美松 (hydramethylnon) &gt; 益達胺（imidacloprid)、亞芬松 (isofenphos)、因得克（indoxacarb)、滅必蝨（isoprocarb)、 加福松（isoxathion)、祿芬隆（lufenuron)、馬拉松 (malathion)、四聚乙酸（metaldehyde)、達馬松 (methamidophos)、滅大松（methidathion)、乙丁 烯醯磷 (methacrifos)、美塔爾卡卜（metaicarb)、納乃得 (methomyl)、美錫平（methoprene)、氯化曱醇 314918 584 200407073 (methoxychlor)、美索克西芬諾賴德（meth〇xyferi〇zide)、亞 素靈（monocrotophos)、順-9-二十三烯（muscal ure)、尼狄諾 鐵福朗（nidinotefuran)、尼鐵批朗（nitenpyram)、歐滅松 (omethoate)、滅多松（oxydemeton-methyl)、歐殺滅 (〇乂&amp;111}^1)、巴拉松（93^1:111〇11)、甲基巴拉松（卩3^1:111〇11· methyl)、百滅致（permethrin)、賽達松（phenthoate)、辛硫 石舞（phoxim)、福瑞松（phorate)、裕必松（phosalone)、益滅 松（phosmet)、福賜米松（ph〇sphamidon)、比加普 (pirimicarb)、亞特松（pirimiphos-methyl)、佈飛松 (profenofos)、醚類擬除蟲菊酯（protrifenbute)、派美特羅辛 (pymetrozine)、白克松（pyraclofos)、滅幼寶 (pyriproxyfen)、魚藤酮（r〇tenone)、甲丙硫磷（sulprofos)、 石夕護芬（silafluofen)、賜諾殺（spinosad)、治填峨（sulf〇tep)、 得芬諾（tebfenozide)、得福隆（teflubenzuron)、鐵氟路托林 (tefluthorin)、托福松（terbufos)、四氣文松 (tetrachlorvinphos)、塞蟲琳（thiacloprid)、西亞賽可蘭 (thiocyclam)、硫矽克（thiodicarb)、赛速安（thiamethoxam)、 硫伐隆（thiofanox)、硫滅松（thiometon)、脫耳芬皮拉得 (tolfenpyrad)、特多寧（tralomethrin)、三氯松（trichlorfon)、 托利亞穌隆（triazuron)、三福隆（triflumuron)及繁米松 (vamidothion)等。 實施例 以下’具體說明本發明化合物之合成例及試驗例以做 為實施例，其雖更詳細說明本發明，但本發明並不被其所 314918 585 200407073 局限。 [合成例] 合成例1 1^-[4-[3-(4-氟苯基）-5-三氟曱基_4,5-二氫異噚唑_5_基]_2_ 曱基苯基]-3-硝基-N2-異丙基鄰苯二酸二醯胺（本發明化合 物2-167號） 步驟1 : 4-碘-2-甲基苯胺基曱酸第三丁酯之製造 在4-碘-2-甲基苯胺10.0g之曱笨3〇mi溶液中，添加書 一石反酸二第二丁酯14.0g，並於加熱回流下攪拌2小時。 反應完結後，加水3 0ml並加熱回流i 5分鐘後冷卻至室 溫，然後用l〇〇ml乙醚萃取。將有機層水洗後，用無水硫 酸鎂乾燥，於減壓下餾去溶劑，將殘留之固體用己烷洗淨， 得到為白色結晶之目的物11.5 g。 熔點：101.0 至 103.0°c ^ 2H), 6.22 (bs, 1H NMR (CDC13, Me4Si, 300MHz) (5 7.63 (d, J=8.4Hz, 1H), 7.45.7 1H)· 2.19 (S| 3H), 1.52 (s, 9H).
步驟2:2-曱基-4_(1_三氟甲基乙烯基）笨胺基甲酸第三丁酉旨 之製造 在氮氣環境下’在分散於8〇ml四氫呋喃且用乙酸銀 活性化之辞粉（TetrhedronLeu·, 1981年，22卷，頁） 中’添加2ml之氯三甲基石夕烧並於室溫授拌1〇分鐘， 繼而’加入2-漠-3,3,3-三氟丙烯16.2§及n,n，n,,n，_四甲 基乙二胺22ml，並在6(rc繼續授掉12小時。將沉殿之不 溶物傾析除去後，在反應混合物中添加4_碘_2_甲基苯胺基 314918 586 200407073 甲酉欠弟一 丁西曰i〇.〇g及肆（二苯基膦）|巴l.〇g，並於6〇。〇再 攪拌4小時。反應完結後，於減壓下餾去溶劑，加水2〇〇 ml，並用乙醚萃取（200mlx 2)。將有機層水洗後，用無水 硫酸鎂乾燥，於減壓下餾去溶劑，將殘留物用矽膠管柱層 析（其中使用乙醚溶出）及氧化鋁管柱層析（其中使用乙醚 &gt;谷出）精製，得到為淡黃色結晶之目的物8.4 g。 熔點：8 6 · 0 至 8 8.01： 4Η NMR (CDC13, Me4Si, 300MHz) 6 7.89 (d, J=8.8Hz, 1H), 6.32 (bs, 1H), 5.88 (s. 1H), 5.70 (s, 1H), 1H), 7.29 (d, J=8.8Hz, 1H), 7.24 2.30 (s, 3H), 1.53 (s, 9H). (s, 步驟3.4-[3-(4-氟苯基）-5-三氟甲基-4,5-二氫異噚唑_5_基] -2-甲基苯胺基甲酸第三丁酯之製造 在4-氟苯基醛肟4.lg2N，N_二甲基甲醯胺i〇m丨溶液 中，添加N-氯琥站醯亞胺4.0g，並於室溫攪拌9〇分鐘。 龜而，在該反應混合物中，加入溶於N，N_二甲基甲醯胺1〇 W之2-甲基_4♦三氟甲基乙烯基）苯胺基甲酸第三丁醋 3.〇g及三乙胺3.0g’於室溫再繼續攪拌5〇分鐘。反應完 結後，將反應混合物注入200ml水中，用乙酸乙酿萃取（1〇〇 mix 2) ’將有機層水洗後’用飽和食鹽水及無水硫酸鎂依 次脫水’乾燥及於減壓下餾去溶劑，將殘留固體用矽膠管 柱層析（其中使用乙酸乙醋·己燒（8: ^溶出）精冑，得到為 白色結晶之目的物3.3g。
熔點：149.0 至 150.0°C JH), 7.65-7.7 (ni, 2H), 7.41 (s. 1H), (s，1H)，4.02 (d, &gt;17. ihZt 1H), 3.70 !H NM (CDC13, Me4Si, 300MHz) 5 7.95 (d, J=8.7Hz, 7.36 (d, J=8.7Hz, 1H), 7.05-7.15 (m 2H), 6.33 (d. M7. 1Hz, 1H), 2.28 (s, 3H), 1.52 (s, 9H). 334918 587 200407073 V驟4·4-[3_(4_氟苯基三氟曱基_4,5_二氫異嗜。坐_5_基 -2-甲基苯胺之製造 土 在4_[3-(4-氟苯基）-5-三氟甲基_4,5·二氫異嗜嗤基] -2-甲基苯胺基甲酸第三丁酯2 6g中，於冰冷攪拌下，滴 入三氟乙酸1 〇ml。在同溫度下，繼續攪拌i 〇分鐘後，於 減壓下鶴去溶劑，在殘留之油狀物質中加入乙醚1〇〇如， 然後用飽和碳酸氫鈉水溶液i 00ml洗淨。分取有機層後， 將水層用乙醚萃取（100mlx 2)，合併有機層及用飽和碳酸 氫鈉水溶液1 00ml洗淨後，用飽和食鹽水及無水硫酸鎂依 次脫水，乾燥及於減壓下餾去溶劑，將殘留固體用矽膠管 柱層析（其中使用乙酸乙酯-己烷（1 : 3)溶出）精製，得到為 白色結晶之目的物1.7 g。 熔點：108.5 至 lio.〇。〇 'H NMR (CDC13, Me4Si, 300MHz) &lt;5 7.6-7.7 (m, 2H), 7.2-7.3 (a 2H), 7.05-7.15 (in, 2H) 6-68 (d, 1=8.4Hz, 1H), 3.98 (d, J=17. 1Hz, 1H), 3.69 (d, 1=17. 1Hz, 1H), 3 72 (bs 2.18 (s. 3H). · D’ 步驟5 : N-[4-[3-(4-氟苯基）-5-三氟曱基_4,5-二氫異噚唑_ 5-基]-2 -曱基苯基]-3-硝基酞醯亞胺之製造 將3-硝基酞酸酐〇.84g及4-[3-(4-氟苯基）-5-三氟曱基 二氫異噚唑基]_2_曱基苯胺118g之乙酸^…溶 液，於1 00 C攪拌5小時。反應完結後，於減壓下餾去溶 劑，將殘留之固體用乙醚洗淨，得到為白色結晶之目的物 1.5 4 g 〇
熔點：221.0 至 222.0°C 314918 588 200407073 δ8'15'8·25 2Η)·8·00 (t· μ·8ηζ· ιη)· 7·65-7·7 ^ m \o ( J ,7 η' H !d，J=8'4Hz，1H)，U~7·15 k 2H)' 410 (d' J=17-1Hz' lH)f 3.70 (d, J=17. 1Hz, 1H), 2.27 (s, 3H). 步驟6 : NM4-[3-(4-氟苯基）_5_三氟甲基_4,5_二氫異噚唑_ 5-基]-2-曱基苯基]-N2-異丙基-3-硝基鄰苯二酸二醯胺之製 造 將N-[4-[3-(4-氟苯基）-5-三氟甲基_4,5-二氫異噚唑-5_ 基]-2 -曱基苯基]-3-硝基駄醯亞胺！47§之14-二嗜烧2〇ml 溶液中，添加異丙胺l5g，並於室溫攪拌18小時。反應 完結後，於減壓下餾去溶劑，將殘留之固體用乙醚洗淨， 付到為米色結晶之目的物1.4 2 g。 溶點：1 5 2 · 0 至 1 5 3 · 0。〇 HNMR (CDCl, Me4Si, 300MHz) 6 9.89 (s, 1H), 8.41 (d, J=7.8Hz, 1H), 8.17 (d, J=7.8Hz 8.00 (d, M.5Hz, 1H), 7.75-7.85 (m 2H), 7.75 (t, J=7.8Hz, 1H), 7.61 (d, 1H), 7.46 (s, 1H), 7.43 (d, J=8.7Hz, lH), 7.3-7.35 (m 2H), 4.34 (d, J=18. 0Hz, 1H), 4.15 (d, J=18.0Hz, 1H), 3.85-3.95 (¾ iffi, 2.32 (sf 3H), 1.02 (d J=6. 6Hz，6H). 合成例2 3_胺基-氟苯基）-5-三氟曱基-4,5_二氫異曙唑_ 5-基；1-2 -甲基苯基]異丙基鄰笨二酸二醯胺（本發明化合 物2-170號） 在N】-[4-[3-(4 -氟苯基）-；5-三氟甲基二氫異口等哇_ 5基]-2·»甲基苯基]_n2-異丙基-3-硝基鄰苯二酸二酸胺（本 發明化合物2-167號）l.3〇g之曱醇25ml溶液中，添加5% 活性碳載持之鈀〇. 1 lg，並於常溫、常壓及氫氣環境下攪 掉2.5小時。反應完結後，將不溶物用矽藻土過攄，於減 314918 589 200407073
壓下餾去溶劑，將得到之固體用矽膠管柱層析（其中使用乙 酸乙酯溶出）精製，得到為淡黃色結晶之目的物119§。 熔點：122.0 至 124.0°C lHNMR (CDC13, Me4Si, 300MHz) 5 8.25 (d, J=8. 1Hz, 1H), 7.65-7.7 2H) 7 56 (s im 7.4-7.45 (π, 2H), 7.15-7.3 to, 1H), 7.1-7.15 (a 2H), 6.95 (d, J=7.2Hz： 6 81 d J=7.2Hz, 1H), 6.19 (d, J=8.1Hz, 1H), 4.62 (bs, 2H), 4.05^4.2 (ο, 1H) 4.05 (' ί=17.1Ηζ, 1H), 3.73 (d, J=17. 1Hz, 1H), 2.30 (s, 3H), 1. 〇6 (d, J=6.6Hz, * ， 合成例3
Nl-[4-[3-(4 -氟苯基）-5-三氟曱基二氫異噚哇基]_2_ 甲基苯基]-3-碘-N2-異丙基鄰苯二酸二醯胺（本發明化合物 2-016 號） 在3-胺基-N1-[4-[3-(4-氟苯基）-5-三氟甲基-4,5_二氫 異噚唑-5-基]-2-甲基苯基]-N2-異丙基鄰苯二酸二醯胺（本 發明化合物2-170號）l.〇2g之乙酸13ml溶液中，於冰冷攪 拌下，添加濃硫酸0 · 5 5 g，繼而將亞硝酸鈉〇 ·丨3 g溶於〇 · 5 水之/合液，以不使反應混合物之溫度超過丨5艺之速度滴 下。滴下終了後，於相同溫度繼續攪拌2〇分鐘後，將其經 25为知滴入保持在4〇它之碘化鉀〇·3%溶於水之溶 液舁氯仿40ml之混合物中，然後於4(^c繼續攪拌5〇分 1里反應完結後，分取有機層，用硫代硫酸鈉水溶液1⑼— 洗平，用飽和食鹽水及無水硫酸鈉依次脫水，乾燥及於減 壓I餾去溶劑，將殘留固體用矽膠管柱層析（其中使用乙酸 乙自曰-己烷（1 : 3)溶出）精製，得到為白色固體之目的物 0.5 6 g 〇 炼點·· 1 2 8 · 0 至 1 3 0. 〇 °c 314918 590 200407073 41 NMR (CDC13. Me4Si, 300MHz) ό8·46 un 1.2Hz, 1H), 7.73 (d, 1=7.2Hz, 1H), 7 7 * 8*〇〇 (d，i=8* ^ 1H)，94 (dd，，=8* 1»，7.05-7.2 (n 3H), 6.04 (d 卜8 1H ·7 紅 2H), 7·45 (S，鼠 7.40 (d，M4Hz， u73 歲m, 2 35 拙，4卜43机丨^仍w，卜划z, （s，3H), ι·ι6 (d，j=6.6Hz, 6H)· 合成例4 3-碘-N2-異丙基-NL[2-甲基一 4 三氟 4 氨異曙哇-5·基）苯基]鄰笨二酸二㈣（本發明化:物丄侧 號）及6-峨-N2-異丙基_N1_[2_甲基_4_(3_甲基_5_三氣甲基- 4,5-二氫異曙唾-5_基）苯基]鄰笨：酸二㈣（本發明化合 物1-007號） 步驟1 : 2-曱基-4-(3-甲A &lt;： P甲基-5-三氟甲基_4,5_二氫異噚唑巧一 基）笨胺基甲酸第三丁酿之製造 在乙醛肟0.5g之NN - m社扣士 ，N —曱基甲胺30ml溶液中，添 加N-氯琥珀酸醯亞胺1 1 妝i.lg，並於室溫攪拌30分鐘。繼而， 在該反應混合物中加人合成们之步驟i至步驟2中合成 之2-:甲基_4·(1•三氣甲基乙烯基）笨胺基甲酸第三丁醋 及三乙胺0 · 8 g，並於室消旦繼滅 1 至，凰再龜績攪拌5小時。反應完結後， 將反應混合物注入20〇m〗火由 m ^ ^ 尺中’用乙喊卒取（l〇〇mi&gt;&lt;2)， 將有機層用水洗後，用益★ Z六紗1 As/ , …、水&amp;I鎂乾燥，並於減壓下餾去 &gt;谷劑。將殘留固體用石夕膠管才声才 C g狂信析（其中使用乙醚溶出）及 氧化紹管柱層析（其中# 7 V、甲使用乙醚〉谷出）精製，得到為淡黃色 結晶之目的物〇.9g。 步驟2: 2 -曱基- 4- (3 -曱美$二ϋ田甘 V T I·5·二鼠甲基U-二氫異噚唑- 5_ 基）苯胺之製造 在2_曱基-4-(3·甲基士三氟甲基_4,5_二氫異噚。坐_5_ 314918 591 200407073 基)本胺基甲酸弟二丁酯中’於冰冷攪拌下，滴入三 氟乙酸^。於室溫繼續授拌Μ分鐘後，於減壓下館去溶 ^!，得到為褐色油狀物質之粗製目的物Q 8g。其可在未精 衣下用於接下來之反應。 步驟3 : 3-峨也異丙基银[2_甲基_4_(3_甲基_5-三氣 -4,5-二氫異^坐_5·基）苯基]鄰苯二酸二酿胺及6_硬抓^ 丙基-NM2-曱基·4_(3_甲基_5_三氟甲基二氫異噚唑_ 5一基）苯基]鄰苯二酸二醯胺之製造 在3碘-丙基酞醯胺酸l.〇g之甲苯10ml溶液中 於室溫攪拌下，滴入三氧乙酸針1〇g。在同溫度下檀拌 分鐘後，於減壓下德去溶劑，將殘留之黃色油狀 :氯咲喃胸.中，添加粗製之2_甲基_4·(3·甲〜；： 基'5-二氫異嘻唾_5_基)笨胺〇8g，並於室溫：甲 :時：反應完結後，於減壓下顧去溶劑，將殘留之固t 膠“主層析(其中使用乙酸乙酯 '氯·：用 :別得到—異丙基卿_甲基邻 =5-二氫異^坐_5_基）苯基]鄰笨二酸二酿胺之白^士甲 =.45g m_N2_異丙基机[2_甲基_4七_甲基_二 土-4,5-一氫異噚唑_5-基）笨 一氟 結晶。.35g。 ）本基]鄰笨二酸二驢胺之白色 3，|-異丙基机[2-甲基冰（ 氣異嗜哇-5·基）苯基]鄰苯二酸二驢ς…二氣甲基乂 5、二
4 點·· 236.0 至 238.CTC 314918 592 200407073 丨}1讎（CDCU Meji，300MHz) (5 8.39 (bs, IH)，8.10 (d, J=8.5Hz，1Η), 7· 96 (d J=8.0Hz, 1H), 7./9 (d, J=8.5Hz, 1H), 7.1-7.4 (m, 3H), 5.87 (d, J-8.0Hz, 1H), 4.1-4.3 (m, 1H), 3.64 (d, J-17. 6Hz, 1H), 3.32 (d, J=17. 6Hz, 1H), 2.34 (s, 3H), 2.02 (s 3H) 1. 17 (d, J=6.3Hz，6H).
6-碘-N2-異丙基-Ν1-。-甲基-4气3-甲基巧_三氟甲基_4,5_二 氫異曙峻-5-基）苯基]鄰苯二酸二醯胺 溶點：186.0 至 188.0°C iH 醒（CDC13，Me4Si. 300MHz) δ?·98 (bs，1Η)，7·92 (d, J=8.3Hz，1H)，7·79 (d J=7.5Hz, 1H), 6.9-7.4 (m, 4H)f 6.52 (d, J=6.0Hz, 1H), 3.9-4.2 (m, IH) 3 58 (d J=17.6Hz，1H)，3.26 (d，J=R6Hz，1H)，2·27 (s，3H), 1·95 (s，3H)，L03 (d J:66Hz’ 6H). ’ 合成例5 &gt;11-[4-[3-(4-氯苯基）-5-三氟曱基_4,5_二氫異噚唑_5_基]_2_ 甲基苯基]-3-碘-N2-(l-甲基_2_甲硫乙基）鄰苯二酸二醯胺 (本發明化合物2-095號） 步驟1 : 4-氯苯基異羥肟酸氣化物之製造 在4-氯苯基醛肟〇.46g之二噚烷8ml溶液中，加 入濃鹽酸4ml，冰冷攪拌下，經1〇分鐘滴入8%次亞氯酸 鈉水溶液3.0g。滴下終了後，於同溫度繼續攪拌ι〇分鐘 後，加入水30ml，然後再攪拌3〇分鐘。反應完結後，將 生成之固體濾出及水洗（3Omlx 2)，於減壓下乾燥，得到為 白色結晶之目的物0.4g。
熔點：86.0 至 87.0°C iHNMR OU3, Me4Si, 3_ΗΖΗ8·00 (s，1H)，7,75_7 85 (取 2H) 7 35_u〇 (肛 2h) 步驟2: 4-[3-(4-氯苯基）-5-三氟曱基_4,5_二氫異噚唑_5_基] -2-曱基苯胺曱酸第三丁酯之製造 314918 593 200407073 在用合成例1之步驟丨至步驟2合成之2•甲基_心（^ 二氟甲基乙烯基）苯胺基甲酸第三丁酯3. 〇§之”^^ 一曱美 甲fe胺25ml溶液中，添加4_氣苯基異羥聘酸氯化物 2 · 3 3 g ’然後於冰冷攪拌下，經i 〇分鐘滴入三乙胺&amp; 2 。 於室溫繼續攪拌5小時後，將反應混合物注入工〇〇ml水 中，用乙酸乙酯萃取（l00mlx 2)，將有機層用水洗後，用 無水硫酸鎂乾燥，並於減壓下餾去溶劑。將殘留物用矽膠 管柱層析（其中使用乙酸乙酯-己烷（1 :丨）溶出）精製，得到 為白色結晶之目的物4.2g。 Ή 麵（CDC13, Me4Si，300MHz&gt; 5 7.95 (s，1H)，7.5-7.6 (in，2H), 7.3-7·4 (in,做 6 33 (bs，1Η)，3.99 (d，；Ν6·8Ηζ，1Η)，3· 68 (d，J=17.4Hz，1Η)，2,28 (s, 3Η), U2 (s，9Η) 步驟3: 4-[3-(4-氣苯基）-5-三氟甲基-4,5-二氫異噚唑-5_基] -2-甲基苯胺之製造 在4-[3-(4 -氯苯基）-:5-三氟曱基-4,5-二氫異曙唾基] -2-曱基笨胺甲酸第三丁酯3 2g中，於冰冷攪拌下，滴入 三氟乙酸15ml。在同溫度下，繼續攪拌1 〇分鐘後，於減 壓下餾去溶劑，在殘留之油狀物質中加入乙醚1 〇〇ml，然 後用飽和碳酸氫鈉水溶液1 〇〇ml洗淨。分取有機層後，將 水層用乙醚萃取（l〇〇mlX 2)，合併有機層並用飽和碳酸氫 納水溶液1 〇〇ml洗淨後，用飽和食鹽水及無水硫酸鎂依次 脫水，乾燥及於減壓下餾去溶劑，將殘留固體用石夕膠管柱 層析（其中使用乙酸乙酯-己烷（1 : 3)溶出）精製，得到為白 色結晶之目的物1.9 g。 熔點：117.5 至 1 19.0X： 314918 594 200407073 iHNMR _3, Me汍 30_ δ7•抑.65 (取 7.22 (d，&gt;8. 1Hz，1Η&gt;，6.69 (d，J=8 他 lm Qn (，，7·25 (s，1Η)， J=17.4Hz, 1H), 3.73 (b, 2H). 2.18 (s 3H). 97 1H)' ^-69 (, 步驟4 : ^-[4-[3-(4-氣笨基二蠢 ；一虱曱基_4,5-二氫異嗜唑· 5-基]-2 -曱基苯基]-3-蛾一 n2-(i_曱美？田六 Τ基-2-曱石瓜乙基）鄰笨二 二醯胺之製造 在3 -峨-N-(l -曱基-2-甲石六计 ^ Τ石爪基乙基）酞醯胺酸〇.3g之二 氯甲烧4ml溶液中，於冰冷擔牲 ^ 視件下，加入吡啶〇12ml及三 氟乙酸酐0.1 8g，並於同溫度下擔 一 反卜攪拌2小時。繼而添加4_ [3-(4 -氯苯基）-5-三氟曱基^ ^ ^ 一虱異％唑-5-基]-2-甲基 苯胺0.28g，並於室溫繼續攪採 ^ ^ 土 只視件12小時。反應完結後，將 反應混合物注入1Gml水中，用氣仿萃取（lOmlx 2)，將有 機層用水洗後’用無水硫酸鎂乾燥，於減壓下餾去溶劑。 將殘留固體用石夕膠管柱層析(其中使用乙酸乙醋_己烷⑴ 溶出）精製，得到為白色結晶之目的物〇 Ug。
溶點：11 6.5 至 1 2 0 · 3 °C ή 1ΝΜΚ (CDCl, 7Qfi M (d* J=2*1HZ^ 1H)&gt; 8*22 (dd&gt; J=8·^ UHz, IH) • ' J~7.5Hz, 1H), 7.77 (d, J=7.8Hz, 1H) 7 55-7 65 (m 2H) 7 u 7 r 7. 20 (t 1=¾ iH7 im r οι μ τη n/，（.Mb5(nU)，7.35-7.5(in,4H) 通 /7() (d，M1HZ，1H)，4·25一4.35 (m，1H). 4.04 W, J=17.1Hz j 25 (, d，J=I?*4HZ，1HK 2·5~2*65 (ln* 2H), 2.36 (s, 3H), 1.91 (d, J=i. 8Ηζ 3H) L2i) W, J=6.6Hz, 3H). ^Η) 合成例6 N，N2-二乙基-3-碘_Ν]·[4_[3-(4_甲磺醯苯基卜5·三氟曱基- 4,5-_氫異噚唑基曱基苯基]鄰苯二酸二醯胺（本發 明化合物2-162號） 步驟1 : 3-碘-Ν，Ν-二乙基酞醯胺酸之製造 595 314918 200407073 在3-碘酞酸酐2.0g之乙腈溶液中，於冰冷攪拌 下，滴入0.7g二乙胺，滴入終了後於室溫攪拌2小時。反 應完結後，將析出之固體濾出，用少量乙腈洗淨，得到為 淡黃色結晶之目的物l.5g。
熔點：120.0 至 122.0°C
iH 酿（CDC13, Me4Si，300MHz) 5 8.28 (bs, 1H), 8.05 (d, J=8 5H j=8.5Hz, 1H), 7.0-7.2 (m, 1H), 3.67 (q, J=7. 2Hz, 2H), 3.49 (Q m) \ 19(d； j=：7. 2Hz, 3H), 1.10 (t, J=7.2Hz, 3H). ’ ，贩 2H)，1· 12 (t， 步驟2 : N2，NL二乙基-3-峨抓[心[M4_甲磺醯苯基三 氟甲基_4,5_二氫異卩萼唾-5-基]-2•曱基苯基]鄰苯二酸二醯 胺之製造 在3-碘-N，N-二乙基酞醯胺酸〇 5g之氯仿η—溶液 中，加入1 ·Og亞硫醯氣，並於加熱回流下攪拌*小時。反 應完結後減壓下館去溶劑’將殘留物溶於1 〇瓜1乙睛中 添加以與合成例5之步驟1至步驟2闾样丄 一 / μ z IJ铋之方法從4-曱基 石黃醯本备月5合成之4-[3-(4 -甲石黃酿苯基）·$_二氟甲美4 二氫異.坐-5-基]-2-曱基苯胺。·5 g，並於：：授；_::;: 時。反應完結後，濾出析出之固體，用少 J /里乙腈洗淨，得 到為白色結晶之目的物0.2g。 熔點：155.0 至 157.0^ •HNMR (CDC13, Me4Si, 300MHz) (5 8.19 (d, 1=8.6Hz, 1H) 8 01 J=8.6Hz， 1H), 7.88 (d，J-8.2Hz, 2H), 7.64 (bs 1H) . 7 丨，J=8.2Hz，2H), 7.93 吐 j = 17.3Hz，1H&gt;，3·77 (d，J = 17.3HZ，iH)，3.46 (Q，]Hz 2H)〜7. 5 (Π1，猶，4.08 (d， 3.07 (s，3H)，2.41 (s，3H)，L05 (t，J=7. 1Hz 刻 1 〇4 “ ’τ ·19 (Q，2H)， ，n/，1肩（t，H. 1Hz，3H). 合成例7 N] [4-[3-(4-胺曱醯苯基）-5-三氟曱基·4,5 氫異噚唑-5- 314918 596 200407073 基]-2 -甲基苯基]-3-峨-&gt;12_異丙基鄰苯二酸二酿胺（本發明 化合物2-048號） 在心-[4-[3-(4·氰基苯基）_5-三氣甲基-4,5-二氫異嗜唉 -5-基]-2 -甲基苯基]-3-埃-N2-異丙基鄰苯二酸二醯胺（本發 明化合物2-046號）〇.22g之二甲基亞楓iml溶液中，加入 無水碳酸鉀0.14g，繼而於室溫及攪拌下滴入35%過氧化 氮水洛液0 · 11 g，滴入終了後’於同溫度繼續再攪拌1小 時。反應完結後，將反應混合物用水5ml稀釋，並用5mi 乙酸乙酯萃取。將有機層用無水硫酸鈉乾燥，於減壓下顧 去溶劑’得到為淡黃色玻璃狀固體之目的物Q . 1 2 g。
熔點：173.0 至 175.0°C WNMR _3, Me4Si，3_ζ) δ9.59 (bs，1H), 8 7〇 (bs，1H)，U2 (d J=84Hz ih) 7j8.0ta，3ro，7.H85(m，3H&gt;，7.44(bs,2H)，72〇(t，〗=8〇Hz，1H&gt;w^ J=8.4Hz, 1H), 6.07 (bs, 1H), 4.15-4 25 (m, 1H), 4.09 (d, 1=17.2Hz, 1H) 3 79 (d J=17.2Hz, 1H), 3.00 (Sr 3H), 1.15 (d, J=6.8Hz, 6H). 合成例8 3-蛾-N2-異丙基-Nw[3-(4-曱基亞磺醯苯基卜5-三氟甲基_ 4,5-二氫異％唑-5-基]-2-曱基笨基]鄰苯二酸二醯胺（本發 明化合物2-037號） 步驟1:2-甲基-4-[3-(4-曱硫基笨基）-5-三氟曱基_4,5-二氫 異Π号唑-5 -基]苯胺甲酸第三丁酯之製造 在合成例1之步驟1至步驟3中合成之‘[3_(扣氟苯 基）-5-三氟曱基-4,5-二氫異β萼唑-5·基]-甲基苯胺曱酸第 二丁酷2.0g之Ν，Ν-二曱基甲醯胺5〇ml溶液中，添加硫代 曱氧化鈉l.〇g，並於室溫攪拌15小時。反應完結後，用 597 314918 200407073 乙酸乙酯100ml稀釋及水洗（l〇〇mlx 2)，將有機層用飽和 食鹽水及無水硫酸鎂依次脫水、乾燥並於減壓下餾去溶 劑。將殘留物用二異丙醚-己烷混合溶液結晶，得到為白色 結晶之目的物2.0g。
熔點：147.0 至 149.CTC 'HNMR (CDC13, Me4Si, 300MHz) 5 7.95 (d, J=8.5Hz, 1H), 7.57 (d, J=8.5Hz, 2H), 7.42 (s, 1H), 7.36 (d, J=8.5Hz, 1H), 7.24 (d, J=8.5Hz, 2H), 6.33 (bs, 1H), 4.02 (d, J=17. 〇Hz, 1H), 3.70 (d, J=17.0Hz, 1H), 2.50 (st 3H), 2.28 (s, 3H), 1.52 (s, 9H). · 步驟2 : 2 -甲基- 4- [3-(4 -曱基亞石黃醯苯基）-5_三氟甲基 二氫異卩琴唑-5-基]苯胺甲酸第三丁酯之製造 在2_甲基_4-[3-(4-甲硫基苯基）-5-三氟甲基_4,5_二氫 異噚唑-5-基]苯胺甲酸第三丁酯1〇g之二氯甲烷5〇mi溶液 中’於冰冷攪拌下，添加3-氣過苯曱酸〇·5 7g，並於同溫 度攪拌15分鐘。反應完結後，將反應混合物用飽和碳酸氫 鈉水溶液洗淨（30mlx 3)，將有機層用飽和食鹽水及無水硫 酸鎂依次脫水、乾燥並於減壓下餾去溶劑。將殘留物用分 取液體層析（乙腈：水=4: υ精製，得到為玻璃狀固體之目 的物0.9g。 熔點：76.5 至 88.5t： -Τ&quot;；： m'184 (d' J=8-5HZ'2ro·7·40 ^ 步穌3如2-甲基曱基亞石黃醯苯基）_5•三氣甲基-4,5_ 二氫異嘿唑-5-基]笨胺之製造 尸ΐ ^甲基-4-[3-(4_甲基亞磺醯苯基）-5-三氟曱基_4,5_ 一虱兴％唑-5-基]苯胺甲酸第三丁酯〇 4g中，於室溫攪拌 314918 598 200407073 下，滴入三氟乙酸2ml。於同溫度繼續攪拌3 〇分鐘後，於 減壓下餘去溶劑，將殘留物溶於乙酸乙酯5 〇ml中，並用 飽和碳酸氫鈉水溶液3Oml洗淨。將有機層用飽和食鹽水 及然水硫酸鎂依次脫水及乾燥後，於減壓下餾去溶劑，得 到為淡黃色玻璃狀固體之粗製目的物〇 9g。其可在未精製 下用於下一反應。
熔點·· 68.5 至 77.0°C 7.69 (d, J=8.5Hz, 2H), 7.26 (s, 4.03 (d, 1=17. OHz, 1H), 3.7-3.8 Ή 麵（CDC13, Me4Si，30_z) 5 7.83 (d，J=8.5Hz 2H) 1H). 7.23 (d, J=8.2Hz, 1H), 6.67 (d, J=8. 2Hz 1H) (m，3H), 2.74 (s，3H)，2· ]9 (s，3H). ，’ 步驟4: 3务N2•異丙基抓[2•甲基_4例心甲基亞礦酿苯 基）-5-三氟甲基_4,5_二氫㈣哇_5_基]苯基]鄰苯二酸二醯 胺之製造 开叼丞陬釅胺酸〇.3g 於室溫攪拌下，滴入二# /合欣t ’ 滴一鼠乙酸酐0·23§。於同溫度繼續攪 二鐘後，於減厂堅下館去溶劑，將殘留之黃色油狀物 中，加入2_甲基邻-(”基亞續酿苯基)-土 4,5-一虱異噚唑_5_基]苯胺〇. 績攪拌5小時。反庫—紝 方、至皿％ 之固體_管=:= 館去溶劑，_ 為白色玻璃狀固體之目的物〇.4g。 付到 炫點：134.0 至 151.5t 314918 599 200407073 !OMR (CDC13，Me4Si，300MHZ) δ8.45 (s, 1H)，8. 16 (d，J=8」Hz，1Η)，7·96 (d，J=7.8Hz, 1H), 7.85 (d, J=8.7Hz, 2H), 7.79 (d, M. 8Hz, 1H), 7.70 (d, 1=8.7Hz, 2H), 7.46 (s, * 1H). 7.42 (d, J=8. 1Hz, iH), 7. 20 (t, J=7.8Hz, 1H), 5.95 (d, M. 8Hz, 1H), 4. 1-4.3 (in, 1H), 4.09 (d, J=17. 1Hz, 1H), 3.78 (dt J-17. 1Hz, 1H), 2.74 (s, 3H), 2.37 (s, 3H)/ 1.17 (d, J=6.6Hz, 6H). ’ 合成例9 3-破-&gt;12-異丙基_^1-[2-甲基-4-(3,5-雙三氟甲基-4,5-二氫異 口琴嗤_5-基）苯基]鄰笨二酸二醯胺（本發明化合物i_〇13號） 步驟1 : 2 -甲基-4-(1-三氟甲基乙烯基）苯胺之製造 在合成例1之步驟1至步驟2中合成之2-曱基-4-(1 _ 三敗曱基乙烯基）苯胺甲酸第三丁酯l.5g中，於冰冷攪拌 下’滴入三氟乙酸5ml。於室溫繼續攪拌1 〇分鐘後，於減 壓下鶴去溶劑，得到為褐色油狀物質之粗製目的物1 · 3 g。 其可在未精製下用於下一反應。 步驟2 : 3&quot;'峨-N2-異丙基-N2-[2-甲基-4-(1-三氟甲基乙烯基） 苯基]鄰苯二酸二醯胺之製造 在峨-N-異丙基酞醯胺酸2.0g之甲苯30ml溶液中， 於室溫攪拌下，滴入三氟乙酸酐i 8g。在同溫度攪拌3〇 ^ ^後’於減壓下餾去溶劑，將殘留之黃色物質溶於30ml 之四氫呋喃中，然後添加粗製之2-甲基-4-(卜三氟甲基乙 烯基）苯胺1.2g，並於室溫繼續攪拌5小時。反應完結後， 於減壓下餾去溶劑，將殘留之固體用矽膠管柱層析（用乙酸 -曰氯仿（1 · 9)溶出）精製，得到為白色結晶之目的物 2.2g。
炫點：20】·〇至203.(TC 3149]8 600 200407073 IH 職（CDC丨3, Me4Si，3_ζ) ό8.37 (bs，m)，8.丨〇 (d, j=請 】=6.9Hz，1H)，7·79 (d，J=6.0Hz，]H) 7 l-7 4 ’ H，7.96 ^ 1H) ς im z η h 7.1 7.4 (ία 3H), 5.92 (s, 1H), 5.88 (d, J=6.0Hz, ).5.76 (s, 1H), 4.1-4.3 (m, lH), 2.34 (S| 3H)&gt; j ]=6 ^ 步驟3 : 3-碘-N2·異丙基_nl[2_甲基-4_(3,5-雙三氟曱基_ 4,5-二氫異噚唑-5-基）苯基]鄰苯二酸二醯胺之製造 在2,2,2-三氟乙醛肟！ 〇g之二甲氧乙烷Μ—溶 液中，添加N-氯琥珀醯亞胺1〇g，並於4〇t：攪拌i小時。 繼而，在該反應混合物中，加入弘碘-N2_異丙基_N]_[2-甲 基1(1 _二氟曱基乙烯基）笨基]鄰苯二酸二醯胺i 〇g，碳酸 氫鉀6.0g及1滴水，並於室溫再繼續攪拌5小時。反應完 結後，於減壓下餾去溶劑，在殘留物中加入水2〇〇mi ^用 氯仿萃取（lOOmlx 2)，將有機層水洗後，用無水硫酸鎂乾 燥，於減壓下餾去溶劑，將殘留固體用矽膠管柱層析（其中 用乙酸乙酯-氯仿（1 : 9)溶出）精製，得到為白色結晶之目的 物 0 · 4 2 g 〇 熔點
24υ·υ JL 242.0 C iH 醒（叫 _· 3_) &lt;5 8·44 (bs, 1Η). 8 21 J=6.9Hz, 1H), 7.78 (d, J=6.0Hz, 1H), 7.1-7 5 (m ^H) Ron m ； ' (' 1=12.4H, 1H), 4.18 (d, M2.4Hz, 1H), 2.37 (s 3 ) 1 1 ( \ Γ'^ K 训，1·16 (d, Η·6Ηζ, 6H) 合成例10 · 乙氧羰基·5_三 甲基苯基卜6-蛾-Ν2-異丙 1-020 號） 氟曱基-4,5-二氫異噚唑_5_基）_2_ 基鄰苯二酸二醯胺（本發明化合物 烯基）苯基]酞醯 步驟1 : 3-碘-Ν-[2-甲基-4·(1-三氟曱基乙 亞胺之製造 中合成 將在合成例9之步驟 之甲基-三氟曱 314918 60] 200407073 基乙烯基）苯胺1.6g及3-碘酞酸酐2.2g之乙酸30ml溶液， 於加熱回流下攪拌2小時。反應完結後，於減壓下餾去溶 劑，將殘留物用矽膠管柱層析（用乙酸乙酯-己烷（3 : 7)溶出） 精製，得到為白色結晶之目的物2.8g。
熔點：143.0 至 145.0°C lH NMR (CDC13, Me4Si, 300MHz) 0 8.20 (d, J=9.0Hz, 1H), 7.96 (d, J=9.0Hz, 1H), 7.2-7 6 (¾ 4H), 6.02 (s，1H), 5.83 (s，1H)，2.24 (s, 3H). ’ · 步驟2 : N-[4-(3-乙氧羰基-5-三氟甲基-4,5-二氫異卩琴唑_ 基）_2 -曱基苯基]_3_埃献酿亞胺之製造 在3-碘[2-甲基-4-(1-三氟曱基乙烯基）苯基]酞醯亞 胺0.8g及2-氯-2-羥亞胺乙酸乙酯〇.4g之1，2_二甲氧乙烧 4 0 m 1 ’谷液中’加入碳酸氫鉀3 · 〇 g及1滴水，並於室溫授 拌1 8小b守。反應元結後於減壓下鶴去溶劑，在殘留物中加 入水100ml並用乙酸乙酯萃取（1〇〇mlx 2)，將有機層用飽 和食鹽水及無水硫酸鈉依次脫水及乾燥後，於減壓下餾去 溶劑。將殘留固體用矽膠管柱層析（用乙酸乙酯-己烷（3: 7) 冷出）精製，得到為白色結晶之目的物〇.45g。 乂驟3.1^-[4-(3-乙氧羰基_5-三氟甲基_4,5_二氫異_唑巧 基）-2-甲基苯基]_6_峨，2_異丙基鄰苯二酸二醯胺之製造 在N [4 (3乙氧罗厌基_5_三氣甲基_4,5_二氮異曙口坐 )甲基苯基]-3-峨敢酿亞胺〇45§之二噚烷“Μ 溶液中，添加異丙胺2·0Π11’並於室溫攪拌3日。反應完 結後，於減壓下館去溶劑，將殘留固體用石夕膠管柱層析(用 乙酸乙雖-氣仿（3 : 7)溶出）精製，得到為白色結晶之目的 314918 602 200407073 物 0·26 g 〇 熔點：172.0 至 174.0°C 1議（叫，Me4Si, 3_ΖΗ8·㈣.J=6.5Hz，1H), 7 (bs, ,H), ,53 (d. M.OH, 1H), ,1-,4 „ 3H,. , 40 (d, J=, 7Hz, ]H). , 36 (q M.2Hz, 2H), 4.0-4.2 (, 1H). ,95 (d, J=1, 5Hz, 1R) 3 ^ ^ (s, 3H), 1.21 (t, J=7. 2Hz, 3H), 1.11 (d, J=6.6Hz, 6H) 合成例1 1 3-蛾-N2-異丙基-NM4-[3-(l，2,4-三唑+基）_5_三氟甲基_ 4,5-二氫異噚唑-5-基]-2-曱基苯基]鄰苯二酸二醯胺之製造 (本發明化合物1-032號） 步驟1 : 4-(3-氯-5-三氟甲基-4,5_二氫異嗜唑基）甲基 苯胺曱酸第三丁酯之製造 得到 在經亞胺乙酸5.0g2 12-二甲氧乙烷8〇mi溶液中， 添加N-氣琥珀醯亞胺15.0g，並於75t攪拌i小時。將反 應混合物冷卻至室溫後，加入在合成例丨之步驟丨至步驟 2中合成之2-曱基-4-(1-三氟甲基乙烯基）苯胺曱酸第三丁 醋3.0g及碳酸氮钟20.0g，於室溫下，繼續再攪拌18小時 反應完結後’於減壓下館去溶劑’加入氯仿5〇mi並濟出 不溶物，將氣仿層用iN鹽酸洗淨後，用飽和食睡水及| 水硫酸納依次脫水及乾燥後，於減壓下德去溶劑二 二 固體用矽膠管柱層析（用氯仿-己烷（4: 6)溶出）精製，、虼留 為白色結晶之目的物1.18 g 〇 月 ’
熔點：83.0 至 85.0°C SHNMR (CDC13, Me4Si, 300ΜΗζ) δ 7.97 (d, H. 5Hz 1H) 7 ” 3.83 (d，P17.5Hz，1H)，3.55 (d，J=n. 5Hz，1H)，2 28 (s m 加，细，&amp; 34 (bs，1H) * ’ ，1，53 (s，9H&gt;· 314918 603 200407073 步驟2 : 2-甲基-4-[3-(l，2,4-三唑-1-基）-5-三氟曱基-4,5-二 氫異_唑-5-基]笨胺曱酸第三丁酯之製造 在1，2,4-三唑〇.23g之n，N-二甲基甲醯胺20ml溶液 中’添加60%油性氫化鈉0.13g，並於室溫攪拌15分鐘。 氫氣之產生停止後，添加4_(3_氯-5_三氟甲基_4,5_二氫異 口琴唾-5-基）-2-曱基苯胺曱酸第三丁酯〇.5g，並於5〇〇c繼續 授摔90分鐘。反應完結後，將反應混合物注入200ml之 水中’用乙酸乙酯萃取（1〇〇mlx 2)，將有機層用飽和食鹽 水及無水疏酸鎂依次脫水及乾燥後，於減壓下餾去溶劑。 將殘留固體用矽膠管柱層析（其中用乙酸乙酯-己烷（3 : 7) /谷出）精製’得到為白色結晶之目的物〇 4g。 溶點：4 6.0 至 4 8.0。〇 步驟 2_甲基-4-[3-(1，2,4-三唑_1-基）-5-三氟甲基-4,5- 氫異噚唑-5_基]苯胺之製造 在2-甲基-4-[3-(1，2,4-三唑-1_基）_5-三氟甲基-4,5-二 氫/、咢坐5基]笨胺甲酸第三丁酯〇 4㊂中，於冰冷授拌 :，滴入三氟乙酸5ml。於室溫繼續攪拌1〇分鐘後，於減 C下餾去/谷劑，將殘餘物溶於乙醚$ ο—，並用飽和碳酸氫 鈉水办液50ml洗淨。將有機層用無水硫酸鎂脫水後，於 咸[下餾去,合得到為淡黃色油狀物質之粗製目的物 〇.3g。其在未精製下，用於下一反應。 步驟4 : 3-碘-N2-異丙基 NL[2-甲基-4-[3-(l，2,4-三唑-1- 604 314918 200407073 基）-5-三氟甲基_4,5 胺之製造 氫異噚唑-5-基]苯基]鄰笨
在HN-異丙基_胺酸〇而之甲笨 中，於室溫下授拌，滴入三氣心液 擰胜m八於％ 听υ·35§。於同溫度下 二。二/於減•下顧去溶劑’將殘餘物溶於四氫咲 喃陶中，添加2_甲基佩2,〜“基)_5二：甲夫 基^4,5-二氫異Df^5-基]苯m並於室溫繼續攪拌18 小…應元結後，於減壓下餾去溶劑，將殘留之固體用 矽膠管柱層析（其中用乙酸乙醋_ 口拉用 到為白色結晶之目的物。.4g。 （ 6)洛出)精製’得 熔點：131.0 至 133.0t： 8-2l (d, J=7.8Hz, lH)t 7*2'7-5 (¾ 3H), 5.83 (d, (d· J=17.8Hz, 1H), 2.38 iHNMR (CDCI3, Me4Si，300MHz) 5 8.80 (s，1H)，8 44 (bs 1H) 8.08 (s, 1H), 7.98 (d, J=6.8Hz, 1H), 7.82 (d. J=6.8Hz/lH) J=8.0Hz，1H)，4·29 (d，J=17,8Hz，1H)，4.卜4.3 (m，1H)，4.00 (s，3H)，1.16 (d，J=6.6Hz, 6H)· 合成例1 2 N〗-[4-[3-(4-氯笨基）_5-環丙基_4,5_二氫異噚唑_5_基卜2_甲 基苯基]-3_碘-N2_異丙基鄰苯二酸二醯胺（本發明化合物2 013) ° 步驟1 : 4-環丙羰基-2-曱基笨胺曱酸第三丁黯之製造 在氮氣環境下之4 -埃-2-甲基苯胺甲酸第三丁 , $ 6g 之第三丁基曱基醚48ml溶液中，於-3〇。〇攪拌下，滴入正 丁基鐘（1.6M) 15.1m卜並於滴入終了後升溫至ye，然後再 攪拌1 0分鐘。繼而，將該反應混合物冷卻至_ 7 8，添力 環丙烷羧酸曱酯2.7g，於同溫度攪拌4小時，繼而於〇 314918 605 200407073 繼續攪拌2小時。反應完結後，在反應混合物中加入飽和 氯化錢水溶液100m卜用乙醚萃取〇〇〇mlx 2广將有機層用 飽和食鹽水及無水硫酸鎂依次脫水及乾燥後，於減壓下餾 去溶劑。將殘留固體用矽膠管柱層析（其中用乙酸乙酯-己 為白色結晶之目的物〇 _ 9 3 g。 W, J=8.7Hz, 1H), 7.89 (dd, J=8.7, 2.1Hz, 1H), 2.6-2.7 (m, 1H), 2.30 (s, 3H), 1.54 (s, 9H), 烷（1 : 5)溶出）精製，得到 H NMR (CDC13, Me^Si, 300ΜΗζ) ό 8. 10 7-82 (d, l.5Hz, 1H), 6.50 (s, 1H), 1·15-1.25 (in 2H), 〇. 9-1.05 (m，2H). 2 4(1 %丙基乙烯基）_2_甲基苯胺甲酸第三丁酯之製 造 在鼠氣環境下之二&amp; l 一本基曱基鳞溴化物3 .〇g之四氫呋 喃2 5 m 1懸浮液中，於冰；人 不~攪拌下，滴入正丁基鋰（L6M)5.1 m 1，並於同溫度下擔牲 見+ 50刀鐘。繼而，將該反應混合物 於冰冷攪拌及氮氣環境下，、京λ Λ ^工 兄卜滴入4-¾丙羰基-2-甲基苯胺甲 酸第三丁酯〇.93g之四养吐+。， 虱夫喃8ml溶液中，滴入終了後， 於室溫繼續攪拌5小時。后霜〜从# 反應元結後，在反應混合物中加 入100ml水，用乙醚萃取 碰， 取（100mlx 2)，將有機層用飽和食 1水及然水硫酸鎮依次脫水 &amp;及乾秌後，於減壓下德去溶 劑。將殘留固體用矽膠管 ^ &amp;柱層析（其中用乙酸乙酯-己烷 (1 : 10)溶出）精製，得 出賺_3, 300_ 07 白色—之目的物O.W。 7.37 (d，H. 8Hz，1H)，6.26 (s，1Η) ·8·】ΗΖ，1H)，7.42 (dd，风 1，1·8Ηζ，1H), (in, 1Η), 1.53 (s, 9Η), 〇 75-η ^ ^ ^ 4*(S，1Η)* 2· 26 ^ 3Η)- 1· 5δ- U 0.85 (πι，2Η)，0.5-0.6 (πι 9Η) 步驟3 : 4-[3-(心氣ι其、c 4本基環丙基-4 — 2-帀其梦…田缺- ，J 一虱兴％唑-5-基]- 2甲基本胺甲酸弟三丁酯之製造 在4-氯苯基醛肟〇 8 — g之1—-一甲氧乙烷25ml溶液 314938 606 200407073 中，添加N-氯琥珀醯亞胺〇.68g，並於70°C攪拌1小時。 將反應混合物冰冷後，添加4 - (1 -環丙基乙稀基）-2 -曱基笨 胺曱酸第二丁 0 · 5 5 g及破酸氫卸3 · 6 g，然後於室溫再繼 續攪拌6小時。反應完結後，於減壓下餾去溶劑，在殘留 物中添加乙30ml及水30ml ’分取乙_層，將水層用乙 謎30 ml萃取，然後將有機層合併，用飽和食鹽水及無水 硫酸鎭依次脫水、乾燥及於減壓下餾去溶劑。將殘留固體 用矽膠管柱層析（其中用乙酸乙酯-己烷（1:1〇)溶出）精製， 付到為白色結晶之目的物0.6 g。 1H)，7· 58 (dt，1=9.0，2.1Hz, 2H) 26 (S，軋 1·52 (s, 9H), i.h’5 1HNMR (CDC1S，Me4Si，300MHz) δ7·81 (d，J=9.3Hz, 7.25-7.4 (m, 4H), 6.25 (bs, 1H), 3.49 (s, 2H), 2. (m’ 1H)，M5-0.6 (m, 4H). 氫異嗜唑-5 -基]_ 步驟4 : 4-[3-(4-氯苯基）-5-環丙基-4,5·二 2-甲基笨胺之製造 在4 — [3-(4-氯苯基&gt;5-環丙基-4,5-二^[1『^&lt;甘 甲其# 氧異％唑-5-基]_2_ 土本胺甲酸第三丁酯〇.59g中，於冰 氟乙酸+ m 7攪拌下，滴入三 。在同溫度下繼續攪拌5分 去溶劑，π , 趄後，於減壓下餾 传到為褐色油狀物質之粗製目的仏 ^ 製下用；c , 的物。其可在未精 々、下一反應。 步驟5 · χτ1 N 4443-(4-氯苯基）-5-環丙基、4 s 产田口口 基]、2·甲|〜 4,5-二氫異噚唑-5- 暴本基]-3_碘-N2-異丙基鄰苯二酸_ 在 ^ 一醯胺之製造 、峨異丙基酞醯胺酸〇·53 中，於室ms〈甲本l〇ml溶液 攪拌3〇八# y 0.37ml。於同溫度 刀、.里後’於減壓下儲去溶劑’將薅c 廿 貝溶於 ^ ^邊之頁色油狀物 風呋喃1 7 m 1中，加入在步驟4 ¥ 4中得到之粗製‘ 314918 607 200407073
[3-(4-氣苯基）-5-環丙基-4,5-二氫異曙唑_5-基]_2_甲基苯 胺，並於室溫繼續攪拌17小時。反應完結後，於減壓下餾 去溶劑，將殘留之固體用矽膠管柱層析（其中用乙酸乙酯_ 己烷（1 ·· 2)溶出）精製，得到為白色結晶之目的物〇.21g。 熔點：178.0 至 180.0°C Ή 醒（CDC13, Me4Si，300_ 5 8.32 (bs，1Η), 7·96 (t，㈣他 2H) ? ?? (d M.2HZ, 1H), 7.58 (dt, J=8.4, 1.8Hz, 2H), 7.3-7.4 k 4H), 7.18 (t, J=7.5Hz, IH)' 5.91 (d，J=8.1Hz，1H)，4 15-4.3 (m，1H)，3.5! (s, 2H)，2.32 (s, 3H), 1 4-1 5 (m ih) 1. 18 (d，J=6.6Hz，6H)，0.45-0.65 (m，4H). ’ · · ’ ’ 合成例13 ：^1-[4-[3-(4-氯苯基）-5-七氟丙基_4,5-二氫異嗜唑_5_基]_2_ 曱基苯基]-3-碘-N2-異丙基鄰苯二酸二醯胺（本發明化合物 2,059 號） 步驟1:4-(2,2,3,3,4,4,4-七氟-1_羥基-1-甲基丁基）_2-甲基 苯胺甲酸第三丁酯之製造 在氮氣環境下之4-碘-2-曱基苯胺甲酸第三丁酯4.2g 之乙&amp;$ 100ml溶液中，於_2(rc及攪拌下，滴入正丁基鋰 (1 ·57Μ己烷溶液）i7ml，並於滴入終了後升溫至〇〇c，然 後再攪拌1 5分鐘。繼而，將該反應混合物冷卻至_78〇c， 添加七氟丙基曱基酮2.0g，慢慢升溫至室溫，於室溫再繼 續攪拌2小時。反應完結後，在反應混合物中加入飽和氯 化錢水溶液1 0〇m卜分取有機層，用飽和食鹽水及無水硫 酸錢依次脫水、乾燥及於減壓下餾去溶劑。將殘留固體用 矽膠官柱層析（其中用乙酸乙酯-己烷（丨：9)溶出）精製，得 到為淡黃色油狀物質之目的物1.3 g。 608 3149J8 200407073 n〇2a3t: 1.4557 1H), !H NMR (CDC13, Me4Si, 300MHz) (5 7.88 (d, J=9.3Hzt 1H), 7.34 (¾ 2H), 631 2.59 (bs，IH)，2.27 (s，3H)，1.78 (s, 3H)，1.53 (s，9H). · S’ 步驟2: 4-(丨_七氟丙基乙烯基甲基苯胺甲酸第三丁酯之 製造 θ 在；（2,2,3,3,4,4,4-七氟-卜羥基-1-甲基丁基）_2-甲基 苯胺甲酸第三丁酯LOg之四氫呋喃5ml溶液中，於冰冷授 拌下，添加第三丁氧化鉀〇.56g及三氟乙酸酐llg，並於 同溫度攪拌丨5分鐘。然後在該反應混合物中，追加第三丁 氧化鉀1.7g及三氟乙酸酐i.lg，然後升溫至室溫，並於室 溫再繼續攪拌3小時。反應完結後，將反應混合物注入冰 水5〇ml中，用乙酸乙酯萃取（3〇mlx 3)，將有機層用飽和 食鹽水及無水硫酸鎂依次脫水、乾燥及於減壓下餾去溶 劑。將殘留固體用矽膠管柱層析（其中用乙酸乙酯_己烷 (3 · 17)溶出）精製，得到為白色結晶之目的物〇.8g。 熔點：50.0 至 53.5°C ⑴麵（CDCI3，Meji，300MHz) ό7·88 (d，J=8.7Hz，1H), 7.20 (d, J=8.7Hz 1H) 7 15 (ς 1H), 6.31 (bs, 1H), 5.92 (s, 1H), 5.75 (s, 1H), 2.26 (s. 3H), 1.53 (s/9H)/ * ， 步驟3 : 4-[3-(4-氯苯基）-5_七氟丙基-4,5_二氫異噚唑_5_基] -2-甲基苯胺甲酸第三丁酯之製造 在4-(1-七氟丙基乙烯基）_2_曱基笨胺甲酸第三丁酯 〇.4g及在合成例5之步驟}中合成之肛氯苯基異羥肟酸氯 化物〇.29g之N，N-二甲基甲醯胺2〇ml溶液中，添加三乙 胺〇· 1 6g，並於至溫攪拌2小時。繼而，追加4-氯苯基異 羥柄酸氯化物〇;9§及二乙胺〇· I 6g，然後於室溫再繼續授 314918 609 200407073 拌3 ·5小時。反應完結後，將反應混合物用乙酸乙酯80ml 稀釋，用水50ml洗淨後，用飽和食鹽水及無水硫酸鎭依 次脫水，乾燥及於減壓下餾去溶劑。將殘留物用矽膠管柱 層析（其中用乙酸乙酯-己烷（1 : 4)溶出）精製，得到為黃色 油狀物質之目的物0.5 g。 !H NMR (CDC13i Me4Si, 300ΜΗζ) δ 7.97 (d, 1=8.8Hz, 1H), 7.59 (d, J=8.8Hz, 2H), 7,35-7.45 (m, 4H), 6.33 (bs, 1H), 4.20 (d, J=17.0Hz, 1H), 3.68 (d, J=17.0Hz, 1H), 2.28 (s 3H), 1.52 (s, 9H). ’ · ’ 步驟4:4-[3-(4 -氯苯基）-5 -七氟丙基-4,5-二氫異噚唾_5_基] -2-甲基苯胺之製造 在4-[3-(4 -氣苯基）-5-七氟丙基_4,5-二氫異卩萼。坐-5-基] -2-甲基苯胺甲酸第三丁酯〇.45g中，於攪拌及室溫下滴入 三氟乙酸3ml。於同溫度繼續攪拌30分鐘後，於減壓下館 去溶劑，將殘留物溶於乙酸乙酯50m卜用飽和碳酸氫鈉水 溶液50ml及水50ml依次洗淨，用飽和食鹽水及無水硫酸 鎂依次脫水，乾燥及於減壓下餾去溶劑。將殘留物用矽膠 管柱層析（其中用乙酸乙酯-己烷（1 : 4)溶出）精製，得到為 黃色油狀物質之目的物〇. 3 4 g。 ⑴麵（·3, ^Si, 300_ δ7,59 (d，J=6 9Hz，2H), 7 38 (d j=6 9Hz 2H) ta 2H), 6.68 (d. J=8.1Hz. 1H), 4.16 (d, J=17. 1Hz, 1H), 3.65-3.75 (ni 3H)/2.19 (s 步驟5 · N -[4-[3-(4-氯苯基）-5-七氟丙基-4,5_二氫異卩等唑_ 5-基]-2-曱基苯基;碘屮ι異丙基鄰苯二酸二醯胺之製造 在3-碘異丙基酞醯胺酸〇22g之曱笨^丨溶液中， 方' 冰冷攪拌下滴入二氟乙酸酐〇 2丨g。於同溫度攪拌3 〇分 鐘後’於減壓下餾去溶劑，將殘留之黃色油狀物質溶於乙 314918 610 200407073 腈5 m卜然後於室溫滴步 ,, 步驟4付到之4-[3-(4-氯苯基）_5_ 七氟丙基-4,5_二氫異噚唑_5_ 土]_2·甲基本胺〇.3g之乙腈 5ml溶液，並於同溫度 、占h 、 丹、k，攪拌5小時。反應完結後， /慮出不浴物，並於減壓下_ j 谷劑。殘留物藉由從乙腈5nU 曰曰析而精‘ ’得到為白色結晶之目的物〇.22g。
熔點：155.5 至 158.5°C WNMR (CDC13，Me4Si，300MHz) (5 8·42 (bs 1H&gt; M &quot; 风 8Hz, 1H)，7.74 (d，J=7.8Hz 1H) 7βΛ ， 16 (d，J=8,他，I»，7.95 (d， J=7.8Hz. 1H), 6.05 (d J=8 iHz iH) 4 κ 5 ^ 4HK ?* 17 2·35 3H)&gt; 1-13 (d, M8HZ (, 2H), ,7, (d, MUHz, ,H), 合成例1 4 1^[4-[5-(4-*1苯基）-3-甲基-4,5-二氫異,嗤-5_基]-2_甲基 苯基]3碘N -異丙基鄰苯二酸二醯胺（本發明化合物〕_ 006 號） v驟1 4 [1-(4-氯笨基卜^羥乙基]甲基苯胺甲酸第三丁 酯之製造 一 斤在氮氣環境下之仁碘-2_曱基苯胺曱酸第三丁酯3〇g 之第三丁基甲基醚4〇ml溶液中，於_5〇艽及攪拌下，滴入 正丁基鋰（1.5 7M己烷溶液），並於滴入終了後升溫至〇 C :、、丨後再攪拌3 0分鐘。繼而，將該反應混合物冷卻至- 78 C添加仁氯乙醯苯1.39g，慢慢升溫至〇°c，並於同溫 度再、廬續攪拌1小時。反應完結後，在反應混合物中加入 飽和氯化銨水溶液i 〇〇ml，分取有機層，將水層用乙酸乙 鲇1 〇〇ml卒取。將有機層合併，用無水硫酸鎂乾燥及於減 壓下館去溶劑。將殘留物用矽膠管柱層析（其中用乙酸乙酯 314918 611 200407073 得到為黃色油狀物質之目 -己烧（1 · 9至2: 3)溶出）精製 的物1.7 g。
&gt;HNMR (CDCl, Me4Si, 300MHz) 5 7.75 (d J-8 3H 2.21 (s，3H)，2·16 (bs，IH)，1 89 ’ 7·卜7.4 (m，⑽，6.25 (bs，1H)， 0”s，敬 1.51 (s，9H)· 步驟2 : 之製造 4-[1-(4-氯笨基）乙烯基]_2 -甲基苯胺甲酸第三丁酯 在 4-[1-(4 -氯苯基f 其~! ；?工乙基]_2_甲基苯胺甲酸第三丁 醋3.1g之1,2-二氯乙燒2〇ml溶液中，添加對甲苯磺酸一 水合物G.33g，並於室溫㈣3()分鐘。反應完結後，將反 應混合物注入50ml水中，用衰枚贫 τ 用虱仿50ml卒取，將有機層用 飽和碳酸氫鈉水溶液50ml洗淨後，用飽和食鹽水及無水 硫酸鈉依次脫水，乾燥及於減壓下餾去溶劑。將殘留物用 石夕膠管柱層析（其中用乙酸乙酯-己烷（1 : 4)溶出）精製，得 到為黃色結晶之目的物2.6g。
熔點：101.5 至 104.0°C W NMR (CDC13, Me4Si，300MHz) 5 7.80 (d, J=8.4Hz, 1H), 7.2-7.35 k 4H), 7. M (d J-8.4Hz, ]H)f 7.08 (s, 1H), 6.29 (bs, 1H), 5.40 (d, J=l. 0Hz, 1H), 5.36 (d J=] 〇u 1H), 2.23 (s，3H)，1.52 (s，9H). ’ · Z， 步驟3 : 4-[5-(4 -氯苯基）-3 -曱基- 4,5 -二氫異曙。坐基卜2· 曱基苯胺曱酸第三丁酯之製造 在乙醛后〇.41g之N，N-二甲基曱醯胺5ml溶液中，添 加N-氯琥珀醯亞胺0.93g，並於50°C攪拌1小時。繼而， 在反應混合物中添加4-[ 1-(4-氯苯基）乙烯基]-2-甲基笨月安 曱酸第三丁酯〇.8g及三乙胺0.71g，並於室溫再繼續搜掉 1 3小時。反應完結後，將反應混合物注入30ml水中，用 314918 612 乙酉曼乙5旨5 0 m 1 14* τχ· 〜 个取，用無水硫酸鎂乾燥後，並於減壓下 —d將殘留物用矽膠管柱層析（其中用乙酸乙酯-己 ί (二:n)r溶出)精製，得到為黃色油狀物質之目的物〇.46g。 -&quot;Π； ,,,35 , 6H, ,26 1.51 (s, 9H). 6·7ΗΖ' 1HK 3·42 J=16.7Hz, 1H), 2.21 (s, 3H), 1.99 (s, 3H), 步驟4 : 4-[5-(4-氯苯基广3_甲基_4,5_二氫異噚唑_5_基]_2_ 曱基苯胺之製造 在4 [5 (4·氯苯基）-3_曱基_4,5_二氫異噚唑基]_2_曱 基苯胺甲酉义第二丁 s旨Q46g巾，於冰冷授拌下，滴入三氣 -夂5ml於至/最繼續攪拌2〇分鐘後，於減壓下餾去溶劑， 將殘留物溶於乙酸乙3Gml中’用飽和碳酸氫鈉水溶液 2〇ml洗淨。將有機層用無水硫酸鈉乾燥後，於減壓下餾去 /合劑，付到為褐色油狀物質之粗製目的物〇 。將其在 未精製下，用於下一反應。 7.04 (s, 1H), 6.97 (d, J=8. 1Hz, 16.8Hz, 1H), 2.13 (s, 3H), 1H)， 1. 99 Η 醜（CDCI3，Me4Si，300MHz) ό7·25-7·4 (m，4H)， 6.61 (d, J=8. 1Hz, 1H), 3.5-3.7 (m, 3H), 3.35 (d (s，3H)· s 步驟5 : 氯苯基）-3-甲基-4,5-二氫異曙唑j基] -2 -甲基苯基]-3-埃-N2-異丙基鄰苯二酸二酸胺 在3-碘異丙基酞醯胺酸〇46§之甲苯Μ〗溶液中， 於室溫及攪拌下，滴入三氟乙酸酐〇 37ml。於同溫度攪拌 2小時後，於減壓下餾去溶劑，將殘留物溶於乙腈2 5mi， 添加在步驟4中得到之粗製4-[5-(4-氯苯基）-3 -甲基-4 5· 一氫異卩萼唑-5-基]-2 -甲基苯胺〇.34g，並於室溫繼續攪拌 2 · 5小時。反應完結後，濾出析出之結晶，用少量乙腈、先 314918 613 200407073 淨，得到為白色結晶之目的物〇 36g。 炼點：145·5 至 148.5t： Ή 腿（CDC13, _，3_ζ) ό8 31 如，鼠 7 j 沾㈣版 J 8. 1Hz, 1H), 7.77 (d, J=7.5Hz, 1H), 7.1-7.4 (m, 7H), 5.85 (d, J=8. 1Hz, 1H), 4.15- • (m’ 1H)，3.56 (d，J=16.5Hz，1H)，3.43 (d，&gt;161，1H)，2.28 (s, 3H&gt;, 2.00 (s， 3H), 1.17 (d, J=6.6Hz, 6H). 合成例1 5 &gt;^-[4-[2-(4-氯苯基）-5-三氟甲基-4,5_二氫異噚唑_5-基] 甲基苯基]-3-蛾_N2-異丙基鄰笨二酸二醯胺（本發明化合物 4-02 號） 步驟1 · 2-甲基-4-(1-三氟曱基環氧乙烷-；1-基）苯胺曱酸第 三丁酯之製造 在合成例1之步驟1至步驟2中合成之2-甲基-4-(卜 三氟曱基乙烯基）苯胺甲酸第三丁酯3 〇g之氯仿5〇ml溶液 中，添加3 -氯過苯甲酸3 · 5 g，並於室溫攪拌3日。反應完 結後，將反應混合物用10%亞硫酸氫鈉水溶液5〇ml、飽和 碳酸氫鈉水溶液50ml及水50ml依次洗淨。將有機層用無 水硫酸鎮乾燥後’於減壓下餾去溶劑，得到為淡黃色結晶 之目的物2.9g。
熔點：88.0 至 90.0°C 旧酿 _3, Me况 300MHz) &lt;5 7.93 'υ._，氣,八4 他 3.38 (d, J=5.2Hz, 1H), 2.89 (d, J=5.2Hz, 1H), 2.27 (s, 3H), 1. 53 (s, 9H)* ’ 步驟2 : 4-(2-胺基-1-羥基-l-三氟甲基乙基曱基苯胺甲 酸第三丁酯之製造 酸第 在2-曱基-4-(1-三氟曱基環氧.乙烷基）笨胺甲 314918 614 200407073 三….9g之四氫吹喃30ml溶液中，添加ι〇%氨 液则’並於室溫攪拌3曰。反應完結後，於減壓下餚去 溶劑，得到為淡黃色油之目的物 於下一反應。 &amp;將其在未精製下用 步驟3 · 4 - [ 2 - ( 4，氣节西夜日念其\ 一甘 妝基)-1，基三氟甲基乙基]-2- 曱基本胺曱酸第三丁酯之製造 广♦胺基小經基三氟甲基乙基)士甲基苯胺甲 鲅弟二丁 I旨2.0g之乙醚3〇ml溶液中，添加水偏，碳酸
納^叫及心氯节醯基氣化物丄·、，並於室溫授拌3小 時。反應完結後，分取有機層，用水5〇如洗淨後，用益 水硫酸鎂乾燥，並於減壓下餾去溶劑。將殘留之固體從二 異丙醚中再結晶，得到為無色結晶之目的物 熔點：160.0 至 162.0°C 7.36(, ^3.0. ,6Hz, 1H), ,87 (d, J=1, 〇, , 6Hz. m)，V&quot;： 3Η)^Τ2 (Γ 9H) ^ 步驟4:4-[2-(4-氯苯基）-.5-三氟甲基Μ-二氫異.坐_5_基] -2 -曱基苯胺甲酸第三丁 g旨之製造 在4-[2-(4-氣卞酿胺基）-1_經基小三氟甲基乙基]J曱 基苯胺甲酸第三丁醋〇.5川比。定1〇ml溶液中添加氧氣化 碟〇.32g，並於6〇。〇授拌2小時。反應完結後，於減壓下 餾去溶劑，將殘留物投入50ml之水中，用乙醚萃取（5〇mi X 2) ’將有機層用水洗後’ 無水硫酸鎂乾燥，並於減壓 下餾去溶劑。將殘留物用矽膠管柱層析（其中用乙酸乙醋_ 己烷U : 4)溶出）精製，得到為無色樹脂狀物質之目的物曰 314918 615 200407073 0.35g ° 丨HNMR _3,㈣丨，300刪 β7·98 (d，风 8Hz，2H) , 7 96 (d J=8.8Hz, 2H), 7.2-7.4 (m, 2H), 6.33 (bs 1H) 4 71 M τ' · ，1H)，7.44 (d, 他，1H&gt;，UHs,鼠 L53 (s. 9H) ’ 471 (d，J=15屬，亂 4·33 (d. 步驟5: 4-[2-(4-氯苯基）-5-三氟甲基^-二氫異噚唑_5_基] -2-甲基苯胺之製造 在4-[2-(4-氣苯基）-5_三氟甲基-4,5_二氣異嗜嗤_5_基] -2-曱基苯胺甲酸第三丁 s| G.35g中’於冰冷檀拌下，滴入 三氟乙酸5ml。於室溫繼續授拌1〇分鐘後，於減壓下館去 溶劑’在殘留之油狀物質中加入乙鱗5〇ml中’用餘和碳 酸氫m容液5〇ml及水5—依次洗淨。將有機層用益水 硫酸鎖乾燥後，於減屋下館去溶劑，得到為淡黃色樹脂狀 物質之目的物〇.33g。 WNMR (CDC13, Me4Si，300MHz) (5 7.99 (d, J=8.8Hz to, 2H), 6.69 (d, J=9. 1Hz, 1H), 4.68 (d, J=15 4HZ 1H) 4 〇/ J~8* 8Ηζ· 2H), 7.1-7.3 (bs，2H)，2·19 (s, 3H). · ，H，4.34 (d，J=】5.他，1H), 3.00 步驟 6 : &quot;_[4-[2-(4-氯苯基g 《甘] J 一鼠甲基_4,5-二氫異噚唑- -土 -2-甲基$基]_3·蛾-n2_異丙基鄰苯二酸二酿胺之事迕 :3-碘異丙基酞醒胺酸〇 4g之甲苯胸溶液；， ;冰~攪拌下，滴入三氟乙酸 分鐘。於诖两 时〇·4§ ’並於室溫攪拌30 中 Μ下館去溶劑後，將殘留物溶於四氫咲喃1〇丨 中’添加4-[2_(4_氯苯基 二夫南㈣ 美1 9田甘# —亂甲基_4,5-二氫異噚唑 基]1甲基苯胺G.33g，並於室 ^ 後，於、成颅τ〜償许1 2小k。反應完社 二：:昼下餘去溶劑，將殘留之固體 ：(： 中用乙酸乙酿-氯仿（1 : 9)溶出Η生制 狂屬析（其 目的物0.3g。 以衣，得到為無色結晶之 3J4918 616 200407073
熔點：138·〇 至 140.0°C 腿（CDC13，Me4Si，30(]_ ό 8.41 (bs，1H)，8· 18 (d, J:8· 5Hz，1H)，7.98 (d J-8. 8Hz，2H)，7· 9-8· 0 (m，1H), 7.46 (dt 1=8.8Hz, 2H), 7.1-7.4 (m, 4H), 5.79 (d J=8.0Hz, 1H), 4.73 (d, J=15.7Hz, 1H), 4.34 (d, J=15.7Hz, 1H), 4.1-4.3 (m,' 1H), 2 37 (s, 3H), 1.13 (dt 1=6. 1Hz, 6H). ，. 合成例1 6 N -[4-[2-(4 -氣苯基）-5-三氟甲基-4,5_二氫嚷唾_5_基]甲 基苯基]-3-碘-N2-異丙基鄰苯二酸二醯胺（本發明化合物4_ 04號） 步驟1 : 4-[2-(4-氯苯基）-5-三氟甲基-4,5-二氫噻唑-5-基] 2-甲基苯胺之製造 在合成例15之步驟1至步驟3中合成之4-[2-(4-氣苄 醯胺基）-1·羥基-1-三氟甲基乙基]-2-甲基苯胺甲酸第三丁 酯l.Og溶於曱苯2〇ml之溶液中，添加羅松試藥i 〇g，並 於加熱回/^下攪;拌1小時。反應完結後，冷卻至室溫，濾 出不/谷物後’將濾液用水5 〇 m 1洗淨’用無水硫酸鎮乾燥， 並於減壓下餾去溶劑。將殘留物用矽膠管柱層析（其中用乙 酸乙s旨-己烧（1:4)溶出）精製，得到為無色樹脂狀物質之目 NMR (CDC13，Me4Si, 300MHz) 7· 0-7· 2 (e 2H), 6· 6-6. 7 (¾ 3.73 (bs, 2Η)，2·19 (s, 3Η). ^57.76 (d, J^SHz, 2H), 1H), 5.82 (d, J-17. 〇HZt ]H) 7.41 (d, J=8. 5Hz, 2H), 4.71 (d, J=17.0Hz, lH)f 步驟2:NM4-[2-(4-氯苯基）_5-三氟甲基_4,5-二氫噻唾_5_ 基]-2-甲基苯基]_3冬n2_異丙基鄰笨二酸二酿胺 在3-碘·Ν-異丙基酞醯胺酸〇,之甲苯i 〇m]溶液中， 於冰冷攪拌下’滴入三氟乙酸酐〇,，並於室溫攪拌 3]49】8 617 200407073 分鐘。於減壓下餾去溶劑後，將殘留物溶於乙腈胸中， 添加4-[2_(4_氯苯基）_5_三1甲基
基苯胺〇.4g’並於室溫授拌5小時。反應完結後，於減壓 下館去溶劑’冑殘留之固體用石夕踢管柱層析（其中用乙酸乙 醋-己烷（2: 3)溶出）精製，得到為無色結晶之目的物〇.35§。 熔點·· 121.0 至 123.(TC 麵 _3, Me4Si，30_) (5 8.41 (bs，1H), 8·27 (d &gt;6 6HZ 1H) 7 97 (d J=6.6Hz, 1H), 7.78 (d，J=8 5Hz 2H) 7 7 7 o , Z，1HK 7*97 (d 7 1 -7 3 (πι 3H) Υ (瓜，鼠 7.42 (d，J=8.5Hz，2H)， ^•〇H，1H), 4.1-,2(, 1H), ,35 (, 3,, L 15 (d, J=, 〇„〇^ J&quot;' ^ 合成例17 : NM4-[l-(4-氯苯基）_3_甲基_4,5_二氫吡峻巧_ 基]-2-甲基苯基]_3_峨_1^_異丙基鄰苯二酸二醯胺（本發明 化合物6-02號） 步驟1 : 4-(3-酮基小丁稀基）_2_甲基苯胺甲酸第三丁酿之 製造 在心碘-2甲基苯胺曱酸第三丁酯3 〇g及曱基乙烯基 _ 1.26g之N-曱基吡咯烷酮2〇ml溶液中，添加二氯雙（三 苯膦）鈀0.126g及碳酸氫鈉L51g，在熱壓器中於13〇它攪 拌90分鐘。繼而，在該反應混合物中追加曱基乙烯基酮 •26g 一氣雙（二笨膦）纪0.126g及碳酸氫鈉丨54，並於 同溫度再繼續攪拌90分鐘。反應完結後，將反應混合物注 入100ml之水中，用乙醚1〇〇mi萃取，將有機層用無水硫 酸鎂乾燥後，於減壓下餾去溶劑。將殘留物用矽膠管柱層 析（其中用乙酸乙酯-己烷（1 : 9至2: 3)溶出）精製，得到為 褐色固體之目的物2.0g。 314918 618 200407073
熔點：1 1 6.5 至 11 9 · 0 °C 7.44 (d, J-16.5Hz, 1H), 1H)，6.41 (bs，ih), 2.36 職（CDC13，Me4Si，300MHz) δ 7.99 (d, j=8 4Hz m 7.39 (d，J=8.4Hz，1H)，7.34 (s，1H)，6.63 (d,· J=16 服’ (s，3H), 2,27 (s，3H), 1.54 (s, 9H). ’ ·’ 氣笨基)-”基—。—甲 在4-(3-酮基-1-丁烯基）_2_甲基苯胺甲酸第三丁酯 〇.5g溶於4ml曱苯之溶液中，添加4_氯苯基肼鹽酸鹽 及對-甲苯磺酸一水合物〇.3lg，並於加熱回流下攪拌i小 時。反應完結後’放冷至室1，在反應混合物中加入飽和 碳酸氫鈉水溶液50ml，用乙酸乙酯5〇mi萃取，將有機層 用無水硫酸鎂乾燥後，於減壓下餾去溶劑。將殘留之褐色 固體用二異丙醚3ml及乙醚lmi洗淨，得到為褐色固體之 目的物0.43g。
熔點：180.0 至 184.5°C H_ _3, _，300_ δ7.〇6 他㈣鳥，亂仏 J=9.0H, 2H). 6.62 (d. J=8.1Hz, 1H), 4.84 (dd, 1=11.7, 8. 1H, 1H)' 3 66 b 3(s353：d' J=17·7' 1L7HZ' 1H)· ,). η3'Γ3；·22：5' 步驟3 : NM4-[l-(4-氯笨基）_3_甲基-4,5_二氫吡唑基卜 2 -甲基笨基]-3-埃-N2-異丙基鄰苯二酸二酿胺之製造 在3-埃異丙基酞醯胺酸〇27g之甲笨5〇11溶液中， 於室溫及攪拌下，添加三氟乙酸酐〇.2g，並於同溫度攪拌 1小時。於減壓下餾去溶劑後，將殘留物溶於乙腈4ml， 添加4-[l-(4-氯笨基甲基_4,5_二氫吡唑基曱基笨 胺〇.2g，並於室溫攪拌丨7小時。反應完結後，濾出析出 314918 619 200407073 之固體，用少量之乙腈洗淨，得到為白色結晶之目的物 0.3g。 2H)，7. 77 (d，J=7. 8Hz， J=8· 1Hz, 1H)，4·91 (dd, 12.0Hz, 1H), 2.71 (dd, J-6.6, 3.0Hz, 6H). 熔點：222.5 至 224.5°C •H NMR (CDCl；, Me4Si, 300MHz) 5 8.28 (bs, 1H), 7.9-8.0 (m, 1H), 7.0-7.25 (m，5H)，6. 83 (d, J=9.3Hz，2H&gt;，5·85 (d， 1=12.0, 8.1Hz, 1H), 4.15-4.3 (m, 1H), 3.40 (dd, 7&gt; J=17· 7，8.1Hz， 1H), 2.27 (s，3H)，2.06 (s，犯)，1.17 (dd， 合成例1 8 心-[4-[3-(4 -氯苯基）-1-曱基-5-—氟甲基-4,5、二氫|1比哇_5_ 基]-2-甲基苯基]-3&quot;峨-N2-秀丙基鄉本二酸二酿胺（本發明 化合物6-04號） 步驟1 : 4-氯苯甲醯曱基三苯基鱗溴化物之製造 在4-氯苯甲醯甲基溴化物5.〇g之四氫呋喃3〇m溶液 中’添加三苯膦5 · 6 g ’並於5 〇 C檀拌3小時。反應完結後， 濾出固體，用四氫呋喃洗淨’得到為白色結晶之目的物 9.0g。 熔點&gt; 255.0°C (分解） W 職（CDC13, Me4Si’ 300MHz) 5 8.38 (d，J=8· 5Hz，2H)，7· 6〜8· 1 (m，15H) 7 49 (d J=S-5Hz, 2H), 6.39 (d, J=12.4Hz, 2H). ’ ’ · ’ 步驟2: 1-(4-氣苯基）-4-三氟-2-三苯基亞正膦基_i，3_ 丁二 酮之製造 在4-氯苯甲醯甲基三苯基鱗溴化物5.〇g及三乙胺12g 混於氯仿50ml之混合物中，於冰冷攪拌下滴入三氣乙酸 酐2.4g，滴入終了後於室溫授拌24小時。反應完結後， 用水5〇ml洗淨混合物，用無水硫酸鎂乾燥，並於減壓不 314918 620 200407073
餾去溶劑。將殘留物用矽膠管柱層析（其中用乙酸乙酿氯 仿ο :溶出）精製，得到為淡黃色結晶之目的物3 8g。'' 熔點·· 174.0 至 176.CTC 7-4-7.7 (m, )5H), 7.33 (d, NMR (CDC13, Me4Si, 300MHz) 6 7.78 (d, J=8,5Hz 2Hi J=8.5Hz，2H). * ’ 基-1-丙烯基 步驟3 : 4-[3-(4_氣苯基）_3_酮基三說甲 甲基苯胺曱酸第三丁酯之製造 在氮氣環境下之4-碘-2-曱基笨胺曱酸第三丁醋3.〇§ 之乙醚100ml溶液中，於_10。〇及攪拌下，滴入正丁基鋰 (ϋ己烧溶液叩心丨，滴入終了後，在同溫度攪掉^ $鐘。繼而，將該反應混合物冷卻至_78它，添加丨气氣 苯基）-4-三氟-2-三苯基亞正膦基_丨，3_丁二酮46g，經3小 時升溫至（rc，於οχ；滴入胸之2N鹽酸，然後於室溫 繼續激烈攪拌3小時。反應完結後，遽出不溶物，分取濾 液之有機層，用水50ml洗淨後，用無水硫酸鎂乾燥，並〜 於減壓下鶴去溶劑。將殘留物用切管柱層析（其中用乙酸 乙酿-己烷（1 : 4)溶出）精製，得到為淡黃色結晶之目的物 1.3g。
熔點：72.0 至 74.(TC 1H), 7.74 (d, J=8. 5Hz, 2H), 1H), 2.15 (s, 3H), 1.49 (s, HNMR (CDCI3，Meji，300_) &lt;5 7.86 (d，J=8〇Hz 7*35 (d, J=8.5Hz, 2H), 7.0^7.2 (m, 3H), 6.26 (bs； 步驟4 · 4-[3-(4-氯苯基）小甲基巧·三說甲基_4,5_二氫吼哇 -5-基]-2-甲基苯胺甲酸第三丁酯之製造 在4_ί&gt;(4-氯苯基酮基三氟甲基丙烯基]j一 3]49】8 621 200407073 甲基苯胺曱酸第三丁酯0.8g之乙龄c ,R+f 、 g之乙醇50m溶液中，添加曱 基肼l.Og，並於45°c加熱攪拌4小 ^ ^ ^ *、 j、吩。反應完結後，將反 應混合物注入冰水3 〇 〇 πι 1中，用7 ^用乙醚萃取（lOOmlx 3)，將 有機層用飽和食鹽水及無水硫酸 文錢依次脫水，乾燥及於減 壓下错去溶劑。將殘留物用矽膠管杈 / &amp;往層析（其中用乙酸乙酯 -己燒（1 : 9)溶出）精製，得到為無色樹脂狀物質之目的物 0.5g。 ，H NMR (CDCI3, Me4Si, 300MHz) (5 7.88 (d, J=8 2Hz 1H) 7 no 7·33 ^ ^.5Hz, 2H), ,2-,5 (m, 2ffi, ,30'^' ^ 2H)' 3-39 (d. M7.6HZ, 1H). 2.98 (s, 3H), 2.26 (s, 3H)', i. 52 (s m ^ 1H)' 步驟5: 4-[3-(4-氯苯基）]_曱基_5_三氣甲基_4.,5_二氯卩比啥 一 5-基]-2-甲基苯胺之製造 在4-[3-(4-氣苯基）小甲基-5_三氟甲基_4,5_二氯吼嗤- 5-基甲基苯胺甲酸第三丁醋G4g中，於冰冷檀掉下， 滴入三氟乙酸5以。於室溫繼續攪拌1〇分鐘後，於減界下 溶劑，在殘留之油狀物質中加入乙喊—，用飽：碳 =虱鈉水溶液5〇ml及水⑽…接續洗淨。將有機層用血水 =酸鎮乾燥，於減壓下潑去溶劑，得到為無色樹脂狀物質 之目的物0.3 5 g。 ^ N.MR (CDC]3, Me4Si, 300MHz) (5 8.45 (bs, 2H), 7.49 (d j.〇 ςπ om ^.35 (d, J=,5H, 2H), ,89 (d, J=,7.6Hz, 1H), 3 3 (d &quot; , ^ ^5 ^ (s，3H)，2·42 (s, 3H). ·37 (d，J=17.6Hz，1H), 3·03 步驟6 : N】-[4-[3-(4-氯苯基）-1-甲基三氟 卜 氣甲基_4,5-二氫 比。坐-5-基]_2•甲基苯基]_3，_ν2_異丙基鄰苯二酸 之製造 Μ 在3-蜗-N-異丙基献酿胺酸〇.4g之甲苯i〇m丨溶液中， 3J4918 622
/V /J 於冰冷攪拌下，添加三 分鐘。於鳴μ冬 -夂酐〇.4g，並於室溫攪拌30 刀里於减逐下餾去溶劑 加氯苯基）小甲基:夺/以物溶於乙腈胸，添 -2- Ψ A ^ ^ 土 一氟甲基-4,5-二氫吡唑-5-基] f 土本胺〇.3g，並於室溫攪 減壓下抑本w w 小蚪。反應完結後，於 成&amp;下餾去洛劑，將殘留物 醋-氯仿π mm”，/e柱層析（其中用乙酸乙 熔點：90·0至92.。。。、 為無色結晶之目的物。4。 屮醜（CDC13，Me4Si, 300MHZ) ό 8 38 J=8-〇Hz, 1H), 7.80 (d, J=8 4Hz m / H ’ 8·09 (d，J=8·4Hz，氣 7· 96 (d， 2f〇^ U-7.4 (m, 3H), 5.85 (d, J,8 〇, ^ (d，；=8*5HZi 2HK 7*34 (d· 5Hz, 】H)，3.42 (d，J=17.6Hz，1H) 2 9Q / ^*^*&quot;4.3 (m, 1H), 3.85 (d, J=1T. 6Hz, ’ · ，3H)，2.33 (s，，1.17 (d，J:6.6Hz，6H)· 合成例1 9 •3-碘-N2-異丙基-ΝιΓ2_ψ 尸πΒσ 甲基笨基-2-三氟甲基-2,5-二 虱1%唾_2_基）苯基1鄰絮_ —酉文一酿胺（本發明化合物5 - Ο 1號） 步驟1 : 2·甲基-4-三龜7妒甘# 一既乙基本胺甲酸第三丁酯之製造 在氮氣環境下之4-斑。m # μ ^、-2·甲基本胺甲酸第三丁酷i〇.〇g 之乙醚300ml溶液中，认，am 於1〇C及攪拌下，滴入正丁基鋰 (1.5M)45.0ml，滴入终 了你,^ 、、了後，在同溫度攪拌1 5分鐘。繼而， 將該反應混合物冷卻至，t，滴入三氟乙酸乙醋9、，滴 入終了後’於同溫度再繼續擾拌i小時。繼*升溫至_丄〇 °C ’加入2N鹽酸100ml並激烈搜掉後，分取有機層，用 飽和食鹽水及無水硫酸鎮依次脫水、乾燥，並於減壓下餾 去溶劑。將殘留物用石夕膠管柱層析（其中用乙__己烧（ι:4) 溶出）精製’得到為白色結晶之目的物3.2g。
熔點：85.0 至 87.0°C 623 314918 200407073 6-62 (bs, 1H), 旧趣（CDC13· Me4Si，300MHz) (5 8.25 (d J=8.8Hz，1H)，7.8一8 〇 (m&gt; 2H) 2-32 (s, 3H), 1.55 (s, 9H). 步驟2: 2-甲基-4-(4-苯基三氟甲基_2,3,4,5-四氫噚唑_2 基）笨胺甲酸第三丁酯之製造 在2-甲基-4-三氟乙醯基笨胺甲酸第三丁酯2 〇g及2_ 胺基-2-苯基乙醇〇.92g之二甲笨2〇m丨溶液中，添加吡啶 鐵-對-甲苯磺酸鹽〇.16g，然後—面用丁史塔可管除去生成 之水，一面於加熱回流下攪拌8小時。反應完結後，將反 應混合物注入水1 00m中，並用乙酸乙酯萃取（丨〇〇mix 2)， 將有機層水洗後，用無水硫酸鎂乾燥，並於減壓下餾去溶 劑。將殘留物用矽膠管柱層析（其中用乙酸乙酯_己烷（丨：5) 〉谷出）精製’得到為紅色油狀物質之目的物〇 · 3 g。 ]HNMR (CDC13，Me4Si. 300MHz) (5 7.92 (d，J=8.4Hz, 1H)，7.25-7 55 1H)’ 4. 6-4. 75 (m，1H)，4.53 (t，J=7.2Hz, 1H)，4.35-4. 45 (m, 1H) 1H), 2.28 (s, 3H), 1.53 (s, 9H). ’ (瓜 7H)，6.32 (bs， 3- 75 (t, J=8. 4Hzf 步驟3 : 2-曱基-4-(4-苯基-2_三氟曱基_2,5_二氫噚唑_2_基） 苯胺曱酸第三丁酯之製造 在2-甲基-4-(4-苯基-2-三氟曱基_2,3,4,5-四氫噚唑 基）笨胺甲酸第三丁酯0_2g之乙M 10ml溶液中，於冰冷授 拌下，添加碳酸氫鉀0.08g及次亞氯酸第三丁酯〇 lg將反 應混合物升溫至室溫，並於同溫度再繼續攪拌2小時後， 用石夕/喿土過渡並除去不 &gt;谷物’繼而於減壓下德去溶劑。將 殘留物溶於乙醚5ml後，添加鉀二氧化物〇 〇7g及18_冠基 0.0]g並於室溫攪拌2小時，反應完結後，用矽藻土 4除不溶物’並於減壓下餾去溶劑。將殘留物用矽膠管枝 314918 624 200407073 得到為紅色 層析（其中用乙酸乙醋-己烷（1 : 5)溶出）精穿】 油狀物質之目的物0 · 1 5 g。 】HNMR (CDC13, Me4Si, 300MHz) 5 7.91 (d，j=8.他，1H) 5H)，6.32 0)S，1H)，5.30 (d，J=13.7Hz，1H)，5.’14 w，8'7.85 (瓜 2H)，7.‘7·65 (m， 1·52 (s，9H). ' J&quot;13.6Hz, 1H), 2.28 (s, 3H), 氫曙哇-2 -基） 步驟4: 2 -甲基- 4- (4 -苯基-2-三氟甲爲2 $ 苯胺之製造 ’ 在2-甲基-4-(4-苯基-2-三氟甲基 ^ 虱％唑-2-基） 本胺甲酸第三丁醋（M2g中，於冰冷 7欖拌下，滴入三氟乙 酸3ml。於室溫繼續攪拌3〇分 至復於減壓下餾去溶劑， 在殘留之油狀物質中加入乙酸r G黾乙自曰50m卜用飽和碳酸氫鈉 水溶液50ml及水50ml依次洗淨，闲a ^ Τ 用無水硫酸鈉乾燥後， 於減壓下餾去溶劑，得到為褐色 恂巴，由狀物質之目的物0.09g。 !HNMR (CDC13, Me4Si, 300MHz) (5 7.8-7.85 (m, 2H) 74 7 α 1H). 5.28 (d, JM3.6HZ, 1H), 5.,4 (d. J-13： 7Hz； 1H). 3： 7〇 ^ 5H), 6.68 (d, J=8. 1Hz, (bs， 2H), 2.19 (s, 3H). 步驟5· 3-蛾-N2-異丙基-甲美4 n * U T基-心（4-苯基-2-三氟甲基 -2,5-二氫曙唑-2-基）苯基]鄰苯二酸二醯胺之製造 在3-碘-N-異丙基酞醯胺酸〇14g之甲笨丨㈣丨溶液 中，於冰冷攪拌下，添加三氟乙酸野〇13g，並於室溫授 拌j 0刀4里方、減壓下德去溶劑後，將殘留物溶於乙腈 10ml，於室溫攪拌下添加入曱基·4-(4•苯基_2_三氟曱基_ 2,5-一氫1½唑-2-基）苯胺0 09g，並於同溫度繼續攪拌12小 時。反應完結後，濾取析出之固體，用乙腈3—洗淨，得 到為白色^晶之目的物〇 . 〇 6 g。 熔點：222.0 至 223.〇t 314918 625 200407073 Ή NMR (CDC13，Me4Si，300MHz) (5 8.35 (bs，1H), 8.12 (d，J=8.2Hz, m)，7.96 (d J-7.9Hz, 1H), 7.8~7.9 (m, 2H), 7.79 (d, J=7.7Hz, 1H), 7.6-7.7 (m, 2H), 7.45-7 6 (m 3H), 7.20 (t, J=7. 9Hz, 1H), 5.83 (d, J=8. 2Hz, 1H) , 5.32 (d, J=13.7Hz, 1H), 5.17 (d J=13. 6Hz, 1H), 4.15-4.25 (m, 1H), 2.36 (s, 3H), 1.17 (dt J=6.6Hz, 6H). ’ 合成例20 &quot;-[4-[3-(4 -氟苯基）-5-三 l 甲基-1，4,2-二―嗤啉-5_ 基] 曱基苯基]-3-埃-N2-異丙基鄰苯二酸二醯胺（本發明化合物 4-05 號） 步驟1 : 4-[3-(4-氟苯基）-5-三氟甲基-l，4,2-二噚唑啉-5_基] 甲基苯胺甲酸第三丁酯之製造 在合成例19之步驟1合成之2-甲基-4-三氟乙醯基苯 胺曱酸第三丁酯〇.5g及4-氟苯基異羥肟酸氣化物12g(以 與合成例5之步驟1同樣地從ζμ氟苯基醛肟合成）之n，n_ 二曱基甲醯胺30ml溶液中，於室溫攪拌下，滴入〇·7§之 三乙胺，滴入終了後，於同溫度再繼續攪拌2〇小時。反應 完結後，將反應混合物用乙酸乙酯80ml稀釋，水洗（5〇W x 2)後’將有機層用飽和食鹽水及無水硫酸鎂依次脫水、 乾燥及於減壓下餾去溶劑。將殘留物用矽膠管柱層析（其中 用乙酸乙酯-己烷（1 : 3)溶出）精製，得到為淡黃色樹脂狀物 質之目的物1.3 g。 步驟2:4-[3-(4-氟苯基）-5-三氟甲基-1，452-二曙唑啉-5_基] •2-曱基笨胺之製造 土 在4·[3-(4-氟苯基）-5-三氟曱基二噚唑啉巧_基] _2-曱基笨胺曱酸第三丁酯13g中，於室溫攪拌下滴入三 氟乙酸5ml。在室溫繼續攪拌3〇分鐘後，於減壓下餾去溶 314918 626 200407073 劑，在殘留之油狀物質中加入乙酸乙酯5 〇ml，用飽和碳酸 氫鈉水溶液30ml及水3〇1111依次洗淨，用飽和食鹽水及無 水硫酸鎂依次脫水、乾燥後，於減壓下餾去溶劑。將殘留 物用矽膠管柱層析（其中用乙酸乙酯-己烷（1 ·· 4)溶出）精 製’得到為淡黃色結晶之目的物〇 4g。
熔點：78.0 至 83.0°C
Sd j-JT1;,δ7·85 (dd, J=9·0· 5·4Ηζ· 2Η)·7·3-7·35 2«·7·^ (· J 9·〇. 8.4Hz. 2Η), 6.71 (d, J=9. ΟΗζ, 1Η), 3.84 (bs, 2Η), 2.20 (s, 3Η). ν驟3 Ν -[4-[3-(4-敗苯基）_5-三氟甲基噚唑啉_ 5-基]-2-甲基苯基]_3”2_異丙基鄰苯二酸二醯胺之製造 在3-碘-N-異丙基酞醯胺酸〇35g之甲苯3〇mi溶液 中，於室溫授拌下，添加三氟乙酸針〇 28g，並於室溫檀 拌1 !阶於減壓下餾去溶劑後，將殘留物溶於乙腈1Μ， 於室溫攪拌下’滴入4_[3_(4_氟苯基)_5_三氟甲基_&quot;2_二 曙導5_基]_2_甲基苯胺〇34g之乙腈Μ丨溶液，並於同 溫度繼續授拌2小時。反應完結後，於減壓下餾去溶劑， 將殘留物用石夕膠管柱層析(其中用乙酸乙_'氯仿（1:3)溶 出)精製’得到為白色玻璃狀固體之目的物C 炫點：99·0 至 112.〇。〇
旧醜（CDC13，Me4Si，300_ δ8·49 (bs, 1Η) U 】=7.8Hz，ΙΗ), 7.87 (dd，J=8.7，5·做 2Η), 7.78 (d '4HZ，1H)，7·96 &lt;d， 7·1'7.25 (m 3H), 5.94 (d, M. 8Hz, 1H) 4l&gt;4 3 (nL iH)Z，^55 k 2H)· 卜6.6Hz，㈣. * 取1H)，2.38 (s，3H)，U6 (d， 合成例2 1 氧雜環戊烷-2-基]一 NM4-[4-(4-氯笨基）_5_三氟甲基^ 314918 627 200407073 2 -甲基苯基]-3-碘-N2-異丙基鄰苯二酸二醯胺（本發明化合 物7-03號） 步驟1 : 2-氯-1-(4·氯苯基）乙醇之製造 在4 -氯本曱酿曱基氯化物3.〇g之乙醇50m溶液中， 添加碳酸氫鈉1.5g，於冰冷攪拌下，滴入氫硼化鈉〇.3g懸 洋於水3ml之懸浮液，滴入終了後，於同溫度再繼續攪拌 1小日守。反應元結後’將反應混合物小心地注入1N鹽酸 100ml中並用乙酸乙酯萃取〇〇〇ml&gt;&lt; 2)，將有機層水洗後， 用無水硫酸鈉乾燥，並於減壓下餾去溶劑，得到為淡黃色 油狀物質之目的物2.5g。 麵（CDC13，Me4Si，300’（5 7.3-7·4 (¾ 4H)，4.88 (dd, J=8.6, 3.3Hz, 1H)，3.72 (dd, J=11.4, 3. 5Hz, 1H), 3.60 (dd, J=ll. 2, 8.6Hz, 1H), 2.70 (bs, 1H). 步驟2 : 4-[4-(4-氣苯基）-2-三氟甲基-13-二氧雜環戊烷_2_ 基]_2·曱基苯胺甲酸第三丁酯之製造 在合成例19之步驟丨合成之2_曱基三氟乙醯基苯 胺甲酸第三丁酯0.6g及2-氯-1-(4-氯苯基）乙醇0.3 8g之二 曱基亞楓5ml溶液中，於10°c攪拌下，小心添加6〇%油性 氫化鈉0.09g，並於室溫攪拌12小時。反應完結後，將反 應混合物注入100m水中，用乙酸乙酯萃取（1〇〇ηιιχ 2)，將 有機層水洗後’用無水硫酸鈉乾燥及於減壓下館去溶劑。 將殘留物用矽膠管柱層析（其中用乙酸乙酯_己烷（1 ·· 8)溶出） 精製’得到為黃色油狀物質之目的物〇.57g。 !H NMR (CDC13, Me4Si, 300MHz) 5 7.97 (d, J=8.4Hz, 1H), 7.52 (dd, J=9.5, 1.8Hz, 1H), 7.44 (bs，1H)，7. 15-7.35 (m’ 4H)，6.35 (bs, 1H)，5.40 (dd，J=8.5，6·4Ηζ，1H), 4.57 祖 J:8.1，6.0Hz，1H)，3.68 (t，H.他，1H)，2.29 (s，3H)· 1.54 (s，9H). 628 314918 200407073 基_1，3~二氧雜環戊烷-2- 步驟3 · 4-[4-(4 -氣苯基）-2-三氣曱 基]-2-甲基苯胺之製造 在4_[4_(4_氯苯基）_2_三氟甲基]，3_二氧雜環戊烧士 基]-2-甲基苯胺曱酸第三丁酯〇.5g中’於冰冷攪拌下滴入 三氟乙酸5ml。在室溫繼續攪拌3〇分鐘 里傻，於減壓下餾去 溶劑，在殘留之油狀物質中加入乙酸乙 0曰50m卜用飽和碳 酸氫鈉水溶液50ml及水5〇m!依次洗潘，田— 用無水硫酸鎂乾 燥後，於減麼下餾去溶劑。將殘留物用秒膠管板層析（其中 用乙酸乙酯-己烷(1 : 3)溶出)精製，得到為褐色油狀物質 目的物0.25g。 ' WNMR (CDC13, Me4Si, 300MHz) (5 7.3-7.4 (m，2H), 7.15-7.35 (m ⑽ β 加 1Η), 5.39 (dd, J=8.4, 6.4Hz, 1H), 4.55 (dd, j=8.0, 6 4Hz JH) ^ ^ ^8HZ， 1=8.4Hz, 1H), 2.20 (s, 3H). ， ，3·76 (bs，2H), 3.69 步驟4 : 氯苯基）-5-三氟曱基^，％二氧雜環戊 烷-2-基]_2_甲基苯基]_3_碘_n2_異丙基鄰苯二酸二醯衣 製造 在3-碘-N-異丙基酞醯胺酸〇.14g之曱苯1〇ml溶夜 中，於冰冷攪拌下，添加三氟乙酸酐〇.13g，並於室溫攪 拌30分鐘。於減壓下餾去溶劑後，將殘留物溶於乙腈見 10nU，於室溫攪拌下添加4_[心（心氯笨基）_2_三氟甲基_1 3 二氧雜環戊烷-2-基]-2-甲基苯胺O.lg，並於同溫度繼續攪 摔12小時。反應完結後，於減壓下餾去溶劑，將殘留物用 石夕膠管柱層析（其中用乙酸乙酯-己烷（1 : 2)溶出）精製，得 到為白色結晶之目的物〇.14g。 熔點：112·〇至mot 314918 629 200407073 ，H NMR (CDC]3i Me4Si, 300MHz) δ 8.38 (bs, 1H), 8.17 (d, J=8.8Hz, 1H), 7.99 (d, J=7.9Hz, 1H), 7.83 (d. J=7. 5Hz, 1H), 7.55 (d, J=8.6Hz, 1H), 7.50 (bs, 1H), 7.15-7.35 (瓜 5H), 5.7-5.9 (m，1H)，5.42 (dd，J:8.1，7.1Hz, 1H)，4.59 (dd，J=7.9，7.1Hz, 1H), 42-4.35(ni，lH)，3.70(t，J=8.4Hz，m)，2.37(s，3H)，1.19(d，J=6.6Hz，6H)· 合成例22 3- 碘-N2-異丙基-N1-[2-甲基-4-(2-苯基-4-三氟曱基-3,4-二 氫-2H-吡咯-4-基）-苯基]鄰苯二酸二醯胺（本發明化合物7_ 〇4號） 步驟1 : 2-甲基-4-(2-苯基-4-三氟甲基-3,4_二氫-2H-吡咯- 4- 基）苯胺曱酸第三丁酯之製造 在合成例1之步驟1至步驟2中合成之2-甲基-4-( K 二氟甲基乙烯基）苯胺甲酸第三丁酯3.0g之甲苯5〇ml溶液 中’添加異氰化苄基〇.78g及氧化亞銅0 03g，並於加熱回 流下攪拌1 0小時。反應完結後，將反應混合物注入i 〇〇如 水中並用乙酸乙酯萃取（l〇〇mlx 2)，將有機層用水洗後， 用無水硫酸鈉乾燥，並於減壓下餾去溶劑。將殘留物用矽 膠管柱層析（其中用乙酸乙^己郎：5)溶出）精製，得到 為赤褐色樹脂狀物質之目的物Ug(非對映異構物混合 (m, 1H), 1H), 3.19 1.53 and H NMR (CDCl, Me4Si, 300MHz) 5 8.05 and 8.04 (d, J=12.3Hz, 1H) 7 r, •15 乂 4 (m，7H)，6.30 (d，】=9·2Ηζ, 1H)，5.40and5.00 (td ；r：39： J=13*9i 1HK η&quot;·4&quot;1Η)* 步驟2 : 2-曱基-4-(2-苯基-4, 基）-苯胺之製造 在2-甲基-4-(2-苯基-4' 二氟甲基-3,4 -二 氟曱基-3,4-二氫_2丑_吡咯-4, 314918 630 200407073 基）-笨胺曱酸第三丁能〇7g中 酸1 0ml。在室溫繼續攪拌i 於冰冷攪拌下滴入三氟乙 在殘留之油狀物質中加入7小時後，於減壓下餾去溶劑， 水溶液50ml及水5〇ml# / §曰50m1，用飽和碳酸氫鈉 於減壓下餾去溶劑。將殘留乎，用無水硫酸鈉乾燥後， 乙酯-己烷（1 : 2)溶出）精製&quot;曰用矽膠官柱層析（其中用乙酸 的物0.26g。 衣，侍到為赤褐色樹脂狀物質之目 ]H NMR (CDC13, Me4Si, 300MHz) 6 8.05 (d j. 2H), 6.66 (d, J=9.0Hz, 1H), 4.95-5, 〇5 ^ 2H)，7* 25~7·4 4H), 7.05-7.1 (ia 7·0Ηζ，1H)，2.30 (dd，J=13.2，9 3HZ ^ 1H)，3·71 (bs，2H), 2·83 (dd，J=13 2 ,仰’ ：17 (s， ’ 步驟3 : 3-碘-N2-異丙基·Ni · 甲基- 4-(2 -苯基-4-三i甲其 _3,4-二氫必吼略-4·基）一笨基]鄰苯二酸二醯胺之製造土 在HN_異丙基駄醯胺酸〇.24g之甲* 15ml溶液 中，於冰冷授拌下，添加三氟乙酸奸〇23g ’並於室溫搜 摔！小時。於減壓下館去溶劑後，將殘留物溶於乙腈Hi 於室溫攪拌下添加2-甲基-4-(2-苯基三氟曱基_3 4_二气 -2H-吡咯-4-基）苯胺0.15g，並於同溫度繼續攪拌12小時^ 反應完結後，於減壓下餾去溶劑，將殘留物用矽膠管柱層 析（其中用乙酸乙酯-己烷（1 : 1)溶出）精製，得到為白色結 晶之目的物〇.〇9g。
熔點：118.0 至 120.(TC *HNMR (CDC13, Me4Si, 300MHz) 5 8.46 (bs, 1H), 8.0^.1 (m, 2H), 7.95 (d J=7 PH7 仙，7.76 (d，J=7. 7Hz，1H)，7. 15-7.4 (m，8H)，6. 10 (d，J=7 5Hz, 1H), ’ 1H), 4.2-4.3 (m, 1H), 2.86 (dd, J=13.2, 7.1Hz, 1H), 2.3-2.4 da 1H), 2 35 (s m ]· 18 (d, J=6. 6Hz, 6H). (s, 3H)&gt; 合成例23 314918 631 200407073 N [4_(3 -氰基苯基三氟甲基_4,5·二氫咲喃_5_基 甲基苯基卜3-碘-N2-異丙基鄰苯二酸二醯胺（本發明化合物 4-01 號） 步驟1 : 4-(3-氰基-2-苯基-5-三氟曱基-4,5- _2_曱基苯胺曱酸第三丁酯之製造
在合成例1之步驟1至步驟2中合成之2-甲基-4-( K 二氣曱基乙烯基）苯胺曱酸第三丁酯l.〇g及苄醯基乙腈 0.96g之乙酸45ml溶液中，於10(rc及攪拌下，小心添加 三乙酸錳二水合物2 67g，並於加熱回流下再攪拌2小時。 反應完結後’於減壓下餾去溶劑，將殘留物投入1〇_水 中並用乙酸乙0旨萃取（100mlx2)，將有機層用水洗後，用 =硫酸鈉乾燥，並於減壓下餾去溶劑。將殘留物用石夕膠 其中用乙酸乙醋己烧（1:3)溶出）精製，得到為 &gt;火頁色結晶之目的物0.35g。 丈谷點· 4 6 · 〇至4 9.0 ^麵（CDCI3，MqSi，300MHz) δ8·0-8.05 (¾ 2H) 7 m 〇 3Η)· 7*36 (d, j.,6HZt 1H, ,3] (bs&gt; 1H)&gt; 6 39 (^8 (h^6Hz, 1H), ,45-,6 (, 3.47 (df J=15.4Hz, lH)t 2.29 (s, 3H), 1.52 (s, 9H). *77 M5.4Hz, 1H), v驟2 · 4-(3-氰基_2-苯基-5-三氟甲基_4 9田甘# 丨丞4,5一一虱呋喃-5-基） -2-甲基本胺之製造 ) 在氰基-2-苯基-5-三氟甲基-45 _ 9田貧# 土 4,5·—虱呋喃_5-基） 甲基本胺甲酸第三丁酯〇·27中， 於冰冷攪拌下滴入三 鼠乙I 5ml。在室溫繼續攪拌丨小時 #1 ^ Λ ^ ^ 於減壓下餾去溶 在夂遠之油狀物質中加入乙酸乙萨s η】 C酉曰50ml，用飽和碳酸 虱鈉水溶液5〇m】及水50ml依次洗淨， 人/尤乎，用無水硫酸鈉乾 314918 632 200407073 後，於減壓下餾去溶劑， 0.15g。 得到為赤色樹脂狀物質之目的物 1H), 3.78 δ 8* 05 (m, 2H), r8 吡 2H), 3.74 (c ]n NMR (CDCI3, Me4Si, 300ΜΗζ) δ 2Η), 6.70 (dt J=9. ΟΗζ, 1H), 3.78 1H), 2.19 (s, 3H). 、7.45-7.55 (οι 3H), 7. 15-7.25 (m， W. J=15. 2Hz, 1H), 3.47 (d, J=15. 2Hz, 三氟甲基-4,5-二氫咲喃-
步驟3 ·· N】-[4-(3-氰基-2-苯基_5_ 5-基）-2-甲基苯基]異丙^ 呋喃-5-基）-2-甲基苯胺〇.lg，並於同溫度繼續攪拌12小 時。反應完結後，濾取析出之固體，用乙腈5ml洗淨，得 到為白色結晶之目的物〇. 〇 7 g。
熔點：214.0 至 215.0°C 丨OMR (CDC13, Me4Si，300MHz) δ8·42 (bs, 1H)，8.23 (d，JL，1H) 80一8! (m 7.95-8.0 (m, 1H), 7.8-7.85 (m, 1H), 7.45-7.6 (m, 3H), 7.35-7.45 (m, 2H) 7 2 7 3 ( 1H). 5.75 (d. J=8.1Hz, 1H). 4.15-4.3 (π, 1H), 3.80 (d, M5.4Hz, 1H) * 3 40 ! J=15.4Hz, 1H), 2.38 (s, 3H), 1.17 (d, ]=6. 6Hz, 6H). ’ ’ 合成例24 N】-[4-[6-(4-氯苯基）-2-甲基-4-三氟甲基-3,4_二氫嘧啶_心 基]-2 -甲基苯基]-3-峨-N2-異丙基鄰笨二酸二酿胺（本發明 化合物8 - 0 1號） 步驟1 : ‘[6-(4-氯苯基&gt;2-曱基-4-三氟曱基·3,4_二氫嘧啶 ••心基]-2-曱基苯胺甲酸第三丁酯之製造 在合成例18之步驟1至步驟3中合成之心[3_(4、氯笨 314918 633 200407073 基）-3-@同基-1-三氣甲某而祕f 匕 貺T丞i丙烯基μ2-甲基苯胺甲酸第三丁 @曰l.Og之乙醇5〇πι1溶液中，、夭丄 π 添加乙脒鹽酸鹽〇.4g及甲氧 化鈉2.3g，並於加熱回流下加熱攪拌$小時。反應完結後， 於減壓下館去溶劑，在殘留物中加人5_水並用乙酸乙 醋萃取（5_Χ2)’將有機層用飽合食鹽水及無水硫酸鎂依 人脫水及乾煉後’於減壓下餾去溶劑。將殘留物用矽膠管 柱層析（其中用乙酸乙酷-己烧（1 : υ溶出）精製，得到為無 色樹脂狀物質之目的物〇. 7 g。 iHMR (CDC13，Me4Si，300MHz) ¢5 7.3-7·9 (m 7H) (he m、。 ^ 1H). 2.26 (s, 3,. ,22 (s, 3H). 1. 51'«s 9H) ^，H，' &quot; 26 ^ Ιίΰ· 5&quot;29 二氟曱基-3,4-二氫嘧啶 步驟2 : 4_ [6-(4-氯苯基）-2-甲基-4_ 基]-2 -甲基苯胺之製造 在4-[M4_氯苯基）_2.甲基_4_三氣甲基_3,4_二氯射_ 4-基]-2-甲基苯胺甲酸第三丁醋〇.5g中，於冰冷攪拌下滴 入三氣乙酸3ml。在室溫繼續攪拌i小時後，於減壓下餾 去溶劑，在殘留物中加入水30ml並用乙酸乙酯萃取（3〇mi X 2)，將有機層用飽和碳酸氫鈉水溶液3 〇ml &gt; 序'後，用飽 和食鹽水及無水硫酸鎂依次脫水及乾燥後，於減芦 I T田 'itr &gt;谷劑’付到為無色樹脂狀物質之目的物〇. 4 g。 'HMR (CDC13, Me4Si, 300MHz) 0 7.48 (d, J=8.5Hz, 2H), 7.37 (d, 1=8. 5HZ (m，3Hh 6.65 (d，J=8.0Hz, 1H)，5.34 (s，1H)，3·40 (bs, 2H) 2 20 (\Γ)’ 7.2一7.3 3H). ， 、s，2. 17 (s, 步驟3 ·· NL[4-[6-(4-氣苯基）-2-曱基-4-三氟甲基一氣 嘴咬·4-基曱基苯基]-3-碘-N2-異丙基鄰笨二酸二隨胺&amp; 之製造 &quot; 314918 634 200407073
N /、丙基酞酿胺酸〇.4g之甲笨1〇mU 於冰冷攪拌下，添加二 τ —虱乙I酐0.4g，並於室溫攪拌3〇 …於減壓下餾去溶劑後，將殘留物溶於乙腈_，添 力“例4-氯苯基）-2_甲基_4_三敗甲基_3,4_二氫^_4基] -2-甲基苯胺0.4g’並於室_ 5小時。反應完結後，於 減麼下館去溶劑，將殘留物用石夕膠管柱層析(其中用乙酸乙 醋-氯仿ο: υ溶出)精製，得到為無色結晶之目的物。 熔點·· 137.0 至 139.0。(： Ή 腿（CDC13，Me4Si，300ΜΗζ) δ 8 37 (bs IH) 7 q » π / 〇 5·33 (S' 1H)· ^-32 (，3H), ,23 (, 3H), , 17 合成例25 N _[4-(2,2-一氯-i-(4_氯苯基）環丙基甲基苯基卜3_碘_ N2-(l-甲基-2-甲硫乙基）鄰苯二酸二醯胺（本發明化合物9 020 號） 步驟1 ·· 4、氯-3-甲基-4-硝基二苯酮之製造 在3-甲基-4-硝基苯甲酸50.0g之氯苯i〇0ml懸浮液中 添加亞硫醯氣30.2ml及N，N_二甲基曱醯胺imi，並於95 C攪拌1 · 5小時後，於減壓下餾去過剩之亞硫醯氣。在反 應混合物中加入氯苯30ml，於冰冷攪拌下，小心地加入氯 化鋁44.0g，繼而於80°C繼續攪拌2小時。反應完結後， 將放冷至室溫之反應混合物注入冰水5 0 〇 m 1中，再加入濃 鹽酸5 0 m 1後，用乙酸乙g旨萃取（1 5 0 m 1X 2)。將有機層用水 洗後’用飽和食鹽水及無水硫酸鎮依次脫水及乾燥後，於 減壓下餾去溶劑，將殘留之固體用二異丙醚洗淨，得到為 635 3149]8 200407073 淡黃色結晶之目的物6 3.5 g。 熔點：105.0 至 l〇7.5t： 7.65-7.8 (m, 4H), 7.50 (d, WNMR (CDC13，Me4Si, 300MHz) 0 8.04 (d，J=8lHz 仙 J=8.7Hz，2H)，2.66 (s，3H)· ’ · ’ 步驟2 : 4-胺基氯甲基二苯酮之製造 在4 _氣-3-曱基硝基二苯酮22〇g之乙酸乙酯 2 2 0ml，谷液中，加入乙酸22〇ml，水22〇mi及鐵粉％ ， 並於加熱回流下攪拌4.5小時。反應完結後，將反應混合 物用矽藻土過濾，並於減壓下餾去溶劑。將殘留物溶於 200ml乙酸乙酯中，並用飽和碳酸氫鈉水溶液2〇〇ml洗淨， 將有機層用飽和食鹽水及無水硫酸鎂依次脫水及乾燥後， 於減壓下餾去溶劑。將殘留物從二異丙醚中結晶，得到為 黃色結晶之目的物16.5g。
熔點：113.0 至 115.5°C 步驟3 · N-第二丁氧羰基(扣氯苄醯基）_2_甲基苯胺甲酸 第三丁酯之製造 在4-胺基-4、氯-3 -甲基二苯酮42 5g之N，N-二甲基甲 fe胺500ml溶液中，添加二碳酸二第三丁酯1〇5 〇g及碳酸 鉀72·0g，並於1〇〇 c攪拌3小時。反應完結後，放冷至室 溫，注入500ml冰水中並用乙酸乙酯萃取（35〇mlx 2)。將 有機層水洗（3OOmlx 2 )後，用飽和食鹽水及無水硫酸鎂依 次脫水、乾燥，並於減壓下餾去溶劑。將殘留物在己烷中 636 314918 200407073 結晶化，得到為白色固體之目的物7〇 〇g !HNMR (CDC13, Me4Si, 300MHz) 5 7.74 1H), 7.47 (d, M.OHz, 2H), 7.20 (d, (d&gt; J=9.0Hz, 2H), 7.67 (s, 1H), 7.60 (d, J=8. 1Hz, J=8. 1Hz, 1H), 2.27 (s, 3H), 1.43 (s, 18H). 步驟4 · N_第三了氧幾基氯苯基）乙烯基]-2-甲基 苯胺甲酸第三丁酯之製造 在第三丁氧化鉀lO.lg之四氫呋喃3〇〇ml溶液中，添
加甲基二本基鳞淳、化物3 9 Ί C W 牛宍化物j2.1 5g，並於室溫攪拌3〇分鐘， 繼而滴入N-第三丁負錄其1尸rr 一〗虱叛基-4-(4-氣卞醯基）-2-甲基苯胺甲 酸第三丁酯20.05g之四氫呋喃5〇ml溶液，並於同溫度繼 續再攪拌90分鐘。反應完結後，將反應混合物注入飽和氯 化銨水溶液200ml中，並攪拌15分鐘後，用乙酸乙酯i5〇mi 卒取。將有機層用飽和食鹽水及無水硫酸鎂依次脫水、乾 燥，並於減壓下餾去溶劑，將殘留物用矽膠管柱層析（其中 用乙酸乙酯-己烷（1 : 9)溶出）精製，得到為黃色油狀物質之 目的物19.0g。 nD213r 1. 5 3 9 8 7·1~7.15 (m, 2H), 7.04 (d, J=7.8Hz, 1-44 (s, 18H). 】HNMR (CDC13，Me4Si，300MHz) (5 7. 25-7. 35 (in, 4H) 1H), 5.46 (bs, lH)t 5.44 (bs, 1H), 2.18 (s, 3H), 步驟5-.N-第三丁氧幾基_4_[2,2_二氣-W4_氯苯基）環丙基] -2-曱基苯胺甲酸第三丁酯之製造 在N-第三丁氧羰基-4-[ 1-(4-氯笨基）乙烯基]·2_曱基笨 胺甲酸第三丁酯l.Og之氯仿5ml溶液中，添加十六烧基三 曱銨氯化物0.005g，於50°C攪拌下，滴入氫氧化鈉i 溶於水2ml之溶液。於同溫度繼續攪拌9〇分鐘後，用水 稀釋反應混合物，及用氯仿萃取（20mlx 2)。將有機層水洗 314918 637 200407073 (3Omlx 1)後，用飽和食鹽水及無水硫酸鎂依次脫水、乾 燥，並於減壓下餾去溶劑，得到為黃色油狀物質之目的 (d, (s， !Η NMR (CDC13, Me4Si, 300ΜΗζ) δ 7.41 (d，&gt;8· 4Hz, 2H)，7_ 25-7· 3 (m,仙，7 〇 J=8.7Hz, 1H), 2.30 (d, 1=7.2Hz, 1H), 2.22 (d, J=7.2Hz, 1H), 2.17 (s, 3H), } ^ 步驟6 : 4-[2,2-二氣-1-(4-氯苯基）環丙基]-2-甲基笨胺 造 在N-第三丁氧羰基-4-[2,2-二氯-1-(4-氯苯基）環丙基] -2-甲基苯胺甲酸第三丁酯1 .〇g中，於室溫攪拌下，滴入 三氟乙酸4ml。在同溫度繼續攪拌丨5分鐘後，於減壓下鶴 去過剩之三氟乙酸，將殘留之油狀物質溶於3〇ml之乙酸 乙酉旨中，並用飽和碳酸氫鈉水溶液20ml洗淨。將有機層 用飽和食鹽水及無水硫酸鎂依次脫水、乾燥，並於減壓下 餾去溶劑，得到為綠色油狀物質之目的物〇.6g。
證 〇Cl3, Me4Si，300_ δ7.39 (d，K 服，2Η)，7·26 (d，卜6他 2H 15 ta, 2H), 6.60 (d, M.7Hz, 1H), 3.26 (bs, 2H), 2.23 (d, M. 1Hz 1H) 2 17 (d 1Hz，1H)，2.13 (s，3H). ' 17 (d' 步私7 · N -[4-(2,2-二氯-1-(4-氣苯基）環丙基）_2_甲基苯基] -3-碘-N2-(l-曱基-2-曱硫乙基）鄰苯二酸二醯胺之製造 在3-硬-N-(卜甲基-2-曱硫乙基）酞醯胺酸〇4g之甲苯 l〇m丨溶液中，於室溫攪拌下，滴入三氟乙酸酐。於同 溫度攪拌15分鐘後，於減壓下餾去溶劑，將殘留物溶於乙 腈2ml’並滴入4-[2,2-二氯-1气心氯笨基）環丙基]_2_甲基苯 胺〇.35g之乙腈3ml溶液中。於室溫繼續攪拌3〇分鐘後， 將反應混合物冰冷，濾出析出之固體，用少量乙腈洗淨， 314918 638 200407073 得到為白色結晶之目的物〇. 5 g。 炼點：223.5 至 225.0t： lHNMR (CDCl, Me.Si, 300MHz) 6 8.23 (bs, 1H), 8.09 (d, J^8. 1Hz, lH), 7.95 (d, J=7.8Hz，1H)，7.75 (d, J=7.5Hz，1H), 7.41 (d，J=8·他，2H)，7·15-7.35 (¾ 5H)，6.13 (d· J=8.7Hz, 1H), 4.25-4.35 (m, 1H), 2.58 (dd, J=13.5, 4.5Hz, 1H), 2.50 (dd, J=13.5, 6*3Hz, 1H), 2.29 (s, 3H), 2.28 (d, J=7.2Hz, 1H), 2.23 (d, J=7. 2Hz, 1H) 1 83 (s 3H) L 23 (d，卜6, 6Hz, 3H). ’ · ’ ’ 合成例26 &gt;^-[4气2,2-二氟-1-(4-氯苯基）環丙基）-2-甲基笨基卜3-碘_ N -(1-曱基-2-曱硫乙基）鄰苯二酸二酸胺（本發明化合物9_ 〇 19 號） 步驟1 : 4-[2,2-二氟-1-(4-氯苯基）環丙基]-2-甲基苯胺之製 造 在合成例25之步驟1至步驟4合成之N-第三丁氧幾 基- 4- [l-(4 -氯苯基）乙稀基]-2-甲基苯胺甲酸第三丁酉旨i.7g 之二聚乙二醇二甲醚5ml溶液中，於170°C及攪拌下，經 30分鐘逐次少量添加二氯氟乙酸鈉7.Og，添加終了後，於 1 8 0 C再繼續揽掉3 0分鐘。反應完結後，放冷至室溫，將 反應混合物溶於乙酸乙酯50ml中並用水洗（5Omlx 1)，用 飽和食鹽水及無水硫酸鎂依次脫水及乾燥後，於減壓下鶴 去溶劑。在室溫及攪拌下，於殘留物中滴入三氟乙酸 10ml，然後於同溫度再繼續攪拌15分鐘。反應完結後， 於減壓下餾去過剩之三氟乙酸，將殘留之油狀物質溶於乙 酸乙酯30ml中，用飽和碳酸氫鈉水溶液20ml洗淨。將有 機層用飽和食鹽水及無水硫酸鎂依次脫水及乾燥後，於減 314918 639 200407073 ^ 去'合制’將殘留物用高速液體層析（其中用乙腈-水 )溶出）精製’得到為淡黃色油狀物質之目的物 0.35g 〇
21. ：\V 1.5 7 2 6 ^ (d· J=a7Hz· 2H)&gt; 7·24 (d· J-8·7»2· 2H)· 7.0- 牛 ，卜8.7HZ，m)，3.53 (bs，2H), 2·Π (s，310, 1.9-2.05 2Η)· / . · w^2,2-二氟氯苯基）環丙基]-2-甲基苯基] 3碘-N -(1-甲基甲硫乙基）鄰苯二酸二醯胺 在3-碘-Ν·(1-甲基_2-甲硫乙基）酞醯胺酸之甲苯 =ml /合液中，於室溫授掉下，滴入三氣乙酸肝〇 ^。於同 溫度攪拌15分鐘後，於減壓下餾去溶劑，將殘留物溶於乙 腈2ml’並滴入4-[2,2-二氟]_(4_氯苯基）環丙基]_2_甲基苯 胺0.2g之乙腈5ml溶液中。於室溫繼續授掉2小時後，將 反應混合物冰冷，濾出析出之固體，用少量乙腈洗淨，得 到為白色結晶之目的物0.32g。
熔點：229.0 至 232.0°C lH NMR _3, _，30_ δ8.26 (bs，拙， 1H), ,T4 (d. M.5H, , 22 (d ^ Γ',H 4 4-35 (m, 1H). 2.61 (dd, J=13.5, 6.0Hz, 1H). 2.52 (dd, J-13.5 6 3Hz 1H) ( 3H), 1,95-2.15 (in. 2H), 1.88 (s, 3H), 1.25 (d, J=6.6Hz, 3H). ’ ，，二 合成例27 N -[4-(2,2-一氟-l-(4-氯苯基）環丙基）_2_甲基笨基]_3_埃_ N2-(レ曱基-2-甲磺醯乙基）鄰笨二酸二醯胺（本發明化合'物 9-036 號) 在合成例26合成之二氟]-(4_氯苯基）環丙 基甲基苯基]-3-碘甲基甲硫乙基）鄰笨二酸二 314918 640 200407073 酿胺（本發明化合物9-019號）〇.15g之二氣甲烷20ml溶液 中’於冰冷授拌下，添加3 -氯過苯甲酸0.12g，並於室溫 ’擅;掉4 · 5小時。反應完結後’將反應混合物用亞硫酸 氫鈉水溶液30ml及飽和碳酸氫鈉水溶液30ml依次洗淨 後’用飽和食鹽水及無水硫酸鎂依次脫水及乾燥後，於減 壓下館去溶劑，得到為無色樹脂狀物質之目的物〇. 1 5 g。 旧醜（CDCI3，Meji，300MHz) &lt;5 8.26 (bs，1H)，7.80 (d, J=7.8Hz，1H), 7· 74 (d， J=9.0Hz, 1H), 7.55 (d, M.5Hz, 1H), 7.05-7.35 (m, 7H), 6.94 (d, J=7.5Hz, 1H), 4.4-4-5 1H), 3.24 (dd, 1=14.1, 4.2Hz, 1H), 3.00 (dd, J=14. ], 6.9Hz, 1H), 2.52 (s, 3H)» 2.23 (s, 3H), L 95-2. 15 (m, 2H), 1.41 (d, J=6. 3Hz, 3H). · 合成例2 8 ^-[4-(2,2-二氰基_1-三氟甲基環丙基）-2-甲基苯基]_3_埃_ N2-異丙基鄰苯二酸二醯胺（本發明化合物9_〇〇i號） 步V 1 · 4-(2,2-二氰基-1-三氟曱基環丙基）_2 -曱基苯胺甲 酸第三丁酯之製造 在合成例1之步驟1至步驟2合成之2_甲基_4_(1_三 敦甲基乙烯基）苯胺甲酸第三丁醋2.0g之氣仿50ml溶液' 中於至溫攪拌下，滴入溴〇.34ml，並於同溫度繼續攪拌 15分鐘。反應完結後，於減壓下餾去溶劑，得到粗製之 4-(2,2-二溴-卜三氟曱基乙基）_2_甲基苯胺甲酸第三丁酯。 繼而，在懸浮於曱苯3ml之第三丁氧化鉀〇75g中，=室 溫及攪拌下，滴入丙二腈〇.5g之甲苯5mi溶液，並於同溫 度攪拌1小時，然後滴入粗製4_(2,2_二溴_丨_三氟曱基乙基） _2\甲基笨胺甲酸第三丁自旨之甲笨5ml溶液並繼續^拌。土^ 小時後追加第三丁氧化鉀1.5g ’並再繼續攪拌4小時。反 314938 641 200407073 應完結後，將反應混合物用稀鹽酸3〇ml洗淨後，用飽和 食鹽水及無水硫酸鎂依次脫水及乾燥後，於減壓下餾去溶 钟J °將殘留物用矽膠管柱層析（其中用乙酸乙酯-己烧（1 : 4) /谷出）精製，得到為白色結晶之目的物丨.丨5 g。
、熔點：179.5 至 182.0°C H NMR (CDC13, Me4Si, 300MHz) 0 8.08 (d, J=8.7Hz, 1H), 7.25-7.3 (m, 2H), 6.41 (bs, 1H)，2.59 (d，J=6.9Hz，1H)，2.39 (d，J=6.9Hz，1H)，2.29 (s，3H)，1,53 (s，9H). 2· 4-(2，2-二氰基_1-三氟甲基環丙基广2_曱基苯胺酯 之製造 在4-(2,2-二氰基-1-三氟曱基環丙基）-2_甲基苯胺甲酸 第三丁酯1.05g中，於室溫攪拌下，滴入三氟乙酸5ml。 在至’服％續授拌1小時後，於減壓下鶴去溶劑，將殘留物 /合於乙g文乙酯50ml中並用飽和碳酸氫鈉水溶液3〇mi洗淨 後，用飽和食鹽水及無水硫酸鎂依次脫水、乾燥，並於減 壓下餾去溶劑，得到為褐色樹脂狀物質之目的物〇.78g。 «Η 2. 麵復13，Me4Si，300_) δ7. 11 (bs 2Η) fi 7Π Ιά 7u …、 rr M 0lT zh), b. iU (d, J~8./Hz, 1H), 3.07 (bs, 2H) (d，J-6.3Hz，1H)，2. 3-2.4 (m，1H)，2. 18 (s, 3H). 步驟3· N -[4-(2,2-二氰基三氟甲基環丙基）甲基苯基] -3-埃-N2-異丙基鄰苯二酸二醯胺之製造 在3-碘-N-異丙基酞醯胺酸〇.27g之甲笨溶液中， 方、至服攪拌下，添加二氟乙酸酐〇 2g，並於室溫攪拌Μ 分鐘。於減壓下餾去溶劑後，將殘留物溶於 加一氛基-1-三氣甲基環丙基”_甲基笨二… 腈5ml溶液，並於室溫攪拌2小時。反應完結&amp;，於減壓 314918 642 200407073 下館去溶劑’將殘留物用石夕膜管 岭&amp;柱層析（其中用乙酸乙酯- 己烧（1 : 1)溶出）精製，得到為 j馮白色結晶之目的物〇.2g。 熔點：218.0 至 221.0。(： Ή 臟（CDCU MqSi，300_ δ 8.52 (bs η。 J=8.1Hz, IH), 7.77 (d, M.2HZ, 1H), 7.15-7.35 im 3H) 5 q/m 4 3 (m, 1H)，2.62 (d, J=6.6Hz，1H)，2.35-2 5 (m ih) 2 38 ( q’ 】一8. 1HZ，鼠 4.卜 6H). Z.b (m，1H)’ 2.38 (s，細，U3 (q，J=6.6Hz， 合成例29
Nl_[4_[4_(4_氯苯基）_2_三氣甲H,3_氧雜四氯嚷吩_2_基卜 2曱基苯基]3蛾-N-異丙基鄰苯二酸二醯胺（本發明化合 物7-09號） 步驟1: 2-(4-氣苯基）·2-(3_甲基U肖基苯基）―丨^氧雜四氫 噻吩之製造 在合成例25之步驟1合成之4，_氣_3_甲基_心硝基二苯 ’ l.Og及2-氫硫基乙醇51111之氣乙烷^丨溶液中， 添加氣三甲基矽烷2.0g，並於6(rc攪拌3·5小時。反應完 結後，將反應混合物注入50ml水中並用氯仿萃取（3〇mlx 2)，將有機層水洗後，用飽和食鹽水及無水硫酸鈉依次脫 水、乾燥，並於減壓下鶴去溶劑，得到為黃色油狀物質之 粗製目的物1.4g。將其於未精製下，用於下一反應。 步驟2: 4-[2-(4-氣苯基）-i，3-氧雜四氫噻吩基]_2_曱基苯 胺之製造 在粗製之2-(4-氣笨基）-2-(3-曱基-4-硝基苯基）-1，3-氧 雜四氫噻吩1.4g及氣化亞銅1 〇8g懸浮於1⑽mi甲醇之懸 浮液中，於室溫及攪拌下，經3 0分鐘逐次少量添加氫硼化 643 314918 200407073 卸1.3 7g。於同溫度繼續攪拌1小時後，經3〇分鐘逐次少 量添加氧化亞銅1〇8g及氫硼化鉀137g，並於同溫度二 撸牲〇 » 士 、匦、， 、 、日守。反應完結後，經石夕藻土過濾，除去不溶物， 並於減壓下餾去溶劑。在殘留之油狀物質中加入乙酸乙鲳 5〇ml ’並用稀氨水5〇mi洗淨，然後用飽和食鹽水及無水 石度酸鈉依次脫水、乾燥，並於減壓下餾去溶劑。將殘留物 用矽膠管柱層析（其中用乙酸乙酯_己烷（1 : 2)溶出）精製， 得到為黃色油狀物質之目的物〇.2g 。 IH^(CDCl3，Me4Si，30()_c5 7.43 (d，J=8.4,2H)，7.05-7.3(ia4H),6.58((1 4Hz, 1H), 4.15-4.2 (m, 2H), 3.63 (bs, 2H), 3.2-3.25 (m, 2H), 2.13 (s, 3H) 步驟3 : N1-[4-[2-(4-氣苯基）-1，3-氧雜四氫噻吩_2-基]-2 -甲 基本基]-3-碳-N2-異丙基鄰苯二酸二酿胺之製造 在3-碘異丙基酞醯胺酸（K3g之曱苯5ml溶液中， 於至稅掉下’滴入二氟乙酸昕〇 · 2 3 g，並於同溫度擾掉 1 5分鐘。於減壓下餾去溶劑後，將殘留物溶於乙腈2ml， 於至溫及攪拌下，添加4-[2-(4-氣苯基）-i，3-氧雜四氫噻吩 -2-基]-2 -甲基苯胺〇.2g之乙腈5mi溶液，於同溫度繼續授 拌1小時。反應完結後，濾出析出之固體，用少量乙腈洗 淨，得到為白色結晶之目的物〇. 2 5 g。
熔點：213.5 至 217.0°C 】OMR(CDCl3，Me4Si，300MHZ)5 8.31(bS，lH)，7.9-8.0(ni，2H)，7.75(d，J:7.8HZ.lH&gt; 7.43 (d，J=8.7Hz，2H)，7.15-7.35 (m 5H)，5· 91 (d，J=7.8Hz, 1H)，4· 15-4.25 (m 3H) 3.2-3.3 (m, 2H), 2.28 (s, 3H), 1.17 (d, 1-6.6Hz, 6H). ’ 本發明化合物，可以依照上述製造法及實施例製造。 雖然將此等化合物之例子示於第8表至第24表中，但本發 644 314918 200407073 明不僅限於此。 又，表中Et表示乙基，以下同樣地，n-Pr或Pr-n表 示正丙基，i-Pr或Pr-i表示異丙基，c-Pr或Pr-c表示環丙 基，n-Bu或Bu-n表示正丁基，s-Bu或Bu-s表示第二丁基， i-Bu或Bu-i表示異丁基，t-Bu或Bu-t表示第三丁基，c-Pen 或Pen-c表示環戊基，c-Hex或Hex-c表示環己基，以及 Ph表示苯基。 在表中以L-la至L-47g表示之芳香族雜環，分別表示 下述之構造： L-la L - 3d:
Br L 一 14a: :-n5 L-36a： L-lc： L 一4a: L-23b ： L~45a：
L 一24a: L_3c:
L-4b： -o&quot;-o W5g：
L-451 : L-46m&quot;
L-47c L-46d
L-47e ：
645 314918 200407073 又，表中 指「分解」。 意指「樹脂狀」，* 2意指「油狀」及* 3意 第8表
646 314918 200407073
No. (X)m R2 R3 R4 R5 ep. (t：) 1-001 1-002 卜003 卜004 卜005 1-006 1-007 1-008 1-009 1-010 1-011 1-012 1-013 1-014 1-015 1-016 1-017 1-018 1-019 1-020 卜021 卜022 卜023 卜024 卜025 1-026 1-027 1-028 1-029 卜030 卜031 1-032 1-033 卜034
i-Pr i_Pr i-Pr i-Pr i-Pr i - Pr i-Pr i-Pr i - Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i-Pr i_Pr i-Pr i-Pr i-Pr i-Pr i-Pr ch3 ch3 206. 0-208. 0 ch3 Ph 113. 0-115.0 ch3 Ph 110. 0-112.0 cf3 Cl 217.0-219.0 cf3 Br 124. 0-126.0 cf3 ch3 236· 0-238. 0 cf3 ch3 186. 0-188.0 cf3 n-Pr 103. 0-105.0 cf3 i-Pr 104. 0-105.5 cf3 t-Bu 210. 0-212.0 cf3 c-Hex 116. 0-118.0 cf3 CH2C1 111.0-113.0 cf3 cf3 240. 0-242. 0 cf3 CH2Ph 88. 0-90. 0 cf3 0CH3 115. 0-117. 0 cf3 sch3 162.0-164.0 cf3 so2ch3 92. 0-94. 0 cf3 n(ch3)2 117. 0-119.0 cf3 C(0)0Et 163. 0-165.0 cf3 C(0) OEt 172. 0-174 0 cf3 C(0)Ph 137.0-139.0 cf3 Ph 103. 0-105.0 cf3 Ph 112. 0-114.0 cf3 L_lc *1 cf3 L-3c 143. 0-145.0 cf3 L-3d 239. 0-240. 0 cf3 L-4a 142. 0-143.0 cf3 L-4b ♦ 1 cf3 L-14a 121.0-123.0 cf3 L - 23b 117. 0-127.0 cf3 L - 24a 131. 0-132.0 cf3 L-36a 131. 0-133.0 cf3 L - 45a 115. 0-117.0 cf3 L - 46a 84· 0-86· 0
647 314918 200407073 1-035 3-1 Η 卜Ργ cf3 L-46d 108. 0-112.0 1-036 3-1 Η i，Pr cf3 L-46di 130. 0-131.0 1-037 3-1 Η i - Ργ cf3 L_47a 131.0-133· 0 1-038 3-1 Η 卜Ργ cf3 L-47c 77. 0-79. 0 1-039 3-1 Η 卜Ργ cf3 L-47e 196. 0-198.0 卜040 3-1 Η i-Pr CF 2 CF 2 CF 3 ch3 245. 0-246. 0 1-041 3-1 Η i-Pr C(CH3)=N0CH3 ch3 151· 0-154· 5 1-042 3-1 Η i-Pr C (CH3)=N0CH2Ph ch3 194. 5-197. 0 1-043 3-1 Η i-Pr Ph ch3 222. 0-224. 0 1-044 3-1 Η 卜Pr L-46d ch3 175. (Η 78. 0 1-045 3-1 Η CH (CH3)CH2SCH3 cf3 L-47a 104. 0-106. 0 1-046 3-1 Η c(ch3)2ch2sch3 cf3 Ph 104 0-107. 0 1-047 3-1 Η C(CH3)2CH2SCH3 cf3 L-lc 108. 0-109. 0 1-048 3-1 Η C(CH3)2CH2SCH3 cf3 L-3c 114. 0-115.0 1-049 3-1 Η C(CH3)2CH2SCH3 cf3 L - 3d 136· 0-138.0 1-050 3-1 Η C(CH3)2CH2SCH3 cf3 L-36a 102. 0-103· 0 卜051 3-1 Η c(ch3)2ch2sch3 cf3 L - 46d 111· (Η 13.0 卜052 3-1 Η C(CH3) 2CH2S(0)CH3 cf3 Ph 113. 0-119.0 1-053 3-1 Η C(CH3)2CH2S(0) ch3 cf3 L-3c 135. 0-136. 0 1-054 3-1 Η C(CH3)2CH2S02CH3 cf3 Ph 95. 0-99. 0 1-055 3-1 Η c(ch3)2ch2so2ch3 cf3 L-lc 127.0-129.0 1-056 3-1 Η C(CH3)2CH2S02CH3 cf3 L - 3c 129. 0-130.0 1-057 3-1 Η C(CH3) 2ch2so2ch3 cf3 L-3d 134. 0-136.0 1 - 058 3-1 Η c(ch3) 2ch2so2ch3 cf3 L - 36a 119. 0-121.0
第9表
648 314918 200407073
No. (X)m R2 R3 R4 (Z2)P1 E P. (t：) 2-001 H H l-Pr cf3 4-S02CH3 *1 2-002 3-F H i - Pr cf3 4-C1 *1 2-003 3-Br H i-Pr cf3 4-S02CH3 140. 0-143. 0 2-004 6-Br H i-Pr cf3 4-S02CH3 148. 0-151.0 2-005 3-1 H Et cf3 4~S02CH3 159. 0-165. 0 2-006 3-1 H n-Pr cf3 4-S02CH3 130.0-133.0 2-007 3-1 H i - Pr H 4-Cl 237. 0—239. 0 2-008 3-1 H i-Pr ch3 4-F 108. 0-112.0 2-009 3-1 H i_Pr ch3 4-C1 193. 0-194 0 2-010 3-1 H i-Pr Et 4-Cl 138.5-140.0 2-011 3-1 H i-Pr n-Pr 4-Cl 134. 0-136. 0 2-012 3-1 H i-Pr i-Pr 4-C1 127. 0-130.0 2-013 3-1 H i-Pr c-Pr 4-Cl 178. 0-180.0 2-014 3-1 H i-Pr cf3 2-F 112. 0-115.0 2-015 3-1 H i-Pr cf3 3-F 114 0-115.0 2-016 3-1 H i-Pr cf3 4~F 128. 0-130.0 2-017 3-1 H i-Pr cf3 2-C1 172. 0-174.0 2-018 3-1 H i-Pr cf3 3-C1 196· (Η98·0 2-019 3-1 H i-Pr cf3 4-C1 140. 0-142. 0 2-020 3-1 H i-Pr cf3 4-Br 134· 0-136· 0 2-021 3-1 H i-Pr cf3 4-1 148.0-150· 0 2-022 3-1 H i-Pr cf3 4-CH3 129. 0-131.0 2-023 3-1 H i-Pr cf3 4-Bu-t 147. 0-149. 0 2-024 3-1 H i-Pr cf3 4-CH2C1 120. 0-122.0 2-025 3-1 H i-Pr cf3 4-CF3 122. 5-128.0 2-026 3-1 H i-Pr cf3 4-CH2SCH3 113. 0-116.0 2-027 3-1 H i-Pr cf3 4-CH2S(0) CH3 158. 0-161.0 2-028 3-1 H i-Pr cf3 4-OCH3 134. 0-137.0 2-029 3-1 H i-Pr cf3 4-0CHF2 110. 0-111.0 2-030 3-1 H i-Pr cf3 4-0CF3 126. 0-129.0 2-031 3-1 H i-Pr cf3 4-0CF2CHFCF3 110. 0-114.0 2-032 3-1 H i-Pr cf3 4-0S02CH3 104. 0-106. 0 2-033 3-1 H i-Pr cf3 4-0S02CF3 138· 0-141.0 2-034 3-1 H i-Pr cf3 4 - OPh 119. 0-136.0
649 314918 200407073 2-035 3-1 Η i-Pr cf3 4-0 (L-451) 130. 0-134.0 2-036 3-1 Η 卜Ργ cf3 4-SCH3 134. 0-136.0 2-037 3-1 Η i-Pr cf3 4-S (0) CH3 134. 0-151.5 2-038 3-1 Η i - Pr cf3 4-S02CH3 257. 0-259. 0 2-039 6-1 Η 卜Pr cf3 4-SO2CH3 294. 0-296. 0 2-040 3-1 Η i-Pr CF3 4-S02Et *1 2-041 3-1 Η i - Pr cf3 4-SCF3 126. 0-128.0 2-042 3-1 Η i-Pr cf3 4-S(0)CF3 76. 0-78· 0 2-043 3-1 Η i - Pr cf3 4 - N02 145· 0-153. 0 2-044 3-1 Η i-Pr cf3 4-N (CH3)2 133. 0-137. 0 2-045 3-1 Η i-Pr cf3 4-NHS02CH3 *1 2-046 3-1 Η i-Pr cf3 4 - CN 132.0-135· 0 2-047 3-1 Η i-Pr cf3 4~C (0) 0CH3 *1 2-048 3-1 Η i-Pr cf3 4-C«))NH2 173.0-175.0 2-049 3-1 Η i-Pr cf3 4-Ph 135. 2-142.0 2-050 3-1 Η i-Pr cf3 2, 4-F2 117. 0-128. 0 2-051 3-1 Η i-Pr cf3 3, 4-F2 93. 5-98. 0 2-052 3-1 Η i-Pr cf3 2, 6-F 2 206. 0-210.0 2-053 3-1 Η i-Pr cf3 2-F-4-C1 124· 5M 28. 3 2-054 3-1 Η i-Pr cf3 3-F+C1 122. 0-127.0 2-055 3-1 Η i-Pr cf3 2,4_C12 135. 0-137.0 2-056 3-1 Η i-Pr cf3 2, 6~C12 138. 5-142. 5 2-057 3-1 Η i-Pr cf3 3, 4-Cl 2 129. 0-131.0 2-058 3-1 Η i-Pr cf3 3-CH-0CH3 125. 0-127.0 2-059 3-1 Η i-Pr CF2CF2CF3 4-Cl 155. 5Ί58. 5 2-060 3-1 Η i-Pr CF2CF2CF3 4-S02CH3 *1 2-061 3-1 Η i-Pr ch2och3 4-Cl 140. 5-143. 0 2-062 3-1 Η i-Pr Ph 4-Cl 151. 0-153. 5 2-063 3-1 Η c -Pr cf3 4-S02CH3 200. 0-203. 0 2-064 3-1 Η n-Bu cf3 4-S02CH3 126. 0-128.0 2-065 3-1 Η i-Bu cf3 4 - Cl 164· 5-166· 5 2-066 3-1 Η 卜Bu cf3 4-S02CH3 214.0-216· 5 2-067 3-1 Η s - Bu cf3 4 - Br 149· 5-152.0 2-068 3-1 Η s - Bu cf3 4-S02CH3 246. 5-249. 0 2-069 3-1 Η t - Bu cf3 4~S02CH3 266. 0-268. 0 2-070 3-1 Η CH2Pr-c cf3 4-S02CH3 85. 0-90. 0 2-071 3-1 Η CH(CH3)Pr - n cf3 4-S02CH3 141.0-143.5
650 314918 200407073 2-072 3-1 Η CH(Et)2 cf3 4 - SO 2 CH 3 127. 0-130.0 2-073 3-1 Η C(CH3)2Et cf3 4-S02CH3 261.0-263.0 2-074 3-1 Η c-Pen cf3 4-S02CH3 229. 0-232. 0 2-075 3-1 Η CH (CH3)Bu~i cf3 4-C1 125. 0-140.0 2-076 3-1 Η CH(CH3)BiH cf3 4-S02CH3 236. 0-239.5 2-077 3-1 Η c-Hex cf3 4~S〇2CH3 233. 0-235. 0 2-078 3-1 Η C(CH3)2CH2Bu -1 cf3 4-S02CH3 239· 0-240. 5 2-079 3-1 Η CH2CH2F cf3 4-S02CH3 191. 0-194 0 2-080 3-1 Η ch2ch2ci cf3 4-S02CH3 140. 0-142. 5 2-081 3-1 Η ch2cf3 cf3 4-S02CH3 249. 0-251.0 2-082 3-1 Η CH (CH3)CH2OCH3 cf3 4-Cl 116. 0-119.0 2-083 3-1 Η CH (CH3)CH20CH3 cf3 4-Br 118. 0-121.0 2-084 3-1 Η CH (CH3)CH2OCH3 cf3 4-S02CH3 234· 0-236. 0 2-085 3-1 Η ch(ch3)ch2oc(o)nhch3 cf3 4-S02CH3 143.5-145. 0 2-086 3-1 Η CH(CH3)CH20C(0)NHEt cf3 4-C1 133. 0-136.0 2-087 3-1 Η CH(Et) CH2OCH3 cf3 4-S02CH3 ♦ 1 2-088 3-1 Η c(ch3)2ch2oh cf3 4-C1 134. 0-155.0 2-089 3-1 Η C(CH3)2CH2OH cf3 4-S02CH3 157. 0-178.0 2-090 3-1 Η C(CH3)2CH2OC (0) cf3 cf3 4-S02CH3 132. 0-154. 0 2-091 3-1 Η C(CH3) 2CH2OC (O)OEt cf3 4-S02CH3 、 125. 0-140.0 2-092 3-1 Η CH (CH3)CH2SCH3 ch3 4-F 101.5-106.0 2-093 3-1 Η CH (CH3)CH2SCH3 ch3 4-Cl 169.5-175.0 2-094 3-1 Η CH (CH3)CH2SCH3 cf3 4-F 103.5-110.0 2-095 3-1 Η CH (CH3)CH2SCH3 cf3 4-C1 116.5-120.3 2-096 3-1 Η CH (CH3)CH2SCH3 cf3 4~Br 124.5-129. 5 2-097 3-1 Η CH (CH3)CH2SCH3 cf3 4-0CHF2 99. 0-104. 0 2-098 3-1 Η CH (CH3)CH2SCH3 cf3 4-OCF3 113. 5-120.5 2-099 3-1 Η CH (CH3)CH2SCH3 cf3 4-OCF2CHFCF3 114. 0-117.5 2-100 3-1 Η CH (CH3)CH2SCH3 cf3 4-0S02CH3 110. 0-116.0 2-101 6-1 Η CH (CH3)CH2SCH3 cf3 4-0S02CH3 121. 0-126.0 2-102 3-1 Η CH (CH3)CH2SCH3 cf3 4-0(L-451) 120. 0-124.5 2-103 3-1 Η CH (CH3)CH2SCH3 cf3 4-SCH3 *1 2-104 3-1 Η CH (CH3)CH2SCH3 cf3 4-S02CH3 120. 5-133.0 2-105 3-1 Η CH(CH3)CH2SCH3 cf3 4-NO 2 131· 5-144.0 2-106 3-1 Η CH (CH3)CH2SCH3 cf3 4 - CN 123.0-128.0 2-107 3-1 Η CH (CH3)CH2S(0) CH3 cf3 4_F 120.5-130.0 2-108 3-1 Η CH (CH3)CH2S(0) CH3 cf3 4-Br 134. 0-150· 0
651 314918 200407073 2-109 3-1 Η CH (CH3)CH2S(0) CH3 cf3 4-OCF3 126. 0-135.0 2-110 3-1 Η CH (CH3)CH2S(0) CH3 cf3 4-0S02CH3 133. 0-135. 0 2-111 3-1 Η ch(ch3)ch2s_3 cf3 4爲 142· 0-174. 0 2-112 3-1 Η CH(CH3)CH2S02CH3 cf3 4-F 114.0-124. 0 2-113 3-1 Η CH (CH3)CH2S02CH3 cf3 4-C1 140. 0-150.0 2-114 3-1 Η CH (CH3)CH2S02CH3 cf3 4-Br 138. 0-147. 0 2-115 3-1 Η CH (CH3)CH2S02CH3 cf3 4-0CHF2 . 116. 0-120.0 2-116 3-1 Η CH (CH3)CH2S02CH3 cf3 4-OCF3 123. 0-129.5 2-117 3-1 Η CH (CH3)CH2S02CH3 cf3 4-0S02CH3 137. 0-140. 0 2-118 3-1 Η CH (CH3)CH2S02CH3 cf3 4-0 (L - 451) 125. 5-131.0 2-119 3-1 Η CH (CH3)CH2S02CH3 cf3 4-S02CH3 154. 0-156.0 2 -120 3-1 Η CH (CH3)CH2S02CH3 cf3 4-NO 2 147.5-169. 0 2-121 3-1 Η CH (CH3)CH2S02CH3 cf3 4-CN 142· 0-146. 0 2-122 3-1 Η c(ch3)2ch2sch3 ch3 4-C1 106· 0-109. 0 2-123 3-1 Η c(ch3) 2ch2sch3 cf3 4-F 115.0-116.0 2-124 3-1 Η C(CH3) 2ch2sch3 cf3 4-C1 113. 0-115.0 2-125 3-1 Η c(ch3)2ch2sch3 cf3 4-Br 157.0-167.0 2-126 3-1 Η C(CH3)2CH2SCH3 cf3 4-0CHF2 97. 0-102.0 2-127 3-1 Η c(ch3) 2ch2sch3 cf3 4-0CF3 113.5-117.5 2-128 3-1 Η C(CH3)2CH2SCH3 cf3 4-SCH3 184 0-188.0 2-129 3-1 Η C(CH3)2CH2SCH3 cf3 4-S02CH3 131. 0-133.0 2-130 3-1 Η C(CH3) 2ch2sch3 cf3 4-N02 130. 5-146.0 2-131 3-1 Η C(CH3) 2ch2sch3 cf3 3, 4-Cl 2 186. 0-188.0 2-132 3-1 Η c(ch3)2ch2s(o)ch3 cf3 4-F 114. 0-134.0 2-133 3-1 Η C(CH3) 2CH2S(0) ch3 cf3 4-Br 130. 0-147.0 2-134 3-1 Η c(ch3)2ch2s_3 cf3 4-0CHF2 117. 0-122. 0 2-135 3-1 Η C(CH3) 2CH2S(0) ch3 cf3 4-OCF3 118.0 -1440 2-136 3-1 Η C(CH3) 2CH2S(0) ch3 cf3 4-N02 155.0-171· 5 2-137 3-1 Η C(CH3) 2ch2so2ch3 cf3 4-F 116.0-124 5 2-138 3-1 Η c(ch3)2ch2so2ch3 cf3 4-C1 108. 5-112.0 2-139 3-1 Η c(ch3)2ch2so2ch3 cf3 4-Br 117.0-137. 0 2-140 3-1 Η C(CH3) 2ch2so2ch3 cf3 4-0CHF2 215. 0-218.0 2-141 3-1 Η C(CH3)2CH2S02CH3 cf3 4-0CF3 124. 0-132.0 2-142 3-1 Η c(ch3)2ch2so2ch3 cf3 4-SCH3 205. 0-208. 0 2-143 3-1 Η C(CH3)2CH2S02CH3 cf3 4-S02CH3 143. 0-145.0 2-144 3-1 Η c(ch3)2ch2so2ch3 cf3 4-N0 2 140.0-161.5 2~14δ 3-1 Η c(ch3) 2ch2so2ch3 cf3 3, 4-Cl 2 141· 0-142.0
652 314918 200407073 2-146 3-1 H C(CH3) 2CH2NHC(0)0CH3 cf3 4-C1 120.0-121.0 2-147 3-1 H C(CH3) 2cn cf3 4-C1 283· 0-285.0 2-148 3-1 H C (CH3) 2cn cf3 4-S02CH3 &gt;300 (*3) 2-149 3-1 H CH(CH3)C(0)0CH3 cf3 4 - Cl *1 2-150 3-1 H CH(CH3)C(0)0CH3 cf3 4-S02CH3 *1 2-151 6-1 H CH(CH3)C(0)0CH3 cf3 4-S02CH3 *1 2-152 3-1 H CH(CH3)CH2C(0)0et cf3 4~C1 100.0-107. 0 2-153 3-1 H CH(CH3) CH2C(0)0et cf3 4-S02CH3 104 0-111.5 2-154 3-1 H CH2Ph cf3 4-S02CH3 209.0-210.5 2-155 6-1 H CH2Ph cf3 4-S02CH3 167.5-170.0 2-156 3-1 H CH2 (Ph-2~C1) cf3 4-S02CH3 135. 0-137.0 2-157 3-1 H CH(CH3)Ph-(R) cf3 4-S02CH3 150. 0-17Z 0 2-158 3-1 H C(CH3)2CH2Ph cf3 4-C1 115.0-117.0 2-159 3-1 H CH2 (Lrla) cf3 4-S02CH3 177.0 -181.0 2-160 3-1 H Ph cf3 4-S02CH3 193. 0-195. 0 2-161 3-1 Et Et cf3 4-C1 237.0-239.0 2-162 3-1 Et Et cf3 4-S02CH3 155. 0-157. 0 2-163 3-CF3 H i-Pr cf3 4 - Cl 251. 0-252· 0 2-164 3-CFa H i - Pr cf3 4-S02CH3 270. 0-272. 0 2-165 3-SCH3 H i-Pr cf3 4-S02CH3 127. 0-130. 5 2-166 3-S02CH3 H i - Pr cf3 4 爲 CH3 173. 0-175. 5 2-167 3 -N02 H i-Pr cf3 4-F 152. 0-153.0 2-168 3-N02 H i-Pr cf3 4 - Cl 210.0-114 5 2-169 3-N〇2 H i-Pr cf3 4-S02CH3 158.5-160.0 2-170 3 -NH2 H i-Pr cf3 4~F 122. 0-124 0 2-171 3爲 H i - Pr cf3 4-C1 *1 2-172 3~NHEt H i-Pr cf3 4-C1 132.5-134 5 2-173 3-NHEt H i-Pr cf3 4~S02CH3 137.5-140. 5 2-174 3-N(Et)C(0)CH3 H i-Pr cf3 4-C1 184. 0-187. 5 2-175 3-N(Et)C(0)CH3 H i-Pr cf3 4-SO2CH3 ♦ 1 2-176 3-N=C(CH3)0et H i-Pr cf3 4~C1 ♦ 1 2-177 3-N=C (CH3)0et H i-Pr cf3 4-S02CH3 ♦ 1 2-178 3-_CH2- i-Pr cf3 4 - Cl ♦ 1 2-179 3-N(Et)CH2- i-Pr cf3 4-S02CH3 *1 2-180 3-S(0)GH3 H i-Pr cf3 4-S02CH3 160. 0-163. 0 2-181 3-1 H CH(CH3) ch2so2ch3 cf3 4~0CF2CHFCF3 124 0-12&amp;5 653 314918 200407073 第ίο表
No. X R3 (Z2)P1 R5 E p. (*C) 3-001 I i-Pr 4 -F V. ch3 ♦2 3-002 I i-Pr 2-C1 ch3 190.0-192.5 3-003 I i-Pr 3-C1 ch3 187. 0-190.0 3-004 夏 卜Pr 4-C1 Cl 192. 0-194. 5 3-005 I i - Pr 4-C1 Br 143.0-145.0 3-006 I i - Pr 4-C1 ch3 145. 5-148. 5 3-007 I i-Pr 4-C1 Et 122.0-125.0 3-008 I i-Pr 4-C1 i-Pr 115. 0-117.0 3-009 I i-Pr 4-C1 cf3 112. 0-115.0 3-010 I i - Pr 4-Cl 0CH3 123. 0-126.0 3-011 I i-Pr 4-Cl sch3 116. 0-119. 5 3-012 I i-Pr 4-Cl N(CH3)2 ♦ 1 3-013 I i-Pr 4-C1 Ph-4-Cl 145. 0-147. 0 3-014 I i-Pr 4-Cl Ph+S02CH3 161.0-164.0 3-015 I i-Pr 4-Br ch3 169.0-177,0 3-016 I i-Pr 4-CH3 ch3 139. 5-140. 0 3-017 I i-Pr 4-CF3 ch3 185. 0-187. 5 3-018 I i-Pr 4-OCF3 Cl ♦ 1 3-019 I i-Pr 4-0CF3 ch3 115. 0-118.5 3-020 I i-Pr 4-OCF3 sch3 111.0-113.0 3-021 I i-Pr 4-OCF3 so2ch3 90· 0-93· 0 3-022 I i-Pr 4-OCF3 C(0)0Et ♦ 1
654 314918 200407073 3-023 I iHPr 4~0CF2Br ch3 191. 5-194.0 3-024 I i - Pr 4_0CH2CF3 ch3 156. 0-160.0 3-025 I i-Pr 4-0CF2CHF2 ch3 123. 0-125.5 3-026 I i-Pr 4-0CF2CHFCF3 ch3 *1 3-027 I 卜Pr 4-ocf2chfocf2cf2cf3 ch3 110. 0-112.0 3-028 I i-Pr 4 一0 (L-45g) ch3 174. 5—176. 0 3-029 I i -Pr 4-0(L-451) ch3 125.0-128.0 3-030 I i-Pr 4-SCH3 ch3 172. 0-174.0 3-031 I i-Pr 4-S02CH3 ch3 142. 0-144.0 3-032 I i-Pr 2, 4-Cl 2 ch3 210. 5-217.0 3-033 I i-Pr 3,4-Cl2 ch3 178. 0-179.5 3-034 夏 CH (CH3)CH2SCH3 4-Cl ch3 117.0-119.5 3-035 I CH (CH3)CH2SCH3 4-C1 Ph-4-Cl 137. 0-139.0 3-036 I CH (CH3)CH2SCH3 4-Br ch3 118· 0-120· 0 3-037 I CH (CH3)CH2SCH3 4-CF3 ch3 136.0-137· 5 3-038 I CH (CH3)CH2SCH3 4-OCF3 ch3 103. 0-107.0 3-039 I CH (CH3)CH2SCH3 4-0CF2Br ch3 104. 0-108.0 3-040 I CH (CH3)CH2SCH3 4-OCF2CHF2 ch3 110. 0-112. 5 3-041 I CH (CH3)CH2SCH3 4-0CF2CHFCF3 ch3 113. 0-116.0 3-042 I CH (CH3)CH2SCH3 4-0CF2CHF0CF2CF2CF3 ch3 本1 3-043 I CH (CH3)CH2SCH3 4~0 (L~45g) ch3 110. 0-114.0 3-044 I CH (CH3)CH2S(0) CH3 4-C1 ch3 127. 5-131.5 3-045 I CH (CH3)CH2S02CH3 4-C1 ch3 131. 0-134.0 3-046 I CH (CH3)CH2S02CH3 4-OCF3 ch3 122· 0-126· 5 3-047 I CH (CH3)CH2S02CH3 4~0CF2Br ch3 120. 0-123.0 3-048 I CH (CH3)CH2S02CH3 4-0CF2CHF2 ch3 125. 0-128.0 3-049 I c(ch3)2ch2sch3 4-Cl ch3 39· 5-42· 0 3-050 I C(CH3)2CH2S(0) ch3 4-Cl ch3 137. 0-14L5 3-051 I C(CH3)2CH2S02CH3 4-Cl ch3 129. 5-133. 0
655 314918 200407073 第11表
No. X R3 R4 A1 A2 A3 R5 in p. (t) 4-01 I i-Pr cf3 ch2 C(CN) 0 Ph 214. 0-215.0 4-02 I i - Pr cf3 ch2 N 0 Ph-4-Cl 138. 0-140.0 4-03 I i-Pr cf3 ch2 N 0 Ph-4-S02CH3 132. 0-134.0 4 - 04 I i - Pr cf3 ch2 N S Ph+Cl 121.0-123.0 4-05 I i-Pr cf3 0 N 0 Ph+F 99. 0-112.0 4-06 I 卜Pr cf3 0 N 0 Ph-4-Cl 114. 0-117.0 4-07 I i-Pr ch3 0 N ch2ch2 Ph+Cl 114. 0-121.0 第12表
No. X R3 R4 A1 A2 A3 R5 JSL P. (t：) 5-01 I i-Pr cf3 0 ch2 N Ph 222· 0-223· 0 5-02 I i-Pr Ph-4-Cl 0 ch2 N ch3 176.0-180· 0 656 314918 200407073 第13表
No· X R3 R4 R6e R5 m. p. (*C) 6-01 3-1 i-Pr H Ph-2-Cl ch3 204. 0-208. 0 6-02 3-1 i-Pr H Ph-4-Cl ch3 222. 5-224· 5 6-03 3-1 i - Pr H Ph-4-Cl cf3 172. 0-174. 0 6-〇4 3-1 i-Pr cf3 ch3 Ph-4-Cl 90. 0-92. 0 6-05 3-1 CH (CH3)CH2SCH3 H PH-Cl ch3 151. 0-154.5 6~06 3-1 c(ch3&gt;2ch2sch3 cf3 ch3 Ph-4-Cl 71.0-73.0 6-07 6-1 c(ch3&gt;2ch2sch3 cf3 ch3 Ph-4-Cl 125. 0-127.0 第1 4表
No. X R3 R4 A1-A2 A3 R5 DLP.CC) 7-01 I i - Pr ch3 o-ch2 0 H 207. 0-209. 0 7-02 I i-Pr cf3 (KH2 0 H 203. 0-204 5 7-03 I i - Pr cf3 (KH2 0 Ph-4-Cl 112. 0-114.0 7-04 I i - Pr cf3 ch2=n ch2 Pb 118.0-120.0 657 314918 200407073 7-05 I i-Pr Ph 0-CH2 0 H 222. 0-224.5 7-06 I i-Pr Ph-4-Cl o-ch2 0 H 233. 5-236· 0 7-07 I i-Pr Ph-4-Cl o-ch2 0 Et 223. 0-225. 5 7-08 I 卜Pr Ph-4-Cl 0-CH(CH3) 0 ch3 239· 0-243- 0 7-09 I 卜Pr Ph+Cl s-ch2 0 H 213· 5-217.0 7-10 I CH(CH3)CH2SCH3 cf3 (KH2 0 H 211. 0-213.0 7]1 I CH(CH3)CH2S02CH3 cf3 (KH2 0 H 134· 0-137· 0 第15表
R5 Να X R3 R4 R5 R6c m p. (t：) 8 - 01 I i-Pr cf3 Ph-4-Cl ch3 125.0-127.0 第16表
658 3M9]8 200407073
No. X1 R3 R4 R6j R6k m p. CC) 9-001 I i - Pr cf3 CN CN 218. 0-221.0 9-002 I i-Pr Ph-4-F Cl Cl 206. 0-210.0 9-003 I i - Pr PH-Cl H Br 186. 0-188. 0 9-004 I i-Pr Ph+Cl F F 201.5-210.0 9-005 I i-Pr Ph+Cl Cl Cl 216. 0-218.0 9-006 I i - Pr Ph-4-Cl Cl Br 204. 0-206.5 9-007 I i-Pr Ph-4-Cl Br Br 208. 0-212.0 9-008 I i-Pr Ph-4-Br Cl Cl 212.5-216.5 9-009 I i~Pr Ph+CH3 Cl Cl 170.5-173.0 9-010 I i-Pr Ph-4-0CF3 F F 205. 0-207. 0 9-011 I i - Pr Ph-4-0CF3 Cl Cl 206. 0-207. 5 9-012 I 卜Pr Ph-4-0CH2CF3 F F 109. 0-111.0 9-013 I 卜Pr Ph-4-0CF2CHF2 F F 204. 0-207. 0 9-014 I i - Pr Ph+SCH3 Cl Cl 168· 5-170· 5 9-015 I i-Pr Ph-4-S02CH3 Cl Cl 158.5-161.0 9-016 I CH(CH3)CH2SCH3 cf3 CN CN ♦ 1 9-017 I CH (CH3)CH2SCH3 Ph~4~F Cl Cl 231. 0-233.0 9-018 I CH (CH3)CH2SCH3 Ph+Cl H Br 179. 0-181.0 9-019 I CH (CH3)CH2SCH3 Ph+Cl F F 229· 0-232· 0 9-020 I CH (CH3)CH2SCH3 PH-Cl Cl Cl 223. 5-225. 0 9-021 I CH (CH3)CH2SCH3 Ph+Cl Cl Br 205. 0-207. 0 9-022 I ch(ch3)ch2sch3 Ph-4-Cl Br Br 202.5-206. 0 9-023 I CH (CH3)CH2SCH3 Ph+Br F F 223. 0-224 5 9-024 I CH (CH3)CH2SCH3 Ph-4_Br Cl Cl 220· 5-227.5 9-025 I CH (CH3)CH2SCH3 Ph-4-CH3 Cl Cl 158· 0-160. 5 9-026 I CH (CH3)CH2SCH3 Ph-4-CF3 F F 205. 0-208. 0 9-027 I CH(CH3)CH2SCH3 Ph-4-CF3 Cl Cl 175. 0-177.0 9-028 I CH (CH3)GH2SCH3 Ph-4-0CF3 F F 214.0-215-0 9-029 I CH(CH3)CH2SCH3 Ph-4-0CF3 Cl Cl *1 9-030 I CH (CH3)CH2SCH3 Ph-4-0CF2Br F F 185.0-186.0 9-031 I CH (CH3)CH2SCH3 Ph-4-0CH2CF3 F F 201.0-203.0 9-032 I CH (CH3)CH2SCH3 Ph-4-SCH3 Cl Cl 本1 9-033 I CH (CH3)CH2SCH3 Ph-4-S02CH3 Cl Cl ♦ 1 9-034 I CH(CH3)CH2S(0)CH3Ph-4 - 0Cf3 F F 184.0-185.0
659 314918 200407073 9-035 I ch(ch3)ch2so2ch3 cf3 CN CN *1 9-036 I CH(CH3)CH2S02CH3 Ph-4-Cl F F *1 9 - 037 I CH (CH3)CH2S02CH3 Ph+Cl Cl Cl 142. 0-144.5 9-038 I ch(ch3)ch2so2ch3 Ph-4-Cl Cl Br 149· 5-152. 0 9-039 I CH (CH3)CH2S02CH3 Ph+Br F F 227. 0-229. 0 9-040 I CH (CH3)CH2S02CH3 Ph~4~CF 3 F F *1 9-041 I CH (CH3)CH2S02CH3 Ph-4-0CF3 F F 210. 5-212.0 9-042 I CH (CH3)CH2S02CH3 Ph-4-0CF3 Cl Cl 190. 0-191.0 9-043 I CH (CH3)CH2S02CH3 Ph-—OCFzBr F F 169. 0-170. 0 9-044 I CH (CH3)CH2S02CH3 Ph+0CH2CF3 F F 132. 0-135. 0 9-045 I C(CH3)2CH2SCH3 Ph-4-F Cl Cl 211. 0-213.0 9-046 I C(CH3)2CH2SCH3 PH-Cl F F 216.5-218.5 9-047 I C(CH3)2CH2SCH3 Ph-4-Cl Cl Cl 213. 0-215.0 9-048 I c(ch3)2ch2sch3 Ph-4-Br F F 218. 0-219.0 9-049 I c(ch3)2ch2sch3 Ph~4~CF 3 F F 208. 0-211.0 9-050 I c(ch3)2ch2sch3 Ph-4-CF3 Cl Cl 136. 0-138.0 9-051 I c(ch3)2ch2sch3 Ph-4-0CF3 F F 212. 0-213.0 9-052 I c(ch3)2ch2sch3 Ph-4-0CF3 Cl Cl 102. 0-108. 0 9-053 I c(ch3)2ch2sch3 Ph-4-0CF2CHF2 F F 129· 0-135.0 9-054 I C(CH3)2CH2SCH3 Ph+OCH2CF3 F F 193· 0-195· 0 9-055 I C(CH3)2CH2S«))CH3 Ph-4~0CF3 F F 118. 0-120. 0 9-056 I c(ch3)2ch2so2ch3 Ph-4-Cl F F 197. 0-200. 5 9-057 I C(CH3) 2ch2so2ch3 Ph-4-Br F F 211. 0-213.0 9-058 I c(ch3)2ch2so2ch3 Ph-4-0CF3 F F 175. 0—176. 0 9-059 I c(ch3)2ch2so2ch3 Ph-4-OCF 3 Cl Cl 126. 0-128.0 9-060 I C(CH3)2CH2S02CH3 Ph-4-0CH2CF3 F F 118. 0-120.0 9-061 N02 i-Pr Ph+Cl F F 253· 5-256· 0 9-062 I i - Pr CH20CH3 Cl Cl 238.5-24 LO 9-063 I i-Pr Pb-4-F F F 218.0- 220.0 9-064 I CH (CH3)CH2SCH3 PH - F F F 226. 0-227. 0 9-065 I CH (CH3)CH2S02CH3 Ph-4-F F F 227. 0-228. 0
660 314918 200407073 第17表 .4 R«
No. ®m R3 R4 R6J R6k Re, R5 EP.CC) 10 - 01 3-1 i-Pr -ch2ch2ch2ch2 厂 H Cl Cl 228.5-230.0 10-02 3-1 i-Pr CN H H H Ph~4^Br 208. 5-210.0 10-03 3-1 i-Pr Ph-4-C1 Cl Cl H ch3 206. 0-209.0 10-04 3-1 CH(CH3)CH2SCH3 H Cl Cl H Ph *1 10-05 3-1 CH(CH3)CH2SCH3 CN H H H PlHHBr 106.0-109. 0 10 - 06 3-1 CH(CH3)CH2SCH3 Ph-4-Cl Cl Cl H ch3 143. 0-146.0 10-07 3-1 CH(CH3)CH2S02CH3 CN H H H Ph-4-Br 129. 0-132. 0 1(H)8 6-1 C(CH3) 2ch2sch3 pm-och2cf3 F F H H 114 (HRO 10-09 6-1 C(CH3) 2ch2sch3 Ph-4-OCF2CHF2 F F H H 231. 0-234 0
661 314918 200407073 第18表
No. Y1 R4 A1 A2 A3 R5 ep.CC) 11-01 ch3 cf3 ch2 cm 0 Ph-4-Cl *1 11-02 ch3 cf3 ch2 N 0 Ph-4-Cl ♦ 1 11-03 ch3 cf3 ch2 N 0 Ph-4-S02CH3 *1 11-04 ch3 cf3 ch2 N s Ph-4-Cl *1 11-05 ch3 H 0 N ch2 Ph-4-Cl *1 11-06 ch3 ch3 0 N ch2 ch3 ♦ 1 11-07 ch3 ch3 0 N ch2 Ph-4-F *2 11-08 ch3 Et 0 N ch2 Ph+Cl *1 11-09 ch3 n-Pr 0 N ch2 Ph-4-C1 本1 11-10 ch3 i - Pr 0 N ch2 Ph+Cl *2 11-11 ch3 c-Pr 0 N ch2 Ph-4-Cl *2 11-12 ch3 cf3 0 N ch2 Br *2 11-13 ch3 cf3 0 N ch2 ch3 *1 11-14 ch3 cf3 0 N ch2 t - Bu *1 11-15 ch3 cf3 0 N ch2 och3 *2 1卜16 ch3 cf3 0 N ch2 sch3 ♦2 11-17 ch3 cf3 0 N ch2 N(CH3)2 *2 11-18 ch3 cf3 0 N ch2 Ph ♦ 1 11-19 ch3 cf3 0 N ch2 Ph-4-F 108.5-110.0 11-20 ch3 cf3 0 N ch2 Ph-4-Cl 117. 5-119.0 11-21 ch3 cf3 0 N ch2 Ph-4-Br 128.5-131.5 11-22 ch3 cf3 0 N ch2 Ph-4-0CH3 ♦2 11-23 ch3 cf3 0 N ch2 Ph-4-0CHF2 ♦ 1 11-24 ch3 cf3 0 N ch2 Ph-4~0CF 3 58.5-61.5 11-25 ch3 cf3 0 N ch2 Ph-4-0CF2CHFCF3 #1 11-26 ch3 cf3 0 N ch2 Ph-4-0S02CH3 108. 0-110.0 11-27 ch3 cf3 0 N ch2 Ph-4-0 a-451) *1 11-28 ch3 cf3 0 N ch2 Ph+SCH3 82. 0-84. 0 11-29 ch3 cf3 0 N ch2 Ph+S (0) CH3 68.5-77. 0 662 314918 200407073 11~30 ch3 cf3 0 N ch2 Ph+S02CH3 164. 0-167.0 11-31 ch3 cf3 0 N ch2 Ph-4-N02 141.5-144.5 11-32 ch3 cf3 0 N ch2 Ph-4-N(CH3)2 *1 11 -33 ch3 cf3 0 N ch2 Ph-4-NHS02CH3 *1 11-34 ch3 cf3 0 N ch2 Ph-4-CN 117. 0-120.0 11-35 ch3 cf3 0 N ch2 L-lc 139. 0-141.0 11-36 ch3 cf3 0 N ch2 L-3c 97. 0-100.0 11-37 ch3 cf3 0 N ch2 L-3d 120. 0-122.0 1卜38 ch3 cf3 0 N ch2 L - 14a M 11-39 ch3 cf3 0 N ch2 L-24a ♦ 1 11-40 ch3 cf3 0 N ch2 L - 36a *1 11-41 ch3 cf3 0 N ch2 L，46d *1 11-42 ch3 cf3 0 N ch2 L - 46m *1 11-43 ch3 cf2cf2cf3 0 N ch2 ch3 ♦2 11-44 ch3 cf2cf2cf3 0 N ch2 Ph+Cl 本2 11-45 ch3 ch2och3 0 N ch2 PH-Cl ♦ 1 11-46 ch3 c (ch3) =noch3 0 N ch2 ch3 ♦ 1 11-47 ch3 C(CH3)=N0CH2Ph 0 N ch2 ch3 *1 11-48 ch3 Ph 0 N ch2 ch3 ♦ 1 11-49 ch3 Ph 0 N ch2 Ph-4-Cl 丰1 11-50 ch3 Ph-2-Cl 0 N ch2 ch3 *1 11-51 ch3 Ph-3-C1 0 N ch2 ch3 ♦ 1 11-52 ch3 Ph+Cl 0 N ch2 Cl *1 11-53 ch3 Ph-4-Cl 0 N ch2 Br *1 11-54 ch3 Ph-4-Cl 0 N ch2 ch3 ♦ 1 11-55 ch3 Ph+Cl 0 N ch2 och3 *2 11-56 ch3 Ph-4-Cl 0 N ch2 sch3 Μ 11-57 ch3 Ph-4-Cl 0 N ch2 N(CH3)2 ♦2 11-58 ch3 Ph-4-CF3 0 N ch2 ch3 本1 11-59 ch3 Ph-4-0CF3 0 N ch2 Cl ♦2 11-60 ch3 Ph-4-0CF3 0 N ch2 ch3 *1 11-61 ch3 Ph-4-0CF3 0 N ch2 sch3 *2 11-62 ch3 Ph-4-0CF3 0 N ch2 C(0)0Et ♦ 1 11-63 ch3 Ph-4-0CF2Br 0 N ch2 ch3 Μ 11-64 ch3 Ph-4-0CH2CF3 0 N ch2 ch3 Μ 11-65 ch3 Ph-4_0CF2CHF2 0 N ch2 ch3 *1 11~66 ch3 Ph-4-0CF2CHFCF3 0 N ch2 ch3 η 663 314918 200407073 11-67 ch3 Ph-4-0CF2CHF0CF: jCF2CF3 〇 N ch2 ch3 *2 11-68 ch3 Ph - 4 一0 (L-45g&gt; 0 N ch2 ch3 ♦ I 11-69 ch3 Ph-4-0 (L-451) 0 N nch2 ch3 *2 11-70 ch3 Ph - 3,4-Cl2 0 N ch2 ch3 ♦ 1 11-71 ch3 L-46d 0 N ch2 ch3 ♦ 1 11-72 ch3 cf3 0 N 0 Ph-4-F 78. 0-83. 0 11-73 ch3 cf3 0 N 0 Ph-4-Cl *1 11-74 ch3 cf3 nch3 N ch2 Ph-4-Cl *1 11-75 ch3 H _ - 2-C1) N ch2 ch3 ♦ 1 11-76 ch3 H _+Cl) N ch2 ch3 180. 0-184 5 1卜77 ch3 H N(Ph-4-Cl) N ch2 cf3 90· 0-93· 5 第19表
12-01 CH3 CF3 0 CH2 Ν Ph *1 12-02 CH3 Ph-4-Cl 0 CH2 N CH3 孝 1 664 314918 200407073 第2 0表 Υ1
R5 No. Y1 R4 A'-A2 A3 R5 up. (*C) 13-01 ch3 ch3 o-ch2 0 H *2 13-02 ch3 cf3 o-ch2 0 H *1 13-03 ch3 cf3 o-ch2 0 PH-C1 ♦ 1 13-04 ch3 cf3 CH=N ch2 Ph 13-05 ch3 Ph o-ch2 0 H 93. 0-97· 0 13-06 ch3 Ph+Cl (KH2 0 H *2 d20-31. 5805) 13-07 ch3 Ph-4-Cl (KH2 0 Et ♦2 nD20 3l. 5790) 13-08 ch3 PH-Cl 0 - ch(ch3) 0 ch3 85. 5-87. 0 13-09 ch3 Ph-4-Cl s - ch2 0 H ♦ 1 第2 1表
No. Y1 R4 R6c R5 m P. (O 14-01 ch3 cf3 ch3 Ph-4-Cl *1 第2 2表
665 314918 200407073
No. V R4 R6J R6k R5 EP.CC&gt; 15-01 ch3 H Cl Cl Ph *1 15-02 ch3 cf3 CN CN H *1 15-03 ch3 CN H H Ph~4~Br *1 15-04 ch3 Ph-4-F F F H *2 15-05 ch3 Ph-4-F Cl Cl H ♦2 15 -06 ch3 Ph-4-Cl F F H ♦2 (nD20*31. 5726) 15-07 ch3 Ph-4-Cl Cl Cl H *2 15-08 ch3 Ph-4-Cl Cl Cl ch3 *2 15-09 ch3 Ph-4-Cl Cl Br H *2 (nD2a31.5168) 15-10 ch3 Ph-4-Cl Br H H *2 15-11 ch3 Ph-4-Cl Br Br H *1 15-12 ch3 Ph+Br F F H *2 15-13 ch3 Ph-4-Br Cl Cl H *1 15-14 ch3 Ph+CH3 Cl Cl H *1 15-15 ch3 Ph-4-CF3 F F H ♦2 15 -16 ch3 Ph-4-CF3 Cl Cl H 135. 0-137. 0 15-17 ch3 Ph-4-0CF3 F F H *1 15-18 ch3 Ph-4-0CF3 Cl Cl H *1 15-19 ch3 Ph-4-0CF2Br F F H *1 15-20 ch3 Ph-4-0CH2CF3 F F H *2 15-21 ch3 Ph+0CF2CHF2 F F H *2 15-22 ch3 Ph-4-SCH3 Cl Cl H *1 15 - 23 ch3 Ph+S02CH3 Cl Cl H ♦ 1 第2 3表 ΟΥ1
R5 666 314918 200407073 •一~一· ----s ------—— No· ------ Y1 --*--- R4 A1 A2 A3 R5 —*一--- nip. (t：) 16-01 16-02 16 - 03 ---··— ch3 ch3 ch3 ----- cf3 cf3 cf3 丨 0 0 丨0 N N N ch2 ch2 ch2 Ph-4-F Ph-4-Cl Ph-4-S02CH3 ............... 221. 0^222.0 277. 5-279.5 274· 0-275. 0 第24表 —------
[ύ式驗例] 接下來，關於本發明化合物做為有害生物防除劑之有 用性，雖然在以下之試驗例中以具體說明，但本發明 此等限定。 將本發明化合物之1〇%乳劑（依化合物以水合劑 供試）用加入展著劑之水稀釋，調製成濃度為l〇〇ppm之藥 液。將撤揽之葉浸潰在該藥液中約1〇秒，風乾後放入帶蓋 玻璃器皿中，在每個帶蓋玻璃器皿中放入1〇隻模糊點斜$ 夜蛾（Spodotera litura)之2齡幼蟲，將蓋開孔並收容在^ 。(：之恆溫室中。調查6曰後之死蟲數，從以下之計算式算 出死蟲率。另外，該試驗以2區制進行。 # 314918 667 200407073 死蟲率（％) = (死蟲數/放蟲數）χ 1〇〇 結果’下述化合物顯示80%以上之死蟲率。 1-030^03^1 T〇32Vn!H ^006' ^012' ^015' ^016' ^〇22' ^024' ^025' ^026' h02L 1-028' 1- 048； 1^049： !&gt;0 ' ； &quot; ^°3&quot; ^03' ^037' ^039' ^04&quot; 2Ό10 2 Oil' 2 012' 1 h〇53' ^054 ^〇58' 2'°012&quot;005' 2&quot;0{)7' 2^008&gt; ^009' 2^025 2 m Γ ' Γ !' ^0112'01&quot; 2&quot;01' 2&quot;01' 2~〇18' 2~°19' 2~020^ 2-022.2-024 2^043 2 &quot; 2；02&quot; 2^°3' 2^°3&quot; ^036^ 2-040.2-04K 2-042. 2- 061,2-062,2-065^ ^ 2~〇5K 2'〇5i 2'°55^ 2~057* 2&quot;059' 2^°6^ 2- 085 2-086、2,2、2 _\~〇67、2一〇68、2—〇69、2—〇7〇、2—〇73、2一〇75、2一_、2—082、2一083上〇84 HOT： 2-：：： ；Ϊ η： ；：；；' ；：：；；' Π；：' Π；；' ^ H03,2,0, M〇, M0, ^122'2-3* M25： 2-126： 2-127： 2：129； 2：；；：； ^；；；；' ^；；；；· ；-；；9* ；-；32«· 2：；Γ9： 2：；^： 2：m* Η：!' Γ141' ^1&quot;'2-143' 2~144· 2-5： Ha 2 IB, MB, 3- 010,3-011 3-012 3 Πη\ Γ'2 ^6'2 1?9'3~〇01 3^004'3~005' 007. 9-008. 9-010 ο η；, 0 η ' 7'04' 7~1〇&gt; 8~〇Κ 9~002&gt; 9-°〇3. 9-004. 9-005. 9-006. 9- 〇24. 9-026. 9-027： 9-〇28； J2l Π30： Γο^： 9-022. 9-023. 9- 042. 9-043. 9-045, 9-〇46&gt; 9-047. 9-048. 9-049. 9-〇5〇' 9- ' _ ' Γ ' 9~〇39* Γ 057, 9-058, «9, 9-060,10-02,10^05 Κ 9 052、9一〇53 j〇5i 9-055、9-056、9- 忒驗例2對於小菜蛾之殺蟲試驗 〇、將本發明化合物之10%乳劑（依化合物以洲水合劑 i&quot;式)用加入展著劑之水稀釋’調製成濃度為l〇〇ppm之藥 =撤復之葉浸潰在該藥液中約1。秒，風乾後放入帶蓋 玻…中’在每個帶蓋玻璃器皿中放 (PI_a Xyl〇stella)之2齡幼蟲，將蓋開孔並 之恆溫室中。調查6曰後之死蟲數，從與試驗广％ 计异式算出死蟲率。另夕卜’該試驗以2區制進行:冋樣之 3149]8 668 200407073 結果，下述化合物顯示80°/。以上之死蟲率。 本發明化合物：No.卜001、卜002、卜004、卜005、卜006」-007、卜008、卜009」-011、卜012、卜013、 卜014、卜015、卜016、1 一017、1-018、卜019、1-020、卜02U-022、卜024、卜025,卜026、卜027、卜028, 卜029M-030、卜031、卜032, 1 -033、卜034、卜035、卜036、卜037、1 一038、卜039、卜040、1 一041、卜042、 卜043、卜044、卜045，卜046、卜047、卜048、卜049、卜050、卜051、卜052、卜053、卜054、卜055、卜056, 卜057、卜058,2-001、2-002、2-005、2—006、2-007、2-008、2-009、2-010、2-011、2-012、2-013、2-014、 2-015、2-016、2-017、2—018、2-019,2-020、2-02K 2-022,2-023、2-024 2-025, 2-026、2-027、2-028、 2-029、2-030、2-032、2-033、2-034、2-036、2-037、2-038、2-039、2-040、2-041、2-042、2-043、2-044、 2-045、2-046、2-047、2-048、2-04H050、2-05h 2-052、2-053、2-054、2—055、2-057、2-058、2-059、 2-060、2-06K 2-062、2—063、2-064、2-065、2-066、2-067、2-068、2-069、2-070、2_071、2-072、2-073、 2-074、2-075、2-076、2-077、2-078、2-079、2-080、2-082、2-083、2-084、2-085、2-086、2-087、2-088、 2—089、2-090、2-091、2-092、2-093、2-094、2-095、2-096、2-097、2-098、2-100、2-101、2-103、2-104、 2_105、2-106、2-107, 2-108、2-109、2-110、2- 11U-112、2-113、2- 1R 2-115、2-116、2-117、2—119、 2-120、2-121、2-122、2-123、2-124 2-125、2-126、2-127、2-128、2-129、2-130、2-131、2-132、2-133、 2-134、2-135、2-136、2-137、2-138、2-139、2-140、2- 14L 2-142, 2-143、2-144、2-145、2-146、2-147, 2-14&amp; 2—149, 2-150、2-151、2-152、2-153、2-154、2-156、2-157、2- 16U-162、2-163、2-164、2-167、 2- 168、2-169、2-170、2-171、2-172、2-173、2-174、2-175、2-176、2-177、2-178、2—179、3-00U-002、 3- 003、3-004、3-005、3-006、3-007、3—008、3-009、3-010、3-011、3-012、3-013、3-014、3-015、3-016、 3-017、3-018、3_019、3-020、3-021· 3-022、3-023、3-024、3-025、3-026、3-027、3-028、3-029» 3-030、 3-031、3-032、3_033、3-034、3—035、3-036、3-037、3-038、3-039、3-040、3~~041、3—042、3-043、3-044、 3-045、3-046、3-047、3-048、3-049、3-050、3-051、4-01、4-02、4-03、4-04 4-05M-06, 4-07、5-01、5-02、6-01、6-02、6-03、6-04、6-05、6-06、7-01、7-02、7-03、7-04、7-05、7-06、7-07、7-08、7-09、7-10、 7-11、8-01、9一001、9—002、9-003、9一0(R 9-005、9一006、9-007, 9-008、9-009、9一010、9一011、9一013、9一 014、9-015、9-016、9一017、9一018、9-019、9-020、9-021、9一022、9一023、9一024、9-025、9-026、9-027, 9-028、9-029、9-032、9-033、9一034、9-〇35、9-036、9-037、9-038、9_039、9-041, 9-045、9-046、9-047» 9-048、9-049、9-050, 9-051、9-053、9-055、9-056、9-057、9-058、9-06M0-01、10-02、10-03、10-04、 10-05、10 - 06、10 - 09 [產業上之利用可能性] 依照本發明之N-取代苯甲醯苯胺化合物顯示優異的 有害生物防止及去除活性，尤其是殺蟲及殺蟎活性，而且 對於哺乳動物、魚類及益蟲等非標的生物大體無不良影 響，為極有用之化合物。 669
314918

Claims (1)

  1. ° 1申請專利範圍： •〜種通式+ _ · I、之取代N-苯（甲）醯苯胺化合物或其
    A [式中： m 表示包έ至少1個從氧原子、硫原子及氮原子中 =出之原子且環内存在至少1個雙鍵之5員或6員非芳 矢錶環，包含2個從氧原子、硫原子及氮原子中選出 之原子之5員或6員飽和雜環或3員至6員之環烷基 環； W及W各自獨立，分別表示氧原子或硫原子；籲 X表不鹵素原子、氰基、硝基、疊氮基、-SCN、-SF5、C】-6烷基、被R7任意取代之（C1_6)烷基、c3 8環烷 基、被R7任意取代之C：3·8環烷基、〔2·6烯基、被R7任 意取代之（C2-6)烯基、Cm環烯基、c3 8鹵代環烯基、6 块基、被R任思取代之（^2_6块基、·〇η、-〇R8、_〇s (〇)2R8 …SH、-S(0)rR8、-CHO、-C(0)R9、-C(0)〇R9、 一C(〇)Sr9、-C(0)nhr】〇、_c(〇)n(r】g)r9、c(s)〇r9、_ C(S)SR9、-C(S)NHR】0、-C(S)N(R，R9、-CH二NOR&quot;、- 314918 670 200407073 C(R9)=NORn、-S(0)20R9、-S(0)2NHR1()、-S(0)2N(R10) R9、-Si(R13)(RI4)R12、可被（Zi)pi 取代之苯基、L 或 M， 111表不2、3或4日守，各個X可彼此相同或相異，再者， 在2個X鄰接之情況，可藉由鄰接之2個X形成_ CH2CH2CH2-、-CH2CH20-、-CH2OCH2-、-〇CH20-、_ CH2CH2S-、-CH2SCH2-、-CH2CH2N(R15)-、-CH2N(R15) ch2-、-ch2ch2ch2ch2-、-ch2ch2ch20-、-ch2ch2 och2-、-ch2och2o-、-〇ch2ch2〇-、-〇ch2ch2s-、- # CH2CH=CH_、-〇CH=CH_、-SCH=CH_、_N(R15)C!H=CH_、 _OCH=N_、_SCH=N_、-N(R〗5)CH=N_、-N(R15)N=CH_、 -CH=CHCH = CH_、_OCH2CH = CH_、_N=CHCH=CH-、_ N=CHCH=N-或-N=CHN=CH-，且與各個所鍵結之碳原 子共同形成5員環或6員環，此時，形成環之各個碳原 子所鍵結之氫原子可被Z1任意取代，再者，在同時被2 個以上之Z1取代之情況，各個Z1可彼此相同或相異； 又’ G表示包含至少1個從氧原子、硫原子及氮原肇 子中選出之原子且環内存在至少1個雙鍵之5員或6員 非务香族雜環時，X可另表示-N(R17)r16、__n = ch〇r12 或-N=C(R9)〇r12 ; Y表示鹵素原子、氰基、硝基、疊氮基、_SCN、-SF5、c〗_6烷基、被R7任意取代之（Cl 6)烷基、c3 8環烷 基、被R7任意取代之（(：3.8)環烷基、-OH、_〇r8、4S(c〇2 R ' -SH、-S(0)rR8、-NH2、C】.6 烷胺基、二（c】6 烷基） 胺基、Si(R]3)(R〗4)R〗2、可被（Z】）pi取代之苯基、L或μ， 67] 314918 200407073 η表示2、3或4時，各個γ可彼此相同或相異； 再者’在2個Υ鄰接之情況，藉由鄰接之2個γ形成 -CH2CH2CH2_、_CH2CH20_、_CH20CH2-、-0CH20-、- ch2ch2s-、-CH2SCH2-、-SCH2S·、-ch2ch2ch2ch2-、 -ch2ch2ch2o-、-ch2ch2och2-、-ch2och2〇-、-〇CH2 CH20-、-〇CH2CH2S-、-SCH2CH2S-、-〇CH=N-或-SCH= N-，2個Y之各個與其所鍵結之碳原子可形成5員環或 6員環，此時，形成環之各個碳原子所鍵結之氫原子可 _ 被Z1任意取代，再者，在同時被2個以上之zl取代之 情況，各個Z1可彼此相同或相異； R1，R2及R3各自獨立，分別表示氫原子、氰基、 CVu烧基、被R〗8任意取代之（Cll2)烷基、（：312環烷基、 被R18任意取代之（C3l2)環烷基、C3l2烯基、被ru任 意取代之d-i2)稀基、C3-12環稀基、C3_i2鹵代環稀基、 C3-12炔基、被RH任意取代之炔基、_〇h、ci 8 烷氧基、Cs_8烯氧基、c3_8鹵代烯氧基、可被（Z】）pl取代 _ 之苯氧基、可被（Z〗）pl取代之苯基（(^_4)烷氧基、烷 硫基、Cle6鹵代烷硫基、可被（z1)^取代之苯硫基、_ S(〇)2R9、-SN(R20)R】9、-S(O)2N(R10)R9、-N(R22)R21、- C(0)R9、-C(〇)〇R9 …C(0)SR9、-C(0)N(R1G)R9、-C(S) OR9、-C(S)SR9、-C(S)N(R1G)R9、可被（z])pl 取代之苯基、 L或M’或者表示藉由r2與r。一起形成c2_6伸烧基鏈， 並與鍵結之氮原子共同形成之3至7員環，此時該伸烷 基鏈可包含1個氧原子、硫原子或氮原子，且可被鹵素 672 3149)8 200407073 原子、Cu烧基、C!_6鹵代烧基、Cu：)：完氧基、c1-6烧幾 基或c1-6烷氧羰基任意取代； R4表示氫原子、鹵素原子、氰基、Cp6烧基、Cu 鹵代烷基、被R23任意取代之（Chd烷基、被R23任意取 代之（C^)鹵代烷基、C3_8環烷基、C3-8鹵代環烷基、被 R23任意取代之（C3.8)環烷基、被R23任意取代之（c3_8) i代環烷基、c3_6烯基、c3_6鹵代烯基、C3_6炔基、c3. 6 鹵代炔基、-OR8、-S(0)rR8、-N(R10)R9、-CHO、-C(0)R9、 # -C(0)〇R9、-C(0)SR9、-C(0)NHR1G、-C(0)N(R1Q)R9、-C(S)〇R9、_C(S)SR9、-C(S)NHR10、_C(S)N(R10)R9、-CH= nor11、_C(R9)=N〇RH、-Si(R13)(R14)R12、_p(〇)(〇R24)2、 可被（Z2)pl取代之苯基、1-萘基、2-萘基、L或M ; R5 0)G表示包含至少1個從氧原子、硫原子及氮原子中選 出之原子且環内存在至少1個雙鍵之5員或6員非芳香 族雜環，或者包含2個從氧原子、硫原子及氮原子中選 _ 出之原子之5員或6員飽和雜環時，R5表示氫原子、鹵 素原子、氰基、CV6烷基、Cw鹵代烷基、被R23任意 取代之（C^)烷基、被R23任意取代之（(^_6)鹵代烷基、 C：3-8環烧基、C3.8鹵代環烧基、被R23任意取代之（c3_8) 環烷基、被R23任意取代之（c3_8)鹵代環烷基、c3.6烯基、 C3_6鹵代烯基、C3-6炔基、C3.6鹵代炔基、-〇R8、-S(0)rR8、 -N(Rl〇)R9、-CH〇、_C(〇)R9、-C(〇)〇R9、-C(〇)SR9、- C(0)NHR10、-C(〇)N(R10)R9、-C(S)〇R9、-C(S)SR9、- 673 314918 200407073 C(S)NHR10、-C(S)N(Ri〇)R9、-CH=n〇r1i、_c(R9) = NOR1】、可被（Z2)pl取代之苯基、丨_萘基、2_萘基、L或 Μ ； (b) G表示3員至6員之環烷基環且化4表示氫原子、鹵 素原子、:)：完基或CK6鹵代烷基時，R5表示氰基、被 R23任意取代之（C】·6)烷基、被r23任意取代之（Ci 6)鹵代 烧基、CM環烧基、C3_8鹵代環烷基、被R23任意取代 之（Cs_8)環烷基、被R23任意取代之（c3 8)鹵代環烷基、 C3_6稀基、C3_6鹵代烯基、c3 6炔基、c3_6鹵代炔基、- OR8、_S(0)rR8、-N(R10)R9、-CH〇、-C(〇)R9、_c(〇)〇R9、 -C(0)SR9 ^ -C(0)NHR1〇 . .C(O)N(R10)R9 &gt; -C(S)OR9 &gt; -C(S)SR9 &gt; -C(S)NHR10 x -C(S)N(R10)R9 ^ -CH=NORn &gt; -C(R9)=NORu、-Si(R13)(R，Ri2、可被(zqpl 取代之苯 基、1-萘基、2 -萘基、L或Μ; (c) G表示3員至6員之環烷基環，且R4表示氰基、被 R23任意取代之（C^)烷基、被R23任意取代之（C^)鹵代 烷基、C3_8環烷基、C^8鹵代環烷基、被R23任意取代 之（C3_8)環烷基、被R23任意取代之（C3_8)鹵代環烷基、 C3.6稀基、C3_6鹵代細基、（33_6炔基、C3_6鹵代快基、-OR8、-S(0)rR8、-N(R10)R9、-CHO、-C(0)R9、-C(0)0R9、 -c(o)sr9、-c(o)nhr1g、-c(o)n(r1C))r9、-c(s)or9、- C(S)SR9、-C(S)NHR]Q、-C(S)N(R1G)R9、-CH=NORn、-C(R9)=NORu、-Si(R13)(R14)R12、-P(0)(0R24)2、可被（Z2)pl 取代之苯基、卜萘基' 2-萘基、L或M時，R5表示氫原 674 314918 200407073 子、鹵素原子、氰基、（C!-6)烷基、Cw鹵代烷基、被 R23任意取代之（C!-6)烷基、被R23任意取代之（Cl-6)鹵代 烷基、C3_8環烷基、C3-8鹵代環烷基、被R23任意取代 之（c3·8)環烧基、被R23任意取代之（c3·8)鹵代環烧基、 c3_6烯基、C3-6鹵代烯基、C3-6炔基、c3_6鹵代炔基、-OR8、-S(0)rR8、-N(R1Q)R9、-CHO、-C(0)R9、-C(0)0R9、 -C(O)SR9、-C(〇)NHR10、-C(O)N(R10)R9、-C(S)OR9、-C(S)SR9、-C(S)NHR1()、-C(S)N(R10)R9、-CH=NORn、-籲 C(R9)=NORn、-Si(R13)(R14)R12、可被（Z2)pl 取代之苯 基、1-萘基、2-萘基、L或Μ ; R6表示氫原子、素原子、氰基、（CV6)烧基、（Cu) 鹵代烷基、被R23任意取代之（Chd烷基、被R23任意取 代之（c1-6)鹵代烧基、03_8環烧基、C3_8鹵代環烧基、被 R23任意取代之（Cs·8)環烷基、被R23任意取代之（c3-8) 鹵代環烧基、c1-6烧氧基、c1-6鹵代烧氧基、c^6烧硫 基、CV6 i 代烧硫基、-S(0)2R9、-C(〇)R9、-C(0)0R9、 Φ -C(0)SR9、-C(S)OR9、-C(S)SR9、-C(〇)N(R1Q)R9、-C(S) N(R1())R9、-P(0)(0R24)2、 -P(S)(〇R24)2、可被（Z2)pl 取代 之苯基、1-奈基、2-萘基、L或Μ，1表示2以上之整 數，各個R6可彼此相同或相異；
    再者，在R6 及R6形成q 至7員環；！fcl 子，且可被C】_6烷基任意取代； 314918 675 200407073 L表示式L-1至L-58之任一者所表示之芳香族雜 環：
    L·! L-2 L-3 L-4 L-5
    L-20
    L-21 L-22 L-23 L-24 L-25
    L-26 L-27 L-28 L-29 L-30 676 314918 200407073
    L-31 L-32
    N ΓΓ L-35 (zV
    L-36 R15 R15 N-Ν' 、N-N L-37 L-38
    L-46 (z\3 (z\3；0)&lt;xa J? (Z%3 L-47 L-48 N.
    N、 L-49(zV F(Z^J[ ^&lt;z V
    (Z1^ (Z*)p4,Jfj L-54 L-50 L-51 L-53
    M表示式M-l至M-28之任一者所表示之飽和雜 % · 677 314918 200407073
    M-l
    Μ·2 M-3 (R25)q2 (〇)r (R2%3 (R25)q3 M-4 M-5 M-6 M-7 M-8
    M-24 M-25 Μ·26 M-27 M-28 z1表示鹵素原子、氰基、硝基、cv6烷基、cv6鹵 678 314918 200407073 代烧基、Cs_6環烷基、c3_6鹵代環烷基、c2_6烯基、c2-6鹵代烯基、c2_6炔基、c2_6鹵代炔基、烷氧基、 函代烧氧基、Cw烷硫基、Cw鹵代烷硫基、（γ6烷亞 石黃酿基、cv0鹵代烷亞磺醯基、Cl_6烷磺醯基、cv6鹵 代烧績酸基、Cu烷胺基、二（C】_6烷基）胺基、Ci 6烷氧 罗炭基、鹵代烷氧羰基或可被鹵素原子任意取代之苯 基’ p 1 ’ p2，p3或p4表示2以上之整數時，各個z1 可彼此相同或相異； _ Z2表示鹵素原子、氰基、硝基、胺基、疊氮基、· SCN、-SF5、C&quot;烷基、被R7任意取代之（Ci 6)烷基、 C^8環烷基、被R7任意取代之（c3_8)環烷基、c2.6烯基、 被R7任意取代之（C2_6)烯基、C3-8環烯基、c3_8鹵代環 烯基、C2_6炔基、被R7任意取代之（C2-6)炔基、-〇1^、- 〇R8、-0S(0)2R8、-SH、-S(0)rR8、-N(R10)R9、- n(R10) CHO、-N(R10)C(O)R9、-N(R10)C(O)OR9、-N(R]0)C(O) SR9、-N(R1G)C(S)OR9、-N(R1G)C(S)SR9、-N(R1G)s(〇)2R9、 # -CHO、-C(0)R9、-C(0)0R9、-C(0)NHR1G、-C(0)N(R10) R9、-C(S)NHR10、-C(S)N(R10)R9、-S(0)20R9、_S(0)2 NHR10、_S(O)2N(R10)R9、_Si(R]3)(R14)R]2、可被（zi)pi 取代之苯基、L或M，pi表示2以上之整數時，各個 Z2可彼此相同或相異； 再者，在2個Z2鄰接之情況，可藉由鄰接之2個Z2形 成-CH2CH2CH2-、-CH2CH20-、-CH2OCH2·、-〇Ch2〇_、 -CH2CH2S-、-CH2SCH2-、_CH2CH2CH2CH2-、-CH2CH2 679 314918 CH2〇_、_CH2CH2OCH2-、_CH2〇CH20_、_〇CH2CH20-或 -0CH2CH2S-，並與2個z2之各個鍵結之碳原子共同形 成5員環或6員環，此時，形成環之各個礙原子所鍵結 之氫原子可被鹵素原子或c烷基任意取代； R7表示鹵素原子、氰基、C3_8環烷基、C3_8鹵代環 烷基、-OH、-OR8、-SH、-S(0)rR8、-N(R1G)R9、-N(R10) CHO、-N(R1G)C(0)R9、-N(R1G)C(0)0R9、-N(R1())C(0) SR9、-N(R1G)C(S)OR9、-N(R10)C(S)SR9、-N(R1G)S(0)2R9、 -C(0)OR9、-C(0)N(R1G)R9、-Si(R13)(R14)R12、可被（Z!)pl 取代之苯基、L或M; R8表示Cu烷基、被r27任意取代之（Ci j烷基、 C3_8環烷基、被R27任意取代之（C3 8)環烷基、Gy烯基、 被R27任意取代之（C2·6)烯基、Ch環烯基、Gw _代環 烯基、C3·6炔基、被R27任意取代之炔基、可被（zl)pi 取代之笨基、L或Μ; Ρ R9表示Cw烷基、Ci 6 _代烷基、C3 6環烷基（〔I 烷基、c,_6烷氧基（Ci-4)烷基、Ci_6烷硫基（υ烷基、 氰基（Cw)烷基、可被（ζ,)ρΐ取代之笨基（υ烷基、l_ D烧基' m-(Ci.4)垸基、C3 8環烧基、C3 8_代環烷 基、C3.6烯基、c3_6鹵代烯基、c3 6炔基或可被 代之苯基； P1 R表不虱原子或C】-6烷基，或者表示藉由R9盥 -起形成c2.6伸烷基鏈，並與鍵結 ;、 之…員環，此時之伸靡可含有i個氧原= 3149)8 680 200407073 原子或氮原子，且可被鹵素原子、Cw烷基、cN6烷氧 基、甲醯基、烷基羰基或Cp6烷氧基羰基任意取代； R11表示氫原子、CV6烷基、Ci_6鹵代烷基、可被（Z1)〆 取代之本基（Ci_4)烧基、C3_6稀基、C3-6 _代細基、C3-6 炔基或c3_6鹵代炔基，或者表示藉由R9與R11 一起形成 C2_4伸烷基鏈，並與鍵結之原子共同形成之5至7員 環，此時之伸烷基鏈可含有1個氧原子、硫原子或氮原 子，且可被鹵素原子或烷基任意取代； 鲁 R12表示CV6烷基、Cw鹵代烷基、c3_6烯基或可被 (z])pl取代之苯基； R 3及R14各自獨立’表示Cu烧基或CV6鹵代烧 基； R15表示氫原子、c1-6烷基、Ci 6鹵代烷基、Cl.6烷 氧基魏基（Ch4)烷基、C1-6鹵代烷氧基羰基（CbJ烷基、 可被（Z1)^取代之苯基（cv4)烷基、c3 6烯基、c3 6鹵代 稀基、（：3_6炔基或c3_6鹵代炔基、Ci 6烷氧基、Cl_6烷 φ 氧基m基、c]_6鹵代烷氧基羰基或可取代之苯 基； 反16表示氫原子、Cw烷基、CY6鹵代烷基、〇3_6環 烷基（c〗_4)烷基、C卜4烷氧基（C14)烷基、（：丨_4烷硫基（c].4) 燒基、可被（z1、取代之苯硫基（Ci 4)烷基、氰基（Ci 6) 烷基、C】·6烷氧基羰基（Cl_4)烷基、66烷胺羰基（c】_4) 、元基 一（Ci·6少元基）月女基幾基（c]-4)烧基、可被（ζ】）ρ1取 代之笨基（(：】·4)烷基、L^Cw)烷基、M-(Ci4)烷基、c3 6 681 314918 200407073 %烧基、C3_6焊基、C3-6鹵代稀基、C3_6炔基、C3_6鹵代 炔基、-OH、Cw烷羰氧基、Cw烷硫基、CV6鹵代烷硫 基、可被（Z )pl取代之苯硫基、Cj.6烧續龜基、Cu鹵代 烧磺醯基、可被（z1：^取代之苯磺醯基、_SN(R2G)Rl9、 Cu烷胺磺醯基、二（(^·6烷基）胺磺醯基、_CHO、-C(O) R9、-C(0)0R9、_c(0)SR9、-C(0)NHR10、-C(O)N(R10)R9、 -C(S)OR9、_C(S)SR9、-C(S)NHR10、-C(S)N(R10)R9、- C(0)C(0)R9、-C(0)C(0)0R9、-P(〇)(〇r24)2 或_?(8) # (〇R24)2 ； R17表示氫原子、Cw烷基、Cw鹵代烷基、C3_8環 烷基（C】·6)烷基、c3_8環烷基、c3_6烯基、c3_6鹵代烯基、 c3.6炔基、C3_6函代炔基、-CHO、Cl.6烷羰基、Cb6 _ 代烧Ik基或Cw烧氧戴基；或者表示藉由ri6與R17 一 起形成C2·6伸烷基鏈，並與鍵結之原子共同形成之3至 7員環’此時之伸烷基鏈可含有1個氧原子、硫原子或 氮原子’且可被鹵素原子、CY6烷基或cv6鹵代烷基任修 意取代；再者可表示藉由R”與R2 一起形成Ci 2伸烷基 鏈，並與鍵結之原子共同形成之與苯環稠合之6或7員 雜環，此時之伸烷基鏈可被氧原子或c16烷基任意取 代； R]8表示鹵素原子、氰基、硝基、C3 8環烷基、C ό - 8 鹵代環烧基、-〇以28、_!\[(1129)1^28、-；5^1、_8(〇)1_1130、_ CHO、-C(0)RJ1、-C(〇)〇H、_c(〇)〇 R3i、-C(〇)s r31、 -C(〇)NHR’2、-C(〇)N(R32)R3】、-C(0)C(0)0R3】、-C(R34) = 314918 682 200407073 NOH、_C(R34)=NOR33、-Si(R13)(R14)R12、-P(0)(〇R24)、 -P(S)(OR24)2、-p(苯基）2、·ρ(〇)(苯基）2、可被（zl)p】取 代之苯基、L或Μ ; R19表示c&quot;2烷基、Ci i2鹵代烷基、C〗_12烷氧基 (CH2)烷基、氰基（Cl_i2)烷基、〇112烷氧羰基（CW2)烷 基、可被（zi)pl取代之苯基（Ci 4)烷基、c3 】2烯基、 鹵代烯基、Cm炔基、Cm鹵代炔基、〇112烷羰基、 C^2烧氧羰基或可被（ζι)ρΐ取代之苯基； · R表不CV12烧基、〇v12i代烷基、（^·Ι2烷氧基 (cv12)烧基、氰基（Ci i2)烷基、〇112烷氧羰基（Cl &quot;)烷 基、可被（Zi)pl取代之苯基（Ci 4)烷基、c3_l2烯基、C312 鹵代稀基、Cm炔基、Cn2鹵代快基、或可被（^。…取 代之苯基，或者表示藉由R!9與R2〇 一起形成Cw伸烷 基鍵’並與鍵結之氮原子共同形成之5至8員環，此時 之伸烧基鏈可含有1個氧原子或硫原子，且可被C 1-4 烧基或C]_4烷氧基任意取代； 鲁 R21表示氫原子、c】_6烷基、CY6鹵代烷基、可被（z〗）pi 取代之苯基（c1-4)烷基、c3_6烯基、c3_6鹵代烯基、匕 炔基、-CHO、Cy烷羰基、C】_6鹵代烷羰基、〇1-6烷氧 魏基、C】.6鹵代烷氧羰基、可被（zl)pi取代之苯基（Ci 4) 烧氧It基、可被（zypi取代之苯氧羰基、可被取代 之笨羰基或可被（zi)m取代之苯基； R22表示氫原子、Cl_6烷基、-CHO、（V6烷羰基、 c】·6鹵代烷羰基或Cl_6烷氧羰基； 683 314918 R23表示氰基、C3_8環烷基、C3_8鹵代環烷基、-oh、 -OR8、-SH、，S(0)rR8、-N(R1G)R9、-N(R1G)CHO、 -N(R1G)C(0)R9、-N(R1G)C(0)0R9、- n(R1g)C(0)SR9、 .N(R10)C(S)OR9 &gt; -N(R10)C(S)SR9 ^ -N(R10)S(O)2R^ &gt; . C(〇)〇R9、-C(0)N(R1G)R9、-Si(R13)(R14)Ri2、可被（zl)pi 取代之苯基、L或M ; R24表示C1-6烧基或Cu鹵代烧基； R25表示鹵素原子、氰基、C1-6烷基、鹵代烷基、 羥基（CV6)烷基、Cm烷氧基（c^)烷基、cv4烷氧羰基 (C!·4)烷基、C]·6烷氧基、CV6烷氧羰基或可被（ζι)ρΐ&gt; 代之苯基，ql、q2、q3或q4表示2以上之整數時，各 個R25可彼此相同或可彼此相異； R 6表示氫原子、C〗_6烧基、ci-6鹵代烧基、_CH0、 C1-0烧.基、烧幾基、可被（^ι)ρΐ取代之苯基 (C】—4)烷羰基、Cw烷氧羰基、ci6鹵代烷氧羰基、可被 (ζ1)。]取代之苯基（Cl 4)烷氧羰基、Ci_6烷胺羰基、二（c]_6 烷基）胺羰基、烷胺硫羰基、二（Ci 6烷基）胺硫羰基、 可被（z】）pl取代之笨羰基、Ci·6烷磺醯基、Ci 6函代烷磺 基、可被（Z】）pl取代之苯磺醯基、_p(〇)(〇R24)2或一 P(S)(〇R24)2 ； R27表示鹵素原子、氰基、cs_8環烷基、c3 8鹵代環 烷基、c〗·6烷氧基、c^6鹵代烷氧基、Ci 6烷硫基、 6鹵代烷硫基、C〗_6烷磺醯基、Ci 6i代烷磺醯基、 烷胺基、二（cv6烷基）胺基、_CH0、c&quot;烷羰基、c · 314918 684 200407073 鹵代烧幾基、Ci_6烧氧魏基、（Ζν6鹵代烧氧獄基、-CH= NOR11、-C(R9)=NORu、可被（Z1)^ 取代之苯基、L 或 Μ; R28表示氫原子、C1&lt;&gt;8烧基、可被R35任意取代之（C1-8) 烷基、C3_8環烷基、可被R35任意取代之（C3_8)環烷基、 C3_8烯基、可被R35任意取代之（C3.8)烯基、C3_8炔基、 可被 R35 任意取代之（C3.8)炔基、-CHO、-C(0)R31、-C(O) OR31、-C(0)SR31、-C(0)NHR32、-C(0)N(R32)R31、-C(O) C(0)R31、-C(0)C(0)0R31、-C(S)R31、-C(S)OR31、-C(S) _ SR31、_C(S)NHR32、_C(S)N(R32)R31、_S(0)2R31、-S(0)2 N(R32)R31、-Si(R13)(R14)R12、_P(〇)(〇R24)2、-P(S) (OR24)2、可被(z1：^取代之苯基、L或M ; R29表示氫原子、C1-6烷基、CY6鹵代烷基、C3_6環 烷基或Cw烷氧基，或者表示藉由R28與R29 一起形成 C2·5伸烷基鏈，並與鍵結之氮原子共同形成之3至6員 環，此時之伸烷基鏈可含有1個氧原子或硫原子，且可 被鹵素原子、CV6烷基、ίγ6烷氧基或可被（ζι)ρΐ取代之參 苯基取代； R30表示Ο：&quot;烷基、可被R35任意取代之（Ci 8)烷基、 Cs_8環烧基、可被R35任意取代之環烷基、c3 8烯 基、可被R任思取代之（C3 ·8)稀基、c 3 _ 8炔基、可被 R35任意取代之（C3_8)炔基、-SH、Cl_6烷硫基、Cb6鹵代 烧硫基、可被（ΖΟρ]取代之苯硫基、_ch〇、-C(0)R31、 -C(0)0R、-C(〇)SR」、-C(0)NHR32、-C(0)N(R32)R31、 -C(0)C(0)R。]、-C(0)C(0)0R。】、—c(S)R31、-C(S)OR3】、 314918 685 200407073 -C(S)SR31、-C(S)NHR32、C(S)N(R32)R31、-p(o)(or24)2、 -卩（8)(〇1124)2、可被(^1^1取代之苯基、1^18、1^21、1^25、 L-30 至 L-35 、 L-45 、 L-48 、 L-49 或 M ; R31表示Cw烧基、Ci 6鹵代烷基、c3 8環烷基（Ci 4) 烷基、C〗_6烷氧基（Ci4)烷基、Ci6鹵代烷氧基（Ci4)烷 基、烷硫基（Ci 4)烷基、ci 6鹵代烷硫基（Ci 4)烷基、 C〗·6烷％醯基（Cw)烷基、ci-6鹵代烷磺醯基（(^_4)烷基、 氰基（C】·6)烷基、ci-6烷羰基（Ci4)烷基、Cl_6鹵代烷羰馨 基（Cy)烷基、Cb6烷氧羰基（Ci4)烷基、二（Ci6烷基） 胺羰基（c】·4)烷基、三（c^4烷基μ夕烷基烷基、可 被（z】）p]取代之苯基（Ci 4)烷基、烷基、 烷基、Cm環烷基、cs-8鹵代環烷基、C2 6烯基（C3 8)環 烷基、C2·6鹵代烯基（c3 8)環烷基、c2 6烯基、c2_6鹵代 烯基、C2_6炔基、C2_6鹵代炔基、可被（zl)pi取代之笨基、 L或Μ ; R32表示氫原子、c^6烷基、CY6鹵代烷基或可被 _ (Z )P1取代之笨基，或者表示藉由R31與R32 一起形成 C2-5伸烷基鏈，並與鍵結之氮原子共同形成之3至6員 環，此時之伸烷基鏈可含有i個氧原子、硫原子或氮原 子，且可被鹵素原子、C〗·6烷基、ci6烷氧基、甲醯基、 c^6烷羰基、烷氧羰基或可被（zl)pi取代之苯基任意 取代； R表示氫原子、C&quot;烷基、被R35任意取代之（C“ 8)烷基、C,·8環烷基、C：3·8烯基、被R35任意取代之（c3_ 686 314918 200407073 8)烯基、C3_8炔基或被R35任意取代之（C3-8)炔基； K/4表示氫原子、Ci.6烧基、Cw鹵代院基、C3-8環 烷基（Cw)烷基、CV6烷氧基（CV4)烷基、CV6鹵代烷氧 基（Cw)烷基、c1-6烷硫基（Cw)烷基、cv6鹵代烷硫基 (cv4)烷基、Cw烷磺醯基（cv4)烷基、Cw鹵代烷磺醯 基（Cw)烷基、可被（z1)^取代之苯基（Cy)烷基或可被 (z1)〆取代之苯基； R35表示鹵素原子、氰基、硝基、c3_8環烷基、c3_ 8 鹵代環烷基、-OH、-OR36、-SH、-S(0)rR36、-NHR37、 -N(R37)R36、-CHO、-C(0)R31、-C(0)0R31、-C(0)SR31、 _C(0)NHR32、-C(0)N(R32)R31、-C(0)C(0)0R31、-CH = NOR11、-C(R9)=NORu、-Si(R13)(R14)R12、-P(〇)(〇R24)2、 •P(S)(OR24)2、-P(苯基）2、-P(〇)(苯基）2、可被（z1)^ 取 代之苯基、L或Μ ; R36表示cv6烷基、Cw鹵代烷基、cv6烷氧基（u 烷基、Cu烷硫基（c〗_4)烷基、可被（z1)^取代之苯基（Cb4) 烧基、c3_8環烧基、c3_8鹵代環烧基、c3_6稀基、c3_6 鹵代烯基、c3_8環烯基、c3-8鹵代環烯基、c3_6炔基、 C3_6鹵代炔基、-CHO、cv6烷羰基、cv6鹵代烷羰基、 Cu烧氧羰基、Cw鹵代烷氧羰基、Cw烷胺羰基、二 (Cw烧基）胺羰基、可被（zl)pi取代之笨羰基、C16烷胺 硫戴基、二（C】·6烷基）胺硫羰基、可被（21)?1取代之苯 基' L或]VI ; R37表示氫原子、C】.6烷基、c16鹵代烷基、c3 8環 687 314918 200407073 烧基、Cs.6烯基、c3-6炔基、C1-6烷羰基、CK6鹵代烷羰 基、CV6烧氧魏基、鹵代烧氧幾基、可被（z1)^取代 之苯氧羰基、可被（zi)pla代之苯羰基、c】.6烷磺醯基、 Ci_6鹵代烧石黃酿基、可被（Z )pl取代之笨基、l或μ， 或者表示藉由R36與R37 —起形成C2_5伸垸基鍵，並與 鍵結之氮原子共同形成之3至6員環，此時之伸烷基鏈 可含有1個氧原子或硫原子，且可被鹵素原子或甲基取 代； 1表示0至9之整數； m表示〇至4之整數； η表示〇至4之整數； Pi表示1至5之整數； P2表示〇至4之整數； P3表示〇至3之整數； P4表示〇至2之整數； p5表示〇或1之整數； ql表示〇至3之整數； q2表示〇至$之整數； q3表示〇至7之整數； q4表示〇至9之整數； r表示〇至2之整數；以及 1表示0或1之整數]。 如申凊專利範圍第1項之取代N-苯（甲）醯笨胺化合物或 其鹽，其中· 688 3)4918 2 200407073 X表示鹵素原子、氰基、硝基、-SF5、Ci.6燒基、 C]_6鹵代烧基、C2_6快基、Cu烧氧基、Cu鹵代烧氧基、 C1-6烧硫基、C〗_6鹵代烧硫基、c1-6烧亞石黃醯基、c 1-6 鹵代烷亞磺醯基、Ci_6烷磺醯基、C1-6鹵代烷磺醯基、 Cu烷氧羰基、C】·6烷胺羰基、二（Cw烷基）胺羰基或可 被（ζ1)Ρι取代之苯基，m表示2、3或4時，各個X可 彼此相同或相異， 再者’在2個X鄰接之情況，可藉由鄰接之2個X形 _ 成-CH2CH2CH2-、-CH2CH20-、-CH2〇CH2-、-OCH2〇-、 -CH2CH2S-、-CH2SCH2-、-ch2ch2ch2ch2-、-ch2ch2 ch2o-、-ch2ch2och2-、-CH2OCH2〇-、-0CH2CH20-、 •OCH2CH2S-或-CH=CHCH=CH-，且與各個所鍵結之碳 原子共同形成5員環或6員環，此時，形成環之各個碳 原子所鍵結之氫原子可被鹵素原子、C14烷基或ci-4鹵 代烧基任意取代； 又，G表示包含至少i個從氧原子、硫原子及氮原鲁 子中選出之原子且環内存在至少1個雙鍵之5員或6員 非务香力矢雜環時，X可另表示_N(R17)r16、_N = CHOR12 或-N=C(R9)〇r】2 ; Y表示_素原子、氰基、C16烷基、Cu鹵代烷基、 搜基（Ci·6)烷基、Ci·3烷氧基（c] 3)烷基、烷氧基、 C]_6鹵代烷氧基、0】6烷硫基、_代烷硫基、 烷胺基、一（Cw烷基）胺基、可被（zl)pi取代之苯基或可 被（z )p]取代之笨氧基，n表示2、3或4時，各個Y可 689 314918 200407073 彼此相同或相異， 再者，在2個γ鄰接之情況，可藉由鄰接之2個γ形 ic-CH2CH2CH2- &gt; -CH2CH2〇. &gt; -CH2OCH2- &gt; -OCH2〇., &gt;ch2ch2ch2ch2. &gt; -CH2CH2CH2〇. . -CH2CH2OCH2. &gt; -CH20CH20-、-〇ch2ch2〇-、-〇CH=NnCH=N…且 與各個所鍵結之碳原子共同形成5員環或6員環，此 %，形成環之各個碳原子所鍵結之氫原子可被鹵素原 子、c^4烷基或c14鹵代烷基任意取代； 鲁 R1及R2各自獨立，分別表示氫原子、烷基、 鹵代烷基、Cl_4烷氧基（Ci·4)烷基、Ci 4鹵代烷氧基 (U烷基、c】_4烷硫基（c^)烷基、Ci 4鹵代烷硫基 烧基Ci-4烧石κ 基（C1-4)烧基、cl-4鹵代烧磺醯基（q 4)烷基、可被（ζ1)^取代之苯硫基（Ci4)烷基、C3_6烯基、 C3.6鹵代烯基、Cs_6炔基、c3_6鹵代炔基、Cw烷硫基、 Cu鹵代烷硫基、可被（z1)^取代之苯硫基或- SN(R2〇) p 19 · ▲ 3 一 · R3表不C】_8烷基、被Ru任意取代之烷基、 C3-8環烷基、Cw烷硫基（C3·6)環烷基、Ci4烷亞磺醯基 ((：3.6)裱烷基、C〗·4烷磺醯基⑴3·6)環烷基、羥曱基（Ch) 環烷基、CV4烷氧曱基（c3 6)環烷基、Ci 4烷硫甲基（q. j環烧基、Cw燒亞磺醯甲基（Cy)環烷基、ci 4烷磺醯 甲基（C3_6)環烷基、c3-8烯基、ci 6烷胺羰基（c3 6)烯基、 玎被（Z])pl取代之笨基（(：3·6)烯基、c38炔基、可被（z】）pi 取代之笨基（〇3·6)炔基、萘基（u炔基、L&lt;Cu)炔基、 690 314918 200407073 Ci_8 烷氧基、C3_8 鹵代烯氧基、M-4、M-5、M-8、M-9、 M-13 至 M-19、M-21、M-22、M-2 5 或 M-28，或者藉由 R2與R3 —起形成C2_6伸烷基鏈，並與鍵結之氮原子共 同形成之3至7員環，此時之伸烷基鏈可含有1個氧原 子或硫原子，且可被Cy烷基任意取代； R4表示氫原子、鹵素原子、Cw烷基、C&quot;鹵代烷 基、被R23任意取代之烷基、被R23任意取代之（C】_6) 鹵代烷基、C3_8環烷基、C3_8鹵代環烷基、被R23任意 _ 取代之（C3_8)環烷基、被R23任意取代之（C3_8)鹵代環烷 基、c3_6稀基、c3.6鹵代烯基、c3_6炔基、c3_6鹵代快基、 -OR8、-S(0)rR8、-N(R1G)R9、C1-6 烷氧羰基、-CH=NOR&quot;、 -C(R9)，〇rii …Si(R13)(R14)R12、-P(〇)(〇R24)2、可被 (Z2)P]取代之苯基、1-萘基、2-萘基、L或Μ ; R5 (a)G表示含有至少1個從氧原子、硫原子及氮原子中選 出之原子且環内存在至少1個雙鍵之5員或6員非芳香 _ 族雜環或者含有2個從氧原子、硫原子及氮原子中選出 之原子之5員或6員飽和雜環時，R5表示氫原子、鹵素 原子、氰基、CV6烧基、Cb6鹵代烧基、被R23任意取 代之（ci-6)烷基、被R23任意取代之（C&quot;)鹵代烷基、C3.8 壤燒基、C3.8鹵代環烷基、被r23任意取代之（C3_8)環烷 基、被R23任意取代之（C38)鹵代環烷基、C36烯基、C36 代稀基、c36炔基、c36鹵代炔基…〇r8、-S(0)rR8、 •N(R1Q)R9、-CHO、-C(0)R9、-C(0)0R9、-C(0)SR9、一 69] 314918 C(O)N(R10)R9、-C(S)N(R，r9、-CH=NORn、-C(R9)二 NOR11、可被（Z2)pl取代之苯基、i-萘基、2-萘基、L或 Μ ； (b) G表示3員至6員之環烷基環且R4表示氫原子、鹵 素原子、CV6烧基或Cw鹵代烧基時，R5表示氰基、被 R23任意取代之（Cu)烷基、被R23任意取代之（cv6)鹵代 烷基、c3_8環烷基、C^8鹵代環烷基、被R23任意取代 之（c3_8)環烷基、被R23任意取代之（c3_8)鹵代環烷基、 C3_6烯基、C3_6鹵代烯基、c3_6炔基、c3.6鹵代炔基、-OR8、_S(0)rR8、-N(R10)R9、-CHO、-C(0)R9、-C(0)0R9、 -C(0)NHR10^ -C(O)N(R10)R9 &gt; -C(S)NHR10 ^ -C(S)N(R10) R9、-CH=NORu、-C(R9)=NORn、-Si(R13)(R14)R】2、可 被（Z2)pl取代之苯基、1-萘基、2-萘基、L或M ; (c) G表示3員至6員之環烷基環，且R4表示氰基、被 R23任意取代之（Cb6)烷基、被R23任意取代之（C^)鹵代 烷基、C3_8環烷基、C3.8鹵代環烷基、被R23任意取代 之（C3_8)環烷基、被R23任意取代之（C3_8)鹵代環烷基、 C3_6烯基、C3.6鹵代稀基、C3.6炔基、C3_6鹵代快基、-OR8、-S(0)rR8、-N(R1G)R9、C]_6 烷氧羰基、_Si(R13)(R14) R12、-P(0)(0R24)2、可被（Z2)pl 取代之苯基、1-萘基、2-萘基、L或]V[時，R5表示氫原子、鹵素原子、氰基、 烷基、（^.6鹵代烷基、被R23任意取代之（Ci.6)烷基、 被R23任意取代之（CN6)鹵代烷基、C3_8環烷基、C3_8鹵 代環烷基、被R23任意取代之（c3-8)環烷基、被R23任意 692 314918 200407073 取代之（C：3·8)鹵代環烷基、c3_6烯基、c3_6鹵代烯基、C3-6 炔基、C3-6 鹵代炔基、-OR8、-S(0)rR8、-N(R10)R9、-CHO、 -C(0)R9 ^ -C(0)〇R9 . -C(0)NHR10 &gt; -C(〇)N(R10)R9 &gt; - C(S)NHR10、-C(S)N(R10)R9、-CH=NORu、-C(R9) = NOR11、-Si(R13)(Ri4)Rl2、可被（Z2)pi 取代之苯基、^萘 基、2-萘基、L或M ; R6表示氫原子、鹵素原子、氰基、Cl.6烷基、C&quot; 鹵代烷基、被R23任意取代之（Cu)烷基、被r23任意取鲁 代之（C^6)鹵代烧基、（23_8環烧基、C3_8鹵代環烧基、被 R23任意取代之（Cs_8)環烷基、被R23任意取代之（C3 8) 鹵代環烷基、-s(o)2r9、C&quot;烷羰基、cv6鹵代烷羰基、 可被（Z1)^ 取代之苯羰基、-C(0)0R9、-C(0)SR9、-C(O) N(R1G)R9、二（C〗·6烷基）磷醯基、二（Ci6烷基）硫代磷醯 基、可被（Z2)pl取代之苯基、L或M;或者在R6與R4 鄰接之情況，可表示藉由鄰接之R4及R6 一起形成C3 5 伸烧基鏈，並與鍵結之原子共同形成之5至7員環；此 _ 時之伸烷基鏈可包含1個氧原子或硫原子，且可被c i _ 6烷基任意取代； z2表示鹵素原子、氰基、硝基、胺基、Ci 6烷基、 c]_6鹵代烷基、Cw烷氧基（Ci 3)烷基、Ci 3鹵代烷氧基 (C】_3)烷基、Cw烧硫基（C1-3)烷基、ci-3鹵代烷硫基（C1-3) 烧基、C】·3烧亞續醯基（C^)烷基、c]_3鹵代烷亞磺醯基 (Cu)烷基、Cw烷磺醯基（Ci 3)烷基、3函代烷磺醯 基（(：】·3)烧基、氰基（C^)烷基、羥基〇鹵代烷基、c】_3 693 314918 200407073 烧氧基（CY3)鹵代烷基、cv3鹵代烷氧基（cv3)鹵代烷 基、環烷基、c3_8鹵代環烷基、Cw烷氧基、cv6 ώ代烷氧基、Cw鹵代烷氧基（(^_3)鹵代烷氧基、Cw烷 確醯氧基、Cw鹵代烷磺醯氧基、可被（z1)^取代之苯 氧基、-0(L-45)、CV6烷硫基、CV6鹵代烷硫基、C3.8 環烷硫基、可被（Z1)^取代之苯硫基、-S(L-45)、C】_6烷 亞磺醯基、Cw鹵代烷亞磺醯基、C3_8環烷亞磺醯基、 可被（Z1)^取代之苯亞磺醯基、-S(0)(L-45)、Cw烷磺 醯基、Cw鹵代烷磺醯基、C3_8環烷磺醯基、可被（zi)pl 取代之苯磺醯基、-S02(L-45)、CV6烷胺基、二（Cu烷 基）胺基、烷胺磺醯基、二（Cb6烷基）胺磺醯基、 1-6 烷磺醯胺基、Cu鹵代烷磺醯胺基、-C(0)NH2、Cw垸 胺羰基、二（Cu 烷基）胺羰基、-C(S)NH2、-Si(R15)(Ri6) R14、可被（Z〗）pl 取代之苯基、L-5、L-14、L-24、L-3 6、 L-3 9、L-41、L-42、L-43、L-44 或 M，pl 表示 2 以上之 整數時，各個Z2可彼此相同或相異； 再者，在2個Z2鄰接之情況，可藉由鄰接之2個z2妒 成-CF2CF20-、-CF2OCF2-或-〇cf2o-並與各個所鍵結之 碳原子共同形成5員環； R8表示C】-6烷基、cv6鹵代烷基、c3_8環烷基（c】 4)烷基、C3_8環烷基、C3.8鹵代環烷基、C2-6烯基、c 2 · 6 鹵代稀基、C3 _8環稀基、C3 _8鹵代環稀基、c 3 _ 6块基、 c3.6鹵代炔基、可被（Z])pl取代之苯基、L或Μ ; R9表示C〗-6烧基、Cw鹵代烧基、（^^環；)：完基（c 314918 694 4)垸基、可被（ζι)ρΐ取代之苯基（Cw)烷基、L-CCVJ烷 基、烷基、C3-8環烷基、c3_8鹵代環烷基或可被 (Z1)P1取代之笨基； R1G表示氫原子或C】_6烧基，或者表示藉由R9與 R1() 一起形成C2_6伸烷基鏈，並與鍵結之氮原子共同形 成之3至7員環，此時之伸烷基鏈可含有1個氧原子或 硫原子； R11表示氫原子、c烧基、c鹵代烧基或可被 (z])pl取代之苯基（CV4)烷基，或者藉由R9與R&quot; —起形 成crC3伸烷基鏈，並與鍵結之原子共同形成5或6員 環，此時之伸烷基鏈可含有1個氧原子、硫原子或氮原 子’且可被（^.6烷基任意取代； R12表示Ci.6烷基或可被（ζ1、】取代之苯基； R13及R14各自獨立，表示C】_6烷基； R15表示C】·6烷基、Ci_6鹵代烷基、可被（z1)^取代 之笨基（c^)烧基或可被（z1)^取代之苯基； R16表示氫原子、c】·6烷基、Cw環烷基（Ci_4)烷基、 ci-4烷氧基（Cb4)烷基、Cw烷硫基（c“4)烷基、c3.6環烷 基、c3_6烯基、C3_6鹵代烯基、c3.6炔基、c3.6鹵代炔基、 C1-6烧績醯基、代烧磺醢基、_(31^0、-〇^0)119、- C(0)〇R9、-C(0)SR9、-C(〇)N(R1Q)R9、-C(S)OR9、-C(S)SR9 或-C(S)N(R1())R9 ; R”表示氫原子或C】.6烷基，或者藉由尺”與R2 一 起形成Cu伸烷基鏈，並與鍵結之原子共同形成與苯環 314918 695 200407073 稠合之0員或7員雜環，此時之伸烷基鏈可被Ci6烷基 任意取代； 义18表示鹵素原子、氰基、（：3_6環烷基、-〇1128、- N(R29)R28、-SH、-S(〇)rR30、_CH〇、Cl 6 烧羰基、C&quot; 垸氧羰基、_C(0)N(R32)R31、-c(R34)=NOH、-c(r34) = N〇R33、-Si(Rl3)(Rl4)Ri2、可被（zi)pl 取代之苯基、、 L-2、L-3 、 L-4 、 L-45 、 L-46 、 L-47 或 Μ ; _ Rl9表示ci-6烷基、Cw烷氧羰基（CV4)烷基或Cw ® &amp;氧羰基； R表示C!·6烧基，或者表示藉由尺19與R2〇 一起形 C4·5伸烷基鏈，並與鍵結之氮原子共同形成之5員環 或6員％，此時之伸烷基鏈可含有丨個氧原子或硫原 子’且可被甲基或甲氧基任意取代； R23表示氰基、Gw環烷基、c3 8 ^代環烷基、 巩基、C〗·6鹵代烷氧基、可被（z】）pi取代之苯氧基、 烷硫基、可被（ζι)ρ1取代之苯硫基、Ci 6烷磺醯基、_ _代烷磺醯基、可被（ζι)ρΐ取代之苯磺醯基、6 垸氣羰基、Cw鹵代烷氧羰基、二（Ci 6烷基）胺羰基、-Si〇^)(R]4)R〗2、可被（z】）pi取代之笨基、L或M; 汉表示c].6烧基、c^·6鹵代烧基或c16垸氧基， ql、q2、q3或q4表示2以上之整數時，各個R25可彼 &amp;相同，亦可彼此相異； ^ R26表示-CHO、0】.6烷羰基、C】.6烷氧羰基、 少元胺羰基、二（Cl·6烷基）胺羰基、可被（ζι)ρ】取代之苯^炭 314918 696 200407073 基、Ci_6烷磺醯基或鹵代烷磺醯基； R28表示氫原子、CV6烧基、CV6鹵代烧基、C!_4炫 氧基（Cw)烷基、cv4烷硫基（cv4)烷基、可被（z1：^取代 之苯基（U烷基、〇:3.8環烷基、c3.8烯基、c3_8炔基、 -CHO、C1-6烧獄基、C1-6鹵代烧羧基、03_6環烧戴基、 可被（冗^…取代之苯羰基、CV6烷氧羰基、-C(0)N(R32) R31、-C(S)N(R32)R31、CV6烷磺醯基、Cb6鹵代烷磺醯 基、可被（冗”…取代之苯磺醯基、二（Cw烷基）胺磺醯 基、一（C1-6烧基）填&amp;&amp;基、二（Ci.6烧基）硫代填隨基、_ Si(R13)(R14)R12或可被（z1)^取代之苯基； R29表示氫原子、Ci_6烧基或（^_6烷氧基； R3G表示Cu烷基、被R35任意取代之（Cw)烷基、 C3.6環烷基、c3_6烯基、（：3·6炔基、Cu烷硫基、可被（z1)^ 取代之苯硫基、C!·6烷羰基、烷胺羰基、二（Cw烷 基）胺羰基、Cw烷胺硫羰基、二（Cl_4烷基）胺硫羰基、 可被（Z1：^ 取代之苯基、L-21、L-3 5、L-45 或 L-48 ; R31表示CV6烷基、C1-6鹵代烷基、c3.8環烷基（Cm) 烧基、Cw烧氧基（cv4)烧基、c1-4烧硫基（(^·4)烷基、 可被（ζ〗）ρ】取代之苯基（Cl-4)烷基、（1^45)- (Ci 4)烷基、 (L-46)- (Cl.4)烷基、（1^47)-(&lt;3】_4)烷基、（：3.6環烷基、c3_6 烯基、C2·6炔基、或可被（z】）pl取代之苯基； R32表示氫原子或C〗·6烷基，或者表示藉由rm與 R32 一起形成CM伸烷基並與鍵結之氮原子共同形成之 3至6員環，此時之伸烷基鏈可含有1個氧原子、硫原 314918 697 200407073 子或氮原子，且可被Ci 6烷基、ci 6烷氧基、甲醯基、 Ci-6燒羰基或Cw烷氧羰基任意取代； R33表示CV6烷基、c3.6環烷基（Cl.4)烷基、炫 氧基（c!_4)烷基、c1-4烷硫基（u烷基、Cw烷氧氣基 (Cl-4)烷基、二（C1-4烷基）胺羰基（Cw)烷基、C3_6稀基或 可被（z〗）pl取代之苯基（c】_4)烷基； 表示氫原子、Cu烧基或可被(z1)^取代之表 基； R35表示鹵素原子、-OH、CV4烷氧基、C】-6烷羰氧 基、cv4鹵代烷羰氧基、CV4烷硫基、CV4烷羰基、Cl_ 4烷氧羰基、二（C1-4烷基）胺羰基、-Si(R13)(R14)R12或可 被（Z])pl取代之苯基。 3 ·如申請專利範圍第2項之取代N-苯（甲）醯苯胺化合物或 其鹽，其中： G表示式G -1、式G - 4、式G - 5、式g - 6、式G - 7、 式 G-8、式 G-11、式 G-12、式 G-13、式 G_i4、式 G-15、式 G_17、式 G-18、式 、式 G-22、式 G-23、 式 G-32、式 G-33、式 G-40、式 G-41、式 g_42、式 〇_53 或式G-54之任一者表示之非芳香族雜環，式G_55或式 G-56表示之飽和雜環或式G-7 1表示之琴产某環· 314918 698 200407073 R5
    R6c ^ G-6 〇Λ_
    R6a R«b G-7 R5 G-13 R5 s G-18
    卦。7 s G32 R5
    R5
    R5
    R5
    G-33 G-22
    G-41 R5 R6c
    699 314918 200407073
    Ό
    G-71 G-55 W1及 G-56 W2表示氧原子； v本系鹵素原子 '硝基、C 检：a： ^ X表7、〜 h-6烷基、1_6函代烷基、 c“烷氧基、Cl’6鹵代烷乳基、c“烷硫基、Ci 6鹵代烷 硫基、烷亞舶I基Ci·6 i代烷亞磺醯基、烷 磺醯基或h-6 丞m表不2或3時，各個X 玎彼此相同或相異， 再者，在2個X郝接之情況，可由1 再务 、 4猎由鄰接之2個X形 成 _〇CF2〇-或 _〇CF2CF2〇-，且盘久 /、各個所鍵結之碳原子丘 同形成5員環或6員環； 、/' 又’G表不以式G-1、r &gt;1 式G-4、式G-5、式G_6、式 G-7、式 G-8、式 G-11、式 rj 丨？ ^ 51 飞 Cj-12、式 Gqg、彳 r 1 ζΐ 式G]5、式匕17、式G_u、 式Ο·〗4、 ^ Γ ^ 飞 G·21、式 G-22、式 G-23、 式 G-32、式 G_33、式 G 4〇、 ^ 〇 或式G-54之任—去# _ 、式G-42、式G-53 - XT t表777之非芳香族雜王^士 V 口 士 不-N(RI7)R】6 ; 日伤滩％日守，X另可表 Y表不齒素原子、c (Cl-6)烷基、C ^ - ]·6烷基、鹵代烷基、羥基 烷硫基，11表示2 70基、C】-6烷氧基或c】·6 異； 。個丫可彼此相同或彼此相 R1表示氫原子； 314918 700 200407073 R2表不氫原子、C!·6烷基、ci 4烷氧基（C1_4)烷基或 C3.6烯基； R3表示Cw烷基、被任意取代之（Cw)烷基、 CM環烷基·、c：3·8烯基、c!·6烷胺羰基（C3 6)烯基、可被 (z1)^取代之笨基（c3_6)烯基、03 8炔基、可被（zl)pi取 代之苯基（C3_6)炔基、奈-1-基（C36)炔基、萘_2_基 炔基、（L-1)-(C3_6)炔基、（L-2)-(C3_6)快基、（L-3)-(C3_6) 快基、（L-4HC3_6)炔基、（L-45)-(C3_6)炔基、（l_46HC3_6)春 炔基、（L-47)-(C3_6)炔基、M-4、M-5、M-8、M-9、M- 13至M-19、M-21或M-22，或者表示藉由…與r3 一 起形成Cm伸烷基鏈並與鍵結之氮原子共同形成之3至 7員環，此時之伸烷基鏈可含有丨個氧原子或硫原子； R4表示氫原子、Cw烷基、ci-6鹵代烷基、c3_6環 烷基（Cw)烷基、cs·6鹵代環烷基（Ci 4)烷基、cl 4烷氧 基（Cw)烷基、ον#鹵代烧氧基（c14)烷基、c1-4烷硫基 (ci-4)院基、Ci·4鹵代烧硫基（c]_4)：)：完基、Ch烧亞石黃醯 鲁 基（C〗_4)烧基、C】_4鹵代烧亞石黃驢基（ci4)烧基、Cm：)：完 磺醯基（Cw)烷基、c 1-4 鹵代烷磺醯基（cle4)烷基、氰基 (CW)烷基、Cw鹵代烷氧基（Uil代烷基、〇：3.8環烷 基、C3-8 鹵代環烷基、-CH=N〇Rn、-(^(Rq^NOR】1、可 被（Z2)p]取代之苯基、1-萘基、2-萘基、L-1至L-4、L-8 至 L-13 、 L-15 至 L-23 、 L-25 至 L-35 、 L-37 、 L-38 、 L-40、L-43 至 L-58、M-4、M-5、M-8、M-9、M-14 至 M-18 或 M-19 ; 314918 701 又，G為以G-71表示之但ιΛ。士 之％烷基％日寸，R4可以另 表不鹵素原子、q 6烷氧其 石六其、广 6虱基、Cw鹵代烷氧基、Ci6烷 瓜土、Cl-6鹵代烧硫基、C ^ ^ ^ A 亞碏酽I K6垸亞石頁基、c1-6鹵代烷 亞-蜢基、Ci_6烷磺醯基或 Λ说π廿龄* X 鹵代烷石頁醯基、 R5 (a)G 為以式 G-4、式 G-5、式 r 6 4 Γ 7 4 ^ , 八 G-6、式 G-7、式 G-8、式 、式 G-12、式（}-13、式 ^ Γ ic jl 八 G-14、式 G-15、式 G-17、 式匕18、式G-21、式G-22、式r π 4 r w』 式 G-23、式 G-32、式 G-33、 式 G-40、式 g-41、式 G-42、 一 z 式G-53或式G-54之任一 者表示之非芳香族雜環， 么4以式G-55或式G-56表示之 飽和雜環時，R5表示氫 、 社原子、_素原子、氰基、C]_6烷 土、C“由代烷基、C3·6環烷基（C&quot;)烧基、C3_6鹵代環 烧基14)烧基、Cl_4烧氧基（c“）烧基、_代烧氧 基（c!·4)烷基、Cw烷硫基（Ci 4)烷基、c】_4鹵代烷硫基 (Cw)烷基、Ci_4烷亞磺醯基（u烷基、4鹵代烷亞 磺醯基（U烷基、c】_4烷磺醯基（Ci 4)烷基、c】_4鹵代 烷磺醯基（CV4)烷基、氰基（Ci6)烷基、c3 8環烷基、c3 8 鹵代環院基、Cw烷氧基、Cw鹵代烷氧基、可被（ζι)ρι 取代之苯氧基、CN6烷硫基、c】4鹵代烷硫基、可被（ζι)ρι 取代之苯硫基、烷亞磺醯基、cN6鹵代烷亞磺醯基、 可被（Z1)^取代之笨亞磺醯基、c】_6烷磺醯基、c^6鹵代 烷磺醯基、可被（z])p]取代之苯磺醯基、Cw烷胺基、 二（C1.6烧基）胺基、π比嘻炫-1 -基、曙。坐烧-3 -基、嚷唾烧 -3-基、哌啶-1-基、嗎福啉-1-基、-C(0)R9、-C(0)0R9、 702 314918 200407073 -C(〇)SR9、_c(0)n(r”）r9、_C(S)N(R10)R9、_ch=n〇r11、 -C(R9)=NORH、可被（Z2)pl取代之笨基、丨_萘基、2_萘 基、L或Μ ; (b) G為以G-71表示之環烷基，且R4表示氫原子、鹵素 原子、烷基或C!_6鹵代烷基時，R5表示氰基、 環烷基（CV4)烷基、cs_6鹵代環烷基烷基、Ci 4烷 氧基（Cw)烧基、C!·4鹵代烷氧基（Ci 4)烷基、Ci 4烷硫 基（(^_4)烷基、Cm鹵代烷硫基烷基、Ci 4烷亞磺 參 醯基（Ch)烧基、Cw鹵代烧亞磺醯基（C14)烷基、Ci 4 烧磺酿基（C^4)烧基、c^4鹵代烧石黃醯基（C14)烧基、氰 基（Cb6)烧基、（33_8環烧基、c3_8鹵代環烧基、可被（z〗）pi 取代之苯氧基、可被（zypl取代之苯硫基、可被（zl)w 取代之苯亞磺酸基、可被（z1)^取代之苯績醯基、_ CHO、-C(0)R9、-C(0)〇R9、-C(0)NHR10、-C(O)N(R10)R9、 -C(S)NHR10、-C(S)N(R10)R9、CHsNOR】1、-C(R9) = NOR11、-Si(RI3)(R】4)R12、可被（z2)pl 取代之苯基、^蔡 _ 基、2-蔡基、L或Μ ; (c) G為以G-71表示之環烧基，且R4表示c36環烧基 (cv4)烷基、c3-6鹵代環烷基（Cl-4)烷基、c14烷氧基（U 烷基、CV4鹵代烷氧基（c】·4)烷基、Cw烷硫基（u烧 基、C^4鹵代；!：完硫基（c】·4)烧基、C〗·4燒亞石黃酿基（c】4) 烷基、C!-4鹵代烷亞磺醯基（Ci4)烷基、C^4烷磺醯基（c] 4) 烷基、c】·4鹵代烷磺醯基（Ci·4)烷基、氰基(Ci 6)燒基、 C]·4鹵代烷氧基（h·4)鹵代烷基、C3·8環烷基、c3 8鹵代 314918 703 環烧基、c1-6烷氧基、Cw i代烷氧基、cv6烷硫基、 ci·6鹵代烷硫基、Cw烷亞磺醯基、c】_6鹵代烷亞磺醯 基、Cu烧績酿基、Cu鹵代烧續醯基、可被（z2)P1取代 之苯基、：U萘基、2-萘基、L-1至L-4、L-8至L-13、L-15 至 L-23、L-25 至 L-35、L-37、L-38、L-40、L-43 至 L-58、 M-4 ' M-5、M-8、M-9、M-14 至 M-18 或 M-19 時，R5 表示氫原子、鹵素原子、氰基、（^_6烷基、鹵代烷 基、C3^環烷基（c1-4)烷基、c3_6鹵代環烷基（cv4)烷基、 Ci_4烧氧基（Cw)烧基、Cw鹵代烧氧基（Cw)烧基、 4烧硫基（cv4)烷基、cv4鹵代烷硫基（cv4)烷基、Ci_4烷 亞磺酿基（c1-4)烷基、（^_4鹵代烷亞磺醯基（(^_4)烷基、 C1-4烧石頁酉迪基（c】_4)烧基、Cw鹵代烧石黃酿基（C1-4)烧基、 氰基（c^)烷基、c3-8環烷基、c3-8鹵代環烷基、cv6烷 氧基、鹵代烷氧基、可被（zi)pl取代之苯氧基、Cl_ 6烧硫基、Cw鹵代烷硫基、可被（z1)^取代之苯硫基、 C1·6烷亞磺醯基、Cw鹵代烷亞磺醯基、可被（z1)^取代 之苯亞績醯基、C〗_6烷績醯基、il代垸磺醯基、可 被（Zi)pl 取代之笨磺醯基、-CHO、-C(0)R9、-C(0)0R9、 -C(0)NHR】〇、-C(O)N(R10)R9、-C(S)NHR10、-C(S)N(R】〇) R9、-CH=NORn、-C(R9)=NORn、_Si(R13)(R14)R12、可 被（Z~)pl取代之苯基、i_萘基、2 -萘基、L或M; R6a、R6b、R6c及R6d各自獨立，表示氫原子、鹵素 原子、氰基、CN6烷基、c】_6鹵代烷基或可被（z2)pi取代 之笨基； 704 314918 200407073 R6e表示氫原子、Cu烷基、C!-6烷磺醯基、南 代烧磺醯基、可被（ζι)ρΐ取代之苯磺醯基、cl 6烷羰基、 CV6鹵代烧羰基、可被（Zi)pi取代之苯羰基、Ci_6烷氧幾 基、Cw鹵代烧氧羰基、可被（ζι)ρΐ取代之苯氧羰基、 二（C!·6烷基）磷醯基或可被（Z2)pi取代之笨基； R6f、R6g及R6h各自獨立，表示氫原子、Ci6烷基、 Cu鹵代烧基或可被（z2)pi取代之苯基； R61表示氫原子、鹵素原子、氰基、C16烷基、c % i代烧基、Cw烷氧羰基或Ci 6鹵代烷氧羰基； R6j及R6k各自獨立，表示氫原子、鹵素原子、氰基、 Cu烧基或CV6 _代烧基； Z2表示鹵素原子、氰基、硝基、胺基、烷基、 鹵代烷基、Cm烷氧基（Ch)烷基、c〗·3鹵代烷氧基 (CV3)烷基、c1-3烷硫基（Ci 3)烷基、Ci 3鹵代烷硫基（c] ^ 烷基、c〗_3烷亞磺醯基（Ci·3)烷基、Ci_3鹵代烷亞磺醯基 (C〗·3)烷基、C〗·3烷磺醯基（Ci_3)烷基、Ch鹵代烷磺醯 _ 基（(^_3)烷基、氰基（C16 )烷基、c38環烷基、鹵代 環烷基、C〗_6烷氧基、Ci_6鹵代烷氧基、鹵代烷氡 基（C】_3)鹵代烷氧基、Ci_6烷磺醯氧基、鹵代烷磺醯 氧基、可被（Z%〗取代之苯氧基、_0(L_45)、Ci6烷硫基: Cu鹵代烷硫基、C：3·8環烷硫基、ci 6烷亞磺醯基、C! 6鹵代烷亞磺醯基、C：3·8環烷亞磺醯基、Ci 6烷磺醯基^ C ] · 6鹵代少兀石男&amp;&amp;基、C 3 _ 8環烧磺酸基、c】· 6烧胺基、一 (C】·6烷基）胺基、Cw烷胺磺醯基、二（Cw烷基）胺磺醯 314918 705 土、&lt;(〇)ΝΗ2、C】·6烷胺羰基、二（Cb6烷基）胺羰基、 C(S)NH2或三（Cb6烷基）矽烷基，pi表示2以上之整數 B 士 T ’各個Z2可彼此相同或相異； 再去 JL. 方，在2個Z2鄰接之情況，可藉由鄰接之2個z2形 -JL&gt; —並與各個所鍵結之碳原子共同形成$員環； R9表示C&quot;烷基、C〗-6鹵代烷基、可被（ζι)取代 本基（C!-4)烧基、C3·8環烧基、或可被（Z!)〗取代之苯 基； P 表示氫原子或Ch烧基’或者藉由R9與Rl〇 一 員二成CfC：5伸烷基鏈，並與鍵結之氮原子共同形成5 2 ^或6員環，此時之伸烷基鏈可包含丨個氧原子或硫 之#R1表示烷基、Cw鹵代烷基或可被（zl)pi取代 伸=基（Ck4)烧基’或者表示藉由R9# R&quot; 一起形成C&quot; :基鏈’並與鍵結之原子共同形成5 M環或6員環， 可之伸烷基鏈可被Ci_6烷基任意取代； R二表示烷基或可被（ζι)ρΐ取代之苯基； 二16表示氫原子、CK6烧基、c14烷氧基(c&quot;)烷基、 烷硫基（C] 4)烷基、_CH〇、 ^ U况叛基、c1-6鹵代烷 反土 C3 -6 ϊ哀烧罗炭基、c 按童势1 ^ A 〇 ^丨-6烷虱叛基、C丨-6鹵代烷氧羰 土或c丨· 6烧硫幾基； ,17表示氫原子或L烷基，或者汉17與R2可一起 形成- CH2-; R18表示齒素原子、氰基、C“環烧基、-〇R28… 314918 706 200407073 N(R29)R28、_s(〇)rR3〇、Ci 6 烷氧羰基、_c(〇)n(r32)r3]、 _c(R34)=NOH、-C(R34)二⑻1133、三（Cw 烧基）石夕烷基、 可被（Z1)P1 取代之苯基、L-l、L-2、L-3、L-4、L-45、 L-46、L-47 或 M ; R25表示cv4烷基； R表不c]_6烧魏基或c1-6燒氧魏基； R28表示氫原子、Cw烧基、Cw鹵代烷基、〇v4烷 氧基（Cw)烷基、Cb4烷硫基（CK4)烷基、可被（ζι)ρΐ取代 之苯基（C〗·4)烷基、c〗_6烷羰基、C3-6環烷羰基、（：卜6烷 氧羰基、-c(0)n(r32)r31、CY6烷磺醯基、二（Ci 6烷基） 胺績酿基、可被^。^取代之笨磺醯基、二（Ci_6烷基） 恤^基、二（Cl·6烷基）硫代磷醯基、三（Cw烷基）矽烷基 或可被（z1)^取代之苯基； R2 9表示氫原子或（^_6烧基； R表不C〗_6烧基、Cu鹵代烷基、羥基（CI_4)烷基、 ci-4烷氧基（CU4)烷基、Cw烷硫基（Cw)烷基、Ci 4烷羰 基（Cw)烷基、烷氧羰基（U烷基、二（Ci4烷基） 胺羰基（U烷基、三（Ci_4烷基）矽烷基（ 某、可 被（Z】）pl取代之苯基（c】.4)烷基、c3 6烯基、基、 cv6烷硫基、可被（ζι)ρΐ取代之苯基、L_21或L_45 ·， R31表不Ci.6烷基、Ci 4烷硫基（Ci 4)烷基、可被（zl)p】 取代之苯基（Cw)烷基、Gy環烷基、c36烯基或可被 (z])p】取代之苯基； R32表示氫原子或Cl·6烷基，或者表示藉由與 314918 707 200407073 I元成Cw伸烧基鏈’並與鍵結之氮原子共同形 成之3至6員環，此時之伸烷基鏈可含有丨個氧原子 硫原子； R表不Cu烷基或可被（z〗）pi取代之苯基（Ci4)烷 衣不氧原子或Cw烷基； m表示0至3之整數； n表示〇至3之整數； q2表示〇至3之整數； q3表示〇至2之整數；以及 q4表示〇至2之整數。 月專利範圍第3項之取代N-苯(甲)醯苯胺化合物 其鹽，其中： / G表示式G-4、式G_5、式G_6、式G_7、式gu、 式 G-13、式 G_14、式 G_15、式 G i7、式 g i8、式匕：工、 式G-22或式G_23之任一者表示之非芳香族雜環，或式 G-71表示之環烷基環； X表示表示i素原子、石肖基、基、代 烧基、Cl.4烧氧基、Ci 4i錢氧基、c&quot;烧硫基、^ 4鹵代烧硫基、c,.4烧亞續醯基、Cd代烧亞續酿基:· Cl.4烧石黃酿基或Cl.4處刪酿基’ m表示2時，各個 X可彼此相同或彼此相異； Y表示齒素原子、Cl_4烧基、Ci4函代烷基、k 烧氧基或C&quot;烧硫基，n表示2或3時，各個γ可彼此 314918 708 相同或彼此相異； R2表示氫原子或Cw燒基； R3表示Cm烷基、被R18任意取代之（Ci 8)烷基、 C3.8烯基或C3_8炔基； R4表示氫原子、C&quot;烷基、Ci 6鹵代烷基、c3.6環 烷基（c!·4)烧基、Cw烷氧基（c1-4)烷基、cv4鹵代烷氧 基（c】_4)烷基、Cw烷硫基（CY4)烷基、Cl_4鹵代烷硫基 (Cw)烷基、C3-8環烷基、C3-8鹵代環烷基、可被（Z2)叫 取代之苯基、2-萘基、L-1至L-4、L-15至L-17、L-19、 L-20、L-22、L-23、L-45 至 L-47、L-50、M-4、M-5、 M-8、M-9、M-14 至 M-18 或 M-19 ; 又，G為以式G-71表示之環烷基環時，R4可以另 外表不鹵素原子、Ci·6烷氧基、Gw鹵代烷氧基、 烷硫基、代烷硫基、Ci·6烷磺醯基或6齒代烷 石黃酿基， R5 (a)G為以式G-4、式G-5 式 G·13、式 G-14、式 G-15、式 G_17、式匕18、式 G_2i 式G-22或式G_23之任一者表示之非芳香族雜環時，正 表示氫原Ή素原子、氰基、c“6烧基、c&quot;嶋 基、c3.6環烧基（Ci.4)燒基、Ci』氧基I)烧基、c 4函代烧氧基U烧基U硫基(C]HC_ 代烧硫基（cK4m基、Ci.A亞相基（Cl·狀基、 齒代烧亞石黃酿基（C1.4)烧基、U伽基心烧基: 314918 709 200407073 C^4鹵代烷磺醯基（q·4)烷基、c3_8環烷基、C3-8鹵代環 烷基、Cu烷氧基、鹵代烷氧基、cl 6烷硫基、 6鹵代烷硫基、Cw烷亞磺醯基、Ci 6鹵代烷亞磺醯基、 C卜6烧石頁醯基、C i _ 6鹵代烧石黃酿基、二（c i 6炫基）胺基、 吡咯烷-1-基、_唑烷-3-基、噻唑烷基、哌啶-1-基、 嗎福啉-1-基、-(^(R^NOR11、可被（Z2)pi取代之苯基、 1 -蔡基、2 -蔡基、L、Μ - 4、Μ - 5、Μ - 8、Μ - 9、Μ -14 至 Μ-1 8 或 Μ-1 9 ; · (b) G為以G-71表示之環烷基環，且R4表示氫原子、鹵 素原子、Cw烧基或ci-6鹵代烷基時，R5表示c3_6環烷 基（Cm)烧基、C1-4烷氧基^^“烷基〜^^鹵代烷氧基 (U烧基、cv4烷硫基（Ci 4)烷基、Ci 4鹵代烷硫基（Ci 4) 烧基、Cw烧亞磺醯基烷基、鹵代烷亞磺醯基 (c] _4)烧基、c〗_4烷磺醯基（Ci 4)烷基、c14鹵代烷磺醯 基（C^)烧基、c3_8環烷基、c3_8鹵代環烷基、-C(R9) = NOR11、_Si(R4(Rl4)Rl2、可被（z2)pi 取代之苯基、^萘· 基、2-奈基、L、M-4、m_5、m-8、M-9、M-14 至 M-18 或 Μ-1 9 ; (c)G為以G_71表示之環烷基環，且R4表示c3 6環烷基 (U燒基、Ci 4烷氧基（u烷基、4鹵代烷氧基（u 烧基、c!·4烧硫基（u烷基、Ci 4鹵代烷硫基（Ci 4)烷 基、c3_8環烷基、c3 8鹵代環烷基、。_6烷氧基、ci 6 鹵代烷氧基、Cw烷硫基、Ci 6鹵代烷硫基、Ci 6烷磺 基、Ci-6 鹵代烷磺醯基、M_4、M-5、M-8、M-9、M- 710 314918 14至M-l 8或Μ-19時，R5表示氫原子、鹵素原子、氮 基、C】_6烧基、C卜6 鹵代烧基、cs_6環垸基（Ci 4)烷基、 ci-4烷氧基（c1-4)烷基、cv4鹵代烷氧基（c^)烷基、c 1 - 4烧硫基（c〗_4)烷基、c〗_4鹵代烷硫基（U烷基、cl 4燒 亞磺醯基（C】·4)烷基、c^4鹵代烷亞磺醯基（(^_4)燒基、 C!·4烧石黃g蠢基（C〗 4)烧基、C!_4鹵代烧石黃酸基（C1-4)垸基、 C3·8%垸基、cs_8鹵代ί哀烧基、C〗-6烧氧基、C1-6鹵代烧 氧基、Cw垸硫基、Ci_6 代烧硫基、c1-6烧亞續醯基、 Cu i代烷亞磺醯基、Cl_6烷磺醯基、Cle6 _代烷磺醯 基、-C(R9)，ORn、-Si(Rl3)(Rl4)Rl2、M-4、μ·5、M-8、 Μ-9、Μ-14 至 Μ-18 或 Μ-19 ; ⑷G為以式G-71表示之環烷基環，且R4表示可被^2、 取代之苯基、1-萘基、h萘基、L-1至1^4、乙_15至1^ 17、L-19、L-2 0、L-22、L-23、L-45 至 L-47 或 L-50 時， R5表示氫原子、ώ素原子、氰基、Gw烷基或Gw鹵代 烷基； R 、R b、R6e及R6d表示氫原子； R6 e表示C,校就 基、ci 6烷磺醯基、Cl.6烷氧羰基、 二m)㈣基或可被（z2)m取代之苯基； R表不氫原子、鹵素原子或cN6烷基； R6j及R6k夂白婼a σ ’表示氫原子、鹵素原子、氰基 或甲基； R表示cK6烷基、^ 可被（Z ) p】取代之笨臬· 鹵代烧基、c3.8環烧基、或 711 314918 R11表示C!_6烧基或C1-6鹵代烧基，或者表示藉由 R9與R11 —起形成C2-3伸烷基鏈，並與鍵結之原子共同 形成之5員環或6員環’此時之伸烷基鏈可被C 1.6烷基 任意取代； R18 表示-OR28 …N(R29)R28、-S(0)rR3G、-C(R34) = NOH、-C(R34) =NOR33或可被（Z】)pl取代之苯基； R28表示氫原子、Cw烧基、C】·6烧魏基、ci-6烧氧 羰基、Cw烷胺羰基、C3-6環烷胺羰基、二（C16烷基） 胺羰基、可被（z1)^取代之苯胺羰基、可被（z】）pl取代之 笨基（Cb4)烷胺羰基、C&quot;烷磺醯基、二（Cl_6烷基）硫代 碟酿基或可被（z】）pl取代之苯基； R3G表示c】_6烷基、CV6烷硫基、可被（ζι)ρΐ取代之 苯基或L-45 ; R33表示Cw烷基； R34表示氫原子； m表示0至2之整數；以及 η表示0至2之整數。 如申請專利範圍第1至4項中任一項之Ν_苯曱酸苯胺 化合物或其鹽，其中： G為以式G-4、式G-5、式G-6、式G-7、式g 11、 式 G-13、式 G-14、式 G-15、式 G-17、式（Μ8、式 G-21、 式G-22或式G-23之任一者表示之非芳香族雜環· R表示C3.6環烧基（C1-4)烧基、CK4燒氧基（ChM完 基、Ci-4鹵代烷氧基(U烷基、CN4烷硫基（q 4)烧某、 314918 712 ci-4鹵代烷硫基（Cl_4)烷基、〇V4烷亞磺醯基（Cb4)烷基、 C1-4鹵代烷亞磺醯基（cv4)烷基、CV4烷磺醯基（c〗_4)烷 基、cv4鹵代燒石黃酿基（(：1·4)烧基、c3.8環烧基、c3_8鹵 代環烷基、吡咯烷-丨_基、噚唑烷-3_基、噻唑烷_3-基、 嗎咬-1·基、嗎福啉-丨_基、-C(R9)=N〇R&quot;、可被（Z2)pi 取代之苯基、；l-萘基、2-萘基、L、M-4、M-5、M-8、 、M-14 至 M-18 或 M-19。 如申請專利範圍第1至4項中任一項之取代N-苯（甲） 酸笨胺化合物或其鹽，其中： G 為以式 G-4、式 G-5、式 G-6、式 G-7、式 G-11、 式 G-13、式 G-14、式 G-15、式 G-17、式 G-18、式 G_21、 式G-22或式G-23之任一者表示之非芳香族雜環； R4表示cs·6環烷基（Cl_4)烷基、Ci_4烷氧基（u烷 基、Ci_4鹵代烷氧基（ci 4)烷基、4烷硫基(Cl 4)烷芙、 匕-4_代烷硫基（Cl.4)烷基、1_8環烷基、烷 基、可被（z2)pl取代之苯基、2_萘基、 s τ 土 、 L-15 至 L-17 、 L-19 、 L-20 、 L-22 、 L-23 、 L-45 至 L 47 50、Μ_4、Μ_5、Μ·8、m_9、M i4 至 -7、L- 或 Μ*·19。 如申請專利範圍第丨至3項中任一項之之取代 fe本胺化合物或其鹽，其中· 本（曱） 式 G-1〕、式 G-14、式 G—15、式 G17、式 二 G 1 式G-22或式G_23之任一者表示之非芳香埃雜广 V表示C丨.8烷基、c&quot;鹵代烷基、氰基衣， 、]、8)烷 j 314918 713 200407073 C3·6環烷基（C!·8)烧基、三（c】-4烷基）矽烷基（C18)烷基、 可被（Zi)pl取代之苯基（Cl_8)烷基、（L·；!)· (Ci8)烷基、 (1-2)-((^8)烷基、（L-3)-(C1-8)烷基、（ι^4)-((ν8)烷基、 (L-45)-(Cb8)烷基、(1^46)-((^8)烷基、（1^-47)-((^.8)烷 基、〇3_8環烷基、C3_8烯基、可被（ζι)ρ]取代之苯基（Cw) 烯基、C3·8炔基、可被（Ζι)ρΐ取代之苯基π〗。炔基、萘 一1-基-(Cw)炔基、萘_2_基（Cw)炔基、（L_1MC3 6)炔基、 (L 2) (C3-6)炔基、（L-3)-(C3_6)炔基、（L-4)-(C3.6)炔基、_ (L-45)-(C3-6)炔基、（L_46)_(C3 6)炔基或（L_47xC3_6)炔 基，或者表不藉由R2與R3 一起形成C26伸烷基鏈並與 鍵、、Ό之氮原子共同形成之3至7員環。 8·如申請專利範圍第4項之取代仏苯（甲）醯苯胺化合物或 其鹽，其中： G為以式G-4、式G-5、式G_6、式G_7、式G-U、 式 G-13、式匕14、式心15、式 G_i7、式 g_i8、式 G_n、 式G-22或式G_23之任一者表示之非芳香族雜環；以及 _ π表示c〗_8烷基、可被（zl)p]取代之笨基（Cu)烷 基、C3-8稀基或〇3.8快基。 9.如申請專利範圍第丄至3項之任一項之取代仏笨（甲） 酸苯胺化合物或其鹽，其中： G為以式G-4、式G-5、式G-6、式G_7、式G_u、 式 G-13、式 G-14、式 G-15、式 G-17、式 G-18、式 G_21、 式G-22或式g_23之任一者表示之非芳香族雜環； V表示被R]8任意取代之（C&quot;)烷基、c】_6烷胺羰基 314918 714 200407073 (&lt;!：3_6)稀基、^[-4、]\4-5、]\4-8、]\4-9、]^-13至]\4-19、]^21 或M-22 ’或者表示藉由以與以3 一起形成包含1個氧 原子或硫原子之C^6伸烷基鏈，並與鍵結之氮原子共同 形成之3至7貝環； R4表示氫原子、Cw烷基或鹵代烷基； R5表不氫原子、鹵素原子、氰基、Ci6烷基、C卜6 鹵代烧基、Cu烷氧基、Ci 6鹵代烷氧基、Cl-6烷硫基、 Cu鹵代烷硫基、C1-6烷亞磺醯基、（^_6鹵代烷亞磺醯 基、〇V6烧石買醯基、c1-6鹵代烧石黃酿基或二（(^_6)烧胺 基； R18 表示-OR28、_N(R29)R28、-S(O)rR30、Cl_6 烷氧羰 基、CV6 烧胺魏基、_c(0)N(R32)R31、-C(R34)=NOH、- C(R34)，〇R33 或 M ; R28表示氫原子、烷基、c1-6鹵代烷基、Cw烷 氧基（C!·4)烷基、C〗.4烷硫基（Cw)烷基、可被（z1)〆取代 之苯基（C〗_4)烷基、C〗·6烷羰基、c3_6環烷羰基、C^6烷 氧魏基、-C(0)N(R32)R31、c】_6烷磺醯基、二（Cw烷基） 胺續驗基、可被^。…取代之苯磺醯基、二（c&quot;烷基） 石粦酿基、二（C16烷基）硫代磷醯基、三（Ci_4烷基）矽烷基 或可被（z1)^取代之苯基； R29表示氫原子或烷基； R3G表示CV6烷基、cK6鹵代烷基、羥基（Cl_4)烷基、 Cl·4垸氧基（c】_4)烷基、C】_4烷硫基（Cw)烷基、¢:,.4烷羰 基（C】-4)烷基、（：】_4烷氧羰基（CN4)烷基、二（Cw烷基） 715 314918 200407073 胺羰基（c^)烷基、三（Cl_4烷基）矽烷基（Ci 4)烷基、可 被（Z〗）pl取代之笨基（C14)烧基、c3.6蝉基、c3_6炔基、 c〗_6烷硫基、可被di取代之苯基、L-21或L-45 ; R31表不Cu烷基、C】_4烷硫基（Ci 〇烷基、可被 取代之苯基（&lt;^_4)烧基、C3_0環烷基、C36烯基或可被 (Z%!取代之苯基； R32表示氫原子或Cl_6烷基，或者可藉由RS1與R32 一起形成CM伸烷基鏈，並與結合之氮原子共同形成3 至6員環，此時之伸烷基鏈可含有1個氧原子或硫原 子； R33表不Cu烧基或可被（ζι)ρΐ取代之苯基烷 基； R34表示氫原子或（^_6烷基； q2表示0至3之整數；… q3表示0至2之整數；以及 q4表示0至2之整數。 10·如申請專利範圍第4項之取代苯（甲）醯笨胺化合物或 其鹽’其中· G 為以式 G-4、式 G-5、式 G-6、式 G-7、式 G-11、 式 G-13、式 G-14、式 G-15、式 G-17、式 G-18、式 G-21、 式G-22或式G-23之任一者表示之非芳香族雜環； 表示被-OR28、-N(R29)r28、-S(〇) r3〇、c(r34)二 NOH或-C(R34)=N〇R33任意取代之Ci 8烷基； R4表示氯原子、C1-6烷基或C]_6鹵代烷基； 716 314918 200407073 R5表示氫原子、鹵素原子、氰基、Cb6烧基、 鹵代烷基、6-6烷氧基、Cw鹵代烷氧基、（^_6烷硫基、 鹵代烷硫基、Cw烷亞磺醯基、鹵代烷亞磺醯 基、Cw烷磺醯基、Cw鹵代烷磺醯基或二（C^)烷胺 基； R28表示氫原子、Cw烧基、Cu烧幾基、c&quot;烧氧 罗炭基、C1-6烧胺緩基、Cw環烧胺魏基、二（cl 6烧基） 胺羰基、可被（Z1)^取代之苯胺羰基、可被（ζι)ρΐ取代之 苯基（Ch4)烷胺羰基、Cw烷磺醯基、二（ci6烷基）硫代 磷醯基或可被（ζ!)ρ1取代之苯基； R。表示Cu烧基、C〗·6烧硫基、可被（ζ!)ρΐ取代之 苯基或L-45 ; R33表示C】_6烷基；以及 R34表示氫原子。 11 ·如申請專利範圍第！至5項及第7至8項之任一項之取 代N-笨（甲）酿苯胺化合物或其鹽，其中： G為以式G_7、式G_13、式匕14、式g_i5、式g_i7 或式G-18之任一者表示之非芳香族雜環； 表示鹵素原子、石肖基、c 校其 ^ ^ Γ Μ甘 月巷L&quot;说基、C“4鹵代烷基、 ΒΓ I Cl·4燒亞續酸基或C〗·4院項酸基，m表示2 守，口個X可彼此相同或彼此相異； 可彼此相同或 R4表示c C】·4丈兀基，n表示2時，各個Y c】·6鹵代烧基；以及 Ί\Ί 314918 200407073 R5表示可被（z2)pl取代之笨基、κ萘基、2_萘基、 L-1 至 L-5 、 L-8 至 L-24 、 L-28 至 L_36 、 L39 、 L41 、 L-42 、 L-45 至 L-47 或 L-50 。 12.如申請專利範圍第1至4項及第6至8項之任一項之取 代N-苯（甲）酸苯胺化合物或其鹽，其中· G 為以式 G_7、式 G_13、式 G_l4、式 gi5、式 g_i7 或G-1 8之任一者表示之非芳香族雜環· X表示鹵素原子、硝基、cw烷基、Ci4鹵代烷基、 c]_4烷硫基、Cl·4烷亞磺醯基或Ci4烷磺醯基，m表示2 時，各個X可彼此相同或相異； 丫表示處素原子或Cw烷基，η表示2時，各個Y 可彼此相同或相異； R4表示可被（Ζ2)ρ1取代之苯基、h萘基、L」至L- 4 、 L-15 至 L-17 、 L_19 、 L-20 、 L-22 、 L-23 、 L-45 、 L- 46或L-47 ;以及 R表示鹵素原子、CV6烷基、Cl 6鹵代烷基、Ci 6 烧氧基、鹵代烷氧基、Ci 6烷硫基、烷亞磺醯 基、ci·6烷磺醯基或二（C1-6)烷胺基。 1 3 ·如申請專利範圍第4項之取代N-苯（甲）醯笨胺化合物或 其鹽，其中： G為以式G-71表示之環烷基環； X表示鹵素原子、硝基、（:14烷基、鹵代烷基、 ci·6燒硫基、Cw烷亞磺醯基或c] 6烷磺醯基，m表示2 時，各個X可彼此相同或相異； 718 314918 200407073 Y表示鹵素原子或Ci·6烷基，n表示2時，各個γ 可彼此相同或相異； R3 表示被-OR28、_N(r29)r28、_S(〇)R3。…c(r34) = N0H以（R34㈣QR33任意取代之C&quot;烧基； R表不氫原子、鹵素原子、烷基或c鹵代烷 基； 取代之苯基、1-萘基、2-萘基、 R5表示可被（z2)pl L-1 至 L-4、L-15 至 L-17 L-45 、 L-46 或 L-47 ; L-19 、 L-20 、 L-22 、 L-23 ^ R表不氫原子、Cw烷基、Ci 6烷羰基、Gw烷氧 羰基、Cl·6烷胺羰基、Gw環烷胺羰基、二（(：1 6烷基） 胺幾基、可被（zl)pi取代之笨胺叛基、可被（Ζι)ρ1取代之 苯基（Cw)燒胺幾基、Ci.e燒續醯基、二（Ci6烧基）硫代 磷醯基或可被（ζ1)ρί取代之笨基； ^ R°G表示Cl-6烷基、Cw烷硫基、可被（ζ、】取代之 苯基或L-45 ; R33表示烷基；以及 R34表示氫原子。 14 士申明專利範圍第4項之取代N—苯（甲）醯苯胺化合物或 其鹽，其中： '马以式G·71表示之環燒基環； R表不可被（z2)pl取代之笨基、2_萘基、| 至 L-17 、 L-19 、 L-20 、 L-22 、 L-23 、 L-45 、 46或L-47 ;以及 719 3 ] 49^ 200407073 R表示氫原子、鹵素原子或C!.6烷基。 15.如申請專利範圍第14項之取代1苯（曱）醯笨胺化合物 或其鹽，其中： X表示鹵素原子、硝基、Cl.4烷基、Cw鹵代烷基、 Cw烧硫基、CV6烷亞磺醯基或Cu烷磺醯基，m表示2 時，各個X可彼此相同或相異； Y表示鹵素原子或CU6烷基，η表示2時，各個Y 可彼此相同或相異； 鲁 R5表示氫原子； R6i表示氫原子； R6J及R6k各自獨立，表示氫原子、鹵素原子或氰 基。 16·—種通式（2)或通式（3、# ; ^ r Μ )表不之1取代苯基硝基酞 亞胺或取代苯胺基或彼等之鹽：
    G表示式、式g 式 G-14、式 G_l5、^ 、式 G-7、式 G-U、式 G-13、 表示之非芳香族雜環，°^7、式G-18或式23之任一者 ^ 或者式G-7 1表示之環烷基環： 314918 720 200407073
    R5 R5 R5 R5
    G-71 ^ri K G-13 G-14 R5 /
    G-18 G23 y1代表鹵素原子、cv6烷基、CV6鹵代烷基、羥基 (CV6)烷基、cv3烷氧基（cv3)烷基、cv6烷氧基、cv6 鹵代烷氧基、（^_6烷硫基或Cw鹵代烷硫基； Y2代表鹵素原子、烷基、（^_6烷氧基或cv6烷 硫基，nl表示2時，各個Y2可彼此相同或相異； R4， (a)G 為以式 G-4、式 G-5、式 G-7、式 G-11、式 G-13、 式G-15、式G-17、式G-18或G-23之任一者表示之非 芳香族雜環時，R4表示Cy烷基、CV6鹵代烷基、C3.6 環烷基（CV4)烷基、CV4烷氧基（CV4)烷基、CV4鹵代烷 氧基（cv4)烷基、CV4烷硫基（CV4)烷基、c,_4鹵代烷硫 基（cv4)烷基、Cy烷亞磺醯基（CV4)烷基、CV4鹵代烷 721 314918 200407073 亞磺醯基（CV4)烷基、Ci_4烷磺醯基（Ci 4)烷基、Gy鹵 代烷磺醯基（Cw)烷基、Ci_4 _代烷氧基（Ci 4)函代烷 基、（：3-8環烷基、C3 8鹵代環烷基、Q、卜萘基、2_萘基、 L-1 至 L-4、L-8 至 L-13、L-15 至 L-23、L-3 0 至 L-3 5、 L-45 至 L-53、M-4、M-5、M-8、M-9、M-14 至 M-18 或 M-19 ; (b) G為以式G-14表示之非芳香族雜環時，R4表示Ci 6 鹵代烷基、Cw環烷基（υ烷基、Ci4烷氧基（Ci4)烷 _ 基、Cw鹵代烷氧基（Ci_4)烷基、Ci]烷硫基（CM)烷基、 C!-4鹵代烷硫基（Cw)烷基、Ci_4烷亞磺醯基（c】_4)烷基、 C】_4鹵代烷亞磺醯基（c〗_4)烷基、c】_4烷磺醯基（Ci-4)烷 基、C!·4鹵代烷磺醯基（Ci_4)烷基、Ci 4鹵代烷氧基（Ci· 4)i代烧基、Cs_8環烧基、cs_8鹵代環烧基、Q、le萘基、 2-萘基、L-1 至 L-4、L-8 至 L-13、L-15 至 L-23、L-30 至 L-35、L-45 至 L-53、M-4、M-5、Μ·8、M-9、M-14 至 M-18 或 M-19 ; (c) G為以式G-71表示之環烷基環時，R4表示鹵素原 子、c]_6烷基、c】_6鹵代烷基、Cw環烷基（Ci 4)烷基、 烧氧基（C】-4)烷基、cv4鹵代烷氧基（u烷基、 4烷硫基（c】_4)烷基、Cl·4鹵代烷硫基（c]-4)烷基、Ci 4烷 亞石尹、&amp;基（U；)：完基、c^4鹵代烧亞石黃酸基（cl 4)烧基、 c]_4烧磺酿基（υ烷基、c】_4鹵代烷磺醯基（c] 4)烷基、 C]-4鹵代烧氧基（Cl_4)鹵代烷基、Cm環烷基、鹵代 環院基、Cw烷氧基、c]_6鹵代烷氧基、c】_6烷硫基、 722 31491S 200407073 1-6幽代垸硫基、c1-6烷亞磺醯基、C^6 _代烷亞磺醯 基 Cl-6烷磺醯基、CV6鹵代烷磺醯基、Q、1-萘基、2-萘基、I 1 S T 至 L-4、L_8 至 L-13、L-15 至 L-23、L-30 至 L - 3 5 &gt; T a ^ -45 至 L-53、M-4、M-5、Μ·8、M-9、M-14 至 M-1 8 或]Μ-19 ; R5， ()為以式 G·*4、式 G-5、式 G-7、式 G-l 1、式 G-13、 工· 4、式G]5、式G]7、式G-l8或G_23之任一者攀 丁.. 、 非方香無雜環時，R5表示氫原子、鹵素原子、氰 基、Ci-6烷基、Cw鹵代烷基、C3_6環烷基（Cl 4)烷基、 ci-4烷氧基（U烷基、Ci 4鹵代烷氧基（Ci 4)烷基、Ci_ 4烧石Μ基（Cw)烷基、c1-4鹵代烷硫基（Cw)烷基、Ci-4烷 亞磺醯基（Ci·4)烷基、Ci 4鹵代烷亞磺醯基（Ci 4)烷基、 C!-4烧石黃酿基（Ci 4)烷基、Ci 4鹵代烷磺醯基（Ci 4)烷基、 C3·8環烧基、Cu鹵代環烷基、ci 6烷氧基、Cl 6鹵代烷 氧基、Cu烧硫基、c]_6鹵代烷硫基、ci6烷亞磺醯基、_ i代烧亞磺醯基、c16烷磺醯基、c] 6鹵代烷磺醯 基、二（Cl·6烷基）胺基、吡咯烷-1-基、噚唑烷基、噻 唑烷-3-基、哌啶小基、嗎福啉-卜基、-c(r9)=n〇r&quot;、 Q、1-萘基、2-萘基、l、M-4、M-5、M-8、M-9、M-14 至 M-18 或 VM9 ; (b)G為以式G-71表示之環烷基環，且R4表示鹵素原 子、c]·6烧基或c]_6鹵代烷基時，R5表示c3 6環烷基（Ci_j 烧基、C】·4燒氧基（c】_4)烷基、鹵代烷氧基（c^)烷 72 314918 200407073 基、ci-4垸硫基（cv4)烷基、Ci 4鹵代烷硫基（Ci 4)烷基、 CV4燒亞續醯基（Ci 4)烷基、Ci 4鹵代烷亞磺醯基（Ci 4) 烧基、c】·4烧磺酿基（Ci 4)烷基、Ci 4鹵代烷磺醯基（Ci_ 4)烧基、c3_8環烷基、c3 8鹵代環烷基…c(r9)=n〇R&quot;、 -Sl(Rl3)(Rl4)Rl2、Q、1-萘基、2-萘基、L-1 至 L-4、L-8 至 L-13、L-15 至 L-23、L-30 至 L-35、L-45 至 L-53、 M-4、M-5、M-8、M-9、M-14 至 M-18 或 M-19 ; (c)G為以式G_71表示之環烷基環，且r4表示Gy環烷鲁 基（C^)烷基、Cl·4烷氧基（Ci4)烷基、Ci4鹵代烷氧基 (cv4)烷基、Cl_4烷硫基（Ci 4)烷基、Ci 4鹵代烷硫基（I ^ 烷基、q·4烷亞磺醯基（Ci·4)烷基、q·4鹵代烷亞磺醯基 (Ci-4)烷基、C卜4烷磺醯基（c】·4)烷基、Ci_4鹵代烷磺醯 基（c】_4)烷基、Gw鹵代烷氧基（Ci·4)鹵代烷基、環 烷基、cs_8鹵代環烷基、Ci_6烷氧基、Ci 6鹵代烷氧基' cv6烷硫基、c16 _代烷硫基、Ci 6烷亞磺醯基、q 6 i代烷亞磺醯基、Cw烷磺醯基、Ci·6 _代烷磺醯基、鲁 M-4、M-5、M-8、M-9、M-14 至 M-18 或 M-19 時，R5 表示氫原子、鹵素原子、氰基、Cw烷基、代烷 基、c3.6^烷基（c]-4)烷基、cv4烷氧基（ci4)烷基、c] 4鹵代烷氧基（Cw)烷基、C】·4烷硫基J烷基、自 代烷硫基（c】.4)烷基、Cw烷亞磺醯基（u烷基、c 鹵代烷亞磺醯基（Cl·4)烷基、Cl·4烷磺醯基（Cm)烷基= CV4鹵代烷磺醯基（Cl_4)烷基、c3 8環烷基、匕^南^環 烷基、Cw烷氧基、c】_6鹵代烷氧基、c】_6烷硫基、c 3149】8 724 200407073 6鹵代烷硫基、Cm烷亞磺醯基、函代烷亞磺醯基、 CV6烷磺醯基、CV6鹵代烷磺醯基、-〇(以9)=^〇11]1、-Si(R13)(R14)R12、M-4、M-5、M-8、M-9、M-14 至 M-18 或 M-19 ; (d)G為以式G-71表示之環烷基環，且R4表示Q、1-萘基、2-萘基、L-1 至 L-4、L-8 至 L-13、L-15 至 L-23、 L-3 0至L-3 5、L-45至L-5 2或L-53時，R5表示氫原子、 鹵素原子、氰基、CV6烷基或CV6鹵代烷基； @ R6a、R6b、R6e及R6d表示氫原子； R6e表示cv6烷基、CV6烷磺醯基、CV6烷氧羰基、 二（Cb6烷基）磷醯基或Q ; R6i表示氫原子、鹵素原子或Cu烷基； R6j及R6k各自獨立，表示氫原子、鹵素原子、氰基 或曱基； Q為以下列Q-1至Q-11之任一者表示之可被取代 之笨基： _ 725 314918 200407073 Q-l
    ζΆ
    L為以下列式L-1至式L-58之任一者表示之芳香 族雜環：
    726 314918 200407073
    R15 N—N L-15 (ZV
    L-16 R15
    L-18
    (zV
    L-20
    L-21
    L-24 L-25
    727 314918 200407073 L-32 L-34
    (ζ%5 (ί L-31 (ZV (2%5 ：( S—( 八，] L-35 (ZV RlS R15 (ZV R；5 (Z\5
    L-40 广 JST N-N# N-N ιΆ ' · ，N'N^ 乂(As，N L-36 L-37 L-38 L-39 ,15 (ZX)p5 (Z^ R： ^=N N=^ N-N 乂N:k R15 N- N L41 L-42 L-43 L-44 X4 (0)t L-45
    L48 (Z%3 (Z\3
    L-49 (2^4 L50 r.N i3r(vC
    N^N人〇 L-54
    ^ ! rT 'N , ΓΓan^(Z)t4J^(z)p4J^ L-55 L-56 L-57 M-4、M-5、M-8、M-9、M-14 至 M-18 或 M-19 各 728 314918 表示下述之飽和雜環：
    M19 〜刊7073 、z】表不鹵素原子、氰基、硝基、c1-6烷基、CU6鹵 代烷基、Cw烷氧基、Cl_6鹵代烷氧基、Ci 6烷硫基、 Ck0 _代烷硫基、Cw烷亞磺醯基、Ci 6鹵代烷亞磺醯 基、Cw烷磺醯基、Cl_0 _代烷磺醯基、〇：16烷胺基或 s(C】_6烧基）胺基，pi、p2、p3或p4表示2以上之整 數時，各個Z1可彼此相同或相異； Z2a、z2b及z2d各自獨立，表示鹵素原子、氰基、 硝基、胺基、C!_6烧基、Cw鹵代烧基、（^_3燒氧基（c&quot; 烧基、C〗-3鹵代烷氧基（c]·3)烷基、C】_3烷硫基（Ci 3)垸 基、C】_3鹵代烷硫基（c]&quot;3)烷基、c]_3烷亞磺醯基（Ci，） 烧基、C】·3鹵代烷亞磺醯基烷基、C】·3烷磺醯基（c】 烷基、C]_3鹵代烷磺醯基（Ci·3)烷基、氰基烷基、 314918 729 200407073 C3_8環烷基、Cw鹵代環烷基、CV6烷氧基、CV6鹵代燒 氧基、&lt;^_6烷磺醯氧基、c 鹵代烷磺醯氧基、可被 取代之苯氧基、5_三氟曱基吡啶-2-基氧、3·氣-5-三氟 甲基吡啶-2-基氧、Cl 6烷硫基、CV6 _代烷硫基、C, ^ ~ 8 環烷硫基、Cw烷亞磺醯基、鹵代烷亞磺醯基、C 3-8 環烧亞磺醯基、C16烷磺醯基、C16鹵代烷磺醯基、C 3'8 環烷磺醯基、Cl 0烷胺基、二（Ci_6烷基）胺基、Ci·6烷胺 磺酸基、二（Cw烷基）胺磺醯基、_C(0)NH2、CV6烷胺 魏基、二（Ci-6烷基）胺羰基、-C(S)NH2或三（Cu烷基） 矽烷基； 再者，可藉由z2a與z2b或者Z2a與Z2d形成-0CF2CK， 並各與鍵結之碳原子共同形成5員環； z2c表示i素原子、Cl_6烷基或C16鹵代烷基； R表不Cu烷基、Ci_6扇代烷基、C3·8環烷基或可 被（zl)pl取代之笨基； 表、Cu烧基或ci6鹵代烧基，或者可藉由r9 /、 起^成C：2_3伸烧基鏈，並與鍵結之原子共同形 成5貝環或6員環，此時之伸烷基鏈可被C16烷基任意 取代； R表不Ci·6烷基或可被（Z】）pl取代之苯基； R1·3及R14各自獨立表示Cu烧基； R表不C]·6烷基或可被（ζι、】取代之笨基； R2:&gt;表示cK4烷基； nl表示〇至3之整數； 314918 730 200407073 p 1表示1至5之整數； p2表示0至4之整數； p3表示0至3之整數； p4表示0至2之整數； p5表示0或1之整數； q3表示0至2之整數； q4表示0至2之整數； r表示0至2之整數；以及 t表示0或1之整數。 1 7. —種有害生物防止與去除劑，其特徵為含有從申請專利 範圍第1至1 5項中任一項之N-苯曱醯苯胺化合物及其 鹽中選出之1種或2種以上化合物為有效成分者。 1 8. —種農藥，其特徵為含有從申請專利範圍第1至1 5項 中任一項之N-苯甲醯苯胺化合物及其鹽中選出之1種 或2種以上化合物為有效成分者。 1 9. 一種殺蟲劑或滅虱劑，其特徵為含有從申請專利範圍第 1至1 5項中任一項之N-苯曱醯苯胺化合物及其鹽中選 出之1種或2種以上化合物為有效成分者。 73] 314918 200407073 柒、 指定代表圖： (一） 本案指定代表圖為：第（ ）圖。 (二) 本代表圖之元件代表符號簡單說明： 本案無圖式。 捌、 本案若有化學式時，請揭示最能顯示發明特徵的化學式：
    ji 6 314918
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