MX2019004514A - Conjugados de anticuerpo farmaco (adc) que enlazan a las proteinas 158p1d7. - Google Patents

Conjugados de anticuerpo farmaco (adc) que enlazan a las proteinas 158p1d7.

Info

Publication number
MX2019004514A
MX2019004514A MX2019004514A MX2019004514A MX2019004514A MX 2019004514 A MX2019004514 A MX 2019004514A MX 2019004514 A MX2019004514 A MX 2019004514A MX 2019004514 A MX2019004514 A MX 2019004514A MX 2019004514 A MX2019004514 A MX 2019004514A
Authority
MX
Mexico
Prior art keywords
adc
bind
drug conjugates
antibody drug
proteins
Prior art date
Application number
MX2019004514A
Other languages
English (en)
Inventor
Kendall Morrison Robert
An Zili
Jane Meyrick Morrison Karen
Snyder Josh
Jia Xiao-Chi
Original Assignee
Agensys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agensys Inc filed Critical Agensys Inc
Publication of MX2019004514A publication Critical patent/MX2019004514A/es

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Abstract

Se describen en la presente conjugados de anticuerpo fármaco (ADC´s) que enlazan a la proteína 158P1D7 y variantes de la misma. La proteína 158P1D7 exhibe expresión específica de tejido en el tejido de adulto normal, y se expresa aberrantemente en los cánceres listados en la Tabla I. Consecuentemente, los ADC´s de la invención proporcionan una composición terapéutica para el tratamiento de cáncer.
MX2019004514A 2012-08-23 2015-02-20 Conjugados de anticuerpo farmaco (adc) que enlazan a las proteinas 158p1d7. MX2019004514A (es)

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