TR201904204T4 - Eklemsiz aljinat kapsülleri. - Google Patents
Eklemsiz aljinat kapsülleri. Download PDFInfo
- Publication number
- TR201904204T4 TR201904204T4 TR2019/04204T TR201904204T TR201904204T4 TR 201904204 T4 TR201904204 T4 TR 201904204T4 TR 2019/04204 T TR2019/04204 T TR 2019/04204T TR 201904204 T TR201904204 T TR 201904204T TR 201904204 T4 TR201904204 T4 TR 201904204T4
- Authority
- TR
- Turkey
- Prior art keywords
- jointless
- dried
- alginate
- shell membrane
- content
- Prior art date
Links
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 title abstract 6
- 229940072056 alginate Drugs 0.000 title abstract 6
- 235000010443 alginic acid Nutrition 0.000 title abstract 6
- 229920000615 alginic acid Polymers 0.000 title abstract 6
- 239000002775 capsule Substances 0.000 title abstract 5
- 210000000998 shell membrane Anatomy 0.000 abstract 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 229910021645 metal ion Inorganic materials 0.000 abstract 2
- 239000000872 buffer Substances 0.000 abstract 1
- 238000010494 dissociation reaction Methods 0.000 abstract 1
- 230000005593 dissociations Effects 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
- B01J13/046—Making microcapsules or microballoons by physical processes, e.g. drying, spraying combined with gelification or coagulation
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/20—After-treatment of capsule walls, e.g. hardening
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/20—After-treatment of capsule walls, e.g. hardening
- B01J13/206—Hardening; drying
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- General Preparation And Processing Of Foods (AREA)
- Formation And Processing Of Food Products (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Mevcut buluş, dolgu materyalini kapsülleyen tüm aljinat kabuk membranını içeren bir kurutulmuş eklemsiz kapsüle yöneliktir, burada: (i) bahsedilen aljinat kabuk membranı şunlara sahip bir polivalent metal iyon aljinatı içerir: (a) M ve G içeriğinin ağırlığına göre ağırlıkça %50-%62 ortalama M içeriği, ve (b) 60 rpm'de bir Brookfield LV viskometre ve mil no 1 kullanılarak 20 C'de %3,5'lik bir su çözeltisinde bir monovalent metal iyonu aljinatı olarak ölçüldüğünde 35 ila 80 cps'lik bir viskozite; (ii) bahsedilen aljinat kabuk membranı bahsedilen dolgu materyalinin ağırlığına göre en az %50 miktarında bir yağ içeriğini kapsüller; (iii) bahsedilen kurutulmuş eklemsiz kapsül, 0,1 M NaCl ve HCI, pH 3 bir çözeltinin 37 C'de 20 dakikalık bir ön işleminden sonra tüm intestinal tamponlarda 12 dakikadan kısa ayrışma süresine sahiptir; ve (iv) bahsedilen kurutulmuş eklemsiz kapsül en az 7kg'lık bir kuru kırılma kuvveti mukavemetine sahiptir. Mevcut buluş ayrıca böyle kurutulmuş eklemsiz kapsüllerin üretim ve kullanım yöntemlerine de yöneliktir.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24126609P | 2009-09-10 | 2009-09-10 | |
US24126309P | 2009-09-10 | 2009-09-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201904204T4 true TR201904204T4 (tr) | 2019-04-22 |
Family
ID=43647961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/04204T TR201904204T4 (tr) | 2009-09-10 | 2010-09-02 | Eklemsiz aljinat kapsülleri. |
Country Status (10)
Country | Link |
---|---|
US (2) | US8980312B2 (tr) |
EP (2) | EP2475395B1 (tr) |
JP (2) | JP5696149B2 (tr) |
KR (2) | KR101760534B1 (tr) |
CN (2) | CN102625715B (tr) |
BR (2) | BR112012005453B1 (tr) |
ES (1) | ES2716984T3 (tr) |
IL (2) | IL218562A0 (tr) |
TR (1) | TR201904204T4 (tr) |
WO (2) | WO2011031621A2 (tr) |
Families Citing this family (24)
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CA2882048C (en) | 2006-02-03 | 2020-03-24 | Proventiv Therapeutics, Llc | Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3 |
PL2679228T3 (pl) | 2006-06-21 | 2018-07-31 | Opko Ireland Global Holdings, Ltd. | Terapia z użyciem środka do uzupełniania witaminy D i środka do zastępowania hormonami witaminy D |
WO2008134523A1 (en) | 2007-04-25 | 2008-11-06 | Proventiv Therapeutics, Llc | Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease |
EP3542792B1 (en) | 2007-04-25 | 2023-06-28 | EirGen Pharma Ltd. | Controlled release 25-hydroxyvitamin d |
ES2403107T3 (es) | 2007-04-25 | 2013-05-14 | Cytochroma Inc. | Método de tratamiento de insuficiencia y deficiencia de vitamina D |
EP2065046B1 (en) * | 2007-11-30 | 2013-07-31 | Kao Corporation | Gip secretion inhibitor |
US8962239B2 (en) | 2008-04-02 | 2015-02-24 | Opko Renal, Llc | Methods useful for vitamin D deficiency and related disorders |
US8338389B2 (en) | 2009-06-17 | 2012-12-25 | Kao Corporation | Agent for preventing or ameliorating obesity |
HUE048464T2 (hu) | 2010-03-29 | 2020-07-28 | Opko Ireland Global Holdings Ltd | Módszerek és készítmények mellékpajzsmirigy szintjének csökkentésére |
US9661844B2 (en) * | 2012-04-30 | 2017-05-30 | Dow Agrosciences Llc | Pesticide composition delivery vehicles |
CN103146036B (zh) * | 2013-03-02 | 2015-05-27 | 福建农林大学 | 一种食品包装用高强度高抗菌性海藻酸钠膜及其制备方法 |
KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 d 방출 제형 |
JP6472747B2 (ja) * | 2013-05-26 | 2019-02-20 | 三粧化研株式会社 | 魚卵状カプセル体、その製造法およびその製造装置 |
US20160228377A1 (en) * | 2013-09-19 | 2016-08-11 | Beta-Cell Nv | Method for the treatment of diabetes mellitus |
FR3013233B1 (fr) * | 2013-11-19 | 2016-01-01 | Capsum | Procede de preparation de capsules comprenant un coeur liquide et une coque externe |
CN103736201B (zh) * | 2013-12-31 | 2016-01-20 | 原子高科股份有限公司 | 一种放射性粒子链 |
CA2957240A1 (en) | 2014-08-07 | 2016-02-11 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin d |
BR112017013598A2 (pt) * | 2014-12-23 | 2018-03-06 | Fmc Corp | composições de revestimento de película entérico, método de revestimento, e formas revestidas |
JP7032322B2 (ja) | 2016-03-28 | 2022-03-08 | オプコ アイルランド グローバル ホールディングス リミテッド | ビタミンd治療法 |
US20180021237A1 (en) * | 2016-07-20 | 2018-01-25 | Hans P.I. Claesson | Adhesive materials and sequestered curing agents used to produce them |
CN106675057B (zh) * | 2017-03-02 | 2019-04-02 | 重庆交通大学 | 硬壳海藻酸钙油囊的制备方法 |
US10865160B2 (en) * | 2017-09-12 | 2020-12-15 | Pratian, Llc | Nutrient-containing porous biodegradable bead |
CN111743848A (zh) * | 2020-06-28 | 2020-10-09 | 西安文理学院 | 一种含鹿茸的抗衰老面膜及其制备方法 |
KR102419202B1 (ko) | 2022-04-18 | 2022-07-08 | 나인건설 주식회사 | 시공성을 개선한 건축물의 보강장치 및 이의 시공 방법 |
Family Cites Families (32)
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GB1015251A (en) * | 1963-03-12 | 1965-12-31 | Glaxo Lab Ltd | Aqueous pharmaceutical compositions in capsule form |
US4520142A (en) * | 1984-02-17 | 1985-05-28 | Minnesota Mining And Manufacturing Company | Aerosol application of encapsulated materials |
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JPH1176369A (ja) * | 1997-09-12 | 1999-03-23 | Sansho Iyaku Kk | 腸溶性軟カプセル |
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EP1426045B1 (de) | 2002-12-05 | 2006-09-27 | Symrise GmbH & Co. KG | Nahtlose gefüllte Kapseln |
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CL2004000794A1 (es) * | 2003-04-14 | 2005-05-06 | Fmc Corp | Pelicula de gel que comprende una cantidad formadora de kappa-2 carragenano, opcionalmente un plastificante, un segundo formador de pelicula, agente de relleno y un controlador de ph, procedimiento para prepararla, capsulas blandas que la incluyen, s |
EP1732680B1 (en) * | 2004-02-17 | 2008-07-30 | Symrise GmbH & Co. KG | Coated sherical seamless filled capsules |
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WO2006136196A1 (en) | 2005-06-21 | 2006-12-28 | V. Mane Fils | Gellan seamless breakable capsule and process for manufacturing thereof |
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US20100062057A1 (en) * | 2008-09-10 | 2010-03-11 | Pronova BioPharma Norge AS. | Formulation |
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2010
- 2010-09-02 KR KR1020127009102A patent/KR101760534B1/ko active IP Right Grant
- 2010-09-02 WO PCT/US2010/047662 patent/WO2011031621A2/en active Application Filing
- 2010-09-02 JP JP2012528838A patent/JP5696149B2/ja active Active
- 2010-09-02 EP EP10815933.6A patent/EP2475395B1/en active Active
- 2010-09-02 ES ES10815930T patent/ES2716984T3/es active Active
- 2010-09-02 WO PCT/US2010/047652 patent/WO2011031617A2/en active Application Filing
- 2010-09-02 CN CN201080040689.0A patent/CN102625715B/zh active Active
- 2010-09-02 US US12/874,567 patent/US8980312B2/en active Active
- 2010-09-02 CN CN201080040690.3A patent/CN102596251B/zh active Active
- 2010-09-02 US US12/874,618 patent/US9895672B2/en active Active
- 2010-09-02 EP EP10815930.2A patent/EP2475394B1/en active Active
- 2010-09-02 BR BR112012005453-8A patent/BR112012005453B1/pt not_active IP Right Cessation
- 2010-09-02 TR TR2019/04204T patent/TR201904204T4/tr unknown
- 2010-09-02 BR BR112012005452-0A patent/BR112012005452B1/pt active IP Right Grant
- 2010-09-02 KR KR1020127009103A patent/KR101900505B1/ko active IP Right Grant
- 2010-09-02 JP JP2012528841A patent/JP5696150B2/ja active Active
-
2012
- 2012-03-08 IL IL218562A patent/IL218562A0/en active IP Right Grant
- 2012-03-08 IL IL218564A patent/IL218564A/en active IP Right Grant
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