TR201900694T4 - 158p1d7 proteinlerine bağlanan antikor ilaç konjugatları (adc). - Google Patents

158p1d7 proteinlerine bağlanan antikor ilaç konjugatları (adc). Download PDF

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Publication number
TR201900694T4
TR201900694T4 TR2019/00694T TR201900694T TR201900694T4 TR 201900694 T4 TR201900694 T4 TR 201900694T4 TR 2019/00694 T TR2019/00694 T TR 2019/00694T TR 201900694 T TR201900694 T TR 201900694T TR 201900694 T4 TR201900694 T4 TR 201900694T4
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TR
Turkey
Prior art keywords
bind
drug conjugates
antibody drug
adc
proteins
Prior art date
Application number
TR2019/00694T
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English (en)
Turkish (tr)
Inventor
Kendall Morrison Robert
An Zili
Jane Meyrick Morrison Karen
Snyder Josh
Jia Xiao-Chi
Original Assignee
Agensys Inc
Seattle Genetics Inc
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Application filed by Agensys Inc, Seattle Genetics Inc filed Critical Agensys Inc
Publication of TR201900694T4 publication Critical patent/TR201900694T4/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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